509091
constant: true
value: 5.0
name: cytoplasm/nucleus volume ratio
type: Parameter

509081
constant: true
value: 1.359E-4
name: =kf15/kf13
type: Parameter

811973
stoichiometry: 1.0
species: 508803
type: SpeciesReference

509061
constant: true
value: 0.0
type: Parameter

508772
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508752
name: sa13_degraded
type: Species

509021
constant: false
value: 2.5E-6
type: Parameter

508753
constant: true
size: NaN
spatial dimensions: 3.0
name: nucleus
type: Compartment

509071
constant: true
value: 4.0E-4
type: Parameter

811829
stoichiometry: 1.0
species: 508792
type: SpeciesReference

509089
constant: true
value: 0.015
name: =k5/k4
type: Parameter

509027
constant: true
value: 1.25E-4
type: Parameter

508813
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508752
name: mRNAA20
type: Species

509031
constant: true
value: 0.1
type: Parameter

508792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508752
name: mRNAIKBA
type: Species

MODEL7743315447
parameter: 509049
species: 508762
parameter: 509045
parameter: 509085
species: 508813
reaction: 508910
parameter: 509037
parameter: 509029
parameter: 509069
parameter: 509091
parameter: 509053
length unit: length
compartment: 508752
parameter: 509041
parameter: 509033
parameter: 509073
is described by: http://identifiers.org/pubmed/18854041
species: 508864
parameter: 509025
reaction: 508974
parameter: 509021
parameter: 509061
parameter: 509089
parameter: 509016
curated: false
reaction: 508938
time units: 754168
parameter: 509039
parameter: 509093
species: 508834
parameter: 509077
parameter: 509081
reaction: 508985
parameter: 509065
parameter: 509027
reaction: 508898
name: Radulescu2008_NFkB_hierarchy_M_6_10_15
species: 508782
species: 508803
parameter: 509031
reaction: 508925
parameter: 509055
parameter: 509095
substance units: 106194
area units: area
volume units: metaid_0000217
parameter: 509047
parameter: 509079
notes: NFkB model M(6,10,15) This is a model of NFkB pathway functioning from hierarchy of models of decreasing complexity, created to demonstrate application of model reduction methods proposed in Radulescu O, Gorban A., Zinovyev A., Lilienbaum. A. Robust simplifications of multiscale models in systems biology. Manuscript submitted. The models are provided in CellDesigner v3.5 format. The name of the model M(x,y,z) should be deciphered as following: x - number of species y - number of reactions z - number of parameters Simulation protocol: The model can be simulated in CellDesigner directly, or in any simulator supporting events. The simulation period should be set up in 40 hours (t=144000 sec). The 'signal' event applies signal to the pathway at the moment t=20 hours=72000 sec. For additional information please contact Andrei.Zinovyev at curie.fr This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
parameter: 509043
parameter: 509083
parameter: 509035
parameter: 509067
reaction: 508885
species: 508854
parameter: 509019
parameter: 509059
species: 508823
species: 508844
type: SBMLModel
reaction: 509002
parameter: 509051
species: 508792
species: 508772
compartment: 508753
parameter: 509075
parameter: 509071
reaction: 508951
species: 508875
parameter: 509023
parameter: 509063
parameter: 509087
reaction: 508963
parameter: 509057

811985
stoichiometry: 1.0
species: 508813
type: SpeciesReference

508885
kinetic law: 811817
modifier: 811805
product: 811793
reactant: 811781
fast: false
reversible: false
type: Reaction

508925
kinetic law: 811961
product: 811949
product: 811937
reactant: 811925
fast: false
reversible: false
type: Reaction

508823
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508752
name: A20
type: Species

812153
stoichiometry: 5.0
species: 508875
type: SpeciesReference

812105
stoichiometry: 1.0
species: 508823
type: SpeciesReference

508854
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508752
name: sa97_degraded
type: Species

509051
constant: true
value: 0.0
type: Parameter

509037
constant: true
value: 1.25E-4
type: Parameter

508844
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508752
name: sa96_degraded
type: Species

509079
constant: true
value: 3.397E-9
name: =kf15*k3*k9/k4/kf13
type: Parameter

811841
stoichiometry: 1.0
species: 508782
type: SpeciesReference

812201
stoichiometry: 5.0
species: 508875
type: SpeciesReference

508752
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

508834
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.06
in compartment: 508752
name: NFKB.IKBA
type: Species

509069
constant: true
value: 5.0E-4
type: Parameter

509041
constant: true
value: 18.4
type: Parameter

509047
constant: true
value: 0.0
type: Parameter

508864
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508752
name: IkB_alpha
type: Species

509093
constant: true
value: 0.001
name: =kf23
type: Parameter

811865
stoichiometry: 1.0
species: 508864
type: SpeciesReference

509016
constant: true
value: 0.0025
type: Parameter

509033
constant: true
value: 1.0
type: Parameter

812081
stoichiometry: 1.0
species: 508844
type: SpeciesReference

812045
stoichiometry: 1.0
species: 508813
type: SpeciesReference

509073
constant: true
value: 0.01
type: Parameter

508951
kinetic law: 812057
product: 812045
product: 812033
reactant: 812021
fast: false
reversible: false
type: Reaction

509087
constant: true
value: 1.359E-4
name: =kf15/kf13
type: Parameter

509029
constant: true
value: 0.2
type: Parameter

509035
constant: true
value: 0.1
type: Parameter

811793
stoichiometry: 1.0
species: 508792
type: SpeciesReference

812213
stoichiometry: 1.0
species: 508864
type: SpeciesReference

509053
constant: true
value: 0.5
type: Parameter

509049
constant: true
value: 0.0025
type: Parameter

509067
constant: true
value: 0.001
type: Parameter

508985
kinetic law: 812189
modifier: 812177
modifier: 812165
product: 812153
reactant: 812141
fast: false
reversible: false
type: Reaction

811949
stoichiometry: 1.0
species: 508792
type: SpeciesReference

509075
constant: true
value: 0.0
type: Parameter

509055
constant: true
value: 4.0E-4
type: Parameter

509085
constant: true
value: 2.0E-5
name: =k3*k9/k4
type: Parameter

811937
stoichiometry: 1.0
species: 508864
type: SpeciesReference

508910
kinetic law: 811913
modifier: 811901
modifier: 811889
product: 811877
reactant: 811865
fast: false
reversible: false
type: Reaction

509095
constant: true
value: 1.359E-4
name: =kv*kr23/kf14
type: Parameter

812225
stoichiometry: 1.0
species: 508834
type: SpeciesReference

509045
constant: true
value: 18.4
type: Parameter

508938
kinetic law: 812009
modifier: 811997
product: 811985
reactant: 811973
fast: false
reversible: false
type: Reaction

811877
stoichiometry: 1.0
species: 508772
type: SpeciesReference

812033
stoichiometry: 1.0
species: 508823
type: SpeciesReference

508762
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508753
name: IKBA
type: Species

811781
stoichiometry: 1.0
species: 508762
type: SpeciesReference

508875
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508753
name: NFKB
type: Species

509023
constant: true
value: 0.1
type: Parameter

508963
kinetic law: 812093
product: 812081
reactant: 812069
fast: false
reversible: false
type: Reaction

508782
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508752
name: sa12_degraded
type: Species

509065
constant: true
value: 0.5
type: Parameter

509002
kinetic law: 812237
product: 812225
reactant: 812213
reactant: 812201
fast: false
reversible: false
type: Reaction

508974
kinetic law: 812129
product: 812117
reactant: 812105
fast: false
reversible: false
type: Reaction

509083
constant: true
value: 0.015
name: =k5/k4
type: Parameter

509057
constant: true
value: 3.0E-4
type: Parameter

812069
stoichiometry: 1.0
species: 508813
type: SpeciesReference

509059
constant: true
value: 5.0E-7
type: Parameter

811925
stoichiometry: 1.0
species: 508792
type: SpeciesReference

509063
constant: true
value: 1.0E-4
type: Parameter

509043
constant: true
value: 0.0
type: Parameter

508898
kinetic law: 811853
product: 811841
reactant: 811829
fast: false
reversible: false
type: Reaction

508803
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 508753
name: A20
type: Species

812117
stoichiometry: 1.0
species: 508854
type: SpeciesReference

812021
stoichiometry: 1.0
species: 508813
type: SpeciesReference

509025
constant: true
value: 0.0015
type: Parameter

812141
stoichiometry: 1.0
species: 508834
type: SpeciesReference

509077
constant: true
value: 5.0E-7
type: Parameter

509019
constant: true
value: 1.25E-4
type: Parameter

509039
constant: true
value: 2.0E-5
type: Parameter