494309
kinetic law: 803869
modifier: 803857
product: 803845
reactant: 803833
fast: false
reversible: false
type: Reaction

803725
stoichiometry: 1.0
species: 494236
type: SpeciesReference

494195
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 494147
name: A20
type: Species

494216
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.06
in compartment: 494145
name: NFKB.IKBA
type: Species

494166
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 494145
name: sa13_degraded
type: Species

494413
constant: true
value: 0.001
type: Parameter

803641
stoichiometry: 1.0
species: 494156
type: SpeciesReference

803893
stoichiometry: 1.0
species: 494226
type: SpeciesReference

494281
kinetic law: 803773
modifier: 803761
modifier: 803749
product: 803737
reactant: 803725
fast: false
reversible: false
type: Reaction

494147
constant: true
size: NaN
spatial dimensions: 3.0
name: nucleus
type: Compartment

803797
stoichiometry: 1.0
species: 494236
type: SpeciesReference

494156
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 494147
name: IKBA
type: Species

494365
constant: true
value: 1.25E-4
type: Parameter

494226
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 494145
name: sa97_degraded
type: Species

494417
constant: true
value: 4.0E-4
type: Parameter

494403
constant: true
value: 3.0E-4
type: Parameter

494176
constant: true
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 494145
name: sa12_degraded
type: Species

494246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 494147
name: NFKB
type: Species

494236
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 494145
name: IkB_alpha
type: Species

494369
constant: true
value: 0.1
type: Parameter

494379
constant: true
value: 1.0
type: Parameter

494391
constant: true
value: 18.4
type: Parameter

494375
constant: true
value: 0.2
type: Parameter

494385
constant: true
value: 2.0E-5
type: Parameter

494427
constant: true
value: 1.359E-4
name: =kf15/kf13
type: Parameter

494389
constant: true
value: 0.0
type: Parameter

494395
constant: true
value: 0.0025
type: Parameter

494407
constant: true
value: 0.0
type: Parameter

494443
constant: true
value: 6.25E-4
name: =k16*k20/k17
type: Parameter

494433
constant: true
value: 1.359E-4
name: =kf15/kf13
type: Parameter

494423
constant: true
value: 5.0E-7
type: Parameter

494257
kinetic law: 803677
modifier: 803665
product: 803653
reactant: 803641
fast: false
reversible: false
type: Reaction

803785
stoichiometry: 1.0
species: 494185
type: SpeciesReference

494381
constant: true
value: 0.1
type: Parameter

803989
stoichiometry: 1.0
species: 494236
type: SpeciesReference

494371
constant: true
value: 0.0015
type: Parameter

494185
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 494145
name: mRNAIKBA
type: Species

494399
constant: true
value: 0.5
type: Parameter

803917
stoichiometry: 1.0
species: 494216
type: SpeciesReference

494437
constant: true
value: 5.0
name: cytoplasm/nucleus volume ratio
type: Parameter

494401
constant: true
value: 4.0E-4
type: Parameter

803653
stoichiometry: 1.0
species: 494185
type: SpeciesReference

803881
stoichiometry: 1.0
species: 494205
type: SpeciesReference

803929
stoichiometry: 5.0
species: 494246
type: SpeciesReference

804001
stoichiometry: 1.0
species: 494216
type: SpeciesReference

MODEL7743212613
parameter: 494399
parameter: 494381
parameter: 494443
reaction: 494309
length unit: length
parameter: 494441
parameter: 494419
volume units: metaid_0000217
parameter: 494387
parameter: 494431
time units: 754168
parameter: 494407
parameter: 494363
parameter: 494375
species: 494185
parameter: 494435
species: 494226
parameter: 494367
parameter: 494379
species: 494205
parameter: 494411
parameter: 494423
parameter: 494437
parameter: 494393
parameter: 494425
parameter: 494417
reaction: 494350
name: Radulescu2008_NFkB_hierarchy_M_5_8_12
parameter: 494405
compartment: 494147
species: 494176
parameter: 494395
reaction: 494281
parameter: 494429
parameter: 494385
reaction: 494333
reaction: 494296
parameter: 494389
parameter: 494373
parameter: 494433
parameter: 494377
parameter: 494369
parameter: 494421
species: 494236
parameter: 494439
species: 494246
parameter: 494391
reaction: 494322
parameter: 494415
parameter: 494427
species: 494195
reaction: 494257
reaction: 494270
parameter: 494403
parameter: 494397
substance units: 106194
notes: NFkB model M(5,8,12) - minimal model This is a model of NFkB pathway functioning from hierarchy of models of decreasing complexity, created to demonstrate application of model reduction methods Radulescu O, Gorban A., Zinovyev A., Lilienbaum. A. Robust simplifications of multiscale models in The models are provided in CellDesigner v3.5 format. The name of the model M(x,y,z) should be deciphered as following x - number of species y - number of reactions Simulation protocol: The model can be simulated in CellDesigner directly, or in any simulator supporting events. The simulation period should be set up in 40 hours (t=144000 sec). The 'signal' event applies signal to the For additional information please contact Andrei.Zinovyev at curie.fr This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
type: SBMLModel
parameter: 494383
curated: false
species: 494156
area units: area
parameter: 494371
compartment: 494145
parameter: 494409
parameter: 494365
species: 494216
species: 494166
parameter: 494413
is described by: http://identifiers.org/pubmed/18854041
parameter: 494401

494145
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

494411
constant: true
value: 0.5
type: Parameter

494270
kinetic law: 803713
product: 803701
reactant: 803689
fast: false
reversible: false
type: Reaction

494415
constant: true
value: 5.0E-4
type: Parameter

494429
constant: true
value: 0.015
name: =k5/k4
type: Parameter

803833
stoichiometry: 1.0
species: 494195
type: SpeciesReference

494367
constant: false
value: 2.5E-6
type: Parameter

494441
constant: true
value: 1.359E-4
name: =kv*kr23/kf14
type: Parameter

494322
kinetic law: 803905
product: 803893
reactant: 803881
fast: false
reversible: false
type: Reaction

494363
constant: true
value: 0.0025
type: Parameter

803737
stoichiometry: 1.0
species: 494166
type: SpeciesReference

494405
constant: true
value: 5.0E-7
type: Parameter

494373
constant: true
value: 1.25E-4
type: Parameter

803845
stoichiometry: 1.0
species: 494205
type: SpeciesReference

494439
constant: true
value: 0.001
name: =kf23
type: Parameter

803809
stoichiometry: 1.0
species: 494185
type: SpeciesReference

494377
constant: true
value: 0.1
type: Parameter

494419
constant: true
value: 0.01
type: Parameter

494409
constant: true
value: 1.0E-4
type: Parameter

494296
kinetic law: 803821
product: 803809
product: 803797
reactant: 803785
fast: false
reversible: false
type: Reaction

494393
constant: true
value: 0.0
type: Parameter

494387
constant: true
value: 18.4
type: Parameter

803701
stoichiometry: 1.0
species: 494176
type: SpeciesReference

494205
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 494145
name: A20
type: Species

803977
stoichiometry: 5.0
species: 494246
type: SpeciesReference

494383
constant: true
value: 1.25E-4
type: Parameter

494397
constant: true
value: 0.0
type: Parameter

494350
kinetic law: 804013
product: 804001
reactant: 803989
reactant: 803977
fast: false
reversible: false
type: Reaction

803689
stoichiometry: 1.0
species: 494185
type: SpeciesReference

494425
constant: true
value: 3.397E-9
name: =kf15*k3*k9/k4/kf13
type: Parameter

494431
constant: true
value: 2.0E-5
name: =k3*k9/k4
type: Parameter

494333
kinetic law: 803965
modifier: 803953
modifier: 803941
product: 803929
reactant: 803917
fast: false
reversible: false
type: Reaction

494421
constant: true
value: 0.0
type: Parameter

494435
constant: true
value: 0.015
name: =k5/k4
type: Parameter