860308
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

metaid_0000142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: IkBp50p65
type: Species

metaid_0000005
constant: true
value: 1.0E-5
type: Parameter

860752
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

metaid_0000120
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: sa96_degraded
type: Species

metaid_0000015
constant: true
value: 0.5
type: Parameter

metaid_0000110
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: A20
type: Species

metaid_0000079
constant: true
value: 0.62
type: Parameter

metaid_0000152
kinetic law: 860668
modifier: 860656
modifier: 860644
product: 860632
reactant: 860620
fast: false
reversible: false
type: Reaction

860860
stoichiometry: 1.0
species: metaid_0000108
type: SpeciesReference

metaid_0000051
constant: true
value: 6.4E-5
type: Parameter

metaid_0000172
kinetic law: 861472
product: 861460
reactant: 861448
fast: false
reversible: false
type: Reaction

metaid_0000065
constant: true
value: 0.62
type: Parameter

860800
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

metaid_0000162
kinetic law: 861052
product: 861040
reactant: 861028
fast: false
reversible: false
type: Reaction

861652
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

861712
stoichiometry: 1.0
species: metaid_0000120
type: SpeciesReference

metaid_0000100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 3.33333333333333E-4
in compartment: metaid_0000099
name: FTAz
type: Species

metaid_0000091
constant: true
value: 6.66E-6
name: concentration of promoters
type: Parameter

metaid_0000025
constant: true
value: 0.0
type: Parameter

metaid_0000035
constant: true
value: 1.0E-4
type: Parameter

860272
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

860320
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000121
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: sa97_degraded
type: Species

metaid_0000006
constant: true
value: 0.1
type: Parameter

metaid_0000143
kinetic law: 860200
product: 860188
reactant: 860176
reactant: 860164
fast: false
reversible: false
type: Reaction

metaid_0000016
constant: true
value: 0.0
type: Parameter

metaid_0000111
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: mRNAA20
type: Species

metaid_0000153
kinetic law: 860704
product: 860692
reactant: 860680
fast: false
reversible: false
type: Reaction

860236
stoichiometry: 1.0
species: metaid_0000137
type: SpeciesReference

metaid_0000052
constant: true
value: 10.0
type: Parameter

861244
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000036
constant: true
value: 5.0E-4
type: Parameter

metaid_0000173
kinetic law: 861520
product: 861508
reactant: 861496
reactant: 861484
fast: false
reversible: false
type: Reaction

metaid_0000163
kinetic law: 861088
product: 861076
reactant: 861064
fast: false
reversible: false
type: Reaction

861544
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000066
constant: true
value: 4.8E-4
type: Parameter

861196
stoichiometry: 1.0
species: metaid_0000128
type: SpeciesReference

metaid_0000090
constant: true
value: 2.0E-4
type: Parameter

metaid_0000026
constant: true
value: 1.0E-4
type: Parameter

metaid_0000101
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: IkB_alpha
type: Species

metaid_0000003
constant: false
value: 0.0
type: Parameter

metaid_0000122
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: csa21_degraded
type: Species

metaid_0000094
constant: true
value: 6.7E-8
name: =k39*kr66*k70*P0/(k37*kf66*(k38+k39))
type: Parameter

861280
stoichiometry: 1.0
species: metaid_0000113
type: SpeciesReference

metaid_0000140
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000099
name: p65
type: Species

metaid_0000154
kinetic law: 860740
product: 860728
reactant: 860716
fast: false
reversible: false
type: Reaction

metaid_0000017
constant: true
value: 0.5
type: Parameter

861664
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

metaid_0000174
kinetic law: 861568
product: 861556
reactant: 861544
reactant: 861532
fast: false
reversible: false
type: Reaction

metaid_0000037
constant: true
value: 0.1
type: Parameter

metaid_0000102
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: csa17_degraded
type: Species

metaid_0000023
constant: true
value: 3.0E-4
type: Parameter

metaid_0000053
constant: true
value: 1.0E-4
type: Parameter

861700
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

861892
stoichiometry: 1.0
species: metaid_0000124
type: SpeciesReference

metaid_0000063
constant: true
value: 2.0E-4
type: Parameter

metaid_0000093
constant: true
value: 2.2925E-7
name: =k36*k39*P0*k34*kf68/(k37*kf64*(k38+k39))
type: Parameter

metaid_0000160
kinetic law: 860980
modifier: 860968
product: 860956
reactant: 860944
fast: false
reversible: false
type: Reaction

861820
stoichiometry: 1.0
species: metaid_0000122
type: SpeciesReference

metaid_0000123
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: csa18_degraded
type: Species

metaid_0000004
constant: true
value: 1.25E-4
type: Parameter

metaid_0000141
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: p150
type: Species

860476
stoichiometry: 1.0
species: metaid_0000131
type: SpeciesReference

metaid_0000018
constant: true
value: 0.0
type: Parameter

860332
stoichiometry: 1.0
species: metaid_0000139
type: SpeciesReference

metaid_0000155
kinetic law: 860776
product: 860764
reactant: 860752
fast: false
reversible: false
type: Reaction

860404
stoichiometry: 1.0
species: metaid_0000139
type: SpeciesReference

860260
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

metaid_0000054
constant: true
value: 0.016
type: Parameter

metaid_0000024
constant: true
value: 5.0E-7
type: Parameter

metaid_0000103
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: sa438_degraded
type: Species

metaid_0000038
constant: true
value: 5.0E-4
type: Parameter

metaid_0000175
kinetic law: 861604
product: 861592
reactant: 861580
fast: false
reversible: false
type: Reaction

861556
stoichiometry: 1.0
species: metaid_0000130
type: SpeciesReference

metaid_0000092
constant: true
value: 7.07E-5
name: =k43*k45*P0 / k46
type: Parameter

metaid_0000064
constant: true
value: 2.0E-4
type: Parameter

861880
stoichiometry: 1.0
species: metaid_0000131
type: SpeciesReference

metaid_0000161
kinetic law: 861016
product: 861004
reactant: 860992
fast: false
reversible: false
type: Reaction

metaid_0000124
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: csa9_degraded
type: Species

metaid_0000075
constant: true
value: 0.0038
type: Parameter

metaid_0000096
constant: true
value: 0.003
name: =kr66/kf66
type: Parameter

metaid_0000089
constant: true
value: 2.0E-4
type: Parameter

metaid_0000011
constant: true
value: 1.2
type: Parameter

metaid_0000180
kinetic law: 861796
product: 861784
reactant: 861772
fast: false
reversible: false
type: Reaction

metaid_0000114
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: IKKi
type: Species

metaid_0000029
constant: true
value: 5.0E-4
type: Parameter

861328
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

861917
persistant: true
initial value: true
type: Trigger

860824
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

metaid_0000166
kinetic law: 861208
product: 861196
reactant: 861184
reactant: 861172
fast: false
reversible: false
type: Reaction

metaid_0000176
kinetic law: 861640
product: 861628
reactant: 861616
fast: false
reversible: false
type: Reaction

861100
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000039
constant: true
value: 0.1
type: Parameter

860188
stoichiometry: 1.0
species: metaid_0000138
type: SpeciesReference

metaid_0000055
constant: true
value: 0.0053
type: Parameter

metaid_0000069
constant: true
value: 18.4
type: Parameter

861040
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

metaid_0000125
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: mRNAIKB_alpha
type: Species

861268
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

861352
stoichiometry: 1.0
species: metaid_0000104
type: SpeciesReference

metaid_0000076
constant: true
value: 8.0E-13
type: Parameter

860416
stoichiometry: 1.0
species: metaid_0000134
type: SpeciesReference

metaid_0000095
constant: true
value: 0.0061
name: =kf68/kf64
type: Parameter

metaid_0000012
constant: true
value: 0.1
type: Parameter

metaid_0000115
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: sa19_degraded
type: Species

860500
stoichiometry: 1.0
species: metaid_0000135
type: SpeciesReference

metaid_0000167
kinetic law: 861256
product: 861244
product: 861232
reactant: 861220
fast: false
reversible: false
type: Reaction

860596
stoichiometry: 1.0
species: metaid_0000102
type: SpeciesReference

metaid_0000177
kinetic law: 861688
product: 861676
reactant: 861664
reactant: 861652
fast: false
reversible: false
type: Reaction

860212
stoichiometry: 1.0
species: metaid_0000101
type: SpeciesReference

metaid_0000056
constant: true
value: 5.0E-5
type: Parameter

861616
stoichiometry: 5.0
species: metaid_0000131
type: SpeciesReference

metaid_0000077
constant: true
value: 0.62
type: Parameter

metaid_0000150
modifier: 860548
product: 860512
modifier: 860560
modifier: 860536
modifier: 860524
reversible: false
reactant: 860500
type: Reaction
kinetic law: 860572
fast: false

metaid_0000126
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: ActivePRaseonIkB_alpha
type: Species

metaid_0000112
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: A20
type: Species

metaid_0000098
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

metaid_0000013
constant: true
value: 1.25E-4
type: Parameter

metaid_0000087
constant: true
value: 0.0038
type: Parameter

861844
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000164
kinetic law: 861124
product: 861112
reactant: 861100
fast: false
reversible: false
type: Reaction

metaid_0000027
constant: true
value: 0.5
type: Parameter

861004
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000067
constant: true
value: 0.62
type: Parameter

metaid_0000183
kinetic law: 861904
product: 861892
reactant: 861880
fast: false
reversible: false
type: Reaction

860764
stoichiometry: 1.0
species: metaid_0000106
type: SpeciesReference

metaid_0000057
constant: true
value: 6.4E-5
type: Parameter

860176
stoichiometry: 1.0
species: metaid_0000134
type: SpeciesReference

metaid_0000178
kinetic law: 861724
product: 861712
reactant: 861700
fast: false
reversible: false
type: Reaction

metaid_0000078
constant: true
value: 4.8E-4
type: Parameter

metaid_0000151
kinetic law: 860608
product: 860596
reactant: 860584
fast: false
reversible: false
type: Reaction

860428
stoichiometry: 1.0
species: metaid_0000131
type: SpeciesReference

860512
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

metaid_0000014
constant: true
value: 2.0E-5
type: Parameter

metaid_0000127
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: NFkB:IkB_alpha
type: Species

metaid_0000113
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: sa444_degraded
type: Species

metaid_0000181
kinetic law: 861832
product: 861820
reactant: 861808
fast: false
reversible: false
type: Reaction

861592
stoichiometry: 5.0
species: metaid_0000132
type: SpeciesReference

861400
stoichiometry: 1.0
species: metaid_0000116
type: SpeciesReference

metaid_0000097
constant: true
value: 1.0E-10
type: Parameter

861364
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

860908
stoichiometry: 1.0
species: metaid_0000108
type: SpeciesReference

metaid_0000088
constant: true
value: 8.0E-13
type: Parameter

metaid_0000028
constant: true
value: 0.001
type: Parameter

metaid_0000165
kinetic law: 861160
product: 861148
reactant: 861136
fast: false
reversible: false
type: Reaction

860224
stoichiometry: 1.0
species: metaid_0000136
type: SpeciesReference

metaid_0000179
kinetic law: 861760
product: 861748
reactant: 861736
fast: false
reversible: false
type: Reaction

metaid_0000182
kinetic law: 861868
product: 861856
reactant: 861844
fast: false
reversible: false
type: Reaction

metaid_0000068
constant: true
value: 4.8E-4
type: Parameter

861628
stoichiometry: 1.0
species: metaid_0000127
type: SpeciesReference

metaid_0000058
constant: true
value: 10.0
type: Parameter

860284
stoichiometry: 1.0
species: metaid_0000136
type: SpeciesReference

860584
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

860380
stoichiometry: 1.0
species: metaid_0000134
type: SpeciesReference

metaid_0000030
constant: true
value: 0.0
type: Parameter

metaid_0000070
constant: true
value: 0.055
type: Parameter

metaid_0000108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: IkB_alpha
type: Species

metaid_0000159
kinetic law: 860932
product: 860920
product: 860908
reactant: 860896
fast: false
reversible: false
type: Reaction

860368
stoichiometry: 1.0
species: metaid_0000133
type: SpeciesReference

metaid_0000169
kinetic law: 861340
product: 861328
product: 861316
reactant: 861304
fast: false
reversible: false
type: Reaction

metaid_0000040
constant: true
value: 0.006
type: Parameter

metaid_0000048
constant: true
value: 5.0E-5
type: Parameter

860728
stoichiometry: 1.0
species: metaid_0000105
type: SpeciesReference

metaid_0000118
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: sa20_degraded
type: Species

metaid_0000149
kinetic law: 860488
product: 860476
product: 860464
reactant: 860452
fast: false
reversible: false
type: Reaction

861412
stoichiometry: 1.0
species: metaid_0000114
type: SpeciesReference

metaid_0000085
constant: true
value: 0.0038
type: Parameter

861064
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

metaid_0000020
constant: true
value: 8.0E-5
type: Parameter

metaid_0000139
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: PromIkBa:RNAP3:FTAz:p50p65:IkB_alpha
type: Species

861808
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

861376
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

861496
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

metaid_0000010
constant: true
value: 0.1
type: Parameter

metaid_0000128
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: NFkB:IKKa:Ikb_alpha
type: Species

860620
stoichiometry: 1.0
species: metaid_0000141
type: SpeciesReference

860164
stoichiometry: 1.0
species: metaid_0000132
type: SpeciesReference

metaid_0000109
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: sa12_degraded
type: Species

metaid_0000071
constant: true
value: 18.4
type: Parameter

metaid_0000158
kinetic law: 860884
product: 860872
reactant: 860860
fast: false
reversible: false
type: Reaction

metaid_0000184
event assignment: 861941
delay: 861929
trigger: 861917
use values from trigger time: true
name: signal
type: Event

metaid_0000168
kinetic law: 861292
product: 861280
reactant: 861268
fast: false
reversible: false
type: Reaction

860992
stoichiometry: 1.0
species: metaid_0000117
type: SpeciesReference

861316
stoichiometry: 1.0
species: metaid_0000112
type: SpeciesReference

metaid_0000047
constant: true
value: 0.0041
type: Parameter

861784
stoichiometry: 5.0
species: metaid_0000101
type: SpeciesReference

metaid_0000119
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: IKK
type: Species

metaid_0000148
kinetic law: 860440
product: 860428
product: 860416
reactant: 860404
fast: false
reversible: false
type: Reaction

metaid_0000099
constant: true
size: NaN
spatial dimensions: 3.0
name: nucleus
type: Compartment

861856
stoichiometry: 1.0
species: metaid_0000123
type: SpeciesReference

metaid_0000086
constant: true
value: 8.0E-13
type: Parameter

metaid_0000072
constant: true
value: 0.055
type: Parameter

860680
stoichiometry: 1.0
species: metaid_0000104
type: SpeciesReference

metaid_0000138
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: IkBa:RNAP3:FTAz:p50p65
type: Species

860692
stoichiometry: 1.0
species: metaid_0000103
type: SpeciesReference

metaid_0000129
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: NFkB
type: Species

860896
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

metaid_0000157
kinetic law: 860848
product: 860836
reactant: 860824
fast: false
reversible: false
type: Reaction

metaid_0000042
constant: true
value: 5.0E-4
type: Parameter

metaid_0000082
constant: true
value: 0.055
type: Parameter

metaid_0000116
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: IKKa
type: Species

861484
stoichiometry: 1.0
species: metaid_0000108
type: SpeciesReference

metaid_0000083
constant: true
value: 18.4
type: Parameter

metaid_0000022
constant: true
value: 4.0E-4
type: Parameter

861580
stoichiometry: 1.0
species: metaid_0000129
type: SpeciesReference

metaid_0000137
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000099
name: PromIkBa:RNAP3:p50p65:IkBa
type: Species

861076
stoichiometry: 1.0
species: metaid_0000115
type: SpeciesReference

metaid_0000073
constant: true
value: 0.0038
type: Parameter

861304
stoichiometry: 1.0
species: metaid_0000111
type: SpeciesReference

metaid_0000059
constant: true
value: 1.0E-4
type: Parameter

metaid_0000049
constant: true
value: 6.0E-5
type: Parameter

metaid_0000041
constant: true
value: 0.06
type: Parameter

860920
stoichiometry: 1.0
species: metaid_0000125
type: SpeciesReference

861748
stoichiometry: 1.0
species: metaid_0000121
type: SpeciesReference

860788
stoichiometry: 1.0
species: metaid_0000126
type: SpeciesReference

860836
stoichiometry: 1.0
species: metaid_0000109
type: SpeciesReference

861112
stoichiometry: 1.0
species: metaid_0000118
type: SpeciesReference

metaid_0000156
kinetic law: 860812
product: 860800
reactant: 860788
fast: false
reversible: false
type: Reaction

metaid_0000084
constant: true
value: 0.055
type: Parameter

metaid_0000021
constant: true
value: 0.5
type: Parameter

metaid_0000117
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000098
name: IKKn
type: Species

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MODEL7743608569
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notes: NFkB model M(24,45,62) This is a model of NFkB pathway functioning from hierarchy of models of decreasing complexity, created to demonstrate application of model reduction methods proposed in Radulescu O, Gorban A., Zinovyev A., Lilienbaum. A. Robust simplifications of multiscale models in systems biology. Manuscript submitted. The models are provided in CellDesigner v3.5 format. The name of the model M(x,y,z) should be deciphered as following: x - number of species y - number of reactions z - number of parameters Simulation protocol: The model can be simulated in CellDesigner directly, or in any simulator supporting events. The simulation period should be set up in 40 hours (t=144000 sec). The 'signal' event applies signal to the pathway at the moment t=20 hours=72000 sec. For additional information please contact Andrei.Zinovyev at curie.fr This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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metaid_0000019
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product: 860284
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