407362
kinetic law: 830309
product: 830297
reactant: 830285
fast: false
reversible: false
type: Reaction

407562
constant: true
value: 1.0E-4
type: Parameter

407536
constant: true
value: 1.25E-4
type: Parameter

407620
constant: true
value: 0.0053
type: Parameter

407610
constant: true
value: 1.3E-4
type: Parameter

407576
constant: true
value: 0.0
type: Parameter

407248
kinetic law: 829949
product: 829937
product: 829925
reactant: 829913
fast: false
reversible: false
type: Reaction

407642
constant: true
value: 4.8E-4
type: Parameter

407662
constant: true
value: 8.0E-13
type: Parameter

407261
kinetic law: 829997
modifier: 829985
product: 829973
reactant: 829961
fast: false
reversible: false
type: Reaction

407522
constant: true
value: 0.1
type: Parameter

407556
constant: true
value: 3.0E-4
type: Parameter

830465
stoichiometry: 1.0
species: 407159
type: SpeciesReference

407311
kinetic law: 830141
product: 830129
reactant: 830117
fast: false
reversible: false
type: Reaction

407600
constant: true
value: 0.6
type: Parameter

407516
constant: false
value: 0.0
type: Parameter

830213
stoichiometry: 1.0
species: 407149
type: SpeciesReference

407542
constant: true
value: 0.0
type: Parameter

407207
kinetic law: 829829
modifier: 829817
modifier: 829805
product: 829793
reactant: 829781
fast: false
reversible: false
type: Reaction

829973
stoichiometry: 1.0
species: 406956
type: SpeciesReference

407598
constant: true
value: 0.06
type: Parameter

830129
stoichiometry: 1.0
species: 407092
type: SpeciesReference

406956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: mRNAA20
type: Species

407588
constant: true
value: 0.1
type: Parameter

407373
kinetic law: 830357
product: 830345
product: 830333
reactant: 830321
fast: false
reversible: false
type: Reaction

829889
stoichiometry: 1.0
species: 406915
type: SpeciesReference

830777
persistant: true
initial value: true
type: Trigger

407708
constant: true
value: 1.1957E-8
name: =P0*kr58*k62/kf58
type: Parameter

407276
kinetic law: 830033
product: 830021
reactant: 830009
fast: false
reversible: false
type: Reaction

407682
constant: true
value: 8.0E-13
type: Parameter

407322
kinetic law: 830177
product: 830165
reactant: 830153
fast: false
reversible: false
type: Reaction

407630
constant: true
value: 0.025
type: Parameter

407622
constant: true
value: 5.0E-5
type: Parameter

406894
constant: true
size: NaN
spatial dimensions: 3.0
name: nucleus
type: Compartment

407564
constant: true
value: 0.5
type: Parameter

407236
kinetic law: 829901
product: 829889
reactant: 829877
fast: false
reversible: false
type: Reaction

407602
constant: true
value: 0.01
type: Parameter

830501
stoichiometry: 1.0
species: 406925
type: SpeciesReference

407640
constant: true
value: 0.62
type: Parameter

407574
constant: true
value: 0.01
type: Parameter

407524
constant: true
value: 0.0015
type: Parameter

407554
constant: true
value: 4.0E-4
type: Parameter

407073
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: IKKa
type: Species

830453
stoichiometry: 1.0
species: 406925
type: SpeciesReference

830429
stoichiometry: 1.0
species: 407083
type: SpeciesReference

407660
constant: true
value: 0.0038
type: Parameter

407287
kinetic law: 830069
product: 830057
reactant: 830045
fast: false
reversible: false
type: Reaction

830093
stoichiometry: 1.0
species: 407063
type: SpeciesReference

407650
constant: true
value: 0.055
type: Parameter

407544
constant: true
value: 0.5
type: Parameter

407534
constant: true
value: 0.1
type: Parameter

407187
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406894
name: NFkB
type: Species

830153
stoichiometry: 1.0
species: 407168
type: SpeciesReference

407063
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: sa19_degraded
type: Species

407690
constant: true
value: 2.0E-4
type: Parameter

407348
kinetic law: 830273
product: 830261
product: 830249
reactant: 830237
fast: false
reversible: false
type: Reaction

407439
kinetic law: 830573
product: 830561
reactant: 830549
fast: false
reversible: false
type: Reaction

406893
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

407586
constant: true
value: 5.0E-4
type: Parameter

830669
stoichiometry: 1.0
species: 406956
type: SpeciesReference

407680
constant: true
value: 0.0038
type: Parameter

407334
kinetic law: 830225
product: 830213
reactant: 830201
reactant: 830189
fast: false
reversible: false
type: Reaction

406904
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406894
name: IkB_alpha
type: Species

407670
constant: true
value: 4.8E-4
type: Parameter

407299
kinetic law: 830105
product: 830093
reactant: 830081
fast: false
reversible: false
type: Reaction

407526
constant: true
value: 1.25E-4
type: Parameter

830165
stoichiometry: 1.0
species: 407073
type: SpeciesReference

830705
stoichiometry: 1.0
species: 406967
type: SpeciesReference

407566
constant: true
value: 0.001
type: Parameter

830417
stoichiometry: 1.0
species: 407102
type: SpeciesReference

407121
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: sa97_degraded
type: Species

407452
kinetic law: 830609
product: 830597
reactant: 830585
fast: false
reversible: false
type: Reaction

407624
constant: true
value: 6.4E-5
type: Parameter

407652
constant: true
value: 18.4
type: Parameter

830513
stoichiometry: 1.0
species: 407073
type: SpeciesReference

407111
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: sa96_degraded
type: Species

407552
constant: true
value: 0.5
type: Parameter

407666
constant: true
value: 4.8E-4
type: Parameter

407386
kinetic law: 830405
modifier: 830393
product: 830381
reactant: 830369
fast: false
reversible: false
type: Reaction

407614
constant: true
value: 10.0
type: Parameter

407513
event assignment: 830801
delay: 830789
trigger: 830777
use values from trigger time: true
name: signal
type: Event

407692
constant: true
value: 6.66E-6
name: concentration of promoters
type: Parameter

407130
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: mRNAIKB_alpha
type: Species

830261
stoichiometry: 1.0
species: 407073
type: SpeciesReference

830753
stoichiometry: 5.0
species: 406904
type: SpeciesReference

830477
stoichiometry: 1.0
species: 407140
type: SpeciesReference

830369
stoichiometry: 1.0
species: 407073
type: SpeciesReference

407500
kinetic law: 830765
product: 830753
reactant: 830741
fast: false
reversible: false
type: Reaction

407578
constant: true
value: 10.0
type: Parameter

407710
constant: true
value: 0.0061
name: =kf60/kf56
type: Parameter

407528
constant: true
value: 0.24
type: Parameter

407464
kinetic law: 830657
product: 830645
reactant: 830633
reactant: 830621
fast: false
reversible: false
type: Reaction

407612
constant: true
value: 6.4E-5
type: Parameter

830201
stoichiometry: 1.0
species: 407140
type: SpeciesReference

407538
constant: true
value: 2.0E-5
type: Parameter

407568
constant: true
value: 5.0E-4
type: Parameter

407540
constant: true
value: 0.5
type: Parameter

407626
constant: true
value: 10.0
type: Parameter

407654
constant: true
value: 0.055
type: Parameter

830189
stoichiometry: 1.0
species: 407073
type: SpeciesReference

830561
stoichiometry: 5.0
species: 407187
type: SpeciesReference

407426
kinetic law: 830537
product: 830525
reactant: 830513
reactant: 830501
fast: false
reversible: false
type: Reaction

407664
constant: true
value: 0.62
type: Parameter

407550
constant: true
value: 8.0E-5
type: Parameter

830525
stoichiometry: 1.0
species: 407168
type: SpeciesReference

407694
constant: true
value: 7.07E-5
name: =k43*k45*P0 / k46
type: Parameter

829877
stoichiometry: 1.0
species: 406925
type: SpeciesReference

830117
stoichiometry: 1.0
species: 407073
type: SpeciesReference

829961
stoichiometry: 1.0
species: 406946
type: SpeciesReference

407618
constant: true
value: 0.016
type: Parameter

830285
stoichiometry: 1.0
species: 406988
type: SpeciesReference

407712
constant: true
value: 0.003
name: =kr58/kf58
type: Parameter

829853
stoichiometry: 1.0
species: 406936
type: SpeciesReference

830645
stoichiometry: 1.0
species: 407178
type: SpeciesReference

407628
constant: true
value: 1.0E-4
type: Parameter

407702
constant: true
value: 0.003
name: =kr66/kf66
type: Parameter

407608
constant: true
value: 6.0E-5
type: Parameter

407676
constant: true
value: 18.4
type: Parameter

407636
constant: true
value: 2.0E-4
type: Parameter

406925
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: IkB_alpha
type: Species

407656
constant: true
value: 0.0038
type: Parameter

830597
stoichiometry: 1.0
species: 407140
type: SpeciesReference

407580
constant: true
value: 1.0E-4
type: Parameter

830345
stoichiometry: 1.0
species: 406956
type: SpeciesReference

407696
constant: true
value: 2.2925E-7
name: =k36*k39*P0*k34*kf68/(k37*kf64*(k38+k39))
type: Parameter

407590
constant: true
value: 0.006
type: Parameter

830717
stoichiometry: 1.0
species: 407121
type: SpeciesReference

830741
stoichiometry: 1.0
species: 406925
type: SpeciesReference

407616
constant: true
value: 1.0E-4
type: Parameter

830009
stoichiometry: 1.0
species: 407083
type: SpeciesReference

407714
constant: true
value: 1.0E-10
name: dummy
type: Parameter

829841
stoichiometry: 1.0
species: 407130
type: SpeciesReference

407083
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: IKKn
type: Species

407140
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.166
in compartment: 406893
name: NFkB:IkB_alpha
type: Species

407700
constant: true
value: 0.0061
name: =kf68/kf64
type: Parameter

407401
kinetic law: 830441
product: 830429
reactant: 830417
fast: false
reversible: false
type: Reaction

407648
constant: true
value: 18.4
type: Parameter

407678
constant: true
value: 0.055
type: Parameter

407688
constant: true
value: 2.0E-4
type: Parameter

407102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406894
name: IKK
type: Species

407638
constant: true
value: 2.0E-4
type: Parameter

407658
constant: true
value: 8.0E-13
type: Parameter

829913
stoichiometry: 1.0
species: 407130
type: SpeciesReference

830021
stoichiometry: 1.0
species: 407073
type: SpeciesReference

407412
kinetic law: 830489
product: 830477
reactant: 830465
reactant: 830453
fast: false
reversible: false
type: Reaction

830585
stoichiometry: 5.0
species: 407178
type: SpeciesReference

407668
constant: true
value: 0.62
type: Parameter

407592
constant: true
value: 0.06
type: Parameter

407698
constant: true
value: 6.7E-8
name: =k39*k36*kr66*k70*P0/(k37*kf66*(k38+k39))
type: Parameter

829781
stoichiometry: 1.0
species: 407198
type: SpeciesReference

407706
constant: true
value: 8.172E-10
name: =P0*k50*k60/k56
type: Parameter

MODEL7743444866
area units: area
parameter: 407528
curated: false
parameter: 407682
species: 407187
reaction: 407386
parameter: 407678
parameter: 407530
parameter: 407516
parameter: 407564
reaction: 407426
parameter: 407712
parameter: 407580
parameter: 407552
species: 406925
parameter: 407634
species: 407092
reaction: 407276
species: 407063
parameter: 407670
species: 406978
parameter: 407586
compartment: 406894
parameter: 407624
parameter: 407654
species: 406988
parameter: 407700
reaction: 407362
parameter: 407526
species: 407178
parameter: 407578
parameter: 407608
parameter: 407642
species: 407102
parameter: 407676
parameter: 407562
parameter: 407548
length unit: length
parameter: 407706
reaction: 407373
parameter: 407534
parameter: 407612
reaction: 407401
parameter: 407550
parameter: 407632
reaction: 407439
species: 406915
parameter: 407570
parameter: 407600
notes: NFkB model M(14,25,33) This is a model of NFkB pathway functioning from hierarchy of models of decreasing complexity, created to demonstrate application of model reduction methods Radulescu O, Gorban A., Zinovyev A., Lilienbaum. A. Robust simplifications of multiscale models in The models are provided in CellDesigner v3.5 format. The name of the model M(x,y,z) should be x - number of species y - number of reactions Simulation protocol: The model can be simulated in CellDesigner directly, or in any simulator supporting events. The simulation period should be set up in 40 hours (t=144000 sec). The 'signal' event applies signal to the For additional information please contact This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: 407322
parameter: 407584
parameter: 407618
parameter: 407652
species: 407073
parameter: 407638
species: 407140
species: 407083
parameter: 407576
parameter: 407606
parameter: 407640
parameter: 407674
reaction: 407225
parameter: 407592
reaction: 407348
parameter: 407704
parameter: 407610
species: 407130
parameter: 407544
parameter: 407668
reaction: 407236
parameter: 407598
parameter: 407666
time units: 754168
parameter: 407538
reaction: 407287
parameter: 407616
parameter: 407650
species: 407149
parameter: 407636

407198
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406894
name: IKB_alpha
type: Species

407572
constant: true
value: 4.0E-4
type: Parameter

830621
stoichiometry: 1.0
species: 407187
type: SpeciesReference

407604
constant: true
value: 0.0041
type: Parameter

830681
stoichiometry: 1.0
species: 407111
type: SpeciesReference

830249
stoichiometry: 1.0
species: 407159
type: SpeciesReference

407532
constant: true
value: 1.2
type: Parameter

407546
constant: true
value: 0.0
type: Parameter

830321
stoichiometry: 1.0
species: 406956
type: SpeciesReference

829793
stoichiometry: 1.0
species: 407130
type: SpeciesReference

830549
stoichiometry: 1.0
species: 407159
type: SpeciesReference

407686
constant: true
value: 8.0E-13
type: Parameter

406915
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: sa13_degraded
type: Species

830081
stoichiometry: 1.0
species: 407083
type: SpeciesReference

407646
constant: true
value: 4.8E-4
type: Parameter

407672
constant: true
value: 18.4
type: Parameter

407489
kinetic law: 830729
product: 830717
reactant: 830705
fast: false
reversible: false
type: Reaction

829925
stoichiometry: 1.0
species: 406925
type: SpeciesReference

407092
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: sa20_degraded
type: Species

407584
constant: true
value: 0.1
type: Parameter

406967
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: A20
type: Species

407594
constant: true
value: 5.0E-4
type: Parameter

407632
constant: true
value: 0.003
type: Parameter

407704
constant: true
value: 1.0E-10
name: dummy
type: Parameter

407178
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406894
name: NFkB:IkB_alpha
type: Species

407478
kinetic law: 830693
product: 830681
reactant: 830669
fast: false
reversible: false
type: Reaction

407518
constant: true
value: 1.25E-4
type: Parameter

406988
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: IKKi
type: Species

830057
stoichiometry: 1.0
species: 407159
type: SpeciesReference

407168
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: IKKa:IKB_alpha
type: Species

406978
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: sa444_degraded
type: Species

407560
constant: true
value: 0.0
type: Parameter

830381
stoichiometry: 1.0
species: 406988
type: SpeciesReference

406936
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: sa12_degraded
type: Species

407606
constant: true
value: 5.0E-5
type: Parameter

407570
constant: true
value: 0.0
type: Parameter

830297
stoichiometry: 1.0
species: 406978
type: SpeciesReference

407225
kinetic law: 829865
product: 829853
reactant: 829841
fast: false
reversible: false
type: Reaction

406946
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406894
name: A20
type: Species

830633
stoichiometry: 1.0
species: 406904
type: SpeciesReference

407684
constant: true
value: 0.0038
type: Parameter

407530
constant: true
value: 0.1
type: Parameter

830045
stoichiometry: 1.0
species: 407140
type: SpeciesReference

407674
constant: true
value: 0.055
type: Parameter

830237
stoichiometry: 1.0
species: 407149
type: SpeciesReference

407520
constant: true
value: 1.0E-5
type: Parameter

830333
stoichiometry: 1.0
species: 406967
type: SpeciesReference

407149
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: NFkB:IKKa:Ikb_alpha
type: Species

407558
constant: true
value: 5.0E-7
type: Parameter

407644
constant: true
value: 0.62
type: Parameter

829937
stoichiometry: 1.0
species: 407130
type: SpeciesReference

407634
constant: true
value: 0.001
type: Parameter

407582
constant: true
value: 5.0E-4
type: Parameter

407548
constant: true
value: 0.0025
type: Parameter

407159
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 406893
name: NFkB
type: Species

407596
constant: true
value: 0.02
type: Parameter