623082
constant: false
units: dimensionless
value: NaN
name: lambda_A_1
type: Parameter

623092
constant: true
units: 960682
value: 120.0
name: k_Ca_on
type: Parameter

623107
constant: true
units: dimensionless
value: 1.0
name: v
type: Parameter

623098
constant: true
units: 960682
value: 8.0
name: h
type: Parameter

623094
constant: true
units: 960682
value: 50.0
name: k_Ca_off
type: Parameter

623109
constant: false
units: 960682
value: NaN
name: k_u_on
type: Parameter

623119
constant: false
units: 960682
value: NaN
name: k_off
type: Parameter

623080
constant: false
units: dimensionless
value: NaN
name: lambda_D
type: Parameter

623086
constant: false
units: dimensionless
value: NaN
name: Ca
type: Parameter

623077
constant: false
units: dimensionless
value: NaN
name: lambda_off
type: Parameter

623074
constant: false
units: dimensionless
value: 0.0
name: A_1
type: Parameter

623112
constant: false
units: 960682
value: NaN
name: k_w_on
type: Parameter

623089
constant: true
units: 960682
value: 0.0
name: k_0_on
type: Parameter

623070
constant: true
units: dimensionless
value: 1.0
name: R_T
type: Parameter

623116
constant: false
units: 960682
value: NaN
name: f_prime
type: Parameter

623104
constant: true
units: dimensionless
value: 1.0
name: u
type: Parameter

623097
constant: true
units: 960682
value: 400.0
name: f_prime_0
type: Parameter

623106
constant: true
units: dimensionless
value: 1.0
name: w
type: Parameter

623083
constant: false
units: dimensionless
value: NaN
name: lambda_A_2
type: Parameter

960682
unit: 960694
name: per_second
type: SBMLUnitsDef

623118
constant: false
units: 960682
value: NaN
name: k_on
type: Parameter

623095
constant: true
units: 960682
value: 50.0
name: f_0
type: Parameter

623110
constant: false
units: 960682
value: NaN
name: k_u_off
type: Parameter

623100
constant: true
units: 960682
value: 6.0
name: h_prime
type: Parameter

623085
constant: false
units: dimensionless
value: NaN
name: lambda_A2_cyc
type: Parameter

623076
constant: false
units: dimensionless
value: 0.0
name: A_2
type: Parameter

960694
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

623069
constant: false
units: dimensionless
value: NaN
name: F
type: Parameter

623101
constant: true
units: 960682
value: 4.0
name: g
type: Parameter

623073
constant: false
units: dimensionless
value: 0.0
name: D
type: Parameter

623088
constant: false
units: dimensionless
value: NaN
name: Ca_50
type: Parameter

MODEL7909395757
parameter: 623101
rule: 623056
parameter: 623074
parameter: 623094
parameter: 623095
rule: 623038
parameter: 623082
substance units: 106194
parameter: 623089
parameter: 623119
rule: 623047
rule: 623061
parameter: 623076
rule: 623067
parameter: 623077
parameter: 623106
parameter: 623107
rule: 623059
parameter: 623104
parameter: 623113
rule: 623064
parameter: 623098
parameter: 623085
parameter: 623086
units def: 960682
parameter: 623092
name: Razumova2000_MyofilamentContractileBehaviour
parameter: 623079
parameter: 623073
parameter: 623110
rule: 623039
parameter: 623080
parameter: 623088
compartment: 623036
parameter: 623118
rule: 623062
parameter: 623091
rule: 623043
rule: 623055
parameter: 623103
parameter: 623100
rule: 623040
type: SBMLModel
parameter: 623112
rule: 623065
parameter: 623097
rule: 623052
parameter: 623069
volume units: metaid_0000217
curated: false
is described by: http://identifiers.org/pubmed/10827989
length unit: length
parameter: 623115
parameter: 623116
rule: 623050
parameter: 623083
parameter: 623070
time units: 945099
parameter: 623071
rule: 623046
rule: 623041
rule: 623058
parameter: 623109
rule: 623053
area units: area
notes: This a model from the article: Different myofilament nearest-neighbor interactions have distinctive effects on contractile behavior. Razumova MV, Bukatina AE, Campbell KB. Biophys J. 2000;78(6):3120-37 10827989 , Abstract: Cooperativity in contractile behavior of myofilament systems almost assuredly arises because of interactions between neighboring sites. These interactions may be of different kinds. Tropomyosin thin-filament regulatory units may have neighbors in steric blocking positions (off) or steric permissive positions (on). The position of these neighbors influence the tendency for the regulatory unit to assume the on or off state. Likewise, the tendency of a myosin cross-bridge to achieve a force-bearing state may be influenced by whether neighboring cross-bridges are in force-bearing states. Also, a cross-bridge in the force-bearing state may influence the tendency of a regulatory unit to enter the on state. We used a mathematical model to examine the influence of each of these three kinds of neighbor interactions on the steady-state force-pCa relation and on the dynamic force redevelopment process. Each neighbor interaction was unique in its effects on maximal Ca(2+)-activated force, position, and symmetry of the force-pCa curve and on the Hill coefficient. Also, each neighbor interaction had a distinctive effect on the time course of force development as assessed by its rate coefficient, k(dev). These diverse effects suggest that variations in all three kinds of nearest-neighbor interactions may be responsible for a wide variety of currently unexplained observations of myofilament contractile behavior. This model was taken from the CellML repository and automatically converted to SBML. The original model was: razumova, bukatina, campbell. (2000) - version03 The original CellML model was created by: Nunns, Geoffrey, Rogan gnunns1@jhem.jhu.edu The University of Auckland Auckland Bioengineering Institute This model originates from BioModels Database: A Dat…
rule: 623049
rule: 623044

623113
constant: false
units: 960682
value: NaN
name: k_w_off
type: Parameter

623079
constant: false
units: dimensionless
value: NaN
name: lambda_on
type: Parameter

623115
constant: false
units: 960682
value: NaN
name: f
type: Parameter

623071
constant: false
units: dimensionless
value: NaN
name: R_off
type: Parameter

623103
constant: true
units: dimensionless
value: 1.0
name: n_H
type: Parameter

623091
constant: true
units: 960682
value: 100.0
name: k_0_off
type: Parameter

623036
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment