554675
constant: true
value: 0.015
name: =k5/k4
type: Parameter

821077
stoichiometry: 1.0
species: 554306
type: SpeciesReference

554655
constant: true
value: 5.0E-4
type: Parameter

821425
stoichiometry: 1.0
species: 554406
type: SpeciesReference

820993
stoichiometry: 1.0
species: 554326
type: SpeciesReference

554645
constant: true
value: 5.0E-7
type: Parameter

554502
kinetic law: 821209
modifier: 821197
product: 821185
reactant: 821173
fast: false
reversible: false
type: Reaction

554625
constant: true
value: 2.0E-5
type: Parameter

821269
stoichiometry: 5.0
species: 554396
type: SpeciesReference

554635
constant: true
value: 0.0025
type: Parameter

821221
stoichiometry: 1.0
species: 554346
type: SpeciesReference

554287
constant: true
size: NaN
spatial dimensions: 3.0
name: nucleus
type: Compartment

554605
constant: true
value: 1.25E-4
type: Parameter

554296
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boundary condition: true
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initial concentration: NaN
initial amount: 0.0
in compartment: 554287
name: IKBA
type: Species

554529
kinetic law: 821293
product: 821281
reactant: 821269
fast: false
reversible: false
type: Reaction

554615
constant: true
value: 0.2
type: Parameter

821365
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species: 554376
type: SpeciesReference

554575
kinetic law: 821449
product: 821437
reactant: 821425
fast: false
reversible: false
type: Reaction

554306
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 554285
name: sa13_degraded
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821137
stoichiometry: 1.0
species: 554406
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821437
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species: 554427
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554657
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value: 4.0E-4
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554416
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name: NFKB
type: Species

554355
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boundary condition: false
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initial concentration: NaN
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554406
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
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554643
constant: true
value: 3.0E-4
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554637
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554623
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value: 1.25E-4
type: Parameter

821173
stoichiometry: 1.0
species: 554336
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554564
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product: 821401
reactant: 821389
fast: false
reversible: false
type: Reaction

821029
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species: 554326
type: SpeciesReference

554450
kinetic law: 821053
product: 821041
reactant: 821029
fast: false
reversible: false
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554553
kinetic law: 821377
product: 821365
reactant: 821353
fast: false
reversible: false
type: Reaction

821233
stoichiometry: 1.0
species: 554355
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554489
kinetic law: 821161
product: 821149
product: 821137
reactant: 821125
fast: false
reversible: false
type: Reaction

821185
stoichiometry: 1.0
species: 554346
type: SpeciesReference

554346
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 554285
name: mRNAA20
type: Species

554661
constant: true
value: 0.0
type: Parameter

821305
stoichiometry: 1.0
species: 554416
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554641
constant: true
value: 4.0E-4
type: Parameter

554437
kinetic law: 821017
modifier: 821005
product: 820993
reactant: 820981
fast: false
reversible: false
type: Reaction

821353
stoichiometry: 1.0
species: 554346
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821149
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species: 554326
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554336
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 554287
name: A20
type: Species

554326
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 554285
name: mRNAIKBA
type: Species

554617
constant: true
value: 0.1
type: Parameter

554603
constant: true
value: 0.0025
type: Parameter

554427
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 554287
name: IkB_alpha
type: Species

554316
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 554285
name: sa12_degraded
type: Species

554516
kinetic law: 821257
product: 821245
product: 821233
reactant: 821221
fast: false
reversible: false
type: Reaction

554629
constant: true
value: 0.0
type: Parameter

554366
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.166
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name: NFKB.IKBA
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554386
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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 554285
name: sa97_degraded
type: Species

554659
constant: true
value: 0.01
type: Parameter

554396
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 554287
name: NFkB/IkB_alpha
type: Species

554649
constant: true
value: 1.0E-4
type: Parameter

554376
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 554285
name: sa96_degraded
type: Species

554639
constant: true
value: 0.5
type: Parameter

554631
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value: 18.4
type: Parameter

554671
constant: true
value: 2.0E-5
name: =k3*k9/k4
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821317
stoichiometry: 1.0
species: 554427
type: SpeciesReference

554621
constant: true
value: 0.1
type: Parameter

821401
stoichiometry: 1.0
species: 554386
type: SpeciesReference

554586
kinetic law: 821509
modifier: 821497
modifier: 821485
product: 821473
reactant: 821461
fast: false
reversible: false
type: Reaction

554611
constant: true
value: 0.0015
type: Parameter

821461
stoichiometry: 1.0
species: 554366
type: SpeciesReference

821389
stoichiometry: 1.0
species: 554355
type: SpeciesReference

MODEL7743358405
is described by: http://identifiers.org/pubmed/18854041
parameter: 554627
parameter: 554613
curated: false
parameter: 554657
reaction: 554516
species: 554346
parameter: 554653
species: 554386
species: 554427
species: 554406
parameter: 554609
parameter: 554633
parameter: 554661
parameter: 554619
parameter: 554669
parameter: 554637
area units: area
length unit: length
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species: 554396
reaction: 554502
reaction: 554553
parameter: 554647
species: 554416
species: 554366
parameter: 554629
parameter: 554639
species: 554316
species: 554306
parameter: 554623
reaction: 554564
reaction: 554489
species: 554376
parameter: 554605
parameter: 554615
parameter: 554663
volume units: metaid_0000217
parameter: 554643
reaction: 554474
substance units: 106194
species: 554355
reaction: 554437
compartment: 554285
compartment: 554287
reaction: 554450
time units: 754168
species: 554296
parameter: 554625
parameter: 554635
parameter: 554671
reaction: 554575
parameter: 554617
reaction: 554540
parameter: 554665
parameter: 554673
reaction: 554586
parameter: 554611
parameter: 554645
parameter: 554655
species: 554326
parameter: 554649
parameter: 554659
parameter: 554641
parameter: 554651
type: SBMLModel
parameter: 554603
parameter: 554621
parameter: 554631
parameter: 554607
reaction: 554529
parameter: 554667
species: 554336
notes: NFkB model M(8,12,19) This is a model of NFkB pathway functioning from hierarchy of models of decreasing complexity, created to demonstrate application of model reduction methods proposed in Radulescu O, Gorban A., Zinovyev A., Lilienbaum. A. Robust simplifications of multiscale models in systems biology. Manuscript submitted. The models are provided in CellDesigner v3.5 format. The name of the model M(x,y,z) should be deciphered as following: x - number of species y - number of reactions z - number of parameters Simulation protocol: The model can be simulated in CellDesigner directly, or in any simulator supporting events. The simulation period should be set up in 40 hours (t=144000 sec). The 'signal' event applies signal to the pathway at the moment t=20 hours=72000 sec. For additional information please contact Andrei.Zinovyev at curie.fr This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
name: Radulescu2008_NFkB_hierarchy_M_8_12_19

554619
constant: true
value: 1.0
type: Parameter

554653
constant: true
value: 0.001
type: Parameter

821041
stoichiometry: 1.0
species: 554316
type: SpeciesReference

554667
constant: true
value: 1.359E-4
name: =kf15/kf13
type: Parameter

554663
constant: true
value: 5.0E-7
type: Parameter

821245
stoichiometry: 1.0
species: 554346
type: SpeciesReference

554609
constant: true
value: 0.1
type: Parameter

554647
constant: true
value: 0.0
type: Parameter

554627
constant: true
value: 18.4
type: Parameter

554474
kinetic law: 821113
modifier: 821101
modifier: 821089
product: 821077
reactant: 821065
fast: false
reversible: false
type: Reaction

554285
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

554673
constant: true
value: 1.359E-4
name: =kf15/kf13
type: Parameter

554633
constant: true
value: 0.0
type: Parameter

554540
kinetic law: 821341
product: 821329
reactant: 821317
reactant: 821305
fast: false
reversible: false
type: Reaction

821125
stoichiometry: 1.0
species: 554326
type: SpeciesReference

821065
stoichiometry: 1.0
species: 554406
type: SpeciesReference

821329
stoichiometry: 1.0
species: 554396
type: SpeciesReference

821473
stoichiometry: 5.0
species: 554416
type: SpeciesReference

821281
stoichiometry: 1.0
species: 554366
type: SpeciesReference

554613
constant: true
value: 1.25E-4
type: Parameter

554651
constant: true
value: 0.5
type: Parameter

820981
stoichiometry: 1.0
species: 554296
type: SpeciesReference

554607
constant: false
value: 2.5E-6
type: Parameter

554665
constant: true
value: 3.397E-9
name: =kf15*k3*k9/k4/kf13
type: Parameter

554669
constant: true
value: 0.015
name: =k5/k4
type: Parameter