033962
stoichiometry: 1.0
species: 299843
type: SpeciesReference

301224
product: 033422
reactant: 033410
notes: PMID: 15044096
fast: false
reversible: false
type: Reaction

032690
stoichiometry: 1.0
species: 299838
type: SpeciesReference

026623
stoichiometry: 1.0
species: 299350
type: SpeciesReference

300703
product: 028759
reactant: 028747
notes: Notes by CellDesigner PMID: 10766737 reaction: direct
fast: false
reversible: false
type: Reaction

028711
stoichiometry: 1.0
species: 299503
type: SpeciesReference

301263
product: 033758
reactant: 033746
notes: PMID: 16984923
fast: false
reversible: false
type: Reaction

019848
stoichiometry: 1.0
species: 298881
type: SpeciesReference

029011
stoichiometry: 1.0
species: 299843
type: SpeciesReference

299396
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCL1
type: Species

299215
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: FZR1
type: Species

301110
product: 032342
reactant: 032330
notes: PMID: 16325355
fast: false
reversible: false
type: Reaction

301199
product: 033182
reactant: 033170
notes: PMID: 15195143
fast: false
reversible: false
type: Reaction

028483
stoichiometry: 1.0
species: 299843
type: SpeciesReference

023546
stoichiometry: 1.0
species: 299148
type: SpeciesReference

031705
stoichiometry: 1.0
species: 298923
type: SpeciesReference

024002
stoichiometry: 1.0
species: 299215
type: SpeciesReference

300972
product: 030997
reactant: 030985
notes: Notes by CellDesigner PMID: 15580623 reaction: direct
fast: false
reversible: false
type: Reaction

031153
stoichiometry: 1.0
species: 298923
type: SpeciesReference

028303
stoichiometry: 1.0
species: 299650
type: SpeciesReference

300781
product: 029467
reactant: 029455
notes: Notes by CellDesigner PMID: 15210709 reaction: direct
fast: false
reversible: false
type: Reaction

298872
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1
type: Species

029479
stoichiometry: 1.0
species: 299838
type: SpeciesReference

022146
stoichiometry: 1.0
species: 299088
type: SpeciesReference

032546
stoichiometry: 1.0
species: 299843
type: SpeciesReference

024302
stoichiometry: 1.0
species: 299213
type: SpeciesReference

299821
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p21Cip*
type: Species

033314
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300595
product: 027823
reactant: 027811
notes: Notes by CellDesigner PMID: 15271987 reaction: direct
fast: false
reversible: false
type: Reaction

299610
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RFC5
type: Species

301113
product: 032366
reactant: 032354
notes: PMID: 17135268
fast: false
reversible: false
type: Reaction

026489
stoichiometry: 1.0
species: 299840
type: SpeciesReference

020773
stoichiometry: 1.0
species: 298928
type: SpeciesReference

022035
stoichiometry: 1.0
species: 299119
type: SpeciesReference

027547
stoichiometry: 1.0
species: 299840
type: SpeciesReference

024686
stoichiometry: 1.0
species: 299272
type: SpeciesReference

026995
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300701
product: 028735
reactant: 028723
notes: Notes by CellDesigner PMID: 11564866 reaction: direct
fast: false
reversible: false
type: Reaction

301265
product: 033782
reactant: 033770
notes: PMID: 16984923
fast: false
reversible: false
type: Reaction

032954
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299394
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM3
type: Species

020148
stoichiometry: 1.0
species: 298835
type: SpeciesReference

025971
stoichiometry: 1.0
species: 299840
type: SpeciesReference

030031
stoichiometry: 1.0
species: 299838
type: SpeciesReference

299248
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MNAT1
type: Species

030649
stoichiometry: 1.0
species: 298923
type: SpeciesReference

031861
stoichiometry: 1.0
species: 299812
type: SpeciesReference

299550
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MAD2L1
type: Species

299427
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDC2
type: Species

030373
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300677
product: 028519
reactant: 028507
notes: PMID: 15510213
fast: false
reversible: false
type: Reaction

299213
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDH1
type: Species

023138
stoichiometry: 1.0
species: 299173
type: SpeciesReference

028603
stoichiometry: 1.0
species: 299843
type: SpeciesReference

021229
stoichiometry: 1.0
species: 298983
type: SpeciesReference

023942
stoichiometry: 1.0
species: 299191
type: SpeciesReference

299289
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: a895_degraded
type: Species

300783
product: 029491
reactant: 029479
notes: PMID: 10030670
fast: false
reversible: false
type: Reaction

300970
product: 030973
reactant: 030961
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

034445
stoichiometry: 1.0
species: 299832
type: SpeciesReference

300020
product: 022035
reactant: 022023
reactant: 022011
notes: (ref REACTOME) PMID: 9106657
fast: false
reversible: false
type: Reaction

299313
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6
type: Species

029539
stoichiometry: 1.0
species: 299503
type: SpeciesReference

298870
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1
type: Species

301337
product: 034519
reactant: 034507
reactant: 034495
notes: p130 binds to and inhibits cyclinE-CDK2, independantly of its phosphorylation state. PMID: 15456871 PMID: 12006580 PMID: 11237530
fast: false
reversible: false
type: Reaction

300741
product: 029119
reactant: 029107
notes: Notes by CellDesigner PMID: 15731768
fast: false
reversible: false
type: Reaction

022609
stoichiometry: 1.0
species: 299086
type: SpeciesReference

021793
stoichiometry: 1.0
species: 299024
type: SpeciesReference

301081
product: 032054
reactant: 032042
notes: Notes by CellDesigner PMID: 16179649
fast: false
reversible: false
type: Reaction

021349
stoichiometry: 1.0
species: 298978
type: SpeciesReference

299501
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DDX11
type: Species

021949
stoichiometry: 1.0
species: 299067
type: SpeciesReference

027583
stoichiometry: 1.0
species: 299369
type: SpeciesReference

300527
product: 027199
reactant: 027187
notes: PMID: 10766737 PMID: 8760872
fast: false
reversible: false
type: Reaction

030489
stoichiometry: 1.0
species: 299364
type: SpeciesReference

031117
stoichiometry: 1.0
species: 299362
type: SpeciesReference

301228
product: 033446
reactant: 033434
fast: false
reversible: false
type: Reaction

027703
stoichiometry: 1.0
species: 299652
type: SpeciesReference

300598
product: 027847
reactant: 027835
notes: Notes by CellDesigner PMID: 12789259 reaction: direct
fast: false
reversible: false
type: Reaction

027175
stoichiometry: 1.0
species: 299389
type: SpeciesReference

033002
stoichiometry: 1.0
species: 298923
type: SpeciesReference

028687
stoichiometry: 1.0
species: 299505
type: SpeciesReference

300566
product: 027559
reactant: 027547
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

020196
stoichiometry: 1.0
species: 298827
type: SpeciesReference

299287
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p53*
type: Species

034632
stoichiometry: 1.0
species: 299475
type: SpeciesReference

021721
stoichiometry: 1.0
species: 299018
type: SpeciesReference

027007
stoichiometry: 1.0
species: 299401
type: SpeciesReference

033170
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299552
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PTGS2
type: Species

301335
product: 034482
reactant: 034470
reactant: 034458
notes: p130 binds to and inhibits cyclinE-CDK2, independantly of its phosphorylation state. PMID: 15456871 PMID: 12006580 PMID: 11237530
fast: false
reversible: false
type: Reaction

300121
product: 023126
reactant: 023114
notes: PMID: 10373560 The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and would need the GTPaseRan/TC4 PMID: 9679058 (ref REACTOME) PMID: 9670027 PMID: 9679058
fast: false
reversible: false
type: Reaction

299246
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin C*
type: Species

032654
stoichiometry: 1.0
species: 299696
type: SpeciesReference

299425
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p21Cip*
type: Species

022183
stoichiometry: 1.0
species: 299088
type: SpeciesReference

024110
stoichiometry: 1.0
species: 299193
type: SpeciesReference

300171
modifier: 023726
product: 023714
reactant: 023702
notes: Phosphorylation of p27 by cyclin E/CDK2 at Thr-187 results in targeting p27 for its degradation by proteolysis PMID: 10385618
fast: false
reversible: false
type: Reaction

299173
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC2/cyclin B1*
type: Species

025707
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299825
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p21Cip*
type: Species

301268
product: 033806
reactant: 033794
notes: PMID: 16984923
fast: false
reversible: false
type: Reaction

301083
product: 032078
reactant: 032066
notes: Notes by CellDesigner PMID: 16179649
fast: false
reversible: false
type: Reaction

299284
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p53*
type: Species

022718
stoichiometry: 1.0
species: 299177
type: SpeciesReference

301332
product: 034445
reactant: 034433
reactant: 034421
notes: p130 binds to and inhibits cyclinA-CDK2, independantly of its phosphorylation state. PMID: 15456871 PMID: 12006580 PMID: 11237530
fast: false
reversible: false
type: Reaction

301196
product: 033158
reactant: 033146
notes: Notes by CellDesigner PMID: 15195143 reaction: direct
fast: false
reversible: false
type: Reaction

300279
product: 025095
reactant: 025083
reactant: 025071
notes: PMID: 12210082 PMID: 10498883
fast: false
reversible: false
type: Reaction

034262
stoichiometry: 1.0
species: 299567
type: SpeciesReference

299398
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCAM
type: Species

026055
stoichiometry: 1.0
species: 299510
type: SpeciesReference

026599
stoichiometry: 1.0
species: 299339
type: SpeciesReference

299594
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PPP1R13B
type: Species

299318
notes: Needs verification: which form of CDC25 gets phosphorylated on Ser216 by Chek1,2???
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC25C
type: Species

034408
stoichiometry: 1.0
species: 299829
type: SpeciesReference

031381
stoichiometry: 1.0
species: 299534
type: SpeciesReference

299423
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDKN2C
type: Species

034684
stoichiometry: 1.0
species: 299578
type: SpeciesReference

299554
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MELK
type: Species

299823
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p21Cip*
type: Species

030673
stoichiometry: 1.0
species: 298923
type: SpeciesReference

026372
stoichiometry: 1.0
species: 299472
type: SpeciesReference

299171
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK7/cyclin H*/MNAT1
type: Species

300569
product: 027583
reactant: 027571
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

033362
stoichiometry: 1.0
species: 299313
type: SpeciesReference

300856
product: 029947
reactant: 029935
notes: Notes by CellDesigner PMID: 12748276 PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

025815
stoichiometry: 1.0
species: 299518
type: SpeciesReference

300025
modifier: 022084
modifier: 022072
product: 022060
reactant: 022048
notes: All three Cip/Kip family members direct the accumulation of cylinD-CDK complexes in the nucleus. PMID: 10385618
fast: false
reversible: false
type: Reaction

299596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PPARG
type: Species

025767
stoichiometry: 1.0
species: 299658
type: SpeciesReference

299880
product: 020220
reactant: 020208
reactant: 020196
notes: Competition between ARF and E2F1 to bind DP1. PMID: 16135794 ARF relocalize DP1 from the cytoplasm to the nucleolus PMID: 12446760
fast: false
reversible: false
type: Reaction

299619
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: HOXA3
type: Species

029431
stoichiometry: 1.0
species: 299838
type: SpeciesReference

299243
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK3
type: Species

300277
product: 025058
reactant: 025046
reactant: 025034
fast: false
reversible: false
type: Reaction

032870
stoichiometry: 1.0
species: 299726
type: SpeciesReference

300066
product: 022513
product: 022501
reactant: 022489
notes: PMID: 10385618 PMID: 10498883
fast: false
reversible: false
type: Reaction

032366
stoichiometry: 1.0
species: 299703
type: SpeciesReference

299658
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ATM
type: Species

299505
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDT1
type: Species

299997
product: 021721
reactant: 021709
reactant: 021697
reactant: 021685
notes: PMID: 15536069 PMID: 15470680
fast: false
reversible: false
type: Reaction

301190
product: 033110
reactant: 033098
notes: PMID: 15706352 PMID: 15731768
fast: false
reversible: false
type: Reaction

301085
product: 032102
reactant: 032090
notes: Notes by CellDesigner PMID: 16179649
fast: false
reversible: false
type: Reaction

020845
stoichiometry: 1.0
species: 298939
type: SpeciesReference

024074
stoichiometry: 1.0
species: 299193
type: SpeciesReference

021877
stoichiometry: 1.0
species: 299065
type: SpeciesReference

025239
stoichiometry: 1.0
species: 299289
type: SpeciesReference

026163
stoichiometry: 1.0
species: 299840
type: SpeciesReference

031453
stoichiometry: 1.0
species: 299689
type: SpeciesReference

301159
product: 032798
reactant: 032786
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

027283
stoichiometry: 1.0
species: 299840
type: SpeciesReference

028759
stoichiometry: 1.0
species: 299339
type: SpeciesReference

033206
stoichiometry: 1.0
species: 299754
type: SpeciesReference

300125
modifier: 023186
product: 023174
reactant: 023162
notes: CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin. PMID: 12814430 WEE1 allows CDC2 to stay in an inactive state after its translocation in late G2 PMID: 10373560 PMID: 8348613 PMID: 9001210 (from REACTOME) PMID: 15037762
fast: false
reversible: false
type: Reaction

023498
stoichiometry: 1.0
species: 299144
type: SpeciesReference

299925
product: 020749
reactant: 020737
reactant: 020725
reactant: 020713
notes: PMID: 15126619 PMID: 15838516 The recruitment of SWI/SNF seems to be necessary for the recrutement de HDAC1 PMID: 11420729 PMID: 15105433
fast: false
reversible: false
type: Reaction

029059
stoichiometry: 1.0
species: 299843
type: SpeciesReference

022826
stoichiometry: 1.0
species: 299162
type: SpeciesReference

300896
product: 030335
reactant: 030323
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

033782
stoichiometry: 1.0
species: 299783
type: SpeciesReference

029107
stoichiometry: 1.0
species: 299843
type: SpeciesReference

021457
stoichiometry: 1.0
species: 299845
type: SpeciesReference

024494
stoichiometry: 1.0
species: 299171
type: SpeciesReference

300237
product: 024542
reactant: 024530
notes: Phosphorylation of p27 at Thr-157 in its NLS, which impair its nuclear import. PMID: 12851486 (from REACTOME) PMID: 9632134
fast: false
reversible: false
type: Reaction

029767
stoichiometry: 1.0
species: 299838
type: SpeciesReference

028015
stoichiometry: 1.0
species: 299585
type: SpeciesReference

033470
stoichiometry: 1.0
species: 299770
type: SpeciesReference

029371
stoichiometry: 1.0
species: 299685
type: SpeciesReference

300854
product: 029923
reactant: 029911
notes: Notes by CellDesigner PMID: 15510213 reaction: direct
fast: false
reversible: false
type: Reaction

025491
stoichiometry: 1.0
species: 298881
type: SpeciesReference

300979
product: 031069
reactant: 031057
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

030601
stoichiometry: 1.0
species: 298923
type: SpeciesReference

027115
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299241
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC14
type: Species

019992
stoichiometry: 1.0
species: 298892
type: SpeciesReference

021397
stoichiometry: 1.0
species: 299040
type: SpeciesReference

300893
product: 030310
reactant: 030298
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

300068
product: 022549
product: 022537
reactant: 022525
fast: false
reversible: false
type: Reaction

033062
stoichiometry: 1.0
species: 299745
type: SpeciesReference

299656
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PBK
type: Species

299598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DHFR
type: Species

026091
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299503
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CNAP1
type: Species

298879
notes: active form
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*
type: Species

024710
stoichiometry: 1.0
species: 298842
type: SpeciesReference

026779
stoichiometry: 1.0
species: 299840
type: SpeciesReference

032618
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300349
product: 025839
reactant: 025827
notes: PMID: 15572025 PMID: 15766563
fast: false
reversible: false
type: Reaction

027475
stoichiometry: 1.0
species: 299840
type: SpeciesReference

025179
stoichiometry: 1.0
species: 299295
type: SpeciesReference

032054
stoichiometry: 1.0
species: 299685
type: SpeciesReference

300524
product: 027175
reactant: 027163
notes: PMID: 8137237 PMID: 10567569
fast: false
reversible: false
type: Reaction

301088
product: 032126
reactant: 032114
notes: Notes by CellDesigner PMID: 16179649 reaction: direct
fast: false
reversible: false
type: Reaction

300123
product: 023150
reactant: 023138
notes: PMID: 10373560 (from REACTOME) PMID: 11063929
fast: false
reversible: false
type: Reaction

299923
product: 020701
reactant: 020689
fast: false
reversible: false
type: Reaction

301193
product: 033134
reactant: 033122
notes: Notes by CellDesigner PMID: 15731768
fast: false
reversible: false
type: Reaction

300028
modifier: 022133
modifier: 022121
product: 022109
reactant: 022097
notes: All three Cip/Kip family members direct the accumulation of cylinD-CDK complexes in the nucleus. PMID: 10385618
fast: false
reversible: false
type: Reaction

299615
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: JPH2
type: Species

032474
stoichiometry: 1.0
species: 299840
type: SpeciesReference

025575
stoichiometry: 1.0
species: 298857
type: SpeciesReference

300391
product: 026223
reactant: 026211
notes: PMID: 10766737
fast: false
reversible: false
type: Reaction

033422
stoichiometry: 1.0
species: 299767
type: SpeciesReference

300128
modifier: 023222
product: 023210
reactant: 023198
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430 (ref REACTOME) PMID: 1828290
fast: false
reversible: false
type: Reaction

020737
stoichiometry: 1.0
species: 298915
type: SpeciesReference

301154
product: 032750
reactant: 032738
notes: PMID: 15105421
fast: false
reversible: false
type: Reaction

300234
product: 024518
reactant: 024506
notes: Proteolysis degradation via the SCF(SKP2) system. PMID: 10385618 PMID: 12814430 PMID: 12851486 Preliminary phosphorylation and cytoplasm export needed for degradation. PMID: 11355576
fast: false
reversible: false
type: Reaction

021769
stoichiometry: 1.0
species: 299027
type: SpeciesReference

024182
stoichiometry: 1.0
species: 299224
type: SpeciesReference

024158
stoichiometry: 1.0
species: 298886
type: SpeciesReference

029323
stoichiometry: 1.0
species: 299430
type: SpeciesReference

298877
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*
type: Species

299067
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6/CDKN2B
type: Species

028375
stoichiometry: 1.0
species: 299371
type: SpeciesReference

299654
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CLSPN
type: Species

031753
stoichiometry: 1.0
species: 298923
type: SpeciesReference

301115
product: 032390
reactant: 032378
notes: PMID: 17471234
fast: false
reversible: false
type: Reaction

299772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ZNF451
type: Species

020256
stoichiometry: 1.0
species: 298894
type: SpeciesReference

300591
product: 027775
reactant: 027763
notes: Notes by CellDesigner PMID: 14633988 reaction: direct
fast: false
reversible: false
type: Reaction

022360
stoichiometry: 1.0
species: 299079
type: SpeciesReference

300859
product: 029971
reactant: 029959
notes: Notes by CellDesigner PMID: 15014447 reaction: direct
fast: false
reversible: false
type: Reaction

021901
stoichiometry: 1.0
species: 299058
type: SpeciesReference

300976
product: 031045
reactant: 031033
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

027439
stoichiometry: 1.0
species: 299481
type: SpeciesReference

300274
modifier: 025022
product: 025010
reactant: 024998
notes: PMID: 12814430 (ref REACTOME) PMID: 12861053
fast: false
reversible: false
type: Reaction

300521
product: 027151
reactant: 027139
notes: PMID: 16144839
fast: false
reversible: false
type: Reaction

301117
product: 032414
reactant: 032402
notes: PMID: 16331253
fast: false
reversible: false
type: Reaction

033926
stoichiometry: 1.0
species: 299786
type: SpeciesReference

034106
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299652
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RPL32
type: Species

300232
product: 024494
reactant: 024482
notes: CDK7 activation by its phosphorylation at Thr-170 PMID: 11355576
fast: false
reversible: false
type: Reaction

300271
modifier: 024986
product: 024974
reactant: 024962
notes: MDM2 phosphorylation by ATM inhibits its interaction with p53 PMID: 15140942 (ref REACTOME) PMID: 11331603 phosphorylation at Ser395
fast: false
reversible: false
type: Reaction

300744
modifier: 029155
product: 029143
reactant: 029131
notes: PMID: 10766737 PMID: 16135806
fast: false
reversible: false
type: Reaction

299507
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDC25A
type: Species

299770
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ZNF83
type: Species

030757
stoichiometry: 1.0
species: 299470
type: SpeciesReference

299928
product: 020773
reactant: 020761
notes: Degradation via the ubiquitin-proteasome system. PMID: 10773440 Degradation via SCF(SKP2) (=SKP1-Culin1-SKP2) PMID: 12717421
fast: false
reversible: false
type: Reaction

299612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: KNTC2
type: Species

023762
stoichiometry: 1.0
species: 299235
type: SpeciesReference

300593
product: 027799
reactant: 027787
notes: Notes by CellDesigner PMID: 14633988 reaction: direct
fast: false
reversible: false
type: Reaction

024518
stoichiometry: 1.0
species: 299257
type: SpeciesReference

299992
product: 021673
reactant: 021661
reactant: 021649
notes: PMID: 12004135 PMID: 15536069 PMID: 15126619
fast: false
reversible: false
type: Reaction

301157
product: 032774
reactant: 032762
fast: false
reversible: false
type: Reaction

030335
stoichiometry: 1.0
species: 299435
type: SpeciesReference

300974
product: 031021
reactant: 031009
notes: Notes by CellDesigner PMID: 14990995 reaction: direct
fast: false
reversible: false
type: Reaction

028063
stoichiometry: 1.0
species: 299556
type: SpeciesReference

028795
stoichiometry: 1.0
species: 299843
type: SpeciesReference

024794
stoichiometry: 1.0
species: 299284
type: SpeciesReference

298874
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*
type: Species

020412
stoichiometry: 1.0
species: 298872
type: SpeciesReference

031417
stoichiometry: 1.0
species: 298923
type: SpeciesReference

301221
product: 033398
reactant: 033386
notes: Notes by CellDesigner PMID: 10733529 PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

300922
product: 030589
reactant: 030577
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

031345
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300343
product: 025791
reactant: 025779
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

021001
stoichiometry: 1.0
species: 298906
type: SpeciesReference

299877
product: 020184
reactant: 020172
reactant: 020160
notes: Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair. PMID: 15838517 PMID: 12697828
fast: false
reversible: false
type: Reaction

020088
stoichiometry: 1.0
species: 298870
type: SpeciesReference

300282
modifier: 025143
modifier: 025131
product: 025119
reactant: 025107
notes: Inactivated by phosphorylation by CHEK1 and CHEK2 PMID: 12478465 PMID: 12814430 (ref REACTOME) PMID: 9278512 PMID: 9836640 PMID: 9889122 Phosphorylation by CyclinB-CDC2 PMID: 11313986 ? => concerns CDC25A
fast: false
reversible: false
type: Reaction

301012
product: 031381
reactant: 031369
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

300637
product: 028159
reactant: 028147
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

023066
stoichiometry: 1.0
species: 299173
type: SpeciesReference

299663
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F7
type: Species

301163
product: 032846
reactant: 032834
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

022645
stoichiometry: 1.0
species: 298967
type: SpeciesReference

032570
stoichiometry: 1.0
species: 299838
type: SpeciesReference

026839
stoichiometry: 1.0
species: 299468
type: SpeciesReference

027859
stoichiometry: 1.0
species: 299309
type: SpeciesReference

299024
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: RYBP/RING1/MEL-18*/_br_PHC1/BMI1*/E2F6/DP2*
type: Species

026731
stoichiometry: 1.0
species: 299840
type: SpeciesReference

034569
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299763
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TRIM55
type: Species

032198
stoichiometry: 1.0
species: 299843
type: SpeciesReference

029263
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300933
product: 030637
reactant: 030625
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

299063
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4/p16INK4a*
type: Species

300383
product: 026151
reactant: 026139
notes: PMID: 12611887
fast: false
reversible: false
type: Reaction

027055
stoichiometry: 1.0
species: 299396
type: SpeciesReference

299761
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TUBA3
type: Species

033806
stoichiometry: 1.0
species: 299783
type: SpeciesReference

028975
stoichiometry: 1.0
species: 299462
type: SpeciesReference

300071
product: 022585
product: 022573
reactant: 022561
fast: false
reversible: false
type: Reaction

299875
product: 020148
reactant: 020136
fast: false
reversible: false
type: Reaction

024278
stoichiometry: 1.0
species: 298805
type: SpeciesReference

029983
stoichiometry: 1.0
species: 299838
type: SpeciesReference

033674
stoichiometry: 1.0
species: 299313
type: SpeciesReference

026223
stoichiometry: 1.0
species: 299556
type: SpeciesReference

299661
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F Family
type: Species

031237
stoichiometry: 1.0
species: 299683
type: SpeciesReference

021169
stoichiometry: 1.0
species: 298956
type: SpeciesReference

030260
stoichiometry: 1.0
species: 299512
type: SpeciesReference

029575
stoichiometry: 1.0
species: 299838
type: SpeciesReference

034154
stoichiometry: 1.0
species: 299838
type: SpeciesReference

029611
stoichiometry: 1.0
species: 299416
type: SpeciesReference

299022
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/EPC1/Sin3B/EZH2/DP1*/EED
type: Species

029839
stoichiometry: 1.0
species: 299838
type: SpeciesReference

024566
stoichiometry: 1.0
species: 299825
type: SpeciesReference

300340
product: 025767
reactant: 025755
notes: PMID: 12527885
fast: false
reversible: false
type: Reaction

300931
product: 030613
reactant: 030601
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

022585
stoichiometry: 1.0
species: 299044
type: SpeciesReference

299065
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6/p16INK4a*
type: Species

021565
stoichiometry: 1.0
species: 299035
type: SpeciesReference

031537
stoichiometry: 1.0
species: 298923
type: SpeciesReference

025983
stoichiometry: 1.0
species: 299604
type: SpeciesReference

028159
stoichiometry: 1.0
species: 299501
type: SpeciesReference

030925
stoichiometry: 1.0
species: 299494
type: SpeciesReference

299479
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F8
type: Species

032258
stoichiometry: 1.0
species: 299840
type: SpeciesReference

028567
stoichiometry: 1.0
species: 299430
type: SpeciesReference

020521
stoichiometry: 1.0
species: 298949
type: SpeciesReference

298939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p130*/E2F4/DP2*
type: Species

031969
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300381
product: 026127
reactant: 026115
notes: PMID: 15510213
fast: false
reversible: false
type: Reaction

301016
product: 031429
reactant: 031417
notes: Notes by CellDesigner PMID: 11564866 PMID: 12150994 reaction: direct
fast: false
reversible: false
type: Reaction

025719
stoichiometry: 1.0
species: 299448
type: SpeciesReference

034190
stoichiometry: 1.0
species: 299479
type: SpeciesReference

027259
stoichiometry: 1.0
species: 299840
type: SpeciesReference

023174
stoichiometry: 1.0
species: 299164
type: SpeciesReference

025203
stoichiometry: 1.0
species: 298894
type: SpeciesReference

299728
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SOAT2
type: Species

026335
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299767
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: WWOX
type: Species

020304
stoichiometry: 1.0
species: 298883
type: SpeciesReference

025695
stoichiometry: 1.0
species: 299451
type: SpeciesReference

299962
modifier: 021313
modifier: 021289
product: 021265
notes: Phosphorylation of pRB PMID: 9315635 dissociation of HDAC1 (during the G1 to S transition) PMID: 10778858 PMID: 11520855 PMID: 7736585, PMID: 9425340 weinberg CycD phosphorylates RB (ref REACTOME) PMID: 9190208
modifier: 021277
type: Reaction
product: 021253
fast: false
reversible: false
modifier: 021301
reactant: 021241

020881
stoichiometry: 1.0
species: 298908
type: SpeciesReference

030223
stoichiometry: 1.0
species: 298923
type: SpeciesReference

027019
stoichiometry: 1.0
species: 299840
type: SpeciesReference

028807
stoichiometry: 1.0
species: 299641
type: SpeciesReference

028411
stoichiometry: 1.0
species: 299313
type: SpeciesReference

030973
stoichiometry: 1.0
species: 299623
type: SpeciesReference

300074
product: 022609
reactant: 022597
notes: degradation of cyclin D via the ubiquitin-proteasome system PMID: 9736735
fast: false
reversible: false
type: Reaction

023270
stoichiometry: 1.0
species: 299180
type: SpeciesReference

026127
stoichiometry: 1.0
species: 299559
type: SpeciesReference

030565
stoichiometry: 1.0
species: 299505
type: SpeciesReference

300891
product: 030285
reactant: 030273
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

299499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DNMT1
type: Species

021987
stoichiometry: 1.0
species: 299063
type: SpeciesReference

025275
stoichiometry: 1.0
species: 299794
type: SpeciesReference

020376
stoichiometry: 1.0
species: 298863
type: SpeciesReference

300404
product: 026322
reactant: 026310
notes: PMID: 14990995
fast: false
reversible: false
type: Reaction

299872
product: 020124
reactant: 020112
fast: false
reversible: false
type: Reaction

031573
stoichiometry: 1.0
species: 299378
type: SpeciesReference

033254
stoichiometry: 1.0
species: 299759
type: SpeciesReference

299477
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F4 cofactors
type: Species

027967
stoichiometry: 1.0
species: 299435
type: SpeciesReference

031681
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299726
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SNX19
type: Species

300239
product: 024578
reactant: 024566
reactant: 024554
notes: Inhibition of PCNA by p21. PMID: 12814430
fast: false
reversible: false
type: Reaction

301014
product: 031405
reactant: 031393
notes: Notes by CellDesigner PMID: 10766737 PMID: 8760872 reaction: direct
fast: false
reversible: false
type: Reaction

299132
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC2
type: Species

026947
stoichiometry: 1.0
species: 299840
type: SpeciesReference

298793
constant: true
size: NaN
spatial dimensions: 3.0
name: nucleus
type: Compartment

025419
stoichiometry: 1.0
species: 299182
type: SpeciesReference

300345
product: 025815
reactant: 025803
notes: PMID: 15033491
fast: false
reversible: false
type: Reaction

026887
stoichiometry: 1.0
species: 299410
type: SpeciesReference

024938
stoichiometry: 1.0
species: 299298
type: SpeciesReference

299060
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4/CDKN2B
type: Species

299765
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TYMS
type: Species

032990
stoichiometry: 1.0
species: 299741
type: SpeciesReference

301161
product: 032822
reactant: 032810
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

033566
stoichiometry: 1.0
species: 299774
type: SpeciesReference

021625
stoichiometry: 1.0
species: 298976
type: SpeciesReference

300639
product: 028183
reactant: 028171
notes: Notes by CellDesigner PMID: 12004135 reaction: direct
fast: false
reversible: false
type: Reaction

031813
stoichiometry: 1.0
species: 299371
type: SpeciesReference

299475
notes: Needs verification: which form of CDC25 gets phosphorylated on Ser216 by Chek1,2???
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F6 cofactors
type: Species

032906
stoichiometry: 1.0
species: 298923
type: SpeciesReference

025383
stoichiometry: 1.0
species: 298994
type: SpeciesReference

299920
product: 020677
reactant: 020665
notes: relatively low nuclear levels of E2F4 is maintained by efficient CRM1-dependent nuclear export. PMID: 11158323 E2F-5 is exported from the nucleus through leptomycin B-sensitive, CRM1-mediated transport, through a region corresponding to amino acid residues 130-154. PMID: 12089160
fast: false
reversible: false
type: Reaction

020484
stoichiometry: 1.0
species: 298935
type: SpeciesReference

024410
stoichiometry: 1.0
species: 299093
type: SpeciesReference

025359
stoichiometry: 1.0
species: 299005
type: SpeciesReference

027643
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300076
product: 022645
reactant: 022633
reactant: 022621
notes: PMID: 16775416
fast: false
reversible: false
type: Reaction

300385
product: 026175
reactant: 026163
notes: PMID: 8618861
fast: false
reversible: false
type: Reaction

032150
stoichiometry: 1.0
species: 299661
type: SpeciesReference

022426
stoichiometry: 1.0
species: 299113
type: SpeciesReference

300163
modifier: 023618
product: 023606
reactant: 023594
notes: Inactivated by phosphorylation by CHEK1 and CHEK2 PMID: 12478465 PMID: 12814430 Phosphorylation by CyclinB-CDC2 PMID: 11313986 ? => concerns CDC25A
fast: false
reversible: false
type: Reaction

299829
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2/p107
type: Species

027919
stoichiometry: 1.0
species: 299483
type: SpeciesReference

029083
stoichiometry: 1.0
species: 299843
type: SpeciesReference

299177
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC2/cyclin B1*
type: Species

024974
stoichiometry: 1.0
species: 299792
type: SpeciesReference

299966
modifier: 021361
product: 021349
product: 021337
reactant: 021325
notes: pRB phosphorylation PMID: 9315635 PMID: 12006580 Brg1 phosphorylation PMID: 11420722 Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB PMID: 9315635 PMID: 12006580 Phosphorylation of Brg1 (SWI/SNF complex) PMID: 11420722
fast: false
reversible: false
type: Reaction

299494
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: EXOSC8
type: Species

030865
stoichiometry: 1.0
species: 298923
type: SpeciesReference

031645
stoichiometry: 1.0
species: 299650
type: SpeciesReference

022465
stoichiometry: 1.0
species: 299075
type: SpeciesReference

299472
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CHEK2
type: Species

026695
stoichiometry: 1.0
species: 299416
type: SpeciesReference

033734
stoichiometry: 1.0
species: 299780
type: SpeciesReference

032726
stoichiometry: 1.0
species: 299701
type: SpeciesReference

033146
stoichiometry: 1.0
species: 298923
type: SpeciesReference

023090
stoichiometry: 1.0
species: 299175
type: SpeciesReference

300788
product: 029539
reactant: 029527
notes: Notes by CellDesigner PMID: 16144839
fast: false
reversible: false
type: Reaction

299137
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: PKMYT1
type: Species

298933
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p107*/E2F4/DP2*
type: Species

299543
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MLH1
type: Species

299432
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: cyclin A2*
type: Species

298971
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4/CDKN1A
type: Species

020040
stoichiometry: 1.0
species: 298877
type: SpeciesReference

300562
product: 027511
reactant: 027499
notes: PMID: 15867358
fast: false
reversible: false
type: Reaction

299282
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p53*
type: Species

030709
stoichiometry: 1.0
species: 299501
type: SpeciesReference

027811
stoichiometry: 1.0
species: 299309
type: SpeciesReference

300447
product: 026695
reactant: 026683
notes: PMID: 14532106
fast: false
reversible: false
type: Reaction

299320
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: WEE1
type: Species

301018
product: 031453
reactant: 031441
notes: Notes by CellDesigner PMID: 12438307 reaction: direct
fast: false
reversible: false
type: Reaction

025647
stoichiometry: 1.0
species: 299330
type: SpeciesReference

033626
stoichiometry: 1.0
species: 299843
type: SpeciesReference

300388
product: 026199
reactant: 026187
notes: PMID: 15510213
fast: false
reversible: false
type: Reaction

032090
stoichiometry: 1.0
species: 299311
type: SpeciesReference

028111
stoichiometry: 1.0
species: 299472
type: SpeciesReference

299175
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin B1*/CDC2
type: Species

026019
stoichiometry: 1.0
species: 299840
type: SpeciesReference

031273
stoichiometry: 1.0
species: 298923
type: SpeciesReference

301270
product: 033830
reactant: 033818
notes: PMID: 16984923
fast: false
reversible: false
type: Reaction

299496
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: EIF2AK2
type: Species

298974
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: PP1
type: Species

299209
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a38_degraded
type: Species

031921
stoichiometry: 1.0
species: 298923
type: SpeciesReference

032210
stoichiometry: 1.0
species: 299661
type: SpeciesReference

299470
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DIRAS3
type: Species

028915
stoichiometry: 1.0
species: 299843
type: SpeciesReference

029659
stoichiometry: 1.0
species: 299486
type: SpeciesReference

030115
stoichiometry: 1.0
species: 299639
type: SpeciesReference

298931
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
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type: Species

023870
stoichiometry: 1.0
species: 299200
type: SpeciesReference

021517
stoichiometry: 1.0
species: 299038
type: SpeciesReference

023234
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species: 299180
type: SpeciesReference

299430
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CCND3
type: Species

031309
stoichiometry: 1.0
species: 299543
type: SpeciesReference

300670
product: 028447
reactant: 028435
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

021121
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species: 298989
type: SpeciesReference

300406
product: 026347
reactant: 026335
fast: false
reversible: false
type: Reaction

024230
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species: 299237
type: SpeciesReference

299545
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: METAP2
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299280
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
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name: NBS1
type: Species

034082
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300445
product: 026671
reactant: 026659
notes: PMID: 14633988
fast: false
reversible: false
type: Reaction

022282
stoichiometry: 1.0
species: 299091
type: SpeciesReference

299135
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: PKMYT1
type: Species

300564
product: 027535
reactant: 027523
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

301272
product: 033854
reactant: 033842
notes: PMID: 16580749
fast: false
reversible: false
type: Reaction

032834
stoichiometry: 1.0
species: 298923
type: SpeciesReference

027799
stoichiometry: 1.0
species: 299339
type: SpeciesReference

033842
stoichiometry: 1.0
species: 298923
type: SpeciesReference

019884
stoichiometry: 1.0
species: 298877
type: SpeciesReference

299548
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM5
type: Species

023438
stoichiometry: 1.0
species: 299164
type: SpeciesReference

025875
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299391
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM10
type: Species

299720
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SLC25A14
type: Species

299490
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FHIT
type: Species

300785
product: 029515
reactant: 029503
notes: Notes by CellDesigner PMID: 14990995
fast: false
reversible: false
type: Reaction

028459
stoichiometry: 1.0
species: 299843
type: SpeciesReference

299207
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*
type: Species

029947
stoichiometry: 1.0
species: 299650
type: SpeciesReference

024038
stoichiometry: 1.0
species: 299088
type: SpeciesReference

298976
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: HP1gamma*
type: Species

034046
stoichiometry: 1.0
species: 299810
type: SpeciesReference

300672
product: 028471
reactant: 028459
notes: Notes by CellDesigner PMID: 11559537
fast: false
reversible: false
type: Reaction

298937
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p130*/E2F4/DP2*
type: Species

028867
stoichiometry: 1.0
species: 299843
type: SpeciesReference

031609
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300166
modifier: 023654
product: 023642
reactant: 023630
notes: CDK activity stimulated by its CAK-complex phosphorylation. PMID: 12459251 PMID: 12814430 (ref REACTOME) PMID: 7629134
fast: false
reversible: false
type: Reaction

027211
stoichiometry: 1.0
species: 299840
type: SpeciesReference

022537
stoichiometry: 1.0
species: 299084
type: SpeciesReference

032426
stoichiometry: 1.0
species: 299840
type: SpeciesReference

MODEL4132046015
species: 299650
species: 299309
reaction: 299880
reaction: 301256
reaction: 300510
species: 298851
reaction: 301340
reaction: 300044
species: 298937
reaction: 301261
reaction: 299948
species: 299745
species: 299678
reaction: 300741
reaction: 301138
species: 299587
species: 299077
reaction: 300312
reaction: 300732
reaction: 301224
species: 299175
reaction: 300578
species: 299681
species: 299000
species: 299808
reaction: 301154
reaction: 300371
species: 299230
reaction: 300725
reaction: 300562
species: 299157
reaction: 301215
reaction: 300140
reaction: 301208
reaction: 300133
reaction: 300012
species: 299832
reaction: 301045
reaction: 300425
species: 299741
species: 299534
reaction: 299884
reaction: 300618
reaction: 300616
reaction: 300094
reaction: 300364
reaction: 299893
reaction: 301106
species: 299031
species: 299171
species: 299726
reaction: 301199
species: 298861
reaction: 301016
reaction: 301007
reaction: 300546
reaction: 300539
species: 298967
species: 299300
species: 299332
species: 299259
reaction: 301281
reaction: 300418
species: 299472
reaction: 300255
reaction: 299877
species: 299108
reaction: 300623
species: 299188
reaction: 301122
reaction: 301115
species: 298974
species: 299761
species: 299027
species: 299608
species: 299013
species: 299527
reaction: 301023
reaction: 300309
reaction: 300854

026260
stoichiometry: 1.0
species: 299840
type: SpeciesReference

029875
stoichiometry: 1.0
species: 299384
type: SpeciesReference

024614
stoichiometry: 1.0
species: 299270
type: SpeciesReference

300499
product: 026959
reactant: 026947
notes: PMID: 15464731
fast: false
reversible: false
type: Reaction

022934
stoichiometry: 1.0
species: 299173
type: SpeciesReference

299029
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP2*
type: Species

298835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: DP1*
type: Species

020677
stoichiometry: 1.0
species: 298921
type: SpeciesReference

030502
stoichiometry: 1.0
species: 298923
type: SpeciesReference

030151
stoichiometry: 1.0
species: 298923
type: SpeciesReference

032102
stoichiometry: 1.0
species: 299339
type: SpeciesReference

300169
modifier: 023690
product: 023678
reactant: 023666
notes: PMID: 10385618 PMID: 12459251
fast: false
reversible: false
type: Reaction

030817
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300409
product: 026372
reactant: 026360
notes: PMID: 15706352 PMID: 12909625
fast: false
reversible: false
type: Reaction

301274
product: 033878
reactant: 033866
notes: PMID: 16580749
fast: false
reversible: false
type: Reaction

025923
stoichiometry: 1.0
species: 299840
type: SpeciesReference

032762
stoichiometry: 1.0
species: 298923
type: SpeciesReference

021673
stoichiometry: 1.0
species: 299035
type: SpeciesReference

028267
stoichiometry: 1.0
species: 299313
type: SpeciesReference

298978
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SWI/SNF
type: Species

024458
stoichiometry: 1.0
species: 298965
type: SpeciesReference

299492
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FGFR2
type: Species

024506
stoichiometry: 1.0
species: 299219
type: SpeciesReference

022694
stoichiometry: 1.0
species: 299135
type: SpeciesReference

029683
stoichiometry: 1.0
species: 299410
type: SpeciesReference

029215
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300674
product: 028495
reactant: 028483
notes: Notes by CellDesigner PMID: 15271987
fast: false
reversible: false
type: Reaction

298935
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: Sin3B/HDAC1
type: Species

299139
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC20
type: Species

030067
stoichiometry: 1.0
species: 299647
type: SpeciesReference

299322
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p53*
type: Species

032006
stoichiometry: 1.0
species: 299432
type: SpeciesReference

031057
stoichiometry: 1.0
species: 298923
type: SpeciesReference

024386
stoichiometry: 1.0
species: 299248
type: SpeciesReference

026502
stoichiometry: 1.0
species: 299501
type: SpeciesReference

299204
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*
type: Species

299027
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: RYBP/RING1/BMI1*/_br_MEL-18*/PHC1
type: Species

027367
stoichiometry: 1.0
species: 299572
type: SpeciesReference

300770
product: 029371
reactant: 029359
notes: Notes by CellDesigner PMID: 15014447 reaction: direct
fast: false
reversible: false
type: Reaction

027559
stoichiometry: 1.0
species: 299371
type: SpeciesReference

026983
stoichiometry: 1.0
species: 299403
type: SpeciesReference

300983
product: 031093
reactant: 031081
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

299237
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: APC
type: Species

301188
product: 033086
reactant: 033074
notes: Notes by CellDesigner PMID: 15731768
fast: false
reversible: false
type: Reaction

299224
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2
type: Species

300889
product: 030260
reactant: 030248
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

020785
stoichiometry: 1.0
species: 298919
type: SpeciesReference

028219
stoichiometry: 1.0
species: 299313
type: SpeciesReference

020136
stoichiometry: 1.0
species: 298824
type: SpeciesReference

032966
stoichiometry: 1.0
species: 299738
type: SpeciesReference

299119
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6/cyclin D1*
type: Species

024674
stoichiometry: 1.0
species: 299823
type: SpeciesReference

301277
product: 033902
reactant: 033890
notes: PMID: 16580749
fast: false
reversible: false
type: Reaction

300031
product: 022170
reactant: 022158
reactant: 022146
notes: The complex cyclinD-CDK stability increases when bound to a Cip/Kip family member. PMID: 10385618
fast: false
reversible: false
type: Reaction

025515
stoichiometry: 1.0
species: 298888
type: SpeciesReference

299959
product: 021229
product: 021217
reactant: 021205
notes: Once the process of methylation has started, pRB is detached from the DNA. PMID: 15126619 OR phosphorylation of RB destroy its binding with SUV39H1 PMID: 11533237
fast: false
reversible: false
type: Reaction

023126
stoichiometry: 1.0
species: 299175
type: SpeciesReference

023930
stoichiometry: 1.0
species: 299202
type: SpeciesReference

026437
stoichiometry: 1.0
species: 299840
type: SpeciesReference

301124
product: 032486
reactant: 032474
notes: PMID: 15590326
fast: false
reversible: false
type: Reaction

031873
stoichiometry: 1.0
species: 298923
type: SpeciesReference

030385
stoichiometry: 1.0
species: 299559
type: SpeciesReference

300665
product: 028423
reactant: 028411
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

023390
stoichiometry: 1.0
species: 299177
type: SpeciesReference

022048
stoichiometry: 1.0
species: 299117
type: SpeciesReference

299439
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BCL2L11
type: Species

301349
product: 034645
reactant: 034632
fast: false
reversible: false
type: Reaction

301237
product: 033542
reactant: 033530
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

033098
stoichiometry: 1.0
species: 299840
type: SpeciesReference

030199
stoichiometry: 1.0
species: 298923
type: SpeciesReference

029527
stoichiometry: 1.0
species: 299838
type: SpeciesReference

023642
stoichiometry: 1.0
species: 298960
type: SpeciesReference

300450
product: 026719
reactant: 026707
notes: PMID: 16275992 PMID: 12214268
fast: false
reversible: false
type: Reaction

299278
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: NBS1
type: Species

300519
product: 027127
reactant: 027115
notes: PMID: 15195143
fast: false
reversible: false
type: Reaction

023462
stoichiometry: 1.0
species: 299139
type: SpeciesReference

298861
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: sa376_degraded
type: Species

031489
stoichiometry: 1.0
species: 298923
type: SpeciesReference

033950
stoichiometry: 1.0
species: 299788
type: SpeciesReference

301186
product: 033062
reactant: 033050
notes: PMID: 15706352
fast: false
reversible: false
type: Reaction

299226
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2
type: Species

299832
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2/p130
type: Species

299384
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: NPAT
type: Species

029731
stoichiometry: 1.0
species: 299360
type: SpeciesReference

034458
stoichiometry: 1.0
species: 298960
type: SpeciesReference

019836
stoichiometry: 1.0
species: 298857
type: SpeciesReference

026611
stoichiometry: 1.0
species: 299840
type: SpeciesReference

031909
stoichiometry: 1.0
species: 299608
type: SpeciesReference

300985
product: 031117
reactant: 031105
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

028315
stoichiometry: 1.0
species: 299313
type: SpeciesReference

301122
product: 032462
reactant: 032450
notes: PMID: 11937641 PMID: 15210709
fast: false
reversible: false
type: Reaction

023534
stoichiometry: 1.0
species: 299168
type: SpeciesReference

028471
stoichiometry: 1.0
species: 299574
type: SpeciesReference

034519
stoichiometry: 1.0
species: 299834
type: SpeciesReference

025731
stoichiometry: 1.0
species: 299840
type: SpeciesReference

301235
product: 033518
reactant: 033506
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

033326
stoichiometry: 1.0
species: 299763
type: SpeciesReference

300663
product: 028399
reactant: 028387
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

022158
stoichiometry: 1.0
species: 299097
type: SpeciesReference

027751
stoichiometry: 1.0
species: 299685
type: SpeciesReference

031165
stoichiometry: 1.0
species: 299394
type: SpeciesReference

027895
stoichiometry: 1.0
species: 299410
type: SpeciesReference

032534
stoichiometry: 1.0
species: 299705
type: SpeciesReference

300452
product: 026743
reactant: 026731
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

300517
product: 027103
reactant: 027091
notes: PMID: 14990995
fast: false
reversible: false
type: Reaction

301344
product: 034594
reactant: 034582
fast: false
reversible: false
type: Reaction

023798
stoichiometry: 1.0
species: 299230
type: SpeciesReference

299272
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2/CDKN1A
type: Species

301184
product: 033038
reactant: 033026
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

026067
stoichiometry: 1.0
species: 299840
type: SpeciesReference

026587
stoichiometry: 1.0
species: 299840
type: SpeciesReference

020448
stoichiometry: 1.0
species: 298937
type: SpeciesReference

034250
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299834
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2/p130
type: Species

022754
stoichiometry: 1.0
species: 299168
type: SpeciesReference

299386
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MXD3
type: Species

299233
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2/cyclin E1*
type: Species

299435
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CBX5
type: Species

021493
stoichiometry: 1.0
species: 299007
type: SpeciesReference

025010
stoichiometry: 1.0
species: 299280
type: SpeciesReference

301120
product: 032438
reactant: 032426
notes: PMID: 12368233
fast: false
reversible: false
type: Reaction

301072
product: 031982
reactant: 031969
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

031393
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F8 cofactors
type: Species

300454
product: 026767
reactant: 026755
notes: PMID: 14532106
fast: false
reversible: false
type: Reaction

033374
stoichiometry: 1.0
species: 299765
type: SpeciesReference

300557
product: 027487
reactant: 027475
notes: PMID: 15706352 PMID: 15731768
fast: false
reversible: false
type: Reaction

030721
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299221
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p27Kip1*
type: Species

030661
stoichiometry: 1.0
species: 299630
type: SpeciesReference

026360
stoichiometry: 1.0
species: 299840
type: SpeciesReference

021937
stoichiometry: 1.0
species: 299058
type: SpeciesReference

034671
stoichiometry: 1.0
species: 299309
type: SpeciesReference

299235
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2/cyclin E1*/CDKN1B
type: Species

027595
stoichiometry: 1.0
species: 299843
type: SpeciesReference

029191
stoichiometry: 1.0
species: 299838
type: SpeciesReference

031129
stoichiometry: 1.0
species: 298923
type: SpeciesReference

021337
stoichiometry: 1.0
species: 298883
type: SpeciesReference

028675
stoichiometry: 1.0
species: 299843
type: SpeciesReference

020184
stoichiometry: 1.0
species: 298901
type: SpeciesReference

299162
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2
type: Species

020028
stoichiometry: 1.0
species: 298824
type: SpeciesReference

027715
stoichiometry: 1.0
species: 299840
type: SpeciesReference

021073
stoichiometry: 1.0
species: 298810
type: SpeciesReference

299836
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2/p107
type: Species

027163
stoichiometry: 1.0
species: 299840
type: SpeciesReference

027403
stoichiometry: 1.0
species: 299840
type: SpeciesReference

032642
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300514
product: 027079
reactant: 027067
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

301070
product: 031957
reactant: 031945
notes: Notes by CellDesigner PMID: 14688249 reaction: direct
fast: false
reversible: false
type: Reaction

032138
stoichiometry: 1.0
species: 298863
type: SpeciesReference

299275
notes: UNIPROT: Q13315 O00631 Q14964 Q8TDS3 Q8NG43 Q6TZ07 Q8NG45 Q8NG44 Q6TZ08 Q8NG42 Q8TDS2 Q5XKH5 Q6P7P1 Q8TDS0 Q96QM9 Q68DE6 Q7KYL7 Q8TDS1 O95727 Q6IRX2 Q9UPF7 P06401 Q12758 Q9NP02 Q9UCX7 Q13315 O15429 Q16551 Q93007 Q9BZC6 Q93034 O14766
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: ATM
type: Species

020701
stoichiometry: 1.0
species: 298919
type: SpeciesReference

298942
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F4/DP2*
type: Species

300034
product: 022207
reactant: 022195
reactant: 022183
notes: The complex cyclinD-CDK stability increases when bound to a Cip/Kip family member. PMID: 10385618
fast: false
reversible: false
type: Reaction

300555
product: 027463
reactant: 027451
notes: PMID: 15711575 PMID: 12110166
fast: false
reversible: false
type: Reaction

022195
stoichiometry: 1.0
species: 299091
type: SpeciesReference

301239
product: 033566
reactant: 033554
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

301347
product: 034619
reactant: 034607
fast: false
reversible: false
type: Reaction

027103
stoichiometry: 1.0
species: 299683
type: SpeciesReference

028639
stoichiometry: 1.0
species: 299556
type: SpeciesReference

029383
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300224
product: 024398
reactant: 024386
reactant: 024374
reactant: 024362
fast: false
reversible: false
type: Reaction

033482
stoichiometry: 1.0
species: 298923
type: SpeciesReference

030613
stoichiometry: 1.0
species: 299472
type: SpeciesReference

300039
product: 022269
reactant: 022257
notes: PMID: 12459251 PMID: 10385618 T286 phosphorylation promote association of cyclin D1 with its nuclear exporter CRM1, leading to cytoplasmic translocation of cylcin D1 PMID: 12851486
fast: false
reversible: false
type: Reaction

025455
stoichiometry: 1.0
species: 299320
type: SpeciesReference

301340
product: 034544
reactant: 034532
fast: false
reversible: false
type: Reaction

033518
stoichiometry: 1.0
species: 299772
type: SpeciesReference

021385
stoichiometry: 1.0
species: 298919
type: SpeciesReference

301230
product: 033470
reactant: 033458
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

033050
stoichiometry: 1.0
species: 299840
type: SpeciesReference

301075
product: 032006
reactant: 031994
notes: PMID: 16179649
fast: false
reversible: false
type: Reaction

299717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SLC3A2
type: Species

299699
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p27Kip*
type: Species

300882
product: 030187
reactant: 030175
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

032606
stoichiometry: 1.0
species: 299699
type: SpeciesReference

299604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CASP3
type: Species

026767
stoichiometry: 1.0
species: 299412
type: SpeciesReference

299585
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CCNB2
type: Species

301300
product: 034118
reactant: 034106
notes: PMID: 16179649
fast: false
reversible: false
type: Reaction

299645
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SERPINE1
type: Species

300938
product: 030685
reactant: 030673
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

301181
product: 033014
reactant: 033002
notes: Notes by CellDesigner PMID: 12446714 reaction: direct
fast: false
reversible: false
type: Reaction

299799
notes: ATR phosphorylate Ser-317 and Ser-345
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CHEK1
type: Species

299389
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MYB
type: Species

300264
modifier: 024902
product: 024890
reactant: 024878
notes: PMID: 15024084 Phosphorylation by ATR at Ser-317 et Ser-345 (ref REACTOME) PMID: 15190204 PMID: 10859163 PMID: 11090622 PMID: 11390642 PMID: 15279789 PMID: 12781359 PMID: 15272308 PMID: 12766152 PMID: 16431910 PMID: 10859164 PMID: 16360315
fast: false
reversible: false
type: Reaction

025167
stoichiometry: 1.0
species: 299302
type: SpeciesReference

032066
stoichiometry: 1.0
species: 299311
type: SpeciesReference

300079
product: 022682
reactant: 022670
reactant: 022657
notes: 12836612
fast: false
reversible: false
type: Reaction

300512
product: 027055
reactant: 027043
notes: PMID: 11857079
fast: false
reversible: false
type: Reaction

027487
stoichiometry: 1.0
species: 299594
type: SpeciesReference

300737
product: 029071
reactant: 029059
notes: Notes by CellDesigner PMID: 11883935
fast: false
reversible: false
type: Reaction

027511
stoichiometry: 1.0
species: 299552
type: SpeciesReference

300338
product: 025743
reactant: 025731
notes: PMID: 12015319
fast: false
reversible: false
type: Reaction

029443
stoichiometry: 1.0
species: 299364
type: SpeciesReference

025803
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300037
modifier: 022244
product: 022232
reactant: 022220
notes: PMID: 12459251 PMID: 10385618 (ref REACTOME) PMID: 16732330
fast: false
reversible: false
type: Reaction

025779
stoichiometry: 1.0
species: 299840
type: SpeciesReference

032354
stoichiometry: 1.0
species: 299838
type: SpeciesReference

024086
stoichiometry: 1.0
species: 299204
type: SpeciesReference

020857
stoichiometry: 1.0
species: 298935
type: SpeciesReference

021865
stoichiometry: 1.0
species: 299051
type: SpeciesReference

299696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FOXO3a
type: Species

299914
type: Reaction
fast: false
reactant: 020533
modifier: 020605
modifier: 020569
reversible: false
notes: PMID: 12006580
modifier: 020581
modifier: 020593
product: 020545
modifier: 020557

300112
modifier: 023042
product: 023030
reactant: 023018
notes: Phosphorylation only when CDC2 is bound to the cyclin B PMID: 10373560 PMID: 9001210 PMID: 12814430 (ref REACTOME) PMID: 9268380
fast: false
reversible: false
type: Reaction

301342
product: 034569
reactant: 034557
fast: false
reversible: false
type: Reaction

300884
product: 030211
reactant: 030199
notes: Notes by CellDesigner PMID: 11559537
fast: false
reversible: false
type: Reaction

022982
stoichiometry: 1.0
species: 299177
type: SpeciesReference

300510
product: 027031
reactant: 027019
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

022862
stoichiometry: 1.0
species: 299166
type: SpeciesReference

027271
stoichiometry: 1.0
species: 299386
type: SpeciesReference

033218
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299230
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2/cyclin A2*/CDKN1B
type: Species

028747
stoichiometry: 1.0
species: 299843
type: SpeciesReference

029779
stoichiometry: 1.0
species: 299554
type: SpeciesReference

028891
stoichiometry: 1.0
species: 299843
type: SpeciesReference

301302
product: 034142
reactant: 034130
notes: PMID: 15014447
fast: false
reversible: false
type: Reaction

299583
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ECE1B
type: Species

299606
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ASK
type: Species

026175
stoichiometry: 1.0
species: 299671
type: SpeciesReference

033998
stoichiometry: 1.0
species: 299810
type: SpeciesReference

031441
stoichiometry: 1.0
species: 298923
type: SpeciesReference

029119
stoichiometry: 1.0
species: 299594
type: SpeciesReference

298868
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1
type: Species

299647
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RRM1
type: Species

299797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CHEK1
type: Species

021445
stoichiometry: 1.0
species: 299845
type: SpeciesReference

299058
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p15INK4b*
type: Species

300739
product: 029095
reactant: 029083
notes: Notes by CellDesigner PMID: 15510213 reaction: direct
fast: false
reversible: false
type: Reaction

028027
stoichiometry: 1.0
species: 299313
type: SpeciesReference

300266
modifier: 024950
product: 024938
reactant: 024926
reactant: 024914
notes: Phosphorylations on p53 prevent its binding to MDM2. PMID: 15140942 MDM2 phosphorylation by AKT favors the binding of MDM2 to p53 and its following degradation. PMID: 15574337
fast: false
reversible: false
type: Reaction

026659
stoichiometry: 1.0
species: 299840
type: SpeciesReference

029047
stoichiometry: 1.0
species: 299384
type: SpeciesReference

030411
stoichiometry: 1.0
species: 299585
type: SpeciesReference

033770
stoichiometry: 1.0
species: 299843
type: SpeciesReference

300987
product: 031141
reactant: 031129
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

301168
product: 032894
reactant: 032882
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

034347
stoichiometry: 1.0
species: 299825
type: SpeciesReference

030348
stoichiometry: 1.0
species: 298923
type: SpeciesReference

301129
product: 032510
reactant: 032498
fast: false
reversible: false
type: Reaction

033914
stoichiometry: 1.0
species: 299843
type: SpeciesReference

301079
product: 032030
reactant: 032018
notes: PMID: 16179649
fast: false
reversible: false
type: Reaction

300732
product: 029023
reactant: 029011
notes: Notes by CellDesigner PMID: 12438307 reaction: direct
fast: false
reversible: false
type: Reaction

030769
stoichiometry: 1.0
species: 298923
type: SpeciesReference

298863
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1
type: Species

028075
stoichiometry: 1.0
species: 299313
type: SpeciesReference

028783
stoichiometry: 1.0
species: 299583
type: SpeciesReference

299641
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ECE1C
type: Species

021181
stoichiometry: 1.0
species: 298985
type: SpeciesReference

300115
modifier: 023078
product: 023066
reactant: 023054
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false
type: Reaction

299600
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CYC
type: Species

031333
stoichiometry: 1.0
species: 299539
type: SpeciesReference

301233
product: 033494
reactant: 033482
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

023750
stoichiometry: 1.0
species: 299088
type: SpeciesReference

299589
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RPA2
type: Species

031405
stoichiometry: 1.0
species: 299462
type: SpeciesReference

299056
notes: The native protein is first correctly folded by HSP90 and CDC37 before being able to bind to the D-type cyclins. PMID: 10385618 PMID: 10498883 (NF = non folded)
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4
type: Species

034298
stoichiometry: 1.0
species: 299838
type: SpeciesReference

301166
product: 032870
reactant: 032858
notes: PMID: 11564866
fast: false
reversible: false
type: Reaction

021757
stoichiometry: 1.0
species: 299022
type: SpeciesReference

020749
stoichiometry: 1.0
species: 298956
type: SpeciesReference

025563
stoichiometry: 1.0
species: 298899
type: SpeciesReference

024194
stoichiometry: 1.0
species: 299233
type: SpeciesReference

022373
stoichiometry: 1.0
species: 299056
type: SpeciesReference

024878
stoichiometry: 1.0
species: 299797
type: SpeciesReference

033434
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299692
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FOXO1
type: Species

300734
product: 029047
reactant: 029035
notes: Notes by CellDesigner PMID: 12665581
fast: false
reversible: false
type: Reaction

300261
modifier: 024866
product: 024854
reactant: 024842
notes: PMID: 15829956 PMID: 15140942 Auto-phosphorylation catalysed by E2F1 PMID: 15024084 (ref REACTOME) PMID: 12556884 Autophosphorylation of ATM within dimeric ATM complexes
fast: false
reversible: false
type: Reaction

300887
product: 030235
reactant: 030223
notes: Notes by CellDesigner PMID: 15271987 reaction: direct
fast: false
reversible: false
type: Reaction

032462
stoichiometry: 1.0
species: 299674
type: SpeciesReference

031765
stoichiometry: 1.0
species: 299459
type: SpeciesReference

024146
stoichiometry: 1.0
species: 298958
type: SpeciesReference

029335
stoichiometry: 1.0
species: 299838
type: SpeciesReference

028363
stoichiometry: 1.0
species: 299313
type: SpeciesReference

032318
stoichiometry: 1.0
species: 299692
type: SpeciesReference

300221
product: 024350
reactant: 024338
reactant: 024326
fast: false
reversible: false
type: Reaction

020244
stoichiometry: 1.0
species: 298849
type: SpeciesReference

027931
stoichiometry: 1.0
species: 299313
type: SpeciesReference

300936
product: 030661
reactant: 030649
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

299917
product: 020653
product: 020641
product: 020629
reactant: 020617
fast: false
reversible: false
type: Reaction

299054
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4
type: Species

026719
stoichiometry: 1.0
species: 299496
type: SpeciesReference

299587
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RPL8
type: Species

300305
product: 025359
reactant: 025347
fast: false
reversible: false
type: Reaction

029995
stoichiometry: 1.0
species: 299596
type: SpeciesReference

033662
stoichiometry: 1.0
species: 299778
type: SpeciesReference

300482
product: 026863
reactant: 026851
notes: PMID: 15574337
fast: false
reversible: false
type: Reaction

033818
stoichiometry: 1.0
species: 298923
type: SpeciesReference

028963
stoichiometry: 1.0
species: 299843
type: SpeciesReference

300942
product: 030733
reactant: 030721
notes: Notes by CellDesigner PMID: 11564866 reaction: direct
fast: false
reversible: false
type: Reaction

029563
stoichiometry: 1.0
species: 299598
type: SpeciesReference

034142
stoichiometry: 1.0
species: 299527
type: SpeciesReference

019823
stoichiometry: 1.0
species: 298879
type: SpeciesReference

029623
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300623
product: 028087
reactant: 028075
notes: Notes by CellDesigner PMID: 12004135 reaction: direct
fast: false
reversible: false
type: Reaction

026211
stoichiometry: 1.0
species: 299840
type: SpeciesReference

031225
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299093
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK6/CDKN1B
type: Species

021553
stoichiometry: 1.0
species: 299042
type: SpeciesReference

300084
product: 022706
reactant: 022694
fast: false
reversible: false
type: Reaction

301309
product: 034190
reactant: 034178
notes: PMID: 16179649
fast: false
reversible: false
type: Reaction

028147
stoichiometry: 1.0
species: 299313
type: SpeciesReference

031549
stoichiometry: 1.0
species: 299656
type: SpeciesReference

024578
stoichiometry: 1.0
species: 299266
type: SpeciesReference

025611
stoichiometry: 1.0
species: 299794
type: SpeciesReference

299750
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TOPBP1
type: Species

022597
stoichiometry: 1.0
species: 299084
type: SpeciesReference

028579
stoichiometry: 1.0
species: 299843
type: SpeciesReference

030273
stoichiometry: 1.0
species: 298923
type: SpeciesReference

031957
stoichiometry: 1.0
species: 299681
type: SpeciesReference

300118
product: 023102
reactant: 023090
notes: PMID: 10373560 (from REACTOME) PMID: 11063929
fast: false
reversible: false
type: Reaction

299011
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: BAT8
type: Species

032246
stoichiometry: 1.0
species: 299665
type: SpeciesReference

030937
stoichiometry: 1.0
species: 298923
type: SpeciesReference

025995
stoichiometry: 1.0
species: 299840
type: SpeciesReference

028207
stoichiometry: 1.0
species: 299494
type: SpeciesReference

300159
product: 023582
reactant: 023570
notes: PMID: 11355576
fast: false
reversible: false
type: Reaction

300307
product: 025383
reactant: 025371
fast: false
reversible: false
type: Reaction

300331
product: 025671
reactant: 025659
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

300411
product: 026398
reactant: 026385
notes: PMID: 16144839
fast: false
reversible: false
type: Reaction

300198
modifier: 024062
product: 024050
reactant: 024038
notes: Phosphorylation of p27 at Thr-157 by AKT-1 induce its cytoplasmic localization. PMID: 12851486 Phosphorylation of p21 at Thr-145 by AKT-1 induce its cytoplasmic localization. PMID: 11231573
fast: false
reversible: false
type: Reaction

020629
stoichiometry: 1.0
species: 298912
type: SpeciesReference

021013
stoichiometry: 1.0
species: 298807
type: SpeciesReference

300839
product: 029899
reactant: 029887
notes: Notes by CellDesigner p14 ARF repressed by E2F3b PMID: 15177020 PMID: 15175242 reaction: direct
fast: false
reversible: false
type: Reaction

032582
stoichiometry: 1.0
species: 299527
type: SpeciesReference

034557
stoichiometry: 1.0
species: 299337
type: SpeciesReference

299091
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK6/cyclin D1*
type: Species

300625
product: 028111
reactant: 028099
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

020076
stoichiometry: 1.0
species: 298868
type: SpeciesReference

023054
stoichiometry: 1.0
species: 299175
type: SpeciesReference

022657
stoichiometry: 1.0
species: 299825
type: SpeciesReference

026827
stoichiometry: 1.0
species: 299840
type: SpeciesReference

301175
product: 032966
reactant: 032954
notes: PMID: 11564866
fast: false
reversible: false
type: Reaction

299864
product: 020028
product: 020016
product: 020004
reactant: 019992
notes: PMID: 15840440 PMID: 15133492
fast: false
reversible: false
type: Reaction

299051
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p16INK4a*
type: Species

299711
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SKP2
type: Species

033110
stoichiometry: 1.0
species: 299748
type: SpeciesReference

032186
stoichiometry: 1.0
species: 299661
type: SpeciesReference

020208
stoichiometry: 1.0
species: 298849
type: SpeciesReference

031093
stoichiometry: 1.0
species: 299612
type: SpeciesReference

300945
product: 030757
reactant: 030745
notes: Notes by CellDesigner PMID: 16158053 reaction: direct
fast: false
reversible: false
type: Reaction

029275
stoichiometry: 1.0
species: 299559
type: SpeciesReference

299013
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EED
type: Species

299539
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MRPL27
type: Species

027067
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300371
product: 026055
reactant: 026043
notes: PMID: 12389032
fast: false
reversible: false
type: Reaction

299650
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p68*
type: Species

025407
stoichiometry: 1.0
species: 299318
type: SpeciesReference

026935
stoichiometry: 1.0
species: 299466
type: SpeciesReference

300333
product: 025695
reactant: 025683
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

026875
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299486
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: GAB2
type: Species

300227
modifier: 024434
product: 024422
reactant: 024410
notes: CDK activity stimulated by its CAK-complex phosphorylation. PMID: 12459251 (ref REACTOME) PMID: 16782892
fast: false
reversible: false
type: Reaction

300729
product: 028999
reactant: 028987
notes: Notes by CellDesigner PMID: 11564866 reaction: direct
fast: false
reversible: false
type: Reaction

027979
stoichiometry: 1.0
species: 299313
type: SpeciesReference

027331
stoichiometry: 1.0
species: 299840
type: SpeciesReference

021637
stoichiometry: 1.0
species: 299031
type: SpeciesReference

299608
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RQCD1
type: Species

031693
stoichiometry: 1.0
species: 299596
type: SpeciesReference

021241
stoichiometry: 1.0
species: 298985
type: SpeciesReference

024350
stoichiometry: 1.0
species: 298992
type: SpeciesReference

033554
stoichiometry: 1.0
species: 299313
type: SpeciesReference

027631
stoichiometry: 1.0
species: 299570
type: SpeciesReference

026079
stoichiometry: 1.0
species: 299435
type: SpeciesReference

025347
stoichiometry: 1.0
species: 299311
type: SpeciesReference

032798
stoichiometry: 1.0
species: 299720
type: SpeciesReference

300088
modifier: 022766
product: 022754
reactant: 022742
notes: CDK activity stimulated by its CAK-complex phosphorylation. PMID: 12459251 PMID: 12814430 (ref REACTOME) PMID: 7799941
fast: false
reversible: false
type: Reaction

020496
stoichiometry: 1.0
species: 298946
type: SpeciesReference

032918
stoichiometry: 1.0
species: 299732
type: SpeciesReference

025959
stoichiometry: 1.0
species: 299512
type: SpeciesReference

025395
stoichiometry: 1.0
species: 299304
type: SpeciesReference

301001
product: 031285
reactant: 031273
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

031801
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299713
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SNRPE
type: Species

024422
stoichiometry: 1.0
species: 298962
type: SpeciesReference

026297
stoichiometry: 1.0
species: 299423
type: SpeciesReference

300300
modifier: 025311
product: 025299
reactant: 025287
notes: Phosphorylation at T145 is catalyzed by the protein serine/threonine kinase Akt PMID: 16775416 PMID: 15798220
fast: false
reversible: false
type: Reaction

299754
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TOP2A
type: Species

301172
product: 032942
reactant: 032930
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

300940
product: 030709
reactant: 030697
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

023162
stoichiometry: 1.0
species: 299166
type: SpeciesReference

022501
stoichiometry: 1.0
species: 299054
type: SpeciesReference

298901
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*/TopBP1
type: Species

300229
modifier: 024470
product: 024458
reactant: 024446
notes: CDK activity stimulated by its CAK-complex phosphorylation. PMID: 12459251 PMID: 12814430 (ref REACTOME) PMID: 16782892
fast: false
reversible: false
type: Reaction

023606
stoichiometry: 1.0
species: 299188
type: SpeciesReference

020893
stoichiometry: 1.0
species: 298953
type: SpeciesReference

299861
modifier: 019980
product: 019968
reactant: 019956
notes: Phosphorylation of E2F1 leads to the end of transcription stimulation. PMID: 15840440 Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation). PMID: 15133492 PMID: 9556498 PMID: 15123636 Phosphorylation of both DP-1 and E2F1 PMID: 16135794 Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation. PMID: 11980909 Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb. PMID: 16213134
fast: false
reversible: false
type: Reaction

030235
stoichiometry: 1.0
species: 299516
type: SpeciesReference

299689
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MYCN
type: Species

300880
product: 030163
reactant: 030151
notes: Notes by CellDesigner PMID: 15033491 reaction: direct
fast: false
reversible: false
type: Reaction

300629
product: 028135
reactant: 028123
notes: Notes by CellDesigner PMID: 10998368
fast: false
reversible: false
type: Reaction

298980
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*/SWI/SNF/_br_HDAC1/SUV39H1/HP1gamma*
type: Species

300335
product: 025719
reactant: 025707
notes: PMID: 12149244
fast: false
reversible: false
type: Reaction

300415
product: 026424
reactant: 026411
notes: PMID: 15304485
fast: false
reversible: false
type: Reaction

300086
product: 022730
reactant: 022718
notes: PMID: 10373560 PMID: 10395539 (from REACTOME) PMID: 11063929
fast: false
reversible: false
type: Reaction

028819
stoichiometry: 1.0
species: 299843
type: SpeciesReference

026322
stoichiometry: 1.0
species: 299505
type: SpeciesReference

301003
product: 031309
reactant: 031297
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

299715
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SIVA
type: Species

300302
product: 025335
reactant: 025323
notes: Relocalization of p21 from the nucleus to the cytosol PMID: 16775416 (from REACTOME) PMID: 9632134
fast: false
reversible: false
type: Reaction

028423
stoichiometry: 1.0
species: 299647
type: SpeciesReference

033266
stoichiometry: 1.0
species: 299840
type: SpeciesReference

301307
product: 034166
reactant: 034154
notes: PMID: 16512785
fast: false
reversible: false
type: Reaction

030985
stoichiometry: 1.0
species: 298923
type: SpeciesReference

031585
stoichiometry: 1.0
species: 298923
type: SpeciesReference

029911
stoichiometry: 1.0
species: 299838
type: SpeciesReference

028195
stoichiometry: 1.0
species: 299313
type: SpeciesReference

032294
stoichiometry: 1.0
species: 299667
type: SpeciesReference

301170
product: 032918
reactant: 032906
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

026139
stoichiometry: 1.0
species: 299840
type: SpeciesReference

030553
stoichiometry: 1.0
species: 298923
type: SpeciesReference

023282
stoichiometry: 1.0
species: 299180
type: SpeciesReference

025287
stoichiometry: 1.0
species: 299825
type: SpeciesReference

029167
stoichiometry: 1.0
species: 299838
type: SpeciesReference

020388
stoichiometry: 1.0
species: 298872
type: SpeciesReference

021975
stoichiometry: 1.0
species: 299051
type: SpeciesReference

023018
stoichiometry: 1.0
species: 299173
type: SpeciesReference

299757
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: UHRF1
type: Species

031285
stoichiometry: 1.0
species: 299545
type: SpeciesReference

299534
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MTHFD1
type: Species

300779
product: 029443
reactant: 029431
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

031009
stoichiometry: 1.0
species: 298923
type: SpeciesReference

031501
stoichiometry: 1.0
species: 299384
type: SpeciesReference

025659
stoichiometry: 1.0
species: 299840
type: SpeciesReference

298827
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: DP1*
type: Species

300376
product: 026079
reactant: 026067
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

033638
stoichiometry: 1.0
species: 299778
type: SpeciesReference

300153
modifier: 023522
product: 023510
reactant: 023498
notes: PMID: 16123593
fast: false
reversible: false
type: Reaction

029803
stoichiometry: 1.0
species: 299462
type: SpeciesReference

028927
stoichiometry: 1.0
species: 299683
type: SpeciesReference

024530
stoichiometry: 1.0
species: 299221
type: SpeciesReference

028531
stoichiometry: 1.0
species: 299843
type: SpeciesReference

300553
product: 027439
reactant: 027427
fast: false
reversible: false
type: Reaction

025095
stoichiometry: 1.0
species: 299300
type: SpeciesReference

298903
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p130*
type: Species

299018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP1*/EPC1/EZH2/EED
type: Species

300489
product: 026935
reactant: 026923
notes: PMID: 14684737
fast: false
reversible: false
type: Reaction

299164
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2
type: Species

299951
product: 021121
reactant: 021109
reactant: 021097
notes: PMID: 11533237 PMID: 11484059 PMID: 15126619 PMID: 11420729 PMID: 15838516
fast: false
reversible: false
type: Reaction

022439
stoichiometry: 1.0
species: 299110
type: SpeciesReference

024242
stoichiometry: 1.0
species: 299228
type: SpeciesReference

301281
product: 033926
reactant: 033914
notes: PMID: 16580749
fast: false
reversible: false
type: Reaction

300418
product: 026450
reactant: 026437
notes: PMID: 15313206
fast: false
reversible: false
type: Reaction

299838
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F3_alone
type: Species

030127
stoichiometry: 1.0
species: 298923
type: SpeciesReference

021529
stoichiometry: 1.0
species: 298827
type: SpeciesReference

023246
stoichiometry: 1.0
species: 299164
type: SpeciesReference

299330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p53*/MDM2
type: Species

299483
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MYC
type: Species

026551
stoichiometry: 1.0
species: 299470
type: SpeciesReference

021133
stoichiometry: 1.0
species: 298976
type: SpeciesReference

034070
stoichiometry: 1.0
species: 299814
type: SpeciesReference

298985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*/SWI/SNF/HDAC1
type: Species

029095
stoichiometry: 1.0
species: 299378
type: SpeciesReference

299759
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: UBB
type: Species

299954
product: 021157
reactant: 021145
reactant: 021133
notes: The recruitment of SUV39H1 allows that of HP1 PMID: 11484059 PMID: 15126619 PMID: 11420729 PMID: 15838516
fast: false
reversible: false
type: Reaction

298946
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F4/DP2*
type: Species

300378
product: 026103
reactant: 026091
notes: PMID: 15510213
fast: false
reversible: false
type: Reaction

300151
modifier: 023486
product: 023474
reactant: 023462
notes: PMID: 15840442
fast: false
reversible: false
type: Reaction

299126
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin B1*
type: Species

030450
stoichiometry: 1.0
species: 298923
type: SpeciesReference

032714
stoichiometry: 1.0
species: 298923
type: SpeciesReference

033746
stoichiometry: 1.0
species: 299840
type: SpeciesReference

031657
stoichiometry: 1.0
species: 298923
type: SpeciesReference

023714
stoichiometry: 1.0
species: 299219
type: SpeciesReference

033158
stoichiometry: 1.0
species: 299750
type: SpeciesReference

030877
stoichiometry: 1.0
species: 299455
type: SpeciesReference

022477
stoichiometry: 1.0
species: 299117
type: SpeciesReference

299166
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC2/cyclin B1*
type: Species

034310
stoichiometry: 1.0
species: 299667
type: SpeciesReference

033890
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300776
product: 029419
reactant: 029407
notes: Notes by CellDesigner PMID: 10733529 PMID: 10766737 reaction: direct
fast: false
reversible: false
type: Reaction

301007
product: 031333
reactant: 031321
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

299332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDKN3
type: Species

298906
notes: Shuttling of p130 between the nucleus and cytoplasm PMID: 11756542
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p130*
type: Species

300550
product: 027415
reactant: 027403
notes: PMID: 16181749
fast: false
reversible: false
type: Reaction

300459
product: 026791
reactant: 026779
notes: PMID: 12944911
fast: false
reversible: false
type: Reaction

027823
stoichiometry: 1.0
species: 299516
type: SpeciesReference

299444
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: AXIN2
type: Species

298983
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SUV39H1/_br_HP1gamma*
type: Species

299270
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2/CDKN1A
type: Species

299531
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: NEK2
type: Species

301286
product: 033974
reactant: 033962
notes: PMID: 12368233
fast: false
reversible: false
type: Reaction

299128
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: WEE1
type: Species

032750
stoichiometry: 1.0
species: 299715
type: SpeciesReference

025911
stoichiometry: 1.0
species: 299439
type: SpeciesReference

023822
stoichiometry: 1.0
species: 299226
type: SpeciesReference

299097
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4
type: Species

020665
stoichiometry: 1.0
species: 298923
type: SpeciesReference

030163
stoichiometry: 1.0
species: 299518
type: SpeciesReference

299956
modifier: 021193
product: 021181
reactant: 021169
notes: Induce the G0 to G1 transition: phosphorylated pocket proteins stop repressing ribosomal RNA and tRNA gene expression. PMID: 15838516
fast: false
reversible: false
type: Reaction

031849
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299228
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: APC/FZR1
type: Species

021661
stoichiometry: 1.0
species: 299845
type: SpeciesReference

028255
stoichiometry: 1.0
species: 299394
type: SpeciesReference

026515
stoichiometry: 1.0
species: 299840
type: SpeciesReference

027679
stoichiometry: 1.0
species: 299587
type: SpeciesReference

300309
product: 025407
reactant: 025395
notes: Phosphorylated CDC25 interacts with the 14-3-3 proteins which keep CDC25 outside of the nucleus. PMID: 12814430 PMID: 11313932 PMID: 11897663
fast: false
reversible: false
type: Reaction

299867
product: 020064
reactant: 020052
reactant: 020040
fast: false
reversible: false
type: Reaction

300156
product: 023558
product: 023546
reactant: 023534
fast: false
reversible: false
type: Reaction

301009
product: 031357
reactant: 031345
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

022387
stoichiometry: 1.0
species: 299082
type: SpeciesReference

030079
stoichiometry: 1.0
species: 299838
type: SpeciesReference

029671
stoichiometry: 1.0
species: 299838
type: SpeciesReference

021829
stoichiometry: 1.0
species: 299063
type: SpeciesReference

029227
stoichiometry: 1.0
species: 299367
type: SpeciesReference

298822
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CREBBP
type: Species

299537
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MSH2
type: Species

023354
stoichiometry: 1.0
species: 299173
type: SpeciesReference

299168
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2
type: Species

298989
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SWI/SNF/HDAC1/SUV39H1/_br_pRB*/E2F1/DP1*
type: Species

034359
stoichiometry: 1.0
species: 299823
type: SpeciesReference

300485
product: 026887
reactant: 026875
notes: PMID: 14990995
fast: false
reversible: false
type: Reaction

027379
stoichiometry: 1.0
species: 299840
type: SpeciesReference

024398
stoichiometry: 1.0
species: 299255
type: SpeciesReference

032018
stoichiometry: 1.0
species: 299311
type: SpeciesReference

031045
stoichiometry: 1.0
species: 299619
type: SpeciesReference

298908
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SUV39H1
type: Species

300620
product: 028063
reactant: 028051
notes: PMID: 15574595
fast: false
reversible: false
type: Reaction

030829
stoichiometry: 1.0
species: 299346
type: SpeciesReference

020340
stoichiometry: 1.0
species: 298879
type: SpeciesReference

299335
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CHEK2
type: Species

025058
stoichiometry: 1.0
species: 299293
type: SpeciesReference

022321
stoichiometry: 1.0
species: 299101
type: SpeciesReference

032822
stoichiometry: 1.0
species: 299728
type: SpeciesReference

023426
stoichiometry: 1.0
species: 299162
type: SpeciesReference

025887
stoichiometry: 1.0
species: 299574
type: SpeciesReference

033854
stoichiometry: 1.0
species: 299786
type: SpeciesReference

019872
stoichiometry: 1.0
species: 298835
type: SpeciesReference

299441
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BBC3
type: Species

299095
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4/CDKN1B
type: Species

299219
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p27Kip1*
type: Species

026476
stoichiometry: 1.0
species: 299600
type: SpeciesReference

301179
product: 032990
reactant: 032978
notes: PMID: 12446714
fast: false
reversible: false
type: Reaction

029491
stoichiometry: 1.0
species: 299425
type: SpeciesReference

027787
stoichiometry: 1.0
species: 299663
type: SpeciesReference

029959
stoichiometry: 1.0
species: 299838
type: SpeciesReference

299016
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP1*/EPC1
type: Species

299869
modifier: 020100
product: 020088
reactant: 020076
notes: E2F1 deacetylated by pRB/HDAC PMID: 15126619 Deacetylation by HDAC1 PMID: 10753885
fast: false
reversible: false
type: Reaction

027223
stoichiometry: 1.0
species: 299483
type: SpeciesReference

021409
stoichiometry: 1.0
species: 299040
type: SpeciesReference

299380
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p14ARF*
type: Species

022232
stoichiometry: 1.0
species: 299104
type: SpeciesReference

022549
stoichiometry: 1.0
species: 299054
type: SpeciesReference

034034
stoichiometry: 1.0
species: 299309
type: SpeciesReference

298949
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p107*/E2F4/DP2*
type: Species

301283
product: 033950
reactant: 033938
notes: PMID: 16741925
fast: false
reversible: false
type: Reaction

300660
product: 028375
reactant: 028363
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

298824
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: DP1*
type: Species

028855
stoichiometry: 1.0
species: 299412
type: SpeciesReference

024602
stoichiometry: 1.0
species: 299825
type: SpeciesReference

300487
product: 026911
reactant: 026899
notes: PMID: 15985428
fast: false
reversible: false
type: Reaction

298987
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*/SWI/SNF
type: Species

022946
stoichiometry: 1.0
species: 299175
type: SpeciesReference

032438
stoichiometry: 1.0
species: 299810
type: SpeciesReference

299481
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: p180*
type: Species

029887
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300772
product: 029395
reactant: 029383
notes: Notes by CellDesigner PMID: 10733529 PMID: 15510213 reaction: direct
fast: false
reversible: false
type: Reaction

021061
stoichiometry: 1.0
species: 298813
type: SpeciesReference

027151
stoichiometry: 1.0
species: 299554
type: SpeciesReference

033026
stoichiometry: 1.0
species: 299840
type: SpeciesReference

028663
stoichiometry: 1.0
species: 299423
type: SpeciesReference

020172
stoichiometry: 1.0
species: 298854
type: SpeciesReference

300723
product: 028927
reactant: 028915
notes: Notes by CellDesigner PMID: 14990995 reaction: indirect intermediate: MYC
fast: false
reversible: false
type: Reaction

301138
product: 032606
reactant: 032594
notes: PMID: 15713665
fast: false
reversible: false
type: Reaction

021325
stoichiometry: 1.0
species: 298987
type: SpeciesReference

022670
stoichiometry: 1.0
species: 299097
type: SpeciesReference

020232
stoichiometry: 1.0
species: 298863
type: SpeciesReference

029239
stoichiometry: 1.0
species: 299838
type: SpeciesReference

298810
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*
type: Species

299525
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PRKDC
type: Species

300909
product: 030463
reactant: 030450
notes: Notes by CellDesigner PMID: 10766737 reaction: direct
fast: false
reversible: false
type: Reaction

300656
product: 028327
reactant: 028315
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

300763
product: 029299
reactant: 029287
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

299375
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PMAIP1
type: Species

026683
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299576
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F5 cofactors
type: Species

028399
stoichiometry: 1.0
species: 299369
type: SpeciesReference

299801
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p57KIP2*
type: Species

300258
modifier: 024830
modifier: 024818
product: 024806
reactant: 024794
notes: PMID: 15024084 PMID: 15140942
fast: false
reversible: false
type: Reaction

298892
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*/PCAF
type: Species

034594
stoichiometry: 1.0
species: 299843
type: SpeciesReference

300195
modifier: 024026
modifier: 024014
product: 024002
reactant: 023990
notes: PMID: 10548110 (ref REACTOME) PMID: 11598127 (CycB phosphorylates CDH1)
fast: false
reversible: false
type: Reaction

031777
stoichiometry: 1.0
species: 298923
type: SpeciesReference

024842
stoichiometry: 1.0
species: 299275
type: SpeciesReference

032498
stoichiometry: 1.0
species: 299840
type: SpeciesReference

020713
stoichiometry: 1.0
species: 298807
type: SpeciesReference

300104
modifier: 022970
product: 022958
reactant: 022946
notes: Phosphorylation only when CDC2 is bound to the cyclin D. PMID: 10373560 PMID: 9001210 PMID: 12814430
fast: false
reversible: false
type: Reaction

021745
stoichiometry: 1.0
species: 298931
type: SpeciesReference

033194
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300145
modifier: 023414
product: 023402
reactant: 023390
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false
type: Reaction

301311
product: 034214
reactant: 034202
fast: false
reversible: false
type: Reaction

032630
stoichiometry: 1.0
species: 299681
type: SpeciesReference

299401
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: LGALS1
type: Species

299639
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ACR
type: Species

020436
stoichiometry: 1.0
species: 298939
type: SpeciesReference

022742
stoichiometry: 1.0
species: 299166
type: SpeciesReference

031321
stoichiometry: 1.0
species: 298923
type: SpeciesReference

026575
stoichiometry: 1.0
species: 299499
type: SpeciesReference

026031
stoichiometry: 1.0
species: 299561
type: SpeciesReference

299523
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PSMA4
type: Species

300907
product: 030437
reactant: 030424
notes: Notes by CellDesigner PMID: 15510213 PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

300658
product: 028351
reactant: 028339
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

028087
stoichiometry: 1.0
species: 299507
type: SpeciesReference

300255
reversible: false
modifier: 024758
reactant: 024734
product: 024746
notes: PMID: 15024084 ATM phosphorylates p53 in case of DNA double-strand breaks. ATR phosphorylates p53 in case of other types of DNA damages. PMID: 15140942 E2F1 stimulates ATM to phosphorylate p53 (and Chk2) PMID: 15140942 (ref REACTOME) PMID: 9843217 PMID: 9733515 PMID: 9733514
modifier: 024770
type: Reaction
fast: false
modifier: 024782

298851
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a22_degraded
type: Species

030697
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299578
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F7 cofactors
type: Species

299373
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PNRC2
type: Species

300761
product: 029275
reactant: 029263
notes: PMID: 15510213
fast: false
reversible: false
type: Reaction

030733
stoichiometry: 1.0
species: 299598
type: SpeciesReference

300048
product: 022360
reactant: 022347
fast: false
reversible: false
type: Reaction

300102
product: 022934
reactant: 022922
reactant: 022910
notes: Cytoplasmic binding PMID: 9001210 (ref REACTOME) PMID: 1717476
fast: false
reversible: false
type: Reaction

299976
product: 021445
reactant: 021433
notes: PMID: 15536069
fast: false
reversible: false
type: Reaction

033902
stoichiometry: 1.0
species: 299786
type: SpeciesReference

299637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BARD1
type: Species

298813
notes: Inhibition of E2F binding by phosphorylation at several of the 7 C-terminal sites or at one of the two serines 807 and 811. PMID : 9315635
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*
type: Species

300143
modifier: 023378
product: 023366
reactant: 023354
notes: Phosphorylation only when CDC2 is bound to the cyclin D. PMID: 10373560 PMID: 9001210 PMID: 12814430
fast: false
reversible: false
type: Reaction

025046
stoichiometry: 1.0
species: 299280
type: SpeciesReference

299268
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2/CDKN1A
type: Species

300999
product: 031261
reactant: 031249
notes: Notes by CellDesigner PMID: 15195143 reaction: direct
fast: false
reversible: false
type: Reaction

026647
stoichiometry: 1.0
species: 299343
type: SpeciesReference

300727
product: 028975
reactant: 028963
notes: Notes by CellDesigner PMID: 10766737 reaction: direct
fast: false
reversible: false
type: Reaction

023894
stoichiometry: 1.0
species: 299193
type: SpeciesReference

029743
stoichiometry: 1.0
species: 299838
type: SpeciesReference

021433
stoichiometry: 1.0
species: 299042
type: SpeciesReference

031477
stoichiometry: 1.0
species: 299531
type: SpeciesReference

300140
modifier: 023342
product: 023330
reactant: 023318
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430 (ref REACTOME) PMID: 10827953 PMID: 8440392 PMID: 15456846 PMID: 12524548 PMID: 8119945 PMID: 8428594 PMID: 15107615 PMID: 12411508
fast: false
reversible: false
type: Reaction

033986
stoichiometry: 1.0
species: 299838
type: SpeciesReference

298897
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298791
name: p14ARF*/DP1*
type: Species

023474
stoichiometry: 1.0
species: 299142
type: SpeciesReference

028735
stoichiometry: 1.0
species: 299598
type: SpeciesReference

024050
stoichiometry: 1.0
species: 299221
type: SpeciesReference

299339
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F1
type: Species

028327
stoichiometry: 1.0
species: 299378
type: SpeciesReference

031177
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300042
modifier: 022308
product: 022295
reactant: 022282
notes: PMID: 12459251 PMID: 10385618 (ref REACTOME) PMID: 16732330
fast: false
reversible: false
type: Reaction

024326
stoichiometry: 1.0
species: 299243
type: SpeciesReference

301288
product: 033998
reactant: 033986
notes: PMID: 12368233
fast: false
reversible: false
type: Reaction

032342
stoichiometry: 1.0
species: 299701
type: SpeciesReference

298857
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: PCAF
type: Species

299371
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RBBP4
type: Species

020869
stoichiometry: 1.0
species: 298937
type: SpeciesReference

300651
product: 028279
reactant: 028267
notes: Notes by CellDesigner PMID: 12004135 reaction: direct
fast: false
reversible: false
type: Reaction

299572
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PFKFB*
type: Species

298956
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*/SWI/SNF/HDAC1
type: Species

300767
product: 029347
reactant: 029335
notes: PMID: 8618861 PMID: 10733529
fast: false
reversible: false
type: Reaction

034507
stoichiometry: 1.0
species: 298960
type: SpeciesReference

025743
stoichiometry: 1.0
species: 299606
type: SpeciesReference

031729
stoichiometry: 1.0
species: 298923
type: SpeciesReference

029455
stoichiometry: 1.0
species: 299838
type: SpeciesReference

025503
stoichiometry: 1.0
species: 298857
type: SpeciesReference

024662
stoichiometry: 1.0
species: 299168
type: SpeciesReference

300725
product: 028951
reactant: 028939
notes: Notes by CellDesigner PMID: 16144839
fast: false
reversible: false
type: Reaction

032030
stoichiometry: 1.0
species: 299559
type: SpeciesReference

027499
stoichiometry: 1.0
species: 299840
type: SpeciesReference

032930
stoichiometry: 1.0
species: 299840
type: SpeciesReference

298854
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: TOPBP1
type: Species

300192
modifier: 023978
modifier: 023966
product: 023954
reactant: 023942
notes: Degradation during G1 by APC/C(FZR1) PMID: 15840442 PMID: 15577895 Degradation during M by APC/C(CDC20) PMID: 15577895
fast: false
reversible: false
type: Reaction

020124
stoichiometry: 1.0
species: 298863
type: SpeciesReference

023318
stoichiometry: 1.0
species: 299180
type: SpeciesReference

300654
product: 028303
reactant: 028291
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

020797
stoichiometry: 1.0
species: 298921
type: SpeciesReference

299979
product: 021481
reactant: 021469
reactant: 021457
notes: PMID: 15536069
fast: false
reversible: false
type: Reaction

301208
product: 033254
reactant: 033242
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

026971
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299337
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F cofactors
type: Species

033086
stoichiometry: 1.0
species: 299748
type: SpeciesReference

030187
stoichiometry: 1.0
species: 299637
type: SpeciesReference

299108
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin D1*/CDK4
type: Species

300044
product: 022334
reactant: 022321
notes: PMID: 12459251 PMID: 10385618 T286 phosphorylation promote association of cyclin D1 with its nuclear exporter CRM1, leading to cytoplasmic translocation of cylcin D1 PMID: 12851486
fast: false
reversible: false
type: Reaction

029515
stoichiometry: 1.0
species: 299505
type: SpeciesReference

299948
modifier: 021085
product: 021073
reactant: 021061
notes: PMID: 8380224 PMID: 9315635 PMID: 10773440
fast: false
reversible: false
type: Reaction

299520
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RAD54L
type: Species

023630
stoichiometry: 1.0
species: 299224
type: SpeciesReference

024734
stoichiometry: 1.0
species: 299282
type: SpeciesReference

030091
stoichiometry: 1.0
species: 299681
type: SpeciesReference

025443
stoichiometry: 1.0
species: 299128
type: SpeciesReference

020809
stoichiometry: 1.0
species: 298942
type: SpeciesReference

300765
product: 029323
reactant: 029311
notes: Notes by CellDesigner CCND3 induced by E2F3a PMID: 12611887
fast: false
reversible: false
type: Reaction

299403
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: JMY
type: Species

031885
stoichiometry: 1.0
species: 299610
type: SpeciesReference

298817
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EP300
type: Species

030625
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300878
product: 030139
reactant: 030127
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

028291
stoichiometry: 1.0
species: 299313
type: SpeciesReference

301313
product: 034238
reactant: 034226
fast: false
reversible: false
type: Reaction

299574
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BCL2
type: Species

298894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/p14ARF*
type: Species

298958
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2
type: Species

023114
stoichiometry: 1.0
species: 299157
type: SpeciesReference

024134
stoichiometry: 1.0
species: 298958
type: SpeciesReference

301043
product: 031693
reactant: 031681
notes: Notes by CellDesigner PMID: 15711575 PMID: 12110166 reaction: direct
fast: false
reversible: false
type: Reaction

029347
stoichiometry: 1.0
species: 299671
type: SpeciesReference

028351
stoichiometry: 1.0
species: 299459
type: SpeciesReference

301244
product: 033614
reactant: 033602
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

032450
stoichiometry: 1.0
species: 299840
type: SpeciesReference

033446
stoichiometry: 1.0
species: 299770
type: SpeciesReference

025551
stoichiometry: 1.0
species: 298881
type: SpeciesReference

300992
product: 031189
reactant: 031177
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

300543
product: 027343
reactant: 027331
notes: PMID: 15510213
fast: false
reversible: false
type: Reaction

299630
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CSTF1
type: Species

029407
stoichiometry: 1.0
species: 299838
type: SpeciesReference

032678
stoichiometry: 1.0
species: 299701
type: SpeciesReference

026863
stoichiometry: 1.0
species: 299486
type: SpeciesReference

027727
stoichiometry: 1.0
species: 299645
type: SpeciesReference

026707
stoichiometry: 1.0
species: 299840
type: SpeciesReference

023582
stoichiometry: 1.0
species: 299155
type: SpeciesReference

027415
stoichiometry: 1.0
species: 299373
type: SpeciesReference

299905
product: 020521
reactant: 020509
reactant: 020496
notes: PMID: 15231644
fast: false
reversible: false
type: Reaction

022400
stoichiometry: 1.0
species: 299113
type: SpeciesReference

027199
stoichiometry: 1.0
species: 299462
type: SpeciesReference

300900
product: 030360
reactant: 030348
notes: PMID: 15510213 PMID: 10766737
fast: false
reversible: false
type: Reaction

301066
product: 031909
reactant: 031897
notes: PMID: 16135806
fast: false
reversible: false
type: Reaction

299681
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RRM2
type: Species

301131
product: 032534
reactant: 032522
notes: PMID: 17178835
fast: false
reversible: false
type: Reaction

299448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: APAF1
type: Species

021925
stoichiometry: 1.0
species: 299044
type: SpeciesReference

300952
product: 030805
reactant: 030793
notes: Notes by CellDesigner PMID: 10766737 PMID: 14576826 reaction: direct
fast: false
reversible: false
type: Reaction

030019
stoichiometry: 1.0
species: 299594
type: SpeciesReference

298899
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*
type: Species

030424
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299794
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: MDM2
type: Species

033386
stoichiometry: 1.0
species: 299838
type: SpeciesReference

299406
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ISYNA1
type: Species

300990
product: 031165
reactant: 031153
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

299261
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: PCNA
type: Species

300873
product: 030115
reactant: 030103
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

029707
stoichiometry: 1.0
species: 299362
type: SpeciesReference

026103
stoichiometry: 1.0
species: 299432
type: SpeciesReference

022452
stoichiometry: 1.0
species: 299054
type: SpeciesReference

021962
stoichiometry: 1.0
species: 299054
type: SpeciesReference

034286
stoichiometry: 1.0
species: 299667
type: SpeciesReference

031249
stoichiometry: 1.0
species: 298923
type: SpeciesReference

301068
product: 031933
reactant: 031921
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

299570
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RBM25
type: Species

031369
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299683
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM7
type: Species

299903
product: 020484
reactant: 020472
reactant: 020460
notes: PMID: 10964686
fast: false
reversible: false
type: Reaction

023786
stoichiometry: 1.0
species: 299088
type: SpeciesReference

020917
stoichiometry: 1.0
species: 298951
type: SpeciesReference

299446
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ATP5J
type: Species

301133
product: 032558
reactant: 032546
fast: false
reversible: false
type: Reaction

020821
stoichiometry: 1.0
species: 298942
type: SpeciesReference

299529
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PLK1
type: Species

032522
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MDM2
type: Species

300996
product: 031237
reactant: 031225
notes: Notes by CellDesigner PMID: 14990995 reaction: indirect intermediate: MYC
fast: false
reversible: false
type: Reaction

299973
product: 021421
reactant: 021409
fast: false
reversible: false
type: Reaction

024098
stoichiometry: 1.0
species: 299224
type: SpeciesReference

300905
product: 030411
reactant: 030398
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

299634
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BTRC
type: Species

021853
stoichiometry: 1.0
species: 299044
type: SpeciesReference

301061
product: 031861
reactant: 031849
notes: PMID: 10766737 PMID: 16135806
fast: false
reversible: false
type: Reaction

300214
product: 024278
reactant: 024266
reactant: 024254
fast: false
reversible: false
type: Reaction

300871
product: 030091
reactant: 030079
notes: Notes by CellDesigner PMID: 10733529 PMID: 15014447 reaction: direct
fast: false
reversible: false
type: Reaction

300148
modifier: 023450
product: 023438
reactant: 023426
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false
type: Reaction

025839
stoichiometry: 1.0
species: 299444
type: SpeciesReference

300546
product: 027367
reactant: 027355
notes: PMID: 12139485
fast: false
reversible: false
type: Reaction

299685
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CCNE1
type: Species

301040
product: 031669
reactant: 031657
notes: Notes by CellDesigner PMID: 16135806 reaction: directPMID: 15574595
fast: false
reversible: false
type: Reaction

029035
stoichiometry: 1.0
species: 299843
type: SpeciesReference

301135
product: 032582
reactant: 032570
notes: PMID: 12748276 PMID: 15574595
fast: false
reversible: false
type: Reaction

026187
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299266
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: PCNA/CDKN1A
type: Species

299040
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F6/DP2*
type: Species

022898
stoichiometry: 1.0
species: 299177
type: SpeciesReference

300609
product: 027967
reactant: 027955
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

299378
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PCNA
type: Species

023678
stoichiometry: 1.0
species: 299195
type: SpeciesReference

034421
stoichiometry: 1.0
species: 298906
type: SpeciesReference

021373
stoichiometry: 1.0
species: 298994
type: SpeciesReference

299790
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MDM2
type: Species

301242
product: 033590
reactant: 033578
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

027139
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299900
product: 020448
reactant: 020436
notes: E2F4 does not possess the NLS (nuclear localisation signal). Translocation in the nucleus only when bound to DP2 and/or p130/p107. Located in the nucleus only during G0 and G1. PMID: 9372959 PMID: 11959842
fast: false
reversible: false
type: Reaction

027391
stoichiometry: 1.0
species: 299375
type: SpeciesReference

301063
product: 031885
reactant: 031873
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

299632
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CHEK1
type: Species

022109
stoichiometry: 1.0
species: 299091
type: SpeciesReference

299527
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: POLA
type: Species

029395
stoichiometry: 1.0
species: 299427
type: SpeciesReference

299971
product: 021397
reactant: 021385
reactant: 021373
fast: false
reversible: false
type: Reaction

033494
stoichiometry: 1.0
species: 299772
type: SpeciesReference

028627
stoichiometry: 1.0
species: 299843
type: SpeciesReference

300994
product: 031213
reactant: 031201
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

033590
stoichiometry: 1.0
species: 299778
type: SpeciesReference

300548
product: 027391
reactant: 027379
notes: PMID: 14684737
fast: false
reversible: false
type: Reaction

025155
stoichiometry: 1.0
species: 299300
type: SpeciesReference

300252
modifier: 024722
product: 024710
reactant: 024698
notes: Phosphorylation initiated by E2F1. PMID: 15024084 E2F1 stimulates ATM to phosphorylate p53 (and Chk2) PMID: 15140942 (ref REACTOME) PMID: 12773400 PMID: 10973490
fast: false
reversible: false
type: Reaction

027451
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300902
product: 030385
reactant: 030373
notes: PMID: 15510213
fast: false
reversible: false
type: Reaction

027523
stoichiometry: 1.0
species: 299840
type: SpeciesReference

022011
stoichiometry: 1.0
species: 299044
type: SpeciesReference

032978
stoichiometry: 1.0
species: 299840
type: SpeciesReference

019799
stoichiometry: 1.0
species: 298835
type: SpeciesReference

034658
stoichiometry: 1.0
species: 299576
type: SpeciesReference

023918
stoichiometry: 1.0
species: 299207
type: SpeciesReference

300954
product: 030829
reactant: 030817
notes: Notes by CellDesigner PMID: 14633988 reaction: direct
fast: false
reversible: false
type: Reaction

300211
product: 024242
reactant: 024230
reactant: 024218
fast: false
reversible: false
type: Reaction

030398
stoichiometry: 1.0
species: 298923
type: SpeciesReference

024806
stoichiometry: 1.0
species: 299287
type: SpeciesReference

026755
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299687
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: H19
type: Species

032078
stoichiometry: 1.0
species: 299556
type: SpeciesReference

034396
stoichiometry: 1.0
species: 298958
type: SpeciesReference

300607
product: 027943
reactant: 027931
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

299044
notes: Like CDK4, CDK6 has first to be folded by HSP90 and CDC37 before being able to bind D-type cyclins. PMID: 10385618 PMID: 10498883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6
type: Species

300008
product: 021877
reactant: 021865
reactant: 021853
notes: sequestration of CDK6 to prevent its association with Cyclins D and RB phosphorylation PMID: 11960696 (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false
type: Reaction

025671
stoichiometry: 1.0
species: 299453
type: SpeciesReference

029899
stoichiometry: 1.0
species: 299380
type: SpeciesReference

299300
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p14ARF*/MDM2
type: Species

299005
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F8
type: Species

020328
stoichiometry: 1.0
species: 298877
type: SpeciesReference

026463
stoichiometry: 1.0
species: 299840
type: SpeciesReference

022958
stoichiometry: 1.0
species: 299177
type: SpeciesReference

300696
product: 028687
reactant: 028675
notes: Notes by CellDesigner PMID: 14990995 reaction: direct
fast: false
reversible: false
type: Reaction

299110
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC37/HSP90/CDK4
type: Species

300097
modifier: 022874
product: 022862
reactant: 022850
notes: dephosphorylation of CDC2 induce its activation PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false
type: Reaction

027235
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299082
notes: Targets HSP90 to CDK4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC37
type: Species

028771
stoichiometry: 1.0
species: 299843
type: SpeciesReference

023150
stoichiometry: 1.0
species: 299166
type: SpeciesReference

028507
stoichiometry: 1.0
species: 299843
type: SpeciesReference

025227
stoichiometry: 1.0
species: 299322
type: SpeciesReference

299676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: uPA
type: Species

029179
stoichiometry: 1.0
species: 299658
type: SpeciesReference

023294
stoichiometry: 1.0
species: 299177
type: SpeciesReference

025299
stoichiometry: 1.0
species: 299818
type: SpeciesReference

300618
product: 028039
reactant: 028027
notes: Notes by CellDesigner PMID: 12771133 reaction: direct
fast: false
reversible: false
type: Reaction

030541
stoichiometry: 1.0
species: 299423
type: SpeciesReference

028183
stoichiometry: 1.0
species: 299339
type: SpeciesReference

032282
stoichiometry: 1.0
species: 299840
type: SpeciesReference

029923
stoichiometry: 1.0
species: 299378
type: SpeciesReference

033866
stoichiometry: 1.0
species: 299838
type: SpeciesReference

032858
stoichiometry: 1.0
species: 299840
type: SpeciesReference

034470
stoichiometry: 1.0
species: 298910
type: SpeciesReference

300218
modifier: 024314
product: 024302
reactant: 024290
notes: PMID: 15840442 PMID: 11598127
fast: false
reversible: false
type: Reaction

033278
stoichiometry: 1.0
species: 299757
type: SpeciesReference

299453
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ACTG1
type: Species

019860
stoichiometry: 1.0
species: 298863
type: SpeciesReference

300314
modifier: 025479
modifier: 025467
product: 025455
reactant: 025443
notes: (from REACTOME) PMID: 8515817 phosphorylation and inactivation of Wee1 kinase PMID: 15070733 PMID: 7681363 (yeast) PMID: 9268380 Cyclin B phosphorylates Myt1 in vitro
fast: false
reversible: false
type: Reaction

030997
stoichiometry: 1.0
species: 299621
type: SpeciesReference

026310
stoichiometry: 1.0
species: 299840
type: SpeciesReference

025899
stoichiometry: 1.0
species: 299840
type: SpeciesReference

021253
stoichiometry: 1.0
species: 298807
type: SpeciesReference

299042
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F6/DP1*
type: Species

300369
product: 026031
reactant: 026019
notes: PMID: 12389032
fast: false
reversible: false
type: Reaction

024362
stoichiometry: 1.0
species: 299250
type: SpeciesReference

021649
stoichiometry: 1.0
species: 299038
type: SpeciesReference

022269
stoichiometry: 1.0
species: 299108
type: SpeciesReference

300698
product: 028711
reactant: 028699
notes: Notes by CellDesigner PMID: 16144839
fast: false
reversible: false
type: Reaction

027343
stoichiometry: 1.0
species: 299378
type: SpeciesReference

301351
product: 034671
reactant: 034658
fast: false
reversible: false
type: Reaction

023366
stoichiometry: 1.0
species: 299180
type: SpeciesReference

299084
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin D1*
type: Species

027943
stoichiometry: 1.0
species: 299512
type: SpeciesReference

301038
product: 031645
reactant: 031633
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

022334
stoichiometry: 1.0
species: 299106
type: SpeciesReference

026923
stoichiometry: 1.0
species: 299840
type: SpeciesReference

034495
stoichiometry: 1.0
species: 298906
type: SpeciesReference

024914
stoichiometry: 1.0
species: 299790
type: SpeciesReference

300099
product: 022898
reactant: 022886
notes: PMID: 10373560 The NES (nuclear export signal) of the cyclin B allows its active export. Export via the CRM1 complex, seems to need GTPaseRan/TC4 PMID: 9679058 (ref REACTOME) PMID: 9670027 PMID: 9679058
fast: false
reversible: false
type: Reaction

298919
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: DP2*
type: Species

028243
stoichiometry: 1.0
species: 299313
type: SpeciesReference

026791
stoichiometry: 1.0
species: 299492
type: SpeciesReference

027667
stoichiometry: 1.0
species: 299840
type: SpeciesReference

026527
stoichiometry: 1.0
species: 299598
type: SpeciesReference

299678
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ECE1
type: Species

034544
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300005
modifier: 021841
product: 021829
reactant: 021817
reactant: 021805
notes: sequestration of CDK4 to prevent its association with Cyclins D and RB phosphorylation. PMID: 11960696 (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false
type: Reaction

030248
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300947
product: 030781
reactant: 030769
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

300312
product: 025431
reactant: 025419
notes: Nuclear translocation during the G2 to M transition. PMID: 8348613 Translocation via the proteins of the 14-3-3 group. PMID: 12814430 (ref REACTOME) PMID: 9836640 PMID: 9889122 (from REACTOME) PMID: 11063929
fast: false
reversible: false
type: Reaction

300616
product: 028015
reactant: 028003
notes: Notes by CellDesigner PMID: 12771133 reaction: direct
fast: false
reversible: false
type: Reaction

020460
stoichiometry: 1.0
species: 298807
type: SpeciesReference

300297
product: 025275
product: 025263
reactant: 025251
notes: MDM2 = ubiquitin-ligase, regulates p53 stability: induice its degradation via the proteasome. PMID: 15024084
fast: false
reversible: false
type: Reaction

299451
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ACTN4
type: Species

301250
product: 033638
reactant: 033626
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

299002
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EHMT1
type: Species

025119
stoichiometry: 1.0
species: 299304
type: SpeciesReference

025335
stoichiometry: 1.0
species: 299821
type: SpeciesReference

024218
stoichiometry: 1.0
species: 299213
type: SpeciesReference

023858
stoichiometry: 1.0
species: 299207
type: SpeciesReference

025947
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299009
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MAX
type: Species

034322
stoichiometry: 1.0
species: 299313
type: SpeciesReference

300613
product: 027991
reactant: 027979
notes: PMID: 12771133
fast: false
reversible: false
type: Reaction

032594
stoichiometry: 1.0
species: 299840
type: SpeciesReference

027307
stoichiometry: 1.0
species: 299840
type: SpeciesReference

026411
stoichiometry: 1.0
species: 299840
type: SpeciesReference

020617
stoichiometry: 1.0
species: 298933
type: SpeciesReference

020280
stoichiometry: 1.0
species: 298851
type: SpeciesReference

021025
stoichiometry: 1.0
species: 298931
type: SpeciesReference

299748
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TP53BP2
type: Species

301036
product: 031621
reactant: 031609
notes: Notes by CellDesigner PMID: 15105433 reaction: directPMID: 15510213
fast: false
reversible: false
type: Reaction

299853
product: 019884
reactant: 019872
reactant: 019860
fast: false
reversible: false
type: Reaction

299086
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: a838_degraded
type: Species

299457
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CSDA
type: Species

030889
stoichiometry: 1.0
species: 298923
type: SpeciesReference

030310
stoichiometry: 1.0
species: 299367
type: SpeciesReference

031621
stoichiometry: 1.0
species: 299529
type: SpeciesReference

032702
stoichiometry: 1.0
species: 299701
type: SpeciesReference

033710
stoichiometry: 1.0
species: 299816
type: SpeciesReference

023702
stoichiometry: 1.0
species: 299088
type: SpeciesReference

299788
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PURALPHA
type: Species

027079
stoichiometry: 1.0
species: 299394
type: SpeciesReference

301057
product: 031813
reactant: 031801
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

300366
product: 026007
reactant: 025995
notes: PMID: 12389032
fast: false
reversible: false
type: Reaction

031081
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300003
product: 021793
reactant: 021781
reactant: 021769
notes: PMID: 11171983
fast: false
reversible: false
type: Reaction

299049
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: SERTAD1
type: Species

024890
stoichiometry: 1.0
species: 299799
type: SpeciesReference

300691
product: 028663
reactant: 028651
notes: Notes by CellDesigner PMID: 12077144
fast: false
reversible: false
type: Reaction

024998
stoichiometry: 1.0
species: 299278
type: SpeciesReference

300094
modifier: 022838
product: 022826
reactant: 022814
notes: CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin. PMID: 12814430 WEE1 allows CDC2 to stay in an inactive state after its translocation during G2. PMID: 10373560 PMID: 8348613 PMID: 9001210 (ref REACTOME) PMID: 1384126 PMID: 15037762
fast: false
reversible: false
type: Reaction

033650
stoichiometry: 1.0
species: 298923
type: SpeciesReference

026247
stoichiometry: 1.0
species: 299507
type: SpeciesReference

301141
product: 032630
reactant: 032618
notes: PMID: 10733529 PMID: 14688249 PMID: 15574595
fast: false
reversible: false
type: Reaction

300825
product: 029875
reactant: 029863
notes: Notes by CellDesigner PMID: 12665581
fast: false
reversible: false
type: Reaction

299007
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MGA
type: Species

021145
stoichiometry: 1.0
species: 298989
type: SpeciesReference

031213
stoichiometry: 1.0
species: 299360
type: SpeciesReference

021709
stoichiometry: 1.0
species: 299013
type: SpeciesReference

029551
stoichiometry: 1.0
species: 299838
type: SpeciesReference

028999
stoichiometry: 1.0
species: 299483
type: SpeciesReference

023210
stoichiometry: 1.0
species: 299166
type: SpeciesReference

034178
stoichiometry: 1.0
species: 299840
type: SpeciesReference

028039
stoichiometry: 1.0
species: 299427
type: SpeciesReference

034202
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300581
product: 027703
reactant: 027691
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

301034
product: 031597
reactant: 031585
notes: Notes by CellDesigner PMID: 12139485 reaction: direct
fast: false
reversible: false
type: Reaction

024254
stoichiometry: 1.0
species: 299237
type: SpeciesReference

299088
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p27Kip1*
type: Species

300317
reactant: 025491
modifier: 025527
notes: Protein stabilized by phosphorylation. PMID: 15838517 PMID: 15140942
reversible: false
product: 025515
fast: false
modifier: 025539
product: 025503
type: Reaction

030139
stoichiometry: 1.0
species: 299658
type: SpeciesReference

298998
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EPC1
type: Species

031297
stoichiometry: 1.0
species: 298923
type: SpeciesReference

030949
stoichiometry: 1.0
species: 299412
type: SpeciesReference

032894
stoichiometry: 1.0
species: 299730
type: SpeciesReference

299850
product: 019848
reactant: 019836
reactant: 019823
fast: false
reversible: false
type: Reaction

299455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: ESR1
type: Species

022561
stoichiometry: 1.0
species: 299106
type: SpeciesReference

299786
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDCA7
type: Species

020545
stoichiometry: 1.0
species: 298933
type: SpeciesReference

298915
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: SWI/SNF
type: Species

032234
stoichiometry: 1.0
species: 299840
type: SpeciesReference

025083
stoichiometry: 1.0
species: 298849
type: SpeciesReference

300541
product: 027319
reactant: 027307
notes: PMID: 15175242 PMID: 11034215
fast: false
reversible: false
type: Reaction

034238
stoichiometry: 1.0
species: 299674
type: SpeciesReference

031513
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300364
product: 025983
reactant: 025971
notes: PMID: 12389032
fast: false
reversible: false
type: Reaction

301059
product: 031837
reactant: 031825
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

030285
stoichiometry: 1.0
species: 299634
type: SpeciesReference

029815
stoichiometry: 1.0
species: 299838
type: SpeciesReference

028135
stoichiometry: 1.0
species: 299600
type: SpeciesReference

021541
stoichiometry: 1.0
species: 298994
type: SpeciesReference

299745
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TP53INP1
type: Species

022097
stoichiometry: 1.0
species: 299119
type: SpeciesReference

300428
product: 026551
reactant: 026539
notes: PMID: 16158053
fast: false
reversible: false
type: Reaction

025851
stoichiometry: 1.0
species: 299840
type: SpeciesReference

030589
stoichiometry: 1.0
species: 299632
type: SpeciesReference

299195
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: GSK3B
type: Species

020352
stoichiometry: 1.0
species: 298877
type: SpeciesReference

025251
stoichiometry: 1.0
species: 299330
type: SpeciesReference

033230
stoichiometry: 1.0
species: 299754
type: SpeciesReference

300000
product: 021757
reactant: 021745
reactant: 021733
notes: PMID: 15536069
fast: false
reversible: false
type: Reaction

031597
stoichiometry: 1.0
species: 299572
type: SpeciesReference

027775
stoichiometry: 1.0
species: 299556
type: SpeciesReference

029131
stoichiometry: 1.0
species: 299840
type: SpeciesReference

027871
stoichiometry: 1.0
species: 299468
type: SpeciesReference

300718
product: 028903
reactant: 028891
notes: Notes by CellDesigner PMID: 14990995 reaction: direct
fast: false
reversible: false
type: Reaction

030528
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299157
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*/CDC2
type: Species

025191
stoichiometry: 1.0
species: 298897
type: SpeciesReference

023570
stoichiometry: 1.0
species: 299148
type: SpeciesReference

028435
stoichiometry: 1.0
species: 299313
type: SpeciesReference

032810
stoichiometry: 1.0
species: 298923
type: SpeciesReference

021481
stoichiometry: 1.0
species: 299016
type: SpeciesReference

301296
product: 034070
reactant: 034058
fast: false
reversible: false
type: Reaction

032402
stoichiometry: 1.0
species: 299840
type: SpeciesReference

029851
stoichiometry: 1.0
species: 299689
type: SpeciesReference

022910
stoichiometry: 1.0
species: 299132
type: SpeciesReference

299743
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: THEM2
type: Species

298992
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin C*/CDK3
type: Species

301206
product: 033230
reactant: 033218
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

028843
stoichiometry: 1.0
species: 299843
type: SpeciesReference

024638
stoichiometry: 1.0
species: 299825
type: SpeciesReference

298951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p130*/E2F4/DP2*/_br_Sin3B/HDAC1/SUV39H1
type: Species

300362
product: 025959
reactant: 025947
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

020509
stoichiometry: 1.0
species: 298910
type: SpeciesReference

029419
stoichiometry: 1.0
species: 299556
type: SpeciesReference

022220
stoichiometry: 1.0
species: 299097
type: SpeciesReference

034022
stoichiometry: 1.0
species: 299810
type: SpeciesReference

299945
product: 021025
reversible: false
product: 021037
product: 021001
product: 021049
product: 021013
notes: PMID: 12006580 PMID: 15769944
reactant: 020989
fast: false
type: Reaction

301318
product: 034286
reactant: 034274
notes: PMID: 15574595
fast: false
reversible: false
type: Reaction

299808
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p19INK4d*
type: Species

300505
product: 027007
reactant: 026995
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

022513
stoichiometry: 1.0
species: 299115
type: SpeciesReference

299117
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin D1*/CDK4
type: Species

023198
stoichiometry: 1.0
species: 299164
type: SpeciesReference

301356
product: 034697
reactant: 034684
fast: false
reversible: false
type: Reaction

032390
stoichiometry: 1.0
species: 299708
type: SpeciesReference

021697
stoichiometry: 1.0
species: 299000
type: SpeciesReference

300091
modifier: 022802
product: 022790
reactant: 022778
notes: dephosphorylation of CDC2 induce its activation PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false
type: Reaction

026398
stoichiometry: 1.0
species: 299503
type: SpeciesReference

026285
stoichiometry: 1.0
species: 299840
type: SpeciesReference

023810
stoichiometry: 1.0
species: 298960
type: SpeciesReference

032126
stoichiometry: 1.0
species: 299479
type: SpeciesReference

020653
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299155
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC2
type: Species

031837
stoichiometry: 1.0
species: 299369
type: SpeciesReference

301298
product: 034094
reactant: 034082
notes: PMID: 15574595
fast: false
reversible: false
type: Reaction

298912
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p107*
type: Species

032786
stoichiometry: 1.0
species: 298923
type: SpeciesReference

031982
stoichiometry: 1.0
species: 299567
type: SpeciesReference

298859
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: TFIIH*
type: Species

027607
stoichiometry: 1.0
species: 299812
type: SpeciesReference

020016
stoichiometry: 1.0
species: 298868
type: SpeciesReference

299741
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: STMN1
type: Species

300425
product: 026527
reactant: 026515
notes: PMID: 11564866 PMID: 8441401
fast: false
reversible: false
type: Reaction

031033
stoichiometry: 1.0
species: 298923
type: SpeciesReference

301358
product: 034723
reactant: 034710
fast: false
reversible: false
type: Reaction

300584
product: 027727
reactant: 027715
fast: false
reversible: false
type: Reaction

033542
stoichiometry: 1.0
species: 299772
type: SpeciesReference

021601
stoichiometry: 1.0
species: 299033
type: SpeciesReference

299198
notes: UNIPROT: P31749 Q6ZS54 P55010 Q9BV07 Q9BWB6 Q6ZMW5 O15040 Q8TBZ3 P31749
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: AKT1
type: Species

298953
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p130*/E2F4/DP2*/_br_Sin3B/HDAC1/SUV39H1
type: Species

299895
modifier: 020400
product: 020388
reactant: 020376
notes: Phosphorylation at the Ser-403 in S phase by the TFIIH kinase targets E2F1 for its rapid ubiquitination and degradation through the ubiquitin-proteasome pathway. PMID: 15123636 Phosphorylation at Ser-403 and Thr-433 by the basal TF TFHII triggers E2F1 degradation. PMID: 16213134
fast: false
reversible: false
type: Reaction

301316
product: 034262
reactant: 034250
notes: PMID: 16135806
fast: false
reversible: false
type: Reaction

300503
product: 026983
reactant: 026971
notes: PMID: 15706352
fast: false
reversible: false
type: Reaction

299115
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC37/HSP90
type: Species

298994
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F6
type: Species

021817
stoichiometry: 1.0
species: 299051
type: SpeciesReference

299346
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F7
type: Species

030043
stoichiometry: 1.0
species: 299812
type: SpeciesReference

299191
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*
type: Species

027031
stoichiometry: 1.0
species: 299398
type: SpeciesReference

033758
stoichiometry: 1.0
species: 299783
type: SpeciesReference

022489
stoichiometry: 1.0
species: 299110
type: SpeciesReference

031669
stoichiometry: 1.0
species: 299527
type: SpeciesReference

030841
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299343
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F6
type: Species

300187
product: 023930
reactant: 023918
notes: Degradation via the ubiquitin/proteasome system. PMID: 8861947
fast: false
reversible: false
type: Reaction

033122
stoichiometry: 1.0
species: 299838
type: SpeciesReference

301201
product: 033206
reactant: 033194
notes: PMID: 12838312
fast: false
reversible: false
type: Reaction

032174
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299805
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p18INK4c*
type: Species

298910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p107*
type: Species

021205
stoichiometry: 1.0
species: 298980
type: SpeciesReference

029287
stoichiometry: 1.0
species: 299838
type: SpeciesReference

021781
stoichiometry: 1.0
species: 299029
type: SpeciesReference

022621
stoichiometry: 1.0
species: 299825
type: SpeciesReference

020064
stoichiometry: 1.0
species: 298874
type: SpeciesReference

026815
stoichiometry: 1.0
species: 299490
type: SpeciesReference

299000
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: EZH2
type: Species

299113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK4/CDC37
type: Species

300423
product: 026502
reactant: 026489
notes: PMID: 12909625
fast: false
reversible: false
type: Reaction

027835
stoichiometry: 1.0
species: 299309
type: SpeciesReference

031105
stoichiometry: 1.0
species: 298923
type: SpeciesReference

030463
stoichiometry: 1.0
species: 299556
type: SpeciesReference

301291
product: 034022
reactant: 034010
notes: PMID: 12368233
fast: false
reversible: false
type: Reaction

299567
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SIP*
type: Species

299941
modifier: 020953
type: Reaction
modifier: 020941
product: 020917
notes: PMID: 12006580
modifier: 020929
modifier: 020965
reversible: false
reactant: 020905
fast: false
modifier: 020977

030901
stoichiometry: 1.0
species: 299505
type: SpeciesReference

299193
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2
type: Species

299341
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F3
type: Species

031945
stoichiometry: 1.0
species: 298923
type: SpeciesReference

028543
stoichiometry: 1.0
species: 299559
type: SpeciesReference

033338
stoichiometry: 1.0
species: 298923
type: SpeciesReference

028939
stoichiometry: 1.0
species: 299843
type: SpeciesReference

024542
stoichiometry: 1.0
species: 299259
type: SpeciesReference

034723
stoichiometry: 1.0
species: 299311
type: SpeciesReference

022790
stoichiometry: 1.0
species: 299157
type: SpeciesReference

025623
stoichiometry: 1.0
species: 299790
type: SpeciesReference

034619
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299898
product: 020424
reactant: 020412
notes: Degradation depends upon ubiquitination. E3: F-box protein p45Skp2 PMID: 16213134
fast: false
reversible: false
type: Reaction

033602
stoichiometry: 1.0
species: 299840
type: SpeciesReference

021589
stoichiometry: 1.0
species: 299002
type: SpeciesReference

034130
stoichiometry: 1.0
species: 299840
type: SpeciesReference

029599
stoichiometry: 1.0
species: 299838
type: SpeciesReference

299858
modifier: 019920
modifier: 019932
notes: Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel. PMID: 15126619 Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases. PMID: 15123636 Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP. PMID: 10753885
reactant: 019896
fast: false
product: 019908
modifier: 019944
reversible: false
type: Reaction

029635
stoichiometry: 1.0
species: 299412
type: SpeciesReference

300107
modifier: 023006
product: 022994
reactant: 022982
notes: Dephosphorylation of CDC2 induces its activation. PMID: 10373560 PMID: 8348613 PMID: 12814430
fast: false
reversible: false
type: Reaction

300588
product: 027751
reactant: 027739
notes: Notes by CellDesigner PMID: 14633988
fast: false
reversible: false
type: Reaction

023258
stoichiometry: 1.0
species: 299164
type: SpeciesReference

019908
stoichiometry: 1.0
species: 298879
type: SpeciesReference

300421
product: 026476
reactant: 026463
notes: PMID: 10998368
fast: false
reversible: false
type: Reaction

033698
stoichiometry: 1.0
species: 299313
type: SpeciesReference

301293
product: 034046
reactant: 034034
notes: PMID: 12368233
fast: false
reversible: false
type: Reaction

026563
stoichiometry: 1.0
species: 299840
type: SpeciesReference

026043
stoichiometry: 1.0
species: 299840
type: SpeciesReference

034058
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299362
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: KPNA2
type: Species

034697
stoichiometry: 1.0
species: 299663
type: SpeciesReference

022730
stoichiometry: 1.0
species: 299162
type: SpeciesReference

020424
stoichiometry: 1.0
species: 298861
type: SpeciesReference

299410
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: GMNN
type: Species

033038
stoichiometry: 1.0
species: 299743
type: SpeciesReference

299810
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TERT
type: Species

299257
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a701_degraded
type: Species

023990
stoichiometry: 1.0
species: 299213
type: SpeciesReference

301320
product: 034310
reactant: 034298
notes: PMID: 10733529 PMID: 15014447
fast: false
reversible: false
type: Reaction

022706
stoichiometry: 1.0
species: 299137
type: SpeciesReference

300806
product: 029707
reactant: 029695
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

300790
product: 029563
reactant: 029551
notes: Notes by CellDesigner PMID: 10733529 PMID: 15014447 reaction: direct
fast: false
reversible: false
type: Reaction

299987
product: 021601
reactant: 021589
reactant: 021577
reactant: 021565
notes: PMID: 12004135 PMID: 15126619
fast: false
reversible: false
type: Reaction

028099
stoichiometry: 1.0
species: 299313
type: SpeciesReference

298800
constant: true
size: NaN
spatial dimensions: 3.0
name: cell
type: Compartment

300185
modifier: 023906
product: 023894
reactant: 023882
notes: PMID: 11355576
fast: false
reversible: false
type: Reaction

030745
stoichiometry: 1.0
species: 298923
type: SpeciesReference

033350
stoichiometry: 1.0
species: 299765
type: SpeciesReference

030685
stoichiometry: 1.0
species: 299628
type: SpeciesReference

025034
stoichiometry: 1.0
species: 298847
type: SpeciesReference

300131
product: 023246
reactant: 023234
notes: PMID: 10373560 PMID: 10395539 (from REACTOME) PMID: 11063929
fast: false
reversible: false
type: Reaction

300244
product: 024614
reactant: 024602
reactant: 024590
notes: 12836612
fast: false
reversible: false
type: Reaction

299512
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BRCA1
type: Species

300918
product: 030565
reactant: 030553
notes: Notes by CellDesigner PMID: 16144839PMID: 14990995
fast: false
reversible: false
type: Reaction

298881
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*/PCAF
type: Species

027091
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300578
product: 027679
reactant: 027667
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

020160
stoichiometry: 1.0
species: 298899
type: SpeciesReference

033014
stoichiometry: 1.0
species: 299741
type: SpeciesReference

028651
stoichiometry: 1.0
species: 299843
type: SpeciesReference

022170
stoichiometry: 1.0
species: 299095
type: SpeciesReference

300750
product: 029179
reactant: 029167
notes: Notes by CellDesigner PMID: 12527885
fast: false
reversible: false
type: Reaction

300182
product: 023870
product: 023858
reactant: 023846
notes: PMID: 8861947
fast: false
reversible: false
type: Reaction

031069
stoichiometry: 1.0
species: 299615
type: SpeciesReference

299364
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDC20
type: Species

298840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: ATR
type: Species

299812
notes: also p107*
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RBL1
type: Species

300644
product: 028207
reactant: 028195
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

299563
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CASP7
type: Species

301322
product: 034334
reactant: 034322
notes: PMID: 15574595
fast: false
reversible: false
type: Reaction

300539
product: 027295
reactant: 027283
notes: PMID: 12665581
fast: false
reversible: false
type: Reaction

299259
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: p27Kip1*
type: Species

299412
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: EZH2
type: Species

299298
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p53*/MDM2
type: Species

299626
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: DRF1
type: Species

034645
stoichiometry: 1.0
species: 299313
type: SpeciesReference

022682
stoichiometry: 1.0
species: 298971
type: SpeciesReference

020220
stoichiometry: 1.0
species: 299295
type: SpeciesReference

300808
product: 029731
reactant: 029719
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

025791
stoichiometry: 1.0
species: 299446
type: SpeciesReference

034582
stoichiometry: 1.0
species: 299337
type: SpeciesReference

300058
product: 022439
reactant: 022426
reactant: 022413
notes: PMID: 10385618 PMID: 10498883
fast: false
reversible: false
type: Reaction

300432
product: 026575
reactant: 026563
notes: PMID: 15867357
fast: false
reversible: false
type: Reaction

300710
product: 028831
reactant: 028819
notes: Notes by CellDesigner PMID: 14532106
fast: false
reversible: false
type: Reaction

031789
stoichiometry: 1.0
species: 299520
type: SpeciesReference

026671
stoichiometry: 1.0
species: 299346
type: SpeciesReference

029311
stoichiometry: 1.0
species: 299838
type: SpeciesReference

028387
stoichiometry: 1.0
species: 299313
type: SpeciesReference

300133
product: 023270
reactant: 023258
notes: PMID: 10373560 The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and could need the GTPaseRan/TC4. PMID: 9679058 (ref REACTOME) PMID: 9670027 PMID: 9679058
fast: false
reversible: false
type: Reaction

033182
stoichiometry: 1.0
species: 299750
type: SpeciesReference

029791
stoichiometry: 1.0
species: 299838
type: SpeciesReference

024854
stoichiometry: 1.0
species: 298847
type: SpeciesReference

032486
stoichiometry: 1.0
species: 299814
type: SpeciesReference

021733
stoichiometry: 1.0
species: 299018
type: SpeciesReference

033410
stoichiometry: 1.0
species: 299840
type: SpeciesReference

020725
stoichiometry: 1.0
species: 298874
type: SpeciesReference

300247
product: 024650
reactant: 024638
reactant: 024626
notes: 12836612
fast: false
reversible: false
type: Reaction

298842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CHEK2
type: Species

299200
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK2
type: Species

020112
stoichiometry: 1.0
species: 298870
type: SpeciesReference

024650
stoichiometry: 1.0
species: 299268
type: SpeciesReference

032942
stoichiometry: 1.0
species: 299736
type: SpeciesReference

032042
stoichiometry: 1.0
species: 299311
type: SpeciesReference

299309
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F5
type: Species

298883
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: pRB*/E2F1/DP1*
type: Species

299628
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CSTF3
type: Species

022413
stoichiometry: 1.0
species: 299079
type: SpeciesReference

299561
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CASP8
type: Species

301325
modifier: 034371
product: 034359
reactant: 034347
notes: PMID: 15798220
fast: false
reversible: false
type: Reaction

024746
stoichiometry: 1.0
species: 299284
type: SpeciesReference

027691
stoichiometry: 1.0
species: 299840
type: SpeciesReference

025431
stoichiometry: 1.0
species: 299184
type: SpeciesReference

300712
product: 028855
reactant: 028843
notes: Notes by CellDesigner PMID: 14532106
fast: false
reversible: false
type: Reaction

030175
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299936
product: 020893
reactant: 020881
reactant: 020869
reactant: 020857
notes: HDAC1 and Sin3B associate to the promoteurs via E2F4 and p130/p107 PMID: 11959842 HDAC1 and SUV39H1 associate to the promoteurs via E2F4 and p130/p107 PMID: 15769944
fast: false
reversible: false
type: Reaction

301099
product: 032246
reactant: 032234
notes: PMID: 12625370
fast: false
reversible: false
type: Reaction

033074
stoichiometry: 1.0
species: 299843
type: SpeciesReference

301219
product: 033374
reactant: 033362
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

029503
stoichiometry: 1.0
species: 299838
type: SpeciesReference

023954
stoichiometry: 1.0
species: 299209
type: SpeciesReference

023102
stoichiometry: 1.0
species: 299157
type: SpeciesReference

300795
product: 029611
reactant: 029599
notes: Notes by CellDesigner PMID: 14532106 reaction: direct
fast: false
reversible: false
type: Reaction

031897
stoichiometry: 1.0
species: 298923
type: SpeciesReference

298805
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: APC/CDC20
type: Species

300866
product: 030043
reactant: 030031
notes: PMID: 10766737
fast: false
reversible: false
type: Reaction

300753
product: 029203
reactant: 029191
notes: Notes by CellDesigner PMID: 15271987 reaction: direct
fast: false
reversible: false
type: Reaction

030637
stoichiometry: 1.0
species: 299654
type: SpeciesReference

299890
product: 020328
product: 020316
reactant: 020304
fast: false
reversible: false
type: Reaction

300801
product: 029659
reactant: 029647
notes: Notes by CellDesigner PMID: 15574337 reaction: direct
fast: false
reversible: false
type: Reaction

030360
stoichiometry: 1.0
species: 299432
type: SpeciesReference

021421
stoichiometry: 1.0
species: 299029
type: SpeciesReference

300249
product: 024686
reactant: 024674
reactant: 024662
notes: PMID: 15798220
fast: false
reversible: false
type: Reaction

299360
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM6
type: Species

029755
stoichiometry: 1.0
species: 299683
type: SpeciesReference

300715
product: 028879
reactant: 028867
notes: Notes by CellDesigner PMID: 15574337 reaction: direct
fast: false
reversible: false
type: Reaction

026635
stoichiometry: 1.0
species: 299840
type: SpeciesReference

022814
stoichiometry: 1.0
species: 299157
type: SpeciesReference

300053
product: 022400
reactant: 022387
reactant: 022373
notes: PMID: 10385618 PMID: 10498883
fast: false
reversible: false
type: Reaction

298802
constant: true
size: NaN
spatial dimensions: 3.0
name: genes
type: Compartment

026151
stoichiometry: 1.0
species: 299430
type: SpeciesReference

300961
product: 030877
reactant: 030865
notes: Notes by CellDesigner PMID: 12789259 reaction: direct
fast: false
reversible: false
type: Reaction

028723
stoichiometry: 1.0
species: 299843
type: SpeciesReference

299188
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC25C
type: Species

300792
product: 029587
reactant: 029575
notes: Notes by CellDesigner PMID: 10766737 PMID: 14576826 reaction: direct
fast: false
reversible: false
type: Reaction

299202
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a852_degraded
type: Species

298967
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK6/CDKN1A
type: Species

299416
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: EED
type: Species

023882
stoichiometry: 1.0
species: 299200
type: SpeciesReference

299893
modifier: 020364
product: 020352
reactant: 020340
notes: PMID: 10753885
fast: false
reversible: false
type: Reaction

031465
stoichiometry: 1.0
species: 298923
type: SpeciesReference

033974
stoichiometry: 1.0
species: 299810
type: SpeciesReference

301259
product: 033710
reactant: 033698
notes: PMID: 16792505
fast: false
reversible: false
type: Reaction

033302
stoichiometry: 1.0
species: 299761
type: SpeciesReference

031189
stoichiometry: 1.0
species: 299548
type: SpeciesReference

021889
stoichiometry: 1.0
species: 299056
type: SpeciesReference

024338
stoichiometry: 1.0
species: 299246
type: SpeciesReference

028339
stoichiometry: 1.0
species: 299313
type: SpeciesReference

301097
product: 032222
reactant: 032210
fast: false
reversible: false
type: Reaction

032558
stoichiometry: 1.0
species: 299678
type: SpeciesReference

031717
stoichiometry: 1.0
species: 299525
type: SpeciesReference

029467
stoichiometry: 1.0
species: 299507
type: SpeciesReference

299510
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CASP9
type: Species

028495
stoichiometry: 1.0
species: 299516
type: SpeciesReference

300803
product: 029683
reactant: 029671
notes: Notes by CellDesigner PMID: 14990995
fast: false
reversible: false
type: Reaction

300868
product: 030067
reactant: 030055
notes: Notes by CellDesigner PMID: 15014447 reaction: direct
fast: false
reversible: false
type: Reaction

023558
stoichiometry: 1.0
species: 299144
type: SpeciesReference

025755
stoichiometry: 1.0
species: 299840
type: SpeciesReference

032330
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300756
product: 029227
reactant: 029215
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

300911
product: 030489
reactant: 030476
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

299418
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: Cox IV*
type: Species

021109
stoichiometry: 1.0
species: 298956
type: SpeciesReference

030007
stoichiometry: 1.0
species: 299838
type: SpeciesReference

034118
stoichiometry: 1.0
species: 299479
type: SpeciesReference

029719
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300963
product: 030901
reactant: 030889
notes: Notes by CellDesigner PMID: 16144839PMID: 14990995
fast: false
reversible: false
type: Reaction

299459
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RAD51AP1
type: Species

026115
stoichiometry: 1.0
species: 299840
type: SpeciesReference

033938
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300138
modifier: 023306
product: 023294
reactant: 023282
notes: Phosphorylation only when CDC2 is bound to the cyclin D. PMID: 10373560 PMID: 9001210 PMID: 12814430
fast: false
reversible: false
type: Reaction

033398
stoichiometry: 1.0
species: 299765
type: SpeciesReference

030961
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300861
product: 029995
reactant: 029983
notes: Notes by CellDesigner PMID: 12110166
fast: false
reversible: false
type: Reaction

030211
stoichiometry: 1.0
species: 299574
type: SpeciesReference

299369
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: RBBP8
type: Species

299671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: Cyclin E*
type: Species

031357
stoichiometry: 1.0
species: 299537
type: SpeciesReference

298886
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin A2*/CDK2
type: Species

030437
stoichiometry: 1.0
species: 299427
type: SpeciesReference

034274
stoichiometry: 1.0
species: 299313
type: SpeciesReference

022778
stoichiometry: 1.0
species: 299162
type: SpeciesReference

301145
product: 032678
reactant: 032666
notes: PMID: 16325355
fast: false
reversible: false
type: Reaction

028951
stoichiometry: 1.0
species: 299554
type: SpeciesReference

030323
stoichiometry: 1.0
species: 298923
type: SpeciesReference

028051
stoichiometry: 1.0
species: 299313
type: SpeciesReference

300532
product: 027247
reactant: 027235
notes: PMID: 12438307
fast: false
reversible: false
type: Reaction

301095
product: 032198
reactant: 032186
fast: false
reversible: false
type: Reaction

023774
stoichiometry: 1.0
species: 298958
type: SpeciesReference

300290
product: 025215
reactant: 025203
notes: E2F1 sequestrated by ARF in the nucleolus. PMID: 16135794 PMID: 12446760
fast: false
reversible: false
type: Reaction

020905
stoichiometry: 1.0
species: 298953
type: SpeciesReference

299307
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298791
name: E2F1/p14ARF*
type: Species

300758
product: 029251
reactant: 029239
notes: PMID: 15510213 PMID: 10733529
fast: false
reversible: false
type: Reaction

301256
product: 033686
reactant: 033674
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

301103
product: 032270
reactant: 032258
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

031741
stoichiometry: 1.0
species: 299523
type: SpeciesReference

024122
stoichiometry: 1.0
species: 299191
type: SpeciesReference

301031
product: 031573
reactant: 031561
notes: Notes by CellDesigner PMID: 15510213 reaction: direct
fast: false
reversible: false
type: Reaction

029359
stoichiometry: 1.0
species: 299838
type: SpeciesReference

299079
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: HSP90
type: Species

300965
product: 030925
reactant: 030913
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

032666
stoichiometry: 1.0
species: 299843
type: SpeciesReference

033458
stoichiometry: 1.0
species: 299313
type: SpeciesReference

028699
stoichiometry: 1.0
species: 299843
type: SpeciesReference

027187
stoichiometry: 1.0
species: 299840
type: SpeciesReference

298807
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: HDAC1
type: Species

300864
product: 030019
reactant: 030007
notes: Notes by CellDesigner PMID: 15731768
fast: false
reversible: false
type: Reaction

299783
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDCA4
type: Species

026851
stoichiometry: 1.0
species: 299840
type: SpeciesReference

027739
stoichiometry: 1.0
species: 299663
type: SpeciesReference

298888
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F1/DP1*
type: Species

021097
stoichiometry: 1.0
species: 298908
type: SpeciesReference

023594
stoichiometry: 1.0
species: 299184
type: SpeciesReference

027427
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300823
product: 029851
reactant: 029839
notes: Notes by CellDesigner PMID: 12438307 reaction: direct
fast: false
reversible: false
type: Reaction

301143
product: 032654
reactant: 032642
notes: PMID: 17482685
fast: false
reversible: false
type: Reaction

299982
product: 021517
reactant: 021505
reactant: 021493
notes: PMID: 15126619
fast: false
reversible: false
type: Reaction

021913
stoichiometry: 1.0
species: 299060
type: SpeciesReference

299250
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin H*
type: Species

300530
product: 027223
reactant: 027211
notes: PMID: 11564866 PMID: 90001421
fast: false
reversible: false
type: Reaction

020268
stoichiometry: 1.0
species: 298863
type: SpeciesReference

298790
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

034433
stoichiometry: 1.0
species: 298958
type: SpeciesReference

299674
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TP73
type: Species

023666
stoichiometry: 1.0
species: 299070
type: SpeciesReference

027127
stoichiometry: 1.0
species: 299391
type: SpeciesReference

028615
stoichiometry: 1.0
species: 299427
type: SpeciesReference

299701
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MCM8
type: Species

301092
product: 032174
reactant: 032162
fast: false
reversible: false
type: Reaction

300293
product: 025239
reactant: 025227
notes: PMID: 9819415
fast: false
reversible: false
type: Reaction

301148
product: 032702
reactant: 032690
notes: PMID: 16325355
fast: false
reversible: false
type: Reaction

300689
product: 028639
reactant: 028627
notes: Notes by CellDesigner PMID: 10766737 reaction: direct
fast: false
reversible: false
type: Reaction

300967
product: 030949
reactant: 030937
notes: Notes by CellDesigner PMID: 14532106 reaction: directPMID: 15574337
fast: false
reversible: false
type: Reaction

300200
product: 024098
reactant: 024086
reactant: 024074
notes: (ref REACTOME) PMID: 7799941
fast: false
reversible: false
type: Reaction

022023
stoichiometry: 1.0
species: 299075
type: SpeciesReference

299621
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FGFR1
type: Species

019787
stoichiometry: 1.0
species: 298827
type: SpeciesReference

301052
product: 031789
reactant: 031777
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

299516
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BIRC5
type: Species

299984
product: 021553
reactant: 021541
reactant: 021529
fast: false
reversible: false
type: Reaction

027463
stoichiometry: 1.0
species: 299596
type: SpeciesReference

299302
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298791
name: p14ARF*/MDM2
type: Species

300649
product: 028255
reactant: 028243
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

300914
product: 030515
reactant: 030502
notes: Notes by CellDesigner PMID: 11799067 reaction: direct
fast: false
reversible: false
type: Reaction

300536
product: 027271
reactant: 027259
notes: PMID: 12444919
fast: false
reversible: false
type: Reaction

027535
stoichiometry: 1.0
species: 299459
type: SpeciesReference

299252
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK7
type: Species

034384
stoichiometry: 1.0
species: 298910
type: SpeciesReference

024698
stoichiometry: 1.0
species: 299335
type: SpeciesReference

301108
product: 032318
reactant: 032306
notes: PMID: 17482685
fast: false
reversible: false
type: Reaction

026743
stoichiometry: 1.0
species: 299494
type: SpeciesReference

032378
stoichiometry: 1.0
species: 299840
type: SpeciesReference

020833
stoichiometry: 1.0
species: 298903
type: SpeciesReference

301252
product: 033662
reactant: 033650
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

299780
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BMI1
type: Species

032510
stoichiometry: 1.0
species: 299676
type: SpeciesReference

299255
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK7/cyclin H*/MNAT1
type: Species

301090
product: 032150
reactant: 032138
fast: false
reversible: false
type: Reaction

031141
stoichiometry: 1.0
species: 299550
type: SpeciesReference

299703
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: miR-17-92
type: Species

025827
stoichiometry: 1.0
species: 299840
type: SpeciesReference

023510
stoichiometry: 1.0
species: 299146
type: SpeciesReference

300687
product: 028615
reactant: 028603
notes: Notes by CellDesigner PMID: 15510213 reaction: direct
fast: false
reversible: false
type: Reaction

028003
stoichiometry: 1.0
species: 299313
type: SpeciesReference

021469
stoichiometry: 1.0
species: 298998
type: SpeciesReference

024482
stoichiometry: 1.0
species: 299255
type: SpeciesReference

299623
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FBXO5
type: Species

300916
product: 030541
reactant: 030528
notes: Notes by CellDesigner PMID: 12077144 reaction: direct
fast: false
reversible: false
type: Reaction

298791
constant: true
size: NaN
spatial dimensions: 3.0
name: nucleole
type: Compartment

300647
product: 028231
reactant: 028219
notes: Notes by CellDesigner PMID: 15985428
fast: false
reversible: false
type: Reaction

299367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BUB1
type: Species

022207
stoichiometry: 1.0
species: 299093
type: SpeciesReference

029023
stoichiometry: 1.0
species: 299689
type: SpeciesReference

299518
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: AURKB
type: Species

299304
notes: Needs verification: which form of CDC25 gets phosphorylated on Ser216 by Chek1,2???
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC25C
type: Species

033794
stoichiometry: 1.0
species: 299838
type: SpeciesReference

301106
product: 032294
reactant: 032282
notes: PMID: 12766778
fast: false
reversible: false
type: Reaction

022886
stoichiometry: 1.0
species: 299162
type: SpeciesReference

027295
stoichiometry: 1.0
species: 299384
type: SpeciesReference

029971
stoichiometry: 1.0
species: 299481
type: SpeciesReference

026199
stoichiometry: 1.0
species: 299427
type: SpeciesReference

300323
reactant: 025551
type: Reaction
notes: Upon DNA damage, E2F is stabilized by ATM phosphorylation. PMID: 15838517 PMID: 15140942 14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. PMID: 15494392
fast: false
modifier: 025599
product: 025563
modifier: 025587
reversible: false
product: 025575

022257
stoichiometry: 1.0
species: 299104
type: SpeciesReference

027355
stoichiometry: 1.0
species: 299840
type: SpeciesReference

022060
stoichiometry: 1.0
species: 299097
type: SpeciesReference

033578
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300357
product: 025911
reactant: 025899
notes: PMID: 14684737
fast: false
reversible: false
type: Reaction

024374
stoichiometry: 1.0
species: 299252
type: SpeciesReference

299667
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TK1
type: Species

299738
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SUZ12
type: Species

026911
stoichiometry: 1.0
species: 299687
type: SpeciesReference

021265
stoichiometry: 1.0
species: 298987
type: SpeciesReference

024926
stoichiometry: 1.0
species: 299282
type: SpeciesReference

026899
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299462
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: MYBL2
type: Species

027955
stoichiometry: 1.0
species: 299313
type: SpeciesReference

301261
product: 033734
reactant: 033722
notes: PMID: 16582100
fast: false
reversible: false
type: Reaction

300203
product: 024134
reactant: 024122
reactant: 024110
fast: false
reversible: false
type: Reaction

299705
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: NRP1
type: Species

026450
stoichiometry: 1.0
species: 299457
type: SpeciesReference

300397
product: 026272
reactant: 026260
notes: PMID: 10030670
fast: false
reversible: false
type: Reaction

300285
product: 025167
reactant: 025155
notes: PMID: 12210082 PMID: 10498883
fast: false
reversible: false
type: Reaction

020472
stoichiometry: 1.0
species: 298931
type: SpeciesReference

033506
stoichiometry: 1.0
species: 299313
type: SpeciesReference

028231
stoichiometry: 1.0
species: 299687
type: SpeciesReference

299031
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: HP1gamma*/BAT8/EHMT1/_br_DP1*/MGA/E2F6/MAX
type: Species

299778
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: UXT
type: Species

026539
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300959
product: 030853
reactant: 030841
notes: Notes by CellDesigner PMID: 14532106 reaction: direct
fast: false
reversible: false
type: Reaction

034532
stoichiometry: 1.0
species: 299337
type: SpeciesReference

300017
modifier: 021999
product: 021987
reactant: 021975
reactant: 021962
notes: (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false
type: Reaction

025323
stoichiometry: 1.0
species: 299818
type: SpeciesReference

027655
stoichiometry: 1.0
species: 299589
type: SpeciesReference

022347
stoichiometry: 2.0
species: 299077
type: SpeciesReference

025935
stoichiometry: 1.0
species: 299516
type: SpeciesReference

025371
stoichiometry: 1.0
species: 299313
type: SpeciesReference

020689
stoichiometry: 1.0
species: 298926
type: SpeciesReference

025107
stoichiometry: 1.0
species: 299188
type: SpeciesReference

023846
stoichiometry: 1.0
species: 299226
type: SpeciesReference

301025
product: 031525
reactant: 031513
notes: Notes by CellDesigner PMID: 12766778 reaction: direct
fast: false
reversible: false
type: Reaction

299350
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: E2F2
type: Species

300605
product: 027919
reactant: 027907
notes: Notes by CellDesigner PMID: 12150994 reaction: direct
fast: false
reversible: false
type: Reaction

299708
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: PAC1
type: Species

020316
stoichiometry: 1.0
species: 298813
type: SpeciesReference

031429
stoichiometry: 1.0
species: 299483
type: SpeciesReference

299665
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: TP53
type: Species

300819
product: 029827
reactant: 029815
notes: Notes by CellDesigner PMID: 11564866 reaction: direct
fast: false
reversible: false
type: Reaction

300359
product: 025935
reactant: 025923
notes: PMID: 15271987
fast: false
reversible: false
type: Reaction

025683
stoichiometry: 1.0
species: 299840
type: SpeciesReference

027247
stoichiometry: 1.0
species: 299689
type: SpeciesReference

299070
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: GSK3B
type: Species

030298
stoichiometry: 1.0
species: 298923
type: SpeciesReference

028519
stoichiometry: 1.0
species: 299432
type: SpeciesReference

025215
stoichiometry: 1.0
species: 299307
type: SpeciesReference

022850
stoichiometry: 1.0
species: 299157
type: SpeciesReference

300684
product: 028591
reactant: 028579
notes: PMID: 8618861
fast: false
reversible: false
type: Reaction

028879
stoichiometry: 1.0
species: 299486
type: SpeciesReference

022994
stoichiometry: 1.0
species: 299175
type: SpeciesReference

031561
stoichiometry: 1.0
species: 298923
type: SpeciesReference

029935
stoichiometry: 1.0
species: 299838
type: SpeciesReference

300399
product: 026297
reactant: 026285
notes: PMID: 12077144
fast: false
reversible: false
type: Reaction

032270
stoichiometry: 1.0
species: 299713
type: SpeciesReference

301210
product: 033278
reactant: 033266
notes: PMID: 12838312 PMID: 15361834
fast: false
reversible: false
type: Reaction

028171
stoichiometry: 1.0
species: 299313
type: SpeciesReference

022295
stoichiometry: 1.0
species: 299101
type: SpeciesReference

299033
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/MAX/DP1*/MGA/BAT8/EHMT1
type: Species

299311
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F8
type: Species

301049
product: 031765
reactant: 031753
notes: Notes by CellDesigner PMID: 12909625 reaction: direct
fast: false
reversible: false
type: Reaction

033878
stoichiometry: 1.0
species: 299786
type: SpeciesReference

032846
stoichiometry: 1.0
species: 299730
type: SpeciesReference

301027
product: 031549
reactant: 031537
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

300206
modifier: 024170
product: 024158
reactant: 024146
notes: CDK activity activated by its phosphorylation by CAK-complex PMID: 11959850
fast: false
reversible: false
type: Reaction

034482
stoichiometry: 1.0
species: 299836
type: SpeciesReference

300326
product: 025623
reactant: 025611
notes: PMID: 9819415
fast: false
reversible: false
type: Reaction

298928
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a7_degraded
type: Species

028987
stoichiometry: 1.0
species: 299843
type: SpeciesReference

034094
stoichiometry: 1.0
species: 299667
type: SpeciesReference

034166
stoichiometry: 1.0
species: 299606
type: SpeciesReference

300813
product: 029779
reactant: 029767
notes: Notes by CellDesigner PMID: 16144839
fast: false
reversible: false
type: Reaction

026235
stoichiometry: 1.0
species: 299840
type: SpeciesReference

031201
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299466
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: HRK
type: Species

021157
stoichiometry: 1.0
species: 298980
type: SpeciesReference

300682
product: 028567
reactant: 028555
notes: Notes by CellDesigner PMID: 12611887
fast: false
reversible: false
type: Reaction

024266
stoichiometry: 1.0
species: 299142
type: SpeciesReference

034214
stoichiometry: 1.0
species: 299674
type: SpeciesReference

020533
stoichiometry: 1.0
species: 298949
type: SpeciesReference

022573
stoichiometry: 1.0
species: 299084
type: SpeciesReference

299774
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: WDR36
type: Species

025071
stoichiometry: 1.0
species: 299790
type: SpeciesReference

299035
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP1*/MAX/MGA
type: Species

032222
stoichiometry: 1.0
species: 299838
type: SpeciesReference

028903
stoichiometry: 1.0
species: 299410
type: SpeciesReference

300600
product: 027871
reactant: 027859
notes: Notes by CellDesigner PMID: 11883315
fast: false
reversible: false
type: Reaction

032882
stoichiometry: 1.0
species: 299313
type: SpeciesReference

028123
stoichiometry: 1.0
species: 299313
type: SpeciesReference

301021
product: 031477
reactant: 031465
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

031525
stoichiometry: 1.0
species: 299380
type: SpeciesReference

300328
product: 025647
reactant: 025635
notes: PMID: 9819415
fast: false
reversible: false
type: Reaction

299077
notes: molecular chaperone protein.
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: HSP90
type: Species

029827
stoichiometry: 1.0
species: 299483
type: SpeciesReference

299148
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC2
type: Species

027991
stoichiometry: 1.0
species: 299432
type: SpeciesReference

300352
product: 025863
reactant: 025851
notes: PMID: 14684737
fast: false
reversible: false
type: Reaction

034226
stoichiometry: 1.0
species: 298923
type: SpeciesReference

301047
product: 031741
reactant: 031729
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

027319
stoichiometry: 1.0
species: 299380
type: SpeciesReference

034334
stoichiometry: 1.0
species: 299527
type: SpeciesReference

299990
product: 021637
reactant: 021625
reactant: 021613
notes: PMID: 12004135 PMID: 15126619 PMID: 15536069
fast: false
reversible: false
type: Reaction

299468
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: FSHR
type: Species

300815
product: 029803
reactant: 029791
notes: Notes by CellDesigner PMID: 8760872 reaction: direct PMID: 10766737PMID: 10733529
fast: false
reversible: false
type: Reaction

300288
product: 025191
reactant: 025179
notes: Cell cycle inhibition by sequestration of DP1 in the nucleolus. PMID: 16135794 PMID: 12446760
fast: false
reversible: false
type: Reaction

299736
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SSR4
type: Species

300209
modifier: 024206
product: 024194
reactant: 024182
fast: false
reversible: false
type: Reaction

300680
product: 028543
reactant: 028531
notes: PMID: 15510213
fast: false
reversible: false
type: Reaction

021037
stoichiometry: 1.0
species: 298908
type: SpeciesReference

032306
stoichiometry: 1.0
species: 299840
type: SpeciesReference

033722
stoichiometry: 1.0
species: 299840
type: SpeciesReference

301150
product: 032726
reactant: 032714
notes: PMID: 16325355
fast: false
reversible: false
type: Reaction

026424
stoichiometry: 1.0
species: 299418
type: SpeciesReference

031633
stoichiometry: 1.0
species: 298923
type: SpeciesReference

300602
product: 027895
reactant: 027883
notes: Notes by CellDesigner PMID: 14990995 reaction: direct
fast: false
reversible: false
type: Reaction

300395
product: 026247
reactant: 026235
notes: PMID: 15210709
fast: false
reversible: false
type: Reaction

299075
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin D1*
type: Species

301023
product: 031501
reactant: 031489
notes: PMID: 12665581
fast: false
reversible: false
type: Reaction

299840
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F1_alone
type: Species

300354
product: 025887
reactant: 025875
notes: PMID: 11559537 PMID: 11704823
fast: false
reversible: false
type: Reaction

300015
product: 021949
reactant: 021937
reactant: 021925
notes: (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false
type: Reaction

029251
stoichiometry: 1.0
species: 299432
type: SpeciesReference

021049
stoichiometry: 1.0
species: 298946
type: SpeciesReference

301045
product: 031717
reactant: 031705
notes: Notes by CellDesigner PMID: 16135806 reaction: direct
fast: false
reversible: false
type: Reaction

019956
stoichiometry: 1.0
species: 298881
type: SpeciesReference

024446
stoichiometry: 1.0
species: 299095
type: SpeciesReference

299038
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: MAX/MGA
type: Species

299843
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F2_alone
type: Species

299730
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SPAG7
type: Species

021685
stoichiometry: 1.0
species: 299016
type: SpeciesReference

301215
product: 033326
reactant: 033314
notes: Notes by CellDesigner PMID: 15782160 reaction: direct
fast: false
reversible: false
type: Reaction

028279
stoichiometry: 1.0
species: 299483
type: SpeciesReference

300573
product: 027631
reactant: 027619
notes: PMID: 15897325
fast: false
reversible: false
type: Reaction

030805
stoichiometry: 1.0
species: 299339
type: SpeciesReference

299104
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4
type: Species

030476
stoichiometry: 1.0
species: 298923
type: SpeciesReference

032774
stoichiometry: 1.0
species: 299717
type: SpeciesReference

298847
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: ATM
type: Species

031825
stoichiometry: 1.0
species: 298923
type: SpeciesReference

020641
stoichiometry: 1.0
species: 298926
type: SpeciesReference

032114
stoichiometry: 1.0
species: 299663
type: SpeciesReference

298965
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK4/CDKN1B
type: Species

300461
product: 026815
reactant: 026803
notes: PMID: 15044096
fast: false
reversible: false
type: Reaction

300810
product: 029755
reactant: 029743
notes: Notes by CellDesigner PMID: 14990995 reaction: indirect intermediate: MYC
fast: false
reversible: false
type: Reaction

019968
stoichiometry: 1.0
species: 298892
type: SpeciesReference

027619
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300437
product: 026623
reactant: 026611
notes: PMID: 15014447
fast: false
reversible: false
type: Reaction

020004
stoichiometry: 1.0
species: 298857
type: SpeciesReference

021613
stoichiometry: 1.0
species: 299033
type: SpeciesReference

033530
stoichiometry: 1.0
species: 299840
type: SpeciesReference

026959
stoichiometry: 1.0
species: 299406
type: SpeciesReference

300705
product: 028783
reactant: 028771
notes: Notes by CellDesigner PMID: 12566389 reaction: direct
fast: false
reversible: false
type: Reaction

028591
stoichiometry: 1.0
species: 299671
type: SpeciesReference

299818
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p21Cip*
type: Species

298923
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F4
type: Species

021805
stoichiometry: 1.0
species: 299056
type: SpeciesReference

300063
product: 022477
reactant: 022465
reactant: 022452
notes: PMID: 10385618 PMID: 10498883 (ref REACTOME) PMID: 9106657
fast: false
reversible: false
type: Reaction

031021
stoichiometry: 1.0
species: 299410
type: SpeciesReference

030055
stoichiometry: 1.0
species: 299838
type: SpeciesReference

027571
stoichiometry: 1.0
species: 299840
type: SpeciesReference

023330
stoichiometry: 1.0
species: 299173
type: SpeciesReference

024590
stoichiometry: 1.0
species: 298958
type: SpeciesReference

029203
stoichiometry: 1.0
species: 299516
type: SpeciesReference

029695
stoichiometry: 1.0
species: 299838
type: SpeciesReference

301328
product: 034408
reactant: 034396
reactant: 034384
notes: p107 binds to and inhibits cyclinA-CDK2, independantly of its phosphorylation state. PMID: 15456871 PMID: 12006580 PMID: 11237530
fast: false
reversible: false
type: Reaction

299144
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin B1*
type: Species

027883
stoichiometry: 1.0
species: 299309
type: SpeciesReference

300464
product: 026839
reactant: 026827
notes: PMID: 11883315
fast: false
reversible: false
type: Reaction

033242
stoichiometry: 1.0
species: 299840
type: SpeciesReference

029143
stoichiometry: 1.0
species: 299812
type: SpeciesReference

300012
product: 021913
reactant: 021901
reactant: 021889
notes: (ref REACTOME) PMID: 8078588 PMID: 8741839 PMID: 8001816 PMID: 8259215
fast: false
reversible: false
type: Reaction

027763
stoichiometry: 1.0
species: 299663
type: SpeciesReference

030577
stoichiometry: 1.0
species: 298923
type: SpeciesReference

299845
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: E2F6/DP1*
type: Species

300571
product: 027607
reactant: 027595
notes: PMID: 10766737
fast: false
reversible: false
type: Reaction

301217
product: 033350
reactant: 033338
notes: Notes by CellDesigner PMID: 15574595 reaction: direct
fast: false
reversible: false
type: Reaction

025263
stoichiometry: 1.0
species: 299322
type: SpeciesReference

299732
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: SRPR
type: Species

300797
product: 029635
reactant: 029623
notes: Notes by CellDesigner PMID: 14532106 reaction: direct
fast: false
reversible: false
type: Reaction

298849
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p14ARF*
type: Species

023402
stoichiometry: 1.0
species: 299180
type: SpeciesReference

300179
modifier: 023834
product: 023822
reactant: 023810
notes: Cyclin E phosphorylation by CDK2 at Thr-380. PMID: 8861947 Autophosphorylation of the complex cyclinE/CDK2 at Thr-380 and Thr-62. Phosphorylation at Thr-380 also by GSK-3B. Two other sites of regulation: Ser-372 et Ser-384 PMID: 16131838
fast: false
reversible: false
type: Reaction

025863
stoichiometry: 1.0
species: 299441
type: SpeciesReference

299106
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDK6/cyclin D1*
type: Species

031994
stoichiometry: 1.0
species: 299311
type: SpeciesReference

298926
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: DP2*
type: Species

033830
stoichiometry: 1.0
species: 299783
type: SpeciesReference

028447
stoichiometry: 1.0
species: 299681
type: SpeciesReference

299884
product: 020256
reactant: 020244
reactant: 020232
notes: E2F1 sequestrated by ARF in the nucleolus. PMID: 16135794 PMID: 12446760
fast: false
reversible: false
type: Reaction

019896
stoichiometry: 1.0
species: 298877
type: SpeciesReference

028831
stoichiometry: 1.0
species: 299416
type: SpeciesReference

024626
stoichiometry: 1.0
species: 298960
type: SpeciesReference

026385
stoichiometry: 1.0
species: 299840
type: SpeciesReference

300439
product: 026647
reactant: 026635
notes: PMID: 16107498
fast: false
reversible: false
type: Reaction

026347
stoichiometry: 1.0
species: 299420
type: SpeciesReference

022922
stoichiometry: 1.0
species: 299126
type: SpeciesReference

032414
stoichiometry: 1.0
species: 299711
type: SpeciesReference

026272
stoichiometry: 1.0
species: 299425
type: SpeciesReference

034710
stoichiometry: 1.0
species: 299581
type: SpeciesReference

299184
notes: Inactivated by CHEK1 and CHEK2 PMID: 12478465
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC25C
type: Species

029863
stoichiometry: 1.0
species: 299838
type: SpeciesReference

022525
stoichiometry: 1.0
species: 299108
type: SpeciesReference

299933
product: 020845
reactant: 020833
reactant: 020821
fast: false
reversible: false
type: Reaction

299146
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: a871_degraded
type: Species

300707
product: 028807
reactant: 028795
notes: Notes by CellDesigner PMID: 14597855 reaction: direct
fast: false
reversible: false
type: Reaction

034010
stoichiometry: 1.0
species: 298923
type: SpeciesReference

030515
stoichiometry: 1.0
species: 299507
type: SpeciesReference

299559
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: cyclin B1*
type: Species

031933
stoichiometry: 1.0
species: 299647
type: SpeciesReference

300434
product: 026599
reactant: 026587
notes: PMID: 10766737 PMID: 14576826
fast: false
reversible: false
type: Reaction

028555
stoichiometry: 1.0
species: 299843
type: SpeciesReference

299847
modifier: 019811
product: 019799
reactant: 019787
notes: PMID: 8832394
fast: false
reversible: false
type: Reaction

299293
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: ATM/NBS1
type: Species

030793
stoichiometry: 1.0
species: 298923
type: SpeciesReference

030913
stoichiometry: 1.0
species: 298923
type: SpeciesReference

298962
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin D1*/CDK6/CDKN1B
type: Species

033614
stoichiometry: 1.0
species: 299778
type: SpeciesReference

031261
stoichiometry: 1.0
species: 299391
type: SpeciesReference

026007
stoichiometry: 1.0
species: 299563
type: SpeciesReference

021577
stoichiometry: 1.0
species: 299011
type: SpeciesReference

024554
stoichiometry: 1.0
species: 299261
type: SpeciesReference

300177
product: 023798
reactant: 023786
reactant: 023774
notes: Complex cyclinA-CDK2 inhibited by its interaction with CKI PMID: 10385618
fast: false
reversible: false
type: Reaction

024290
stoichiometry: 1.0
species: 299215
type: SpeciesReference

034607
stoichiometry: 1.0
species: 299477
type: SpeciesReference

025635
stoichiometry: 1.0
species: 299298
type: SpeciesReference

030781
stoichiometry: 1.0
species: 299626
type: SpeciesReference

029587
stoichiometry: 1.0
species: 299339
type: SpeciesReference

300576
product: 027655
reactant: 027643
notes: PMID: 11313881
fast: false
reversible: false
type: Reaction

299182
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: CDC25C
type: Species

020989
stoichiometry: 1.0
species: 298951
type: SpeciesReference

299887
modifier: 020292
product: 020280
reactant: 020268
notes: p14ARF induce the degradation of E2F1, E2F2 and E2F3 via the proteasome PMID: 11274364
fast: false
reversible: false
type: Reaction

033686
stoichiometry: 1.0
species: 299778
type: SpeciesReference

299814
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: UDG1A
type: Species

029647
stoichiometry: 1.0
species: 299838
type: SpeciesReference

021505
stoichiometry: 1.0
species: 299009
type: SpeciesReference

030103
stoichiometry: 1.0
species: 298923
type: SpeciesReference

301212
product: 033302
reactant: 033290
notes: PMID: 15936277
fast: false
reversible: false
type: Reaction

032738
stoichiometry: 1.0
species: 299840
type: SpeciesReference

299295
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: p14ARF*/DP1*
type: Species

027043
stoichiometry: 1.0
species: 299840
type: SpeciesReference

030853
stoichiometry: 1.0
species: 299416
type: SpeciesReference

033134
stoichiometry: 1.0
species: 299748
type: SpeciesReference

298960
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: cyclin E1*/CDK2
type: Species

023738
stoichiometry: 1.0
species: 299224
type: SpeciesReference

029299
stoichiometry: 1.0
species: 299585
type: SpeciesReference

299556
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: CDC6
type: Species

024962
stoichiometry: 1.0
species: 299790
type: SpeciesReference

029071
stoichiometry: 1.0
species: 299380
type: SpeciesReference

299930
product: 020809
reactant: 020797
reactant: 020785
fast: false
reversible: false
type: Reaction

033290
stoichiometry: 1.0
species: 299313
type: SpeciesReference

027907
stoichiometry: 1.0
species: 299309
type: SpeciesReference

021217
stoichiometry: 1.0
species: 298956
type: SpeciesReference

032162
stoichiometry: 1.0
species: 299661
type: SpeciesReference

299101
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDK6/cyclin D1*
type: Species

027847
stoichiometry: 1.0
species: 299455
type: SpeciesReference

023030
stoichiometry: 1.0
species: 299175
type: SpeciesReference

299180
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: cyclin B1*/CDC2
type: Species

026803
stoichiometry: 1.0
species: 299840
type: SpeciesReference

022633
stoichiometry: 1.0
species: 299091
type: SpeciesReference

020052
stoichiometry: 1.0
species: 298810
type: SpeciesReference

299142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298793
name: CDC20
type: Species

299420
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: carboxylesterase*
type: Species

300174
product: 023762
reactant: 023750
reactant: 023738
notes: Complex cyclinE-CDK2 inhibited by its interaction with CKI. PMID: 10385618
fast: false
reversible: false
type: Reaction

020761
stoichiometry: 1.0
species: 298906
type: SpeciesReference

299816
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298802
name: BRD7
type: Species

298921
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 298800
name: E2F4
type: Species