662405
constant: false
units: 100778
value: 0.0
name: CD_R
type: Parameter

662358
constant: false
units: 100814
value: 0.0
name: ATbl
type: Parameter

101019
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

662619
constant: true
units: dimensionless
value: 0.62
name: PDb
type: Parameter

662415
constant: true
units: 101031
value: 3.13
name: kDT_off
type: Parameter

662595
constant: true
units: 101031
value: 87.93
name: k1T
type: Parameter

662629
constant: true
units: 100778
value: 500000.0
name: CA
type: Parameter

662383
constant: false
units: 100814
value: 0.0
name: ADl
type: Parameter

662435
constant: false
units: 100778
value: 0.0
name: CDDcd
type: Parameter

100971
unit: 100983
name: kg
type: SBMLUnitsDef

662649
constant: true
units: 100778
value: 0.6275
name: CTb
type: Parameter

662575
constant: true
units: 101031
value: 0.014
name: kcd1
type: Parameter

100947
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

662611
constant: true
units: dimensionless
value: 1.0
name: PTst
type: Parameter

100887
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

662363
constant: false
units: 100778
value: 0.0
name: CT_A
type: Parameter

662589
constant: true
units: 100899
value: 0.061
name: Qt
type: Parameter

662639
constant: true
units: 100778
value: 307.29
name: CTif
type: Parameter

100814
unit: 100826
name: nanomole
type: SBMLUnitsDef

662425
constant: true
units: 101055
value: 0.14
name: kTT_on
type: Parameter

662231
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

662457
constant: true
units: 101031
value: 0.56
name: kDNA_offDT5a
type: Parameter

100826
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

101104
unit: 101116
name: time
type: SBMLUnitsDef

662581
constant: true
units: 101031
value: 0.043
name: kflo
type: Parameter

662557
constant: true
units: 100899
value: 71.9
name: keR
type: Parameter

662633
constant: true
units: 100778
value: 0.92
name: CDl
type: Parameter

100959
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

101031
unit: 101043
name: first_order_rate_constant
type: SBMLUnitsDef

662443
constant: true
units: 101055
value: 0.14
name: kDNA_onDDsec
type: Parameter

662463
constant: true
units: 101031
value: 0.8
name: kDNA_offDTcd
type: Parameter

662505
constant: true
units: dimensionless
value: 0.79
name: NTp
type: Parameter

662547
constant: true
units: dimensionless
value: 0.75
name: alpha_D
type: Parameter

662643
constant: true
units: 100778
value: 0.075
name: CDNAsec
type: Parameter

662497
constant: true
units: 101055
value: 0.14
name: kDNA_onTTcp
type: Parameter

662395
constant: false
units: 100814
value: 0.0
name: ATp
type: Parameter

662623
constant: true
units: 100778
value: 7.6
name: CTbl
type: Parameter

662567
constant: false
units: 100935
value: NaN
name: Vmax
type: Parameter

662607
constant: true
value: 2.89
name: Vmax0
type: Parameter

662477
constant: false
units: 100778
value: 0.0
name: CTT5a
type: Parameter

662515
constant: false
units: 100778
value: NaN
name: CDNAcdf
type: Parameter

662483
constant: false
units: 100778
value: 0.0
name: CTTcd
type: Parameter

662377
constant: false
units: 100778
value: NaN
name: CDblf
type: Parameter

662653
constant: true
units: 100971
value: 1.0E-4
name: VPC1b
type: Parameter

662537
constant: true
units: 100899
value: 0.13
name: kLH1
type: Parameter

100790
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

662617
constant: true
units: dimensionless
value: 1.0
name: PTb
type: Parameter

662403
constant: true
units: 101031
value: 0.069
name: kTR_off
type: Parameter

662423
constant: false
units: 100778
value: 0.0
name: CTT
type: Parameter

662371
constant: true
units: 101055
value: 0.15
name: kDA_on
type: Parameter

100983
exponent: 1.0
scale: 0
multipler: 1.0
kind: KILOGRAM
type: SBMLUnit

662597
constant: true
units: 101031
value: 77.2
name: k1D
type: Parameter

662381
constant: false
units: 100814
value: 0.0
name: ATl
type: Parameter

662501
constant: false
units: 100778
value: NaN
name: CTpf
type: Parameter

662417
constant: false
units: 100778
value: 0.0
name: CDD
type: Parameter

100850
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM
type: SBMLUnit

662521
constant: false
units: 100778
value: NaN
name: CDNAcpf
type: Parameter

662361
constant: false
units: 100814
value: 0.0
name: ADbl
type: Parameter

662577
constant: false
units: litre
value: 0.0
name: VPL1
type: Parameter

100899
unit: 100923
unit: 100911
name: l_hr
type: SBMLUnitsDef

100802
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

101055
unit: 101092
unit: 101080
unit: 101068
name: second_order_rate_constant
type: SBMLUnitsDef

662437
constant: true
units: 101055
value: 0.14
name: kDNA_onDDcd
type: Parameter

662661
constant: true
units: 100778
value: 52.46
name: CDp
type: Parameter

662587
constant: true
units: 100899
value: 1.06
name: Ql
type: Parameter

100935
unit: 100959
unit: 100947
name: nmol_hr
type: SBMLUnitsDef

662637
constant: true
units: 100814
value: 0.104
name: CLH
type: Parameter

MODEL8684444027
parameter: 662391
parameter: 662557
rule: 662260
parameter: 662593
rule: 662256
units def: 100778
parameter: 662531
rule: 662335
notes: This a model from the article: Mathematical model for the androgenic regulation of the prostate in intact and castrated adult male rats. Potter LK, Zager MG, Barton HA. Am J Physiol Endocrinol Metab. 2006:91(5):E952-64. 16757547 , Abstract: The testicular-hypothalamic-pituitary axis regulates male reproductive system functions. Understanding these regulatory mechanisms is important for assessing the reproductive effects of environmental and pharmaceutical androgenic and antiandrogenic compounds. A mathematical model for the dynamics of androgenic synthesis, transport, metabolism, and regulation of the adult rodent ventral prostate was developed on the basis of a model by Barton and Anderson (1997). The model describes the systemic and local kinetics of testosterone (T), 5alpha-dihydrotestosterone (DHT), and luteinizing hormone (LH), with metabolism of T to DHT by 5alpha-reductase in liver and prostate. Also included are feedback loops for the positive regulation of T synthesis by LH and negative regulation of LH by T and DHT. The model simulates maintenance of the prostate as a function of hormone concentrations and androgen receptor (AR)-mediated signal transduction. The regulatory processes involved in prostate size and function include cell proliferation, apoptosis, fluid production, and 5alpha-reductase activity. Each process is controlled through the occupancy of a representative gene by androgen-AR dimers. The model simulates prostate dynamics for intact, castrated, and intravenous T-injected rats. After calibration, the model accurately captures the castration-induced regression of the prostate compared with experimental data that show that the prostate regresses to approximately 17 and 5% of its intact weight at 14 and 30 days postcastration, respectively. The model also accurately predicts serum T and AR levels following castration compared with data. This model provides a framework for quantifying the kinetics and effects of environmental and pharmaceutica…
parameter: 662607
parameter: 662537
parameter: 662643
parameter: 662573
rule: 662307
parameter: 662649
parameter: 662579
rule: 662279
rule: 662321
rule: 662254
curated: false
parameter: 662507
rule: 662295
parameter: 662603
parameter: 662629
area units: area
parameter: 662645
rule: 662311
rule: 662240
parameter: 662591
parameter: 662503
parameter: 662529
parameter: 662625
rule: 662276
parameter: 662661
parameter: 662389
units def: 100971
rule: 662347
length unit: length
parameter: 662369
rule: 662262
parameter: 662385
rule: 662258
parameter: 662637
parameter: 662435
parameter: 662365
parameter: 662617
rule: 662244
parameter: 662477
rule: 662323
rule: 662337
parameter: 662431
parameter: 662457
rule: 662234
units def: 100875
parameter: 662613
parameter: 662377
parameter: 662437
parameter: 662473
parameter: 662499
rule: 662242
parameter: 662411
parameter: 662383
parameter: 662417
parameter: 662523
parameter: 662453
units def: 100935
parameter: 662373
parameter: 662399
parameter: 662459
parameter: 662565
parameter: 662495
rule: 662285
units def: 100899
rule: 662264
parameter: 662423
parameter: 662545
parameter: 662525
parameter: 662429
parameter: 662359
parameter: 662465

662455
constant: true
units: 101055
value: 0.14
name: kDNA_onDT5a
type: Parameter

662561
constant: false
units: 100899
value: NaN
name: Qp
type: Parameter

101043
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

100838
unit: 100862
unit: 100850
name: ng_ml
type: SBMLUnitsDef

662419
constant: true
units: 101055
value: 0.14
name: kDD_on
type: Parameter

662445
constant: true
units: 101031
value: 0.2
name: kDNA_offDDsec
type: Parameter

101116
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

662621
constant: false
units: 100778
value: NaN
name: CTbf
type: Parameter

662569
constant: true
units: 100935
value: 3.02
name: k5a
type: Parameter

662369
constant: false
units: 100778
value: 0.0
name: CD_A
type: Parameter

662465
constant: false
units: 100778
value: 0.0
name: CDTsec
type: Parameter

662389
constant: false
units: 100814
value: 0.0
name: ATif
type: Parameter

662495
constant: false
units: 100778
value: 0.0
name: CTTcp
type: Parameter

662549
constant: false
units: 100935
value: NaN
name: A
type: Parameter

662641
constant: true
units: 100778
value: 0.075
name: CDNAcd
type: Parameter

662503
constant: false
units: 100778
value: NaN
name: T
type: Parameter

662655
constant: true
units: litre
value: 5.08E-5
name: VPC2
type: Parameter

662535
constant: false
units: 100814
value: 0.0
name: ALH
type: Parameter

662475
constant: true
units: 101031
value: 5.6
name: kDNA_offDTcp
type: Parameter

101068
exponent: -1.0
scale: -9
multipler: 1.0
kind: MOLE
type: SBMLUnit

662485
constant: true
units: 101055
value: 0.14
name: kDNA_onTTcd
type: Parameter

101080
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

662379
constant: false
units: 100778
value: NaN
name: CAf
type: Parameter

662541
constant: true
units: 100935
value: 1.68E-4
name: kLH3
type: Parameter

662359
constant: true
units: 100935
value: 0.17
name: k2T
type: Parameter

662555
constant: true
units: 100935
value: 68.15
name: k1R
type: Parameter

662605
constant: true
value: 3.65
name: Vmax1
type: Parameter

662635
constant: true
units: 100778
value: 307.29
name: CTst
type: Parameter

662393
constant: false
units: 100778
value: NaN
name: CTtv
type: Parameter

662517
constant: false
units: 100778
value: NaN
name: CDNAsecf
type: Parameter

662473
constant: true
units: 101055
value: 0.14
name: kDNA_onDTcp
type: Parameter

101092
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

100923
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND
type: SBMLUnit

662373
constant: true
units: 101031
value: 5407.0
name: kDA_off
type: Parameter

662599
constant: true
units: 100778
value: 40.0
name: km5alpha
type: Parameter

662625
constant: false
units: 100778
value: NaN
name: CDbf
type: Parameter

662529
constant: false
units: dimensionless
value: NaN
name: DNAo5a
type: Parameter

662487
constant: true
units: 101031
value: 1.2
name: kDNA_offTTcd
type: Parameter

662387
constant: false
units: 100778
value: NaN
name: CDlf
type: Parameter

662539
constant: true
units: 100935
value: 0.026
name: kLH2
type: Parameter

662615
constant: true
value: 2.0
name: PDl
type: Parameter

662513
constant: false
units: 100778
value: NaN
name: CRf
type: Parameter

662401
constant: true
units: 101055
value: 0.14
name: kTR_on
type: Parameter

662579
constant: true
units: 100995
value: 8.44E-6
name: ksec
type: Parameter

662431
constant: true
units: 101055
value: 0.14
name: kDNA_onDD5a
type: Parameter

662429
constant: false
units: 100778
value: 0.0
name: CDD5a
type: Parameter

662585
constant: false
units: 100899
value: NaN
name: Qb
type: Parameter

662439
constant: true
units: 101031
value: 0.1
name: kDNA_offDDcd
type: Parameter

662421
constant: true
units: 101031
value: 3.13
name: kDD_off
type: Parameter

662571
constant: false
units: litre
value: 0.0
name: VPC1
type: Parameter

662411
constant: false
units: 100778
value: 0.0
name: CDT
type: Parameter

662523
constant: false
units: dimensionless
value: NaN
name: DNAocp
type: Parameter

662367
constant: true
units: 101031
value: 8131.0
name: kTA_off
type: Parameter

662391
constant: false
units: 100814
value: 0.0
name: ATst
type: Parameter

662553
constant: false
units: 100814
value: 0.0
name: AR
type: Parameter

662647
constant: true
units: 100778
value: 0.075
name: CDNA5a
type: Parameter

662543
constant: true
units: 101031
value: 0.8
name: kLH4
type: Parameter

662563
constant: true
units: 101031
value: 73.84
name: kQp
type: Parameter

662447
constant: false
units: 100778
value: 0.0
name: CDDcp
type: Parameter

662657
constant: true
units: litre
value: 3.08E-6
name: VPL2
type: Parameter

662533
constant: false
units: 100814
value: 0.0
name: ADb
type: Parameter

662453
constant: false
units: 100778
value: 0.0
name: CDT5a
type: Parameter

662407
constant: true
units: 101055
value: 0.053
name: kDR_on
type: Parameter

662519
constant: false
units: 100778
value: NaN
name: CDNA5af
type: Parameter

100862
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE
type: SBMLUnit

662603
constant: true
units: 100899
value: 1000.0
name: mu
type: Parameter

662493
constant: true
units: 101031
value: 2.4
name: kDNA_offTTsec
type: Parameter

662591
constant: false
units: 100899
value: NaN
name: Qbt
type: Parameter

662399
constant: false
units: 100778
value: 0.0
name: CT_R
type: Parameter

662509
constant: false
units: 100778
value: NaN
name: D
type: Parameter

100995
unit: 101019
unit: 101007
name: kg_hr
type: SBMLUnitsDef

662467
constant: true
units: 101055
value: 0.14
name: kDNA_onDTsec
type: Parameter

662375
constant: false
units: 100778
value: NaN
name: CTblf
type: Parameter

662489
constant: false
units: 100778
value: 0.0
name: CTTsec
type: Parameter

100875
unit: 100887
name: hour
type: SBMLUnitsDef

662525
constant: false
units: dimensionless
value: NaN
name: DNAosec
type: Parameter

662527
constant: false
units: dimensionless
value: NaN
name: DNAocd
type: Parameter

662627
constant: true
units: 100778
value: 0.59
name: CDbl
type: Parameter

662461
constant: true
units: 101055
value: 0.14
name: kDNA_onDTcd
type: Parameter

662471
constant: false
units: 100778
value: 0.0
name: CDTcp
type: Parameter

100911
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

662613
constant: true
value: 2.75
name: PTl
type: Parameter

662499
constant: true
units: 101031
value: 8.4
name: kDNA_offTTcp
type: Parameter

662385
constant: false
units: 100778
value: NaN
name: CTlf
type: Parameter

662583
constant: false
units: litre
value: NaN
name: Vp
type: Parameter

662433
constant: true
units: 101031
value: 0.07
name: kDNA_offDD5a
type: Parameter

662427
constant: true
units: 101031
value: 3.13
name: kTT_off
type: Parameter

100778
unit: 100802
unit: 100790
name: nM
type: SBMLUnitsDef

662511
constant: true
units: dimensionless
value: 1.0
name: NDp
type: Parameter

662413
constant: true
units: 101055
value: 0.14
name: kDT_on
type: Parameter

662573
constant: true
units: 100995
value: 1.17E-7
name: kcpl
type: Parameter

662459
constant: false
units: 100778
value: 0.0
name: CDTcd
type: Parameter

662551
constant: false
units: 100935
value: NaN
name: B
type: Parameter

662365
constant: true
units: 101055
value: 0.18
name: kTA_on
type: Parameter

662645
constant: true
units: 100778
value: 0.075
name: CDNAcp
type: Parameter

662545
constant: true
units: dimensionless
value: 0.25
name: alpha_T
type: Parameter

662441
constant: false
units: 100778
value: 0.0
name: CDDsec
type: Parameter

662469
constant: true
units: 101031
value: 1.6
name: kDNA_offDTsec
type: Parameter

662651
constant: true
units: 100778
value: 0.019884
name: CDb
type: Parameter

662609
constant: true
units: dimensionless
value: 1.96
name: PTif
type: Parameter

662631
constant: true
units: 100778
value: 9.92
name: CTl
type: Parameter

662565
constant: false
units: litre
value: NaN
name: Vpc
type: Parameter

662559
constant: false
units: 100778
value: NaN
name: CR
type: Parameter

662451
constant: true
units: 101031
value: 0.7
name: kDNA_offDDcp
type: Parameter

662531
constant: false
units: 100814
value: 0.0
name: ATb
type: Parameter

662659
constant: true
units: 100778
value: 11.38
name: CTp
type: Parameter

662449
constant: true
units: 101055
value: 0.14
name: kDNA_onDDcp
type: Parameter

662491
constant: true
units: 101055
value: 0.14
name: kDNA_onTTsec
type: Parameter

662593
constant: true
units: 100899
value: 6.08
name: Qc
type: Parameter

662601
constant: true
units: dimensionless
value: 0.56
name: ts
type: Parameter

662479
constant: true
units: 101055
value: 0.14
name: kDNA_onTT5a
type: Parameter

662409
constant: true
units: 101031
value: 0.018
name: kDR_off
type: Parameter

662507
constant: false
units: 100778
value: NaN
name: CDpf
type: Parameter

662397
constant: false
units: 100814
value: 0.0
name: ADp
type: Parameter

101007
exponent: 1.0
scale: 0
multipler: 1.0
kind: KILOGRAM
type: SBMLUnit

662481
constant: true
units: 101031
value: 0.84
name: kDNA_offTT5a
type: Parameter