631787
constant: true
units: dimensionless
value: 0.15
name: K_z
type: Parameter

631793
constant: true
units: dimensionless
value: -4.0
name: beta_1
type: Parameter

631776
constant: false
units: 124113
value: 0.067593139865
name: TRPN
type: Parameter

631802
constant: false
units: 124064
value: NaN
name: beta_Tm
type: Parameter

124101
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

124247
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

631849
constant: true
units: 124064
value: 0.625
name: alpha_3
type: Parameter

631830
constant: false
units: dimensionless
value: NaN
name: Q
type: Parameter

631844
constant: true
units: dimensionless
value: 129.0
name: A_3
type: Parameter

124210
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

124138
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

631840
constant: true
units: dimensionless
value: -29.0
name: A_1
type: Parameter

631734
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

631820
constant: false
units: dimensionless
value: NaN
name: overlap
type: Parameter

631826
constant: false
units: 124150
value: NaN
name: T_Base
type: Parameter

631836
constant: false
units: dimensionless
value: 0.0
name: Q_2
type: Parameter

631822
constant: true
units: dimensionless
value: 4.9
name: beta_0
type: Parameter

124235
unit: 124271
unit: 124259
unit: 124247
name: mM_per_ms
type: SBMLUnitsDef

124150
unit: 124174
unit: 124162
name: N_per_mm2
type: SBMLUnitsDef

631805
constant: true
units: 124113
value: 0.07
name: Ca_TRPN_Max
type: Parameter

124113
unit: 124138
unit: 124126
name: mM
type: SBMLUnitsDef

631782
constant: true
units: 124064
value: 0.002
name: alpha_r1
type: Parameter

631796
constant: false
units: 124113
value: NaN
name: Ca_TRPN_50
type: Parameter

124076
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

631801
constant: false
units: 124064
value: NaN
name: alpha_Tm
type: Parameter

124283
unit: 124295
name: time
type: SBMLUnitsDef

631811
constant: true
units: dimensionless
value: 2.0
name: gamma_trpn
type: Parameter

631773
constant: false
units: 124113
value: NaN
name: Ca_i
type: Parameter

631846
constant: true
units: 124064
value: 0.03
name: alpha_1
type: Parameter

631815
constant: false
units: dimensionless
value: NaN
name: ExtensionRatio
type: Parameter

124174
exponent: -2.0
scale: -3
multipler: 1.0
kind: METRE
type: SBMLUnit

631790
constant: true
units: 124113
value: 0.00105
name: Ca_50ref
type: Parameter

124126
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

631795
constant: false
units: 124113
value: NaN
name: Ca_50
type: Parameter

124222
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

631785
constant: true
units: dimensionless
value: 3.0
name: n_Rel
type: Parameter

631799
constant: false
units: 124064
value: NaN
name: K_1
type: Parameter

631781
constant: true
units: 124064
value: 0.008
name: alpha_0
type: Parameter

124271
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

631778
constant: false
units: dimensionless
value: 0.014417937837
name: z
type: Parameter

631804
constant: false
units: 124235
value: NaN
name: J_TRPN
type: Parameter

631842
constant: true
units: dimensionless
value: 138.0
name: A_2
type: Parameter

124198
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

631819
constant: false
units: dimensionless
value: NaN
name: lambda_prev
type: Parameter

631832
constant: true
units: dimensionless
value: 0.35
name: a
type: Parameter

124259
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

631847
constant: true
units: 124064
value: 0.13
name: alpha_2
type: Parameter

631810
constant: true
units: 124064
value: 0.2
name: k_Ref_off
type: Parameter

631834
constant: false
units: dimensionless
value: 0.0
name: Q_1
type: Parameter

631784
constant: true
units: 124064
value: 0.00175
name: alpha_r2
type: Parameter

631828
constant: false
units: 124150
value: NaN
name: T_0
type: Parameter

631851
constant: false
units: 124150
value: NaN
name: Tension
type: Parameter

631791
constant: true
units: dimensionless
value: 0.85
name: z_p
type: Parameter

631817
constant: false
units: 124064
value: NaN
name: dExtensionRatiodt
type: Parameter

124064
unit: 124076
name: per_ms
type: SBMLUnitsDef

124162
exponent: 1.0
scale: 0
multipler: 1.0
kind: NEWTON
type: SBMLUnit

124186
unit: 124222
unit: 124210
unit: 124198
name: per_mM_per_ms
type: SBMLUnitsDef

124088
unit: 124101
name: ms
type: SBMLUnitsDef

631807
constant: false
units: 124064
value: NaN
name: k_off
type: Parameter

631798
constant: false
units: 124064
value: NaN
name: K_2
type: Parameter

631779
constant: false
units: dimensionless
value: NaN
name: z_max
type: Parameter

631838
constant: false
units: dimensionless
value: 0.0
name: Q_3
type: Parameter

631824
constant: true
units: 124150
value: 56.2
name: T_ref
type: Parameter

631808
constant: true
units: 124186
value: 100.0
name: k_on
type: Parameter

631813
constant: false
units: dimensionless
value: NaN
name: lambda
type: Parameter

631775
constant: false
units: 124113
value: NaN
name: Ca_b
type: Parameter

MODEL8687196544
compartment: 631734
units def: 124186
parameter: 631810
parameter: 631782
parameter: 631851
rule: 631772
rule: 631762
parameter: 631842
parameter: 631832
parameter: 631824
parameter: 631819
rule: 631745
parameter: 631813
parameter: 631785
parameter: 631788
parameter: 631844
parameter: 631847
parameter: 631826
rule: 631738
rule: 631754
rule: 631744
rule: 631736
rule: 631769
is described by: http://identifiers.org/pubmed/16339881
parameter: 631815
parameter: 631799
parameter: 631849
rule: 631741
units def: 124088
parameter: 631779
rule: 631759
units def: 124113
parameter: 631781
rule: 631765
parameter: 631840
parameter: 631830
parameter: 631822
parameter: 631808
rule: 631756
volume units: 679943
substance units: metaid_0000106
parameter: 631820
parameter: 631811
parameter: 631801
parameter: 631802
parameter: 631795
rule: 631760
rule: 631739
parameter: 631846
parameter: 631836
name: Niederer2006_CardiacMyocyteRelaxation
parameter: 631776
units def: 124150
parameter: 631804
parameter: 631817
parameter: 631807
parameter: 631798
parameter: 631838
rule: 631742
parameter: 631791
rule: 631750
parameter: 631778
curated: false
area units: area
rule: 631766
rule: 631757
rule: 631747
units def: 124283
notes: This a model from the article: A quantitative analysis of cardiac myocyte relaxation: a simulation study. Niederer SA, Hunter PJ, Smith NP. Biophys J. 2006:90(5):1697-722. 16339881 , Abstract: The determinants of relaxation in cardiac muscle are poorly understood, yet compromised relaxation accompanies various pathologies and impaired pump function. In this study, we develop a model of active contraction to elucidate the relative importance of the [Ca2+]i transient magnitude, the unbinding of Ca2+ from troponin C (TnC), and the length-dependence of tension and Ca2+ sensitivity on relaxation. Using the framework proposed by one of our researchers, we extensively reviewed experimental literature, to quantitatively characterize the binding of Ca2+ to TnC, the kinetics of tropomyosin, the availability of binding sites, and the kinetics of crossbridge binding after perturbations in sarcomere length. Model parameters were determined from multiple experimental results and modalities (skinned and intact preparations) and model results were validated against data from length step, caged Ca2+, isometric twitches, and the half-time to relaxation with increasing sarcomere length experiments. A factorial analysis found that the [Ca2+]i transient and the unbinding of Ca2+ from TnC were the primary determinants of relaxation, with a fivefold greater effect than that of length-dependent maximum tension and twice the effect of tension-dependent binding of Ca2+ to TnC and length-dependent Ca2+ sensitivity. The affects of the [Ca2+]i transient and the unbinding rate of Ca2+ from TnC were tightly coupled with the effect of increasing either factor, depending on the reference [Ca2+]i transient and unbinding rate. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Niederer, Hunter, Smith. (2006) - version02 The original CellML model was created by: Terkildsen, Jonna, j.terkildsen@auckland.ac.nz The University of Auckland Auckland …
type: SBMLModel
parameter: 631793
parameter: 631784
units def: 124064
rule: 631763
parameter: 631834
rule: 631771
rule: 631748
parameter: 631773
parameter: 631805
parameter: 631796

631788
constant: true
units: dimensionless
value: 3.0
name: n_Hill
type: Parameter

124295
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit