103798
constant: true
units: dimensionless
value: 5.0
name: v_cytver
type: Parameter

103784
constant: false
units: 891161
value: NaN
name: j_er
type: Parameter

891250
unit: 891263
name: per_nanosiemens
type: SBMLUnitsDef

103718
constant: true
units: 891276
value: 3.382
name: beta_h_max
type: Parameter

103658
constant: false
units: 891113
value: -75.0
name: V_m
type: Parameter

891263
exponent: -1.0
scale: -9
multipler: 1.0
kind: SIEMENS
type: SBMLUnit

103854
constant: true
units: 891276
value: 0.09616
name: beta_n_max
type: Parameter

891412
exponent: 1.0
scale: 3
multipler: 1.0
kind: JOULE
type: SBMLUnit

103728
constant: true
units: 891089
value: NaN
name: time
type: Parameter

103670
constant: false
units: dimensionless
value: NaN
name: H_0
type: Parameter

103802
constant: false
units: 891224
value: NaN
name: g_Ca
type: Parameter

103702
constant: true
units: 891089
value: NaN
name: time
type: Parameter

103664
constant: true
units: 891161
value: 2.0
name: I_mag
type: Parameter

103764
constant: true
units: 891364
value: NaN
name: RT
type: Parameter

891376
exponent: 1.0
scale: 0
multipler: 1.0
kind: JOULE
type: SBMLUnit

103712
constant: false
units: 891276
value: NaN
name: alpha_h
type: Parameter

103778
constant: false
units: 891161
value: NaN
name: j_mem
type: Parameter

103684
constant: true
units: 891113
value: NaN
name: V_m
type: Parameter

891460
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

103812
constant: true
units: 891089
value: NaN
name: time
type: Parameter

103732
constant: false
units: 891161
value: NaN
name: I_KCa
type: Parameter

891364
unit: 891388
unit: 891376
name: joule_per_mole
type: SBMLUnitsDef

103752
constant: true
units: dimensionless
value: 0.84
name: d_1
type: Parameter

103770
constant: true
units: dimensionless
value: 0.18
name: kd
type: Parameter

891125
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

891052
unit: 891076
unit: 891064
name: kilocoulombs_per_mole
type: SBMLUnitsDef

103742
constant: true
units: dimensionless
value: NaN
name: c
type: Parameter

103678
constant: true
units: 891113
value: 50.0
name: E_Na
type: Parameter

103722
constant: true
units: 891250
value: 15.0
name: R_s
type: Parameter

103844
constant: true
units: 891113
value: 7.0
name: V_alpha_n
type: Parameter

891315
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

103690
constant: true
units: 891113
value: 18.0
name: V_beta_m
type: Parameter

103708
constant: true
units: 891113
value: 14.7
name: V_alpha_h
type: Parameter

103698
constant: true
units: 891276
value: 2.081
name: beta_m_max
type: Parameter

103834
constant: false
units: dimensionless
value: 0.0
name: n
type: Parameter

891448
exponent: 1.0
scale: -9
multipler: 1.0
kind: SIEMENS
type: SBMLUnit

103790
constant: true
units: 891161
value: 0.4
name: k_serca
type: Parameter

891211
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

103786
constant: true
units: dimensionless
value: 4.5E-6
name: alpha
type: Parameter

103796
constant: true
units: 891186
value: 0.01
name: f_cyt
type: Parameter

103852
constant: true
units: 891328
value: 0.0229
name: alpha_n_max
type: Parameter

103692
constant: false
units: 891276
value: NaN
name: alpha_m
type: Parameter

103766
constant: false
units: dimensionless
value: NaN
name: w
type: Parameter

103700
constant: false
units: dimensionless
value: 1.0
name: h
type: Parameter

103662
constant: false
units: 891161
value: NaN
name: I_stim
type: Parameter

891388
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

103828
constant: false
units: 891161
value: NaN
name: I_K
type: Parameter

103672
constant: false
units: dimensionless
value: NaN
name: H_1
type: Parameter

103800
constant: false
units: 891161
value: NaN
name: I_Ca
type: Parameter

891472
unit: 891485
name: time
type: SBMLUnitsDef

103682
constant: true
units: 891089
value: NaN
name: time
type: Parameter

103716
constant: true
units: 891276
value: 0.0156
name: alpha_h_max
type: Parameter

103714
constant: false
units: 891276
value: NaN
name: beta_h
type: Parameter

891400
unit: 891424
unit: 891412
name: kilojoule_per_mole
type: SBMLUnitsDef

891101
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

103808
constant: false
units: dimensionless
value: 0.0
name: d
type: Parameter

103776
constant: false
units: dimensionless
value: 200.0
name: cer
type: Parameter

103814
constant: false
units: 891276
value: NaN
name: alpha_d
type: Parameter

891328
unit: 891352
unit: 891340
name: per_millivolt_per_millisecond
type: SBMLUnitsDef

891485
exponent: 1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

103720
constant: false
units: 891161
value: NaN
name: I_T
type: Parameter

103734
constant: true
units: 891224
value: 0.5
name: g_KCa
type: Parameter

891352
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

891113
unit: 891125
name: millivolt
type: SBMLUnitsDef

103754
constant: true
units: dimensionless
value: 1.0
name: d_2
type: Parameter

891276
unit: 891289
name: per_millisecond
type: SBMLUnitsDef

103740
constant: true
units: 891113
value: NaN
name: V_m
type: Parameter

891198
exponent: -1.0
scale: -12
multipler: 1.0
kind: AMPERE
type: SBMLUnit

103846
constant: true
units: 891113
value: 40.0
name: V_beta_n
type: Parameter

103848
constant: false
units: 891276
value: NaN
name: alpha_n
type: Parameter

103748
constant: false
units: 891276
value: NaN
name: beta_Vm
type: Parameter

103832
constant: true
units: 891224
value: 0.415
name: g_K
type: Parameter

103577
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0
type: Compartment

103694
constant: false
units: 891276
value: NaN
name: beta_m
type: Parameter

891174
exponent: 1.0
scale: -12
multipler: 1.0
kind: AMPERE
type: SBMLUnit

103806
constant: true
units: 891113
value: 50.0
name: E_Ca
type: Parameter

MODEL7817907010
parameter: 103806
parameter: 103846
parameter: 103852
parameter: 103668
units def: 891436
notes: This a model from the article: Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells. Wang YJ, Lin MW, Lin AA, Wu SN. Life Sci. (2008) 82(1-2) pp 11-20; Pubmed ID: 18068197 , Abstract: Riluzole is known to be of therapeutic use in the management of amyotrophic lateral sclerosis. In this study, we investigated the effects of riluzole on ion currents in cultured differentiated human skeletal muscle cells (dHSkMCs). Western blotting revealed the protein expression of alpha-subunits for both large-conductance Ca2+-activated K+ (BK(Ca)) channel and Na+ channel (Na(v)1.5) in these cells. Riluzole could reduce the frequency of spontaneous beating in dHSkMCs. In whole-cell configuration, riluzole suppressed voltage-gated Na+ current (I(Na)) in a concentration-dependent manner with an IC50 value of 2.3 microM. Riluzole (10 microM) also effectively increased Ca2+-activated K+ current (I(K(Ca))) which could be reversed by iberiotoxin (200 nM) and paxilline (1 microM), but not by apamin (200 nM). In inside-out patches, when applied to the inside of the cell membrane, riluzole (10 microM) increased BK(Ca)-channel activity with a decrease in mean closed time. Simulation studies also unraveled that both decreased conductance of I(Na) and increased conductance of I(K(Ca)) utilized to mimic riluzole actions in skeletal muscle cells could combine to decrease the amplitude of action potentials and increase the repolarization of action potentials. Taken together, inhibition of I(Na) and stimulation of BK(Ca)-channel activity caused by this drug are partly, if not entirely, responsible for its muscle relaxant actions in clinical setting. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wang_Lin_Lin_Wu, 1999, version02 The original CellML model was created by: Nunns, Geoffrey, Rogan gnunns1(at)jhem.jhu.edu The University of Auckland Auckland Bio…
parameter: 103682
rule: 103644
parameter: 103674
compartment: 103577
parameter: 103832
rule: 103614
parameter: 103794
parameter: 103786
parameter: 103800
parameter: 103840
rule: 103640
parameter: 103748
parameter: 103766
rule: 103610
parameter: 103662
parameter: 103780
parameter: 103820
parameter: 103838
units def: 891161
parameter: 103716
parameter: 103774
units def: 891137
parameter: 103818
parameter: 103696
parameter: 103736
type: SBMLModel
parameter: 103742
parameter: 103760
parameter: 103808
rule: 103632
rule: 103598
rule: 103602
parameter: 103722
parameter: 103684
parameter: 103676
units def: 891052
parameter: 103812
parameter: 103834
parameter: 103690
parameter: 103730
rule: 103594
units def: 891472
parameter: 103802
parameter: 103670
parameter: 103710
parameter: 103728
parameter: 103798
parameter: 103768
units def: 891276
parameter: 103664
parameter: 103782
parameter: 103822
parameter: 103708
rule: 103646
name: Wang2008_Rilusole_SkeletalMuscleCells
rule: 103608
parameter: 103738
time units: 891472
rule: 103586
parameter: 103770
parameter: 103762
units def: 891089
parameter: 103754
parameter: 103724
is described by: http://identifiers.org/pubmed/18068197
rule: 103582
rule: 103638
parameter: 103814
units def: 891250
rule: 103628
parameter: 103688
parameter: 103658
parameter: 103804
parameter: 103672

103788
constant: true
units: dimensionless
value: 0.2
name: k_pmca
type: Parameter

103826
constant: true
units: 891224
value: 0.0024
name: g_Lmax
type: Parameter

103836
constant: true
units: 891089
value: NaN
name: time
type: Parameter

103768
constant: true
units: 891089
value: NaN
name: time
type: Parameter

103850
constant: false
units: 891276
value: NaN
name: beta_n
type: Parameter

103816
constant: false
units: 891276
value: NaN
name: beta_d
type: Parameter

103668
constant: true
units: 891089
value: 6.0
name: t_1
type: Parameter

891064
exponent: 1.0
scale: 3
multipler: 1.0
kind: COULOMB
type: SBMLUnit

103680
constant: false
units: dimensionless
value: 0.0
name: m
type: Parameter

103760
constant: true
units: 891276
value: 0.48
name: a_bar
type: Parameter

103774
constant: false
units: dimensionless
value: 0.15
name: c
type: Parameter

103726
constant: false
units: 891113
value: -70.0
name: V_T
type: Parameter

103704
constant: true
units: 891113
value: NaN
name: V_m
type: Parameter

103820
constant: false
units: dimensionless
value: NaN
name: d_infinity
type: Parameter

103688
constant: true
units: 891113
value: 10.0
name: V_alpha_m
type: Parameter

103674
constant: false
units: 891161
value: NaN
name: I_Na
type: Parameter

103660
constant: true
units: 891137
value: 0.009
name: C_m
type: Parameter

103736
constant: false
units: dimensionless
value: 0.15
name: o
type: Parameter

891424
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

103810
constant: true
units: 891113
value: NaN
name: V_m
type: Parameter

891340
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit

891161
unit: 891174
name: picoampere
type: SBMLUnitsDef

891149
exponent: 1.0
scale: -12
multipler: 1.0
kind: FARAD
type: SBMLUnit

103794
constant: true
units: 891186
value: 0.01
name: f_er
type: Parameter

103756
constant: true
units: dimensionless
value: 0.18
name: k_1
type: Parameter

103840
constant: true
units: 891113
value: -40.0
name: E_n
type: Parameter

103830
constant: true
units: 891113
value: -70.0
name: E_K
type: Parameter

103780
constant: false
units: 891161
value: NaN
name: j_leak
type: Parameter

103746
constant: false
units: 891276
value: NaN
name: alpha_Vm
type: Parameter

103655
constant: true
units: 891364
value: 2577.0
name: RT
type: Parameter

103824
constant: true
units: 891113
value: -75.0
name: E_L
type: Parameter

103696
constant: true
units: 891328
value: 0.208
name: alpha_m_max
type: Parameter

891224
unit: 891237
name: nanosiemens
type: SBMLUnitsDef

103818
constant: false
units: 891089
value: NaN
name: tau_d
type: Parameter

891302
unit: 891315
name: per_millivolt
type: SBMLUnitsDef

891186
unit: 891211
unit: 891198
name: per_picoampere_per_millisecond
type: SBMLUnitsDef

103838
constant: true
units: 891113
value: NaN
name: V_m
type: Parameter

103666
constant: true
units: 891089
value: 5.0
name: t_0
type: Parameter

103710
constant: true
units: 891113
value: 7.6
name: V_beta_h
type: Parameter

103762
constant: true
units: 891276
value: 0.28
name: b_bar
type: Parameter

103772
constant: true
units: dimensionless
value: NaN
name: c
type: Parameter

103804
constant: true
units: 891436
value: 0.05
name: g_Ca0
type: Parameter

891076
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE
type: SBMLUnit

103686
constant: true
units: 891113
value: -42.0
name: E_m
type: Parameter

103724
constant: true
units: 891137
value: 0.04
name: C_t
type: Parameter

891436
unit: 891460
unit: 891448
name: nanosiemens_per_millivolt
type: SBMLUnitsDef

103822
constant: false
units: 891161
value: NaN
name: I_L
type: Parameter

103706
constant: true
units: 891113
value: -41.0
name: E_h
type: Parameter

891089
unit: 891101
name: millisecond
type: SBMLUnitsDef

103738
constant: true
units: 891089
value: NaN
name: time
type: Parameter

103750
constant: false
units: 891089
value: NaN
name: tau_Vm
type: Parameter

891237
exponent: 1.0
scale: -9
multipler: 1.0
kind: SIEMENS
type: SBMLUnit

103676
constant: true
units: 891224
value: 0.45
name: g_Na
type: Parameter

103730
constant: true
units: 891113
value: NaN
name: V_m
type: Parameter

103758
constant: true
units: dimensionless
value: 0.011
name: k_2
type: Parameter

103792
constant: true
units: 891161
value: 5.0E-4
name: p_leak
type: Parameter

103744
constant: false
units: dimensionless
value: NaN
name: o_oinf
type: Parameter

103782
constant: false
units: 891161
value: NaN
name: j_serca
type: Parameter

891137
unit: 891149
name: picofarad
type: SBMLUnitsDef

103842
constant: true
units: 891113
value: -24.6
name: E_d
type: Parameter

891289
exponent: -1.0
scale: -3
multipler: 1.0
kind: SECOND
type: SBMLUnit