071183
local parameters: 071207
local parameters: 071195
notes: kf*GC_slash_NO_sGCpart_act-kb*GC_slash_NO_sGCfull_act
type: KineticLaw

129388
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1000.0
initial amount: NaN
in compartment: 129308
type: Species

071123
local parameters: 071147
local parameters: 071135
notes: kf*GC_slash_NO_sGCpart_act*GC_slash_NO_a-kb*GC_slash_NO_sGCfull_act
type: KineticLaw

071147
units: 070906
value: 0.0
type: LocalParameter

129408
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 129308
type: Species

071014
stoichiometry: 1.0
species: 129448
type: SpeciesReference

071315
stoichiometry: 1.0
species: 129368
type: SpeciesReference

071413
units: 070906
value: 6.66666666666667E-17
type: LocalParameter

071267
units: 070906
value: 1.16666666666667E-19
type: LocalParameter

071376
stoichiometry: 1.0
species: 129408
type: SpeciesReference

129289
constant: true
size: 1.0E-18
spatial dimensions: 3.0
type: Compartment

071352
units: 070906
value: 2.66666666666667E-16
type: LocalParameter

071243
stoichiometry: 1.0
species: 129448
type: SpeciesReference

129368
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 129308
type: Species

129488
kinetic law: 071050
product: 071038
reactant: 071026
reactant: 071014
notes: Rates at 4 degree C... used directly from paper by Condorelli P, 2001, Biophysical J, 80:2110-2119, which in turn have been obtained mainly from Zhao et al., PNAS,96:14753-14758.
fast: false
reversible: true
type: Reaction

129528
kinetic law: 071183
product: 071171
reactant: 071159
notes: Rates used directly from Condorelli et al., 2001, Biophysical J, 80:2110-2119 .... Rates originally from Zhao et al., 1999, PNAS, 96:14753-14758 from stopped flow spectroscopy experiments performed 4 degree C.
fast: false
reversible: true
type: Reaction

071291
stoichiometry: 1.0
species: 129388
type: SpeciesReference

071099
stoichiometry: 1.0
species: 129428
type: SpeciesReference

129569
kinetic law: 071401
product: 071389
product: 071376
reactant: 071364
fast: false
reversible: false
type: Reaction

071062
units: 070942
value: 1.63333333333333E-15
type: LocalParameter

070966
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

071074
units: 070906
value: 5.83333333333333E-16
type: LocalParameter

071002
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE
type: SBMLUnit

071327
local parameters: 071352
local parameters: 071340
notes: k1*GC_slash_GTP*GC_slash_NO_sGCfull_act-k2*GC_slash_NO_sGCfull_act_slash_full_act_sGC_slash_full_act_sGC_cplx
type: KineticLaw

129548
kinetic law: 071255
product: 071243
product: 071231
reactant: 071219
notes: This is a modification by Condorelli et al., 2001, Biophys J of the recent binding scheme of Zhao et al., to include the NO dissociation from fully active complex of sGC... The dissociation is characterised by the respective first order rate constants depicted in the model... Rates are obtained at 4 degree C...
fast: false
reversible: true
type: Reaction

070978
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

071279
units: 070942
value: 0.0
type: LocalParameter

071401
local parameters: 071413
notes: k3*GC_slash_NO_sGCfull_act_slash_full_act_sGC_slash_full_act_sGC_cplx
type: KineticLaw

129508
kinetic law: 071123
product: 071111
reactant: 071099
reactant: 071087
notes: Rates from stopped flow experiments performed at 4 degree C from Zhao et al., 1999, PNAS,96:14753-14758. Same rates used by Condorelli P, for simulations...
fast: false
reversible: true
type: Reaction

071135
units: 070942
value: 2.8E-18
type: LocalParameter

129468
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 129308
type: Species

070918
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

129448
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.0
initial amount: NaN
in compartment: 129308
type: Species

071195
units: 070906
value: 1.015E-19
type: LocalParameter

071303
stoichiometry: 1.0
species: 129348
type: SpeciesReference

129328
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 129308
type: Species

071219
stoichiometry: 1.0
species: 129348
type: SpeciesReference

071026
stoichiometry: 1.0
species: 129468
type: SpeciesReference

071255
local parameters: 071279
local parameters: 071267
notes: kf*GC_slash_NO_sGCfull_act-kb*GC_slash_NO*GC_slash_sGC_basal
type: KineticLaw

MODEL4780441670
units def: 070942
species: 129348
reaction: 129548
species: 129368
reaction: 129528
length unit: length
species: 129408
reaction: 129488
name: Condorelli2001_GuanylateCyclase
curated: false
reaction: 129569
units def: 070906
notes: This model features the observations of Condorelli P, George SC. Biophys J. (2001) 80(5):2110-9. They propose a in vivo mechanism for the binding of free NO to sGC based on in vitro data within both pulmonary and vascular smooth muscle. All the parameters used have been obtained from reported results based on experiments. One important conclusion they make is that control of sGC in vivo is most likely to be ultra-sensitive and that activation in vivo occurs at lower NO concentrations than reported. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
species: 129328
reaction: 129508
species: 129468
compartment: 129289
area units: area
compartment: 129308
is described by: http://identifiers.org/pubmed/11325714
type: SBMLModel
species: 129448
units def: 070990
time units: 013121
species: 129388
volume units: metaid_0000217
species: 129428
reaction: 129568
substance units: 070990

071171
stoichiometry: 1.0
species: 129348
type: SpeciesReference

129348
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 129308
type: Species

129568
kinetic law: 071327
product: 071315
reactant: 071303
reactant: 071291
notes: Km values for the basal and fully activated forms of sGC have been determined as 85-120 uM and 58 uM, respectively ... (Ignarro et al., 1982, BBA, 718:49-59)..and the same has been used by Condorelli et al., 2001... Vmax values are around 10-100 nmol/min/mg (without NO) and 10-40 umol/min/mg (with NO) ..... thru personal correspondence with T Bellamy,
fast: false
reversible: true
type: Reaction

071159
stoichiometry: 1.0
species: 129328
type: SpeciesReference

071340
units: 070942
value: 5.74716666666667E-18
type: LocalParameter

071038
stoichiometry: 1.0
species: 129328
type: SpeciesReference

071087
stoichiometry: 1.0
species: 129328
type: SpeciesReference

070930
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND
type: SBMLUnit

071207
units: 070906
value: 2.33333333333333E-20
type: LocalParameter

071364
stoichiometry: 1.0
species: 129368
type: SpeciesReference

129308
constant: true
size: 1.6667E-18
spatial dimensions: 3.0
type: Compartment

129428
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.1
initial amount: NaN
in compartment: 129308
type: Species

071050
local parameters: 071074
local parameters: 071062
notes: kf*GC_slash_sGC_basal*GC_slash_NO-kb*GC_slash_NO_sGCpart_act
type: KineticLaw

070954
exponent: 2.0
scale: 0
multipler: 1.0
kind: LITRE
type: SBMLUnit

071111
stoichiometry: 1.0
species: 129348
type: SpeciesReference

071231
stoichiometry: 1.0
species: 129468
type: SpeciesReference

071389
stoichiometry: 1.0
species: 129348
type: SpeciesReference