686041
constant: true
units: 914079
value: 6.0
name: omega_h
type: Parameter

685980
constant: true
units: 914079
value: -34.0
name: theta_m
type: Parameter

686001
constant: false
units: 914103
value: NaN
name: i_K
type: Parameter

685990
constant: false
units: 914055
value: NaN
name: tau_n
type: Parameter

686035
constant: false
units: 914055
value: NaN
name: tau_h
type: Parameter

914128
unit: 914141
name: nanoS
type: SBMLUnitsDef

685967
constant: false
units: 914079
value: NaN
name: V
type: Parameter

686051
constant: true
units: 914079
value: -65.0
name: E_L
type: Parameter

686026
constant: true
units: 914079
value: -40.0
name: theta_m
type: Parameter

686045
constant: true
units: 914055
value: NaN
name: time
type: Parameter

686021
constant: false
units: 914103
value: NaN
name: i_NaP
type: Parameter

686012
constant: true
units: 914055
value: 10.0
name: tau_n_max
type: Parameter

MODEL7891585309
parameter: 685968
parameter: 685978
parameter: 686021
parameter: 686012
parameter: 685996
parameter: 686003
parameter: 685972
parameter: 686041
compartment: 685933
parameter: 686017
curated: false
parameter: 685986
rule: 685964
volume units: metaid_0000217
parameter: 686000
parameter: 686032
parameter: 686037
parameter: 686014
units def: 914103
rule: 685954
rule: 685944
parameter: 686052
parameter: 686035
parameter: 686045
parameter: 686028
parameter: 685982
parameter: 686043
parameter: 686019
rule: 685936
time units: 914178
parameter: 685988
parameter: 685998
name: Butera1999_Bursting_Pacemaker_Neuron_Model_1
parameter: 685980
parameter: 685990
type: SBMLModel
rule: 685950
rule: 685940
parameter: 686039
parameter: 686049
rule: 685946
is described by: http://identifiers.org/pubmed/10400966
units def: 914055
parameter: 685974
parameter: 686033
rule: 685960
substance units: 106194
parameter: 686051
parameter: 685967
rule: 685966
parameter: 686056
parameter: 686010
parameter: 686015
parameter: 686025
parameter: 686054
parameter: 686047
units def: 914079
length unit: length
parameter: 685984
parameter: 685994
parameter: 686001
rule: 685942
parameter: 686030
rule: 685956
parameter: 686023
rule: 685938
parameter: 686006
units def: 914128
parameter: 685970
units def: 914154
rule: 685962
notes: This is the model without the slow potassium current, model 1, described in the article: Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons. Butera RJ Jr, Rinzel J, Smith JC. J Neurophysiol. 1999 Jul;82(1):382-97. Pubmed ID: 10400966 , full text at the Journal of Neurophysiology . Abstract: A network of oscillatory bursting neurons with excitatory coupling is hypothesized to define the primary kernel for respiratory rhythm generation in the pre-Bötzinger complex (pre-BötC) in mammals. Two minimal models of these neurons are proposed. In model 1, bursting arises via fast activation and slow inactivation of a persistent Na+ current INaP-h. In model 2, bursting arises via a fast-activating persistent Na+ current INaP and slow activation of a K+ current IKS. In both models, action potentials are generated via fast Na+ and K+ currents. The two models have few differences in parameters to facilitate a rigorous comparison of the two different burst-generating mechanisms. Both models are consistent with many of the dynamic features of electrophysiological recordings from pre-BötC oscillatory bursting neurons in vitro, including voltage-dependent activity modes (silence, bursting, and beating), a voltage-dependent burst frequency that can vary from 0.05 to > 1 Hz, and a decaying spike frequency during bursting. These results are robust and persist across a wide range of parameter values for both models. However, the dynamics of model 1 are more consistent with experimental data in that the burst duration decreases as the baseline membrane potential is depolarized and the model has a relatively flat membrane potential trajectory during the interburst interval. We propose several experimental tests to demonstrate the validity of either model and to differentiate between the two mechanisms. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Butera, Rinzel, Smith, 1999 vers…
parameter: 686007
parameter: 685992
area units: area
parameter: 686008
parameter: 685976
units def: 914178
parameter: 686026
rule: 685952

685970
constant: true
units: 914103
value: 0.0
name: i_app
type: Parameter

914067
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

685974
constant: true
units: 914079
value: 50.0
name: E_Na
type: Parameter

686037
constant: true
units: 914055
value: 10000.0
name: tau_h_max
type: Parameter

686054
constant: true
units: 914128
value: 0.0
name: g_tonic_e
type: Parameter

686008
constant: false
units: dimensionless
value: NaN
name: n_infinity
type: Parameter

685994
constant: true
units: 914079
value: -29.0
name: theta_n
type: Parameter

685968
constant: true
units: 914154
value: 21.0
name: C
type: Parameter

686017
constant: true
units: 914079
value: NaN
name: V
type: Parameter

685998
constant: true
units: 914079
value: NaN
name: V
type: Parameter

685933
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

914141
exponent: 1.0
scale: -9
multipler: 1.0
kind: SIEMENS
type: SBMLUnit

685988
constant: false
units: dimensionless
value: NaN
name: n_infinity
type: Parameter

686000
constant: true
units: 914055
value: NaN
name: time
type: Parameter

914154
unit: 914166
name: picoF
type: SBMLUnitsDef

686030
constant: true
units: 914079
value: NaN
name: V
type: Parameter

685978
constant: false
units: dimensionless
value: NaN
name: m_infinity
type: Parameter

685984
constant: true
units: 914079
value: NaN
name: V
type: Parameter

686003
constant: true
units: 914128
value: 11.2
name: g_K
type: Parameter

686010
constant: false
units: 914055
value: NaN
name: tau_n
type: Parameter

686023
constant: true
units: 914128
value: 2.8
name: g_NaP
type: Parameter

686043
constant: true
units: 914079
value: NaN
name: V
type: Parameter

914178
unit: 914190
name: time
type: SBMLUnitsDef

914116
exponent: 1.0
scale: -9
multipler: 1.0
kind: AMPERE
type: SBMLUnit

686007
constant: false
units: dimensionless
value: NaN
name: n
type: Parameter

914190
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

685992
constant: true
units: 914055
value: 10.0
name: tau_n_max
type: Parameter

686033
constant: false
units: dimensionless
value: NaN
name: h_infinity
type: Parameter

686047
constant: false
units: 914103
value: NaN
name: i_L
type: Parameter

686014
constant: true
units: 914079
value: -29.0
name: theta_n
type: Parameter

686028
constant: true
units: 914079
value: -6.0
name: omega_m
type: Parameter

685976
constant: true
units: 914128
value: 28.0
name: g_Na
type: Parameter

686049
constant: true
units: 914128
value: 2.8
name: g_L
type: Parameter

685972
constant: false
units: 914103
value: NaN
name: i_Na
type: Parameter

686039
constant: true
units: 914079
value: -48.0
name: theta_h
type: Parameter

686052
constant: true
units: 914103
value: NaN
name: i_tonic_e
type: Parameter

686006
constant: true
units: 914079
value: -85.0
name: E_K
type: Parameter

914079
unit: 914091
name: millivolt
type: SBMLUnitsDef

685986
constant: false
units: dimensionless
value: NaN
name: n
type: Parameter

914091
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

686032
constant: false
units: dimensionless
value: NaN
name: h
type: Parameter

686025
constant: false
units: dimensionless
value: NaN
name: m_infinity
type: Parameter

914055
unit: 914067
name: millisecond
type: SBMLUnitsDef

686019
constant: true
units: 914055
value: NaN
name: time
type: Parameter

685996
constant: true
units: 914079
value: -4.0
name: omega_n
type: Parameter

686056
constant: true
units: 914079
value: 0.0
name: E_syn_e
type: Parameter

914166
exponent: 1.0
scale: -12
multipler: 1.0
kind: FARAD
type: SBMLUnit

685982
constant: true
units: 914079
value: -5.0
name: omega_m
type: Parameter

686015
constant: true
units: 914079
value: -4.0
name: omega_n
type: Parameter

914103
unit: 914116
name: picoA
type: SBMLUnitsDef