107002
units: 106350
value: 0.3
type: LocalParameter

110031
stoichiometry: 1.0
species: metaid O2
type: SpeciesReference

107086
stoichiometry: 2.0
species: metaid mCO2
type: SpeciesReference

107691
type: Reaction
name: oxidation of FADH2
reversible: true
kinetic law: 107763
reactant: 107703
product: 107751
reactant: 107715
is: SBO:0000176
product: 107739
fast: false
reactant: 107727

107363
units: 106350
value: 27.2727272727273
type: LocalParameter

107739
stoichiometry: 2.0
species: metaid mFAD
type: SpeciesReference

110115
units: 106314
value: 0.14712903673276
type: LocalParameter

108972
stoichiometry: 1.0
species: metaid eL
type: SpeciesReference

metaid NAD
type: Species
is: CHEBI:15846
in compartment: metaid Vol exm
initial concentration: 0.2970297029703
name: NAD
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

109921
units: dimensionless
value: 0.21739130434783
type: LocalParameter

109644
units: 106314
value: 1.73434285714286
type: LocalParameter

106641
exponent: -1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

108354
fast: false
reactant: 108366
is: SBO:0000176
reversible: true
name: PCr to ATP interconversion
reactant: 108379
reactant: 108391
product: 108403
type: Reaction
product: 108416
kinetic law: 108428

108246
units: 106350
value: 1.7022760764E-4
type: LocalParameter

109165
stoichiometry: 1.0
species: metaid mNAD
type: SpeciesReference

110199
stoichiometry: 1.0
species: metaid eAd
type: SpeciesReference

109382
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

107812
units: 106471
value: 0.041429115
type: LocalParameter

106242
exponent: -2.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

110019
stoichiometry: 1.0
species: metaid eO2
type: SpeciesReference

107751
stoichiometry: 16.0
species: metaid Hy
type: SpeciesReference

106954
stoichiometry: 2.0
species: metaid ATP
type: SpeciesReference

109129
reactant: 109153
product: 109190
is: SBO:0000185
product: 109178
reactant: 109165
reactant: 109141
product: 109202
kinetic law: 109214
type: Reaction
reversible: true
name: malate-aspartate shuttle
fast: false

106580
unit: 106616
unit: 106604
unit: 106592
name: per millimolar squared per second
type: SBMLUnitsDef

107351
units: 106350
value: 0.08267716535433
type: LocalParameter

107074
stoichiometry: 1.0
species: metaid AKG
type: SpeciesReference

109104
units: 106653
value: 0.05882600137155
type: LocalParameter

108306
units: 106435
value: 3.4E-5
type: LocalParameter

metaid mCO2
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 2.4624
in compartment: metaid Vol inm
boundary condition: false
constant: false
is: SBO:0000247
name: carbon dioxide
is: CHEBI:16526

107014
units: 106350
value: 0.05
type: LocalParameter

109492
stoichiometry: 1.0
species: metaid mATP
type: SpeciesReference

109178
stoichiometry: 1.0
species: metaid mNADH
type: SpeciesReference

109656
kinetic law: 109692
product: 109680
reactant: 109668
is: SBO:0000185
fast: false
reversible: true
name: CO2 diffusion
type: Reaction

107171
units: 106350
value: 6.4E-4
type: LocalParameter

110296
units: 106314
value: 0.00110055857788
type: LocalParameter

109202
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

108984
stoichiometry: 1.0
species: metaid eL0
type: SpeciesReference

109394
stoichiometry: 1.0
species: metaid mPhos
type: SpeciesReference

106302
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

108706
kinetic law: 108754
product: 108742
product: 108730
reactant: 108718
is: SBO:0000176
fast: false
reversible: true
name: lactic acid dissociation
type: Reaction

108366
stoichiometry: 1.0
species: metaid PCr
type: SpeciesReference

106653
unit: 106665
name: per second
type: SBMLUnitsDef

108258
units: 106350
value: 2.0
type: LocalParameter

109117
units: 106531
value: 74.4632928753754
type: LocalParameter

110308
kinetic law: 110344
product: 110332
reactant: 110320
is: SBO:0000185
fast: false
reversible: true
name: sodium diffusion
type: Reaction

106254
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

107800
units: 106350
value: 0.0011375
type: LocalParameter

106290
exponent: 3.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid Vol exm
is: GO:0005737
constant: true
size: 0.72
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

108318
units: 106350
value: 0.034
type: LocalParameter

109861
stoichiometry: 2.0
species: metaid K
type: SpeciesReference

107921
stoichiometry: 1.0
species: metaid mPhos
type: SpeciesReference

107776
units: dimensionless
value: 24.4
type: LocalParameter

106386
unit: 106423
unit: 106411
unit: 106399
name: millimolar per second
type: SBMLUnitsDef

110380
stoichiometry: 1.0
species: metaid eL0
type: SpeciesReference

107026
reversible: true
product: 107074
name: PDH reaction plus first stages of the TCA cycle
type: Reaction
fast: false
product: 107111
reactant: 107038
product: 107086
modifier: 107123
is: SBO:0000176
reactant: 107062
product: 107099
reactant: 107050
kinetic law: 107135

110055
units: 106314
value: 8.76806666666666
type: LocalParameter

107387
units: 106386
value: 3.4721544
type: LocalParameter

106990
units: 106350
value: 1.0
type: LocalParameter

107715
stoichiometry: 1.0
species: metaid mO2
type: SpeciesReference

107062
stoichiometry: 2.0
species: metaid mNAD
type: SpeciesReference

107837
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

108452
units: 106531
value: 2.521086835E-5
type: LocalParameter

106266
unit: 106302
unit: 106290
unit: 106278
name: litre per millimolar squared per second
type: SBMLUnitsDef

110175
units: 106314
value: 108.4926021746
type: LocalParameter

109716
kinetic law: 109752
product: 109740
reactant: 109728
is: SBO:0000185
fast: false
reversible: true
name: bicarbonate transport
type: Reaction

metaid Py0
in compartment: metaid Vol exm
initial concentration: 0.12
initial amount: NaN
name: pyruvate
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:15361
constant: false
has only substance units: false

metaid eNa
initial concentration: 138.0
is: SBO:0000247
in compartment: metaid Vol ecs
constant: false
boundary condition: true
name: sodium ion
initial amount: NaN
has only substance units: false
is: CHEBI:29101
type: Species

106978
units: 106350
value: 0.07
type: LocalParameter

109141
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

106665
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

metaid lac
constant: false
name: lactic acid
is: CHEBI:28358
has only substance units: false
is: SBO:0000247
boundary condition: false
in compartment: metaid Vol exm
type: Species
initial amount: NaN
initial concentration: 0.0012335333887

108718
stoichiometry: 1.0
species: metaid lac
type: SpeciesReference

106314
unit: 106338
unit: 106326
name: litre per second
type: SBMLUnitsDef

108330
units: dimensionless
value: 0.43536879122666
type: LocalParameter

108391
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

108501
stoichiometry: 1.0
species: metaid Phos
type: SpeciesReference

106374
exponent: -1.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

110272
stoichiometry: 1.0
species: metaid K
type: SpeciesReference

110067
kinetic law: 110103
product: 110091
reactant: 110079
is: SBO:0000185
fast: false
reversible: true
name: CO2 diffusion
type: Reaction

107788
units: dimensionless
value: 0.25118864315096
type: LocalParameter

109873
stoichiometry: 3.0
species: metaid eNa
type: SpeciesReference

metaid Cr
is: CHEBI:16919
has only substance units: false
name: creatine
initial amount: NaN
in compartment: metaid Vol exm
initial concentration: 3.9
boundary condition: false
type: Species
constant: false
is: SBO:0000247

107727
stoichiometry: 16.0
species: metaid mHy
type: SpeciesReference

108778
units: 106531
value: 167323.655549796
type: LocalParameter

107050
stoichiometry: 1.0
species: metaid Ox
type: SpeciesReference

107825
kinetic law: 107861
product: 107849
reactant: 107837
is: SBO:0000185
fast: false
reversible: true
name: proton leak
type: Reaction

107375
units: 106350
value: 0.64
type: LocalParameter

107038
stoichiometry: 1.0
species: metaid mPy0
type: SpeciesReference

109080
stoichiometry: 1.0
species: metaid eBiC
type: SpeciesReference

109728
stoichiometry: 1.0
species: metaid BiC
type: SpeciesReference

108416
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

106278
exponent: -2.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

109406
stoichiometry: 1.0
species: metaid mHy
type: SpeciesReference

110007
kinetic law: 110043
product: 110031
reactant: 110019
is: SBO:0000185
fast: false
reversible: true
name: oxygen diffusion
type: Reaction

108440
units: 106580
value: 1.69258214789161
type: LocalParameter

110187
kinetic law: 110223
product: 110211
reactant: 110199
is: SBO:0000185
fast: false
reversible: true
name: adenosine diffusion
type: Reaction

109370
stoichiometry: 1.0
species: metaid Phos
type: SpeciesReference

106326
exponent: 1.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

108342
units: 106386
value: 0.05586005108025
type: LocalParameter

109153
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

110501
stoichiometry: 1.0
species: metaid lac
type: SpeciesReference

108090
stoichiometry: 1.0
species: metaid mCO2
type: SpeciesReference

106677
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.0
initial amount: NaN
in compartment: metaid Vol exm
name: sites on cellular proteins bound to protons
type: Species

metaid egluc
name: glucose
in compartment: metaid Vol ecs
constant: false
type: Species
is: CHEBI:17234
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: true
initial concentration: 2.08792

metaid mFAD
initial concentration: 0.1
in compartment: metaid Vol inm
name: FAD
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16238
type: Species

107606
stoichiometry: 2.0
species: metaid mNAD
type: SpeciesReference

106689
is: SBO:0000252
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: metaid Vol exm
name: sites on cellular proteins capable of binding protons
type: Species

108114
stoichiometry: 1.0
species: metaid mBiC
type: SpeciesReference

109970
stoichiometry: 1.0
species: metaid gluc
type: SpeciesReference

109606
stoichiometry: 1.0
species: metaid O2
type: SpeciesReference

110151
stoichiometry: 1.0
species: metaid Py0
type: SpeciesReference

108030
units: dimensionless
value: 6.65E-15
type: LocalParameter

108476
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

metaid CO2
type: Species
name: carbon dioxide
initial amount: NaN
in compartment: metaid Vol exm
boundary condition: false
is: CHEBI:16526
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 2.052

110247
kinetic law: 110284
product: 110272
reactant: 110259
is: SBO:0000185
fast: false
reversible: true
name: potassium diffusion
type: Reaction

107945
stoichiometry: 1.0
species: metaid mATP
type: SpeciesReference

108766
units: 106653
value: 23090.6644658719
type: LocalParameter

107533
units: 106350
value: 0.3
type: LocalParameter

106774
constant: true
units: dimensionless
value: 0.6
type: Parameter

109298
stoichiometry: 1.0
species: metaid mHy
type: SpeciesReference

106894
stoichiometry: 2.0
species: metaid ADP
type: SpeciesReference

106362
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

109541
units: 106386
value: 493.779692845496
type: LocalParameter

ORG:
  orgname: University of Essex
n:
  given: Murad
  family: Banaji

metaid mPhos
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: inorganic phosphate
in compartment: metaid Vol inm
is: CHEBI:43474
initial amount: NaN
has only substance units: false
initial concentration: 3.2

107484
stoichiometry: 1.0
species: metaid mFADH
type: SpeciesReference

107618
stoichiometry: 20.0
species: metaid Hy
type: SpeciesReference

110525
units: 106314
value: 0.0401243
type: LocalParameter

107520
units: 106350
value: 0.45454545454546
type: LocalParameter

109704
units: 106314
value: 0.09614108187134
type: LocalParameter

108464
kinetic law: 108513
product: 108501
product: 108488
reactant: 108476
is: SBO:0000176
fast: false
reversible: true
name: non-pumping ATP use
type: Reaction

108042
units: 106653
value: 1.656E-5
type: LocalParameter

107545
units: 106386
value: 1.3809705
type: LocalParameter

109504
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

106786
constant: false
units: 106507
value: NaN
type: Parameter

106882
stoichiometry: 2.0
species: metaid NAD
type: SpeciesReference

109593
kinetic law: 109632
product: 109619
reactant: 109606
is: SBO:0000185
fast: false
reversible: true
name: oxygen diffusion
type: Reaction

110235
units: 106314
value: 0.00180821003624
type: LocalParameter

107933
stoichiometry: 3.0
species: metaid Hy
type: SpeciesReference

107399
type: Reaction
reactant: 107411
fast: false
product: 107447
reactant: 107435
product: 107472
name: final stages of the TCA cycle
reactant: 107423
kinetic law: 107496
product: 107484
product: 107459
is: SBO:0000176
reversible: true

107291
stoichiometry: 1.0
species: metaid mNADH
type: SpeciesReference

108525
units: 106350
value: 0.3
type: LocalParameter

108850
units: 106653
value: 0.19554109357403
type: LocalParameter

109619
stoichiometry: 1.0
species: metaid mO2
type: SpeciesReference

106350
unit: 106374
unit: 106362
name: millimolar
type: SBMLUnitsDef

106507
unit: 106519
name: millivolt
type: SBMLUnitsDef

metaid eO2
initial concentration: 0.05
type: Species
initial amount: NaN
in compartment: metaid Vol ecs
has only substance units: false
is: SBO:0000247
boundary condition: true
name: oxygen
is: CHEBI:15379
constant: false

metaid mFADH
constant: false
type: Species
in compartment: metaid Vol inm
initial amount: NaN
initial concentration: 1.22
has only substance units: false
is: SBO:0000247
name: FADH2
is: CHEBI:17877
boundary condition: false

107643
units: dimensionless
value: 0.25118864315096
type: LocalParameter

106858
product: 106930
is: SBO:0000176
type: Reaction
product: 106918
reversible: true
product: 106954
reactant: 106894
reactant: 106906
fast: false
kinetic law: 106966
reactant: 106870
reactant: 106882
product: 106942
name: glycolysis in one step

108054
units: 106653
value: 9.651E-14
type: LocalParameter

109994
units: 106314
value: 0.00982672403768
type: LocalParameter

110091
stoichiometry: 1.0
species: metaid CO2
type: SpeciesReference

metaid PCr
in compartment: metaid Vol exm
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:17287
initial concentration: 5.85
name: phosphocreatine
type: Species
initial amount: NaN

108138
units: 106653
value: 0.02699531802578
type: LocalParameter

109430
units: 106435
value: 4.7876514649E-4
type: LocalParameter

109238
units: 106266
value: 1000.0
type: LocalParameter

108537
units: 106386
value: 0.14897283194444
type: LocalParameter

109668
stoichiometry: 1.0
species: metaid CO2
type: SpeciesReference

106399
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid suc
in compartment: metaid Vol inm
is: CHEBI:15741
initial concentration: 0.1
constant: false
name: succinate
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

106918
stoichiometry: 2.0
species: metaid NADH
type: SpeciesReference

107557
product: 107606
reactant: 107569
product: 107618
reversible: true
reactant: 107593
type: Reaction
is: SBO:0000176
name: oxidation of NADH
reactant: 107581
kinetic law: 107630
fast: false

109516
stoichiometry: 1.0
species: metaid mADP
type: SpeciesReference

metaid ePy0
initial concentration: 0.12
boundary condition: true
is: CHEBI:15361
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
in compartment: metaid Vol ecs
name: pyruvate
type: Species

109274
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

106870
stoichiometry: 1.0
species: metaid gluc
type: SpeciesReference

106798
constant: false
units: 106386
value: NaN
type: Parameter

108742
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

metaid Vol inm
is: GO:0005759
constant: true
size: 0.08
spatial dimensions: 3.0
name: mitochondrial matrix
type: Compartment

108488
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

106230
exponent: 3.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

108066
units: 106653
value: 4.585E-14
type: LocalParameter

109580
units: dimensionless
value: 7.2
type: LocalParameter

metaid O2
initial concentration: 0.0455
constant: false
initial amount: NaN
name: oxygen
is: CHEBI:15379
has only substance units: false
in compartment: metaid Vol exm
boundary condition: false
is: SBO:0000247
type: Species

109554
units: dimensionless
value: 0.8
type: LocalParameter

107655
units: dimensionless
value: 0.2
type: LocalParameter

108790
kinetic law: 108838
product: 108826
product: 108814
reactant: 108802
is: SBO:0000176
fast: false
reversible: true
name: production and dissociation of carbonic acid
type: Reaction

metaid eL0
boundary condition: true
initial amount: NaN
type: Species
in compartment: metaid Vol ecs
has only substance units: false
is: CHEBI:24996
is: SBO:0000247
constant: false
initial concentration: 1.902
name: lactate

107099
stoichiometry: 2.0
species: metaid mNADH
type: SpeciesReference

metaid Ox
boundary condition: false
in compartment: metaid Vol inm
has only substance units: false
is: CHEBI:16452
type: Species
initial concentration: 0.54
constant: false
name: oxaloacetate
is: SBO:0000247
initial amount: NaN

109567
units: dimensionless
value: 0.1111
type: LocalParameter

109226
units: 106266
value: 10000.0
type: LocalParameter

107569
stoichiometry: 2.0
species: metaid mNADH
type: SpeciesReference

106906
stoichiometry: 2.0
species: metaid Phos
type: SpeciesReference

metaid L0
constant: false
is: SBO:0000247
in compartment: metaid Vol exm
type: Species
initial amount: NaN
name: lactate
is: CHEBI:24996
initial concentration: 2.0
has only substance units: false
boundary condition: false

109286
stoichiometry: 1.0
species: metaid mPy0
type: SpeciesReference

108730
stoichiometry: 1.0
species: metaid L0
type: SpeciesReference

110211
stoichiometry: 1.0
species: metaid Ad
type: SpeciesReference

107957
stoichiometry: 3.0
species: metaid mHy
type: SpeciesReference

108549
kinetic law: 108598
product: 108586
product: 108574
reactant: 108561
is: SBO:0000176
fast: false
reversible: true
name: adenlyate kinase reaction
type: Reaction

108694
units: 106653
value: 0.01386172409053
type: LocalParameter

108646
stoichiometry: 1.0
species: metaid AMP
type: SpeciesReference

106701
constant: true
units: 106350
value: 0.11366534740545
type: Parameter

metaid BiC
in compartment: metaid Vol exm
type: Species
initial amount: NaN
is: CHEBI:17544
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 19.0460292836137
name: bicarbonate ion

108959
kinetic law: 109008
product: 108996
product: 108984
reactant: 108972
is: SBO:0000176
fast: false
reversible: true
name: lactic acid dissociation
type: Reaction

106762
constant: true
units: 106507
value: 150.0
type: Parameter

107315
stoichiometry: 1.0
species: metaid mATP
type: SpeciesReference

110259
stoichiometry: 1.0
species: metaid eK
type: SpeciesReference

109442
units: 106218
value: 0.00186561232274
type: LocalParameter

109358
product: 109394
fast: false
name: phosphate transport
kinetic law: 109418
is: SBO:0000185
type: Reaction
product: 109406
reversible: true
reactant: 109382
reactant: 109370

107279
stoichiometry: 1.0
species: metaid suc
type: SpeciesReference

106555
exponent: 1.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

106495
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

106616
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

108899
stoichiometry: 1.0
species: 106689
type: SpeciesReference

metaid ADP
name: ADP
is: CHEBI:16761
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 0.35
in compartment: metaid Vol exm
has only substance units: false
boundary condition: false
constant: false

110404
stoichiometry: 1.0
species: metaid L0
type: SpeciesReference

107593
stoichiometry: 22.0
species: metaid mHy
type: SpeciesReference

109824
stoichiometry: 3.0
species: metaid Na
type: SpeciesReference

107679
units: 106471
value: 0.63086721428571
type: LocalParameter

110452
units: 106218
value: 5.10346312866496E-7
type: LocalParameter

metaid NADH
is: CHEBI:16908
initial amount: NaN
constant: false
name: NADH
has only substance units: false
type: Species
initial concentration: 0.0029702970297
boundary condition: false
in compartment: metaid Vol exm
is: SBO:0000247

109837
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

108682
units: 106653
value: 1.2195206724773E-6
type: LocalParameter

108658
stoichiometry: 1.0
species: metaid Ad
type: SpeciesReference

metaid mNADH
boundary condition: false
type: Species
is: CHEBI:16908
in compartment: metaid Vol inm
is: SBO:0000247
initial concentration: 0.90909090909091
constant: false
has only substance units: false
initial amount: NaN
name: NADH

107267
stoichiometry: 1.0
species: metaid mCO2
type: SpeciesReference

metaid eHy
has only substance units: false
in compartment: metaid Vol ecs
name: hydrogen ion
boundary condition: true
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:15378
initial concentration: 5.623413252E-5

106750
constant: false
units: 106507
value: NaN
type: Parameter

109454
units: dimensionless
value: 0.5
type: LocalParameter

108150
units: 106531
value: 34.1712886402221
type: LocalParameter

106483
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

106604
exponent: 2.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

MODEL4992089662
species: metaid mATP
species: metaid eHy
reaction: 110247
parameter: 106786
species: metaid gluc
species: metaid ATP
species: 106677
time units: 013121
species: metaid eL
substance units: 106194
reaction: 109250
reaction: 107399
reaction: 109593
species: metaid K
length unit: length
units def: 106386
species: metaid NAD
curated: false
reaction: 110477
area units: area
species: metaid mFADH
reaction: 108464
species: metaid AMP
reaction: 108354
species: metaid eO2
units def: 106471
units def: 106218
species: metaid eAd
reaction: 110067
species: metaid CO2
species: metaid Ox
species: metaid Phos
species: metaid Ad
is: http://identifiers.org/taxonomy/9606
species: metaid mCO2
species: metaid PCr
species: metaid Na
reaction: 110187
species: metaid Cr
parameter: 106726
parameter: 106750
rule: 106834
species: metaid mNAD
reaction: 109044
reaction: 109946
species: metaid mADP
reaction: 109788
species: metaid eBiC
reaction: 110007
parameter: 106798
species: metaid ADP
name: Banaji2005_Brain_Cell_Metabolism
reaction: 108634
reaction: 107897
species: metaid eNa
reaction: 107825
units def: 106314
reaction: 109358
species: metaid ePy0
reaction: 109716
species: metaid L0
species: metaid mO2
rule: 106846
species: metaid lac
species: metaid mBiC
compartment: metaid Vol ecs
reaction: 108875
units def: 106194
species: metaid BiC
species: metaid Py0
reaction: 109467
reaction: 107026
species: metaid mPhos
reaction: 108078
species: metaid egluc
species: metaid suc
parameter: 106774
species: metaid mNADH
reaction: 108706
reaction: 107691

107667
units: 106350
value: 0.05
type: LocalParameter

106568
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

110368
fast: false
name: lactate transport
product: 110404
is: SBO:0000185
reactant: 110392
kinetic law: 110428
product: 110416
reactant: 110380
reversible: true
type: Reaction

110464
units: dimensionless
value: 0.5
type: LocalParameter

108887
stoichiometry: 1.0
species: 106677
type: SpeciesReference

metaid ATP
has only substance units: false
is: CHEBI:15422
initial concentration: 3.0
initial amount: NaN
is: SBO:0000247
name: ATP
boundary condition: false
constant: false
type: Species
in compartment: metaid Vol exm

107909
stoichiometry: 1.0
species: metaid mADP
type: SpeciesReference

metaid K
constant: false
boundary condition: false
type: Species
name: potassium ion
has only substance units: false
is: SBO:0000247
initial concentration: 180.0
is: CHEBI:29103
initial amount: NaN
in compartment: metaid Vol exm

109262
stoichiometry: 1.0
species: metaid Py0
type: SpeciesReference

107111
stoichiometry: 1.0
species: metaid mHy
type: SpeciesReference

metaid Phos
is: CHEBI:43474
has only substance units: false
name: inorganic phosphate
type: Species
initial amount: NaN
constant: false
in compartment: metaid Vol exm
initial concentration: 1.5
is: SBO:0000247
boundary condition: false

107459
stoichiometry: 1.0
species: metaid mNADH
type: SpeciesReference

107339
units: 106350
value: 0.3
type: LocalParameter

metaid eL
name: lactic acid
initial concentration: 7.7505304385E-4
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: true
in compartment: metaid Vol ecs
is: CHEBI:28358
has only substance units: false

108875
kinetic law: 108923
product: 108911
product: 108899
reactant: 108887
is: SBO:0000176
fast: false
reversible: true
name: general buffer reaction
type: Reaction

109467
reactant: 109479
product: 109516
kinetic law: 109528
fast: false
product: 109504
name: ATP-ADP antiport
is: SBO:0000185
reversible: true
type: Reaction
reactant: 109492

108802
stoichiometry: 1.0
species: metaid CO2
type: SpeciesReference

110356
units: 106314
value: 0.0023782802439
type: LocalParameter

109056
stoichiometry: 1.0
species: metaid eCO2
type: SpeciesReference

109800
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

109897
units: 106350
value: 1.4
type: LocalParameter

108294
units: 106350
value: 0.0062
type: LocalParameter

106206
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

108102
stoichiometry: 1.0
species: metaid mHy
type: SpeciesReference

106726
constant: true
units: 106507
value: 26.73
type: Parameter

metaid eK
is: CHEBI:29103
name: potassium ion
in compartment: metaid Vol ecs
constant: false
initial concentration: 2.8
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: true
has only substance units: false

106471
unit: 106495
unit: 106483
name: millimole per second
type: SBMLUnitsDef

106519
exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT
type: SBMLUnit

metaid mO2
type: Species
initial amount: NaN
constant: false
has only substance units: false
in compartment: metaid Vol inm
name: oxygen
is: CHEBI:15379
initial concentration: 0.02275
is: SBO:0000247
boundary condition: false

metaid mNAD
constant: false
name: NAD
boundary condition: false
type: Species
is: CHEBI:15846
initial amount: NaN
in compartment: metaid Vol inm
initial concentration: 9.09090909090909
has only substance units: false
is: SBO:0000247

109250
is: SBO:0000185
fast: false
kinetic law: 109310
name: pyruvate transport
reactant: 109262
type: Reaction
product: 109286
reversible: true
product: 109298
reactant: 109274

106411
exponent: -1.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

metaid AMP
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
in compartment: metaid Vol exm
name: AMP
initial concentration: 0.11366534740545
is: CHEBI:16027
is: SBO:0000247

107447
stoichiometry: 1.0
species: metaid Ox
type: SpeciesReference

108814
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

metaid mHy
constant: false
initial amount: NaN
name: hydrogen ion
type: Species
is: SBO:0000247
is: CHEBI:15378
initial concentration: 2.13796209E-5
has only substance units: false
boundary condition: false
in compartment: metaid Vol inm

109909
units: dimensionless
value: 0.01088888888889
type: LocalParameter

109812
stoichiometry: 2.0
species: metaid eK
type: SpeciesReference

109068
stoichiometry: 1.0
species: metaid eHy
type: SpeciesReference

107581
stoichiometry: 1.0
species: metaid mO2
type: SpeciesReference

ORG:
  orgname: University of Manchester
n:
  given: Kieran
  family: Smallbone

110416
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

109479
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

108863
units: 106531
value: 247.520371612693
type: LocalParameter

metaid Ad
has only substance units: false
type: Species
constant: false
is: CHEBI:16335
is: SBO:0000247
initial concentration: 1.0E-5
in compartment: metaid Vol exm
boundary condition: false
name: adenosine
initial amount: NaN

106810
constant: true
units: 106386
value: 0.12973000591182
type: Parameter

106628
unit: 106641
name: per millivolt
type: SBMLUnitsDef

110440
units: 106435
value: 1.1490363516E-4
type: LocalParameter

108078
kinetic law: 108126
product: 108114
product: 108102
reactant: 108090
is: SBO:0000176
fast: false
reversible: true
name: production and dissociation of carbonic acid
type: Reaction

107873
units: 106471
value: 6.278528285E-5
type: LocalParameter

106714
constant: true
units: 106350
value: 3.0
type: Parameter

106218
unit: 106254
unit: 106242
unit: 106230
name: litre millimolar cubed per second
type: SBMLUnitsDef

108270
units: 106435
value: 0.24
type: LocalParameter

108210
stoichiometry: 1.0
species: metaid L0
type: SpeciesReference

107885
units: 106628
value: 0.038
type: LocalParameter

109958
stoichiometry: 1.0
species: metaid egluc
type: SpeciesReference

108561
stoichiometry: 2.0
species: metaid ADP
type: SpeciesReference

108186
stoichiometry: 1.0
species: metaid NADH
type: SpeciesReference

metaid mBiC
initial concentration: 90.9883299405421
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:17544
type: Species
name: bicarbonate ion
in compartment: metaid Vol inm
initial amount: NaN

metaid eCO2
in compartment: metaid Vol ecs
is: CHEBI:16526
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: 1.7838252
is: SBO:0000247
type: Species
name: carbon dioxide
constant: false

110332
stoichiometry: 1.0
species: metaid Na
type: SpeciesReference

108826
stoichiometry: 1.0
species: metaid BiC
type: SpeciesReference

108006
units: dimensionless
value: 1.346E-8
type: LocalParameter

109032
units: 106531
value: 167323.655549796
type: LocalParameter

107435
stoichiometry: 1.0
species: metaid mFAD
type: SpeciesReference

109190
stoichiometry: 1.0
species: metaid mHy
type: SpeciesReference

109788
fast: false
reactant: 109800
reversible: true
kinetic law: 109885
type: Reaction
reactant: 109812
product: 109861
reactant: 109824
name: active sodium potassium exchange
is: SBO:0000185
product: 109837
product: 109849
product: 109873

metaid eBiC
in compartment: metaid Vol ecs
name: bicarbonate ion
is: CHEBI:17544
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000247
initial concentration: 25.0599030317216
type: Species
constant: false

108911
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

110127
kinetic law: 110163
product: 110151
reactant: 110139
is: SBO:0000185
fast: false
reversible: true
name: pyruvate diffusion
type: Reaction

107231
stoichiometry: 1.0
species: metaid mNAD
type: SpeciesReference

106423
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

108379
stoichiometry: 1.0
species: metaid ADP
type: SpeciesReference

109680
stoichiometry: 1.0
species: metaid mCO2
type: SpeciesReference

108198
stoichiometry: 1.0
species: metaid Hy
type: SpeciesReference

106738
constant: true
units: dimensionless
value: 3.0
type: Parameter

108282
units: 106350
value: 0.03
type: LocalParameter

107897
type: Reaction
reactant: 107933
is: SBO:0000176
fast: false
reactant: 107921
product: 107945
product: 107957
kinetic law: 107970
reversible: true
reactant: 107909
name: oxidative phosphorylation

110320
stoichiometry: 1.0
species: metaid eNa
type: SpeciesReference

106338
exponent: -1.0
scale: 1
multipler: 1.0
kind: SECOND
type: SBMLUnit

108018
units: dimensionless
value: 7.739E-7
type: LocalParameter

109044
kinetic law: 109092
product: 109080
product: 109068
reactant: 109056
is: SBO:0000176
fast: false
reversible: true
name: production and dissociation of carbonic acid
type: Reaction

metaid mPy0
name: pyruvate
is: SBO:0000247
boundary condition: false
initial concentration: 0.38218288373136
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:15361
constant: false
in compartment: metaid Vol inm

109776
units: 106314
value: 1.646537405E-5
type: LocalParameter

107982
units: dimensionless
value: 1710000.0
type: LocalParameter

107423
stoichiometry: 1.0
species: metaid mNAD
type: SpeciesReference

107508
units: 106350
value: 0.1
type: LocalParameter

108610
units: 106531
value: 1055.0
type: LocalParameter

107147
units: 106350
value: 0.062
type: LocalParameter

109322
units: 106435
value: 1.372460087E-5
type: LocalParameter

metaid eAd
constant: false
in compartment: metaid Vol ecs
boundary condition: true
name: adenosine
initial concentration: 1.0E-5
type: Species
is: SBO:0000247
is: CHEBI:16335
initial amount: NaN
has only substance units: false

110139
stoichiometry: 1.0
species: metaid ePy0
type: SpeciesReference

108403
stoichiometry: 1.0
species: metaid Cr
type: SpeciesReference

106435
unit: 106459
unit: 106447
name: millimolar squared
type: SBMLUnitsDef

110079
stoichiometry: 1.0
species: metaid eCO2
type: SpeciesReference

107472
stoichiometry: 1.0
species: metaid mHy
type: SpeciesReference

109934
units: 106471
value: 0.7293709852
type: LocalParameter

metaid mATP
constant: false
in compartment: metaid Vol inm
has only substance units: false
is: SBO:0000247
initial concentration: 14.1732283464567
is: CHEBI:15422
name: ATP
type: Species
boundary condition: false
initial amount: NaN

metaid gluc
boundary condition: false
has only substance units: false
name: glucose
initial concentration: 1.4
in compartment: metaid Vol exm
is: SBO:0000247
is: CHEBI:17234
type: Species
constant: false
initial amount: NaN

metaid Na
initial concentration: 15.0
name: sodium ion
initial amount: NaN
is: CHEBI:29101
boundary condition: false
constant: false
type: Species
is: SBO:0000247
in compartment: metaid Vol exm
has only substance units: false

108162
kinetic law: 108234
name: lactate to pyruvate interconversion
reactant: 108198
reversible: true
reactant: 108186
product: 108222
reactant: 108174
is: SBO:0000176
type: Reaction
product: 108210
fast: false

106942
stoichiometry: 4.0
species: metaid Hy
type: SpeciesReference

metaid Vol ecs
is: GO:0005576
constant: true
size: 0.2
spatial dimensions: 3.0
name: extracellular
type: Compartment

107195
units: 106386
value: 0.19657949068328
type: LocalParameter

108935
units: 106653
value: 0.28881132523331
type: LocalParameter

106447
exponent: 2.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

110489
stoichiometry: 1.0
species: metaid eL
type: SpeciesReference

107703
stoichiometry: 2.0
species: metaid mFADH
type: SpeciesReference

107849
stoichiometry: 1.0
species: metaid mHy
type: SpeciesReference

106531
unit: 106568
unit: 106555
unit: 106543
name: per millimolar per second
type: SBMLUnitsDef

107159
units: 106350
value: 0.90909090909091
type: LocalParameter

109334
units: 106218
value: 5.3997401390841E-6
type: LocalParameter

107255
stoichiometry: 1.0
species: metaid mPhos
type: SpeciesReference

110392
stoichiometry: 1.0
species: metaid eHy
type: SpeciesReference

108622
units: 106531
value: 379.0
type: LocalParameter

109849
stoichiometry: 1.0
species: metaid Phos
type: SpeciesReference

W3 CDTF: Fri Dec 05 00:00:00 GMT 2008

107411
stoichiometry: 1.0
species: metaid suc
type: SpeciesReference

108586
stoichiometry: 1.0
species: metaid AMP
type: SpeciesReference

metaid Hy
boundary condition: false
initial amount: NaN
in compartment: metaid Vol exm
constant: false
is: CHEBI:15378
has only substance units: false
is: SBO:0000247
type: Species
name: hydrogen ion
initial concentration: 8.511380382E-5

107994
units: 106350
value: -34.9815865155365
type: LocalParameter

109764
units: 106314
value: 7.865980171E-5
type: LocalParameter

107207
reactant: 107255
kinetic law: 107327
reactant: 107243
name: middle stages of the TCA cycle
reversible: true
product: 107279
is: SBO:0000176
product: 107315
product: 107303
fast: false
product: 107267
product: 107291
reactant: 107219
reactant: 107231
type: Reaction

109020
units: 106653
value: 23090.6644658719
type: LocalParameter

109946
kinetic law: 109982
product: 109970
reactant: 109958
is: SBO:0000185
fast: false
reversible: true
name: glucose transport
type: Reaction

106930
stoichiometry: 2.0
species: metaid Py0
type: SpeciesReference

108222
stoichiometry: 1.0
species: metaid NAD
type: SpeciesReference

108174
stoichiometry: 1.0
species: metaid Py0
type: SpeciesReference

109740
stoichiometry: 1.0
species: metaid mBiC
type: SpeciesReference

108996
stoichiometry: 1.0
species: metaid eHy
type: SpeciesReference

metaid AKG
constant: false
initial amount: NaN
in compartment: metaid Vol inm
type: Species
initial concentration: 0.1
boundary condition: false
is: CHEBI:16810
name: alpha-ketoglutarate
has only substance units: false
is: SBO:0000247

107303
stoichiometry: 1.0
species: metaid mHy
type: SpeciesReference

109346
units: dimensionless
value: 0.5
type: LocalParameter

106543
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

107243
stoichiometry: 1.0
species: metaid mADP
type: SpeciesReference

110477
kinetic law: 110513
product: 110501
reactant: 110489
is: SBO:0000185
fast: false
reversible: true
name: lactic acid diffusion
type: Reaction

108947
units: 106531
value: 678.647439710924
type: LocalParameter

107183
units: 106350
value: 0.03821828837314
type: LocalParameter

106459
exponent: -2.0
scale: 1
multipler: 1.0
kind: LITRE
type: SBMLUnit

107219
stoichiometry: 1.0
species: metaid AKG
type: SpeciesReference

W3 CDTF: Fri Feb 03 11:12:16 GMT 2012

108634
kinetic law: 108670
product: 108658
reactant: 108646
is: SBO:0000176
fast: false
reversible: true
name: AMP degradation
type: Reaction

106592
exponent: -2.0
scale: -3
multipler: 1.0
kind: MOLE
type: SBMLUnit

metaid mADP
initial concentration: 0.82677165354331
has only substance units: false
in compartment: metaid Vol inm
is: SBO:0000247
name: ADP
constant: false
type: Species
initial amount: NaN
is: CHEBI:16761
boundary condition: false

108574
stoichiometry: 1.0
species: metaid ATP
type: SpeciesReference

orgname: University of Manchester

given: Kieran
family: Smallbone

given: Murad
family: Banaji

ORG:
  orgname: University of Essex

W3 CDTF: Fri Feb 03 11:12:16 GMT 2012

given: Kieran
family: Smallbone

W3 CDTF: Fri Feb 03 11:12:16 GMT 2012

orgname: University of Manchester

orgname: University of Essex

n:
  given: Murad
  family: Banaji

W3 CDTF: Fri Feb 03 11:12:16 GMT 2012