304619
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304667
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305937
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product: 635333
reactant: 635321
notes: GTP+Ras+Cdc42: PMID: 9305638
fast: false
reversible: false
type: Reaction

635333
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species: 304871
type: SpeciesReference

305239
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304861
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633203
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species: 304589
type: SpeciesReference

305897
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reactant: 634889
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fast: false
reversible: false
type: Reaction

636581
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species: 305018
type: SpeciesReference

305538
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initial amount: NaN
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name: Complex(Rb/E2F)
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306400
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reactant: 641541
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fast: false
reversible: false
type: Reaction

639957
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species: 305368
type: SpeciesReference

305259
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640568
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species: 305446
type: SpeciesReference

637901
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species: 305145
type: SpeciesReference

634623
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species: 304778
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636497
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species: 305005
type: SpeciesReference

304791
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initial amount: NaN
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type: Species

640496
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species: 305486
type: SpeciesReference

305297
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639885
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species: 305067
type: SpeciesReference

306228
product: 639368
reactant: 639356
reactant: 639344
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reversible: false
type: Reaction

632974
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species: 304550
type: SpeciesReference

641469
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species: 305616
type: SpeciesReference

641553
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species: 305623
type: SpeciesReference

306208
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reactant: 638984
reactant: 638972
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fast: false
reversible: false
type: Reaction

634020
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species: 304705
type: SpeciesReference

634429
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species: 304750
type: SpeciesReference

304821
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has only substance units: false
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initial amount: NaN
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name: lyso._br_EGFR
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637829
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304803
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634985
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305342
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initial amount: NaN
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name: RGS4
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305879
modifier: 634714
product: 634701
reactant: 634688
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fast: false
reversible: false
type: Reaction

304794
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boundary condition: false
has only substance units: false
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initial amount: NaN
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type: Species

305346
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initial amount: NaN
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304842
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initial amount: NaN
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type: Species

633936
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species: 304682
type: SpeciesReference

305858
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product: 634525
reactant: 634513
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reversible: false
type: Reaction

304705
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: GTP
type: Species

639632
stoichiometry: 1.0
species: 304705
type: SpeciesReference

306287
modifier: 640141
product: 640129
reactant: 640116
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reversible: false
type: Reaction

637793
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species: 305141
type: SpeciesReference

641409
stoichiometry: 1.0
species: 305559
type: SpeciesReference

641133
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species: 305595
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637973
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species: 305132
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637649
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species: 305122
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636029
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species: 305696
type: SpeciesReference

305326
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initial amount: NaN
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type: Species

638358
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species: 305126
type: SpeciesReference

635093
stoichiometry: 1.0
species: 304839
type: SpeciesReference

305559
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: Complex(p21/Cyclin D/Cdk4/6)
type: Species

634045
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species: 304694
type: SpeciesReference

635993
stoichiometry: 1.0
species: 305692
type: SpeciesReference

636641
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species: 305021
type: SpeciesReference

638514
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species: 305215
type: SpeciesReference

306002
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modifier: 636137
product: 636125
reactant: 636113
notes: active ERK1/2: PMID: 9242373 PMID: 7673108 PMID: 7478566 PMID: 7592690 PMID: 8621459 active RSK: PMID: 9242373
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reversible: false
type: Reaction

637613
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species: 305122
type: SpeciesReference

306289
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product: 640180
product: 640167
reactant: 640154
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reversible: false
type: Reaction

304882
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: a215_degraded
type: Species

640941
stoichiometry: 1.0
species: 305577
type: SpeciesReference

306206
product: 638960
reactant: 638948
reactant: 638936
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reversible: false
type: Reaction

633275
stoichiometry: 1.0
species: 304609
type: SpeciesReference

305411
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: Chk
type: Species

306403
product: 641577
reactant: 641565
notes: PMID: 9287210
fast: false
reversible: false
type: Reaction

638069
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species: 305177
type: SpeciesReference

633828
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species: 304672
type: SpeciesReference

304640
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boundary condition: false
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initial amount: NaN
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name: PLC_gamma
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633756
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species: 304658
type: SpeciesReference

633383
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species: 304616
type: SpeciesReference

304577
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initial amount: NaN
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name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/active_br_SOS1)
type: Species

639092
stoichiometry: 1.0
species: 304694
type: SpeciesReference

640544
stoichiometry: 1.0
species: 305443
type: SpeciesReference

304518
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: EGFR
type: Species

637925
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species: 305145
type: SpeciesReference

636473
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species: 305003
type: SpeciesReference

638550
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species: 305226
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639861
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species: 305070
type: SpeciesReference

305273
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initial amount: NaN
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305534
constant: false
boundary condition: false
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initial amount: NaN
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name: Rb
type: Species

304643
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: PLC_gamma__br_@EGFR._br_Y992/1173P
type: Species

305748
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product: 633035
reactant: 633023
notes: active EGFR: PMID: 12006650 PMID: 11084343 PMID: 7518560 PMID: 7527043
fast: false
reversible: false
type: Reaction

304557
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boundary condition: false
has only substance units: false
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initial amount: NaN
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635357
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species: 304871
type: SpeciesReference

637049
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species: 305062
type: SpeciesReference

304538
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boundary condition: false
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initial amount: NaN
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name: ATP
type: Species

306005
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modifier: 636185
product: 636173
reactant: 636161
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reversible: false
type: Reaction

305433
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Shc_br_@ErbB3_br_Y1309P
type: Species

634688
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species: 304574
type: SpeciesReference

641661
stoichiometry: 1.0
species: 305640
type: SpeciesReference

306282
product: 640066
reactant: 640054
reactant: 640042
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fast: false
reversible: false
type: Reaction

305872
product: 634623
reactant: 634611
notes: PMID: 10816576
fast: false
reversible: false
type: Reaction

305391
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: Complex(active_br_c-Src/active_br_Pyk2)
type: Species

634961
stoichiometry: 1.0
species: 304815
type: SpeciesReference

304807
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boundary condition: false
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initial amount: NaN
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name: a178_degraded
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633083
stoichiometry: 1.0
species: 304574
type: SpeciesReference

641577
stoichiometry: 1.0
species: 305625
type: SpeciesReference

635717
stoichiometry: 1.0
species: 304927
type: SpeciesReference

634574
stoichiometry: 1.0
species: 304771
type: SpeciesReference

305720
notes: PMID: 10214951 PMID: 11252954
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: EGF / TGF_alpha_ / HB-EGF_br_amphiregulin / biregulin_br_betacellulin / epiregulin
type: Species

636749
stoichiometry: 1.0
species: 305033
type: SpeciesReference

633600
stoichiometry: 1.0
species: 304632
type: SpeciesReference

304884
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: MEKK4
type: Species

306429
modifier: 641865
product: 641853
reactant: 641841
notes: autophosphorylation: PMID: 10455013
fast: false
reversible: false
type: Reaction

305120
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: IP_sub_3_endsub_R
type: Species

633672
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species: 304640
type: SpeciesReference

639801
stoichiometry: 1.0
species: 305332
type: SpeciesReference

639260
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species: 305329
type: SpeciesReference

304971
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: m.c-jun
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305322
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Complex(GTP/G_alpha_ _sub_12/13)
type: Species

306203
modifier: 638924
product: 638912
product: 638899
reactant: 638887
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reversible: false
type: Reaction

641877
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species: 305690
type: SpeciesReference

638442
stoichiometry: 1.0
species: 305223
type: SpeciesReference

638394
stoichiometry: 1.0
species: 305202
type: SpeciesReference

634901
stoichiometry: 1.0
species: 304807
type: SpeciesReference

304887
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: MEKK4_br_@GTP-Rac1_br_-Cdc42
type: Species

304847
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: actin_br_reorganization
type: Species

305874
modifier: 634675
modifier: 634662
product: 634649
reactant: 634636
notes: recycling: PMID: 10816576 SHP1@EGFR.Y1173P: PMID: 9733788 SHP2@EGFR: PMID: 14560030
fast: false
reversible: false
type: Reaction

635057
stoichiometry: 1.0
species: 304833
type: SpeciesReference

306284
product: 640103
reactant: 640091
reactant: 640079
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fast: false
reversible: false
type: Reaction

634477
stoichiometry: 1.0
species: 304532
type: SpeciesReference

637361
stoichiometry: 1.0
species: 305604
type: SpeciesReference

305236
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: active_br_truncated_br_PLC_beta
type: Species

633299
stoichiometry: 1.0
species: 305500
type: SpeciesReference

305473
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: E2F
type: Species

304664
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/Pyk2)
type: Species

641949
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species: 305132
type: SpeciesReference

636353
stoichiometry: 1.0
species: 304971
type: SpeciesReference

636533
stoichiometry: 1.0
species: 305008
type: SpeciesReference

639741
stoichiometry: 1.0
species: 305308
type: SpeciesReference

305277
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Complex(G_beta/G_gamma)
type: Species

633419
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species: 304569
type: SpeciesReference

304918
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: MKK7
type: Species

305122
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: IP_sub_3_endsub_R
type: Species

305835
notes: active RN-tre: PMID: 11099046
product: 634237
modifier: 634261
reactant: 634213
modifier: 634249
type: Reaction
reversible: false
product: 634225
fast: false

639729
stoichiometry: 1.0
species: 305301
type: SpeciesReference

632842
stoichiometry: 1.0
species: 304527
type: SpeciesReference

306319
modifier: 640520
product: 640508
reactant: 640496
notes: ErbB4: PMID: 10353604
fast: false
reversible: false
type: Reaction

306152
product: 637997
reactant: 637985
reactant: 637973
notes: PMID: 14652114
fast: false
reversible: false
type: Reaction

304647
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Pyk2
type: Species

641421
stoichiometry: 1.0
species: 305620
type: SpeciesReference

305723
notes: ligand: PMID: 10880430 PMID: 11252954 PMID: 10214951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Complex(NRG-1 biregulin_br_NRG-2 / heregulin/active_br_ErbB3)
type: Species

634177
stoichiometry: 1.0
species: 304718
type: SpeciesReference

639212
stoichiometry: 1.0
species: 304713
type: SpeciesReference

640508
stoichiometry: 1.0
species: 305437
type: SpeciesReference

305804
modifier: 633768
product: 633756
reactant: 633744
notes: autophosphorylation: PMID: 14963038 PMID: 10704819
fast: false
reversible: false
type: Reaction

305145
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: cADPR
type: Species

633888
stoichiometry: 1.0
species: 305613
type: SpeciesReference

305457
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: m.cyclin D
type: Species

304935
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK2
type: Species

305164
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(CaM/cyt._br_Ca_super_2+)
type: Species

305126
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PKA
type: Species

637157
stoichiometry: 1.0
species: 305082
type: SpeciesReference

305764
modifier: 633251
product: 633239
reactant: 633227
notes: active EGFR: PMID: 14560030
fast: false
reversible: false
type: Reaction

634829
stoichiometry: 1.0
species: 304799
type: SpeciesReference

306172
modifier: 638286
modifier: 638274
product: 638262
reactant: 638250
notes: Galpha q: PMID: 12790797 PMID: 12771155 Galpha12/13: PMID: 12515866 PMID: 12771155
fast: false
reversible: false
type: Reaction

305186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/RhoA)
type: Species

306008
modifier: 636245
modifier: 636233
product: 636221
reactant: 636209
notes: active ERK1/2: PMID: 9242373 PMID: 7673108 PMID: 7478566 PMID: 7592690 PMID: 8621459 active RSK: PMID: 9242373
fast: false
reversible: false
type: Reaction

635465
stoichiometry: 1.0
species: 304895
type: SpeciesReference

305105
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PKC
type: Species

305476
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: a646_degraded
type: Species

639392
stoichiometry: 1.0
species: 305326
type: SpeciesReference

641481
stoichiometry: 1.0
species: 305632
type: SpeciesReference

304954
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Shc_br_@EGFR._br_Y1148/1173P/Grb2/SOS1)
type: Species

641325
stoichiometry: 1.0
species: 305581
type: SpeciesReference

306028
product: 636449
reactant: 636437
notes: PMID: 9069263
fast: false
reversible: false
type: Reaction

305797
product: 633660
reactant: 633648
reactant: 633636
notes: PMID: 12006650 PMID: 9544989 PMID: 7527043
fast: false
reversible: false
type: Reaction

304868
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MLK3_br_@Rac1 or Cdc42
type: Species

304687
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PAK1
type: Species

640005
stoichiometry: 1.0
species: 305373
type: SpeciesReference

641265
stoichiometry: 1.0
species: 305645
type: SpeciesReference

634008
stoichiometry: 1.0
species: 304710
type: SpeciesReference

641925
stoichiometry: 1.0
species: 305708
type: SpeciesReference

640712
stoichiometry: 1.0
species: 305455
type: SpeciesReference

638899
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species: 305239
type: SpeciesReference

305479
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Grb2
type: Species

636689
stoichiometry: 1.0
species: 305030
type: SpeciesReference

305166
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: phosphatidyl_br_choline
type: Species

305850
notes: hydrolysis: PMID: 14663478 beta2-chimaerin (RacGAP): PMID: 1903516 PMID: 8496137 PMID: 11278894
product: 634441
type: Reaction
modifier: 634465
product: 634429
reversible: false
reactant: 634417
modifier: 634453
fast: false

305147
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Complex(cADPR/FKBP)
type: Species

306174
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product: 638310
reactant: 638298
notes: active PKA: PMID: 15150446
fast: false
reversible: false
type: Reaction

637253
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species: 305094
type: SpeciesReference

636917
stoichiometry: 1.0
species: 305684
type: SpeciesReference

305705
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: PDK1
type: Species

305233
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: truncated_br_PLC_beta
type: Species

305184
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/RhoA)
type: Species

634369
stoichiometry: 1.0
species: 304745
type: SpeciesReference

633143
stoichiometry: 1.0
species: 304572
type: SpeciesReference

638984
stoichiometry: 1.0
species: 305259
type: SpeciesReference

638370
stoichiometry: 1.0
species: 305206
type: SpeciesReference

305107
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: DAG
type: Species

305726
notes: ligand: PMID: 10214951 PMID: 11252954 PMID: 10880430 sutophosphorylation: PMID: 10880430
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Complex(active_br_ErbB4/HB-EGF / NRG-1 / 2 / 3 / 4_br_betacellulin / epiregulin)
type: Species

638948
stoichiometry: 1.0
species: 305242
type: SpeciesReference

305745
modifier: 633011
modifier: 632998
product: 632986
reactant: 632974
notes: active EGFR: PMID: 12006650 PMID: 8034616 PMID: 9544989 PMID: 7518560 PMID: 7527043 KDI1: PMID: 12842895
fast: false
reversible: false
type: Reaction

637661
stoichiometry: 1.0
species: 305120
type: SpeciesReference

304995
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p53
type: Species

640772
stoichiometry: 1.0
species: 305464
type: SpeciesReference

304914
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_MKK4
type: Species

635933
stoichiometry: 2.0
species: 305678
type: SpeciesReference

304976
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Jun
type: Species

305831
reactant: 634165
reactant: 634153
notes: active Rin1@GTP+Ras: PMID: 11703925 GDP-GTP exchange: PMID: 11703925
fast: false
product: 634189
product: 634177
reversible: false
type: Reaction
modifier: 634201

634925
stoichiometry: 1.0
species: 304815
type: SpeciesReference

639284
stoichiometry: 1.0
species: 305322
type: SpeciesReference

638226
stoichiometry: 1.0
species: 304694
type: SpeciesReference

640436
stoichiometry: 1.0
species: 305429
type: SpeciesReference

635297
stoichiometry: 1.0
species: 304868
type: SpeciesReference

639825
stoichiometry: 1.0
species: 305164
type: SpeciesReference

305169
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: choline
type: Species

305793
modifier: 633624
modifier: 633612
product: 633600
reactant: 633588
notes: Gab1: PMID: 11943184 PMID: 10648629 PMID: 15550174 Gab1@EGFR.Y1068/1086P: PMID: 10648629
fast: false
reversible: false
type: Reaction

305808
modifier: 633816
modifier: 633804
product: 633792
reactant: 633780
notes: Galpha 13: PMID: 10821841 PMID: 8849729 GPCR: PMID: 10704819 PMID: 11252954 autophosphorylation: PMID: 14963038 PMID: 10704819 cyt.Ca: PMID: 10704819 PMID: 11252954
fast: false
reversible: false
type: Reaction

305452
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: cyclin D
type: Species

634381
stoichiometry: 1.0
species: 304694
type: SpeciesReference

305059
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p21
type: Species

641793
stoichiometry: 1.0
species: 305655
type: SpeciesReference

305102
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PDK2
type: Species

305740
modifier: 632962
modifier: 632950
product: 632938
reactant: 632926
notes: SHP1@EGFR.Y1173P: PMID: 9733788 SHP2@EGFR: PMID: 14560030
fast: false
reversible: false
type: Reaction

635189
stoichiometry: 1.0
species: 305599
type: SpeciesReference

304865
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MEKK1
type: Species

305828
reactant: 634093
fast: false
type: Reaction
modifier: 634129
modifier: 634141
product: 634105
notes: RasGAP@EGFR.Y992P:PMID: 14663478 PMID: 10740269 hydrolysis: PMID: 14663478
reversible: false
product: 634117

306025
product: 636425
reactant: 636413
fast: false
reversible: false
type: Reaction

635849
stoichiometry: 1.0
species: 304942
type: SpeciesReference

639933
stoichiometry: 1.0
species: 305364
type: SpeciesReference

639993
stoichiometry: 1.0
species: 305370
type: SpeciesReference

305141
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: SERCA
type: Species

641721
stoichiometry: 1.0
species: 305662
type: SpeciesReference

640029
stoichiometry: 1.0
species: 305384
type: SpeciesReference

641217
stoichiometry: 1.0
species: 305652
type: SpeciesReference

641301
stoichiometry: 1.0
species: 305652
type: SpeciesReference

635489
stoichiometry: 1.0
species: 304897
type: SpeciesReference

638262
stoichiometry: 1.0
species: 305196
type: SpeciesReference

305767
modifier: 633287
product: 633275
reactant: 633263
notes: active EGFR: PMID: 12127568 PMID: 7532293
fast: false
reversible: false
type: Reaction

306177
product: 638370
product: 638358
reactant: 638346
reactant: 638334
notes: PMID: 7803765
fast: false
reversible: false
type: Reaction

305913
product: 635069
reactant: 635057
reactant: 635045
notes: PMID: 11053437
fast: false
reversible: false
type: Reaction

306224
modifier: 639332
product: 639296
notes: GPCR: PMID: 9660746 PMID: 7834744 PMID: 11941304
reactant: 639260
reversible: false
type: Reaction
product: 639284
fast: false
modifier: 639320
product: 639308
reactant: 639272

305652
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Complex(Cyclin E/Cdk2)
type: Species

305129
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: PP1
type: Species

633588
stoichiometry: 1.0
species: 304629
type: SpeciesReference

305853
modifier: 634501
product: 634489
reactant: 634477
notes: GTP+Rab5a: PMID: 11703925 PMID: 11062256
fast: false
reversible: false
type: Reaction

633227
stoichiometry: 1.0
species: 304593
type: SpeciesReference

306261
product: 639849
reactant: 639837
reactant: 639825
notes: PMID: 14607243
fast: false
reversible: false
type: Reaction

640154
stoichiometry: 1.0
species: 305401
type: SpeciesReference

635537
stoichiometry: 1.0
species: 304908
type: SpeciesReference

304532
notes: PMID: 9667855 PMID: 9779993
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(ErbB1_br_ligand/active_br_EGFR)
type: Species

306387
product: 641373
reactant: 641361
notes: degradation: PMID: 7624798 PMID: 15082919 PMID: 9311993
fast: false
reversible: false
type: Reaction

636221
stoichiometry: 1.0
species: 304954
type: SpeciesReference

305991
modifier: 636005
product: 635993
reactant: 635981
notes: active ERK1: PMID: 12016217 PMID: 10856237 active ERK2: PMID: 12016217 PMID: 10856237
fast: false
reversible: false
type: Reaction

634345
stoichiometry: 1.0
species: 304750
type: SpeciesReference

638960
stoichiometry: 1.0
species: 305246
type: SpeciesReference

639428
stoichiometry: 1.0
species: 305297
type: SpeciesReference

633167
stoichiometry: 1.0
species: 304605
type: SpeciesReference

305301
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_s/G_beta/G_gamma)
type: Species

305030
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: a285_degraded
type: Species

305916
modifier: 635105
product: 635093
reactant: 635081
notes: GTP+Rac+Cdc42: PMID: 11950587 PMID: 10551809 PMID: 10559936 PMID: 12522133 PMID: 8107774
fast: false
reversible: false
type: Reaction

636209
stoichiometry: 1.0
species: 304635
type: SpeciesReference

636665
stoichiometry: 1.0
species: 305027
type: SpeciesReference

306264
product: 639873
reactant: 639861
fast: false
reversible: false
type: Reaction

304512
constant: true
size: NaN
spatial dimensions: 3.0
type: Compartment

305056
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Myc
type: Species

304951
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/SOS1)
type: Species

305455
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: cyclin E
type: Species

637997
stoichiometry: 1.0
species: 305164
type: SpeciesReference

635273
stoichiometry: 1.0
species: 304856
type: SpeciesReference

636953
stoichiometry: 1.0
species: 305054
type: SpeciesReference

639849
stoichiometry: 1.0
species: 305346
type: SpeciesReference

306221
reactant: 639188
notes: RGS4: PMID: 14607243 PMID: 11356902 RGS7: PMID: 14607243 PMID: 11356902 PMID: 10862767 Galpha: PMID: 7834744 PMID: 11941304 PMID: 12354102
product: 639200
modifier: 639248
product: 639212
reversible: false
modifier: 639236
fast: false
type: Reaction
modifier: 639224

304910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK4
type: Species

640832
stoichiometry: 1.0
species: 304856
type: SpeciesReference

305256
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: truncated_br_PLC_beta
type: Species

633431
stoichiometry: 1.0
species: 304616
type: SpeciesReference

635957
stoichiometry: 1.0
species: 305680
type: SpeciesReference

305181
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PLD
type: Species

635129
stoichiometry: 1.0
species: 304842
type: SpeciesReference

305702
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_PDK1
type: Species

305668
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: pl.m.Raf-1
type: Species

639344
stoichiometry: 1.0
species: 305326
type: SpeciesReference

304938
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_MKK1
type: Species

304892
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK3
type: Species

305825
type: Reaction
reversible: false
fast: false
modifier: 634069
modifier: 634057
reactant: 634008
product: 634032
reactant: 634020
product: 634045
notes: active SOS: PMID: 12006650 PMID: 8479541 PMID: 10740269 GDP-GTP exchange: PMID: 12006650 PMID: 10740269
modifier: 634081

634889
stoichiometry: 1.0
species: 305350
type: SpeciesReference

635165
stoichiometry: 1.0
species: 305599
type: SpeciesReference

306076
modifier: 636977
product: 636965
reactant: 636953
notes: nuc.ERK1: PMID: 1748630 PMID: 1651323 PMID: 8386367 nuc.ERK2: PMID: 1748630 PMID: 1651323 PMID: 8386367
fast: false
reversible: false
type: Reaction

641757
stoichiometry: 1.0
species: 305665
type: SpeciesReference

639368
stoichiometry: 1.0
species: 305329
type: SpeciesReference

305981
modifier: 635921
modifier: 635909
product: 635897
reactant: 635885
notes: active MKK1/2: PMID: 8622669 PMID: 9836645 PMID: 1318193 PMID: 8393135 PMID: 1411546
fast: false
reversible: false
type: Reaction

640580
stoichiometry: 1.0
species: 304682
type: SpeciesReference

305094
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(PI3K(p85)_br_@GTP-Ras/active_br_PI3K(p110))
type: Species

305488
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304509
name: PP2A
type: Species

639789
stoichiometry: 1.0
species: 305335
type: SpeciesReference

304690
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/PAK1)
type: Species

640856
stoichiometry: 1.0
species: 305556
type: SpeciesReference

305519
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Shc_br_@ErbB2_br_Y1196/1221/22P
type: Species

638154
stoichiometry: 1.0
species: 305186
type: SpeciesReference

306324
product: 640568
reactant: 640556
notes: PMID: 9990038
fast: false
reversible: false
type: Reaction

304767
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: Complex(ErbB1_br_ligand/early end._br_EGFR)
type: Species

635897
stoichiometry: 1.0
species: 305678
type: SpeciesReference

638803
stoichiometry: 1.0
species: 305236
type: SpeciesReference

305675
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: ERK1
type: Species

305054
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Myc
type: Species

638009
stoichiometry: 1.0
species: 305166
type: SpeciesReference

305910
modifier: 635033
product: 635021
reactant: 635009
notes: early end. EGFR: PMID: 10887178
fast: false
reversible: false
type: Reaction

637121
stoichiometry: 1.0
species: 305077
type: SpeciesReference

634273
stoichiometry: 1.0
species: 304726
type: SpeciesReference

305013
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PP2B
type: Species

306343
modifier: 640808
product: 640796
reactant: 640784
reactant: 640772
notes: binding: PMID: 8302605 PMID: 12459251 PMID: 8513492 p15: PMID: 8078588 PMID: 7624138 PMID: 7758941
fast: false
reversible: false
type: Reaction

637445
stoichiometry: 1.0
species: 305105
type: SpeciesReference

305645
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Cdk2
type: Species

305604
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PKB/Akt_br_@PI3,4,5-P_sub_3
type: Species

305625
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_STAT3
type: Species

635585
stoichiometry: 1.0
species: 304910
type: SpeciesReference

306363
product: 641073
reactant: 641061
reactant: 641049
notes: PMID: 14652114
fast: false
reversible: false
type: Reaction

305962
modifier: 635669
product: 635657
reactant: 635645
notes: MEKK1@GTP+Rac1/Cdc42: PMID: 9305750 PMID: 9312068
fast: false
reversible: false
type: Reaction

632890
stoichiometry: 1.0
species: 304545
type: SpeciesReference

634321
stoichiometry: 1.0
species: 304609
type: SpeciesReference

306267
product: 639897
reactant: 639885
fast: false
reversible: false
type: Reaction

637853
stoichiometry: 1.0
species: 305525
type: SpeciesReference

305074
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI3,4P_sub_2
type: Species

639464
stoichiometry: 1.0
species: 305289
type: SpeciesReference

634213
stoichiometry: 1.0
species: 304718
type: SpeciesReference

306041
reactant: 636569
modifier: 636593
fast: false
product: 636581
type: Reaction
modifier: 636617
notes: AP-1: PMID: 2119495 Elk-1: PMID: 9858538 CREB: PMID: 9858538 PMID: 8205620 PMID: 9770464
reversible: false
modifier: 636605

633996
stoichiometry: 1.0
species: 304690
type: SpeciesReference

641049
stoichiometry: 1.0
species: 305164
type: SpeciesReference

305033
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-Fos
type: Species

639308
stoichiometry: 1.0
species: 304694
type: SpeciesReference

639152
stoichiometry: 1.0
species: 305283
type: SpeciesReference

634525
stoichiometry: 1.0
species: 304755
type: SpeciesReference

636569
stoichiometry: 1.0
species: 305015
type: SpeciesReference

305377
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: S1_sub_2/3
type: Species

304745
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Cdc42/Rac/GTP)
type: Species

636113
stoichiometry: 1.0
species: 304783
type: SpeciesReference

305952
modifier: 635513
product: 635501
reactant: 635489
notes: MLK3@GTP+Rac/Cdc42: PMID: 9003778
fast: false
reversible: false
type: Reaction

636173
stoichiometry: 1.0
species: 304951
type: SpeciesReference

640079
stoichiometry: 1.0
species: 304672
type: SpeciesReference

306345
product: 640832
reactant: 640820
fast: false
reversible: false
type: Reaction

633467
stoichiometry: 1.0
species: 305515
type: SpeciesReference

305696
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RSK2
type: Species

306305
modifier: 640375
product: 640362
reactant: 640349
notes: active ErbB3: PMID: 8026468
fast: false
reversible: false
type: Reaction

304895
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_MKK3
type: Species

637289
stoichiometry: 1.0
species: 305601
type: SpeciesReference

304726
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Rin1
type: Species

305984
product: 635945
reactant: 635933
notes: PMID: 12706116 PMID: 11546808
fast: false
reversible: false
type: Reaction

632782
stoichiometry: 1.0
species: 304521
type: SpeciesReference

636857
stoichiometry: 1.0
species: 305003
type: SpeciesReference

306366
modifier: 641109
product: 641097
reactant: 641085
notes: Ca+CaM+CaMKII: PMID: 14652114
fast: false
reversible: false
type: Reaction

305015
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-fos
type: Species

305623
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_STAT1
type: Species

633780
stoichiometry: 1.0
species: 304647
type: SpeciesReference

640116
stoichiometry: 1.0
species: 305395
type: SpeciesReference

633840
stoichiometry: 1.0
species: 304677
type: SpeciesReference

306022
modifier: 636401
product: 636389
reactant: 636377
notes: active JNK: PMID: 7935387 PMID: 8224842 PMID: 1749429
fast: false
reversible: false
type: Reaction

306383
modifier: 641349
product: 641337
reactant: 641325
notes: Cdk2+Cyclin E: PMID: 9192873 PMID: 15082919
fast: false
reversible: false
type: Reaction

635225
stoichiometry: 1.0
species: 304853
type: SpeciesReference

639909
stoichiometry: 1.0
species: 305508
type: SpeciesReference

306158
modifier: 638094
modifier: 638081
product: 638069
reactant: 638057
notes: GTP+RhoA: PMID: 9013646 PMID: 9395408 PMID: 15150446 PMID: 12401203 active PKC: PMID: 9013646 PMID: 9395408 PMID: 15150446 PMID: 12401203
fast: false
reversible: false
type: Reaction

639765
stoichiometry: 1.0
species: 304713
type: SpeciesReference

305708
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_RSK2
type: Species

304932
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_JNK
type: Species

305370
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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306043
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305789
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635693
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306380
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641097
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306328
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reversible: false
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306117
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reversible: false
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305350
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636269
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637409
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306368
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635837
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635417
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reversible: false
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306156
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305608
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305584
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306340
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633359
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305987
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640284
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633443
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306302
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641973
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640245
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633972
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306243
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634549
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639176
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641025
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639704
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633515
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305647
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305822
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305354
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304722
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640054
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305774
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305587
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305373
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639572
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635201
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306046
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306245
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305672
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641181
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305802
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636509
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641385
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636833
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305581
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304829
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305541
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636881
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306096
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reversible: false
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306132
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reversible: false
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305969
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reversible: false
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305339
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638021
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305202
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name: cAMP
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304787
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305270
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notes: PI3 PMID: 4 PMID: 5P3: PMID: 12829245 PMID: 15276015 autophosphorylation: PMID: 10455013
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reversible: false
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304586
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305425
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639656
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639020
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305512
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641625
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637097
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species: 305074
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305561
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306436
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reversible: false
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635765
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638731
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632878
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636437
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636797
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637577
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305407
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product: 637253
reactant: 637241
notes: GTP+Ras: PMID: 14663478 PMID: 9529605 PMID: 11395417 PMID: 12006650 PMID: 10740269
fast: false
reversible: false
type: Reaction

641685
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species: 305640
type: SpeciesReference

306135
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modifier: 637721
product: 637709
reactant: 637697
notes: IP3R: PMID: 12167631 PMID: 9488697 RYR: PMID: 15709678 PMID: 12475791
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reversible: false
type: Reaction

305397
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boundary condition: false
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304672
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name: c-Src
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305481
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305932
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reactant: 635261
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reversible: false
type: Reaction

635645
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304762
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initial amount: NaN
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notes: MEKK4@GTP+Rac1+Cdc42: PMID: 15731347 MEKK1@GTP+Rac1/Cdc42: PMID: 12456688 PMID: 9582321 MLK3@GTP+Rac1/Cdc42: PMID: 9003778

637517
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species: 305110
type: SpeciesReference

639500
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species: 305293
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638647
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species: 305236
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304613
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name: RasGAP
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305358
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name: EP3
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305628
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initial amount: NaN
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name: nuc.STAT1
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633732
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634105
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species: 305132
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305601
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name: PKB/Akt_br_@PI3,4,5-P_sub_3
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639440
stoichiometry: 1.0
species: 305277
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304562
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notes: active MKK4: PMID: 12624093 PMID: 8622669 PMID: 11451947 PMID: 9312068
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reversible: false
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304825
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name: a184_degraded
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305515
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name: Gab1_br_@EGFR.
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name: pro HB-EGF
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633023
stoichiometry: 1.0
species: 304565
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640310
stoichiometry: 1.0
species: 305481
type: SpeciesReference

304783
constant: false
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name: Complex(Grb2_br_@early end.EGFR_br_Y1068/1086P/active_br_SOS1)
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305429
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modifier: 641901
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reversible: false
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635789
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type: SpeciesReference

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initial amount: NaN
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initial amount: NaN
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306348
modifier: 640869
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notes: CAK: PMID: 8139570
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reversible: false
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305097
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: PTEN
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641601
stoichiometry: 1.0
species: 305637
type: SpeciesReference

304479
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size: NaN
spatial dimensions: 3.0
type: Compartment

306071
modifier: 636905
product: 636893
reactant: 636881
notes: active p38MAPK: PMID: 11495913 PMID: 10811125 PMID: 10581258
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reversible: false
type: Reaction

639044
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species: 305280
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634792
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species: 304791
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636413
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species: 304980
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306138
modifier: 637769
product: 637757
reactant: 637745
notes: SERCA: PMID: 9202841 PMID: 7929371
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reversible: false
type: Reaction

305690
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boundary condition: false
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initial amount: NaN
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name: RSK
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636377
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species: 304976
type: SpeciesReference

305956
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notes: active MKK3: PMID: 8622669 active MKK4: PMID: 8622669 PMID: 9582321 active MKK6: PMID: 8622669
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reversible: false
modifier: 635573
reactant: 635525
modifier: 635549

305486
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: PI3K(p85)
type: Species

304583
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Abi1/E3b1
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305018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: m.c-fos
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633648
stoichiometry: 1.0
species: 304557
type: SpeciesReference

304702
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boundary condition: false
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initial amount: NaN
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type: Species

636701
stoichiometry: 1.0
species: 305021
type: SpeciesReference

306321
product: 640544
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fast: false
reversible: false
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304616
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boundary condition: false
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initial amount: NaN
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641841
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633311
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species: 305498
type: SpeciesReference

306093
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product: 637169
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reversible: false
type: Reaction

640472
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636065
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species: 305708
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633924
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species: 304532
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305692
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product: 636929
reactant: 636917
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fast: false
reversible: false
type: Reaction

305935
modifier: 635309
product: 635297
reactant: 635285
notes: GTP+Rac+Cdc42: PMID: 7493928
fast: false
reversible: false
type: Reaction

305229
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initial amount: NaN
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636389
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species: 304980
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306014
type: Reaction
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modifier: 636317
product: 636305
notes: CREB: PMID: 10471787 nuc.c-Jun: PMID: 10471787 AP-1: PMID: 10471787
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modifier: 636341
fast: false
reversible: false

637781
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641889
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species: 305699
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639008
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635261
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305249
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634779
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635981
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304850
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306238
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product: 639500
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reactant: 639464
product: 639512
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reversible: false
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notes: GPCR: PMID: 9660746 PMID: 7834744 PMID: 11941304 PMID: 12354102
type: Reaction

638502
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species: 305212
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304718
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reversible: false
type: Reaction

304503
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637697
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634032
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641805
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638057
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306218
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reactant: 639152
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reversible: false
type: Reaction

306415
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reversible: false
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304569
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305332
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305925
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305266
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639873
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305285
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boundary condition: false
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initial amount: NaN
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639945
stoichiometry: 1.0
species: 305358
type: SpeciesReference

640556
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species: 304682
type: SpeciesReference

306298
modifier: 640297
product: 640284
reactant: 640271
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reversible: false
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641565
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305226
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name: PLC_beta
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304501
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634586
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species: 304774
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632986
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species: 304557
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640091
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species: 304667
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305525
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634973
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initial amount: NaN
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306413
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reactant: 641637
fast: false
reversible: false
type: Reaction

634636
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type: SpeciesReference

305139
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305263
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639272
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633684
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reactant: 634766
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reversible: false
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305209
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306101
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product: 637289
reactant: 637277
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reversible: false
type: Reaction

305422
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641121
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species: 305590
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306418
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product: 641697
reactant: 641685
notes: SHP-2: PMID: 12270932
fast: false
reversible: false
type: Reaction

306215
type: Reaction
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product: 639092
modifier: 639104
notes: GPCR: PMID: 9660746 PMID: 7834744 PMID: 11941304 PMID: 12354102
modifier: 639128
product: 639080
modifier: 639116
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reactant: 639056
reactant: 639044
reversible: false

638430
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638382
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636089
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304988
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304609
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304905
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639548
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635069
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species: 304836
type: SpeciesReference

638033
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306019
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reactant: 636353
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reversible: false
type: Reaction

306183
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modifier: 638490
modifier: 638478
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product: 638442

634489
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637373
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306296
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product: 640245
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reversible: false
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637601
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305110
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304527
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name: Complex(ErbB1_br_ligand/active_br_EGFR)
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305847
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modifier: 634393
product: 634381
reactant: 634357
reversible: false
product: 634369
type: Reaction
notes: Vav2@EGFR.Y992/1148P: PMID: 12454019 active SOS: PMID: 12127568 GDP-GTP exchange: PMID: 12454019 PMID: 12127568
reactant: 634345
fast: false

639753
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304632
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634611
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species: 304774
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304599
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boundary condition: false
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initial amount: NaN
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type: Species

641337
stoichiometry: 1.0
species: 305584
type: SpeciesReference

633395
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species: 305515
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639080
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species: 305285
type: SpeciesReference

305223
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name: active_br_adenylyl_br_cyclase II
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304565
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640532
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304506
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size: NaN
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name: lysosome
type: Compartment

306293
product: 640219
reactant: 640206
notes: HB-EGF: PMID: 10622253 PMID: 11252954
fast: false
reversible: false
type: Reaction

639969
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species: 305364
type: SpeciesReference

635009
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species: 304829
type: SpeciesReference

633107
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species: 304577
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304545
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initial amount: NaN
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name: ADP
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product: 635465
reactant: 635453
notes: MKL3@GTP+Rac1/Cdc42: PMID: 9003778
fast: false
reversible: false
type: Reaction

305731
product: 632806
reactant: 632794
reactant: 632782
notes: PMID: 11252954 PMID: 7834741 PMID: 9708728
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reversible: false
type: Reaction

306181
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modifier: 638406
product: 638394
reactant: 638382
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reversible: false
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304833
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name: pl.m.SPRY2
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634561
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305335
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637817
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304908
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name: active_br_p38MAPK
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305206
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name: Complex(cAMP/R)
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641673
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species: 305046
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636305
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species: 304971
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305884
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product: 634740
reactant: 634727
notes: early end.EGFR: PMID: 12006650 PMID: 11084343
fast: false
reversible: false
type: Reaction

305549
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: Cdk4/6
type: Species

633095
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species: 304574
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633071
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species: 304565
type: SpeciesReference

641589
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species: 305625
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635729
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305759
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product: 633167
notes: active PI3K: PMID: 11395417 PMID: 12515821 binding: PMID: 12127568 PMID: 10499589
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reactant: 633131
reversible: false
reactant: 633155
modifier: 633179

306140
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product: 637793
reactant: 637781
notes: Ca+CaM+CaMKII: PMID: 15709678 PMID: 7929371
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reversible: false
type: Reaction

305191
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name: LARG
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305521
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initial amount: NaN
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name: phosphatidic_br_acid
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species: 305461
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305049
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boundary condition: false
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initial amount: NaN
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name: MKP
type: Species

636677
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species: 305021
type: SpeciesReference

304879
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boundary condition: false
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name: MEKK1_br_@GTP-Rac1_br_or -Cdc42
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304963
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name: CREB
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304524
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initial amount: NaN
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name: Complex(ErbB1_br_ligand/EGFR)
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modifier: 632902
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product: 632890
product: 632878
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reactant: 632866
reversible: false
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305220
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initial amount: NaN
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name: adenylyl_br_cyclase II
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initial amount: NaN
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305717
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initial amount: NaN
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name: pl.m._beta_ 2-chimaerin
type: Species

636929
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species: 305687
type: SpeciesReference

633155
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species: 304583
type: SpeciesReference

306186
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modifier: 638526
product: 638514
reactant: 638502
notes: Galpha s: PMID: 14519441 Galpha i: PMID: 14519441
fast: false
reversible: false
type: Reaction

305862
product: 634561
reactant: 634549
fast: false
reversible: false
type: Reaction

305154
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boundary condition: false
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name: NAD_super_+
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305135
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initial amount: NaN
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name: ER._br_Ca_super_2+
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640784
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species: 305549
type: SpeciesReference

305843
product: 634333
reactant: 634321
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fast: false
reversible: false
type: Reaction

634913
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638936
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species: 305132
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305067
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name: m.p15
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305466
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: cell cycle_br_progression
type: Species

638996
stoichiometry: 1.0
species: 305270
type: SpeciesReference

306105
modifier: 637349
modifier: 637337
product: 637325
reactant: 637313
notes: autophosphorylation: PMID: 12829245 active PDK2: PMID: 12829245
fast: false
reversible: false
type: Reaction

635945
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species: 305680
type: SpeciesReference

635117
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species: 304839
type: SpeciesReference

640424
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species: 305425
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639813
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species: 305339
type: SpeciesReference

636989
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species: 305059
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637313
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species: 305601
type: SpeciesReference

304677
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name: active c-Src_br_@Pyk2.Y402P
type: Species

305777
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product: 633395
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notes: active EGFR: PMID: 10648629
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reversible: false
type: Reaction

305173
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: PLD
type: Species

305907
product: 634997
reactant: 634985
notes: PMID: 11448952 PMID: 15210722
fast: false
reversible: false
type: Reaction

305446
constant: false
boundary condition: false
has only substance units: false
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initial amount: NaN
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name: tumorigenesis
type: Species

639296
stoichiometry: 1.0
species: 305277
type: SpeciesReference

304922
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: active_br_MKK7
type: Species

634165
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species: 304705
type: SpeciesReference

306271
product: 639921
reactant: 639909
fast: false
reversible: false
type: Reaction

633660
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species: 304635
type: SpeciesReference

638214
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species: 305184
type: SpeciesReference

635393
stoichiometry: 1.0
species: 304879
type: SpeciesReference

304635
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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type: Species

306307
modifier: 640412
product: 640400
reactant: 640388
notes: active ErbB3: PMID: 8026468
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reversible: false
type: Reaction

305735
product: 632842
reactant: 632830
reactant: 632818
notes: PMID: 11252954 PMID: 7834741 PMID: 9708728
fast: false
reversible: false
type: Reaction

632854
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species: 304527
type: SpeciesReference

305132
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initial amount: NaN
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product: 634285
reactant: 634273
notes: GTP+Ras: PMID: 11703925 PMID: 9144171 PMID: 8987396
fast: false
reversible: false
type: Reaction

306250
product: 639729
reactant: 639717
reactant: 639704
notes: PMID: 7834744 PMID: 11941304 PMID: 12354102
fast: false
reversible: false
type: Reaction

641061
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species: 305587
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641433
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species: 305634
type: SpeciesReference

305114
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: PI5K
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305659
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boundary condition: false
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initial amount: NaN
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name: Raf-1
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634309
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species: 304737
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637709
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633708
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species: 304569
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305464
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name: Cyclin D
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305678
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initial amount: NaN
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304521
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species: 304969
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306165
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306231
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product: 639404
product: 639392
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notes: Galpha: PMID: 7834744 PMID: 11941304
fast: false
reversible: false
type: Reaction

305755
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product: 633107
reactant: 633095
notes: active EGFR: PMID: 8479540 PMID: 12006650 PMID: 11084343
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reversible: false
type: Reaction

635453
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306211
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reactant: 639020
reactant: 639008
notes: PMID: 11875501
fast: false
reversible: false
type: Reaction

640017
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species: 305382
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636461
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species: 304995
type: SpeciesReference

638562
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species: 305229
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641277
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species: 305577
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304942
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641313
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304856
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304980
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name: c-Jun
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306162
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reversible: false
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305196
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633551
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634357
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reversible: false
type: Reaction

636653
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638887
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640748
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notes: active c-Src@Shc.Y317: PMID: 9990038 PMID: 7797556 KDI1: PMID: 12842895 PMID: 10075741
fast: false
reversible: false
type: Reaction

637457
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305443
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name: mitogenesis
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635081
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species: 304690
type: SpeciesReference

306276
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reactant: 639969
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reversible: false
type: Reaction

641913
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639837
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635285
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638166
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306109
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product: 637373
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fast: false
reversible: false
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641169
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637985
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species: 305160
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639620
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639356
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638912
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species: 305233
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635969
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species: 305684
type: SpeciesReference

305903
product: 634973
reactant: 634961
notes: PMID: 11448952 PMID: 15210722
fast: false
reversible: false
type: Reaction

305714
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name: _beta_2-chimaerin
type: Species

637169
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species: 305077
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634997
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species: 304825
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305157
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634417
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species: 304745
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name: CAK
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species: 305277
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name: nuc.RSK2
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305655
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name: pl.m.Raf-1
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639200
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634189
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638719
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632830
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636869
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type: SpeciesReference

304853
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305242
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name: calpain
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641253
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641205
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305751
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reactant: 633071
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fast: false
reversible: false
type: Reaction

305199
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639921
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636125
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species: 304948
type: SpeciesReference

305046
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name: target genes_br_transcription
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639981
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type: SpeciesReference

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305865
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product: 634586
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notes: active PKC: PMID: 10816576
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reversible: false
type: Reaction

633576
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species: 304629
type: SpeciesReference

306036
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product: 636545
reactant: 636533
notes: PP2B: PMID: 10329725
fast: false
reversible: false
type: Reaction

639380
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species: 305322
type: SpeciesReference

306273
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reactant: 639945
reactant: 639933
notes: PMID: 11875501
fast: false
reversible: false
type: Reaction

306377
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product: 641277
product: 641265
reactant: 641253
notes: Cdk2: PMID: 8769642 PMID: 8861947
fast: false
reversible: false
type: Reaction

638250
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species: 305191
type: SpeciesReference

633239
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species: 304599
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306189
notes: Gbetagamma: PMID: 8245028 PMID: 8387502 PMID: 12790797 Galpha q: PMID: 8245028 PMID: 8387502 PMID: 12790797
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modifier: 638599
modifier: 638586
modifier: 638574
type: Reaction
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modifier: 638623
fast: false
reversible: false
product: 638562

304658
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boundary condition: false
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initial amount: NaN
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name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/active_br_Pyk2)
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305117
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initial amount: NaN
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name: active_br_PI5K
type: Species

306236
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reactant: 639440
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fast: false
reversible: false
type: Reaction

305640
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initial amount: NaN
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name: nuc.STAT1
type: Species

633792
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305021
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634513
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639164
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type: SpeciesReference

633503
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type: SpeciesReference

635525
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species: 304905
type: SpeciesReference

306066
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fast: false
reversible: false
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304737
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initial amount: NaN
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name: RN-tre
type: Species

305815
modifier: 633912
modifier: 633900
product: 633888
reactant: 633876
notes: Shc@EGFR.Y1148/1173P: PMID: 14750954 PMID: 12048194
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reversible: false
type: Reaction

633479
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species: 304616
type: SpeciesReference

640796
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species: 305553
type: SpeciesReference

305684
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name: nuc.ERK1
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641961
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type: SpeciesReference

636161
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species: 304577
type: SpeciesReference

305780
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product: 633443
reactant: 633431
reactant: 633419
notes: Grb2@EGFR.Y1068/1086P: PMID: 11943184 PMID: 10648629 PMID: 10913131
fast: false
reversible: false
type: Reaction

306352
product: 640892
reactant: 640880
modifier: 640929
fast: false
product: 640904
reversible: false
modifier: 640916
notes: Cdk2+Cyclin E: PMID: 10499802 PMID: 12459251 PMID: 11960696 Cdk4+Cyclin D: PMID: 12459251 PMID: 11960696 dissociation: PMID: 12459251 PMID: 12459251 PMID: 11960696 PMID: 1828392 PMID: 7596417
type: Reaction

305940
modifier: 635381
product: 635369
reactant: 635357
notes: MEKK1@GTR+Rac1/Cdc42: PMID: 12456688 PMID: 12049732
fast: false
reversible: false
type: Reaction

637493
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species: 305082
type: SpeciesReference

305003
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initial amount: NaN
in compartment: 304479
name: m.p53
type: Species

305996
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product: 636065
reactant: 636053
notes: active PDK1: PMID: 12016217 PMID: 10480933 PMID: 10856237
fast: false
reversible: false
type: Reaction

641397
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species: 305546
type: SpeciesReference

636845
stoichiometry: 1.0
species: 305043
type: SpeciesReference

640232
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species: 305479
type: SpeciesReference

305900
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modifier: 634937
product: 634925
reactant: 634913
notes: c-Cbl@EGFR.Y1045P: PMID: 12456688 PMID: 15210722 PMID: 10531381 PMID: 11448952 PMID: 9851973 Ubc-H7: PMID: 15210722 PMID: 10531381 PMID: 11448952
fast: false
reversible: false
type: Reaction

306054
modifier: 636737
modifier: 636725
product: 636713
reactant: 636701
notes: active ERK1: PMID: 15136564 active ERK2: PMID: 15136564 active JNK: PMID: 15136564
fast: false
reversible: false
type: Reaction

637277
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species: 305611
type: SpeciesReference

305665
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: pl.m.Raf-1
type: Species

306391
product: 641409
reactant: 641397
reactant: 641385
notes: PMID: 7626805 PMID: 10439039 PMID: 12459251 PMID: 7758941
fast: false
reversible: false
type: Reaction

305040
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: nuc.c-Fos
type: Species

306371
product: 641193
reactant: 641181
reactant: 641169
notes: binding: PMID: 1388288 PMID: 11082295 PMID: 8513492
fast: false
reversible: false
type: Reaction

304758
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boundary condition: false
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initial amount: NaN
in compartment: 304490
name: a152_degraded
type: Species

305506
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: SHIP2
type: Species

306034
modifier: 636521
product: 636509
reactant: 636497
notes: nuc.ERK1: PMID: 8846788 PMID: 10329725 PMID: 12706116 PMID: 8386592 PMID: 11309409 nuc.ERK2: PMID: 8846788 PMID: 10329725 PMID: 12706116 PMID: 8386592 PMID: 11309409 JNK(UV): PMID: 8846788 PMID: 11309409
fast: false
reversible: false
type: Reaction

635213
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species: 304850
type: SpeciesReference

305611
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: PKB/Akt
type: Species

640066
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species: 305387
type: SpeciesReference

305599
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boundary condition: false
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initial amount: NaN
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name: active_br_LIMK1
type: Species

306334
product: 640700
reactant: 640688
fast: false
reversible: false
type: Reaction

305361
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: EP2/4
type: Species

305762
modifier: 633215
product: 633203
reactant: 633191
notes: active EGFR: PMID: 9733788
fast: false
reversible: false
type: Reaction

305632
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: STAT3
type: Species

641769
stoichiometry: 1.0
species: 305662
type: SpeciesReference

306330
fast: false
modifier: 640640
reactant: 640616
modifier: 640676
reversible: false
type: Reaction
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product: 640628
modifier: 640664
notes: CREB: PMID: 10066798 PMID: 12459251 nuc.STAT3: PMID: 10458605 PMID: 12459251 nuc.c-Jun: PMID: 10790372 PMID: 12459251 E2F: PMID: 9584162 PMID: 12459251

305993
modifier: 636041
product: 636029
reactant: 636017
notes: autophosphorylation: PMID: 10428774 PMID: 10856237
fast: false
reversible: false
type: Reaction

305813
modifier: 633864
modifier: 633852
product: 633840
reactant: 633828
notes: active Pyk2: PMID: 8849729 PMID: 10704819
fast: false
reversible: false
type: Reaction

305662
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: pl.m.Raf-1
type: Species

641085
stoichiometry: 1.0
species: 305595
type: SpeciesReference

306258
product: 639813
reactant: 639801
reactant: 639789
notes: PMID: 14607243 PMID: 10862767
fast: false
reversible: false
type: Reaction

635681
stoichiometry: 1.0
species: 304925
type: SpeciesReference

638142
stoichiometry: 1.0
species: 305184
type: SpeciesReference

306312
modifier: 640448
product: 640436
reactant: 640424
notes: active ErbB3: PMID: 9516479
fast: false
reversible: false
type: Reaction

640844
stoichiometry: 1.0
species: 305553
type: SpeciesReference

306278
product: 640029
reactant: 640017
reactant: 640005
notes: PMID: 11185956
fast: false
reversible: false
type: Reaction

640129
stoichiometry: 1.0
species: 305397
type: SpeciesReference

306031
modifier: 636485
product: 636473
reactant: 636461
notes: nuc.c-Jun: PMID: 10072388
fast: false
reversible: false
type: Reaction

638815
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species: 305256
type: SpeciesReference

305082
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI4,5-P_sub_2
type: Species

304755
constant: false
boundary condition: false
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initial amount: NaN
in compartment: 304490
name: ErbB1_br_ligand
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305387
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initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(S1P/active_br_S1P_sub_2/3)
type: Species

636101
stoichiometry: 1.0
species: 305711
type: SpeciesReference

305577
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Cyclin E
type: Species

634285
stoichiometry: 1.0
species: 304730
type: SpeciesReference

306063
product: 636845
reactant: 636833
reactant: 636821
notes: PMID: 15136564 PMID: 15136564 PMID: 9069263
fast: false
reversible: false
type: Reaction

637133
stoichiometry: 1.0
species: 305082
type: SpeciesReference

634225
stoichiometry: 1.0
species: 304722
type: SpeciesReference

639452
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species: 305289
type: SpeciesReference

305062
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: p15
type: Species

634333
stoichiometry: 1.0
species: 304740
type: SpeciesReference

305508
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: p53
type: Species

635801
stoichiometry: 1.0
species: 304938
type: SpeciesReference

305974
modifier: 635825
modifier: 635813
product: 635801
reactant: 635789
notes: pl.m.Raf-1: PMID: 11023813 PMID: 1322500 PMID: 1326789 PMID: 8393135 MEKK1@GTP+Rac/Cdc42: PMID: 12456688 PMID: 8385802 PMID: 7624324
fast: false
reversible: false
type: Reaction

304969
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: c-jun
type: Species

638202
stoichiometry: 1.0
species: 304705
type: SpeciesReference

305613
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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type: Species

635429
stoichiometry: 1.0
species: 304887
type: SpeciesReference

635597
stoichiometry: 1.0
species: 304914
type: SpeciesReference

305151
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: ADPR
type: Species

640219
stoichiometry: 1.0
species: 304521
type: SpeciesReference

305799
modifier: 633696
product: 633684
reactant: 633672
notes: active EGFR: PMID: 10473558 PMID: 1537335 PMID: 1689310 PMID: 1700866
fast: false
reversible: false
type: Reaction

640103
stoichiometry: 1.0
species: 305391
type: SpeciesReference

641985
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species: 305717
type: SpeciesReference

306394
modifier: 641457
modifier: 641445
product: 641433
reactant: 641421
notes: active EGFR: PMID: 8378775 PMID: 9287210 active c-Src: PMID: 10358079
fast: false
reversible: false
type: Reaction

305634
constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: STAT1
type: Species

304948
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: Complex(Grb2_br_@early end.EGFR_br_Y1068/1086P/SOS1)
type: Species

305384
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boundary condition: false
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initial amount: NaN
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type: Species

305177
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: active_br_PLD
type: Species

306357
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product: 640989
reactant: 640977
notes: PP2A: PMID: 10995457 PMID: 15276015
fast: false
reversible: false
type: Reaction

639188
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species: 305285
type: SpeciesReference

633527
stoichiometry: 1.0
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636809
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635501
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305364
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633984
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638298
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634817
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633876
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species: 304672
type: SpeciesReference

305439
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640042
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species: 305377
type: SpeciesReference

639560
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species: 305297
type: SpeciesReference

305786
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product: 633515
reactant: 633503
notes: SHP2@EGFR: PMID: 12024020 PMID: 15550174
fast: false
reversible: false
type: Reaction

305575
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boundary condition: false
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initial amount: NaN
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name: Cyclin E
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641373
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species: 305541
type: SpeciesReference

305972
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product: 635765
reactant: 635753
notes: GTP+Ras: PMID: 11023813 PMID: 14663478 PMID: 12006650 PMID: 10740269 PMID: 8503013 PMID: 12446733
fast: false
reversible: false
type: Reaction

639717
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species: 305277
type: SpeciesReference

632794
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species: 304518
type: SpeciesReference

636821
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species: 305040
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305027
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type: Species

306441
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reactant: 641949
fast: false
reversible: false
type: Reaction

639404
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type: SpeciesReference

634649
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species: 304518
type: SpeciesReference

641193
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species: 305647
type: SpeciesReference

306396
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type: Reaction
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modifier: 641529
reactant: 641469
modifier: 641493
product: 641481
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633564
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635753
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type: SpeciesReference

640592
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type: SpeciesReference

305382
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636257
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type: SpeciesReference

632818
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type: SpeciesReference

638106
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species: 305177
type: SpeciesReference

304682
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306354
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product: 640953
reactant: 640941
notes: degradation: PMID: 12459251 PMID: 8769642 PMID: 8861947 SCFFbw7: PMID: 11533444
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reversible: false
type: Reaction

306193
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reversible: false
product: 638647
modifier: 638707
fast: false
type: Reaction
modifier: 638671
modifier: 638659
notes: Gbetagamma: PMID: 8245028 PMID: 8387502 PMID: 12790797 Galpha q: PMID: 8245028 PMID: 8387502 PMID: 12790797
reactant: 638635
modifier: 638683

306316
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product: 640472
reactant: 640460
notes: ErbB4: PMID: 8617750
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reversible: false
type: Reaction

635153
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species: 305561
type: SpeciesReference

640180
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species: 305404
type: SpeciesReference

306088
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product: 637133
reactant: 637121
notes: PTEN: PMID: 12829245 PMID: 15276015 PMID: 11395417
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reversible: false
type: Reaction

635405
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species: 304882
type: SpeciesReference

305637
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name: nuc.STAT3
type: Species

306056
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modifier: 636773
product: 636761
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notes: PP2A: PMID: 15136564 PP2B: PMID: 15136564
fast: false
reversible: false
type: Reaction

640880
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species: 305538
type: SpeciesReference

305437
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: PI3K(p85)_br_@ErbB4_br_Y1056P
type: Species

637889
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species: 305154
type: SpeciesReference

639476
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species: 304705
type: SpeciesReference

306169
product: 638226
fast: false
type: Reaction
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reversible: false
product: 638214
reactant: 638202
reactant: 638190
modifier: 638238

305998
product: 636101
reactant: 636089
fast: false
reversible: false
type: Reaction

305784
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product: 633479
reactant: 633467
notes: SHP2@EGFR: PMID: 12024020 PMID: 15550174
fast: false
reversible: false
type: Reaction

640628
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species: 305457
type: SpeciesReference

640271
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species: 305411
type: SpeciesReference

640700
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species: 305464
type: SpeciesReference

305572
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boundary condition: false
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initial amount: NaN
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name: SCF_super_Fbw7
type: Species

633059
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species: 304572
type: SpeciesReference

305687
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initial amount: NaN
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name: nuc.ERK1
type: Species

306254
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product: 639765
product: 639753
reactant: 639741
notes: Galpha: PMID: 7834744 PMID: 11941304 PMID: 12354102
fast: false
reversible: false
type: Reaction

306199
type: Reaction
reversible: false
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modifier: 638875
notes: Gbetagamma: PMID: 9307019 PMID: 12790797 active PKA: PMID: 10893237 PMID: 12790797
fast: false
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product: 638815
modifier: 638863
reactant: 638803
modifier: 638851

305280
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boundary condition: false
has only substance units: false
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initial amount: NaN
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name: Complex(GDP/G_alpha_ _sub_i/G_beta/G_gamma)
type: Species

306427
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modifier: 641817
product: 641805
reactant: 641793
notes: active c-Src: PMID: 7517401 PMID: 11376654 PMID: 11023813 PMID: 12551923 PMID: 10205168 active PAK1: PMID: 11376654 PMID: 11023813 PMID: 12551923 PMID: 10205168
fast: false
reversible: false
type: Reaction

639512
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species: 304694
type: SpeciesReference

306086
modifier: 637109
product: 637097
reactant: 637085
notes: SHP2: PMID: 12829245 PMID: 15276015 PMID: 11395417
fast: false
reversible: false
type: Reaction

306127
modifier: 637637
modifier: 637625
product: 637613
reactant: 637601
notes: active PKA: PMID: 12167631 IP3: PMID: 12167631
fast: false
reversible: false
type: Reaction

633131
stoichiometry: 1.0
species: 304602
type: SpeciesReference

637565
stoichiometry: 1.0
species: 305114
type: SpeciesReference

634093
stoichiometry: 1.0
species: 304702
type: SpeciesReference

636713
stoichiometry: 1.0
species: 305033
type: SpeciesReference

634153
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species: 304722
type: SpeciesReference

634766
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species: 304787
type: SpeciesReference

633636
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species: 304574
type: SpeciesReference

304839
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boundary condition: false
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initial amount: NaN
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name: Complex(Grb2_br_@EGFR._br_Y1068/1086P/PAK1_br_@GTP-Rac_br_or Cdc42)
type: Species

305920
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product: 635129
reactant: 635117
notes: autophosphorylation: PMID: 11950587 PMID: 10551809
fast: false
reversible: false
type: Reaction

634727
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species: 304565
type: SpeciesReference

305329
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_12/13/G_beta/G_gamma)
type: Species

305894
modifier: 634877
product: 634865
reactant: 634853
notes: c-Cbl@EGFR.Y1045P: PMID: 12456688 PMID: 11448952
fast: false
reversible: false
type: Reaction

638334
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species: 305209
type: SpeciesReference

304710
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Complex(GDP/Ras)
type: Species

641697
stoichiometry: 1.0
species: 305628
type: SpeciesReference

306147
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product: 637901
reactant: 637889
notes: CD38: PMID: 12475791
fast: false
reversible: false
type: Reaction

641013
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species: 305604
type: SpeciesReference

637205
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species: 305085
type: SpeciesReference

305947
modifier: 635441
product: 635429
reactant: 635417
notes: GTP+Rac+Cdc42: PMID: 9305638
fast: false
reversible: false
type: Reaction

304774
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boundary condition: false
has only substance units: false
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initial amount: NaN
in compartment: 304490
name: early end._br_EGFR
type: Species

636761
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species: 305021
type: SpeciesReference

637505
stoichiometry: 1.0
species: 305107
type: SpeciesReference

304605
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boundary condition: false
has only substance units: false
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initial amount: NaN
in compartment: 304479
name: Complex(Abi1/E3b1/Eps8/active_br_SOS1)
type: Species

635657
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species: 304922
type: SpeciesReference

304750
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boundary condition: false
has only substance units: false
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initial amount: NaN
in compartment: 304479
name: Complex(GDP/Rac/Cdc42)
type: Species

305590
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(CaM/cyt._br_Ca_super_2+/CaMK)
type: Species

304730
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: active_br_Rin1@GTP-Ras
type: Species

305494
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: RasGAP_br_@EGFR.
type: Species

304589
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
type: Species

633347
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species: 304613
type: SpeciesReference

638635
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species: 305233
type: SpeciesReference

637937
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species: 305151
type: SpeciesReference

304771
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: early end._br_EGFR
type: Species

306409
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reactant: 641613
notes: PMID: 9287210
fast: false
reversible: false
type: Reaction

634701
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species: 304783
type: SpeciesReference

637001
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species: 305070
type: SpeciesReference

306144
fast: false
product: 637853
notes: active PKA: PMID: 12790797 PMID: 9488697 PMID: 11694504 PMID: 15709678 Ca+CaM+CaMKII: PMID: 12790797 PMID: 15709678 FKBP: 15709678 cADPR: PMID: 12475791 PMID: 9013543
reversible: false
reactant: 637829
type: Reaction
modifier: 637877
product: 637841
reactant: 637817
modifier: 637865

304602
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Eps8
type: Species

633035
stoichiometry: 1.0
species: 304569
type: SpeciesReference

305413
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Chk_br_@ErbB2_br_Y1248P
type: Species

304574
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Grb2/SOS1)
type: Species

639668
stoichiometry: 1.0
species: 304694
type: SpeciesReference

304622
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PI3K(p85)
type: Species

306359
modifier: 641037
product: 641025
reactant: 641013
notes: PP2A: PMID: 10995457 PMID: 15276015
fast: false
reversible: false
type: Reaction

634740
stoichiometry: 1.0
species: 304787
type: SpeciesReference

305008
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Elk-1
type: Species

305491
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: MKK1
type: Species

304509
constant: true
size: NaN
spatial dimensions: 3.0
name: ER
type: Compartment

640977
stoichiometry: 1.0
species: 305608
type: SpeciesReference

633720
stoichiometry: 1.0
species: 304647
type: SpeciesReference

640904
stoichiometry: 1.0
species: 305473
type: SpeciesReference

640388
stoichiometry: 1.0
species: 305481
type: SpeciesReference

304799
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304490
name: Complex(Grb2_br_@early end.EGFR_br_Y1068/1086P/c-Cbl_br_@EGFR.Y1045P)
type: Species

634853
stoichiometry: 1.0
species: 304803
type: SpeciesReference

306424
modifier: 641781
product: 641769
reactant: 641757
notes: unidentified S/T kinase(s): PMID: 12551923
fast: false
reversible: false
type: Reaction

305530
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: PP1
type: Species

306083
modifier: 637073
product: 637061
reactant: 637049
notes: active c-Myc: PMID: 10454538 PMID: 12565816
fast: false
reversible: false
type: Reaction

637085
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species: 305077
type: SpeciesReference

306196
product: 638731
modifier: 638755
modifier: 638791
type: Reaction
reactant: 638719
notes: Gbetagamma: PMID: 9307019 PMID: 12790797 active PKA: PMID: 10893237 PMID: 12790797
modifier: 638767
modifier: 638743
fast: false
modifier: 638779
reversible: false

640688
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species: 305457
type: SpeciesReference

635045
stoichiometry: 1.0
species: 304794
type: SpeciesReference

305500
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Vav2
type: Species

639032
stoichiometry: 1.0
species: 305273
type: SpeciesReference

305308
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GTP/G_alpha_ _sub_s)
type: Species

641637
stoichiometry: 1.0
species: 305637
type: SpeciesReference

304572
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: SOS1
type: Species

304836
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(c-Cbl/pl.m.SPRY2)
type: Species

632866
stoichiometry: 1.0
species: 304538
type: SpeciesReference

632926
stoichiometry: 1.0
species: 304532
type: SpeciesReference

636449
stoichiometry: 1.0
species: 304988
type: SpeciesReference

305368
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(PGE_sub_2/active_br_EP3)
type: Species

305215
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_adenylyl_br_cyclase
type: Species

306444
modifier: 642009
modifier: 641997
product: 641985
reactant: 641973
notes: DAG: PMID: 12877655 PMID: 12727851 phosphatidic acid: PMID: 128777655 PMID: 12727851
fast: false
reversible: false
type: Reaction

633191
stoichiometry: 1.0
species: 304586
type: SpeciesReference

305498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Vav2_br_@EGFR.
type: Species

305944
product: 635405
reactant: 635393
notes: PMID: 12456688 PMID: 12049732
fast: false
reversible: false
type: Reaction

306010
modifier: 636281
product: 636269
reactant: 636257
notes: phosphorylation: PMID: 8205620 nuc.RSK: PMID: 9528766 PMID: 9770464
fast: false
reversible: false
type: Reaction

304815
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304503
name: late end._br_EGFR
type: Species

638310
stoichiometry: 1.0
species: 305199
type: SpeciesReference

305305
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_s)
type: Species

640362
stoichiometry: 1.0
species: 305422
type: SpeciesReference

306407
product: 641601
reactant: 641589
notes: PMID: 9287210
fast: false
reversible: false
type: Reaction

305212
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: adenylyl_br_cyclase
type: Species

636629
stoichiometry: 1.0
species: 305018
type: SpeciesReference

641541
stoichiometry: 1.0
species: 305634
type: SpeciesReference

638190
stoichiometry: 1.0
species: 305186
type: SpeciesReference

305595
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(CaM/cyt._br_Ca_super_2+/CaMK)
type: Species

636053
stoichiometry: 1.0
species: 305696
type: SpeciesReference

305890
modifier: 634841
product: 634829
reactant: 634817
notes: active c-Src: PMID: 12456688 PMID: 15210722 PMID: 11448952 PMID: 11994282
fast: false
reversible: false
type: Reaction

640460
stoichiometry: 1.0
species: 305481
type: SpeciesReference

304778
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304501
name: recyc.end._br_EGFR
type: Species

305283
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(GDP/G_alpha_ _sub_i)
type: Species

641853
stoichiometry: 1.0
species: 305702
type: SpeciesReference

304629
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(PI3K(p110)/PI3K(p85))
type: Species

306123
modifier: 637589
product: 637577
reactant: 637565
notes: phosphatidic acid: PMID: 1313792 PMID: 12790797
fast: false
reversible: false
type: Reaction

305680
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: active_br_ERK1
type: Species

305418
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304512
name: Grb2_br_@ErbB2_br_Y1139P
type: Species

305556
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Cyclin D/Cdk4/6)
type: Species

306050
product: 636689
reactant: 636677
notes: PMID: 15136564
fast: false
reversible: false
type: Reaction

640323
stoichiometry: 1.0
species: 305519
type: SpeciesReference

305923
modifier: 635177
product: 635165
reactant: 635153
notes: PAK1@GTP+Rac/Cdc42: PMID: 11950587 PMID: 10559936
fast: false
reversible: false
type: Reaction

304550
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Shc
type: Species

304713
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Pi
type: Species

637841
stoichiometry: 1.0
species: 305147
type: SpeciesReference

305977
modifier: 635873
modifier: 635861
product: 635849
reactant: 635837
notes: pl.m.Raf-1: PMID: 11023813 PMID: 1322500 PMID: 1326789 PMID: 8393135 MEKK1@GTP+Rac1/Cdc42: PMID: 8385802 PMID: 7624324
fast: false
reversible: false
type: Reaction

639644
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species: 305277
type: SpeciesReference

306080
fast: false
modifier: 637037
reversible: false
reactant: 636989
type: Reaction
product: 637001
modifier: 637013
modifier: 637025
notes: active c-Myc: PMID: 10920185 PMID: 12565816 active p53: PMID: 8242752 PMID: 11495913 nuc.STAT3: PMID: 14750954

634117
stoichiometry: 1.0
species: 304713
type: SpeciesReference

633744
stoichiometry: 1.0
species: 304664
type: SpeciesReference

305616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: STAT3
type: Species

MODEL2463576061
species: 304740
species: 305046
species: 304694
reaction: 306394
species: 305587
species: 304562
species: 305678
species: 304572
species: 305546
species: 304521
reaction: 306267
reaction: 306169
species: 305015
species: 304918
species: 304815
reaction: 306348
reaction: 305987
species: 305595
species: 305647
species: 305708
species: 304900
species: 305680
species: 305515
species: 304667
species: 305270
reaction: 305793
reaction: 305802
reaction: 305949
species: 305645
species: 305326
species: 305223
reaction: 306276
species: 305411
reaction: 306420
volume units: volume
species: 305239
species: 305040
reaction: 306144
species: 305723
species: 305085
species: 305107
species: 305581
species: 305056
reaction: 306231
species: 304976
reaction: 306236
reaction: 306138
reaction: 305928
species: 305054
species: 305169
reaction: 306140
species: 305370
species: 304616
species: 304599
reaction: 306391
reaction: 306221
reaction: 306123
reaction: 306293
species: 304861
species: 305452
species: 305132
species: 305401
reaction: 305977
species: 305177
reaction: 305822
species: 305384
species: 304908
species: 304527
species: 305637
reaction: 306096
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species: 304602
reaction: 306432
species: 304925
species: 304589
species: 305335
species: 304593
reaction: 305748
reaction: 305784
species: 305229

634441
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species: 304713
type: SpeciesReference

637757
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species: 305135
type: SpeciesReference

305553
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 304479
name: Complex(Cdk4/6/Cyclin D)
type: Species

306149
modifier: 637961
modifier: 637949
product: 637937
reactant: 637925
notes: CD38: PMID: 12475791 ATP: PMID: 12475791
fast: false
reversible: false
type: Reaction

636893
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species: 305512
type: SpeciesReference

304626
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: PI3K(p110)
type: Species

306120
modifier: 637529
reversible: false
type: Reaction
product: 637517
notes: active PLCbeta: PMID: 12790797 active truncated PLCbeta: PMID: 12790797 PLCgamma: PMID: 10579907
reactant: 637493
fast: false
product: 637505
modifier: 637541
modifier: 637553

306420
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product: 641733
reactant: 641721
notes: active PKB/Akt: PMID: 11023813 PMID: 14663478 PMID: 10576742 PMID: 11443134
fast: false
reversible: false
type: Reaction

306060
product: 636809
reactant: 636797
fast: false
reversible: false
type: Reaction

305085
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boundary condition: false
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initial amount: NaN
in compartment: 304479
name: PI4-P
type: Species

306336
modifier: 640736
product: 640724
reactant: 640712
notes: E2F: PMID: 8668155 PMID: 12760379 PMID: 11960696
fast: false
reversible: false
type: Reaction

635885
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species: 305675
type: SpeciesReference

640349
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633263
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635021
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636425
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species: 304984
type: SpeciesReference

641613
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species: 305623
type: SpeciesReference

305005
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Elk-1
type: Species

637061
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species: 305067
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639056
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species: 304705
type: SpeciesReference