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initial amount: NaN
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type: Species

099834
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species: 458526
type: SpeciesReference

099642
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species: 458486
type: SpeciesReference

099569
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

099726
local parameters: 099750
local parameters: 099738
notes: kf*RasGDP_minus_NF1_Pi-kb*Pi*RasGDP_NF1
type: KineticLaw

458646
kinetic law: 099930
product: 099918
reactant: 099906
reactant: 099894
notes: Binding of NF1 to Ras.GTP NF1 is a mammalian GAP Kd = 5.3 uM Table 3, Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true
type: Reaction

099858
local parameters: 099882
local parameters: 099870
notes: kf*RasGDP_NF1-kb*RasGDP*NF1
type: KineticLaw

099942
units: 099557
value: 6.283184040672E-13
type: LocalParameter

099702
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species: 458406
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kind: LITRE
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458426
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boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
in compartment: 458388
type: Species

099870
units: 099520
value: 2.43474E-11
type: LocalParameter

458606
kinetic law: 099786
product: 099774
reactant: 099762
notes: Activation of Ras by GAP (i.e NF1) Kf = 418 /sec Kb = 5.5 /sec Table 3, Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true
type: Reaction

458466
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boundary condition: false
has only substance units: false
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initial amount: NaN
in compartment: 458388
type: Species

099762
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species: 458446
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099690
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species: 458486
type: SpeciesReference

099918
stoichiometry: 1.0
species: 458446
type: SpeciesReference

099654
local parameters: 099678
local parameters: 099666
notes: kf*RasGTP_minus_NF1_star_-kb*RasGDP_minus_NF1_Pi
type: KineticLaw

099798
units: 099520
value: 2.188648E-10
type: LocalParameter

458586
kinetic law: 099726
product: 099714
product: 099702
reactant: 099690
notes: Second step in hydrolysis of GTP bound to Ras is complexed with NF1 - a mammalian GAP Kf = 40 /sec Kb = 108 /M/sec = 1.08e-04 /uM/sec Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true
type: Reaction

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scale: -6
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kind: MOLE
type: SBMLUnit

458626
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product: 099846
product: 099834
reactant: 099822
notes: Dissociation of NF1 from Ras.GDP NF1 is a mammalian GAP Kf = 46.5 /sec Kb = 1.2 /sec/uM Table 3, Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true
type: Reaction

099894
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species: 458426
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kind: MOLE
type: SBMLUnit

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scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

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product: 099642
reactant: 099629
notes: First step in hydrolysis of GTP bound to Ras complexed with NF1 - a mammalian GAP Kf = 19.5 /sec Kb = 0.22 /sec Table 3, Phillips RA et al 2003 Biochemistry 3956-3965
fast: false
reversible: true
type: Reaction

099822
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species: 458506
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value: 1.15192E-13
type: LocalParameter

458486
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boundary condition: false
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initial concentration: 0.0
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value: 2.0944E-11
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458546
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boundary condition: false
has only substance units: false
initial concentration: 9.99936338171632
initial amount: NaN
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099930
local parameters: 099954
local parameters: 099942
notes: kf*RasGTP*NF1-kb*RasGTP_minus_NF1
type: KineticLaw

099846
stoichiometry: 1.0
species: 458546
type: SpeciesReference

458387
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

099954
units: 099520
value: 3.330096E-12
type: LocalParameter

458506
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boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 458388
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099714
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species: 458506
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stoichiometry: 1.0
species: 458546
type: SpeciesReference

458406
constant: false
boundary condition: false
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initial concentration: 0.0
initial amount: NaN
in compartment: 458388
type: Species

099774
stoichiometry: 1.0
species: 458466
type: SpeciesReference

099666
units: 099520
value: 1.02102E-11
type: LocalParameter

458526
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 458388
type: Species

099882
units: 099557
value: 6.283184040672E-13
type: LocalParameter

MODEL4968912141
length unit: length
area units: area
reaction: 458606
species: 458526
species: 458506
reaction: 458566
units def: 099605
units def: 099520
is described by: http://identifiers.org/pubmed/12667087
units def: 099557
name: Phillips2003_RasGTPase
species: 458466
notes: Ras is an important regulator of cell growth in all eukaryotic cells. The model represent hydrolysis of active Ras-bound GTP to give inactive Ras-bound GDP catalyzed by GTPase activating proteins i.e NF1. The inactive Ras-bound GDP turns signalling off. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
volume units: metaid_0000217
time units: 013121
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species: 458486
substance units: 099605
species: 458406
reaction: 458626
species: 458426
reaction: 458586
curated: false
type: SBMLModel

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size: 5.236E-13
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value: 5.654816288352E-17
type: LocalParameter

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species: 458466
type: SpeciesReference

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value: 2.8798E-12
type: LocalParameter

099593
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

099786
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local parameters: 099798
notes: kf*RasGTP_minus_NF1-kb*RasGTP_minus_NF1_star_
type: KineticLaw