http://identifiers.org/biomodels.db/MODEL1310160000#eb480d76-70d8-43a2-aad2-12abb2110075
stoichiometry: 1.0
species: COPASI49
type: SpeciesReference

COPASI27
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_Trypta
type: Species

COPASI133
type: Reaction
reversible: false
is described by: http://identifiers.org/pubmed/18620547
is: R01956
modifier: MODEL1310160000#
name: KAT2_L-Kyn
fast: false
is: http://identifiers.org/ec-code/2.6.1.7
is encoded by: http://identifiers.org/ncbigene/51166

COPASI8
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_AHCys
type: Species

COPASI123
notes: Km and kcat values taken from 17402747
is: http://identifiers.org/ec-code/2.7.7.1
name: NMNAT1
modifier: MODEL1310160000#
reversible: false
is encoded by: http://identifiers.org/ncbigene/64802
type: Reaction
is: R03005
fast: false
is described by: http://identifiers.org/pubmed/17402747

http://identifiers.org/biomodels.db/MODEL1310160000#_9bbbb097-0532-47f5-a02a-66cfedfd795b
value: 0.0065
name: Km
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#b4523f2d-766e-4c6f-a524-2501fca8ff58
value: 0.0074
name: Ka
type: LocalParameter

COPASI13
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_Acms
type: Species

COPASI88
constant: true
value: 0.0573
name: Transporter_Km_Trp_Slc7a8
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_914d8c3f-c8bc-421d-9a1d-32acf277b2c1
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_3cbea0cc-e849-42c4-a355-3f2f3e8d3d5f
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_5a48d811-cd64-47d0-adc6-4281e594b906
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#e808bb3a-7492-4a5b-91cd-b8de0ea562bf
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_4cc075f2-03cf-44de-9e9b-1b7c7d7bd177
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#c4da272c-a6c0-44c0-bcec-a21b6864a1c4
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_3d5c7115-871b-4e7d-a444-43b27a421f21
stoichiometry: 1.0
species: COPASI23
type: SpeciesReference

COPASI28
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.999999951844375
initial amount: NaN
name: M_AMP
type: Species

COPASI98
constant: true
value: 1.3
name: Transporter_kcat_Trp
type: Parameter

COPASI134
type: Reaction
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/18620547
is: R01956
is encoded by: http://identifiers.org/ncbigene/56267
fast: false
name: KAT3_L-Kyn
is: http://identifiers.org/ec-code/2.6.1.7
reversible: false

http://identifiers.org/biomodels.db/MODEL1310160000#_0d2acd00-aaee-435b-b15e-e567ab2e3751
value: 3.5
name: kcat_B
type: LocalParameter

COPASI124
fast: false
is described by: http://identifiers.org/pubmed/17288562
type: Reaction
modifier: MODEL1310160000#
is: R04323
reversible: false
is encoded by: http://identifiers.org/ncbigene/130013
is: http://identifiers.org/ec-code/4.1.1.45
name: ACMSD

COPASI9
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.9999999518
initial amount: NaN
name: M_Ketoglutarate
type: Species

COPASI14
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_Dhbpt
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_66c4d87d-89b3-4a47-b3e6-729995582a02
stoichiometry: 1.0
species: COPASI17
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_6f2ec5ed-a0db-4fbb-83d1-08a4ed9bd9b4
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

COPASI87
constant: true
value: 0.032
name: Transporter_Km_L-kyn
type: Parameter

COPASI97
is described by: http://identifiers.org/pubmed/18620547
constant: true
value: 9.76
name: KAT_kcat_L-kyn
type: Parameter

COPASI29
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.999999951844375
initial amount: NaN
name: M_ATP
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_5cb646da-5572-497a-96f5-07c1c4ae2a42
stoichiometry: 1.0
species: COPASI11
type: SpeciesReference

COPASI135
name: MAOB_Serotonin
is: R02908
reversible: false
is: http://identifiers.org/ec-code/1.4.3.4
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/15848762
is encoded by: http://identifiers.org/ncbigene/4129
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310160000#_07bd16ee-d60f-4aaa-9c14-2060806f0f4b
stoichiometry: 1.0
species: COPASI35
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#e5c3b5b7-5f60-4597-94f9-6a619ab17b95
stoichiometry: 1.0
species: COPASI5
type: SpeciesReference

COPASI25
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_Trp
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_26d6eb98-e687-47bf-b020-7eb90b228670
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_0145d5ee-0bbb-454f-b4d8-ae90046d475f
stoichiometry: 1.0
species: COPASI27
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_9522c455-4b36-48c1-a0f3-41fce296f29a
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

COPASI15
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_Formate
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_919fcd15-d21c-4f0d-b13d-0aef9b5a928b
value: 503.141
name: E_T
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_51bc3764-8696-4493-916c-6a73fa1b9f07
value: 0.18
name: kcat
type: LocalParameter

COPASI6
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_FKyn
type: Species

COPASI121
name: KYNU_FKyn
modifier: MODEL1310160000#
reversible: false
is: R03936
is: http://identifiers.org/ec-code/3.7.1.3
is encoded by: http://identifiers.org/ncbigene/8942
is described by: http://identifiers.org/pubmed/118164
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310160000#dbdf6ac3-7651-467e-8f30-e6e3b2ca4237
value: 0.176
name: kcat_A
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_66b503b1-19b9-4b34-be19-9d697d443d17
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_5bdcbb81-972a-4da7-b815-4b49a712dc32
stoichiometry: 1.0
species: COPASI55
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#c611548a-7155-4f1e-a3e2-25731b9f8637
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

COPASI86
constant: true
value: 0.495
name: KYNU_Km_L-kyn
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_332c8639-5f41-43ef-8c35-392283e4baae
stoichiometry: 1.0
species: COPASI48
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_4d325621-d552-4bdb-a19b-213bec12cc92
value: 25.9
name: kcat_B
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_9c2d470f-e113-4533-a753-d57188a679a4
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_52407f9e-2e7a-4496-96ba-6469a9880f64
stoichiometry: 1.0
species: COPASI17
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#c0ec4629-6b48-4b08-8398-7bf5ae5f47b8
value: 943912.0
name: E_T
type: LocalParameter

COPASI26
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_Trp_tRNA
type: Species

COPASI7
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_L-Kyn
type: Species

COPASI16
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_LGlu
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#c3d021fa-ab87-4f60-8db1-6553986a7796
value: 0.153
name: Kc
type: LocalParameter

COPASI136
fast: false
is encoded by: http://identifiers.org/ncbigene/4129
name: MAOB_Trypta
is: http://identifiers.org/ec-code/1.4.3.4
reversible: false
is described by: http://identifiers.org/pubmed/11754741
is: R02173
modifier: MODEL1310160000#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310160000#_5828e74f-8ccf-4f1c-83e0-4ec54fc7fd99
stoichiometry: 1.0
species: COPASI51
type: SpeciesReference

COPASI122
fast: false
name: AFMID_FAA
is: http://identifiers.org/ec-code/3.5.1.9
modifier: MODEL1310160000#
reversible: false
is: R00988
type: Reaction
is encoded by: http://identifiers.org/ncbigene/125061
is described by: http://identifiers.org/pubmed/4190298

COPASI17
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_3HKyn
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#d95e5704-acfa-4236-903f-70dbbf919c24
stoichiometry: 1.0
species: COPASI20
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#c3fd298d-4468-4360-919d-38ccdbb7ecdb
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_6bbfbdcc-3ec9-48a7-9037-0e618b2a6068
stoichiometry: 1.0
species: COPASI46
type: SpeciesReference

COPASI99
constant: true
value: 1.3
name: Transporter_kcat_L-kyn
type: Parameter

COPASI85
constant: true
value: 2.2
name: KYNU_Km_FKyn
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#f5176803-7f5d-4497-be1d-c1aa0ad8d39a
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#f5f9cdbb-5c94-4b3d-8d3d-157700b4eff3
stoichiometry: 1.0
species: COPASI54
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b7d7e86a-163c-4a58-adeb-bbdff2ebd256
stoichiometry: 1.0
species: COPASI2
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_65735ab8-2068-4d96-8bfc-d480e966c9cb
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#ab3a28cc-7871-47c6-97d8-aaaa878d437d
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#da863c77-538f-4915-90c4-0a65979ab410
value: 0.0403
name: Ka
type: LocalParameter

COPASI141
type: Reaction
is described by: http://identifiers.org/pubmed/2872885
is: Q9UHI5
reversible: true
is encoded by: http://identifiers.org/ncbigene/23428
modifier: MODEL1310160000#
name: Lkynr_Transporter_Slc7a8
fast: false
is described by: http://identifiers.org/pubmed/2723766

http://identifiers.org/biomodels.db/MODEL1310160000#d9f56182-93a4-4945-8396-05b75acc913b
stoichiometry: 1.0
species: COPASI56
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_4e236f0a-96d5-4498-bb0a-8dd0de905e73
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b0844129-f187-4d55-bcd6-f4ea704c3880
value: 9766.18
name: E_T
type: LocalParameter

COPASI84
constant: true
value: 56601.7578125
name: KYNU_E_T
type: Parameter

COPASI18
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_IndolAc
type: Species

COPASI94
constant: true
value: 0.033
name: MAO_Km_Trypta
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_76e1af9f-0b0e-4a4d-a604-876ea1b23cad
stoichiometry: 1.0
species: COPASI19
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_25c7a1c7-1246-43b7-878a-112fea0aeb68
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

COPASI120
is encoded by: http://identifiers.org/ncbigene/23475
is: http://identifiers.org/ec-code/2.4.2.19
type: Reaction
is: R03348
name: QPRT
fast: false
is described by: http://identifiers.org/pubmed/17868694
modifier: MODEL1310160000#
reversible: false

COPASI130
is: http://identifiers.org/ec-code/2.1.1.49
fast: false
type: Reaction
reversible: false
modifier: MODEL1310160000#
is: R02910
is encoded by: http://identifiers.org/ncbigene/11185
is described by: http://identifiers.org/pubmed/9852119
name: INMT_Serotonin

http://identifiers.org/biomodels.db/MODEL1310160000#b2d09f9a-fb1b-4d6f-bde4-d9009b40638f
value: 42.9
name: kcat
type: LocalParameter

COPASI83
constant: true
value: 2226.3728027344
name: Transporter_E_T_Slc7a8
type: Parameter

COPASI110
is: http://identifiers.org/ec-code/3.7.1.3
is encoded by: http://identifiers.org/ncbigene/8942
is described by: http://identifiers.org/pubmed/19143568
name: KYNU_3HKyn
reversible: false
type: Reaction
modifier: MODEL1310160000#
is: R02668
fast: false

COPASI93
constant: true
value: 0.43
name: MAO_Km_Serotonin
type: Parameter

COPASI100
is encoded by: http://identifiers.org/ncbigene/259307
modifier: MODEL1310160000#
reversible: false
is: R00677
fast: false
is: http://identifiers.org/ec-code/1.4.3.2
name: IL4I1
is described by: http://identifiers.org/pubmed/15383589
type: Reaction

COPASI19
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_IndolP
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_411d7c47-4b21-460e-93e4-db672ebd2f66
value: 1.2
name: Kb
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_129d7c21-e6e2-4e4e-b0c1-77aff6e523cd
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_6d5accce-baa8-43dd-a35b-2a1014892848
stoichiometry: 1.0
species: COPASI29
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#ee94825e-5d45-40ec-8007-c25ef982684e
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_398be542-2352-4b4d-867e-cc67bb21dd26
stoichiometry: 4.0
species: COPASI37
type: SpeciesReference

COPASI131
is described by: http://identifiers.org/pubmed/18620547
name: KAT2_3HKyn
fast: false
reversible: false
is encoded by: http://identifiers.org/ncbigene/51166
is: R04171
modifier: MODEL1310160000#
type: Reaction
is: http://identifiers.org/ec-code/2.6.1.7

http://identifiers.org/biomodels.db/MODEL1310160000#_19e75a42-f631-44cb-bb91-3458fe22be96
stoichiometry: 1.0
species: COPASI44
type: SpeciesReference

COPASI111
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/18547057
is: http://identifiers.org/ec-code/4.1.1.28
fast: false
type: Reaction
name: DDC_5HTrp
is: R02701
reversible: false
is encoded by: http://identifiers.org/ncbigene/1644

http://identifiers.org/biomodels.db/MODEL1310160000#df696327-b47c-4898-91ba-11ea1abfc844
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

COPASI82
constant: true
value: 0.028
name: KYNU_Km_3HKyn
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_73413e5c-ee89-4440-b31c-57dcf4de9f16
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b5110b01-3e4f-43d8-a01f-b972a1d04895
constant: true
size: 1.0
spatial dimensions: 3.0
name: Cytosol
type: Compartment

COPASI96
is described by: http://identifiers.org/pubmed/18620547
constant: true
value: 1.7
name: KAT_kcat_3HKyn
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#a381db90-8fd3-491c-a41a-2434b7975df4
value: 0.222
name: Ka
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_421a52d4-ea85-4852-9f5f-098d9dff9ff9
stoichiometry: 1.0
species: COPASI12
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#f4320f47-67ab-418e-9f8d-8d4b1cf03124
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_018e7818-fa96-492c-975d-6ab22be78dd8
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

COPASI132
reversible: false
type: Reaction
is encoded by: http://identifiers.org/ncbigene/56267
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/18620547
name: KAT3_3HKyn
is: R04171
fast: false
is: http://identifiers.org/ec-code/2.6.1.7

COPASI112
name: IDO_5HTrp
is encoded by: http://identifiers.org/ncbigene/3620
type: Reaction
reversible: false
is described by: http://identifiers.org/pubmed/26687
fast: false
is described by: http://identifiers.org/pubmed/19737010
is: http://identifiers.org/ec-code/1.13.11.52
modifier: MODEL1310160000#
is: R02702

http://identifiers.org/biomodels.db/MODEL1310160000#_7ebe9081-1eec-4596-b19b-75543eb89423
value: 48858.2
name: E_T
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#fa677fd3-0170-4417-a34f-a0055f52ed34
stoichiometry: 2.0
species: COPASI31
type: SpeciesReference

COPASI81
constant: true
value: 0.086
name: IMNT_Km_MTrypta
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_5ac8bc80-e34a-4ef3-82d9-35bff71ebbaa
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

COPASI95
constant: true
value: 0.042
name: IDO_Km_O2
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_374335eb-8f5b-444b-9b25-5a9c10157d3f
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

COPASI113
is described by: http://identifiers.org/pubmed/11676605
fast: false
reversible: false
type: Reaction
is: R03664
is encoded by: http://identifiers.org/ncbigene/7453
name: WARS
is: http://identifiers.org/ec-code/6.1.1.2
modifier: MODEL1310160000#

COPASI103
type: Reaction
is encoded by: http://identifiers.org/ncbigene/8942
is: R00987
is: http://identifiers.org/ec-code/3.7.1.3
is described by: http://identifiers.org/pubmed/17300176
name: KYNU_L-Kyn
is described by: http://identifiers.org/pubmed/457635
modifier: MODEL1310160000#
fast: false
reversible: false
is described by: http://identifiers.org/pubmed/19143568

http://identifiers.org/biomodels.db/MODEL1310160000#_65b7dddc-482f-417d-9241-63d44b35786a
value: 235.128
name: E_T
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#c89eba70-8e75-4875-8a0d-cfab7f90c219
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

COPASI114
fast: false
modifier: MODEL1310160000#
type: Reaction
is encoded by: http://identifiers.org/ncbigene/125061
name: AFMID_5HFKyn
reversible: false
is described by: http://identifiers.org/pubmed/4135014
is: http://identifiers.org/ec-code/3.5.1.9
is: R04911

http://identifiers.org/biomodels.db/MODEL1310160000#e2961751-4d0f-452b-b742-8bd0defaa58a
value: 0.38
name: kcat_B
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_496eb4bd-0dee-44c8-9533-e6dedc85884e
value: 18.6
name: kcat_B
type: LocalParameter

COPASI104
fast: false
is: http://identifiers.org/ec-code/1.14.16.4
is described by: http://identifiers.org/pubmed/15663479
reversible: false
is: R01814
name: TPH1
is encoded by: http://identifiers.org/ncbigene/7166
is described by: http://identifiers.org/pubmed/19816759
type: Reaction
modifier: MODEL1310160000#

http://identifiers.org/biomodels.db/MODEL1310160000#_6ff52a0f-dfeb-43f1-b313-07f70643ec47
stoichiometry: 1.0
species: COPASI27
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_71fc41a4-5506-4d90-89fc-3080eccf78f6
stoichiometry: 1.0
species: COPASI27
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b58349f4-2a7f-4e4c-ac74-bf8c1b0eaca5
value: 6.5
name: Ka
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#ae1b4ddf-9d59-4aae-ac47-5e903b9119de
value: 0.273
name: Kb
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_44212090-1574-493a-ab21-b85d38848cac
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#f1df580b-ef98-4f01-aae7-ea0209040a19
stoichiometry: 1.0
species: COPASI34
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#d547bc52-890e-466b-abce-d108f75eeb53
stoichiometry: 1.0
species: COPASI26
type: SpeciesReference

COPASI101
is encoded by: http://identifiers.org/ncbigene/6999
fast: false
type: Reaction
name: TDO
reversible: false
is: R00678
is: http://identifiers.org/ec-code/1.13.11.11
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/18370401

COPASI115
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/15656614
fast: false
reversible: false
name: Quinolic Acid formation (spontaneous)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310160000#_7563f1e8-5ba8-4e7f-9639-eba66d97b320
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_67e93b54-39e1-4888-8f16-d33c7ce9c064
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#ce825e27-d818-484d-b690-5614b89f160a
stoichiometry: 1.0
species: COPASI14
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_6c8c6bfb-6c20-46c8-b2fb-651dcbb015c8
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_54678a51-5d3c-4d47-ba98-4f9cd7cc7e57
stoichiometry: 1.0
species: COPASI42
type: SpeciesReference

COPASI129
name: INMT_MTrypta
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/9852119
fast: false
type: Reaction
is encoded by: http://identifiers.org/ncbigene/11185
reversible: false
is: http://identifiers.org/ec-code/2.1.1.49

http://identifiers.org/biomodels.db/MODEL1310160000#c24a2695-8e4d-4737-9d3a-5f312a9f318a
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_79537ef3-770a-4ede-bcb9-0007aa5f7d2c
stoichiometry: 1.0
species: COPASI12
type: SpeciesReference

COPASI102
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/4991409
name: DDC_Trypta
is encoded by: http://identifiers.org/ncbigene/1644
is: R00685
notes: km and kcat values taken from 4991409 (pig)
fast: false
reversible: false
is: http://identifiers.org/ec-code/4.1.1.28
type: Reaction

COPASI116
type: Reaction
fast: false
is encoded by: http://identifiers.org/ncbigene/4128
modifier: MODEL1310160000#
is: http://identifiers.org/ec-code/1.4.3.4
name: MAOA_Trypta
reversible: false
is described by: http://identifiers.org/pubmed/11754741
is: R02173

http://identifiers.org/biomodels.db/MODEL1310160000#d7329366-63c5-4911-bfab-998724999226
stoichiometry: 1.0
species: COPASI23
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#ee520e3b-61b2-4177-b212-0515004805a9
stoichiometry: 1.0
species: COPASI53
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_5462e568-92b1-4789-a486-f950b4942a69
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_6c75e3d4-b8c6-40c8-bc5f-beb1e0955728
value: 0.043
name: kcat
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_8e6aa663-6727-4e91-a5b7-f5639a97f419
stoichiometry: 1.0
species: COPASI17
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_7f418ed0-c702-4253-9233-dcbfa4f46fd7
value: 0.022
name: Ka
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_0a491c45-a3c4-44ad-80e2-b0bf06fab38a
stoichiometry: 1.0
species: COPASI27
type: SpeciesReference

COPASI39
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_PPi
type: Species

COPASI107
fast: false
modifier: MODEL1310160000#
is encoded by: http://identifiers.org/ncbigene/8564
reversible: false
is: http://identifiers.org/ec-code/1.14.13.9
name: KMO
is described by: http://identifiers.org/pubmed/16973376
is: R01960
type: Reaction

COPASI117
type: Reaction
is described by: http://identifiers.org/pubmed/2949752
modifier: MODEL1310160000#
fast: false
reversible: false
is: R02670
name: Cinnavalinate formation
is: http://identifiers.org/ec-code/1.11.1.6

http://identifiers.org/biomodels.db/MODEL1310160000#_9b26f9aa-c6e9-4194-b584-73a37a0622fa
value: 1.65
name: kcat
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_0ff6964d-d414-4c3c-b2ba-7bb5f36d70d8
stoichiometry: 2.0
species: COPASI33
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_04c7ae2a-86ff-4f94-9abe-25167027fee7
stoichiometry: 1.0
species: COPASI41
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_69dd87ac-9a35-4ecf-86ba-a330e13bfd0b
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

COPASI137
reversible: false
fast: false
is described by: http://identifiers.org/pubmed/18771288
is: http://identifiers.org/ec-code/2.3.1.87
is encoded by: http://identifiers.org/ncbigene/15
name: AANAT_Trypta
is described by: http://identifiers.org/pubmed/15477086
type: Reaction
modifier: MODEL1310160000#

http://identifiers.org/biomodels.db/MODEL1310160000#a5d16cbc-0546-4fb3-8e08-40322cf52a9c
value: 0.016
name: Ka
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_3d2e3b04-6e8c-40ee-9aff-0d3cd9ca6a6a
value: 0.615
name: Kb
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#fb6a10e5-eec2-4c86-8825-169a1136a9be
value: 0.1
name: Ka
type: LocalParameter

COPASI127
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/18620547
name: KAT1_3HKyn
is: R04171
fast: false
reversible: false
type: Reaction
is encoded by: http://identifiers.org/ncbigene/883
is: http://identifiers.org/ec-code/2.6.1.7

COPASI38
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_O2s
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_02e8d605-74e6-41ab-8830-d5ab2c2b35a3
value: 13.57
name: kcat_A
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#c7d07a6d-402f-4967-b41d-7b6003307405
stoichiometry: 1.0
species: COPASI43
type: SpeciesReference

COPASI108
is: R02174
fast: false
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/9852119
type: Reaction
is encoded by: http://identifiers.org/ncbigene/11185
reversible: false
is described by: http://identifiers.org/pubmed/3949799
name: INMT_Trypta
is: http://identifiers.org/ec-code/2.1.1.49

http://identifiers.org/biomodels.db/MODEL1310160000#_0be22e16-fef7-4be4-8659-0980afc4f548
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_42e20777-24e3-4f7c-bca0-e4c511503260
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#fdc796fb-fc9e-4dad-b5b3-df3fd1099951
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

COPASI118
modifier: MODEL1310160000#
type: Reaction
reversible: true
name: Tryptophan_Transport Slc7a5
is described by: http://identifiers.org/pubmed/2872885
is encoded by: http://identifiers.org/ncbigene/8140
fast: false
is: Q01650

COPASI138
type: Reaction
name: TPH2
is described by: http://identifiers.org/pubmed/15663479
is encoded by: http://identifiers.org/ncbigene/121278
is: R01814
is described by: http://identifiers.org/pubmed/19816759
is: http://identifiers.org/ec-code/1.14.16.4
modifier: MODEL1310160000#
fast: false
reversible: false

COPASI37
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_O2
type: Species

COPASI128
name: IDO_Serotonin
is described by: http://identifiers.org/pubmed/19737010
is described by: http://identifiers.org/pubmed/26687
modifier: MODEL1310160000#
type: Reaction
is: R02909
fast: false
reversible: false
is: http://identifiers.org/ec-code/1.13.11.52
is encoded by: http://identifiers.org/ncbigene/3620

http://identifiers.org/biomodels.db/MODEL1310160000#_6f390985-c244-4f73-9ecd-5ff597bacfe0
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

COPASI105
is encoded by: http://identifiers.org/ncbigene/883
type: Reaction
is: http://identifiers.org/ec-code/2.6.1.7
name: KAT1_L-Kyn
is described by: http://identifiers.org/pubmed/18620547
modifier: MODEL1310160000#
fast: false
reversible: false
is: R01956

http://identifiers.org/biomodels.db/MODEL1310160000#e242c196-0f80-4f55-b937-da9b80bc137e
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b22e50af-4a7b-4129-a700-fb83f20fed26
stoichiometry: 1.0
species: COPASI17
type: SpeciesReference

COPASI119
fast: false
name: IDO
type: Reaction
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/19737010
reversible: false
is encoded by: http://identifiers.org/ncbigene/3620
is: R00678
is: http://identifiers.org/ec-code/1.13.11.52
is described by: http://identifiers.org/pubmed/26687

http://identifiers.org/biomodels.db/MODEL1310160000#c8a3b757-a8a2-46b5-9c06-81bac6120223
value: 0.109
name: Kb
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#be07880a-9099-4d9d-8851-890b0cb9ea2f
stoichiometry: 1.0
species: COPASI29
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#d320e303-c17f-479b-b10a-07e7188c6b44
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

COPASI139
is described by: http://identifiers.org/pubmed/2872885
modifier: MODEL1310160000#
is encoded by: http://identifiers.org/ncbigene/23428
fast: false
is: Q9UHI5
name: Tryptophan_Transport Slc7a8
type: Reaction
reversible: true

COPASI125
is encoded by: http://identifiers.org/ncbigene/4128
reversible: false
fast: false
name: MAOA_Serotonin
is: R02908
is: http://identifiers.org/ec-code/1.4.3.4
type: Reaction
modifier: MODEL1310160000#
is described by: http://identifiers.org/pubmed/15848762

http://identifiers.org/biomodels.db/MODEL1310160000#_1332e8a4-5d9b-44c5-9c46-496a5ef5b5bc
value: 0.23
name: kcat_A
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_9885a876-b08e-44f3-9a32-b1cbf6754136
value: 0.013
name: kcat_A
type: LocalParameter

COPASI106
is described by: http://identifiers.org/pubmed/4190298
is encoded by: http://identifiers.org/ncbigene/125061
reversible: false
is: R01959
is: http://identifiers.org/ec-code/3.5.1.9
name: AFMID_FKyn
modifier: MODEL1310160000#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310160000#_33c9ee94-fb0f-4e41-894d-975f89a7f754
value: 3.5
name: kcat_A
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_5ff74790-1759-470f-9836-d58f03063f27
value: 1.0
name: kcat
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_509847a6-2f4e-4628-8f9f-b168f655b2eb
stoichiometry: 2.0
species: COPASI2
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_61beda52-6ef8-403b-aafb-a1c78075034c
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

COPASI89
constant: true
value: 1961.5135498047
name: Transporter_E_T_Slc7a5
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_6920cdb1-fe82-47ee-896c-8c8cc0c53250
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

COPASI49
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_NAcSet
type: Species

COPASI126
modifier: MODEL1310160000#
is: R02911
name: AANAT_Serotonin
reversible: false
is described by: http://identifiers.org/pubmed/15477086
type: Reaction
fast: false
is: http://identifiers.org/ec-code/2.3.1.87
is encoded by: http://identifiers.org/ncbigene/15

http://identifiers.org/biomodels.db/MODEL1310160000#_74167959-a329-4276-a03d-7f9e8a056eba
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#fa38287a-8416-4e3b-950d-8f69554384ea
stoichiometry: 1.0
species: COPASI39
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_39b1f942-4efe-4b0b-9c58-1a4843ee4a72
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_4d78f82c-21b0-4cca-b7c9-daaa37bd905d
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_190fcf86-d55b-4c17-9a92-57af93ad58a0
stoichiometry: 1.0
species: COPASI48
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b81647e2-ad01-40bf-981f-073949754dcb
stoichiometry: 1.0
species: COPASI13
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_29b704cd-3e01-4592-866f-cb5b17eddcef
stoichiometry: 1.0
species: COPASI24
type: SpeciesReference

COPASI45
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_FAA
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#ded75fba-b5ce-4182-9b2c-19289884a17a
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#fea1b726-f1ae-427b-92d7-b00ef7cca206
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

COPASI59
constant: true
value: 9455.1357421875
name: KAT1_E_T
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_11407def-adc1-4cbd-91c9-182ba3c3af84
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b50d6eb2-ed7e-459d-aee1-1597a883eb90
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#c075e6af-0047-4c3f-8338-3af29cce97f4
value: 0.071
name: Kb
type: LocalParameter

COPASI79
constant: true
value: 1.38
name: IMNT_Km_Serotonin
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#e76b464a-35d5-456e-96c1-2b1a3ef436dd
stoichiometry: 1.0
species: COPASI30
type: SpeciesReference

COPASI65
constant: true
value: 1.35
name: AANAT_Km_Serotonin
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_9a8788d4-c637-41c1-88e0-bb3d0c557c25
value: 0.0677
name: Km
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_23b30a91-c94e-4bae-9d26-08d7348b2c4f
value: 0.023
name: Kb
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_76bd5f79-b803-4457-bb57-e72ea067fbd6
stoichiometry: 1.0
species: COPASI45
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_6449001a-80a9-41f6-857f-f1517fcda7fa
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

COPASI46
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_NAAD
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#ed1d1ec9-0eb2-4ada-afe3-33692fa39fa0
stoichiometry: 1.0
species: COPASI45
type: SpeciesReference

COPASI109
is: R02665
type: Reaction
modifier: MODEL1310160000#
is: http://identifiers.org/ec-code/1.13.11.6
is described by: http://identifiers.org/pubmed/12672479
is encoded by: http://identifiers.org/ncbigene/23498
fast: false
name: HAAO
reversible: false

http://identifiers.org/biomodels.db/MODEL1310160000#_47e7c8d0-b157-405e-82ce-1d4c777e3128
stoichiometry: 1.0
species: COPASI15
type: SpeciesReference

COPASI66
constant: true
value: 0.88
name: AANAT_Km_Trypta
type: Parameter

COPASI47
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_Am6sa
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_61fa67e9-1b3c-48cb-8b74-de1cba6adcca
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

COPASI57
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_LKyn_ex
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_67d87fc4-e75e-4de9-a345-df473690db4b
value: 64.0
name: kcat
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#d25842ea-e59d-4b34-9734-d7b7cac25c71
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

COPASI77
constant: true
value: 0.1
name: IDO_Km_Serotonin
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#e727afbe-7e4c-46d4-9b65-a350afd2d71b
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

COPASI67
constant: true
value: 15820.2158203125
name: AFMID_E_T
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_55f0e4c1-fac9-4b3a-a336-c8da6e9c3aad
stoichiometry: 1.0
species: COPASI36
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#fc1cf787-edb7-4270-8e1e-b2ab802abc83
stoichiometry: 1.0
species: COPASI52
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#da582ba4-dd82-4e8d-8e56-844241080c5f
stoichiometry: 1.0
species: COPASI50
type: SpeciesReference

COPASI48
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_5HAc
type: Species

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value: 10308.4
name: E_T
type: LocalParameter

COPASI58
constant: true
value: 1.0
name: scaling
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#c5335133-bddd-4acf-b47c-be5ba4aa585e
stoichiometry: 1.0
species: COPASI52
type: SpeciesReference

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stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

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stoichiometry: 1.0
species: COPASI40
type: SpeciesReference

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stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

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stoichiometry: 1.0
species: COPASI36
type: SpeciesReference

COPASI78
constant: true
value: 4186.5874023438
name: IMNT_E_T
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#c9623cd1-091b-403a-8a51-d1f07d93ac77
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

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stoichiometry: 1.0
species: COPASI15
type: SpeciesReference

COPASI68
constant: true
value: 0.4
name: AFMID_Km_5HFKyn
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_76487bd8-0330-4285-b3ca-403bee6864fe
stoichiometry: 1.0
species: COPASI28
type: SpeciesReference

COPASI55
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_NMSer
type: Species

COPASI41
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_Kyna
type: Species

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stoichiometry: 1.0
species: COPASI47
type: SpeciesReference

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value: 2.2
name: kcat
type: LocalParameter

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stoichiometry: 1.0
species: COPASI52
type: SpeciesReference

COPASI69
constant: true
value: 0.05
name: AFMID_Km_FKyn
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_55459398-08b8-41d3-8dfe-b5f228b2baea
stoichiometry: 1.0
species: COPASI36
type: SpeciesReference

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stoichiometry: 1.0
species: COPASI41
type: SpeciesReference

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value: 3.5
name: kcat_B
type: LocalParameter

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value: 0.0228
name: Ka
type: LocalParameter

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stoichiometry: 1.0
species: COPASI41
type: SpeciesReference

COPASI56
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_Nactrypta
type: Species

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value: 18.6
name: kcat_B
type: LocalParameter

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stoichiometry: 1.0
species: COPASI11
type: SpeciesReference

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stoichiometry: 1.0
species: COPASI39
type: SpeciesReference

COPASI42
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.005
initial amount: NaN
name: Trp_ex
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_17a3dc9e-6ced-4001-820e-fe8b12dfdecf
value: 138709.0
name: E_T
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_6e9f24e0-a9ae-494f-9e17-636c85fcada6
value: 100.0
name: kcat_A
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_67d3d214-d8ec-47b1-8538-cee681df7196
stoichiometry: 1.0
species: COPASI22
type: SpeciesReference

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stoichiometry: 1.0
species: COPASI42
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_3ae29992-07b4-4938-879b-c63a6874dbfa
stoichiometry: 1.0
species: COPASI16
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_3594f915-d05d-4d17-8cdf-142891ea7821
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#f62fefa0-41e1-4a76-87c3-5a3b617fced0
value: 25.9
name: kcat_B
type: LocalParameter

COPASI53
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_F5HKyn
type: Species

COPASI43
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_NaMN
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#e68a906a-d588-41b1-855f-6d4555304b4e
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b2ae5683-61e8-4627-9d93-bfc7dcb994e1
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_91f9c78d-ca3e-4a11-9a2a-0cadfab74a65
stoichiometry: 1.0
species: COPASI57
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_7a09d8c0-8a8e-4b7a-9b12-f54316f1c6df
value: 0.002
name: kcat
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#cfa76e76-bc32-4315-9421-22c90092ad74
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_40f6bf11-5375-4f77-92c0-2cd34d1c3cb9
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#abe69164-092e-4d40-8560-26bde01ebd1c
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_85ea978e-64cd-4bda-8eb4-40da58340601
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b3bb9e4e-be9b-4c49-bc5d-5532ecc5a3b5
value: 0.0011
name: Kb
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_387ed4f3-e591-4aed-9fad-f870b34fc641
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

COPASI54
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_MMTrypta
type: Species

COPASI44
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_PRPP
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_1e84e44c-86e4-438e-b240-445af2c7ca2e
value: 0.57
name: kcat
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_03e58929-d52d-412b-b571-cd0bb5a372fa
stoichiometry: 1.0
species: COPASI3
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_77414be7-ccbe-4f5d-90e8-3282b8fa33eb
stoichiometry: 1.0
species: COPASI10
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#f0f6907d-0aa8-4f69-b7fc-760f1a36a442
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_0e66f336-6241-4567-8e4f-124d8ba81c3c
value: 0.255
name: kcat
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#e8af304d-6fa7-40c0-8167-0099d7df3c1e
stoichiometry: 1.0
species: COPASI4
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_17b5b2d4-684f-42b6-be52-9e0217ce08b8
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#e579bd51-0314-4ee8-ae5c-b56d81b511e3
value: 100.0
name: kcat_A
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#aa79f6d7-a3b0-4a20-b6b9-10e4d917a709
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b14bf765-1778-4d69-b9be-f11981bd6234
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#db65258b-fefe-4111-9042-21449d51a4ef
stoichiometry: 1.0
species: COPASI31
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#dd472cfb-d9ed-4b52-8dba-2436080f5371
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#c535080e-b3bb-4633-8017-f709e3d4ad07
stoichiometry: 1.0
species: COPASI18
type: SpeciesReference

COPASI12
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_AA
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#bd3db543-381c-45a7-83e6-cbad61017ee7
stoichiometry: 1.0
species: COPASI20
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#dc501c0a-c7ab-4a12-b463-92df8bb610ca
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

COPASI71
constant: true
value: 36074.9140625
name: DDC_E_T
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_108c12d3-ea14-4f1f-8a3d-1b291b5aa16a
value: 5.6667E-5
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_37a28421-cb4e-4fb1-8bbf-736bb46008ef
stoichiometry: 1.0
species: COPASI27
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#a5236fa9-2be5-4f6a-9739-7706df8eff52
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_13567860-a341-486e-bcda-7737088901a2
stoichiometry: 1.0
species: COPASI8
type: SpeciesReference

COPASI32
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_H2O
type: Species

COPASI51
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_4de9a301-9b39-423d-88ab-148f48332817
value: 1.4
name: kcat
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_6c68fc5c-68af-4734-adf6-bb27f7c4a3d7
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#f67ac53b-c00d-413b-a2d3-ac23ec55bc2a
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_8a0293f5-c4c7-4a74-a416-f2f7b04f75a1
stoichiometry: 1.0
species: COPASI18
type: SpeciesReference

COPASI90
constant: true
value: 0.019
name: Transporter_Km_Trp_Slc7a5
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_59acd54f-0a94-43a7-881e-54146b87ca36
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_3dec88b0-6714-4a1d-bd7a-e03fc2fcfbb7
value: 2.0
name: e1
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_0f50befc-b70b-4869-9c4b-eb091a4a8610
stoichiometry: 1.0
species: COPASI51
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_62959284-7ecf-4d09-820b-ecd3da2730c9
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

COPASI11
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.9999999518
initial amount: NaN
name: M_AMet
type: Species

COPASI72
constant: true
value: 0.049
name: DDC_Km_5htrp
type: Parameter

COPASI80
constant: true
value: 0.27
name: IMNT_Km_Trypta
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#d5d28278-3b98-4c25-bd36-5d61c26396a0
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

COPASI31
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_H2O2
type: Species

COPASI52
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_Xanth
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_61949e7d-0ab6-4ecc-bb31-6a0e8d27128e
value: 0.4
name: kcat_A
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_7ffe11b4-7aa4-482f-bad1-084923f93ebb
stoichiometry: 1.0
species: COPASI36
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#c2706a80-6497-42e4-85ab-057c0d692e5c
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#d7de7018-bda4-48bb-aa0b-a4127469e06f
value: 0.044
name: kcat_A
type: LocalParameter

COPASI91
constant: true
value: 137204.8125
name: MAOA_E_T
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#e8d663f5-ffb2-4c79-af94-fc7c999f08b9
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

COPASI10
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_L_ALA
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#f80cd38e-ff1b-4c14-a718-74a44276b4e1
value: 1.0
name: kcat
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#cb1e9547-7704-4329-98a8-5e096bb34639
stoichiometry: 1.0
species: COPASI2
type: SpeciesReference

COPASI140
reversible: true
name: Lkynr_Transporter_Slc7a5
is: http://identifiers.org/ncbigene/8140
is described by: http://identifiers.org/pubmed/2872885
type: Reaction
is described by: http://identifiers.org/pubmed/2723766
is: Q01650
modifier: MODEL1310160000#
fast: false

http://identifiers.org/biomodels.db/MODEL1310160000#ec7e9b70-ac64-44b3-a1e8-11093121d49e
stoichiometry: 1.0
species: COPASI33
type: SpeciesReference

COPASI30
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.999999951844375
initial amount: NaN
name: M_CO2
type: Species

COPASI20
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_MTrypta
type: Species

COPASI60
constant: true
value: 7744.3154296875
name: KAT2_E_T
type: Parameter

COPASI92
constant: true
value: 294114.875
name: MAOB_E_T
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_17a02401-c57e-4f5c-be23-9bbac2dd12b1
stoichiometry: 1.0
species: COPASI25
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_4d64ebf4-8000-491f-bd73-369ddad730eb
value: 4.0
name: e2
type: LocalParameter

COPASI70
constant: true
value: 0.211
name: AFMID_Km_FAA
type: Parameter

COPASI50
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.999999951844375
initial amount: NaN
name: M_AcetylCoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_3da193ee-f3a8-451f-9967-d3aafdcad67f
stoichiometry: 2.0
species: COPASI38
type: SpeciesReference

COPASI40
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_Cin
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_026c3fa8-a735-42eb-9bde-70e4918d29e6
value: 2.0
name: kcat_B
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_62a25715-866d-4dff-9f46-2434813a7358
value: 0.037
name: Kb
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_021c7c6b-53ca-4cd2-bf76-f9db83ea80cf
stoichiometry: 1.0
species: COPASI36
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_88b9f90a-30a7-4395-9a05-2dea6f209139
stoichiometry: 1.0
species: COPASI15
type: SpeciesReference

COPASI61
constant: true
value: 15588.2099609375
name: KAT3_E_T
type: Parameter

COPASI75
constant: true
value: 0.045
name: IDO_Km_Trp
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_84d20fa1-f8ab-43d6-b342-5d4cf7607a43
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_01646fc5-ad99-4eac-aa89-050352382c1e
stoichiometry: 1.0
species: COPASI21
type: SpeciesReference

COPASI3
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_5HFKyn
type: Species

COPASI22
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_Serotonin
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#f79f6ac6-dc82-4012-941d-84320a7676b5
stoichiometry: 1.0
species: COPASI39
type: SpeciesReference

COPASI36
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_NH4
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#c5992148-b8a3-4645-abad-9a6a8e3ea0f0
value: 1.1
name: kcat
type: LocalParameter

MODEL1310160000
name: function_4_ACMSD
name: function_4_AANAT_trypta
parameter: COPASI82
parameter: COPASI72
species: COPASI46
parameter: COPASI64
parameter: COPASI92
reaction: COPASI101
name: function_4_IDO_5HT_1
reaction: COPASI120
reaction: COPASI112
name: Slc7a5_LKyn_1
parameter: COPASI94
name: function_4_IDO_SRTN_1
parameter: COPASI86
parameter: COPASI76
substance units: substance
reaction: COPASI113
parameter: COPASI68
species: COPASI45
species: COPASI50
reaction: COPASI105
species: COPASI53
reaction: COPASI124
species: COPASI6
species: COPASI35
parameter: COPASI98
species: COPASI38
name: function_4_IDO_1
name: function_4_KYNU_Lkynr
name: function_4_HAAO_1
parameter: COPASI95
name: Slc7a5_Trp_1
reaction: COPASI117
area units: area
species: COPASI29
species: COPASI34
name: function_4_AADAT_Lkynr_kat3
name: function_4_DDC_5HT
parameter: COPASI99
species: COPASI17
notes: This model is from the paper: Anne-Kristin Stavrum, Ines Heiland, Stefan Schuster, Pål Puntervoll, and Mathias Ziegler. (2013) Model of Tryptophan Metabolism, Readily Scalable using Tissue-Specific Gene Expression Data. J. Biol. Chem. published October 15, 2013 as doi:10.1074/jbc.M113.474908 Summary: Tryptophan is utilised in various metabolic routes including protein synthesis, serotonin and melatonin synthesis and the kynurenine pathway. Perturbations in these pathways have been associated with neurodegenerative diseases and cancer. Here, we present a comprehensive kinetic model of the complex network of human tryptophan metabolism, based upon existing kinetic data for all enzymatic conversions and transporters. By integrating tissue-specific expression data, modelling tryptophan metabolism in liver and brain returned intermediate metabolite concentrations in the physiological range. Sensitivity and metabolic control analyses identified expected key enzymes to govern fluxes in the branches of the network. Combining tissue-specific models revealed a considerable impact of the kynurenine pathway in liver on the concentrations of neuroactive derivatives in the brain. Moreover, using expression data from a cancer study predicted metabolite changes that resembled the experimental observations. We conclude that the combination of the kinetic model with expression data represents a powerful diagnostic tool to predict alterations in tryptophan metabolism. The model is readily scalable to include more tissues, thereby enabling assessment of organismal tryptophan metabolism in health and disease.
species: COPASI27
species: COPASI22
reaction: COPASI121
reaction: COPASI103
species: COPASI15
reaction: COPASI133
name: function_4_AADAT_hLkynr_kat1
reaction: COPASI130
parameter: COPASI81
parameter: COPASI58
reaction: COPASI115
parameter: COPASI63
species: COPASI47
reaction: COPASI107
species: COPASI8
reaction: COPASI134
parameter: COPASI85
parameter: COPASI67
reaction: COPASI119
parameter: COPASI59
species: COPASI51
name: function_4_INMT_trypta
reaction: COPASI116
species: COPASI54
species: COPASI7
species: COPASI36
parameter: COPASI89
name: function_4_TPH1
name: function_4_DDC_trypta
reaction: COPASI109
reaction: COPASI128
species: COPASI42
reaction: COPASI100
name: function_4_AFMID_nform
type: SBMLModel
species: COPASI24
time units: time
name: function_4_KYNU_hLkynr

http://identifiers.org/biomodels.db/MODEL1310160000#bcb1face-567e-437e-adda-dd975af63a7d
stoichiometry: 1.0
species: COPASI50
type: SpeciesReference

COPASI76
constant: true
value: 0.02
name: IDO_Km_5htrp
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_383e884e-8bbd-4659-8d0d-2851e5e82c0e
stoichiometry: 1.0
species: COPASI11
type: SpeciesReference

COPASI62
is described by: http://identifiers.org/pubmed/18620547
constant: true
value: 3.8
name: KAT_Km_3HKyn
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#ca5b7a88-be79-4902-aa34-97844048aff1
value: 15961.5
name: E_T
type: LocalParameter

COPASI2
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_3HAA
type: Species

COPASI21
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_Quin
type: Species

COPASI35
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.03
initial amount: NaN
name: M_NADPH
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_660c6a01-1439-4ae5-818f-c1b72c0eeec8
stoichiometry: 1.0
species: COPASI17
type: SpeciesReference

COPASI73
constant: true
value: 10.0
name: DDC_Km_Trp
type: Parameter

COPASI63
is described by: http://identifiers.org/pubmed/18620547
constant: true
value: 4.7
name: KAT_Km_L-kyn
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_8e153056-5df2-4f6b-b62f-b6fb5dc943ad
stoichiometry: 1.0
species: COPASI43
type: SpeciesReference

COPASI24
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0E-5
initial amount: NaN
name: M_tRNA
type: Species

COPASI5
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_5HKyn
type: Species

COPASI34
constant: true
boundary condition: true
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_NADP
type: Species

COPASI64
constant: true
value: 2770.9680175781
name: AANAT_E_T
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_83f62fcb-620e-40bc-aeba-e0e1d000c442
stoichiometry: 1.0
species: COPASI6
type: SpeciesReference

COPASI74
constant: true
value: 453.4833679199
name: IDO_E_T
type: Parameter

http://identifiers.org/biomodels.db/MODEL1310160000#_565fae97-bbd1-47ce-8c1c-b8fbbc470a99
stoichiometry: 1.0
species: COPASI9
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_89c19b3e-6cb7-4b52-8d91-08c35e417781
value: 2046.74
name: E_T
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_3865940a-df1f-471e-9ce5-98952202f35b
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#c266b60b-8b99-4c12-be9f-f93bbf16ea5d
stoichiometry: 1.0
species: COPASI14
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#b8144ecd-0363-420a-a728-62127ca873b0
value: 2.5E-4
name: k1
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_00e78b65-603d-4eff-ad97-66d5c7d2b4da
value: 4658.65
name: E_T
type: LocalParameter

http://identifiers.org/biomodels.db/MODEL1310160000#_84633fa7-9e1b-498c-98a4-60c81f9934cd
stoichiometry: 1.0
species: COPASI57
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_2aa053a9-d9a7-4eef-859d-305e4826c152
stoichiometry: 1.0
species: COPASI37
type: SpeciesReference

COPASI23
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_Thbpt
type: Species

http://identifiers.org/biomodels.db/MODEL1310160000#_2867e5ff-776e-4937-94e8-b93dab8a951d
stoichiometry: 1.0
species: COPASI32
type: SpeciesReference

http://identifiers.org/biomodels.db/MODEL1310160000#_33579078-3a5f-4588-b202-caafd67043d1
stoichiometry: 1.0
species: COPASI7
type: SpeciesReference

COPASI4
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
name: M_5HTrp
type: Species

COPASI33
constant: true
boundary condition: true
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: M_H
type: Species