metaM trp L e
type: Species
initial concentration: 1.0
is: CHEBI:16828
constant: false
initial amount: NaN
has only substance units: false
name: L-tryptophan
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false
is: SBO:0000247
is: HMDB00929

http://identifiers.org/biomodels.db/MODEL1310110064#_32cf8567_4a59_4e4b_ae75_ed43d683364c
initial concentration: NaN
is: SBO:0000252
type: Species
name: SOD1
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: P00441
is encoded by: hsa:6647

http://identifiers.org/biomodels.db/MODEL1310110064#_ee87853f_c001_45f5_ae0e_2ef19a456ad9
type: Species
is encoded by: hsa:AI348006
has only substance units: false
boundary condition: true
name: _AI348006_1_c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaR r0573
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:438652 NOTES:
reactant: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110064#
name: Cholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7

http://identifiers.org/biomodels.db/MODEL1310110064#_dba03762_ecc1_4016_a3a6_2bc9cb723fcf
initial amount: NaN
has only substance units: false
name: HSD3B7
is encoded by: hsa:80270
constant: false
initial concentration: NaN
is: Q9H2F3
is: SBO:0000252
boundary condition: true
type: Species

metaR r0787
reversible: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#

metaM hdd2coa m
is: CHEBI:61526
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: C05272
is: SBO:0000247
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
is: HMDB03945

metaM inost e
constant: false
is: CHEBI:17268
type: Species
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
name: myo-inositol
is: SBO:0000247
initial amount: NaN
is: HMDB00211
has only substance units: false
initial concentration: 1.0

metaM udpg c
is: C00029
initial concentration: 1.0
is: HMDB00286
is: SBO:0000247
constant: false
type: Species
name: UDPglucose
initial amount: NaN
is: CHEBI:58367
boundary condition: false
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

metaR PIACGT
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
modifier: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.4.1.83
type: Reaction
name: phosphatidylinositol N-acetylglucosaminyltransferase
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.198
is described by: ECO:0000000
product: MODEL1310110064#

metaR ACALDtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
kinetic law: MODEL1310110064#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110064#
name: acetaldehyde mitochondrial diffusion
product: MODEL1310110064#

metaR GLYAMDTRc
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
is version of: http://identifiers.org/ec-code/2.1.4.1
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
name: glycine amidinotransferase (c)
fast: false
is described by: ECO:0000269
product: MODEL1310110064#
modifier: MODEL1310110064#

metaR LCADi
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304
product: MODEL1310110064#
name: lactaldehyde dehydrogenase
type: Reaction
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD

metaM HC02175 c
is: CHEBI:27689
initial concentration: 1.0
has only substance units: false
name: caprate
type: Species
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: SBO:0000247
initial amount: NaN
constant: false

metaR GTHRDt
fast: false
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110064#
name: Glutathione transport into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.

metaR r2111
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_c285ac03_5080_4eeb_9b86_810cac263542
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:26
type: Species
is: SBO:0000252
name: ABP1
is: P19801
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_1c356fed_d1f0_4b33_82c3_a72acbd6fe47
is encoded by: hsa:159
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: ADSS
is: P30520
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b798c873_b0dd_4951_9e45_f806bb54e166
is: SBO:0000252
name: ALDH3B1
initial amount: NaN
has only substance units: false
is: P43353
boundary condition: true
is encoded by: hsa:221
initial concentration: NaN
constant: false
type: Species

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_dbaace3a_bfd6_4637_8c16_d473e6027043
is: Q14435
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: GALNT3
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:2591

metaR HIStN1
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110064#
is described by: ECO:0000269
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: Histidine transport (Na, H coupled)
reversible: true
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_c2b01e51_a280_444d_8069_c2d242d09170
is: SBO:0000252
type: Species
initial concentration: NaN
name: GPX1
is encoded by: hsa:2876
has only substance units: false
boundary condition: true
initial amount: NaN
is: P07203
constant: false

metaM hom L e
is: HMDB00719
name: L-homoserine
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
type: Species
is: SBO:0000247
is: CHEBI:15699
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

metaM CE2838 e
boundary condition: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
constant: false
has only substance units: false
is: C01936
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
initial concentration: 1.0
type: Species
name: maltononaose
initial amount: NaN

metaR URIDK2m
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
name: uridylate kinase (dUMP), mitochondrial
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaM glu5sa m
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: SBO:0000247
is: HMDB02104
constant: false
name: L-Glutamate 5-semialdehyde
initial amount: NaN
is: CHEBI:17232
type: Species
boundary condition: false
is: C01165
has only substance units: false
initial concentration: 1.0

metaR r2193
reactant: MODEL1310110064#
fast: false
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110064#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR r2110
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#

metaR ALAGLNexR
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000304
fast: false
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
modifier: MODEL1310110064#
name: L-alanine/glutamine reversible exchange

metaM retinal cis 9 c
initial amount: NaN
name: all-trans-retinal
boundary condition: false
is: HMDB01358
is: CHEBI:17898
is: SBO:0000247
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
initial concentration: 1.0
has only substance units: false
type: Species

metaR DHCR72r
name: 7-dehydrocholesterol reductase
type: Reaction
product: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.21
modifier: MODEL1310110064#

metaR PEt
reversible: true
product: MODEL1310110064#
name: phosphatidylethanolamine transport
fast: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaM HC02175 e
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27689
name: caprate
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_7481a885_5cf3_4b76_a08e_442c0043d9ac
constant: false
is: Q9H0I9
type: Species
name: TKTL2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:84076

metaM ru5p D c
has only substance units: false
is: CHEBI:58121
is: SBO:0000247
type: Species
name: D-ribulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00618
initial amount: NaN

metaR r0331
is: SBO:0000176
type: Reaction
reactant: MODEL1310110064#
fast: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
kinetic law: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
reversible: false
product: MODEL1310110064#
modifier: MODEL1310110064#

metaR CYSGLUexR
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110064#
is: SBO:0000185
reversible: true
name: L-cysteine/L-glutamine reversible exchanger
fast: false
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000304

metaR SR5ARr
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.99.5
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110064#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reactant: MODEL1310110064#

metaM CE2433 m
initial amount: NaN
is: CHEBI:57795
type: Species
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
has only substance units: false
boundary condition: false
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial concentration: 1.0
is: SBO:0000247

metaR r1010
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
name: Postulated transport reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_e1683510_af85_4102_90a9_3a3999fe1b18
is: SBO:0000252
boundary condition: true
is encoded by: hsa:H77542
initial amount: NaN
type: Species
name: _H77542_1_c
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ab7ae6d9_6f63_4e3c_b288_ade477653e6f
boundary condition: true
name: PCBD1
initial concentration: NaN
initial amount: NaN
is: P61457
is encoded by: hsa:5092
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaM Lcystin c
has only substance units: false
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: L-cystine
initial amount: NaN
is: HMDB00192
boundary condition: false

metaM odecoa m
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
name: Octadecenoyl-CoA (n-C18:1CoA)
type: Species
is: HMDB01322
initial amount: NaN
has only substance units: false
is: CHEBI:57387
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR GULN3D
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
name: L-gulonate 3-dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110064#_ca5d3650_a473_42b8_9af1_0d417f51cb39
type: Species
is encoded by: hsa:50484
constant: false
name: RRM2B
initial concentration: NaN
has only substance units: false
is: Q7LG56
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM retfa e
type: Species
is: CHEBI:15963
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
name: fatty acid retinol
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00508
initial amount: NaN

metaM 44mzym r
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 14-demethyllanosterol
is: CHEBI:18364
is: HMDB01286
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_4b10786a_b7a5_49ae_9b19_646f51a95b16
type: Species
initial amount: NaN
is encoded by: hsa:11112
has only substance units: false
is: SBO:0000252
constant: false
is: P31937
boundary condition: true
initial concentration: NaN
name: HIBADH

metaM aacoa m
initial concentration: 1.0
name: acetoacetyl-CoA(4-)
is: SBO:0000247
boundary condition: false
is: HMDB01484
type: Species
has only substance units: false
is: CHEBI:57286
constant: false
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

http://identifiers.org/biomodels.db/MODEL1310110064#_922f90ed_59d6_4e1b_a734_fa7ebd8f70ef
name: _D87002_1_e
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:D87002
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR r1630
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_9be16a57_8fd0_42b5_8f2a_0f51a118eb88
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8818
name: DPM2
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaM hom L c
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial concentration: 1.0
initial amount: NaN
is: HMDB00719
name: L-homoserine
constant: false
is: CHEBI:15699
boundary condition: false

metaR r0784
is: SBO:0000176
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.1.38

metaR PYRt2m
reactant: MODEL1310110064#
name: pyruvate mitochondrial transport via proton symport
reversible: true
fast: false
modifier: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
product: MODEL1310110064#

metaR BUTt2r
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110064#
name: Butyrate transport via proton symport, reversible
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is: SBO:0000185

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_3b69c2f6_d350_4dda_ac8f_6ac2429ad115
constant: false
boundary condition: true
is: SBO:0000252
name: ENTPD4
is encoded by: hsa:9583
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9Y227

metaR GPDDA1
reactant: MODEL1310110064#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: false
product: MODEL1310110064#
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR

metaR r0570
fast: false
modifier: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.3.2
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
kinetic law: MODEL1310110064#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
reversible: true
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000

metaR r2112
product: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR CYTK4n
reversible: true
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (dCMP,GTP),nuclear

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_4788e261_2a8c_4fd1_b11e_0f8d21b68ae8
initial amount: NaN
constant: false
initial concentration: NaN
name: ENTPD8
is: Q5MY95
is encoded by: hsa:377841
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM r5p c
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
type: Species
is: C00117
has only substance units: false
initial amount: NaN
is: CHEBI:18189
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
constant: false
boundary condition: false
is: SBO:0000247

metaM oxa e
boundary condition: false
name: oxalate(2-)
is: HMDB02329
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ec1accef_271c_48e5_a9fd_da34b3452060
type: Species
initial concentration: NaN
is: Q9BY49
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55825
name: PECR
constant: false
has only substance units: false

metaM cala c
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
boundary condition: false
initial concentration: 1.0
is: HMDB00026
name: N-carbamoyl-beta-alaninate
initial amount: NaN
is: CHEBI:11892
constant: false
has only substance units: false
type: Species
is: SBO:0000247

metaM glyc e
is: HMDB00131
has only substance units: false
is: C00116
name: Glycerol
is: CHEBI:17754
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

http://identifiers.org/biomodels.db/MODEL1310110064#_7fe167c9_774a_4328_8de0_e0ba1aefeca4
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:9167
constant: false
has only substance units: false
is: Q6FGA0
initial amount: NaN
is: SBO:0000252
name: COX7A2L

metaR r2115
reversible: true
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110064#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110064#
type: Reaction
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_a2bf5a11_1d2c_4c4b_98a8_ae9e0a354984
is encoded by: hsa:HG2846-HT2983
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: _HG2846_HT2983_1_c
initial amount: NaN

metaM 10fthf e
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
name: 10-formyltetrahydrofolate(2-)
initial amount: NaN
is: CHEBI:57454
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
is: HMDB00972

http://identifiers.org/biomodels.db/MODEL1310110064#_d519f559_b075_4de0_89c2_2cfe321d309a
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: P05091
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ALDH2
is encoded by: hsa:217

metaR MCCCrm
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
fast: false
modifier: MODEL1310110064#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/6.4.1.4
product: MODEL1310110064#
name: methylcrotonoyl-CoA carboxylase, mitochondrial

metaR MAGt
type: Reaction
is described by: ECO:0000269
product: MODEL1310110064#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
name: monoacylglycerol 2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:

metaR r2196
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110064#
reversible: true

metaR CHSTEROLt1
name: cholesterol intracellular transport
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
product: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000304

metaM crn x
name: L-Carnitine
is: HMDB00062
initial amount: NaN
has only substance units: false
is: C00318
constant: false
is: CHEBI:16347
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_ff5c3f04_7a40_438c_a894_54884f6446a8
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: D9HTE9
is encoded by: hsa:6576
has only substance units: false
boundary condition: true
name: SLC25A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_2591366c_ee79_48c0_bf29_4ad41da318fc
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2653
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: P23434
name: GCSH
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_58eea17d_1dfb_49e4_828a_6afc478d71ee
initial amount: NaN
type: Species
is: SBO:0000252
is: O43292
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:8733
name: GPAA1
constant: false

metaM phe L m
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: SBO:0000247
name: L-phenylalanine
has only substance units: false
is: HMDB00159
boundary condition: false
is: CHEBI:17295
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_43948b58_d84d_4abd_85bd_0370288c477f
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: P07327
name: ADH1A
is: SBO:0000252
is encoded by: hsa:124

http://identifiers.org/biomodels.db/MODEL1310110064#_5691a6de_1d5f_4013_be24_d68e6f1e6eae
constant: false
type: Species
name: GALNT8
is: Q9NY28
has only substance units: false
is encoded by: hsa:26290
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r2114
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_f57b7e0a_fa2f_4ad8_a72b_72d0a7ca150d
name: GPX7
initial concentration: NaN
is: Q96SL4
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:2882
constant: false
has only substance units: false
type: Species

metaM ala B e
is: SBO:0000247
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
boundary condition: false
constant: false
is: CHEBI:16958
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00056

metaR r2009
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction

metaM 3mob m
type: Species
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
constant: false
is: CHEBI:11851
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM xolest2 hs e
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
name: cholesterol ester
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: CHEBI:17002
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_f32e4ed2_02e2_481f_8903_8b7256763359
is encoded by: hsa:57665
type: Species
constant: false
is: SBO:0000252
name: RDH14
initial amount: NaN
is: Q9HBH5
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r2197
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
type: Reaction
modifier: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_a1802cf6_8071_4406_ab9c_46bce62ffb4d
has only substance units: false
name: RPE
is: Q53TV9
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:6120
boundary condition: true
type: Species

metaR UAG4E
is: SBO:0000176
fast: false
reactant: MODEL1310110064#
name: UDP-N-acetylglucosamine 4-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.2
kinetic law: MODEL1310110064#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reversible: true
product: MODEL1310110064#
modifier: MODEL1310110064#

metaR LINKDEG3ly
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
fast: false
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110064#

metaR r0789
fast: false
reactant: MODEL1310110064#
reversible: true
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110064#
type: Reaction

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000000

metaR r2117
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: true

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM trp L c
constant: false
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247
initial amount: NaN
is: CHEBI:16828
initial concentration: 1.0
has only substance units: false
type: Species
name: L-tryptophan
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_15946e30_0b52_4d86_8b81_ba5923edbe8a
is: SBO:0000252
is encoded by: hsa:145226
is: Q96NR8
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: RDH12
boundary condition: true
initial concentration: NaN

metaM 10fthf c
has only substance units: false
constant: false
is: HMDB00972
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234

http://identifiers.org/biomodels.db/MODEL1310110064#_d8e39c34_6229_42e1_bb8e_a4fb456412c5
initial concentration: NaN
boundary condition: true
is: SBO:0000297
constant: false
is encoded by: hsa:84720
name: PIGF:PIGO
is encoded by: hsa:5281
initial amount: NaN
has part: Q6IB04
has only substance units: false
type: Species

metaM glyc c
initial amount: NaN
is: SBO:0000247
is: HMDB00131
name: Glycerol
is: C00116
is: CHEBI:17754
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

metaR CSPG Btly
name: chondroitin sulfate B transport, extracellular to lysosome
kinetic law: MODEL1310110064#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110064#

metaR CHSTEROLt3
reversible: true
fast: false
reactant: MODEL1310110064#
name: cholesterol intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
product: MODEL1310110064#

metaR r2089
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110064#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110064#_5c1bbdee_b8a4_4009_aaa3_1ba6d6801edf
has only substance units: false
constant: false
is encoded by: hsa:4707
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFB1
type: Species
initial concentration: NaN
is: O75438

http://identifiers.org/biomodels.db/MODEL1310110064#_387b5d45_46b5_4101_8484_6f706475857a
is encoded by: hsa:2720
name: GLB1
initial amount: NaN
is: P16278
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_5abb5cc6_71c3_4b27_a530_44d8ed4023b2
is: SBO:0000252
name: GMPPB
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:29925
initial concentration: NaN
constant: false

metaM 7dhf e
name: heptaglutamyl folate (DHF)
boundary condition: false
type: Species
initial amount: NaN
is: HMDB06559
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1

metaM gthox m
initial concentration: 1.0
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false
initial amount: NaN
is: CHEBI:58297
boundary condition: false
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_0ec971e9_d5c5_44e3_85c7_bb7a39f88ea1
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: GALNT4
is: Q8N4A0
is encoded by: hsa:8693
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR PItg
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
name: phosphate transport, Golgi apparatus
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaR FPGS2m
reactant: MODEL1310110064#
fast: false
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.2.17
modifier: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
name: folylpolyglutamate synthetase, mitochondrial
reversible: false

metaR ARSA
reactant: MODEL1310110064#
name: Arylsulfatase A
is: SBO:0000176
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.8
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110064#
product: MODEL1310110064#

metaM gam6p c
constant: false
boundary condition: false
name: D-Glucosamine 6-phosphate
has only substance units: false
is: HMDB01254
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12962
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_8098397a_859e_4892_a82f_e15615fe24aa
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:AL525798
type: Species
has only substance units: false
name: _AL525798_1_c

http://identifiers.org/biomodels.db/MODEL1310110064#_62bb6b22_7b97_48a4_8e4a_0b1a3898ed3d
constant: false
is encoded by: hsa:6531
name: SLC6A3
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: Q01959
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_99c1d506_38ae_4a3b_9988_893ec87d6613
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11136
name: SLC7A9
is: P82251
initial amount: NaN

metaR r0788
modifier: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110064#
is: SBO:0000176
fast: false
reactant: MODEL1310110064#

metaM dcsptn1coa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: HMDB06513
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205483
is: C16173
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
has only substance units: false
constant: false
type: Species
is: SBO:0000247

metaM ala B c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16958
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00056
name: beta-alanine

http://identifiers.org/biomodels.db/MODEL1310110064#_cd6fce97_f737_4850_abb4_6f4fa746b1a7
initial concentration: NaN
constant: false
is encoded by: hsa:2729
is: SBO:0000297
initial amount: NaN
boundary condition: true
name: GCLC:GCLM
is encoded by: hsa:2730
has part: E1CEI4
type: Species
has part: P48507
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_2b91a37b_9bcb_468a_9ea8_e86afb225299
name: CHAT
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1103
boundary condition: true
has only substance units: false
is: Q6LEN6
constant: false

metaR r2116
reversible: true
fast: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_4baaf40a_7793_4406_963a_b4c2e853fa39
boundary condition: true
type: Species
has only substance units: false
name: _AI191472_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:AI191472
is: SBO:0000252
initial amount: NaN

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

metaR PCHOLPm hs
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000269
type: Reaction
name: choline phosphatase
is: SBO:0000176
reversible: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR CHSTEROLt2
fast: false
name: cholesterol intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185

metaR RE0935E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
name: RE0935
is described by: ECO:0000000
reactant: MODEL1310110064#
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17

metaR r2195
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_753bb36a_2b86_4831_a14e_6dc91525d250
is: SBO:0000252
boundary condition: true
name: IDH2
is: P48735
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:3418
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_10de4b4f_565a_4d39_9511_706aa86221cd
initial concentration: NaN
boundary condition: true
name: SLC16A10
constant: false
is encoded by: hsa:117247
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q8TF71
type: Species

metaM malcoa c
constant: false
is: C00083
boundary condition: false
is: CHEBI:57384
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: Malonyl-CoA
is: HMDB01175

http://identifiers.org/biomodels.db/MODEL1310110064#_9a5a4958_ad39_46f5_9b50_604d905b511b
type: Species
initial concentration: NaN
boundary condition: true
is: Q8TDQ7
is encoded by: hsa:132789
constant: false
initial amount: NaN
has only substance units: false
name: GNPDA2
is: SBO:0000252

metaR DRPA
name: deoxyribose-phosphate aldolase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110064#
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_4003c5fc_f491_4bdd_a964_8bcdc8191d1e
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: O00154
is encoded by: hsa:11332
name: ACOT7
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_345f725a_d832_4750_a8af_bb3a6bc2fb4a
is: P48067
boundary condition: true
name: SLC6A9
initial amount: NaN
is encoded by: hsa:6536
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_460392b2_1a3e_427a_a9f8_5fa745532564
type: Species
is encoded by: hsa:F23536
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: _F23536_1_m
is: SBO:0000252

metaR r2087
kinetic law: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM dump c
initial amount: NaN
name: dUMP
is: C00365
type: Species
is: CHEBI:246422
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: HMDB01409
constant: false

metaM 44mctr r
has only substance units: false
constant: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01023
is: CHEBI:17813
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455

metaR r0817
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110064#
is: SBO:0000185
reversible: true
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#

metaR r2119
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110064#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_49973698_5550_4504_8253_d24c2f94d3de
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: O95992
name: CH25H
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9023

metaR r2344
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110064#
reversible: true
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
fast: false
name: Organic anion transporter 5 Utilized transport

metaM mercppyr c
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01368
type: Species
has only substance units: false
is: CHEBI:57678
initial concentration: 1.0
initial amount: NaN
name: 3-mercaptopyruvate
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957

metaR r0686
product: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110064#
reversible: true
fast: false
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_a8347caf_990d_48f6_a19c_52cba0cb6c02
is: SBO:0000252
name: MTHFD2
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:10797
boundary condition: true
has only substance units: false
is: P13995

metaR r1942
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
reversible: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM glx x
is: CHEBI:36655
has only substance units: false
constant: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00119
initial amount: NaN
name: glyoxylate

metaR r1019
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110064#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_9ecaf36b_9e49_4b35_862f_6c1a9bdde9da
boundary condition: true
type: Species
initial concentration: NaN
name: ABCD1
constant: false
is encoded by: hsa:215
is: P33897
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_d0048bca_b9a4_4f92_be29_0edaaf9c1f63
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:6647
is: SBO:0000252
name: SOD1
is: P00441
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_4bcab8bb_0c59_4619_96ea_7afca0f4ec22
initial amount: NaN
name: AMY2B
boundary condition: true
is: SBO:0000252
is: P19961
initial concentration: NaN
type: Species
is encoded by: hsa:280
constant: false
has only substance units: false

metaR r2088
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR TDCHOLAte
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
name: bile acid intracellular transport

metaR r0818
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
name: Transport reaction
reversible: false
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR APAT2rm
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
is: SBO:0000176
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000212
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.19

metaR r2118
modifier: MODEL1310110064#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185

metaR r0899
product: MODEL1310110064#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction
name: Amino acid transporter ATB0+ Facilitated diffusion
reactant: MODEL1310110064#

metaR PNTK
type: Reaction
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: pantothenate kinase
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.1.33
product: MODEL1310110064#
reversible: false
modifier: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000269

metaR GLYt7 211 r
reversible: true
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110064#_a412b77c_6da2_4963_98d7_5ac6ccb888ba
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: O00483
is encoded by: hsa:4697
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: NDUFA4

metaM HC01115 c
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
boundary condition: false
constant: false
name: NeuNGc
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:29025
is: SBO:0000247

metaR r1018
name: Transport reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_f7931a3d_d796_4926_ae2e_263f6029ee9d
name: TK2
boundary condition: true
constant: false
has only substance units: false
is: O00142
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7084
type: Species
initial amount: NaN

metaM itacon m
type: Species
is: CHEBI:17240
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: HMDB02092
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: itaconate(2-)
initial amount: NaN

metaR r2198
modifier: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaR r1682
reactant: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110064#
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000

metaM gpi sig r
boundary condition: false
constant: false
initial amount: NaN
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
has only substance units: false
initial concentration: 1.0
is: CHEBI:58190
type: Species
notes: FORMULA: Y CHARGE: 0
is: HMDB00224
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_c2bac90d_d37a_4b02_b7df_7e89ee0e395e
constant: false
name: _AI620219_1_c
type: Species
has only substance units: false
is encoded by: hsa:AI620219
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r2085
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185

metaM phe L c
is: HMDB00159
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
name: L-phenylalanine
is: SBO:0000247

metaR r0226
is: SBO:0000176
modifier: MODEL1310110064#
reversible: false
fast: false
type: Reaction
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR RE2649M
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
reactant: MODEL1310110064#
name: RE2649
modifier: MODEL1310110064#
reversible: true
is: SBO:0000176

metaR r2346
reactant: MODEL1310110064#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110064#
fast: false

metaR r1730
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
name: Y+LAT2 Utilized transport
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_22bac50b_280f_4a1e_bc20_8a814838be85
name: NOS3
is encoded by: hsa:4846
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: A0S0A7
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d0914982_17bb_425b_a183_eb623ad68606
is encoded by: hsa:763
initial concentration: NaN
has only substance units: false
is: P35218
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: CA5A

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR FAOXC2051843m
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
name: Beta oxidation of fatty acid
reactant: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_e117afc7_7b7a_4c14_86dd_2177eaad5f1e
is: O75874
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: IDH1
constant: false
initial concentration: NaN
is encoded by: hsa:3417

metaR NAGLCAly
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is described by: ECO:0000000
reversible: false
name: N-acetylglucosaminidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110064#
fast: false
type: Reaction

metaM nadp r
is: C00006
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial amount: NaN
constant: false
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
is: CHEBI:58349
type: Species
boundary condition: false
has only substance units: false
is: HMDB00217

metaR r2086
product: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110064#_1be4db62_d53e_4f0e_ab32_deb4f52c5c85
initial amount: NaN
is encoded by: hsa:2687
boundary condition: true
name: GGT5
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P36269
constant: false
type: Species

metaR r2347
fast: false
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110064#

metaR r2007
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
reversible: false
is: SBO:0000185

metaR r1731
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
modifier: MODEL1310110064#
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_0f2a0661_d9c5_4c0f_a915_e13c417ef82d
is: SBO:0000252
type: Species
is encoded by: hsa:NM 013421
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _NM_013421_1_m
constant: false
has only substance units: false

metaR r1945
is described by: ECO:0000000
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110064#

metaR r1380
is described by: ECO:0000000
reversible: true
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
fast: false
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is: SBO:0000176
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_5fe6329e_df50_4873_8498_61d9a4c818ff
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4758
name: NEU1
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: Q99519

metaM thp2c c
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
name: 1-piperideine-6-carboxylate
is: SBO:0000247
is: CHEBI:16987
boundary condition: false
is: HMDB12130
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR r0683
fast: false
modifier: MODEL1310110064#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_ea2098ac_eede_4bb4_95ec_c2a661698008
constant: false
is encoded by: hsa:5230
is: SBO:0000252
name: PGK1
is: P00558
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

metaR r2083
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000

metaM HC00591 m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: 2-oxoglutaramate
is: CHEBI:16769
boundary condition: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

metaR ADKd
reversible: true
product: MODEL1310110064#
name: adenylate kinase (d form)
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#

metaM 3mob e
initial amount: NaN
is: CHEBI:11851
constant: false
is: SBO:0000247
is: HMDB00019
has only substance units: false
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
boundary condition: false
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1

http://identifiers.org/biomodels.db/MODEL1310110064#_da90aaf7_6a73_4621_9605_9a04149fd214
has only substance units: false
name: MPST
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P25325
type: Species
is encoded by: hsa:4357
initial concentration: NaN

metaR DHCR242r
fast: false
name: 24-dehydrocholesterol reductase [Precursor]
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_a08397ee_c12e_4013_8032_e9320dd83a77
boundary condition: true
constant: false
name: PKLR
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5313
is: P30613
initial amount: NaN
initial concentration: NaN

metaM phe L e
name: L-phenylalanine
has only substance units: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:17295
is: HMDB00159
constant: false
initial amount: NaN

metaR ASPt6
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
reversible: false
modifier: MODEL1310110064#
fast: false
name: L-aspartate transport via Na, H symport and K antiport
is described by: ECO:0000269
reactant: MODEL1310110064#
type: Reaction

metaR GK1
reversible: true
name: guanylate kinase (GMP:ATP)
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
is: SBO:0000176

metaR UDPGLCter
product: MODEL1310110064#
is: SBO:0000185
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
type: Reaction
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000

metaR LEUKTRB4t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
name: leukotriene B4 transport
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000185
fast: false

metaM aacoa x
boundary condition: false
name: acetoacetyl-CoA(4-)
constant: false
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57286
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c4086dfd_77d6_442f_b3a9_0f192c37caf1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:60386
is: Q9HC21
initial concentration: NaN
name: SLC25A19

metaM damp c
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58245
initial concentration: 1.0
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: HMDB00905
has only substance units: false
name: dAMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110064#_0e724bb6_8a7e_43d9_b144_65264daa9834
initial concentration: NaN
type: Species
name: HAGHL
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:84264

metaR TCHOLAtx
name: bile acid intracellular transport
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
product: MODEL1310110064#
type: Reaction

metaM oxa m
constant: false
is: SBO:0000247
initial concentration: 1.0
name: oxalate(2-)
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB02329
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_c7819d0f_080c_4e5f_a285_519192a5b9d6
type: Species
initial amount: NaN
boundary condition: true
name: NDUFS4
initial concentration: NaN
is encoded by: hsa:4724
is: O43181
constant: false
has only substance units: false
is: SBO:0000252

metaM glyc m
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
has only substance units: false
initial concentration: 1.0
is: CHEBI:17754
name: Glycerol
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false

metaR GALSIDEtg
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: galactocerebroside intracellular transport
type: Reaction
reactant: MODEL1310110064#
reversible: true

metaR PHCHGSm
is described by: ECO:0000000
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
fast: false
is: SBO:0000176
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reversible: true
kinetic law: MODEL1310110064#

metaR r2341
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction

metaR r2084
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110064#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_3e731a8b_adf4_45e3_a9cb_e4a57aa2f2f3
is encoded by: hsa:AI440329
has only substance units: false
name: _AI440329_1_r
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaR r2001
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pglyc hs e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:60523
boundary condition: false
constant: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
name: phosphatidylglycerol(1-)
initial amount: NaN
type: Species
has only substance units: false

metaR PROt4 2 r
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000006
type: Reaction
reactant: MODEL1310110064#
name: Proline transport (sodium symport) (2:1)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
fast: false
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_d2107eed_2ef5_4408_b616_06cd138c29cf
is encoded by: hsa:U37519
name: _U37519_1_e
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaM CE2705 n
is: HMDB02281
constant: false
is: CHEBI:15374
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
initial amount: NaN
name: quinonoid dihydrobiopterin
type: Species

MODEL1310110064#
species: metaM ppa c
species: metaM thcholstoic c
species: metaM mi1p D c
species: metaM udp c
species: metaM lnlccrn m
species: metaM dlnlcg e
species: metaM ump g
species: metaM gua c
species: metaM dgdp m
species: metaM glyc3p x
species: metaM udpg r
species: metaM Rtotal2 c
species: metaM cit c
species: metaM 56dthm m
stoichiometry: 0.545544
species: metaM o2s m
species: metaM dcamp c
species: metaM thr L c
species: metaM fald c
species: metaM pmtcoa x
species: metaM o2 x
species: metaM oh1 c
species: metaM xol27oh m
species: metaM dhlam m
species: metaM orn c
species: metaM dhf c
stoichiometry: 0.02
species: metaM odecoa c
species: metaM CE5101 m
species: metaM glutcoa m
species: metaM din c
species: metaM gacpail hs c
species: metaM man e
species: metaM thbpt c
species: metaM arab L c
species: metaM etha c
species: metaM sbt D e
scale: -3
species: metaM atp x
species: metaM memgacpail hs r
species: metaM acetol c
species: metaM dgdp c
species: metaM clpn hs c
species: metaM retinal c
stoichiometry: 20.704451
species: metaM mal L e
species: metaM HC02210 c
species: metaM lnlncg e
species: metaM cs c deg3 l
species: metaM leu L e
species: metaM bilirub e
species: metaM thr L e
species: metaM cspg c l
species: metaM 4mop m
species: metaM paps g
stoichiometry: 0.35926
species: metaM HC02205 c
species: metaM urate e
stoichiometry: 4.0
species: metaM CE1617 r
species: metaM 4abut c
species: metaM HC02217 c
species: metaM dtdp n
species: metaM pser L c
species: metaM h l
is: SBO:0000297
species: metaM tchola e
species: metaM HC01444 e
species: metaM dpcoa m
species: metaM glyc R c
species: metaM 5thf e
species: metaM Nacasp m
species: metaM 3hpp m
species: metaM lnlncgcoa m
species: metaM dgmp e
species: metaM ser L e
species: metaM ac e
species: metaM ins c
species: metaM pap g
species: metaM fadh2 c

metaM cmpacna c
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57812
boundary condition: false

metaM ala B m
is: CHEBI:16958
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056

http://identifiers.org/biomodels.db/MODEL1310110064#_0afe6b1b_e377_4ef3_854a_bc2043d635b8
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: O75715
initial concentration: NaN
constant: false
type: Species
name: GPX5
has only substance units: false
is encoded by: hsa:2880

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR ACGALK
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110064#
name: N-acetylgalactosamine kinase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
reversible: false

metaR r1088
name: Active transport
product: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_1b60597c_7430_4b22_9f23_efa6a7f9363d
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q12882
name: DPYD
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1806

http://identifiers.org/biomodels.db/MODEL1310110064#_8818c0d1_0849_4df7_be31_43197ad4131c
type: Species
is encoded by: hsa:51005
is: SBO:0000252
initial concentration: NaN
is: Q9Y303
boundary condition: true
has only substance units: false
initial amount: NaN
name: AMDHD2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_6af3281f_0874_4c1e_8bcc_8cf6a738c07e
initial amount: NaN
name: DLAT
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:1737
is: Q86YI5

metaM dcsptn1crn m
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
boundary condition: false
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB06321

http://identifiers.org/biomodels.db/MODEL1310110064#_2d5d2fe0_1e60_4cf7_9183_63de5a30dbc8
is: P31639
name: SLC5A2
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6524
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_5ce1f83f_f11e_43ed_8bc0_80ca39e29691
type: Species
boundary condition: true
initial amount: NaN
name: _AA526438_1_c
is encoded by: hsa:AA526438
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_4d1373e9_720f_46b8_80cb_8a7cf7a2cd0e
constant: false
is: SBO:0000252
name: XDH
boundary condition: true
initial concentration: NaN
is: P47989
type: Species
initial amount: NaN
is encoded by: hsa:7498
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_061aeded_e7d9_4d43_a22a_54c65db005e1
is encoded by: hsa:622
initial concentration: NaN
name: BDH1
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR r0680
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
modifier: MODEL1310110064#
fast: false

metaM HC01410 m
is: CHEBI:28706
has only substance units: false
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: (2E)-Hexenoyl-CoA
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271

metaM nadp m
initial concentration: 1.0
is: HMDB00217
type: Species
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
boundary condition: false
is: C00006
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
is: SBO:0000247
initial amount: NaN

metaR r2081
reactant: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM 3mob c
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial concentration: 1.0
is: CHEBI:11851
is: HMDB00019
has only substance units: false
name: 3-methyl-2-oxobutanoate

metaR FCLTm
is: SBO:0000176
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.99.1.1
name: Ferrochelatase, mitochondrial
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
type: Reaction
product: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_70a354e9_3313_4c34_8994_f579a6f20223
initial concentration: NaN
name: MCCC2
has only substance units: false
is: Q9HCC0
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:64087
initial amount: NaN
boundary condition: true

metaM 4hpro LT m
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: HMDB00725
name: trans-4-hydroxy-L-proline
is: CHEBI:18095
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: SBO:0000247

metaM ha pre1 l
initial concentration: 1.0
type: Species
is: CHEBI:16126
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_dd4325ce_0a6a_4112_b26e_95ddcb5a444b
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ALDH3B2
is encoded by: hsa:222
type: Species
has only substance units: false
constant: false
is: P48448

metaR IDPtn
reversible: true
name: IDP nuclear transport
kinetic law: MODEL1310110064#
is: SBO:0000185
type: Reaction
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110064#

metaR r1799
reactant: MODEL1310110064#
is described by: ECO:0000000
modifier: MODEL1310110064#
product: MODEL1310110064#
name: Y+LAT2 Utilized transport
fast: false
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM inost c
constant: false
has only substance units: false
name: myo-inositol
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17268
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false
is: HMDB00211

metaM pglyc hs c
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
name: pglyc_hs[c]
is: CHEBI:21338
notes: FORMULA: CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB02704

metaR NACHEXA4ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110064#
fast: false
reversible: false
is: SBO:0000176

metaR r2082
modifier: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR SO4t4 2
reactant: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
fast: false
reversible: true
name: sulfate transport via sodium symport
is described by: ECO:0000269
type: Reaction

metaR PROSTGF2t
kinetic law: MODEL1310110064#
name: prostaglandin uniport
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110064#
is described by: ECO:0000269
fast: false
is: SBO:0000185
reversible: true

metaR PItn
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: phosphate transport, nuclear
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_b7015493_f593_405d_becb_1bf86895c186
name: TKT
initial amount: NaN
type: Species
is: E7EPA7
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7086
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_705c5f60_e177_49c9_999e_e7b503928217
has only substance units: false
boundary condition: true
is: P00813
initial concentration: NaN
name: ADA
initial amount: NaN
is encoded by: hsa:100
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_3e9f316f_608d_4ff1_bf08_02c7bdaf61d7
has only substance units: false
type: Species
is: SBO:0000252
is: Q96CD2
name: PPCDC
boundary condition: true
is encoded by: hsa:60490
constant: false
initial concentration: NaN
initial amount: NaN

metaR r1574
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_dd149229_69f8_4bce_be04_885e28f6333f
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: FOLR1
has only substance units: false
is: P15328
is encoded by: hsa:2348
type: Species

metaR DM atp c
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
kinetic law: MODEL1310110064#
fast: false
name: DM_atp(c)
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_874444b8_7326_4207_9960_cee06a04b6d2
is: SBO:0000252
name: NME4
boundary condition: true
is: O00746
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4833
has only substance units: false
initial concentration: NaN

metaM glyc3p x
initial amount: NaN
type: Species
is: HMDB00126
name: Glycerol 3-phosphate
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
is: C00093

metaM zymst r
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
name: zymosterol
constant: false
is: HMDB06271
is: SBO:0000247
has only substance units: false
is: CHEBI:18252

http://identifiers.org/biomodels.db/MODEL1310110064#_bbccb19c_c896_45cf_8501_cea0b0d07c47
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4357
initial amount: NaN
has only substance units: false
is: P25325
boundary condition: true
type: Species
constant: false
name: MPST

metaR r2092
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000

metaM HC01407 m
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:28276
name: (S)-Hydroxyhexanoyl-CoA
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268

http://identifiers.org/biomodels.db/MODEL1310110064#_29f77d4f_4b47_4a04_b012_6b54a75ad1a2
has only substance units: false
is: SBO:0000252
constant: false
is: Q96E98
name: RHAG
boundary condition: true
is encoded by: hsa:6005
initial amount: NaN
initial concentration: NaN
type: Species

metaR ADK3m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.10
reversible: true
is: SBO:0000176
modifier: MODEL1310110064#
type: Reaction
name: adentylate kinase (GTP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_6b2be01b_c835_41c7_be2c_47a40d5a79d3
is: SBO:0000252
is: Q8N4Q0
name: ZADH2
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:284273

http://identifiers.org/biomodels.db/MODEL1310110064#_15551079_d72a_4a3e_ab2a_f94ef3e8ebcd
name: ASPA
boundary condition: true
is: Q6FH48
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:443

metaR r1575
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_0cd48832_ba9c_46b4_b83d_e7aa25b2e560
initial concentration: NaN
is: O00219
initial amount: NaN
boundary condition: true
is encoded by: hsa:3038
has only substance units: false
constant: false
is: SBO:0000252
name: HAS3
type: Species

metaR RE2649C
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
is: SBO:0000176
modifier: MODEL1310110064#
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
name: RE2649
is described by: ECO:0000000
type: Reaction

metaM gmp c
type: Species
has only substance units: false
is: CHEBI:58115
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP
is: HMDB01397
initial concentration: 1.0
is: C00144
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_33d07465_ea47_4c8a_9299_0dacab9509a6
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:377841
name: ENTPD8
is: Q5MY95
initial concentration: NaN
has only substance units: false
type: Species
constant: false

metaR r2091
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_3dd669fb_cd6e_48d2_9031_52fe933cd1ff
constant: false
is encoded by: hsa:54
type: Species
is: P13686
name: ACP5
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR L LACDcm
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
product: MODEL1310110064#

metaM 3hbcoa m
initial concentration: 1.0
is: HMDB01166
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57316
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ea9e7cb2_f3aa_47a5_8fbc_4d3d34fffb70
is: E5KS60
initial amount: NaN
type: Species
name: SUCLA2
is encoded by: hsa:8803
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_89961cbe_edbb_4aaf_8501_6f5d3310e25d
type: Species
is: SBO:0000252
initial amount: NaN
name: _AI926493_1_c
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AI926493

metaR ITCOAL1m
kinetic law: MODEL1310110064#
type: Reaction
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110064#
reversible: true
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110064#

metaM ivcoa m
has only substance units: false
constant: false
is: CHEBI:57345
name: Isovaleryl-CoA
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01113
boundary condition: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
type: Species

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR r1576
reactant: MODEL1310110064#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
fast: false

metaR r0812
modifier: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR r0679
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110064#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
reversible: true
modifier: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
fast: false

metaR SPODMn
name: superoxide dismutase, nuclear
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR

metaM retinal cis 9 r
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: all-trans-retinal
type: Species
initial amount: NaN

metaR Htr
name: H transporter, endoplasmic reticulum
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_db67fb90_5597_41a8_85ab_a640f854f1db
is encoded by: hsa:10840
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: ALDH1L1
is: O75891
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_86df4cc0_6734_4a02_bb8f_b6fdaedc9cca
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _100128062_1_m
is encoded by: hsa:100128062

metaR r2090
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_ae04cb95_57f3_48a4_b537_65f6205576b0
has only substance units: false
initial amount: NaN
is encoded by: hsa:4860
boundary condition: true
name: PNP
type: Species
is: P00491
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_666dfdcf_b5b0_4408_8988_015908701222
initial concentration: NaN
type: Species
name: _AI653169_1_c
is encoded by: hsa:AI653169
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_2b394cbd_26a5_4e91_b9fc_399cd2804184
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:91703
name: ACY3
is: SBO:0000252
boundary condition: true
is: Q96HD9
initial amount: NaN
constant: false

metaR r0086
modifier: MODEL1310110064#
reversible: false
fast: false
is described by: ECO:0000000
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.3
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_43095501_fed0_402a_8514_5c4665ffb929
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P14618
name: PKM2
constant: false
is encoded by: hsa:5315
boundary condition: true

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_d5c89be6_4647_4335_b07b_83457ccacd0b
is: SBO:0000252
is: Q9NUB1
boundary condition: true
constant: false
name: ACSS1
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:84532
initial concentration: NaN

metaR r1464
type: Reaction
reversible: true
name: Active transport
product: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110064#

metaR TCHOLAte
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
name: bile acid intracellular transport

metaM nicrnt n
notes: FORMULA: C11H12NO9P CHARGE: -2 INCHI: InChI=1S/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/p-2/t7-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: HMDB01132
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57502
name: nicotinate D-ribonucleotide(2-)
has only substance units: false
constant: false

metaR BALAtmr
reversible: true
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
name: Beta-alanine reversible mitochondrial transport (diffusion)
product: MODEL1310110064#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110064#

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR GAPD
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
product: MODEL1310110064#
fast: false
is described by: ECO:0000134
name: glyceraldehyde-3-phosphate dehydrogenase
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.12

metaR SGPL12r
is described by: ECO:0000304
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.1.2.27
reversible: false
name: Sphingosine-1-phosphate lyase
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_efff94bc_5315_48eb_b140_dc8461645709
initial amount: NaN
is encoded by: hsa:55229
is: Q9NVE7
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: PANK4
has only substance units: false
is: SBO:0000252

metaR LNLNCAt
product: MODEL1310110064#
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_bdfff6f5_6eda_4e86_a1d2_5896e92ff37d
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: SLC25A26
initial amount: NaN
is: Q70HW3
is encoded by: hsa:115286
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f4b28ab4_9a38_4d4e_a56e_3e942d71f722
constant: false
is encoded by: hsa:5498
is: P50336
is: SBO:0000252
type: Species
initial amount: NaN
name: PPOX
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_8f4b75e1_5097_4fd9_8e71_ea78400bb54d
has only substance units: false
constant: false
name: COX6C
is: P09669
is encoded by: hsa:1345
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaR r0085
is: SBO:0000176
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
reversible: false
fast: false

metaM Lpipecol x
initial concentration: 1.0
has only substance units: false
is: HMDB00716
boundary condition: false
is: SBO:0000247
constant: false
name: L-pipecolic acid
is: CHEBI:30913
type: Species
initial amount: NaN
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_a837c690_45e7_4fe9_9d4b_4f91d263c087
name: DGKD
type: Species
is: SBO:0000252
is encoded by: hsa:8527
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaM lnlnca l
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:32387
initial concentration: 1.0
constant: false
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
name: alpha-linolenate
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_8f3ce284_5804_41e2_8186_8afca17cc8c2
is encoded by: hsa:1375
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: CPT1B
is: E9PCP2
initial amount: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_722d5477_d632_4f0b_917d_f36922cbabda
boundary condition: true
is encoded by: hsa:53354
initial amount: NaN
name: PANK1
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r1628
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_27d675c0_2829_4b4e_8f31_e9cddfe3133d
is encoded by: hsa:7001
initial amount: NaN
is: P32119
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: PRDX2

metaR H3ETer
modifier: MODEL1310110064#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
is described by: ECO:0000304
reactant: MODEL1310110064#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum

metaR G3PD1
fast: false
modifier: MODEL1310110064#
reversible: true
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.8
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
type: Reaction
kinetic law: MODEL1310110064#

metaR r1578
is: SBO:0000185
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM focytC m
type: Species
name: Ferrocytochrome C
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: CHEBI:16928
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

metaM ddcacoa m
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57375
is: SBO:0000247
is: HMDB03571
boundary condition: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR r1627
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110064#

metaR PGDI
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is version of: http://identifiers.org/ec-code/2.5.1.18
is version of: http://identifiers.org/ec-code/5.3.99.2
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
type: Reaction
name: Prostaglandin-H2 D-isomerase [Precursor]
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_161257fd_f8bf_485d_baa3_5821ed8d7085
initial amount: NaN
name: DGUOK
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:1716
boundary condition: true

metaR r0002
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
name: Active transport
product: MODEL1310110064#

metaR XYLTt
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Xylitol transport via passive diffusion
fast: false
is: SBO:0000185

metaR r1579
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_e89e0cfc_77e8_440b_8842_60641098cb09
boundary condition: true
is: P42765
is: SBO:0000252
constant: false
name: ACAA2
is encoded by: hsa:10449
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_61772273_a929_4f54_a42e_911b6c76854d
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:219
name: ALDH1B1
is: P30837
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_9a09baea_d965_4968_a323_5dd12929afdd
is: Q13057
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: COASY
boundary condition: true
type: Species
constant: false
is encoded by: hsa:80347

metaR r0083
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110064#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#

metaR NTD11
product: MODEL1310110064#
fast: false
type: Reaction
name: 5'-nucleotidase (IMP)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
reversible: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110064#

metaR PPCOAOm
type: Reaction
modifier: MODEL1310110064#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000269

metaM dlnlcgcoa c
type: Species
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:27979
name: dihomo-gamma-linolenyl coenzyme A
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_031ab24c_b7c9_460d_8fce_34565e53b976
constant: false
is encoded by: hsa:5959
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q92781
name: RDH5

http://identifiers.org/biomodels.db/MODEL1310110064#_d616e69b_3084_4f81_a358_c37523ca6898
has only substance units: false
is encoded by: hsa:5334
constant: false
is: SBO:0000252
boundary condition: true
is: Q15111
initial concentration: NaN
name: PLCL1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_669c75b7_f156_483c_ad64_81c92b2a3f13
name: HMOX2
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3163
type: Species
is: SBO:0000252
is: P30519

metaR r1384
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reactant: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
type: Reaction
reversible: true

metaR RE3627M
fast: false
reversible: true
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#
name: RE3627
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_c1f7796b_1fdc_40e9_a670_a2b69800d8f4
type: Species
has only substance units: false
initial amount: NaN
name: NDUFS6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q6IBC4
is encoded by: hsa:4726
constant: false

metaR 3AIBTm
kinetic law: MODEL1310110064#
is described by: ECO:0000304
is: SBO:0000176
name: L-3-aminoisobutyrate transaminase, mitochondrial
reactant: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.19
fast: false
reversible: true
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction

metaR GCC2cm
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
reactant: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoamide), mitochondrial
type: Reaction
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR RE0958E
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
name: RE0958
fast: false
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110064#
reversible: true

metaM CE2705 c
constant: false
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial amount: NaN
name: quinonoid dihydrobiopterin
type: Species
boundary condition: false
is: CHEBI:36781
has only substance units: false
is: SBO:0000247

metaR RE1522M
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
name: RE1522
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110064#_5bea9521_c826_4e5a_b9f8_5b9bce598ad3
is encoded by: hsa:3423
type: Species
is: B4DGD7
initial amount: NaN
name: IDS
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

metaR DNDPt15m
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110064#
is described by: ECO:0000269
reversible: false
name: dUDP transport via dGDP antiport
product: MODEL1310110064#
fast: false
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR PHEMEt
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
name: heme transport
reversible: false
fast: false
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_5ef8558e_1eb9_491b_86b7_1c9a44127f80
has only substance units: false
type: Species
name: NME7
is: SBO:0000252
constant: false
is encoded by: hsa:29922
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9Y5B8

metaR r1629
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_e331954c_97f4_4555_babc_6de4cb66ae7a
is: Q8TCT1
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: PHOSPHO1
is encoded by: hsa:162466
initial amount: NaN

metaR SPODM
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase
reactant: MODEL1310110064#
fast: false
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
product: MODEL1310110064#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_07eb586b_87db_40c0_88a2_9012b5e41490
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:2876
name: GPX1

http://identifiers.org/biomodels.db/MODEL1310110064#_3bed0c6c_fa4e_4fae_a963_f4dcf5952f0d
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: PIGL
is: Q9Y2B2
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9487

metaM andrstandn r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
has only substance units: false
initial concentration: 1.0
constant: false
name: 5alpha-androstane-3,17-dione
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:15994
is: HMDB00899

metaR r0081
modifier: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110064#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
type: Reaction
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.12

metaR SARCStm
fast: false
name: Sarcosine transport (mitochondrial)
reversible: false
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000185

metaR TRIODTHYt2
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
fast: false
type: Reaction
name: T3 transport via facilitated diffusion
modifier: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110064#_9429a44f_f7ed_4781_9b1d_2110e13b8a15
constant: false
is: SBO:0000252
name: PLCD3
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q8N3E9
is encoded by: hsa:113026
boundary condition: true

metaR FADH2tru
reactant: MODEL1310110064#
name: FADH2 transporter, endoplasmic reticulum
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_bf760497_fcef_4428_b7f7_9018fec1ef63
type: Species
initial concentration: NaN
has only substance units: false
name: _AW277253_1_c
is encoded by: hsa:AW277253
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_34afdc05_72b2_43f4_b8ef_c6c157ed5456
type: Species
is: SBO:0000252
name: PLD1
initial concentration: NaN
is: Q59EA4
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:5337

http://identifiers.org/biomodels.db/MODEL1310110064#_0aede693_46cd_44a4_ace2_13e4a70e71f2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: P53004
is encoded by: hsa:644
constant: false
boundary condition: true
name: BLVRA

metaM xylt c
name: xylitol
initial concentration: 1.0
initial amount: NaN
is: HMDB02917
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
type: Species
constant: false
is: SBO:0000247
is: CHEBI:17151
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_13417a7e_646f_4da2_b6d4_772da587fa1f
constant: false
is: Q9NYQ3
is: SBO:0000252
initial amount: NaN
name: HAO2
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51179

http://identifiers.org/biomodels.db/MODEL1310110064#_a7b795ed_f737_4e96_8c3f_565e73e31dd9
constant: false
has only substance units: false
is: Q86XP1
initial concentration: NaN
name: DGKH
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:160851
boundary condition: true

metaR AGDC
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (51005.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.1.25 Confidence Level: 2 AUTHORS: NOTES:acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase
is: SBO:0000176
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.5.1.25
is described by: ECO:0000254
modifier: MODEL1310110064#
fast: false
name: N-acetylglucosamine-6-phosphate deacetylase
reversible: false
kinetic law: MODEL1310110064#

metaM 7dhchsterol r
is: CHEBI:17759
is: HMDB00032
has only substance units: false
initial amount: NaN
constant: false
name: cholesta-5,7-dien-3beta-ol
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164

metaR ITPtn
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: ITP nuclear transport

metaR r0193
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_0f14f241_63b5_4c9a_aee5_d902cf87ead5
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: Q16773
initial concentration: NaN
name: CCBL1
constant: false
is encoded by: hsa:883

metaR 34HPPte
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
reversible: true
type: Reaction
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR r1624
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction

metaR AMETtd
is described by: ECO:0000134
reversible: true
name: diffusion of S-Adenosyl-L-methionine
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185

metaM bamppald c
is: C05665
type: Species
name: beta-Aminopropion aldehyde
constant: false
is: http://identifiers.org/pubchem.compound/7975
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: HMDB01106
boundary condition: false
initial concentration: 1.0

metaR CHOLATEt
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
name: cholate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reactant: MODEL1310110064#
is described by: ECO:0000269
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_e45d0412_78e2_4fe0_9430_996c689166f0
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
type: Species
boundary condition: true
is encoded by: hsa:5277
constant: false
has part: P37287
has only substance units: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:8818

http://identifiers.org/biomodels.db/MODEL1310110064#_3ef06063_808c_4eda_97fe_472bbb11e0f0
is: SBO:0000252
has only substance units: false
is: Q9NRX3
name: NDUFA4L2
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:56901
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_334e58c5_2e81_47e7_bbdc_4890cc5e5054
boundary condition: true
is: P15954
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: COX7C
is encoded by: hsa:1350

metaM acgam6p c
type: Species
is: HMDB01062
initial amount: NaN
is: CHEBI:57513
constant: false
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR HMGLx
product: MODEL1310110064#
is described by: ECO:0000134
modifier: MODEL1310110064#
name: hydroxymethylglutaryl-CoA lyase
fast: false
is version of: http://identifiers.org/ec-code/4.1.3.4
reversible: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
type: Reaction

metaM leuktrD4 c
constant: false
type: Species
boundary condition: false
is: HMDB03080
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28666
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
name: Leukotriene D4

http://identifiers.org/biomodels.db/MODEL1310110064#_1b666268_2a78_4376_81f6_ca975aa6c9a0
initial amount: NaN
constant: false
is: SBO:0000252
name: PIGZ
boundary condition: true
is encoded by: hsa:80235
is: Q86VD9
has only substance units: false
type: Species
initial concentration: NaN

metaM aacoa c
constant: false
is: HMDB01484
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Acetoacetyl-CoA
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: C00332
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57286

metaM xylt e
type: Species
name: xylitol
constant: false
is: HMDB02917
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:17151

metaR r0791
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR PROSTGI2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
product: MODEL1310110064#
is: SBO:0000185
reversible: true
reactant: MODEL1310110064#
fast: false
type: Reaction
kinetic law: MODEL1310110064#
name: Prostaglandin I2 transport

http://identifiers.org/biomodels.db/MODEL1310110064#_df1ca612_768d_41b9_81da_766da8d6c549
initial concentration: NaN
is encoded by: hsa:10786
constant: false
initial amount: NaN
type: Species
name: SLC17A3
is: O00476
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR DGSNtm
type: Reaction
reversible: true
reactant: MODEL1310110064#
name: deoyguanosine transport in mitochondria
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_199d5b90_7158_498b_90ba_6416fd7f0d32
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:60490
is: Q96CD2
initial amount: NaN
has only substance units: false
name: PPCDC
type: Species
boundary condition: true

metaR 3AIBtm
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110064#
reversible: false
name: 3-amino-isobutyrate transport, mitochondrial
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.19
product: MODEL1310110064#

metaR r1623
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_1ebc4b95_9d95_4a34_8000_6e45c794d257
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: SLC23A1
has only substance units: false
initial amount: NaN
is encoded by: hsa:9963
boundary condition: true

metaM 2dr5p c
type: Species
constant: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
boundary condition: false
initial amount: NaN
is: CHEBI:57651
initial concentration: 1.0
has only substance units: false
is: HMDB01031

metaM fald c
type: Species
boundary condition: false
is: CHEBI:16842
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01426
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
initial amount: NaN

metaM dcsptn1crn c
is: HMDB06321
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaR F1Atg
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
name: F1alpha transport (from golgi to lysosome)
type: Reaction
reversible: true
fast: false
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_cce271c3_dce9_4f17_9a5b_e540943c23e4
has only substance units: false
initial amount: NaN
name: NMNAT1
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: B1AN63
is encoded by: hsa:64802

metaR CHOLK
is version of: http://identifiers.org/ec-code/2.7.1.32
product: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Choline kinase
type: Reaction
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_ffe1c639_6a77_469e_9e98_e33de11ba812
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC6A4
is: P31645
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6532

metaR DM dctp m
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dCTP demand
type: Reaction

metaM HC01401 m
initial concentration: 1.0
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
is: CHEBI:27668
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_6936414d_9dda_4f02_9f8f_1e7e7c61c277
is encoded by: hsa:H45672
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _H45672_1_m
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_09aeae90_2c87_4fa5_b700_c7738522a7c6
is: P20132
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: SDS
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10993
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_18f47a7b_21d5_4ad8_b27e_571ec9639204
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:1716
initial amount: NaN
is: E5KSL6
boundary condition: true
type: Species
name: DGUOK

http://identifiers.org/biomodels.db/MODEL1310110064#_53b857c9_225c_42e6_9155_bb619f3627de
type: Species
has only substance units: false
is encoded by: hsa:6319
name: SCD
constant: false
boundary condition: true
is: SBO:0000252
is: O00767
initial amount: NaN
initial concentration: NaN

metaM lnlnca c
is: CHEBI:32387
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: alpha-linolenate
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
is: HMDB01388

http://identifiers.org/biomodels.db/MODEL1310110064#_03baebcb_f6f8_40f9_a5f8_c6900fb3f0d0
boundary condition: true
constant: false
is: P54687
is encoded by: hsa:586
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: BCAT1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_948b78a0_120a_4ce0_ab67_7bfa201e19c3
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: O43181
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4724
name: NDUFS4

metaM 3mb2coa m
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 3-methylbut-2-enoyl-CoA(4-)
boundary condition: false
is: HMDB01493
type: Species
has only substance units: false
is: CHEBI:57344
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069

metaR r1626
fast: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110064#
is described by: ECO:0000000

metaM cs a deg2 l
initial concentration: 1.0
initial amount: NaN
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
boundary condition: false
is: CHEBI:15748
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: HMDB00127

metaR DUDPtn
product: MODEL1310110064#
name: dUDP nuclear transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
reversible: true

metaR DNDPt26m
product: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
reversible: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via dUDP antiport

http://identifiers.org/biomodels.db/MODEL1310110064#_b6bfea09_355e_437a_90e3_d4faf860edde
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR GPIMTer U
is: SBO:0000176
product: MODEL1310110064#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#

metaR RE1533M
is described by: ECO:0000000
is: SBO:0000176
name: RE1533
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_37daab5c_dcde_4709_a58d_5e97d3bf016f
is encoded by: hsa:250
is: P05187
name: ALPP
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_53522e44_b25f_4baa_8a07_8a7f680581d9
is encoded by: hsa:4830
name: NME1:NME2
constant: false
is: SBO:0000297
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaR UMPK4n
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000269
kinetic law: MODEL1310110064#
name: UMP kinase (GTP),nuclear

metaM zymstnl r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
initial amount: NaN
name: 5alpha-cholest-8-en-3beta-ol
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: CHEBI:16608
is: HMDB06841
initial concentration: 1.0
boundary condition: false

metaR r1625
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110064#

metaR CEPTC
reactant: MODEL1310110064#
modifier: MODEL1310110064#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110064#
name: choline phosphotransferase
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.2
product: MODEL1310110064#

metaR r0113
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_91306bdd_123d_4420_b198_cc99e5150375
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: PMM2
is encoded by: hsa:5373
is: O15305
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaM oxa c
name: oxalate(2-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
constant: false
has only substance units: false
is: HMDB02329

http://identifiers.org/biomodels.db/MODEL1310110064#_7febe670_cd27_4d2a_ac72_b9684902a01c
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:64600
initial concentration: NaN
boundary condition: true
is: Q9BZM2
constant: false
is: SBO:0000252
name: PLA2G2F

metaM malttr e
is: CHEBI:27931
initial concentration: 1.0
is: SBO:0000247
is: HMDB01262
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: C01835
name: maltotriose
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false

metaR Htx
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: H transporter, peroxisome
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
reactant: MODEL1310110064#
fast: false

metaR GLCURtly
type: Reaction
reactant: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
name: glucuronate transport into lysososme
kinetic law: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_35bfc0ca_39cb_49f6_bec0_d11a95cf78e0
initial amount: NaN
type: Species
name: ACSL3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:2181
boundary condition: true
is: O95573

metaR r1570
reversible: true
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_5b731e01_9943_4742_92b0_8b78753a7dfe
initial concentration: NaN
type: Species
name: CDS1
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:1040
is: Q92903
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_55b67323_004a_4e29_82c6_c286967f6cd1
boundary condition: true
has only substance units: false
is encoded by: hsa:4717
is: O43677
initial concentration: NaN
is: SBO:0000252
type: Species
name: NDUFC1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b2f535ce_2050_44e8_b2d0_a2d0bc0a733f
is encoded by: hsa:131
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: ADH7
constant: false
is: SBO:0000252
is: P40394
initial concentration: NaN

metaR CYTK5n
type: Reaction
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
reversible: true
modifier: MODEL1310110064#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110064#
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_228eba2a_dd26_4dd6_a7a3_332acf468e2b
name: ALDH7A1
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:501
constant: false
is: E7EPT3
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR FALDH
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
name: formaldehyde dehydrogenase
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD

metaR r2443
reactant: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110064#
type: Reaction
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reversible: false
is: SBO:0000185
product: MODEL1310110064#

metaR 5AOPtm
kinetic law: MODEL1310110064#
fast: false
name: 5-Aminolevulinate mitochondrial transport
is: SBO:0000185
reversible: true
is described by: ECO:0000134
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
reactant: MODEL1310110064#

metaM lnlnca e
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: SBO:0000247
initial concentration: 1.0
is: HMDB01388
is: CHEBI:32387

http://identifiers.org/biomodels.db/MODEL1310110064#_ef4d16de_3178_452f_919c_6d0e8df9e17d
initial concentration: NaN
type: Species
is: Q9Y345
boundary condition: true
is encoded by: hsa:9152
initial amount: NaN
is: SBO:0000252
constant: false
name: SLC6A5
has only substance units: false

metaR r1620
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#

metaR NDPK6n
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

metaR SPODMx
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
name: superoxide dismutase, peroxisome
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_9d8f0fe2_7585_477a_9fde_d28fe890ec75
has only substance units: false
name: ADSL
initial amount: NaN
type: Species
constant: false
is: P30566
initial concentration: NaN
is encoded by: hsa:158
boundary condition: true
is: SBO:0000252

metaR r1571
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
reversible: true

metaR r0196
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110064#
reversible: true
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#

metaM HC01444 e
initial concentration: 1.0
has only substance units: false
type: Species
name: Galactosylglycerol
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:15754

http://identifiers.org/biomodels.db/MODEL1310110064#_f1c3db11_f470_447f_aaa4_edab394ead26
type: Species
boundary condition: true
has only substance units: false
name: RDH13
is: B3KVA3
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:112724

metaR FAEL183
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
name: fatty-acyl-CoA elongation (n-C18:3CoA)
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

http://identifiers.org/biomodels.db/MODEL1310110064#_146007cf_0b19_416b_ada6_d4affa513c0e
is encoded by: hsa:38
name: ACAT1
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: P24752
initial concentration: NaN
has only substance units: false
type: Species

metaM udpglcur c
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
boundary condition: false
is: HMDB00935
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00167
name: UDP-D-glucuronate
is: CHEBI:58052
constant: false
initial amount: NaN

metaR r0795
is: SBO:0000176
name: Spontaneous reaction
is described by: ECO:0000000
modifier: MODEL1310110064#
fast: false
reversible: false
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
kinetic law: MODEL1310110064#

metaM s7p c
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: C05382
type: Species
name: Sedoheptulose 7-phosphate
has only substance units: false
initial concentration: 1.0
is: CHEBI:57483
is: HMDB01068

metaM cys L e
is: HMDB00574
boundary condition: false
initial concentration: 1.0
name: L-cysteine
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
type: Species
constant: false
is: CHEBI:17561
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_a8cef5c3_c4ef_413c_bf0c_000237e997d9
has only substance units: false
initial concentration: NaN
name: NUDT12
is: Q9BQG2
constant: false
is encoded by: hsa:83594
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_090de0c9_b329_4bee_82b1_96422bc22de6
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: O43868
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9153
name: SLC28A2
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_bac3d377_1c8b_4f5e_90a0_6ccfe5a78732
is: SBO:0000297
has only substance units: false
boundary condition: true
has part: E5KS60
name: SUCLG1:SUCLA2
initial amount: NaN
constant: false
is encoded by: hsa:8803
type: Species
initial concentration: NaN

metaR RE1898C
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
name: RE1898

metaM cs e l
constant: false
is: HMDB00062
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
has only substance units: false
is: C00318
initial concentration: 1.0
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16347
type: Species

metaR XOL27OHtm
reversible: true
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
name: 27 hydroxy cholesterol transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_b95c6e01_cb22_4cf8_aaf4_bfc57133d98e
is: P00492
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3251
name: HPRT1
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species

metaR DNDPt38m
product: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
reactant: MODEL1310110064#
name: dUTP transport via dUDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
kinetic law: MODEL1310110064#
fast: false
reversible: false
is: SBO:0000185

metaR CYSSNAT5tc
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_99f04991_71d0_4065_bdfa_397de6704bee
is: Q14376
name: GALE
initial amount: NaN
type: Species
is encoded by: hsa:2582
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaR TDCHOLAtx
reactant: MODEL1310110064#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110064#
name: bile acid intracellular transport
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR r1622
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110064#

metaR GUAPRT
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8
reversible: false
product: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
name: guanine phosphoribosyltransferase
reactant: MODEL1310110064#

metaR r1467
product: MODEL1310110064#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Postulated transport reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_87b30909_a6fc_4f45_83eb_74e1b3ffa737
initial amount: NaN
has only substance units: false
is encoded by: hsa:79623
name: GALNT14
initial concentration: NaN
is: Q96FL9
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaR RDH2a
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.300
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.105
name: retinol dehydrogenase (9-cis,NADPH)
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000269

metaM leuktrD4 e
is: CHEBI:28666
has only substance units: false
is: SBO:0000247
name: Leukotriene D4
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0

metaR r1573
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_4453830f_eefc_4fe4_9e22_c285d879791b
initial amount: NaN
has only substance units: false
boundary condition: true
name: NDUFS1
is encoded by: hsa:4719
initial concentration: NaN
is: SBO:0000252
is: P28331
type: Species
constant: false

metaM biliverd c
type: Species
is: HMDB01008
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: CHEBI:57991
is: SBO:0000247
initial amount: NaN
name: biliverdin(2-)
constant: false

metaR UDPG4E
fast: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
name: UDPglucose 4-epimerase
reactant: MODEL1310110064#
is described by: ECO:0000134
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.2
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_17d6251d_bee6_4df6_a351_646bf12ee753
has only substance units: false
is encoded by: hsa:36
constant: false
name: ACADSB
is: SBO:0000252
type: Species
initial concentration: NaN
is: P45954
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_ace0d6e7_c954_44eb_a286_e35043ce2124
is encoded by: hsa:26289
name: AK5
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_0afbe91e_72dd_4d95_bc2a_381c29599408
initial concentration: NaN
name: AMY1C
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:278
is: P04745
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_2a3097a2_1c94_4cf5_b9b6_0f76357af1fa
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI345944
type: Species
is: SBO:0000252
name: _AI345944_1_m
initial concentration: NaN

metaR DADNt4
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
name: deoxyadenosine transport via diffusion
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_6f1405af_8e88_4b0f_b73c_cafd17492a80
is encoded by: hsa:65010
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q548A7
constant: false
name: SLC26A6
boundary condition: true

metaM 2mp2coa m
constant: false
is: CHEBI:27754
has only substance units: false
boundary condition: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
name: 2-Methylprop-2-enoyl-CoA
is: HMDB01011
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_28292f83_bcc6_47dd_b60c_986763b3796f
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: PYCR1
has only substance units: false
boundary condition: true
is encoded by: hsa:5831
initial amount: NaN
is: A6NFM2

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_605aff8f_fbf3_472d_bd16_79870f8a5c22
initial concentration: NaN
name: ADSSL1
initial amount: NaN
is encoded by: hsa:122622
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B3KTV4

metaM fald e
is: CHEBI:16842
is: SBO:0000247
boundary condition: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01426
initial concentration: 1.0
name: formaldehyde

metaR NDPK6m
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
type: Reaction
fast: false
reversible: true
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM cys L c
type: Species
constant: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial concentration: 1.0
name: L-cysteine
has only substance units: false
is: HMDB00574
is: SBO:0000247
boundary condition: false
is: CHEBI:17561
initial amount: NaN

metaR r1621
reversible: true
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110064#

metaR PAPStg
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
name: 3'-Phosphoadenylyl sufate Golgi transport
kinetic law: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
fast: false
product: MODEL1310110064#
reversible: true
is described by: ECO:0000269

metaR r0797
modifier: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110064#
type: Reaction
fast: false
reactant: MODEL1310110064#
name: glycine N-choloyltransferase EC:2.3.1.65
reversible: true
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR DM ethamp r
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR r2125
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110064#

metaM sphs1p c
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: SBO:0000247
constant: false
is: HMDB00277
name: sphingosine 1-phosphate(1-)
boundary condition: false
is: CHEBI:60119
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR RE3009C
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: false
name: RE3009

metaR r0718
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/1.1.1.181
fast: false
reversible: false
product: MODEL1310110064#

metaM prostgd2 e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
constant: false
name: prostaglandin D2(1-)
has only substance units: false
type: Species
is: HMDB01403
initial amount: NaN
is: SBO:0000247

metaR RE3272N
fast: false
reactant: MODEL1310110064#
name: RE3272
is: SBO:0000176
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reversible: true

metaM cholcoa c
type: Species
initial amount: NaN
name: choloyl-CoA(4-)
is: CHEBI:57373
boundary condition: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01374
has only substance units: false

metaM udp e
is: HMDB00295
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
constant: false
type: Species
name: UDP(3-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:58223
is: SBO:0000247

metaM dgmp c
name: dGMP
initial amount: NaN
constant: false
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: C00362
is: CHEBI:57673

metaR PPNCL3
name: phosphopantothenate-cysteine ligase
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/6.3.2.5
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110064#
modifier: MODEL1310110064#

metaM hista c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: histamium
initial amount: NaN
type: Species
constant: false
is: HMDB00870
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432

metaM btn c
initial amount: NaN
is: C00120
is: CHEBI:3420
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
is: SBO:0000247
initial concentration: 1.0
name: Biotin
type: Species
constant: false
boundary condition: false

metaR r0796
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110064#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
modifier: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_f7e11c93_c98e_4c30_a7d9_adcbea7822a3
has only substance units: false
type: Species
initial concentration: NaN
is: O95168
boundary condition: true
is encoded by: hsa:4710
constant: false
name: NDUFB4
initial amount: NaN
is: SBO:0000252

metaR PMANM
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.8
reversible: true
name: phosphomannomutase
reactant: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/5.4.2.2
is described by: ECO:0000000
product: MODEL1310110064#

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM udp g
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
name: UDP(3-)
type: Species
is: HMDB00295
is: CHEBI:58223
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_54f24717_a5ed_4239_b4d6_a569a81e733f
constant: false
name: IDH2
has only substance units: false
is: P48735
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3418
type: Species

metaM mem2emgacpail prot hs r
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: HMDB00425
type: Species
has only substance units: false
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol-Protein (M4B)

http://identifiers.org/biomodels.db/MODEL1310110064#_1cbebd8e_77eb_4520_a0d1_f47ed13f803e
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: C9JZ62
type: Species
name: TMEM91
boundary condition: true
has only substance units: false
is encoded by: hsa:641649
constant: false

metaR r2124
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
fast: false
modifier: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM CE2434 m
constant: false
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial amount: NaN
is: CHEBI:57795
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR DM fol
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaM sucsal m
initial concentration: 1.0
has only substance units: false
name: Succinic semialdehyde
constant: false
is: HMDB01259
type: Species
is: SBO:0000247
is: CHEBI:57706
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
initial amount: NaN
boundary condition: false

metaM HC01412 m
name: trans-tetradec-2-enoyl-CoA(4-)
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: CHEBI:61405
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_eef64413_f656_4657_b3b7_483c423a44bb
is: H7C5B8
boundary condition: true
initial concentration: NaN
name: NDUFB2
is encoded by: hsa:4708
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaR RE0383C
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
type: Reaction
name: RE0383
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110064#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaR HPYRRy
modifier: MODEL1310110064#
name: Hydroxypyruvate reductase (NADPH)
reversible: false
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.1.1.79
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_19199e69_fbe5_40c5_aee5_3fbb358f30f8
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: _AI373818_1_m
is encoded by: hsa:AI373818

http://identifiers.org/biomodels.db/MODEL1310110064#_b8c24635_c49b_4107_be0e_8555b822399e
is: P54868
is: SBO:0000252
is encoded by: hsa:3158
boundary condition: true
initial concentration: NaN
name: HMGCS2
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_04c1a286_bea6_415f_ba2b_83bb41b17831
initial amount: NaN
is encoded by: hsa:1267
is: P09543
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: CNP
boundary condition: true

metaR LPS4e
is described by: ECO:0000000
is: SBO:0000176
name: phospholipase
type: Reaction
fast: false
kinetic law: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reactant: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.1.4

http://identifiers.org/biomodels.db/MODEL1310110064#_2088370e_9940_4b91_9a0b_e331e026a35c
is: O43674
is encoded by: hsa:4711
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: NDUFB5
initial amount: NaN
has only substance units: false

metaM sphs1p e
is: SBO:0000247
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
is: CHEBI:60119
boundary condition: false
name: sphingosine 1-phosphate(1-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

metaM 5mthf e
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
has only substance units: false
initial amount: NaN
is: CHEBI:3729
is: C00440
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: HMDB01396

metaR r0716
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
reactant: MODEL1310110064#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction

metaR KCC2t
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
product: MODEL1310110064#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransporter (NH4+)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_e39e7fc2_8112_49e6_bc7d_9fd3ddc6420a
is: SBO:0000252
is: Q14542
initial concentration: NaN
initial amount: NaN
name: SLC29A2
boundary condition: true
type: Species
is encoded by: hsa:3177
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_52b4d3c0_9061_4aed_ae3f_7ce3ac7fe490
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: NME1:NME2
is encoded by: hsa:4830
is encoded by: hsa:4831
type: Species
has only substance units: false
constant: false
is: SBO:0000297
has part: P22392
has part: P15531

metaM thr L c
is: HMDB00167
boundary condition: false
name: L-threonine
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
has only substance units: false

metaR r2123
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR FADtru
reversible: false
name: FAD transporter, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b8ae33f3_9eff_4076_9bec_4d71200bdb11
name: CPT1B
is: Q53FV7
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:1375
constant: false
has only substance units: false
initial amount: NaN

metaM thym c
name: Thymine
initial amount: NaN
initial concentration: 1.0
is: HMDB00262
is: C00178
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17821

metaR CMPSASn
is described by: ECO:0000304
type: Reaction
reversible: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: CMP sialic acid synthase, nuclear
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.7.43
is: SBO:0000176

metaM udp c
is: SBO:0000247
is: HMDB00295
name: UDP
is: C00015
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaM dgmp e
initial amount: NaN
constant: false
is: HMDB01044
name: dGMP(2-)
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:57673
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaR r0584
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110064#
is: SBO:0000176
reversible: true
modifier: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_78dca7ac_37a4_4c4a_bcfd_c69ddf4cc289
has only substance units: false
is: A8K761
name: NDUFB10
is encoded by: hsa:4716
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaM btn e
boundary condition: false
is: C00120
is: CHEBI:3420
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
is: HMDB00030
constant: false
type: Species
initial concentration: 1.0
name: Biotin
initial amount: NaN

metaR AMETt2m
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
is: SBO:0000185
product: MODEL1310110064#
is described by: ECO:0000269
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
reactant: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
fast: false
type: Reaction
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_a39a7e60_e820_49b4_9b43_73ea5ab7c4f0
is encoded by: hsa:57379
initial amount: NaN
has only substance units: false
is: Q546Y9
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: AICDA
constant: false
type: Species

metaR H7MTer U
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (80235.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15208306 NOTES:NCD
name: H7 mannosyltransferase, endoplasmic reticulum
type: Reaction
reversible: false
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_a09e4eb8_67de_4a9f_b008_62f65ec54b02
is encoded by: hsa:27232
is: Q14749
is: SBO:0000252
constant: false
name: GNMT
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM dudp c
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: dUDP
initial concentration: 1.0
is: C01346
is: HMDB01000
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_85de6e13_3f7b_4e43_9db7_ad786c72e4e2
is: SBO:0000297
initial amount: NaN
constant: false
is encoded by: hsa:8876
is encoded by: hsa:55350
initial concentration: NaN
is encoded by: hsa:8875
has part: O95497
name: VNN3:VNN2:VNN1
has only substance units: false
boundary condition: true
has part: A8K7W0
type: Species

metaR UDPGALtg
kinetic law: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000269
name: UDP-Gal Golgi transport via CMP antiport
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reversible: true
is: SBO:0000185

metaR SPHINGStl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
name: sphingosine intracellular transport
reactant: MODEL1310110064#

metaR CYTK3n
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110064#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r2122
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#

metaM 3mop c
initial concentration: 1.0
is: CHEBI:28654
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: 3-methyl-2-oxopentanoate
has only substance units: false
is: HMDB00491

metaR r0340
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110064#
product: MODEL1310110064#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38

http://identifiers.org/biomodels.db/MODEL1310110064#_e30c6616_84cf_4e7f_a6f4_52d40c3ae15a
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: P34949
is encoded by: hsa:4351
is: SBO:0000252
name: MPI

metaM HC01223 m
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57340
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM lys L e
type: Species
is: SBO:0000247
name: L-lysinium(1+)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
initial amount: NaN
is: CHEBI:32551
constant: false
boundary condition: false

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
product: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM HC02204 e
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
is: CHEBI:27624
is: SBO:0000247
name: prostaglandin-b1
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR ARACHDCOAtx
type: Reaction
reactant: MODEL1310110064#
fast: false
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
name: fatty acid intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110064#

metaR r2338
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reversible: true
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
fast: false
is: SBO:0000185

metaM dgdp c
is: HMDB00960
type: Species
has only substance units: false
name: dGDP
constant: false
boundary condition: false
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: C00361
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR ASCBt4
type: Reaction
modifier: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: L-ascorbate transport via proton symport
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_9b7b50d0_f324_4d53_ad38_1b7b9b8a060b
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: NNT
initial concentration: NaN
is encoded by: hsa:23530
constant: false
initial amount: NaN

metaM bhb e
type: Species
is: HMDB00011
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
name: (R)-3-hydroxybutyrate
boundary condition: false
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247

metaR r0587
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
fast: false
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1

metaR CORE6GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110064#
reversible: false
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus

metaR LEUt5m
fast: false
name: leucine mitochondrial transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM

metaR S4TASE1ly
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
name: N-acetylgalactosamine-4-sulfatase, lysosomal
type: Reaction
is: SBO:0000176

metaM HC01603 c
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
type: Species
is: C00234
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57454
constant: false

metaR ASPDt6
type: Reaction
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000269
name: D-aspartate transport via Na, H symport and K antiport
reversible: false

metaM 4ppcys m
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
type: Species
boundary condition: false
is: CHEBI:59458
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: HMDB01117
initial amount: NaN

metaR VITD3t2
name: Vitamin D3 uptake
product: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT

http://identifiers.org/biomodels.db/MODEL1310110064#_bb2025fb_2b47_42da_8847_951bc75927d3
type: Species
is encoded by: hsa:7991
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q13454
name: TUSC3
constant: false
boundary condition: true
initial concentration: NaN

metaM btcoa m
is: SBO:0000247
is: C00136
boundary condition: false
has only substance units: false
is: HMDB01088
initial concentration: 1.0
name: Butanoyl-CoA
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
constant: false
is: CHEBI:57371
type: Species

metaM thf e
is: CHEBI:57453
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
type: Species
is: HMDB01846
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false

metaR r2128
product: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_6eb2a57d_ee35_452f_aa66_c69636d765fc
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: Q9UHW9
is: SBO:0000252
name: SLC12A6
is encoded by: hsa:9990

metaR METt4
type: Reaction
name: L-methionine transport in via sodium symport
reversible: false
modifier: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110064#_0917c4e6_9b1e_47ae_bb98_dd49122f2a4b
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ME3
type: Species
is: Q6TCH8
constant: false
is encoded by: hsa:10873

metaR r1953
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM mescoa m
has only substance units: false
type: Species
is: CHEBI:27969
constant: false
initial amount: NaN
is: SBO:0000247
is: C06028
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
initial concentration: 1.0
boundary condition: false
name: Mesaconyl-CoA

metaM gtp c
initial concentration: 1.0
boundary condition: false
is: CHEBI:37565
constant: false
name: GTP
is: C00044
has only substance units: false
is: HMDB01273
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
initial amount: NaN

metaR ALADGLNexR
modifier: MODEL1310110064#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
name: L-alanine/glutamine reversible exchange
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_9439c6e9_9b6c_49fc_9d82_271313b5dd68
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:8398
type: Species
is: A8K460
name: PLA2G6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_24a2c499_b483_48d2_bb60_8a5e4e0afdd2
name: _H53099_1_m
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:H53099
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_94898c29_301b_45fa_98ed_f9d1a6c33646
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: PANK1
is: SBO:0000252
is encoded by: hsa:53354
type: Species

metaR PSSA2 hs
kinetic law: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.29
is: SBO:0000176
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
product: MODEL1310110064#
name: Phosphatidylserine synthase homo sapiens
reversible: true
type: Reaction

metaR SBTR
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
name: D-sorbitol reductase
type: Reaction
product: MODEL1310110064#

metaR GLNtm
is: SBO:0000185
type: Reaction
product: MODEL1310110064#
name: L-glutamine transport via electroneutral transporter
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
fast: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_a853228a_12e3_4b87_8c49_6dc45c99c399
name: PRPS1L1
is encoded by: hsa:221823
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_2ce2cc84_4d2e_431b_9bed_f1eac2f8d3fc
is: Q15392
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:1718
has only substance units: false
name: DHCR24

metaR r2127
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110064#
fast: false
type: Reaction
is described by: ECO:0000000

metaR r0345
is: SBO:0000176
reactant: MODEL1310110064#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110064#
is described by: ECO:0000000
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reversible: true
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110064#

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR r1728
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
reversible: false
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
fast: false

metaR ACCOAtn
reactant: MODEL1310110064#
reversible: true
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185

metaM bhb c
is: SBO:0000247
type: Species
has only substance units: false
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
is: HMDB00011
initial amount: NaN
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
is: CHEBI:10983

metaR DCK2n
type: Reaction
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reactant: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#
fast: false
name: Deoxycytidine kinase, nuclear (UTP)
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_97a93e83_1aa1_4144_8176_e5074c98ddf7
is encoded by: hsa:5236
is: SBO:0000252
type: Species
is: B4DPV0
boundary condition: true
initial amount: NaN
name: PGM1
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_04f8d3a3_2b9a_4aea_bd09_a9d787477bca
is: SBO:0000252
constant: false
boundary condition: true
name: PLCXD2
has only substance units: false
is encoded by: hsa:257068
type: Species
initial amount: NaN
is: Q0VAA5
initial concentration: NaN

metaM cs c l
is: SBO:0000247
initial amount: NaN
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain
has only substance units: false
initial concentration: 1.0
constant: false
is: C00318
boundary condition: false
is: CHEBI:16347
is: HMDB00062
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_6e999059_b89e_412c_9715_33acd9f72c06
name: NDUFA2
is: O43678
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4695
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

metaR GGH 10FTHF6GLUe
reactant: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
is described by: ECO:0000000
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_210cce74_08e3_49e3_94f7_a2722efd53fb
has only substance units: false
boundary condition: true
is encoded by: hsa:23428
initial concentration: NaN
name: SLC7A8
is: Q9UHI5
is: SBO:0000252
type: Species
constant: false
initial amount: NaN

metaR ARACHDt2
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#

metaR RE1447M
reactant: MODEL1310110064#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110064#

metaM prostgd2 c
is: HMDB01403
initial amount: NaN
type: Species
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r2126
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false
reversible: true
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_822e136a_f892_4d1d_91be_36f90fea818a
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:728226
initial amount: NaN
name: _728226_1_e
is: SBO:0000252

metaR SPMTDe
reversible: true
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: SPMTDe
reactant: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_29347f4f_0a6e_445b_830d_9460ad9ae64f
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:376497
initial concentration: NaN
name: SLC27A1
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_1885c2e9_2ca8_4052_b085_c4f3140adc66
is: SBO:0000252
type: Species
boundary condition: true
is: P16260
initial amount: NaN
name: SLC25A16
is encoded by: hsa:8034
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_5eedf02e_3800_445d_a82e_a548bafe4b2b
is encoded by: hsa:728441
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: GGT2
constant: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_d46e2e65_10af_498b_a47e_3d97a78b2f39
constant: false
initial concentration: NaN
has only substance units: false
name: ENPP1
is: P22413
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5167
is: SBO:0000252

metaR SPHK21c
reversible: false
kinetic law: MODEL1310110064#
fast: false
name: sphingosine kinase 2
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.1.91
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110064#_d76e6d5e_3de6_48cf_916a_4d1386f249e6
constant: false
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:51227
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_c9993d5e_7848_4891_91d7_b1d3d38fac4e
is: E1CEI4
name: GCLC
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2729
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_877150f7_a4c2_4287_9700_137379ff31d8
name: _H17063_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:H17063
boundary condition: true
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_956cf7b7_e4e1_4918_a38e_c81f50c1f06b
initial concentration: NaN
is encoded by: hsa:29925
has only substance units: false
type: Species
initial amount: NaN
is: Q9Y5P6
boundary condition: true
is: SBO:0000252
constant: false
name: GMPPB

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_3caeec76_5e56_4a0b_8dce_fda1ac095bf4
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: A8K003
name: PMM1
is encoded by: hsa:5372
boundary condition: true
constant: false

metaM thf c
is: HMDB01846
type: Species
is: CHEBI:57453
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
constant: false
is: C00101

metaM dhf m
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
is: SBO:0000247
is: CHEBI:57451
name: dihydrofolate(2-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaR RE1447N
product: MODEL1310110064#
is described by: ECO:0000000
name: RE1447
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110064#
reversible: true
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176
fast: false

metaR ETHP
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: ethanolamine phosphate phosphatase
type: Reaction
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.3.75
notes: GENE_ASSOCIATION: (162466.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:15175005 NOTES:no high energy phosphate compounds found associated w/ rxn NJ
product: MODEL1310110064#
reversible: false
is: SBO:0000176
fast: false

metaR CSm
reversible: false
reactant: MODEL1310110064#
type: Reaction
fast: false
is described by: ECO:0000134
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.3.1
name: citrate synthase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM HC02203 c
type: Species
boundary condition: false
constant: false
is: CHEBI:27820
has only substance units: false
is: SBO:0000247
name: prostaglandin-a2
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0

metaM thym m
is: CHEBI:17821
has only substance units: false
is: HMDB00262
initial amount: NaN
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
boundary condition: false
name: thymine
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r2097
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR CSPG Ctly
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110064#
name: chondroitin sulfate C transport, extracellular to lysosome
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_00cd61cc_ccfb_44ad_8bd2_4358d997f2a5
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:3417
name: IDH1
is: O75874
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR r0940
name: Free diffusion
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110064#

metaR r2334
kinetic law: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110064#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_4e304dc8_c81c_4ce5_8ae0_4acbc32ac401
initial concentration: NaN
is encoded by: hsa:1109
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is: P17516
name: AKR1C4
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_c3948468_24c2_4993_adc0_31e1dc893ed3
initial amount: NaN
has only substance units: false
name: MGLL
initial concentration: NaN
is encoded by: hsa:11343
constant: false
type: Species
is: SBO:0000252
is: B2ZGL7
boundary condition: true

metaM pa hs c
has only substance units: false
constant: false
type: Species
name: phosphatidate(2-)
boundary condition: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial amount: NaN
is: CHEBI:57739
is: SBO:0000247
initial concentration: 1.0

metaR r2098
kinetic law: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
reactant: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_3ec40ae6_4211_4600_9b68_908237c76575
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10423
constant: false
has only substance units: false
is: O14735
type: Species
name: CDIPT

metaR RE2651R
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110064#
is: SBO:0000176
name: RE2651
type: Reaction
reversible: true
fast: false

metaR GLCAASE5ly
type: Reaction
reversible: false
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
kinetic law: MODEL1310110064#
fast: false

metaM srtn c
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: serotonin(1+)
initial concentration: 1.0
is: HMDB00259
is: CHEBI:350546
initial amount: NaN
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
constant: false

metaM HC00695 m
has only substance units: false
name: S-Succinyldihydrolipoamide
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: CHEBI:17432
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

metaR ACGAMK
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.59
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
reactant: MODEL1310110064#
name: N-acetylglucosamine kinase
fast: false
modifier: MODEL1310110064#

metaR RE1903R
fast: false
reversible: true
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
reactant: MODEL1310110064#
name: RE1903
is: SBO:0000176
kinetic law: MODEL1310110064#

metaR r0941
is: SBO:0000185
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
name: Free diffusion
product: MODEL1310110064#

metaM acnam c
is: CHEBI:35418
is: HMDB00230
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: N-acetylneuraminate
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0

metaR r2335
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR r2019
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
modifier: MODEL1310110064#
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_4a4d80ce_974e_4666_8426_31ab7cdbe557
is: Q9Y6T7
has only substance units: false
is encoded by: hsa:1607
constant: false
name: DGKB
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_2fd51a14_ca90_4783_9da7_66888f684029
name: GUK1
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q16774
is encoded by: hsa:2987
has only substance units: false
boundary condition: true

metaR r2332
fast: false
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1692
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
product: MODEL1310110064#
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000

metaM HC02203 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:27820
initial amount: NaN
has only substance units: false
name: prostaglandin-a2
type: Species

metaR r2099
kinetic law: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM gtp m
boundary condition: false
is: C00044
has only substance units: false
initial amount: NaN
name: GTP
is: HMDB01273
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaM dgmp m
name: dGMP
is: CHEBI:57673
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01044
is: SBO:0000247
is: C00362
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial amount: NaN
constant: false
boundary condition: false

metaR r1008
is described by: ECO:0000000
name: Facilitated diffusion
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#

metaR RE2626C
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
name: RE2626
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
is: SBO:0000176

metaM 7dhchsterol c
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: HMDB00032
is: CHEBI:17759
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: cholesta-5,7-dien-3beta-ol

metaR r0603
is described by: ECO:0000000
product: MODEL1310110064#
modifier: MODEL1310110064#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.12
reversible: true
type: Reaction

metaR r0829
is version of: http://identifiers.org/ec-code/4.1.1.37
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110064#
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110064#

metaM lnlccoa r
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/5462164
initial concentration: 1.0
is: SBO:0000247
name: linoleic coenzyme A
constant: false
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
boundary condition: false
is: HMDB01064

metaR CGLYt3 2
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000304
product: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
is: SBO:0000185
name: Cys-Gly transport in via proton symport
fast: false
type: Reaction
reversible: false

metaR r0236
is described by: ECO:0000000
product: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: true
fast: false
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is: SBO:0000176
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:

metaR r2018
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
reversible: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#

metaR ILETAm
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
name: isoleucine transaminase, mitochondrial
product: MODEL1310110064#

metaM lac D c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16004
name: (R)-lactate
constant: false
is: HMDB01311

metaM gtp n
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
name: GTP(4-)
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_d96b6f43_9014_4914_9046_abd6da93a76e
initial concentration: NaN
constant: false
name: PCBD1
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5092
initial amount: NaN
type: Species

metaR RDH1
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
reactant: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.315
type: Reaction
reversible: true
is: SBO:0000176
name: retinol dehydrogenase (all-trans)

metaR r1007
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
type: Reaction
reversible: true
name: Facilitated diffusion
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000

metaR SFGTH
kinetic law: MODEL1310110064#
reversible: true
name: S-Formylglutathione hydralase
is: SBO:0000176
modifier: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.2.12
is described by: ECO:0000269

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_6500d6dc_b280_479e_92be_622c09c94767
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:84720
has only substance units: false
name: PIGO
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_e49ff9ee_93a6_479b_8dad_6b6edcdf8de0
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110064#_000a2bed_2b94_4e6b_91af_833a3c4bc21f
name: LDHAL6A
initial concentration: NaN
has only substance units: false
constant: false
is: Q6ZMR3
is encoded by: hsa:160287
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_aaeb5cb1_5157_40ee_bb52_fdf9375472db
name: HSD17B4
type: Species
is encoded by: hsa:3295
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: E9PB82
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_3fd14cd2_1d1e_4134_8429_1e000c049776
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9Y6K8
constant: false
boundary condition: true
is encoded by: hsa:26289
name: AK5
type: Species
has only substance units: false

metaR r2017
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r0604
fast: false
modifier: MODEL1310110064#
is: SBO:0000176
reversible: false
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
kinetic law: MODEL1310110064#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is described by: ECO:0000000
reactant: MODEL1310110064#

metaR UDPGLCAter
product: MODEL1310110064#
type: Reaction
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
is: SBO:0000185
fast: false

metaR r2333
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR ABTD
reversible: true
type: Reaction
name: L-arabinitol 4-dehydrogenase
fast: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_073fbd9d_1332_4137_aaee_5d8ba7c33da3
constant: false
is: Q9BV79
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: MECR
initial concentration: NaN
is encoded by: hsa:51102
has only substance units: false

metaR r2093
kinetic law: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM Lkynr c
type: Species
is: CHEBI:16946
is: HMDB00684
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: SBO:0000247
name: L-kynurenine
initial amount: NaN
constant: false

metaR RDH2
name: retinol dehydrogenase (9-cis,NADH)
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
reversible: true
product: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000176

metaR RE2659R
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110064#
type: Reaction
name: RE2659
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#

metaR ADSL1
modifier: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.3.2.2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110064#
type: Reaction
name: adenylosuccinate lyase
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110064#
reversible: false

metaM glu L c
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985
name: L-glutamate(1-)
initial amount: NaN
initial concentration: 1.0
is: HMDB00148
has only substance units: false

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR r2330
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR H2Otp
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
name: H2O transport, peroxisomal
reversible: true
is: SBO:0000185

metaM hmgcoa x
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
boundary condition: false
is: CHEBI:15467
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b043a32b_b6c2_439c_9633_5eb695980f5b
boundary condition: true
is encoded by: hsa:766
initial concentration: NaN
is: Q86YU0
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: CA7
is: SBO:0000252

metaR r1722
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185

metaR r0944
product: MODEL1310110064#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
name: Active transport

metaM thf l
constant: false
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
initial concentration: 1.0
is: CHEBI:57453
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_f74d8992_3b17_4d6f_ba7a_3b37312551b2
is: Q16760
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8527
initial amount: NaN
name: DGKD
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR CTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110064#
name: CTP diffusion in nucleus
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaM paps g
type: Species
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: CHEBI:58339
boundary condition: false
is: HMDB01134
constant: false
is: SBO:0000247

metaR RDH3
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
modifier: MODEL1310110064#
is described by: ECO:0000269
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (11-cis,NADH)
type: Reaction
reversible: true

metaM 2maacoa m
boundary condition: false
name: 2-methylacetoacetyl-CoA(4-)
is: CHEBI:57335
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
constant: false
initial amount: NaN
is: HMDB01157

metaM lgt S c
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
name: (R)-S-lactoylglutathionate(1-)
is: HMDB01066
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57474
has only substance units: false
type: Species
initial amount: NaN

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR NACASPtm
is: SBO:0000185
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
reversible: false
fast: false
kinetic law: MODEL1310110064#
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)

metaM g1p c
name: D-Glucose 1-phosphate
is: SBO:0000247
initial amount: NaN
is: C00103
has only substance units: false
is: CHEBI:58601
type: Species
is: HMDB01586
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103

http://identifiers.org/biomodels.db/MODEL1310110064#_44d8127d_d027_4eaa_b12f_f3c8ef54b3bd
is encoded by: hsa:1632
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ECI1
constant: false
is: P42126

metaM udpglcur r
is: HMDB00935
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: C00167
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
type: Species
name: UDP-D-glucuronate
is: CHEBI:58052

metaR r2331
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185

metaR r2094
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110064#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM lnlccoa m
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064

http://identifiers.org/biomodels.db/MODEL1310110064#_14b451dc_8e74_4f17_8a40_dc52bd5b33c9
initial amount: NaN
is encoded by: hsa:427
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q13510
boundary condition: true
is: SBO:0000252
name: ASAH1

http://identifiers.org/biomodels.db/MODEL1310110064#_2356a903_b4eb_46d5_90f0_f166679a206c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: HADHA
initial amount: NaN
has only substance units: false
is: E9KL44
is encoded by: hsa:3030

http://identifiers.org/biomodels.db/MODEL1310110064#_5958f3a7_a198_4d2e_b319_556ce7809c3e
name: IDUA
constant: false
is: P35475
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3425
is: SBO:0000252
has only substance units: false

metaR r1154
kinetic law: MODEL1310110064#
name: EC:1.2.7.2
reversible: true
product: MODEL1310110064#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
type: Reaction
reactant: MODEL1310110064#

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaM thf m
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01846
initial concentration: 1.0
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
name: 5,6,7,8-Tetrahydrofolate
is: C00101
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:57453

http://identifiers.org/biomodels.db/MODEL1310110064#_e133f79b_e83c_419a_8ec7_779a586a643c
constant: false
type: Species
boundary condition: true
name: _AI972237_1_c
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI972237
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_d2386848_2532_41f7_99e4_e2e2d5ae58b6
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:T83654
name: _T83654_1_e
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM cpppg3 c
type: Species
boundary condition: false
is: C03263
is: SBO:0000247
constant: false
has only substance units: false
name: Coproporphyrinogen III
is: CHEBI:57309
initial concentration: 1.0
is: HMDB01261
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
initial amount: NaN

metaM lys L c
initial amount: NaN
constant: false
is: HMDB00182
type: Species
name: L-lysinium(1+)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_6fc1bc10_ac96_40ec_a16e_c18d2fcb7564
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5332
name: PLCB4
initial concentration: NaN
is: E2QRH8
initial amount: NaN
boundary condition: true
constant: false

metaR PROSTGD2t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#

metaR r2095
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_a364e1db_f8ac_42e8_96b4_0f41027a9a02
is: Q7L266
is: SBO:0000252
name: ASRGL1
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:80150
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_458cc366_0d8b_48ed_86c1_f2d7bf1712f7
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: PTDSS2
constant: false
is: Q9BVG9
is encoded by: hsa:81490
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_bf21d408_046b_4dbb_8351_13f28ac2f843
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1606
name: DGKA
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
is: P23743

metaR H2Otn
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
name: H2O transport, nuclear
is described by: ECO:0000000
type: Reaction

metaM glu L e
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:29985
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
name: L-glutamate(1-)
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM gumtchol e
notes: FORMULA: C2760026H5060045NO2530007S CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
name: guar gum-taurocholic acid complex
is: CHEBI:57449

metaR HOXG
is version of: http://identifiers.org/ec-code/1.14.99.3
modifier: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
reactant: MODEL1310110064#
name: Heme oxygenase 1
is described by: ECO:0000134
type: Reaction
reversible: false
kinetic law: MODEL1310110064#
fast: false

metaM paps c
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: CHEBI:58339
is: HMDB01134

metaM dhf c
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: C00415
initial amount: NaN
initial concentration: 1.0
is: HMDB01056
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57451
name: 7,8-Dihydrofolate

metaR r0942
reactant: MODEL1310110064#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
reversible: true

metaM HC00319 m
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:30794
name: Malonate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_990ffb30_6216_42c6_a4b4_fc1f99200e03
is: SBO:0000252
type: Species
name: GLUD2
is encoded by: hsa:2747
constant: false
boundary condition: true
has only substance units: false
is: P49448
initial concentration: NaN
initial amount: NaN

metaR r1156
reactant: MODEL1310110064#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110064#

metaR r0580
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.7
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
reversible: true
type: Reaction
fast: false
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
kinetic law: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#

metaM dhf e
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57451
type: Species
is: SBO:0000247
name: dihydrofolate(2-)
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056

metaM bhb m
is: CHEBI:10983
type: Species
initial amount: NaN
has only substance units: false
name: (R)-3-hydroxybutyrate
constant: false
is: HMDB00011
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
initial concentration: 1.0

metaR r2096
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
is described by: ECO:0000000
modifier: MODEL1310110064#
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_50e39f89_d12d_48ae_9972_b24f43838ca1
has only substance units: false
is: SBO:0000252
name: PYCR1
boundary condition: true
is encoded by: hsa:5831
is: P32322
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR RTOTAL2t
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#
name: RTOTAL2 transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_0ad5acb8_a56d_4a76_9698_b9d2f32769c4
is encoded by: hsa:9061
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: O43252
initial amount: NaN
initial concentration: NaN
name: PAPSS1

metaR H2Otm
fast: false
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
reactant: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
name: H2O transport, mitochondrial
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110064#

metaR LINKDEG4ly
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110064#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110064#_e3592bd2_9c52_41e0_b15f_26755b5c8ffa
is: SBO:0000252
has only substance units: false
is encoded by: hsa:284098
constant: false
is: Q7Z7B1
name: PIGW
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaM glyb c
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00043
has only substance units: false
initial concentration: 1.0
is: CHEBI:17750
name: glycine betaine

metaR PE HSter
name: phosphatidylethanolamine scramblase
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
type: Reaction
reactant: MODEL1310110064#
reversible: true

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR HPYRR2x
is described by: ECO:0000304
product: MODEL1310110064#
name: hydroxypyruvate reductase (NADH)
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.2.4
is: SBO:0000176
reversible: false

metaR Htg
is: SBO:0000185
product: MODEL1310110064#
reactant: MODEL1310110064#
name: proton diffusion (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
reversible: true

metaM hista e
type: Species
boundary condition: false
is: HMDB00870
is: SBO:0000247
name: histamium
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432

metaR ABTArm
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.19
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
type: Reaction

metaR r0009
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_0b2dcda4_ae34_4481_96a8_00098a78bde4
has only substance units: false
type: Species
is: Q9BZ23
is encoded by: hsa:80025
initial concentration: NaN
initial amount: NaN
name: PANK2
boundary condition: true
is: SBO:0000252
constant: false

metaM ps hs e
boundary condition: false
constant: false
is: CHEBI:18303
type: Species
is: SBO:0000247
initial amount: NaN
name: phosphatidylserine
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006

http://identifiers.org/biomodels.db/MODEL1310110064#_ce19d2b4_df6e_4b22_b2b9_d2de19489953
is: SBO:0000252
name: ACOT2
is: P49753
is encoded by: hsa:10965
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaM taur x
is: CHEBI:15891
has only substance units: false
is: HMDB00251
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
name: taurine
initial amount: NaN

metaM so4 e
is: CHEBI:16189
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: sulfate
boundary condition: false
is: HMDB01448
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false

metaR r1588
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
reactant: MODEL1310110064#

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR MERCPLACCYSt
product: MODEL1310110064#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular

metaM cmpacna n
type: Species
initial concentration: 1.0
is: CHEBI:57812
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
is: HMDB01176
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

http://identifiers.org/biomodels.db/MODEL1310110064#_f5c0d76e_19cb_479f_ae2e_b2f408a3d776
is: SBO:0000252
initial amount: NaN
is: Q9NVS9
initial concentration: NaN
name: PNPO
has only substance units: false
boundary condition: true
is encoded by: hsa:55163
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f8cf76df_2465_45ee_9935_11c093680976
initial concentration: NaN
is: Q53H96
name: PYCRL
boundary condition: true
type: Species
is encoded by: hsa:65263
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaM udpacgal l
is: CHEBI:57847
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
constant: false
is: HMDB00304
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)

metaM HC00319 c
name: Malonate
constant: false
is: CHEBI:30794
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_96264300_639c_42a6_b621_da8c8ec1ce81
is: SBO:0000252
constant: false
is encoded by: hsa:51205
boundary condition: true
initial amount: NaN
name: ACP6
is: Q9NPH0
initial concentration: NaN
has only substance units: false
type: Species

metaR CHOLtu
name: Choline uniport
product: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
reversible: true

metaR r1589
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000185

metaM dgtp c
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
is: HMDB01440
initial concentration: 1.0
initial amount: NaN
is: C00286
is: CHEBI:16497
is: SBO:0000247
type: Species
constant: false
name: dGTP

http://identifiers.org/biomodels.db/MODEL1310110064#_23a45514_d038_4886_9144_55e297597fce
initial concentration: NaN
initial amount: NaN
name: ARSB
is encoded by: hsa:411
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: A8K4A0

http://identifiers.org/biomodels.db/MODEL1310110064#_d680eb9f_2198_49bf_9cc0_a97222dbb1f5
is: SBO:0000252
type: Species
initial amount: NaN
name: PLA2G2A
initial concentration: NaN
has only substance units: false
is: P14555
constant: false
is encoded by: hsa:5320
boundary condition: true

metaR r2012
modifier: MODEL1310110064#
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110064#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_bdf7801d_ef69_4834_9638_14aa20ee0637
name: CHKB
has only substance units: false
is encoded by: hsa:1120
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: Q9Y259

http://identifiers.org/biomodels.db/MODEL1310110064#_af11c4cd_c097_469f_a1ff_c371e18e9bd6
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AD000092
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AD000092_1_c

metaR r1377
is: SBO:0000176
reversible: true
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110064#

metaR ALR3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
name: aldose reductase (acetol)
is described by: ECO:0000269
reactant: MODEL1310110064#

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_17df79bb_46cf_4081_a210_eff20ea89b80
type: Species
constant: false
is encoded by: hsa:7296
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: TXNRD1

http://identifiers.org/biomodels.db/MODEL1310110064#_680e9ba1_c563_4d83_9217_1650f4ae721f
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: ST20
boundary condition: true
initial amount: NaN
is encoded by: hsa:400410
initial concentration: NaN
is: Q9HBF5

metaM dump m
is: CHEBI:246422
initial concentration: 1.0
is: HMDB01409
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
constant: false
is: SBO:0000247
name: dUMP(2-)
initial amount: NaN
type: Species

metaR r1586
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM so4 c
type: Species
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
initial amount: NaN
name: sulfate
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false

metaR G5SADrm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
product: MODEL1310110064#
is described by: ECO:0000000
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
reactant: MODEL1310110064#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110064#

metaR SERGLNexR
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110064#
is described by: ECO:0000304
name: L-Serine/Glutamine reversible exchange
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_97d7634a_5cce_4f2b_86f8_ead6b32ecf3d
is encoded by: hsa:50808
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: AK3
is: E7ET30

metaR r1378
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_fef2f059_f30e_4a91_b374_921188909285
type: Species
initial amount: NaN
name: NDUFS8
has only substance units: false
constant: false
is encoded by: hsa:4728
initial concentration: NaN
is: O00217
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_bfd2748c_e5a5_4bab_81d6_7d8cdb8533e2
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: B1AM93
initial concentration: NaN
is encoded by: hsa:4702
constant: false
name: NDUFA8
has only substance units: false

metaM udpgal c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
is: HMDB00302
initial concentration: 1.0
type: Species
boundary condition: false
name: UDP-D-galactose(2-)
is: CHEBI:58439
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM HC00250 c
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:29919

metaR RE1709N
modifier: MODEL1310110064#
product: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reactant: MODEL1310110064#
fast: false
type: Reaction
name: RE1709

metaR r1619
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
fast: false
is described by: ECO:0000000

metaR RE2541E
modifier: MODEL1310110064#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true
is: SBO:0000176
product: MODEL1310110064#
type: Reaction
name: RE2541
reactant: MODEL1310110064#

metaR r1587
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
is: SBO:0000185

metaR r0946
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
product: MODEL1310110064#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#

metaM dgtp e
name: dGTP
is: HMDB01440
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:16497
constant: false
type: Species

metaM 3ohdcoa m
type: Species
boundary condition: false
is: CHEBI:57349
has only substance units: false
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: HMDB06402
name: 3-oxopalmitoyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM 4ppcys c
has only substance units: false
is: CHEBI:59458
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: SBO:0000247
initial concentration: 1.0
is: C04352
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
constant: false
initial amount: NaN
is: HMDB01117

http://identifiers.org/biomodels.db/MODEL1310110064#_37097d1b_0205_4c31_8015_a6f41433b5c2
initial concentration: NaN
initial amount: NaN
is: Q9UN76
is encoded by: hsa:11254
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC6A14

http://identifiers.org/biomodels.db/MODEL1310110064#_65066370_6294_476f_86fe_09f951e0e0fb
is encoded by: hsa:219
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: ALDH1B1
has only substance units: false
is: P30837

metaM cspg b l
boundary condition: false
type: Species
is: C00318
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial concentration: 1.0
constant: false
is: HMDB00062
is: SBO:0000247
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial amount: NaN
is: CHEBI:16347

http://identifiers.org/biomodels.db/MODEL1310110064#_29bb0a1d_2f0c_4116_a1a2_445cb777601b
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _D29675_1_e
boundary condition: true
is encoded by: hsa:D29675

http://identifiers.org/biomodels.db/MODEL1310110064#_4a0ceb25_b3dc_4d55_b635_62fb39e73669
constant: false
is: Q96KJ9
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:84701
is: SBO:0000252
name: COX4I2

metaR URAt
is described by: ECO:0000269
fast: false
product: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110064#
name: uracil transport via facilated diffusion
is: SBO:0000185
reactant: MODEL1310110064#

metaR CREATt4 2 r
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: Creatine transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110064#
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110064#

metaM glu L m
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00148
name: L-glutamate(1-)
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:29985

metaM udpacgal g
is: HMDB00304
boundary condition: false
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_e6d21b09_a0cd_4b9c_ab1d_1cfe0d6636d4
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000297
constant: false

metaM HC02213 e
is: CHEBI:28031
type: Species
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-e3
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439

metaR r1618
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110064#

metaR ACOAD1fm
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110064#
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000269
product: MODEL1310110064#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is: SBO:0000176
reactant: MODEL1310110064#

metaR H2Otg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110064#
name: H2O transport, Golgi apparatus
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_6cf7a1a5_3a57_4e1a_96ac_cb971099c4bf
boundary condition: true
is encoded by: hsa:23657
has only substance units: false
is: Q9UPY5
initial concentration: NaN
name: SLC7A11
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaM 3mop m
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: SBO:0000247
is: HMDB00491
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaM pi n
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00973
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
name: hydrogenphosphate
initial concentration: 1.0

metaM udpgal e
name: UDP-D-galactose(2-)
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00302
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

metaR THD1m
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
fast: false
reactant: MODEL1310110064#
reversible: true
name: NAD(P) transhydrogenase
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.6.1.2
is described by: ECO:0000269
type: Reaction
product: MODEL1310110064#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_cfeedc74_838d_4c46_ade2_7ff77f1c136e
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:8781
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: _8781_1_c

http://identifiers.org/biomodels.db/MODEL1310110064#_4e5771b3_edea_45c9_9bb2_631e8677e1f2
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:29968
is: SBO:0000252
name: PSAT1
type: Species
constant: false
initial amount: NaN

metaR GLNtN1
product: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110064#
name: Glutamine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185

metaM 5thf l
name: pentaglutamyl folate (THF)
initial concentration: 1.0
boundary condition: false
is: CHEBI:3729
is: C00440
initial amount: NaN
type: Species
is: HMDB01396
is: SBO:0000247
constant: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d80dcf97_5fec_4a50_bb50_d27e66e4c455
is encoded by: hsa:122481
name: AK7
has only substance units: false
is: Q96M32
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaR ARAB Lt
is: SBO:0000185
is described by: ECO:0000000
name: L-arabinoase extracellular transport
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
product: MODEL1310110064#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110064#

metaM glu L l
boundary condition: false
initial concentration: 1.0
is: HMDB00148
constant: false
has only substance units: false
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
is: SBO:0000247
initial amount: NaN
type: Species

metaR 3MOPt2im
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_81120943_d7d9_4d82_8a52_0c74eb54d103
initial amount: NaN
constant: false
has only substance units: false
name: CROT
is: E7EQF2
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:54677
initial concentration: NaN

metaM dump n
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: CHEBI:246422
boundary condition: false
name: dUMP(2-)
is: HMDB01409

metaM HC00591 c
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
is: CHEBI:16769
is: SBO:0000247

metaR r1617
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000

metaR ACGPID
modifier: MODEL1310110064#
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.5.1.89
reactant: MODEL1310110064#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
type: Reaction
fast: false

metaM prostgd2 r
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
boundary condition: false
type: Species
is: CHEBI:57406
has only substance units: false
initial concentration: 1.0
constant: false
name: prostaglandin D2(1-)

http://identifiers.org/biomodels.db/MODEL1310110064#_efa37687_d032_4f32_9120_b2a2bf3f771e
constant: false
is: Q53H96
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:65263
boundary condition: true
initial concentration: NaN
name: PYCRL
initial amount: NaN

metaR r0688
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
product: MODEL1310110064#
type: Reaction
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176

metaM HC00250 e
has only substance units: false
name: hydrosulfide
type: Species
is: CHEBI:29919
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0

metaR FAOXC140
kinetic law: MODEL1310110064#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110064#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110064#
name: Beta oxidation of long chain fatty acid

metaM pi m
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00973
is: C00009
has only substance units: false
name: hydrogenphosphate

metaR GLYt2r
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110064#
product: MODEL1310110064#
name: glycine reversible transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110064#_aca163ca_c45f_4b5d_87ec_425a071c1082
initial concentration: NaN
has only substance units: false
name: NANS
is encoded by: hsa:54187
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: Q9NR45

metaR IDOAASE4ly
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#
fast: false
name: alpha-L-iduronidase, lysosomal
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76

metaR RE1796M
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is: SBO:0000176
product: MODEL1310110064#
reactant: MODEL1310110064#
name: RE1796

metaM 5thf m
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: C00440
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:3729
has only substance units: false
name: pentaglutamyl folate (THF)
is: HMDB01396

metaR PROSTGI2tr
product: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
is described by: ECO:0000269
name: Prostaglandin I2 transport (ER)
fast: false
type: Reaction
reactant: MODEL1310110064#

metaM asn L m
is: HMDB00168
initial concentration: 1.0
name: L-asparagine
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:17196

http://identifiers.org/biomodels.db/MODEL1310110064#_1e8758f2_6570_4116_aae7_3be61b0bf9bb
has only substance units: false
name: SLC5A9
is: SBO:0000252
is encoded by: hsa:200010
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: E9PAK4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_4a81c516_8696_4aa8_8708_063fc1772ed4
is: P43166
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: CA7
is encoded by: hsa:766

metaR 3HCO3 NAt
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
is: SBO:0000185
reversible: true
name: 3HCO3_NAt
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
is described by: ECO:0000134

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR r1616
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM hmgcoa m
type: Species
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
has only substance units: false
is: CHEBI:15467

http://identifiers.org/biomodels.db/MODEL1310110064#_49993335_1e16_4441_9877_bf2d4ab6ed81
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: SLC26A6
initial concentration: NaN
is encoded by: hsa:65010
boundary condition: true
is: SBO:0000252
is: Q9NQU1

metaM srtn e
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: HMDB00259
name: serotonin(1+)
boundary condition: false
constant: false
is: CHEBI:350546
type: Species
initial concentration: 1.0

metaM HC02213 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: CHEBI:28031
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-e3
constant: false
type: Species
boundary condition: false
has only substance units: false

metaM ps hs c
is: CHEBI:18303
constant: false
has only substance units: false
is: SBO:0000247
name: ps_hs[c]
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN

metaR ALR2
is: SBO:0000176
product: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110064#
name: aldose reductase (methylglyoxal)
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false

metaM udpgal g
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
is: SBO:0000247
name: UDP-D-galactose(2-)
is: HMDB00302
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58439

http://identifiers.org/biomodels.db/MODEL1310110064#_710c4343_04cc_4f9c_909d_f33171c26fb0
is: P19174
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: PLCG1
initial concentration: NaN
constant: false
is encoded by: hsa:5335

metaM m2gacpail hs r
is: CHEBI:16038
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
has only substance units: false
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN

metaR RE1523M
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
fast: false
modifier: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1523
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_86fb5362_b2bc_4d5b_90d1_ffb9feca25f1
constant: false
has part: P48728
boundary condition: true
initial concentration: NaN
is encoded by: hsa:275
has part: P23378
name: DLD:GCSH:GLDC:AMT
has only substance units: false
has part: P23434
initial amount: NaN
is encoded by: hsa:2731
type: Species
is encoded by: hsa:2653
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110064#_c7d383d0_2bc2_4629_91e3_2b5166e23eb4
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10449
has only substance units: false
is: P42765
name: ACAA2
type: Species

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM pyr m
name: pyruvate
is: HMDB00243
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:15361
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
has only substance units: false
is: C00022

metaR r1615
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR MMSAD3m
is described by: ECO:0000269
type: Reaction
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
modifier: MODEL1310110064#

metaM sphs1p r
is: SBO:0000247
type: Species
is: CHEBI:60119
initial concentration: 1.0
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
constant: false
boundary condition: false
has only substance units: false
name: sphingosine 1-phosphate(1-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_9256f6c3_2cea_45a6_a830_e5eafdec6c89
is: SBO:0000252
initial amount: NaN
constant: false
name: PANK4
is: Q9NVE7
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55229
type: Species

metaM leuktrC4 c
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial amount: NaN
is: HMDB01198
has only substance units: false
boundary condition: false
name: leukotriene C4(2-)
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57973
type: Species

metaM adp c
is: C00008
has only substance units: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3310
constant: false
name: ADP
is: HMDB01341
is: CHEBI:16761
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_5dc10678_e5e0_44d5_b3b2_2b47255ee6b4
type: Species
has only substance units: false
is: Q16853
initial amount: NaN
name: AOC3
constant: false
boundary condition: true
is encoded by: hsa:8639
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_028ac7a2_2b0b_4724_ac68_68affa08e2f4
type: Species
has only substance units: false
is encoded by: hsa:6575
name: SLC20A2
initial concentration: NaN
constant: false
initial amount: NaN
is: B2RBR4
is: SBO:0000252
boundary condition: true

metaR r1580
reversible: true
is: SBO:0000185
product: MODEL1310110064#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pi r
is: C00009
is: SBO:0000247
type: Species
is: HMDB00973
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:43474
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false

metaR r0578
modifier: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.2.27
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

metaM so4 m
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16189
name: sulfate
initial concentration: 1.0

metaM udpacgal c
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
is: SBO:0000247
is: HMDB00304

http://identifiers.org/biomodels.db/MODEL1310110064#_63db527b_6a37_4b56_ab96_a18c5eaf021d
boundary condition: true
initial amount: NaN
is: Q85KV6
constant: false
name: ND1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4535
type: Species

metaR r1614
product: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_2b33f735_fdad_4847_86d2_8e7a7ebdc9c9
initial amount: NaN
is encoded by: hsa:29922
type: Species
is: SBO:0000252
name: NME7
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaR NDPK5n
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
product: MODEL1310110064#
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_6e2d9816_ec95_486f_a0b2_981f593ecc92
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:9091
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: B2RAU6
name: PIGQ

http://identifiers.org/biomodels.db/MODEL1310110064#_ab3c764d_6b4f_4675_99d1_e27ca042d612
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4713
is: SBO:0000252
type: Species
name: NDUFB7
constant: false
is: P17568
initial amount: NaN

metaR r1581
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR RE1709C
name: RE1709
reversible: true
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM leuktrC4 e
is: HMDB01198
boundary condition: false
is: SBO:0000247
name: leukotriene C4(2-)
has only substance units: false
initial amount: NaN
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_2cee1414_d65c_4c77_994b_1678c0eca139
type: Species
has only substance units: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is: SBO:0000297
is encoded by: hsa:7991
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaR VALt5m
name: Valine reversible mitochondrial transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185
reversible: true

metaM hmgcoa c
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01375
has only substance units: false
constant: false
initial amount: NaN
name: Hydroxymethylglutaryl-CoA

metaM HC01118 r
has only substance units: false
is: CHEBI:57310
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
name: presqualene diphosphate(3-)

metaR r0339
is: SBO:0000176
modifier: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31

metaR r0579
reversible: true
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
fast: false
modifier: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.19
is described by: ECO:0000000

metaM udp n
initial amount: NaN
is: SBO:0000247
name: UDP(3-)
is: HMDB00295
type: Species
constant: false
has only substance units: false
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
initial concentration: 1.0

metaR r1613
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_74df0190_8e2d_46ef_b24a_97a97a08d3b0
type: Species
is encoded by: hsa:1327
name: COX4I1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: P13073
boundary condition: true
has only substance units: false

metaR GLYK
fast: false
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.30
name: glycerol kinase
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110064#
is: SBO:0000176

metaR DITPtn
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dITP nuclear transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f4a96eac_766f_4cde_b70e_429a1e852b23
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: AKR1A1
type: Species
is: SBO:0000252
is encoded by: hsa:10327

http://identifiers.org/biomodels.db/MODEL1310110064#_dad2f06f_7e86_4cee_8c39_b109a8693424
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: HSD17B10
has only substance units: false
is: Q99714
constant: false
type: Species
is encoded by: hsa:3028

metaM dopa c
is: CHEBI:59905
has only substance units: false
type: Species
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00073
is: SBO:0000247
name: dopaminium(1+)
boundary condition: false

metaM HC01434 m
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
is: CHEBI:58931
name: oxalatosuccinate(3-)
type: Species
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN

metaM 3ump e
initial amount: NaN
name: 3'-UMP(2-)
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 EHMN_ABBREVIATION: C01368
constant: false
is: CHEBI:60784
initial concentration: 1.0
boundary condition: false

metaM cspg b e
has only substance units: false
is: CHEBI:17568
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial amount: NaN
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
type: Species
is: HMDB00300
boundary condition: false
initial concentration: 1.0
constant: false
is: C00106

metaR THFtl
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
reversible: true
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, lysosomal
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_02d10e92_9bb3_43c2_a6a0_59b0aab92a60
name: PIGH
is: Q14442
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5283
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR PMTCOAtx
reactant: MODEL1310110064#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is: SBO:0000185
product: MODEL1310110064#
name: fatty acid intracellular transport
kinetic law: MODEL1310110064#

metaR PItx
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
name: Phosphate transporter, peroxisome
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_3b870db3_4ee9_4e7e_b7b4_9f1460109d61
has only substance units: false
is: Q9Y6M9
is encoded by: hsa:4715
initial concentration: NaN
is: SBO:0000252
type: Species
name: NDUFB9
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d2768c47_efd0_4b0e_875c_56050f25b292
name: ACADM
is: P11310
is encoded by: hsa:34
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_5efda6c4_50a3_415a_a543_13c35a27e8f3
has only substance units: false
has part: Q99519
boundary condition: true
name: GALNS:GLB1:NEU1:CTSA
constant: false
has part: P10619
is: SBO:0000297
is encoded by: hsa:2720
has part: P16278
type: Species
has part: P34059
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2588
is encoded by: hsa:5476
is encoded by: hsa:4758

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_4ce61a0b_93a0_434d_bd8b_b3ff366d3106
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:18
type: Species
constant: false
name: ABAT
has only substance units: false
boundary condition: true

metaR r1612
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR RE1534M
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: RE1534

metaR THFtm
product: MODEL1310110064#
fast: false
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110064#_9c874254_fc36_4a94_a83c_deca916cd377
name: PLA2G2A
is encoded by: hsa:5320
constant: false
is: P14555
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_51d38dec_2250_4339_96f5_9c797825a400
type: Species
has only substance units: false
is: P48651
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9791
name: PTDSS1
is: SBO:0000252
initial amount: NaN
constant: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR GLXO1
product: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.2.4
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
modifier: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110064#
name: glyoxylate oxidase

http://identifiers.org/biomodels.db/MODEL1310110064#_419beae3_1a73_41af_8000_e0604a8cefe2
has only substance units: false
name: NNT
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23530
is: Q13423
boundary condition: true

metaR FPGS3m
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: folylpolyglutamate synthetase, mitochondrial
is version of: http://identifiers.org/ec-code/6.3.2.17
reversible: false
is: SBO:0000176
modifier: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_ad81b84c_82a3_474a_b65a_030560108b9c
boundary condition: true
is: O76062
constant: false
name: TM7SF2
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7108
initial concentration: NaN

metaM HC01408 m
type: Species
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
is: CHEBI:27648
has only substance units: false
initial amount: NaN
name: 3-Oxohexanoyl-CoA
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d31f8862_7661_4e31_ae44_a125939595b2
name: _AA614647_1_c
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA614647
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaM nadp c
is: CHEBI:58349
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: C00006
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
constant: false

metaM udp l
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00295
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:58223

metaM so4 l
is: HMDB01448
constant: false
is: CHEBI:16189
initial concentration: 1.0
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
type: Species
is: SBO:0000247
name: sulfate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_9ba20344_0d3a_4cbf_adce_5a9e24fae873
name: DGKZ
initial concentration: NaN
boundary condition: true
constant: false
is: B7Z2M9
has only substance units: false
is encoded by: hsa:8525
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_88ae016e_f89c_43b8_9df2_5885888825fc
initial concentration: NaN
has only substance units: false
name: CMAS
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55907
boundary condition: true
is: Q8NFW8
type: Species
constant: false

metaM leuktrA4 c
has only substance units: false
type: Species
is: HMDB01337
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
constant: false
name: leukotriene A4(1-)
boundary condition: false
is: CHEBI:57463
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_db37ba00_dac3_414f_89bf_309d651fe8c3
has only substance units: false
boundary condition: true
is encoded by: hsa:221823
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: PRPS1L1
initial concentration: NaN
is: P21108

http://identifiers.org/biomodels.db/MODEL1310110064#_98045446_afa5_4105_880c_f1649784c23b
type: Species
boundary condition: true
name: PLA2G2E
is encoded by: hsa:30814
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9NZK7
is: SBO:0000252
constant: false

metaM mi4p D c
name: 1D-myo-inositol 4-phosphate(2-)
initial amount: NaN
initial concentration: 1.0
is: HMDB01313
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58469
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
type: Species
constant: false

metaR r1611
is described by: ECO:0000000
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_30561fc5_21c1_4d85_a8d9_ce2595adef61
name: LDHA
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: P00338
is encoded by: hsa:3939
initial amount: NaN
constant: false

metaM HC02204 c
name: prostaglandin-b1
constant: false
type: Species
is: CHEBI:27624
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_791102f9_ddd0_42a5_8827_83b8d9c1058e
is: Q99884
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: SLC6A7
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6534

metaR LNLNCGt
reversible: true
product: MODEL1310110064#
name: fatty acid transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
fast: false

metaR DIDPtn
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
reversible: true
name: dIDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_391fc4ba_d366_47e5_bda4_83a16a0e341d
name: _AI935189_1_m
is encoded by: hsa:AI935189
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaM f1a l
has only substance units: false
type: Species
is: HMDB02917
constant: false
is: CHEBI:17151
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: F1alpha
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_cd574281_9611_4dfb_a0af_a6a5459d6d84
initial concentration: NaN
is encoded by: hsa:5169
has only substance units: false
is: Q308M7
initial amount: NaN
boundary condition: true
type: Species
name: ENPP3
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_cc6f5fc3_c8d7_4789_8050_cb71dbbbcc35
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: CHAT
initial amount: NaN
type: Species
is encoded by: hsa:1103
is: D3DX95

metaM dopa e
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
is: SBO:0000247
has only substance units: false
name: dopaminium(1+)
boundary condition: false
is: HMDB00073
is: CHEBI:59905

metaM ppp9 m
constant: false
is: CHEBI:36159
has only substance units: false
name: Protoporphyrin
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00241
initial concentration: 1.0
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191

metaR r1584
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_267b97a3_91ef_41f6_ac3a_6ccc14323568
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: B4E3E9
initial amount: NaN
initial concentration: NaN
constant: false
name: OGDH
is encoded by: hsa:4967

metaR r2120
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR ARGLYSex
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
name: Arginine/Lysine exchanger (Arg in)
modifier: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110064#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_97988a1b_eb27_4958_bec4_f7670beb9aa9
has only substance units: false
initial amount: NaN
is: Q9P0Z9
constant: false
name: PIPOX
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:51268

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR VALTA
is version of: http://identifiers.org/ec-code/2.6.1.42
name: valine transaminase
fast: false
is: SBO:0000176
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction

metaR r1610
reversible: true
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110064#

metaM adp n
name: ADP(3-)
is: HMDB01341
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:456216
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaR HAS2
fast: false
is described by: ECO:0000269
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase
product: MODEL1310110064#
reactant: MODEL1310110064#

metaM dgdp m
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00960
name: dGDP(2-)
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58595

http://identifiers.org/biomodels.db/MODEL1310110064#_b50b5ddc_c777_4c42_bb9c_ecc5b35148d1
name: _AI697028_1_e
initial concentration: NaN
is encoded by: hsa:AI697028
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM thr L e
is: HMDB00167
name: L-threonine
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16857
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_a398b1c7_e670_4ce1_a887_735b91acb622
has only substance units: false
type: Species
is encoded by: hsa:4723
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: E5KNH5
initial concentration: NaN
name: NDUFV1

metaM asn L e
has only substance units: false
type: Species
boundary condition: false
is: HMDB00168
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17196
constant: false
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine

http://identifiers.org/biomodels.db/MODEL1310110064#_095dbf09_55da_49e5_8d25_72015fc88736
name: RBAK
is: Q9NYW8
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:57786

http://identifiers.org/biomodels.db/MODEL1310110064#_3da72a07_81f2_44f8_9937_d6d9adbab506
boundary condition: true
is encoded by: hsa:2348
initial amount: NaN
type: Species
name: FOLR1
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR RBTt
product: MODEL1310110064#
fast: false
type: Reaction
reactant: MODEL1310110064#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: ribitol transport via passive diffusion

http://identifiers.org/biomodels.db/MODEL1310110064#_4bbc8014_ccb5_49ea_9414_412fd5c2fbb1
initial concentration: NaN
is encoded by: hsa:54407
initial amount: NaN
is: Q96QD8
has only substance units: false
name: SLC38A2
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM HC00900 c
initial concentration: 1.0
has only substance units: false
name: Methylmalonate
constant: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:30860

metaR r2121
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110064#
reversible: true
is described by: ECO:0000000

metaM adp m
is: HMDB01341
is: SBO:0000247
initial amount: NaN
is: C00008
is: CHEBI:456216
constant: false
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/3310
type: Species
boundary condition: false
name: ADP

metaR ECOAH9m
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000304
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
reversible: true
fast: false

metaR r0129
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110064#
type: Reaction
fast: false
reversible: true
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_755e7ba1_564d_4f9f_a942_499fd0b5335d
initial concentration: NaN
name: _U37519_1_c
is encoded by: hsa:U37519
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_1c0210cc_e7dc_4bf9_bbd8_198c16bbf9f3
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:AL048840
is: SBO:0000252
name: _AL048840_1_c
type: Species

metaR r1585
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
product: MODEL1310110064#

metaR HMBS
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.5.1.61
modifier: MODEL1310110064#
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
name: hydroxymethylbilane synthase

metaR r0714
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_f92a79ba_3269_40ed_81cc_66c54437c727
is: SBO:0000252
constant: false
is: O76062
boundary condition: true
is encoded by: hsa:7108
type: Species
name: TM7SF2
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_40470e67_e80b_4df8_b391_497160eb3d82
boundary condition: true
name: SLC13A4
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:26266
is: SBO:0000252
is: Q9UKG4

metaM pyr c
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:15361
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
name: pyruvate
is: C00022
boundary condition: false
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1
is: HMDB00243

metaR TXASr
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
is described by: ECO:0000134
reactant: MODEL1310110064#
name: Thromboxane-A synthase
reversible: false
kinetic law: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.5
type: Reaction

metaM 5thf e
has only substance units: false
is: SBO:0000247
is: HMDB06487
initial amount: NaN
notes: FORMULA: C39H45N11O18 CHARGE: -6
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: pentaglutamyl folate (THF)

metaM udp r
is: C00015
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
name: UDP
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58223
has only substance units: false
initial amount: NaN
boundary condition: false

metaM 5mthf c
type: Species
is: CHEBI:3729
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00440
is: HMDB01396
name: 5-Methyltetrahydrofolate
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_748e6f18_3e6a_493e_9fca_b1c3b95fc691
is: Q9NY65
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1962
initial amount: NaN
type: Species
initial concentration: NaN
name: EHHADH
constant: false
boundary condition: true

metaM acnam n
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
initial concentration: 1.0
boundary condition: false
name: N-acetylneuraminate
type: Species
constant: false
is: CHEBI:35418
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR RE1897C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: RE1897
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
type: Reaction
fast: false
is: SBO:0000176

metaM dgdp n
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: HMDB00960
boundary condition: false
is: CHEBI:58595
name: dGDP(2-)
has only substance units: false
initial amount: NaN

metaM pa hs m
has only substance units: false
is: CHEBI:57739
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
initial concentration: 1.0
boundary condition: false

metaR ADA
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
reactant: MODEL1310110064#
name: Adenosine deaminase
modifier: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4

metaR FATP3t
fast: false
name: fatty acid electroneutral transport
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000185
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
modifier: MODEL1310110064#
is described by: ECO:0000269

metaR SUCD1m
is version of: http://identifiers.org/ec-code/1.3.5.1
name: succinate dehydrogenase
is described by: ECO:0000134
reversible: true
product: MODEL1310110064#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false

metaR ECOAH1m
is described by: ECO:0000304
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
is: SBO:0000176
modifier: MODEL1310110064#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
fast: false
reversible: true
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110064#_cfc1da6b_dbda_455e_a307_77186746cd79
name: COX6B1
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1340
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P14854
has only substance units: false

metaR HYXNt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
product: MODEL1310110064#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110064#
name: Hypoxanthine transport
reversible: true
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
type: Reaction

metaR 2AMADPTm
is: SBO:0000185
reversible: true
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
fast: false
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is described by: ECO:0000269
kinetic law: MODEL1310110064#

metaR G6PDA
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.99.6
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
name: glucosamine-6-phosphate deaminase
is: SBO:0000176
modifier: MODEL1310110064#
fast: false
reversible: false
reactant: MODEL1310110064#
type: Reaction

metaM pi x
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: CHEBI:43474
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00973
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_d85a617a_918d_428d_83b5_344d3eb7bc73
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: F5GY65
initial concentration: NaN
type: Species
is encoded by: hsa:8402
name: SLC25A11

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR RNDR1
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110064#
is described by: ECO:0000254
is: SBO:0000176
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
reversible: false
name: ribonucleoside-diphosphate reductase (ADP)
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:

metaR CHOLtn
is: SBO:0000185
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
product: MODEL1310110064#
type: Reaction
name: Choline transport, nuclear through pores
is described by: ECO:0000000
kinetic law: MODEL1310110064#
fast: false
reversible: true

metaM asn L c
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00168
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
has only substance units: false
is: CHEBI:17196

http://identifiers.org/biomodels.db/MODEL1310110064#_73be10d5_5a5d_4f31_88af_1dd10d95de2e
constant: false
is: E9PD84
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PCYT1B
type: Species
boundary condition: true
is encoded by: hsa:9468

http://identifiers.org/biomodels.db/MODEL1310110064#_bf20a659_2132_4d38_a7cb_def2a8b2c46d
is encoded by: hsa:4842
is: B4DG68
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: NOS1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d08da674_ad23_4a12_b6c2_534c03702f71
name: SDHA:SDHB:SDHC:SDHD
type: Species
is: SBO:0000297
is encoded by: hsa:6389
has part: Q99643
has only substance units: false
has part: P31040
initial amount: NaN
is encoded by: hsa:6391
is encoded by: hsa:6390
is encoded by: hsa:6392
has part: O14521
has part: P21912
boundary condition: true
initial concentration: NaN
constant: false

metaR r1583
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_04ad6bd4_2ea0_4c7e_b30c_e38db313d723
is encoded by: hsa:AI480132
boundary condition: true
constant: false
name: _AI480132_1_c
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_b2121697_a14d_46ff_8a89_5b6ad9f16b6f
constant: false
has only substance units: false
is: P54819
is: SBO:0000252
is encoded by: hsa:204
initial concentration: NaN
type: Species
name: AK2
boundary condition: true
initial amount: NaN

metaM pyr e
constant: false
is: CHEBI:15361
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: pyruvate
is: HMDB00243
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_070ce4c2_b9e2_4c16_aae9_90931e3189e7
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:223
has only substance units: false
name: ALDH9A1
type: Species
is: P49189
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_a41fa2f9_2d46_4bab_b228_c23280d908b6
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: XDH
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:7498
is: P47989

metaR UDPtl
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
name: udp intracellular transport
fast: false
kinetic law: MODEL1310110064#

metaR RNDR2
type: Reaction
reactant: MODEL1310110064#
is described by: ECO:0000254
name: ribonucleoside-diphosphate reductase (GDP)
fast: false
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176

metaR FERO
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110064#
is described by: ECO:0000134
name: ferroxidase
modifier: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_db051ef8_34b4_46f5_a229_b840ee2ada37
initial concentration: NaN
has only substance units: false
type: Species
is: Q02218
name: OGDH
is: SBO:0000252
is encoded by: hsa:4967
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_9cdd3d8e_dc7f_4c63_aeb7_694719af3067
is: SBO:0000252
name: SLC4A3
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6508
initial amount: NaN

MODEL1310110064
reaction: metaR NAGA2ly
reaction: metaR RE1531M
reaction: metaR URATEt
reaction: metaR FAOXC200180m
species: metaM arach e
reaction: metaR CYTK6
reaction: metaR r0504
species: metaM oxa c
species: metaM acgal c
species: metaM 20ahchsterol m
species: metaM 4hpro LT m
reaction: metaR r2519
reaction: metaR MI4PP
reaction: metaR r2367
reaction: metaR r0575
reaction: metaR 4MOPte
reaction: metaR PGMT
species: metaM nrpphr c
reaction: metaR DHCR72r
reaction: metaR r0547
reaction: metaR NACHEXA4ly
species: metaM pep c
reaction: metaR H2Otn
reaction: metaR EX citr L LPAREN e RPAREN
reaction: metaR XANDp
reaction: metaR GAPD
species: metaM glyc R m
reaction: metaR GLYOX
reaction: metaR r0989
reaction: metaR RE1520M
species: metaM 4ppcys m
species: metaM 7thf c
species: metaM dhcholestanate c
species: metaM 5adtststerone c
reaction: metaR r1565
reaction: metaR r1664
reaction: metaR r2409
reaction: metaR r0062
species: metaM glutcoa m
reaction: metaR PIPLC
reaction: metaR r2081
reaction: metaR r0033
reaction: metaR r1606
reaction: metaR EX HC00250 LPAREN e RPAREN
reaction: metaR r0993
species: metaM 3hmbcoa m
species: metaM biliverd c
reaction: metaR EX q10h2 LPAREN e RPAREN
reaction: metaR RE2677E
species: metaM dgdp n
reaction: metaR DLNLCGt
species: metaM nadh x
species: metaM gtp m
species: metaM o2 n
species: metaM hdca l
species: metaM aacoa x
reaction: metaR SBT Dtde
reaction: metaR r1455
reaction: metaR DNADtn
species: metaM glx x
species: metaM L2aadp m
species: metaM lnlncg r
species: metaM f6p c
species: metaM HC01376 m
reaction: metaR 3HKYNAKGAT
species: metaM dgdp c
reaction: metaR r1427
reaction: metaR PPDOy
reaction: metaR ADNt
reaction: metaR r0408
species: metaM trp L e
reaction: metaR RE0453C
species: metaM leuktrF4 c
species: metaM xol25oh r
species: metaM C02528 e
reaction: metaR IDOURtly
reaction: metaR HAS2
reaction: metaR EX cyan LPAREN e RPAREN
reaction: metaR r0470
reaction: metaR LTD4DP

metaM msa m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
name: 3-oxopropanoate
constant: false
is: HMDB11111
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:33190

metaM f1a g
is: CHEBI:17151
has only substance units: false
initial concentration: 1.0
is: HMDB02917
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: F1alpha
constant: false

metaR GGT6
reactant: MODEL1310110064#
is described by: ECO:0000000
name: Gamma-glutamyltransferase
kinetic law: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
fast: false
reversible: true
type: Reaction

metaR r1660
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
fast: false

metaR GCC2bim
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#

metaM chlstol r
has only substance units: false
is: HMDB06842
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16290
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_ee21f736_011f_4c53_a390_da9078195f9a
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5464
type: Species
initial concentration: NaN
name: PPA1
initial amount: NaN
is: Q15181

metaR UMPK3
name: UMP kinase (UTP)
kinetic law: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_2422b218_6f72_48a9_8469_823ddbda19f7
is: O60760
initial amount: NaN
is encoded by: hsa:27306
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: HPGDS

metaM prostgf2 e
boundary condition: false
initial amount: NaN
name: prostaglandin F2alpha(1-)
is: CHEBI:57404
has only substance units: false
is: HMDB01139
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247

metaM glc D e
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:4167
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
name: D-glucose

metaM dtdp n
has only substance units: false
is: CHEBI:58369
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR r0553
kinetic law: MODEL1310110064#
reversible: true
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176

metaR r0970
fast: false
is described by: ECO:0000000
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
type: Reaction
product: MODEL1310110064#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_f4e4e4d6_bdb1_4388_8baa_d22e460b247c
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: _BF195998_1_x
is encoded by: hsa:BF195998

metaM citr L e
constant: false
name: citr_L[e]
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00904
has only substance units: false
is: CHEBI:16349
initial amount: NaN
is: SBO:0000247

metaM pmtcoa c
type: Species
is: C00154
has only substance units: false
is: HMDB01338
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
boundary condition: false
is: CHEBI:3454
constant: false
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
initial amount: NaN

metaM chol m
has only substance units: false
constant: false
is: HMDB00097
boundary condition: false
type: Species
is: CHEBI:15354
initial amount: NaN
name: choline
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaM 4abutn c
is: HMDB01080
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:58264
name: 4-Aminobutanal
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
is: C00555

http://identifiers.org/biomodels.db/MODEL1310110064#_35d118a3_f4b9_41ed_acf0_92ff07bc7944
initial concentration: NaN
initial amount: NaN
name: NDUFB3
boundary condition: true
is encoded by: hsa:4709
is: Q6IB80
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR r2139
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#

metaM pail5p hs n
is: CHEBI:57795
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR NAGA2ly
reversible: false
is: SBO:0000176
modifier: MODEL1310110064#
name: N-acetylgalactosaminidase, alpha-
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.49

http://identifiers.org/biomodels.db/MODEL1310110064#_f00e89ac_8c5e_4a30_8025_2d9eac66f53a
is: D9HTE9
is encoded by: hsa:6576
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: SLC25A1
initial concentration: NaN
is: SBO:0000252

metaR UMPK2
product: MODEL1310110064#
modifier: MODEL1310110064#
name: UMP kinase (CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110064#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110064#_57ed6a43_5f0a_4c19_9bd9_a90c304b9744
name: _BE966236_1_m
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:BE966236
boundary condition: true
is: SBO:0000252

metaM k c
initial amount: NaN
name: potassium
is: HMDB00586
is: C00238
initial concentration: 1.0
is: CHEBI:29103
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238

metaR S4TASE3ly
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false

metaM dtdp m
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01274
type: Species
boundary condition: false
is: CHEBI:58369
name: dTDP
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: C00363

metaR RE2079R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
fast: false
reversible: true
is described by: ECO:0000000
name: RE2079
is: SBO:0000176

metaM dnad n
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 INCHI: InChI=1S/C21H26N6O15P2/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H4-,22,23,24,32,33,34,35,36,37)/p+1/t10-,11-,13-,14-,15-,16-,19-,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: HMDB01179
initial amount: NaN
boundary condition: false
name: Deamino-NAD+
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:18304
type: Species
constant: false

metaM dhcholestanate c
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
is: CHEBI:16577
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaR r0552
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110064#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_0fca1d90_6435_4c54_842e_1a11eb72678e
constant: false
is encoded by: hsa:6392
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O14521
has only substance units: false
name: SDHD

metaM cdp c
is: CHEBI:58069
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: CDP
is: C00112
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
type: Species
is: HMDB01546

http://identifiers.org/biomodels.db/MODEL1310110064#_e15c6bb5_4efa_401d_8d91_8917baa70434
initial amount: NaN
boundary condition: true
name: NDUFC2
type: Species
is encoded by: hsa:4718
is: Q549M5
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_d8719926_c582_4206_bd7c_a4c3ad1102b6
is: Q99798
constant: false
name: ACO2
boundary condition: true
has only substance units: false
is encoded by: hsa:50
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_56650893_ffa8_4cf3_a9e0_079ea4bfb431
is: P36969
name: GPX4
is encoded by: hsa:2879
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM sbt D c
is: HMDB00247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
type: Species
initial amount: NaN
name: D-glucitol
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:17924
has only substance units: false
is: SBO:0000247

metaR ACt2m
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
name: acetate mitochondrial transport via proton symport
kinetic law: MODEL1310110064#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR HSD3A1r
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000269
reversible: true
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
is: SBO:0000176
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ

metaM g6p c
is: CHEBI:61548
is: HMDB01401
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00092
type: Species

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR DOLPMT4 Uer
product: MODEL1310110064#
is described by: ECO:0000000
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
fast: false
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_5d59cc38_8018_4d98_a005_7ba35273d9c9
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8879
name: SGPL1
is: O95470
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_510da0a5_50ab_4c98_bc9a_1a257f7ece29
constant: false
has only substance units: false
initial concentration: NaN
name: NT5C
is: Q8TCD5
is encoded by: hsa:30833
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaR UMPK5
modifier: MODEL1310110064#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110064#
name: UMP kinase (dATP)
product: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR 3HBCOAHLm
is described by: ECO:0000000
is: SBO:0000176
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reversible: false
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_a0c1878e_a209_40f3_96a6_1675f2004c87
is: P35790
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: CHKA
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1119
constant: false

metaR INSt
reversible: true
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
modifier: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
name: Inosine transport (diffusion)
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110064#_be712269_2e2e_47de_991e_c02e613963c3
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:28231
name: SLCO4A1
initial concentration: NaN
initial amount: NaN
is: Q96BD0
constant: false
type: Species

metaR DM 1a25dhvitd3 LPAREN n RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: G.F.M. Ball (2006) Vitamins their role in the human body, Blackwell publishing, chapter 8, page 198-199. NOTES:the 1,25-dihydroxy vitamin D3 binds to the vitamin D binding protein, migrates to the nucleus and accelerates genomic actions.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for vitD3
type: Reaction

metaR KYNATESYN
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000
reactant: MODEL1310110064#
product: MODEL1310110064#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110064#

metaR UMPK6
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110064#
type: Reaction
reversible: true
is described by: ECO:0000269
name: UMP kinase (dCTP)
modifier: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_2b299666_df8d_42b7_a342_5ec38c8f18af
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: CAD
is encoded by: hsa:790
type: Species
initial concentration: NaN
is: SBO:0000252
is: P27708

metaR r0407
reactant: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is: SBO:0000176
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13

http://identifiers.org/biomodels.db/MODEL1310110064#_ab370099_e45e_420f_85a5_476c8487987b
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q99999
constant: false
boundary condition: true
type: Species
is encoded by: hsa:9514
name: GAL3ST1
is: SBO:0000252

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM citr L c
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16349
is: HMDB00904
is: SBO:0000247
name: L-citrulline
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false

metaR NCKt
modifier: MODEL1310110064#
type: Reaction
reversible: true
name: Na+/Ca2+-K+ exchange
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110064#
is described by: ECO:0000269

metaM leuktrA4 e
type: Species
initial concentration: 1.0
is: CHEBI:57463
name: leukotriene A4(1-)
is: SBO:0000247
initial amount: NaN
is: HMDB01337
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_ebadf67b_3f9e_4454_b61c_877bee94064e
type: Species
is: P10746
boundary condition: true
is encoded by: hsa:7390
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: UROS
is: SBO:0000252

metaR r1662
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR r1661
fast: false
reversible: true
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110064#_121aaaa3_aa99_4abf_bdb0_71189701b7b1
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: SLC5A11
is: Q8WWX8
initial amount: NaN
is encoded by: hsa:115584

http://identifiers.org/biomodels.db/MODEL1310110064#_37431c3e_9009_4b57_9fb6_df0ecd2a7a21
name: _T83654_1_m
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:T83654
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_dbfaf969_2869_4ddc_8b53_98d580ed4e6c
boundary condition: true
is: Q92643
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:10026
name: PIGK
has only substance units: false

metaR r1650
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction

metaR GLYSNAT5tc
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR LTC4CP
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
name: Leukotriene C4 carboxypeptidase

metaR UMPK4
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
name: UMP kinase (GTP)
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_9ebd3fb5_4df1_4418_b82d_829aa4a3f5a8
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4731
name: NDUFV3

http://identifiers.org/biomodels.db/MODEL1310110064#_56190e94_3019_4334_a8e5_0942581aa2bf
constant: false
name: PPCS
initial amount: NaN
type: Species
is: Q9HAB8
boundary condition: true
has only substance units: false
is encoded by: hsa:79717
is: SBO:0000252
initial concentration: NaN

metaR r0408
product: MODEL1310110064#
reversible: true
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
reactant: MODEL1310110064#
is: SBO:0000176
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#

metaR r0973
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110064#
name: Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110064#_6eaedc45_b09b_4978_b551_4942c4825b58
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: _AI469183_1_x
is encoded by: hsa:AI469183
boundary condition: true
type: Species
has only substance units: false

metaM chol n
initial concentration: 1.0
is: HMDB00097
type: Species
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
boundary condition: false
is: CHEBI:15354
name: choline
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d9e5f780_f5b3_4b43_880e_9902cfd88be8
has only substance units: false
constant: false
type: Species
is encoded by: hsa:23169
boundary condition: true
name: SLC35D1
is: Q9NTN3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_bfa9d6de_ae7e_4e8f_9530_b44041bde5c0
boundary condition: true
name: NDUFA9
is encoded by: hsa:4704
initial amount: NaN
is: Q16795
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_d268d45d_13e5_465b_bc93_676146f87523
type: Species
name: NDUFB6
constant: false
is: SBO:0000252
boundary condition: true
is: Q5VYT2
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4712

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR SPH1Pte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
name: sph1p transport

metaR DURIt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
name: deoxyuridine transport via diffusion
product: MODEL1310110064#

metaM sarcs m
type: Species
boundary condition: false
name: Sarcosine
initial concentration: 1.0
is: C00213
constant: false
is: CHEBI:15611
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
initial amount: NaN
is: HMDB00271

metaR r1664
is: SBO:0000185
product: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#

metaR LPCOXp
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.3.1
reversible: false
name: L-pipecolate oxidase, peroxisomal
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176

metaM atp c
is: CHEBI:30616
initial amount: NaN
is: HMDB00538
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: C00002
is: SBO:0000247
type: Species
name: ATP(4-)

metaR RE1845C
name: RE1845
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR r1651
type: Reaction
product: MODEL1310110064#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110064#
reactant: MODEL1310110064#

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR ARACHCRNt
reactant: MODEL1310110064#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
name: transport into the mitochondria (carnitine)
reversible: false

metaM ctp c
boundary condition: false
is: C00063
name: CTP
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00082
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
is: CHEBI:37563
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_0ecf9821_a76f_4bcc_bdbb_771e616499d2
name: ESD
is: P10768
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:2098
initial amount: NaN

metaM cspg a l
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: C00318
has only substance units: false
is: CHEBI:16347
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
boundary condition: false
is: HMDB00062

metaM 3hmbcoa m
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: CHEBI:57312
is: HMDB01356

metaM pristcoa x
has only substance units: false
is: CHEBI:51341
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial concentration: 1.0
type: Species
is: SBO:0000247
name: pristanoyl coa
initial amount: NaN
constant: false
boundary condition: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR SARDHm
product: MODEL1310110064#
name: Sarcosine dehydrogenase (m)
is described by: ECO:0000269
reactant: MODEL1310110064#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.5.99.1

http://identifiers.org/biomodels.db/MODEL1310110064#_7ff3505c_89be_43f3_be40_52ebbac28341
is: Q7KZA3
is encoded by: hsa:2235
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: FECH

http://identifiers.org/biomodels.db/MODEL1310110064#_c034f974_17a9_41cc_aad0_bdd40d182f41
name: BAAT
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q14032
initial amount: NaN
is encoded by: hsa:570
type: Species
constant: false

metaM txa2 c
boundary condition: false
is: HMDB01452
type: Species
is: CHEBI:57445
initial concentration: 1.0
has only substance units: false
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial amount: NaN
is: SBO:0000247
constant: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM asp L c
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00191
is: CHEBI:29991
has only substance units: false
is: SBO:0000247
boundary condition: false
name: L-aspartate(1-)

metaR r1652
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_31812a07_47e1_4e31_92db_8f3011ccd789
is: SBO:0000252
is encoded by: hsa:84890
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: ADO
initial amount: NaN
is: B3KXN9
constant: false

metaM 3php c
is: HMDB01024
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 3-phosphonatooxypyruvate(3-)
is: CHEBI:18110

metaM gthrd m
initial concentration: 1.0
is: HMDB00125
is: SBO:0000247
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57925
name: glutathionate(1-)

http://identifiers.org/biomodels.db/MODEL1310110064#_fbbc950e_758d_4ee8_bcef_e45061943606
is encoded by: hsa:29920
is: SBO:0000252
is: Q96C36
has only substance units: false
constant: false
type: Species
boundary condition: true
name: PYCR2
initial concentration: NaN
initial amount: NaN

metaR UMPK7
name: UMP kinase (dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110064#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110064#_e16d649b_0ec7_4427_9d93_ef826990e2d8
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1633
is: P27707
initial amount: NaN
name: DCK
constant: false
type: Species
is: SBO:0000252

metaR PCm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.1
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
reversible: false
modifier: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
name: pyruvate carboxylase

metaR CHAT
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is version of: http://identifiers.org/ec-code/2.3.1.6
type: Reaction
is: SBO:0000176
name: Choline O-acetyltransferase
reversible: true
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_373228a2_d7f3_4b97_9da5_834b6a3cfb7e
constant: false
is: P19440
type: Species
is encoded by: hsa:2678
is: SBO:0000252
name: GGT1
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_669f68ea_a58b_4489_a25d_5ff29e15a85e
is: Q9H999
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: PANK3
is encoded by: hsa:79646
has only substance units: false
initial concentration: NaN
type: Species

metaM txa2 e
type: Species
initial concentration: 1.0
name: thromboxane A2(1-)
is: HMDB01452
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57445
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198

metaR r1653
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185

metaR ACt2r
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
reactant: MODEL1310110064#
name: acetate reversible transport via proton symport

metaR r1666
reactant: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000185

metaM ppi n
is: SBO:0000247
name: diphosphate(3-)
constant: false
is: CHEBI:33019
type: Species
is: HMDB00250
initial concentration: 1.0
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_8dc3d426_3be2_4770_95d6_194d25fe56d0
boundary condition: true
is encoded by: hsa:2712
is: SBO:0000252
initial amount: NaN
is: Q14410
has only substance units: false
constant: false
name: GK2
initial concentration: NaN
type: Species

metaM atp e
is: HMDB00538
name: ATP(4-)
constant: false
initial concentration: 1.0
is: CHEBI:57299
is: SBO:0000247
is: C00002
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaR r0355
kinetic law: MODEL1310110064#
fast: false
reversible: false
product: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is version of: http://identifiers.org/ec-code/4.2.1.3

metaR r2137
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is: SBO:0000185

metaR r2069
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
reversible: false
fast: false
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#

metaM so3 m
has only substance units: false
is: CHEBI:17137
type: Species
is: HMDB00240
constant: false
name: hydrogensulfite
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094

metaM prostgf2 c
name: prostaglandin F2alpha(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:57404
is: SBO:0000247
constant: false
is: HMDB01139
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f007fb87_27ba_4167_a251_a26db21c57b0
boundary condition: true
name: ALG12
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:79087
is: SBO:0000252
is: Q9BV10
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_8655c797_3ea4_4bf8_b731_a510208d0c19
is encoded by: hsa:80025
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: Q6P1K9
has only substance units: false
name: PANK2
boundary condition: true

metaR RE3566C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
fast: false
reversible: true
name: RE3566
reactant: MODEL1310110064#
type: Reaction

metaR FATP2t
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
name: fatty acid electroneutral transport
is described by: ECO:0000269
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_37b140dd_c698_421b_8f7e_3a89efa76975
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:19
is: O95477
boundary condition: true
name: ABCA1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_6b1f29df_010b_43ce_ac76_b27a64b944b2
name: ND5
initial concentration: NaN
is: P03915
is: SBO:0000252
is encoded by: hsa:4540
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM ppi m
has only substance units: false
type: Species
is: HMDB00250
is: CHEBI:33019
is: C00013
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate

metaR SUCOASm
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110064#
modifier: MODEL1310110064#
name: Succinate--CoA ligase (ADP-forming)
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
kinetic law: MODEL1310110064#
fast: false

metaR S6TASE9ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_79f371b6_6b45_46e4_b1ba_9406c6224ab5
name: NDUFA6
is encoded by: hsa:4700
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: P56556
initial amount: NaN

metaR r1654
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

metaR TRPt
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
name: L-tryptophan transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_4057278e_357c_4b3a_afa7_518bba929603
constant: false
initial concentration: NaN
boundary condition: true
name: NDUFB6
is: O95139
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4712
type: Species
initial amount: NaN

metaM 2obut c
is: SBO:0000247
is: C00109
is: HMDB00005
name: 2-Oxobutanoate
is: CHEBI:16763
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false

metaR r2136
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110064#

metaR r0354
kinetic law: MODEL1310110064#
is: SBO:0000176
reversible: false
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110064#

metaR r1665
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110064#
reactant: MODEL1310110064#

metaR GLYC St
name: L-glycerate export
fast: false
reversible: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:

metaM glc D c
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
is: CHEBI:4167
initial amount: NaN
is: HMDB00122

metaR NDPK9n
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_83d283b4_6993_414a_8985_2e280d57c8b2
type: Species
initial amount: NaN
is: P22830
is encoded by: hsa:2235
has only substance units: false
name: FECH
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR ATPtn
kinetic law: MODEL1310110064#
name: ATP diffusion in nucleus
is: SBO:0000185
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
fast: false
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_aa705228_4598_4994_a837_de2998fa4993
is encoded by: hsa:11001
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: O14975
name: SLC27A2

http://identifiers.org/biomodels.db/MODEL1310110064#_fa3ff85c_21af_4c24_a076_dabd8ce19345
is encoded by: hsa:4645
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
name: MYO5B
is: Q9H6Y6
is: SBO:0000252
boundary condition: true
constant: false

metaR r2364
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_8ff11010_3ed7_491f_b2b5_aede20977130
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM ascb L e
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: L-ascorbate
has only substance units: false
is: HMDB00044
initial concentration: 1.0
constant: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
type: Species
is: CHEBI:38290

metaR UDPACGALtl
name: udpacgal intracellular transport
reversible: true
product: MODEL1310110064#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
kinetic law: MODEL1310110064#

metaM rbt c
type: Species
is: SBO:0000247
name: D-ribitol
is: HMDB00508
constant: false
is: CHEBI:15963
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380

http://identifiers.org/biomodels.db/MODEL1310110064#_b1b6b17a_22fb_435e_9338_2a1f025d7d14
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:285973
type: Species
initial amount: NaN
name: ATG9B
is: SBO:0000252
is: Q674R7
has only substance units: false

metaR LPASE
reactant: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
product: MODEL1310110064#
reversible: false
name: lysophospholipase
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.1.5
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ

metaR ADAe
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
reversible: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Adenosine deaminase, extracellular
type: Reaction
modifier: MODEL1310110064#
is: SBO:0000176
fast: false

metaR LEUTAm
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
fast: false
name: leucine transaminase, mitochondrial
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_24fdfd77_73e1_41e5_824b_68bce98d0d5f
type: Species
initial amount: NaN
name: BDH1
initial concentration: NaN
is encoded by: hsa:622
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaR r1923
fast: false
modifier: MODEL1310110064#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110064#
reversible: false
product: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0838
type: Reaction
name: Free diffusion
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.2.4
product: MODEL1310110064#
is: SBO:0000185

metaR RE2972M
modifier: MODEL1310110064#
type: Reaction
name: RE2972
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.1.67
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_a976f47d_2287_4bbb_ae41_fd0f9b4d3ffd
is: SBO:0000252
boundary condition: true
is encoded by: hsa:160851
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: DGKH
initial amount: NaN
is: A8K0I1

metaR r2365
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_eb39ec51_fa65_46b4_bfe5_b557104d4c61
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:224
name: ALDH3A2
has only substance units: false
boundary condition: true
is: P51648
is: SBO:0000252

metaM retinol 9 cis c
name: 9-cis-retinol
is: HMDB06217
is: SBO:0000247
type: Species
is: CHEBI:17336
initial concentration: 1.0
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial amount: NaN
boundary condition: false
has only substance units: false

metaM L2aadp6sa c
boundary condition: false
is: CHEBI:17917
initial concentration: 1.0
constant: false
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false
initial amount: NaN
type: Species
name: L-allysine
is: SBO:0000247

metaR EX cholate LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholate
type: Reaction

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM retinal 11 cis c
is: HMDB02152
type: Species
initial concentration: 1.0
name: 11-cis-retinal
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16066

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR r2060
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: SBO:0000185
product: MODEL1310110064#
is described by: ECO:0000000
modifier: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
type: Reaction

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM 13dampp c
is: SBO:0000247
initial amount: NaN
name: trimethylenediaminium
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00002
type: Species
is: CHEBI:57484
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
boundary condition: false

metaR MTHFD2m
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
product: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
is described by: ECO:0000254
kinetic law: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
reversible: true
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial

metaM 6thf l
boundary condition: false
is: http://identifiers.org/pubchem.compound/169691
initial amount: NaN
type: Species
name: hexaglutamyl folate (THF)
has only substance units: false
constant: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: SBO:0000247
initial concentration: 1.0

metaR r2366
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM ppi r
name: Diphosphate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
is: CHEBI:33019
is: C00013
constant: false
is: HMDB00250

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR r0839
is version of: http://identifiers.org/ec-code/1.3.1.70
reversible: true
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
type: Reaction
reactant: MODEL1310110064#
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_a744e66e_6c64_4231_a885_8aeea1ed0e26
name: UPP2
constant: false
initial amount: NaN
type: Species
is: O95045
boundary condition: true
is encoded by: hsa:151531
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM ascb L c
name: L-ascorbate
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
constant: false
type: Species
is: CHEBI:38290
boundary condition: false

metaM cspg a e
is: C00106
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: SBO:0000247
is: CHEBI:17568
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB00300
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
boundary condition: false

metaM pmtcoa m
is: HMDB01338
constant: false
has only substance units: false
is: C00154
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: CHEBI:57379

metaM rbt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
constant: false
is: CHEBI:15963
name: D-ribitol
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaR Coqe
fast: false
reversible: true
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Transport of q10
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110064#
type: Reaction

metaR GLYCt
product: MODEL1310110064#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
name: glycerol transport via channel

http://identifiers.org/biomodels.db/MODEL1310110064#_ce32ac53_af89_43c0_af78_2c4b2d8b8175
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:3612
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: B7Z6Q4
name: IMPA1

http://identifiers.org/biomodels.db/MODEL1310110064#_30c32244_ec36_4f1e_a64f_11a235e34228
name: SLC7A8:SLC3A2
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:23428
is: SBO:0000297
initial amount: NaN
constant: false
has part: Q86U05

http://identifiers.org/biomodels.db/MODEL1310110064#_8db43d18_58e6_46cc_bf5b_908eb9931d0b
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:6574
initial concentration: NaN
is: Q8WUM9
constant: false
is: SBO:0000252
has only substance units: false
name: SLC20A1

metaR r2367
type: Reaction
reversible: true
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
is: SBO:0000185

metaR r0614
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110064#
reversible: true

metaR r0400
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d086d88b_30f2_4a35_b047_306569193129
initial concentration: NaN
name: NDUFA7
is: Q6FG42
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4701
is: SBO:0000252
has only substance units: false

metaR RE0926E
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
name: RE0926
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is: SBO:0000176

metaM amet m
name: S-Adenosyl-L-methionine
is: HMDB01185
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
boundary condition: false
is: C00019
is: CHEBI:15414
type: Species
has only substance units: false

metaM 6thf m
constant: false
name: hexaglutamyl folate (THF)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
initial amount: NaN
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/169691
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_bf4130c4_ed80_4b44_9f36_77bd17c24210
is: SBO:0000252
constant: false
name: CYP27B1
has only substance units: false
boundary condition: true
is: Q548T3
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1594

metaM txa2 r
initial amount: NaN
is: HMDB01452
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
name: thromboxane A2(1-)
type: Species
initial concentration: 1.0
is: CHEBI:57445

metaR r2368
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_d36ac4a2_d8e6_420e_84ed_7e1fd9ead73e
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6389
type: Species
initial amount: NaN
is: P31040
initial concentration: NaN
name: SDHA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_23be9be8_6c3a_4747_b3df_66ea24983d94
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: Q5JT09
is encoded by: hsa:83549
type: Species
name: UCK1

metaR r0974
name: Active transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
product: MODEL1310110064#

metaR NRPPHRt4 2 r
name: Norepinephrine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_068a93ed_8fa6_4559_b627_ea933ed68867
is: Q8NFF2
is: SBO:0000252
is encoded by: hsa:123041
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
name: SLC24A4

metaM ppi x
is: CHEBI:33019
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
initial amount: NaN
initial concentration: 1.0
name: Diphosphate
has only substance units: false
is: HMDB00250
constant: false

metaR L LACt4r
name: L-lactate reversible transport via sodium symport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
reversible: true

metaM ahcys m
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: C00021
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00939
name: S-Adenosyl-L-homocysteine
constant: false
is: SBO:0000247
is: CHEBI:16680
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_65714f3f_07b9_4dc7_80ed_c1607d623edd
boundary condition: true
has only substance units: false
is encoded by: hsa:7360
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: UGP2
is: SBO:0000252

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_c5943b1c_cb1c_4a3b_9384_a56acef081e7
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:6716
is: SBO:0000252
name: SRD5A2
is: P31213
initial concentration: NaN

metaR H2Otly
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110064#
type: Reaction
reversible: true
name: H2O transport, lysosomal
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_6d27e2dd_8bf6_4de4_b97d_58ca7b1fb02b
has only substance units: false
is: SBO:0000252
constant: false
is: P08319
initial amount: NaN
type: Species
name: ADH4
initial concentration: NaN
boundary condition: true
is encoded by: hsa:127

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM L2aadp c
initial amount: NaN
name: L-2-aminoadipate(1-)
is: CHEBI:58672
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r0616
reversible: true
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
modifier: MODEL1310110064#

metaR r2369
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110064#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_8e610906_cf11_41a0_b403_2ab0c1fcb749
name: NDUFA3
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4696
constant: false
is: O95167
initial amount: NaN

metaR r2419
product: MODEL1310110064#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7

metaM cholate e
is: SBO:0000247
has only substance units: false
type: Species
name: Cholate
is: HMDB00619
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
initial amount: NaN
constant: false
boundary condition: false

metaR GNMT
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.1.1.20
is: SBO:0000176
kinetic law: MODEL1310110064#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
reactant: MODEL1310110064#
reversible: false
name: glycine N-methyltransferase
product: MODEL1310110064#
is described by: ECO:0000269

metaR r0975
kinetic law: MODEL1310110064#
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reactant: MODEL1310110064#

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_63a07701_a2ea_4710_8060_cefc879710ec
is: SBO:0000252
name: SLC16A2
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: P36021
initial amount: NaN
is encoded by: hsa:6567

http://identifiers.org/biomodels.db/MODEL1310110064#_607db64b_82a0_4885_a22e_f93e254a151c
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:23556
name: PIGN
is: O95427
is: SBO:0000252

metaM urate x
name: Urate
constant: false
is: C00366
is: HMDB00289
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: CHEBI:17775
type: Species
boundary condition: false

metaM dgtp n
has only substance units: false
is: C00286
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
name: dGTP
is: HMDB01440

metaM cs b deg2 l
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00812
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
is: CHEBI:16953
notes: FORMULA: C37H54NO41S3 CHARGE: -5
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_c57738d0_ddb4_42db_baed_f13aed6ce069
initial concentration: NaN
type: Species
is encoded by: hsa:54363
boundary condition: true
is: SBO:0000252
is: Q9UJM8
constant: false
has only substance units: false
initial amount: NaN
name: HAO1

metaR ALDD2y
reversible: false
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.36

metaM glucys c
is: C00669
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01049
type: Species
boundary condition: false
name: gamma-L-Glutamyl-L-cysteine
is: CHEBI:58173
constant: false
is: SBO:0000247
notes: FORMULA: C8H13N2O5S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00487 EHMN_ABBREVIATION: C00669

metaR r0202
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
kinetic law: MODEL1310110064#

metaR LDH D
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reversible: true
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110064#
fast: false
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000304
product: MODEL1310110064#
is: SBO:0000176
name: D-lactate dehydrogenase

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM arachdcrn x
constant: false
name: C20:4 carnitine
is: CHEBI:57368
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB06523
initial concentration: 1.0

metaM 5fthf m
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: CHEBI:57457
initial concentration: 1.0
name: 5-formyltetrahydrofolate(2-)
is: HMDB01562
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_23cdba19_970f_40a3_80a4_8983d3fa3b16
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2222
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P37268
name: FDFT1

metaR PAIL4P HStn
reactant: MODEL1310110064#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR RE0691C
product: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
name: RE0691
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_f1342bea_7230_4347_91bb_ba5ca81d557f
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: Q9NP59
name: SLC40A1
has only substance units: false
constant: false
is encoded by: hsa:30061

http://identifiers.org/biomodels.db/MODEL1310110064#_33fc8a5b_dc89_40dc_81fa_2424cd724c2e
has only substance units: false
type: Species
name: ACAT2
is: Q9BWD1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:39
boundary condition: true
initial concentration: NaN
constant: false

metaR r1147
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

metaM ha deg1 l
constant: false
initial amount: NaN
name: hyaluronan degradation product 1
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16336
notes: FORMULA: C22H33N2O16 CHARGE: -1
boundary condition: false

metaM fadh2 r
boundary condition: false
constant: false
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01197

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM atp n
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
type: Species
is: CHEBI:57299
initial concentration: 1.0
is: HMDB00538
is: SBO:0000247
constant: false
has only substance units: false
name: ATP(3-)

http://identifiers.org/biomodels.db/MODEL1310110064#_f8a601be_0206_4968_8a69_0271a417c82c
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: NAGK
is encoded by: hsa:55577
is: SBO:0000252
type: Species
is: Q9UJ70
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_7f857564_092e_41aa_a6ff_356bc05aa226
type: Species
is: P15848
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:411
boundary condition: true
constant: false
name: ARSB
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_2a30d29a_b0f5_4d5a_8ff3_6b5a045e53e1
name: SLC38A1
is: Q9H2H9
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:81539
is: SBO:0000252
initial concentration: NaN

metaR r0618
is described by: ECO:0000000
fast: false
product: MODEL1310110064#
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110064#
reversible: true
type: Reaction
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_bc57ac01_409a_4426_b7b0_ee9a33ded42e
is: P05062
has only substance units: false
constant: false
is encoded by: hsa:229
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: ALDOB
boundary condition: true

metaR ALDD2x
name: aldehyde dehydrogenase (acetaldehyde, NAD)
modifier: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110064#

metaM dnad c
is: HMDB01179
is: CHEBI:18304
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: C00857
name: Deamino-NAD+
has only substance units: false
boundary condition: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_7b970351_dec7_4452_b76f_13439beeac5e
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: E7EPT3
name: ALDH7A1
constant: false
is encoded by: hsa:501
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_e40a5c98_3820_4f90_8466_56aceeabd01e
type: Species
is: O14732
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3613
name: IMPA2

metaR PSP L
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.3.3
kinetic law: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
name: phosphoserine phosphatase (L-serine)

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR PHEMEtm
type: Reaction
reactant: MODEL1310110064#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
name: Heme transport to cytosol
is described by: ECO:0000000

metaM val L m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
constant: false
has only substance units: false
is: HMDB00883
is: CHEBI:16414
name: L-valine

metaR MECOAS1m
is described by: ECO:0000304
fast: false
type: Reaction
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
name: mesaconate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
modifier: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_76f502da_5088_44c4_8120_bd33e74104ff
is encoded by: hsa:4719
type: Species
constant: false
is: P28331
initial amount: NaN
initial concentration: NaN
name: NDUFS1
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_299a2667_c614_4884_92f5_4436aecd068f
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: _AI694761_1_c
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:AI694761

metaM cholate c
has only substance units: false
constant: false
name: Cholate
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00619
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
boundary condition: false
initial amount: NaN

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_e8ad7e34_7108_4639_8315_2416ef18cb12
boundary condition: true
constant: false
is encoded by: hsa:AI378339
type: Species
name: _AI378339_1_m
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR 13DAMPPOX
type: Reaction
modifier: MODEL1310110064#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
product: MODEL1310110064#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

metaR ABUTt2r
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
name: 4-aminobutyrate reversible transport in via proton symport
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
type: Reaction

metaM atp m
is: SBO:0000247
constant: false
is: C00002
is: HMDB00538
boundary condition: false
initial concentration: 1.0
name: ATP(4-)
is: CHEBI:57299
type: Species
has only substance units: false
initial amount: NaN

metaM 1glyc hs e
is: SBO:0000247
is: HMDB00972
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 1 acyl phosphoglycerol
is: CHEBI:57454
initial amount: NaN
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110064#_45fb317f_0eac_4649_8d28_8e4d54e59539
boundary condition: true
is: SBO:0000252
name: NDUFV1
has only substance units: false
is encoded by: hsa:4723
constant: false
initial amount: NaN
is: E5KNH5
initial concentration: NaN
type: Species

metaR r0280
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
type: Reaction
reversible: false
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#

metaR r0130
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:

metaM dctp n
is: CHEBI:16311
boundary condition: false
has only substance units: false
is: SBO:0000247
name: dCTP
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial amount: NaN
type: Species
is: C00458
is: HMDB00998

metaR GLCAASE9ly
modifier: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
name: beta-glucuronidase, lysosomal
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110064#

metaR FAOXC101C8m
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaR CYSTA
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
is described by: ECO:0000304
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
name: cysteine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM

metaR r0830
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000185
reactant: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaM na1 r
initial amount: NaN
constant: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: HMDB00588
has only substance units: false
boundary condition: false
name: sodium(1+)
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29101

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_598e2581_b1fc_4a32_9848_3841b05560db
is: P00338
initial amount: NaN
type: Species
is encoded by: hsa:3939
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: LDHA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c3a30b12_7d91_4752_bf77_7d70aebdf1f2
initial concentration: NaN
has only substance units: false
is: E9KL44
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:3030
name: HADHA

http://identifiers.org/biomodels.db/MODEL1310110064#_6f40985e_67aa_4658_910d_a27b45397225
is: SBO:0000297
boundary condition: true
has part: O95498
initial concentration: NaN
is encoded by: hsa:55350
initial amount: NaN
name: VNN3:VNN2:VNN1
type: Species
constant: false
is encoded by: hsa:8875
has only substance units: false

metaR NADPtru
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
name: NADP transporter, endoplasmic reticulum

metaM dudp n
is: HMDB01000
name: dUDP(3-)
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:60471
initial concentration: 1.0

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM bilglcur r
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:57767
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_ba60c952_8ca3_46af_8988_33a729942a75
name: NDUFA12
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55967
constant: false
type: Species
initial concentration: NaN
is: F8VQS7
initial amount: NaN

metaM HC02216 e
initial concentration: 1.0
is: CHEBI:28922
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1

metaM dctp m
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16311
name: dCTP
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998
boundary condition: false
is: C00458

http://identifiers.org/biomodels.db/MODEL1310110064#_181bc16e_3e33_463c_9d18_799e8146bfbd
is: Q1LZ56
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:206358
name: SLC36A1
initial concentration: NaN

metaM thbpt4acam c
is: HMDB02281
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
boundary condition: false
is: CHEBI:15374
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_5bf7ac84_0507_481f_ac8a_8638bbc43c51
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is: P51648
name: ALDH3A2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:224

metaM 1a25dhvitd3 c
name: calcitriol
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01903
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_35088f7e_6c0c_4f6f_bc4e_7a1406e3f4f4
is: Q99714
is: SBO:0000252
name: HSD17B10
initial amount: NaN
is encoded by: hsa:3028
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_9668a214_b60e_4645_b94d_bb5c4190714c
is: Q9HAS3
boundary condition: true
is: SBO:0000252
constant: false
name: SLC28A3
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:64078

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM 1p3h5c m
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01369
initial amount: NaN
boundary condition: false
type: Species
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: CHEBI:6151

metaM ppa c
initial amount: NaN
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:17272
has only substance units: false
boundary condition: false
name: propionate

http://identifiers.org/biomodels.db/MODEL1310110064#_a7afa7b7_3ce3_40c0_8bbb_41b0ae89ad71
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2678
name: GGT1
is: P19440
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_217856cc_b41b_488a_b6a8_eb3a71abfba3
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: E9KL48
is encoded by: hsa:2746
boundary condition: true
name: GLUD1
initial concentration: NaN

metaM ctp m
is: CHEBI:37563
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: CTP(4-)
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaR VALTAm
reactant: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
is: SBO:0000176
name: valine transaminase, mitochondiral
type: Reaction
reversible: true
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
product: MODEL1310110064#

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_bb4ffe68_5d0a_4892_9ecb_5f7b9c8b3bb7
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: Q99643
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:6391
name: SDHC

http://identifiers.org/biomodels.db/MODEL1310110064#_920f027c_c5d9_449d_b0a1_3c0b214e728d
initial amount: NaN
is encoded by: hsa:55902
initial concentration: NaN
is: Q5QPH3
type: Species
boundary condition: true
has only substance units: false
name: ACSS2
constant: false
is: SBO:0000252

metaM HC00229 e
name: Isomaltose
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: CHEBI:28189
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

metaM pe hs c
constant: false
has only substance units: false
is: CHEBI:16038
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: phosphatidylethanolamine
boundary condition: false

metaR FOLt2le
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185
fast: false
type: Reaction
name: folate transport via anion exchange

metaM cs e deg5 l
has only substance units: false
is: HMDB00868
is: SBO:0000247
constant: false
notes: FORMULA: C31H47NO35S3 CHARGE: -4
boundary condition: false
initial amount: NaN
is: CHEBI:57737
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_96b1403b_6264_46dd_9c02_e1525f04e456
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:AI291895
name: _AI291895_1_c
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_14530b38_9595_46e8_a82a_4c6c3b6d238d
has only substance units: false
is encoded by: hsa:137872
constant: false
name: ADHFE1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q8IWW8

metaR CYSGLYexR
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
is described by: ECO:0000000
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
name: L-cysteine/glycine reversible exchanger
reactant: MODEL1310110064#

metaM e4hglu m
boundary condition: false
type: Species
is: SBO:0000247
name: erythro-4-hydroxy-L-glutamate(1-)
is: HMDB02273
constant: false
is: CHEBI:6331
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM lnlccoa c
name: linoleic coenzyme A
constant: false
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: SBO:0000247
is: HMDB01064
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM 3aib m
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:33094
is: HMDB02166
constant: false
type: Species
initial concentration: 1.0
name: (S)-3-aminoisobutyric acid

metaR PVD3
reversible: true
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110064#
name: Previtamin D3 formation
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT

metaM atp r
is: HMDB00538
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57299
has only substance units: false
name: ATP(4-)
is: C00002
initial concentration: 1.0

metaR RPEc
kinetic law: MODEL1310110064#
fast: false
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
product: MODEL1310110064#
is: SBO:0000176
name: ribulose 5-phosphate 3-epimerase
type: Reaction
reactant: MODEL1310110064#

metaM ctp n
is: HMDB00082
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
is: CHEBI:37563
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_d0ebe8c4_2e88_41cc_838b_79761438cc59
is: SBO:0000252
has only substance units: false
name: LEFTY1
is: O75610
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10637
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_df425cb1_08c0_4e44_b5e6_752ca2acd2a5
type: Species
initial amount: NaN
name: UGT1A8
boundary condition: true
is: Q5DSZ6
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54576
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_75a7ca17_7030_481c_91d0_20f623ec746f
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:25902
is: SBO:0000252
boundary condition: true
name: MTHFD1L
is: B2RD24
constant: false

metaM HC01231 c
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
initial amount: NaN
is: CHEBI:58480
boundary condition: false
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_842c7694_0f9e_46b1_8ff0_c44d79019179
is: P07864
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3948
name: LDHC
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaR PYNP2r
reactant: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.3
is: SBO:0000176
is described by: ECO:0000269
fast: false
name: pyrimidine-nucleoside phosphorylase (uracil)
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#

metaM glyclt c
is: CHEBI:29805
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
name: glycolate
is: HMDB00115
initial concentration: 1.0
type: Species
initial amount: NaN

metaM HC02216 c
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: prostaglandin-f2beta
initial amount: NaN
is: CHEBI:28922
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_0b972a36_b115_4cf5_8921_3671026c7e62
name: PLCZ1
is encoded by: hsa:89869
has only substance units: false
type: Species
boundary condition: true
is: Q86YW0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d31a95ea_a9cb_4949_894f_0fa8220e21fc
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: NT5C2
type: Species
is: P49902
is encoded by: hsa:22978

metaM asp D e
constant: false
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
has only substance units: false
initial concentration: 1.0
name: D-aspartate(1-)
is: HMDB06483
initial amount: NaN
is: CHEBI:29990
type: Species
boundary condition: false

metaM val L c
is: CHEBI:16414
initial concentration: 1.0
is: HMDB00883
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
name: L-valine
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

metaM prostgi2 c
is: HMDB01335
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false
is: CHEBI:57403
name: prostaglandin I2(1-)
initial concentration: 1.0
boundary condition: false
constant: false

metaM ppa e
name: propionate
boundary condition: false
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
is: CHEBI:17272
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00237
type: Species

metaR r2361
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110064#
reversible: true
type: Reaction
reactant: MODEL1310110064#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110064#
fast: false

metaM fadh2 m
name: Flavin adenine dinucleotide reduced
type: Species
is: HMDB01197
initial concentration: 1.0
is: C01352
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58307
boundary condition: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

http://identifiers.org/biomodels.db/MODEL1310110064#_fc3d2c65_ee6a_45d3_b3e0_3722a8d6c69c
has only substance units: false
boundary condition: true
is encoded by: hsa:4200
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is: P23368
name: ME2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_47bc2437_327c_4424_91a8_742f341f6dae
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: _AV717590_1_c
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AV717590

metaR DTDPtn
fast: false
name: dTDP nuclear transport
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110064#
type: Reaction
is: SBO:0000185

metaR r0834
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
product: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR ACACt2m
modifier: MODEL1310110064#
fast: false
name: Acetoacetate mitochondrial transport via H+ symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
type: Reaction
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110064#

metaR r1598
fast: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

metaM mgacpail hs r
constant: false
has only substance units: false
is: HMDB00220
initial amount: NaN
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
boundary condition: false
is: CHEBI:7896
is: C00249
type: Species
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247

metaM lnlccrn m
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: Linoleyl carnitine
type: Species
is: HMDB06469
boundary condition: false

metaM tdchola x
name: taurochenodeoxycholate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00951
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:9407

metaR 3MOBte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: Transport of 3-methyl-2-oxobutanoate
type: Reaction
reversible: true
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM 5adtststerones c
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
type: Species
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_26b69fda_e08b_48ba_80f4_591f4cec03a8
initial amount: NaN
is encoded by: hsa:AI222095
initial concentration: NaN
type: Species
name: _AI222095_1_e
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

metaR r2360
is described by: ECO:0000000
reactant: MODEL1310110064#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110064#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110064#

metaM 4hglusa m
type: Species
is: SBO:0000247
name: L-4-hydroxyglutamic semialdehyde
has only substance units: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: HMDB06556
constant: false
initial amount: NaN
is: CHEBI:27809
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_e1b26e75_67d1_488b_b22f_93614f106d62
type: Species
name: NT5E
is: P21589
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4907
boundary condition: true

metaM ahcys e
initial amount: NaN
is: CHEBI:16680
type: Species
boundary condition: false
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
has only substance units: false
is: HMDB00939
initial concentration: 1.0
constant: false
is: C00021
notes: FORMULA: C14H20N6O5S CHARGE: 0

metaR PPPG9tm
is described by: ECO:0000000
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
name: protoporphyrinogen IX mitochondrial transport
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185

metaR GLYt7 311 r
modifier: MODEL1310110064#
is described by: ECO:0000006
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
type: Reaction
name: glycine reversible transport via sodium and chloride symport (3:1:1)
kinetic law: MODEL1310110064#
reversible: true

metaR DM gpi sig er
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR r1599
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR DAG HSter
reversible: false
is: SBO:0000185
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110064#
name: diacylglycerol ER export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_3ba0242c_95ca_45f8_8375_c014ac6de2ea
has part: P07195
initial amount: NaN
is: SBO:0000297
has only substance units: false
name: LDHA:LDHB
is encoded by: hsa:3939
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3945
has part: P00338
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d742ff38_e871_483d_b142_5e8981ccf371
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:23556
name: PIGN
is: SBO:0000252

metaM asp D c
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: D-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB06483
is: CHEBI:29990

metaR FRDPtcr
product: MODEL1310110064#
reactant: MODEL1310110064#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
type: Reaction
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#

metaR NACHEX3ly
is described by: ECO:0000000
product: MODEL1310110064#
reactant: MODEL1310110064#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reversible: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r1259
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
name: EC:6.2.1.3
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000

metaM val L e
name: L-valine
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00883
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
is: CHEBI:16414

metaM cdp m
name: CDP(3-)
constant: false
is: CHEBI:58069
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01546

http://identifiers.org/biomodels.db/MODEL1310110064#_d8645d71_e150_4334_b9a4_1b4d1e707d90
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1346
initial amount: NaN
name: COX7A1
is: P24310
boundary condition: true
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_49b058d0_f72b_41b3_a75b_36d75d14b286
is encoded by: hsa:51727
name: CMPK1
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: B2R6S5
initial concentration: NaN

metaR AKGMALtm
fast: false
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
name: alpha-ketoglutarate/malate transporter
is: SBO:0000185
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110064#

metaR RE1520M
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: RE1520
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true

metaR r2363
product: MODEL1310110064#
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_159964dd_83f1_455d_9e15_e4a9f80e031f
initial amount: NaN
is encoded by: hsa:AA788780
is: SBO:0000252
type: Species
boundary condition: true
name: _AA788780_1_c
has only substance units: false
initial concentration: NaN
constant: false

metaR r0062
product: MODEL1310110064#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
type: Reaction
name: Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1
is version of: http://identifiers.org/ec-code/4.3.1.17
reactant: MODEL1310110064#
is described by: ECO:0000000

metaR CH25H
kinetic law: MODEL1310110064#
name: cholesterol 25-hydroxylase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.99.38
fast: false
type: Reaction
modifier: MODEL1310110064#
is described by: ECO:0000269
reversible: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110064#

metaM CE2839 e
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: C01936
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: SBO:0000247
name: maltodecaose
initial concentration: 1.0

metaR r0836
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
type: Reaction
fast: false

metaR r1929
name: Y+LAT2 Utilized transport
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
fast: false
modifier: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false

metaR O2St
product: MODEL1310110064#
name: superoxide anion transport via diffusion (extracellular)
is: SBO:0000185
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
reactant: MODEL1310110064#
reversible: true

metaR RE1860E
reactant: MODEL1310110064#
product: MODEL1310110064#
name: RE1860
is version of: http://identifiers.org/ec-code/3.1.4.37
is: SBO:0000176
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (1267.1) SUBSYSTEM: Miscellaneous EC Number: 3.1.4.37 Confidence Level: 0 AUTHORS: PMID:12225906 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction
reversible: true

metaR r1364
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
product: MODEL1310110064#
is described by: ECO:0000000
name: Vesicular transport

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaM 12ppd S c
is: CHEBI:29002
is: SBO:0000247
name: (S)-propane-1,2-diol
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06213
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
constant: false
initial amount: NaN
boundary condition: false

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaM cdp n
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
constant: false
type: Species
name: CDP(3-)
boundary condition: false
initial concentration: 1.0
is: HMDB01546
initial amount: NaN
is: SBO:0000247
is: CHEBI:58069

metaR r1365
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110064#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: Vesicular transport

metaR DGK2m
reversible: true
type: Reaction
kinetic law: MODEL1310110064#
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000176

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM 5adtststerones e
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
constant: false
boundary condition: false
is: HMDB06278
has only substance units: false

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaR r2362
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b4efea6b_b920_49b7_856c_911c297d4368
boundary condition: true
is: SBO:0000252
type: Species
name: ACAT2
is: Q9BWD1
is encoded by: hsa:39
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaM ahcys c
type: Species
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
is: SBO:0000247
is: C00021
initial amount: NaN
constant: false
initial concentration: 1.0
name: S-Adenosyl-L-homocysteine
boundary condition: false
has only substance units: false

metaM cdpchol c
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01413
boundary condition: false
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
name: CDPcholine
is: CHEBI:16436
initial concentration: 1.0
is: SBO:0000247

metaR r0287
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
is described by: ECO:0000000
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110064#
fast: false

metaR ATPtx
kinetic law: MODEL1310110064#
fast: false
name: ATP transporter, peroxisomal
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaR r0835
is: SBO:0000185
reactant: MODEL1310110064#
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110064#

metaR r1928
reversible: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#

metaR LDH L
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
name: L-lactate dehydrogenase
fast: false
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
type: Species
is: CHEBI:57795
initial concentration: 1.0

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR PGMT
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/5.4.2.2
is described by: ECO:0000134
fast: false
modifier: MODEL1310110064#
name: phosphoglucomutase
type: Reaction
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:

metaR LNLCt
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000185
name: Linoleic acid (n-C18:2) transport in via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_7eb2d7f1_ebad_44f0_b264_6cc923e18011
has only substance units: false
type: Species
initial amount: NaN
name: ACADM
is: SBO:0000252
is: P11310
initial concentration: NaN
is encoded by: hsa:34
constant: false
boundary condition: true

metaM arach c
is: CHEBI:32360
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
name: arachidate
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB02212
initial amount: NaN

metaM ocdca c
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
type: Species
has only substance units: false
constant: false
name: stearate
is: CHEBI:25629
is: HMDB00827
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM dlnlcg c
type: Species
is: CHEBI:53486
constant: false
initial amount: NaN
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: HMDB02925
boundary condition: false
initial concentration: 1.0
name: dihomo-gamma-linolenic acid (n-6)
has only substance units: false
is: SBO:0000247

metaM retinol cis 11 e
initial amount: NaN
is: HMDB06216
name: 11-cis-retinol
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
is: CHEBI:16302

metaR r1655
reactant: MODEL1310110064#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_ef5db438_a93f_4a5f_81b9_10659a7f7b09
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:NM 013421
initial amount: NaN
name: _NM_013421_1_e

metaM Ser Thr l
initial amount: NaN
is: HMDB00425
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: protein-linked serine or threonine residue (O-glycosylation site)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_4a294013_b794_48fe_8bd3_5fd7cfa7d74b
boundary condition: true
constant: false
name: COX2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4513
initial concentration: NaN
type: Species
is: Q7GXZ8
initial amount: NaN

metaM pristcoa c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: pristanoyl coa
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
type: Species
is: CHEBI:51341

metaR r1644
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#

metaR ACONTm
modifier: MODEL1310110064#
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110064#
name: Aconitate hydratase
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000134
type: Reaction

metaM taur e
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
name: Taurine
initial concentration: 1.0
is: SBO:0000247
is: HMDB00251
is: CHEBI:3544

metaM arg L e
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
is: HMDB00517
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:32682

metaM citr L m
is: CHEBI:16349
is: HMDB00904
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: L-citrulline
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

metaR r1594
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE1845X
name: RE1845
kinetic law: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110064#
fast: false
is: SBO:0000176
type: Reaction
reversible: true

metaR r2130
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110064#
fast: false
product: MODEL1310110064#

metaR r1257
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
is: SBO:0000176
fast: false
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_485a4248_0817_402a_8614_1225d13621fc
is: Q6IBA0
type: Species
initial amount: NaN
name: NDUFS5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4725
is: SBO:0000252
boundary condition: true
constant: false

metaR RE3565C
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110064#
name: RE3565
reactant: MODEL1310110064#

metaM ppi c
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: C00013
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3
is: SBO:0000247
is: CHEBI:0
type: Species
initial concentration: 1.0
name: Diphosphate

http://identifiers.org/biomodels.db/MODEL1310110064#_67e954d4_4e62_4193_9659_88e8b9612e24
has only substance units: false
initial concentration: NaN
type: Species
name: SDHD
boundary condition: true
is: SBO:0000252
constant: false
is: O14521
initial amount: NaN
is encoded by: hsa:6392

metaR r1656
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#

metaR r1643
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110064#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_4c30a2b7_be9f_4f71_9025_a73e6e670cd4
has only substance units: false
name: RDH14
is encoded by: hsa:57665
initial amount: NaN
type: Species
boundary condition: true
is: Q9HBH5
is: SBO:0000252
constant: false
initial concentration: NaN

metaR RE2799C
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
type: Reaction
name: RE2799
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaM HC01231 m
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58480
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_977d6a28_71bd_4b69_92a5_f1fcf41c75ab
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q16718
is encoded by: hsa:4698
name: NDUFA5
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r0549
product: MODEL1310110064#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.1.1.17
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.6.5.3
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.6.99.3
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
fast: false

metaR r0139
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
reactant: MODEL1310110064#
is described by: ECO:0000000
modifier: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_90860307_08df_463c_af22_18381ec31892
type: Species
constant: false
is encoded by: hsa:124454
name: EARS2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q5JPH6
has only substance units: false
boundary condition: true

metaR 3MOBt2im
reactant: MODEL1310110064#
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
reversible: false
is described by: ECO:0000000
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction

metaR r2131
modifier: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185

metaM cholate r
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 INCHI: InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
is: CHEBI:29747
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00619
boundary condition: false
name: cholate
initial concentration: 1.0

metaM chol e
is: CHEBI:15354
is: C00114
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00097
constant: false
type: Species
is: SBO:0000247
name: Choline
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaR PE HStm
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c847e7cb_c8da_4237_a248_379bb67f7eac
type: Species
constant: false
has only substance units: false
is: Q9BV79
is: SBO:0000252
name: MECR
initial amount: NaN
is encoded by: hsa:51102
boundary condition: true
initial concentration: NaN

metaR r1595
type: Reaction
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#

metaM atp x
initial amount: NaN
boundary condition: false
name: ATP(4-)
is: C00002
type: Species
is: CHEBI:57299
is: SBO:0000247
initial concentration: 1.0
is: HMDB00538
has only substance units: false
constant: false

metaR CDSm
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
is: SBO:0000176
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: phosphatidate cytidylyltransferase
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.7.41
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
type: Reaction
reversible: false

metaM 3aib c
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB02166
name: (S)-3-aminoisobutyric acid
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
boundary condition: false
is: CHEBI:33094

http://identifiers.org/biomodels.db/MODEL1310110064#_27bc274c_67f4_4945_b8b7_1025b02a1acb
has only substance units: false
name: ACO1
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:48
boundary condition: true
constant: false
is: P21399

metaR r2420
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
reactant: MODEL1310110064#
type: Reaction

metaM CE5121 m
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: CHEBI:57449
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
name: trans-3-decenoyl-CoA
constant: false

metaR PIPLC
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110064#
reversible: false
is: SBO:0000176
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
name: phosphatidylinositol phospholipase C
fast: false
type: Reaction
reactant: MODEL1310110064#
is described by: ECO:0000000

metaM dlnlcg e
type: Species
name: dihomo-gamma-linolenic acid (n-6)
has only substance units: false
is: CHEBI:53486
constant: false
initial amount: NaN
is: HMDB02925
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-

http://identifiers.org/biomodels.db/MODEL1310110064#_f57d7e98_8f23_4186_b4da_600aaec58fc0
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:BE966236
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _BE966236_1_c

metaR r1646
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_00f1c487_12ca_4ee7_817c_479714b5d354
is: Q9Y617
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:29968
name: PSAT1
initial concentration: NaN
has only substance units: false

metaR r1657
reversible: true
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false

metaR r1596
is: SBO:0000185
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110064#
reversible: true

metaM retinol cis 11 c
is: CHEBI:16302
constant: false
name: 11-cis-retinol
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB06216
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

http://identifiers.org/biomodels.db/MODEL1310110064#_751b0f32_f61f_4194_b6f8_2611744ff0b6
initial amount: NaN
is encoded by: hsa:219
name: ALDH1B1
constant: false
has only substance units: false
boundary condition: true
is: P30837
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r2132
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#

metaM taur c
is: CHEBI:3544
has only substance units: false
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
initial amount: NaN
name: Taurine
constant: false
is: C00245
initial concentration: 1.0
is: HMDB00251
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f391d202_a23a_47cb_8de3_aaf08f9d9a88
is: SBO:0000252
initial amount: NaN
name: PIGX
type: Species
is encoded by: hsa:54965
constant: false
has only substance units: false
is: Q8TBF5
boundary condition: true
initial concentration: NaN

metaM prostgi2 e
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
initial amount: NaN
has only substance units: false
boundary condition: false
name: prostaglandin I2(1-)
initial concentration: 1.0

metaR GPIAT
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
name: glucosaminylphosphatidyl inositol acetyltransferase
reversible: false
is: SBO:0000176
modifier: MODEL1310110064#
fast: false
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_51dd9b0a_03c2_4600_ac14_66a97c8901bc
type: Species
boundary condition: true
is encoded by: hsa:84812
initial amount: NaN
has only substance units: false
name: PLCD4
is: Q9BRC7
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_53956064_9c05_415e_a3eb_e170e2e6983e
type: Species
name: AOC2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:314
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c35e3882_9fec_40a0_9142_4af7d9be729e
is: Q92536
initial amount: NaN
is encoded by: hsa:9057
initial concentration: NaN
name: SLC7A6
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_babaadbf_5a16_47f9_850a_236cc7d8830f
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:BE042354
type: Species
is: SBO:0000252
constant: false
name: _BE042354_1_m
initial concentration: NaN

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM 3otdcoa m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: CHEBI:28726
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 3-Oxotetradecanoyl-CoA
type: Species
has only substance units: false
is: HMDB03935
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_2cdd00dd_52e9_498b_86dd_a266dc970508
initial concentration: NaN
initial amount: NaN
constant: false
name: NME1
boundary condition: true
has only substance units: false
is encoded by: hsa:4830
type: Species
is: SBO:0000252

metaM ctp e
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:37563
name: CTP(4-)
is: HMDB00082

metaR r0547
kinetic law: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.17.1.4

http://identifiers.org/biomodels.db/MODEL1310110064#_e763c69a_9fd2_4ef8_983b_cf1ac58fe2d6
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000297
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5279
is encoded by: hsa:9091
has part: B2RAU6
is encoded by: hsa:5277
initial amount: NaN
is encoded by: hsa:51227
has part: P57054

metaR r1645
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#

metaM dctp c
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16311
is: SBO:0000247
constant: false
is: HMDB00998
type: Species
name: dCTP
is: C00458

metaR ITCOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
modifier: MODEL1310110064#
is described by: ECO:0000212
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is: SBO:0000176
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaM arg L c
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
has only substance units: false
boundary condition: false
is: HMDB00517
is: SBO:0000247
type: Species
is: CHEBI:32682
initial concentration: 1.0
initial amount: NaN

metaM HC01376 m
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
constant: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
has only substance units: false
initial concentration: 1.0
is: CHEBI:28692
boundary condition: false
type: Species

metaR r1597
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1658
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
product: MODEL1310110064#

metaR METATB0tc
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Methionine into the intestinal cells by ATB0 transporter
type: Reaction

metaM cs a deg4 l
is: CHEBI:16953
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00812
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C31H49NO29S CHARGE: -2
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4

metaM lnlccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: HMDB06469
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: Linoleyl carnitine
type: Species

metaM retn r
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
type: Species
has only substance units: false
is: HMDB01852
initial amount: NaN
initial concentration: 1.0
constant: false
name: all-trans-retinoate
is: SBO:0000247

metaM thbpt4acam n
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial concentration: 1.0
is: HMDB02281
has only substance units: false
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin

http://identifiers.org/biomodels.db/MODEL1310110064#_e5cc9040_886a_461d_8a7b_5053a7dc8cf4
name: COASY
is: SBO:0000252
is encoded by: hsa:80347
boundary condition: true
has only substance units: false
is: Q13057
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR r2133
reactant: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
fast: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_315e7276_3c07_448c_bfdd_d25fd559270d
name: SLC1A2
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:6506
is: SBO:0000252
constant: false
is: P43004
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_3e90812c_ba32_4429_a5d3_e6e2a31b3885
is encoded by: hsa:2821
initial concentration: NaN
name: GPI
initial amount: NaN
constant: false
is: SBO:0000252
is: P06744
has only substance units: false
type: Species
boundary condition: true

metaR UMPK2n
fast: false
name: UMP kinase (CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110064#
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110064#
modifier: MODEL1310110064#

metaR TYRATB0tc
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tyrosine into the intestinal cells by ATB0 transporter
type: Reaction

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM 1a25dhvitd3 n
name: calcitriol
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
initial concentration: 1.0
is: HMDB01903
type: Species
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN

metaM dadp c
boundary condition: false
constant: false
is: C00206
initial amount: NaN
name: dADP
is: CHEBI:57667
is: HMDB01508
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaM 3aib e
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB02166
initial amount: NaN
has only substance units: false
name: (S)-3-aminoisobutyric acid
is: CHEBI:33094
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
constant: false
boundary condition: false

metaM pe hs e
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038
type: Species
boundary condition: false
name: phosphatidylethanolamine
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_d6de0182_3dc4_45d8_b68d_353d69ae08d8
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:248
is: P09923
name: ALPI
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM 1pipdn2c x
initial concentration: 1.0
boundary condition: false
is: CHEBI:16187
constant: false
initial amount: NaN
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: HMDB01084
is: SBO:0000247
name: 1-piperideine-2-carboxylate
has only substance units: false
type: Species

metaR r1648
product: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110064#
fast: false
modifier: MODEL1310110064#

metaM dtmp e
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: dTMP(2-)
is: CHEBI:26999
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_bc0d46e5_a65e_476f_aeaa_f5c64b1d452d
initial amount: NaN
is: SBO:0000252
name: NDUFB6
is: O95139
is encoded by: hsa:4712
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_2b85872c_765d_434d_a3bc_e169b11ce960
boundary condition: true
type: Species
is encoded by: hsa:4729
has only substance units: false
name: NDUFV2
constant: false
initial concentration: NaN
is: SBO:0000252
is: P19404
initial amount: NaN

metaM 2obut m
is: SBO:0000247
is: CHEBI:16763
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
is: HMDB00005
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
name: 2-oxobutanoate
has only substance units: false
boundary condition: false

metaR r1659
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM amet c
is: CHEBI:15414
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00019
type: Species
constant: false
has only substance units: false
name: S-Adenosyl-L-methionine

http://identifiers.org/biomodels.db/MODEL1310110064#_7197f940_6922_4210_92ec_7a3f81f33a4d
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: TREH
boundary condition: true
is encoded by: hsa:11181
is: O43280
constant: false

metaR PROSTGH2t
name: Prostaglandin H2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
reversible: true
fast: false
product: MODEL1310110064#

metaR CYTK7n
is: SBO:0000176
product: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110064#
name: cytidylate kinase (CMP,UTP),nuclear
reversible: true
type: Reaction
fast: false

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#

metaR LTD4DP
fast: false
kinetic law: MODEL1310110064#
name: Leukotriene D4 dipeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM bilglcur e
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
boundary condition: false
is: CHEBI:57767
initial amount: NaN
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
constant: false

metaM Ser Thr g
initial amount: NaN
has only substance units: false
is: CHEBI:0
notes: FORMULA: XH CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: C00124
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110064#_46460291_f336_4e50_9759_4d340c43655f
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI091231_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:AI091231
constant: false

metaM adrncoa x
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
initial concentration: 1.0
is: C16170
name: adrenyl coenzyme A

metaM g3pc c
has only substance units: false
boundary condition: false
is: CHEBI:16870
is: HMDB00086
is: SBO:0000247
constant: false
name: sn-Glycero-3-phosphocholine
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670

http://identifiers.org/biomodels.db/MODEL1310110064#_e0e12a7d_14dc_41e1_95a8_931757aa960d
type: Species
is encoded by: hsa:347734
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: SLC35B2
initial concentration: NaN
boundary condition: true
is: Q8TB61

metaR FAOXC204
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110064#
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM o2s e
name: superoxide
type: Species
initial concentration: 1.0
is: CHEBI:18421
has only substance units: false
constant: false
boundary condition: false
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
initial amount: NaN

metaR r1647
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0545
reversible: true
is described by: ECO:0000000
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM thyox L c
is: CHEBI:18332
initial concentration: 1.0
is: SBO:0000247
name: L-thyroxine
is: HMDB00248
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR PROt2r
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
name: L-proline reversible transport via proton symport
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#

metaM ppa m
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: propionate
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
has only substance units: false
initial amount: NaN
is: CHEBI:17272
initial concentration: 1.0

metaR DSAT
reversible: false
name: dihydrosphingosine N-acyltransferase
is described by: ECO:0000000
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_f98b60f3_c3e5_46c1_bb39_a26ef7d3d7db
is: Q6IBB5
has only substance units: false
is encoded by: hsa:4694
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: NDUFA1
is: SBO:0000252

metaM cs b deg3 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: HMDB02704
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: CHEBI:21338
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b2a8d067_0327_470e_9756_92f578bce9b2
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: PC
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:5091

metaR PLA2 2e
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.4
kinetic law: MODEL1310110064#
is described by: ECO:0000000
name: phospholipase A2
reactant: MODEL1310110064#
reversible: false
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
product: MODEL1310110064#

metaR r1591
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d966e17e_62bc_4da0_8d8c_d9bfefba0e8b
initial amount: NaN
name: PLCB1
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:23236
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_88f439d2_a050_4a34_b2d7_123e83a97717
boundary condition: true
name: _AI915649_1_c
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:AI915649

http://identifiers.org/biomodels.db/MODEL1310110064#_def22f74_7e5c_4d5c_8731_2dd2f9de6b78
initial concentration: NaN
is encoded by: hsa:2589
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: GALNT1
is: Q10472

http://identifiers.org/biomodels.db/MODEL1310110064#_c11c4a01_cc35_4f09_a702_6e85a9d78180
has only substance units: false
is encoded by: hsa:206
boundary condition: true
name: _206_1_c
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaM ocdca e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: SBO:0000247
type: Species
is: CHEBI:25629
name: octadecanoate (n-C18:0)
boundary condition: false
is: C01530
constant: false
initial amount: NaN
is: HMDB00827

metaM dtmp c
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: C00364
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
is: CHEBI:26999
has only substance units: false
is: HMDB01227
name: dTMP
initial concentration: 1.0

metaM fadh2 c
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01197
is: CHEBI:58307
name: FADH2(2-)
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
constant: false
initial amount: NaN
boundary condition: false

metaM cdp e
has only substance units: false
is: CHEBI:58069
name: CDP(3-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: HMDB01546
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaR IDOURtly
fast: false
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
name: iduronate transport into lysososme
product: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM dutp c
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
is: CHEBI:17625
name: dUTP
is: HMDB01191
constant: false
is: SBO:0000247
is: C00460
has only substance units: false
type: Species
initial concentration: 1.0

metaM ppi e
constant: false
is: HMDB00250
name: Diphosphate
is: C00013
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_a4e6e21a_6682_4223_8aa0_5dd5fc348e74
name: _AA177072_1_c
is encoded by: hsa:AA177072
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaM dudp m
has only substance units: false
is: CHEBI:60471
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP(3-)
type: Species
is: HMDB01000
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM xol7ah2al c
type: Species
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
initial concentration: 1.0
is: HMDB06894
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: CHEBI:27428

metaM k e
is: C00238
boundary condition: false
has only substance units: false
initial amount: NaN
name: potassium
constant: false
type: Species
is: CHEBI:29103
initial concentration: 1.0
is: SBO:0000247
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238

metaR r1592
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_696f9ca7_e3f8_468c_a59d_171c8fe740d4
is: P15531
constant: false
has only substance units: false
name: NME1
is encoded by: hsa:4830
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR GALU
is version of: http://identifiers.org/ec-code/2.7.7.9
is: SBO:0000176
name: UTP-glucose-1-phosphate uridylyltransferase
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
is described by: ECO:0000134
product: MODEL1310110064#
fast: false

metaM bilglcur c
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
constant: false
is: CHEBI:57767
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_93e8ec3f_8b2f_4ad4_a309_8ad0f2d8f3be
initial concentration: NaN
constant: false
initial amount: NaN
name: NDUFS6
is encoded by: hsa:4726
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q6IBC4
type: Species

metaM thyox L e
is: HMDB00248
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:18332
boundary condition: false
is: SBO:0000247
name: L-thyroxine
constant: false

metaM o2s c
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
constant: false
is: HMDB02168
name: superoxide

metaR TMDK1
type: Reaction
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
modifier: MODEL1310110064#
name: thymidine kinase (ATP:thymidine)
reactant: MODEL1310110064#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.21
is: SBO:0000176

metaR COt
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
name: CO transporter via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_5fbc11a1_b7f8_4793_ab78_5b1966c23761
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AL050025
boundary condition: true
is: SBO:0000252
name: _AL050025_1_c

http://identifiers.org/biomodels.db/MODEL1310110064#_9a518242_54f1_4cb0_8176_8152753b7fd7
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P07864
name: LDHC
is encoded by: hsa:3948
type: Species
boundary condition: true

metaR r1649
is described by: ECO:0000000
product: MODEL1310110064#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_6f391c47_331e_4994_91c7_08c84069807f
is encoded by: hsa:115286
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC25A26
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_69698d2e_e1ff_4085_a858_bdfcd69521e6
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is: Q9ULD0
initial amount: NaN
has only substance units: false
is encoded by: hsa:55753
name: OGDHL

http://identifiers.org/biomodels.db/MODEL1310110064#_621570dc_03bd_4a20_9497_d6a332d12b44
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:224
name: ALDH3A2
initial concentration: NaN
is: P51648
is: SBO:0000252
type: Species

metaR DHFtm
name: dihydrofolate reversible mitochondrial transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110064#
fast: false

metaM 2oxoadp m
type: Species
name: 2-oxoadipate(2-)
initial concentration: 1.0
is: CHEBI:57499
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial amount: NaN
is: SBO:0000247
is: HMDB00225
boundary condition: false
has only substance units: false
constant: false

metaR r1593
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#

metaM chol c
has only substance units: false
is: C00114
is: CHEBI:15354
is: SBO:0000247
is: HMDB00097
initial amount: NaN
constant: false
initial concentration: 1.0
name: Choline
type: Species
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

http://identifiers.org/biomodels.db/MODEL1310110064#_96cf1867_aff0_4570_a736_2c46eef38396
initial amount: NaN
initial concentration: NaN
is: E5KSL5
boundary condition: true
is encoded by: hsa:1716
type: Species
is: SBO:0000252
name: DGUOK
constant: false
has only substance units: false

metaR PRISTCOAtcx
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_72e99549_1687_4ca1_a595_0e90e7afa846
type: Species
initial concentration: NaN
is encoded by: hsa:80724
boundary condition: true
is: SBO:0000252
constant: false
is: G3XAJ0
has only substance units: false
initial amount: NaN
name: ACAD10

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM lnlncg e
is: CHEBI:32391
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
name: gamma-linolenate
is: HMDB03073
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_d1f86f0b_19fc_48c7_8c3b_d716168a6896
is encoded by: hsa:30
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ACAA1
is: Q96CA6
type: Species

metaM maltpt e
has only substance units: false
is: http://identifiers.org/pubchem.compound/5141
type: Species
initial concentration: 1.0
name: maltopentaose
is: C02052
is: HMDB01296
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM h2o e
type: Species
constant: false
is: SBO:0000247
is: HMDB02111
is: C00001
name: H2O
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
has only substance units: false
is: CHEBI:15377
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_67bf43f1_ea45_4a94_87ed_298c0828bfca
constant: false
is: O95299
name: NDUFA10
is encoded by: hsa:4705
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaM pro D e
initial amount: NaN
is: HMDB03411
is: SBO:0000247
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
name: D-proline
has only substance units: false
is: CHEBI:16313
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_bf7edd1c_6012_47d0_9b4c_68649973f877
constant: false
boundary condition: true
has only substance units: false
name: DGUOK
type: Species
is encoded by: hsa:1716
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_3e8ce553_e146_40bf_b260_906fb60ffd20
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4698
type: Species
is: Q16718
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: NDUFA5

metaR r2201
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110064#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185

metaR UGT1A10r
reversible: true
is version of: http://identifiers.org/ec-code/2.4.1.17
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110064#
type: Reaction
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
modifier: MODEL1310110064#
fast: false

metaM arachdcrn c
initial amount: NaN
is: CHEBI:57387
constant: false
name: C20:4 carnitine
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01322
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
initial concentration: 1.0

metaR RE2677C
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
is: SBO:0000176
reactant: MODEL1310110064#
name: RE2677
type: Reaction
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110064#

metaR CYOR u10m
is: SBO:0000185
fast: false
name: ubiquinol-6 cytochrome c reductase, Complex III
reactant: MODEL1310110064#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110064#

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaM man c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:16024
name: D-Mannose
is: HMDB00169
type: Species
is: C00159
initial amount: NaN

metaR DATPtn
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110064#
type: Reaction
fast: false
name: dATP diffusion in nucleus
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR PHCDm
modifier: MODEL1310110064#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is described by: ECO:0000304
fast: false
type: Reaction
reactant: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110064#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_655e5e90_f560_4bb8_8839_78f23c5e2b55
has only substance units: false
type: Species
is encoded by: hsa:84264
initial amount: NaN
is: SBO:0000252
is: Q6PII5
name: HAGHL
constant: false
boundary condition: true
initial concentration: NaN

metaR r0960
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1

metaR DCSPTN1CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase
fast: false
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_9fd0b9db_cb18_41b2_91a9_0f3d6a3b00c5
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51604
name: PIGT
is: Q969N2
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaM na1 c
is: C01330
constant: false
initial concentration: 1.0
is: HMDB00588
is: CHEBI:4541
notes: FORMULA: Na CHARGE: 1
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
name: Sodium
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_2e5e8ea7_d9bf_48eb_ba46_33735e6a8a0d
has only substance units: false
boundary condition: true
is: P08195
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6520
name: SLC3A2
constant: false
initial concentration: NaN
type: Species

metaR ADSK
is: SBO:0000176
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
reversible: false
fast: false
name: adenylyl-sulfate kinase
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction

metaM o2s n
name: superoxide
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
constant: false
is: HMDB02168
is: CHEBI:18421
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM 2mbcoa m
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57336
name: 2-methylbutanoyl-CoA(4-)
constant: false
is: HMDB01041

metaR r2202
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_17ca3cb6_fa6e_4ade_bb5f_87eea927be0b
initial concentration: NaN
constant: false
is: P30613
has only substance units: false
name: PKLR
is encoded by: hsa:5313
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaM urate e
name: Urate
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00366
constant: false
is: CHEBI:17775
is: SBO:0000247
is: HMDB00289
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM HC01397 m
type: Species
is: CHEBI:27402
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
name: (S)-3-Hydroxyhexadecanoyl-CoA

metaM kdnp c
notes: FORMULA: C9H14O12P CHARGE: -3
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate
is: HMDB01078
is: CHEBI:17369
initial concentration: 1.0
type: Species

metaR DCSPTN1CPT2
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110064#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
name: carnitine transferase

metaM h n
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
is: CHEBI:24636
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_ec5d8a54_ccf3_4fa6_88f7_ee92fdbaee6a
initial amount: NaN
name: _AV717590_1_m
is encoded by: hsa:AV717590
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_a811305b_1b7d_4500_81ff_4595b67c4524
is: Q9NX14
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54539
name: NDUFB11
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaM vitd3 c
boundary condition: false
constant: false
has only substance units: false
type: Species
name: calciol
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial amount: NaN
is: CHEBI:28940
is: HMDB00876
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_0543b50f_d740_4a53_a6b7_def824463d14
constant: false
is: SBO:0000252
is encoded by: hsa:9843
name: HEPH
type: Species
initial concentration: NaN
is: E9PHN8
initial amount: NaN
boundary condition: true
has only substance units: false

metaM nicrnt c
has only substance units: false
is: HMDB01132
boundary condition: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57502
is: C01185
is: SBO:0000247
constant: false
name: Nicotinate D-ribonucleotide

metaM glyc R c
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16659
is: HMDB00139

metaM lnlncg c
initial amount: NaN
boundary condition: false
is: HMDB03073
is: CHEBI:32391
type: Species
name: gamma-linolenate
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0

metaM h2o g
boundary condition: false
is: CHEBI:15377
constant: false
is: SBO:0000247
is: HMDB02111
type: Species
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
name: water
initial concentration: 1.0

metaM arachd l
name: arachidonate
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
has only substance units: false
is: HMDB01043
boundary condition: false
type: Species
is: CHEBI:32395
initial amount: NaN
initial concentration: 1.0

metaR r2079
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_8df8caf5_b675_4f21_b18b_c1a615f1c9ae
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q16348
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6565
constant: false
name: SLC15A2
type: Species

metaM 23cump e
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H10N2O8P CHARGE: -1 INCHI: InChI=1S/C9H11N2O8P/c12-3-4-6-7(19-20(15,16)18-6)8(17-4)11-2-1-5(13)10-9(11)14/h1-2,4,6-8,12H,3H2,(H,15,16)(H,10,13,14)/p-1/t4-,6-,7-,8-/m1/s1 EHMN_ABBREVIATION: C02355
name: 2',3'-cyclic UMP(1-)
initial concentration: 1.0
constant: false
is: CHEBI:60873
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_35cb7e8a_599e_460e_bee2_262830547fc8
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2639
initial amount: NaN
is: Q92947
name: GCDH

metaM pro D c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB03411
is: CHEBI:16313
boundary condition: false
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247
has only substance units: false

metaR r0779
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_ff588b79_20cf_4424_855a_ebce21c1625d
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI222095
boundary condition: true
is: SBO:0000252
name: _AI222095_1_m
type: Species

metaR ARACHt
reactant: MODEL1310110064#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
name: fatty acid transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_4acffa0b_de21_4b40_be94_8c70376e1370
type: Species
has only substance units: false
boundary condition: true
is: Q3I5F7
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:641372
name: ACOT6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_eb44f20b_e7b9_4197_b89b_e9ba4d2db36f
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q86YT5
is encoded by: hsa:284111
name: SLC13A5
constant: false

metaM pe hs r
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: phosphatidylethanolamine
is: SBO:0000247
is: CHEBI:16038

metaM arg L m
name: L-argininium(1+)
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:32682
is: HMDB00517
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
constant: false

metaR HISTAtu
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Histamine uniport
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR r2200
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110064#
product: MODEL1310110064#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_4a36cbbf_bf2d_4c8b_bd2e_0fcbcf883bb6
is encoded by: hsa:10948
name: STARD3
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: B4DUY1
is: SBO:0000252

metaR THRGLNexR
is: SBO:0000185
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110064#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110064#

metaM pail hs n
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial amount: NaN
is: CHEBI:57880
is: SBO:0000247

metaR r1671
modifier: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
name: Y+LAT2 Utilized transport
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_942197f4_aff3_4bd2_86ee_e397b08efa37
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:218
constant: false
is: P30838
type: Species
name: ALDH3A1
initial concentration: NaN
has only substance units: false

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaR PETOHMm hs
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
name: phosphatidylethanolamine N-methyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
is: SBO:0000176
is described by: ECO:0000254
type: Reaction

metaM urate c
is: SBO:0000247
is: HMDB00289
name: Urate
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00366
is: CHEBI:17775
constant: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

http://identifiers.org/biomodels.db/MODEL1310110064#_a0dfc578_093f_4282_b769_30aefa98c2ef
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:56474
is: Q9NRF8
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: CTPS2

metaM 42A3HP24DB c
is: http://identifiers.org/pubchem.compound/7956
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
constant: false
has only substance units: false
is: HMDB04083
is: C05645
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_38a162ad_eeae_42a9_9d3c_3f4fda454dcd
is: P28330
constant: false
boundary condition: true
initial concentration: NaN
name: ACADL
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:33
has only substance units: false

metaR GGH 6DHFe
type: Reaction
name: Gamma-glutamyl hydrolase (6DHF), extracellular
reactant: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_20d46887_1c04_4a65_b65c_298a2a548b7f
has only substance units: false
is encoded by: hsa:51227
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: PIGP

http://identifiers.org/biomodels.db/MODEL1310110064#_2c457a01_df17_413c_9969_75b813020e93
is encoded by: hsa:4538
is: P03905
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: ND4
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_de9a5292_90aa_4e67_905b_cb961f51b26f
initial concentration: NaN
is encoded by: hsa:158
name: ADSL
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaM pail45p hs m
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
is: CHEBI:28910
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR SQLSr
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110064#
is described by: ECO:0000134
fast: false
reversible: false
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000176
name: Squalene synthase
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ

http://identifiers.org/biomodels.db/MODEL1310110064#_03db6c8f_4d86_426d_b8bc_84d0daa602b4
name: UPP1
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7378
boundary condition: true
is: SBO:0000252

metaM lald D c
is: CHEBI:17167
name: (R)-lactaldehyde
type: Species
initial concentration: 1.0
is: HMDB06458
initial amount: NaN
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

metaM leuktrE4 e
type: Species
boundary condition: false
has only substance units: false
name: leukotriene E4(1-)
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57462
is: HMDB02200
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: SBO:0000247

metaM vitd3 e
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
name: calciol
is: CHEBI:28940
is: SBO:0000247
is: HMDB00876

metaM dd2coa m
boundary condition: false
initial amount: NaN
name: trans-dodec-2-enoyl-CoA(4-)
is: CHEBI:57330
constant: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB03712

metaM cgly e
initial amount: NaN
type: Species
constant: false
name: L-cysteinylglycine
initial concentration: 1.0
is: HMDB00078
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
has only substance units: false
is: SBO:0000247
is: CHEBI:4047

metaM HC02210 e
name: prostaglandin-d3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:34939
has only substance units: false
constant: false
initial concentration: 1.0

metaM malthx e
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial concentration: 1.0
boundary condition: false
name: Maltohexaose
constant: false
is: C01936
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_10481318_6cb0_4e4b_9a95_87b16fb92145
is encoded by: hsa:1350
has part: P14854
is encoded by: hsa:84701
has part: P12074
has part: Q02221
has part: P24311
is encoded by: hsa:1345
is encoded by: hsa:170712
type: Species
has part: P15954
is encoded by: hsa:1340
is encoded by: hsa:4512
has part: P09669
is encoded by: hsa:125965
is encoded by: hsa:9167
has part: Q53YB7
boundary condition: true
is encoded by: hsa:1349
is encoded by: hsa:1337
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:4514
has part: Q7GXZ8
has part: Q6FGA0
is encoded by: hsa:1351
is encoded by: hsa:9377
has part: P24310
has part: P00414
has only substance units: false
constant: false
has part: Q53XN1
is encoded by: hsa:1339
is encoded by: hsa:1327
is encoded by: hsa:1329
has part: P20674
has part: H0UI06
has part: Q6YFQ2
is encoded by: hsa:341947
is encoded by: hsa:4513
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: Q7GXY8
has part: Q96KJ9
is encoded by: hsa:1346
has part: Q8TF08
initial amount: NaN
has part: P13073
has part: Q7Z4L0
is encoded by: hsa:1347

http://identifiers.org/biomodels.db/MODEL1310110064#_8f6e46e7_9d8b_40a7_9271_823873448873
initial concentration: NaN
name: BCAT2
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:587
is: O15382
is: SBO:0000252
boundary condition: true

metaR r1641
kinetic law: MODEL1310110064#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM arachd e
has only substance units: false
is: HMDB01043
initial amount: NaN
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
boundary condition: false
is: CHEBI:32395
is: SBO:0000247
name: arachidonate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_83d98880_ea47_4116_8309_456ab721d0e7
type: Species
initial amount: NaN
name: _AU149534_1_c
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AU149534
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_7a1ebb7b_99f5_4152_b410_4acb1f0427f3
type: Species
boundary condition: true
is encoded by: hsa:4731
initial amount: NaN
has only substance units: false
is: P56181
initial concentration: NaN
is: SBO:0000252
constant: false
name: NDUFV3

metaR GLUTCOADHm
is: SBO:0000176
reactant: MODEL1310110064#
is described by: ECO:0000304
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: glutaryl-CoA dehydrogenase (mitochondria)
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.99.7

http://identifiers.org/biomodels.db/MODEL1310110064#_e457a159_1479_46eb_a345_86b5e78e4526
initial concentration: NaN
name: AHCY
type: Species
is: B3KUN3
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:191
constant: false

metaR GGH 5THFe
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110064#
name: Gamma-glutamyl hydrolase (5THF), extracellular

metaM h r
type: Species
is: C00080
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:24636
name: proton

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_5f6e4dfd_d144_4537_91e6_b91f580fff48
is encoded by: hsa:4709
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: NDUFB3
initial concentration: NaN
is: Q6IB80
has only substance units: false

metaR ALAGLYexR
modifier: MODEL1310110064#
fast: false
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
name: L-alanine/glycine reversible exchange
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304

metaR r1642
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM acald e
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15343
is: HMDB00990
boundary condition: false

metaM dhcrm hs c
boundary condition: false
is: CHEBI:31488
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: dihydroceramide
is: SBO:0000247
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126

http://identifiers.org/biomodels.db/MODEL1310110064#_e720de9f_efb4_4bd7_8bcc_f31f2d0194e2
is encoded by: hsa:953
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ENTPD1
initial concentration: NaN
constant: false
type: Species
is: Q86VV3
has only substance units: false

metaM dadp m
has only substance units: false
is: HMDB01508
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57667
type: Species
name: dADP(3-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

http://identifiers.org/biomodels.db/MODEL1310110064#_b42992c8_6448_4361_b86a_c5f586234b68
is: P30048
is encoded by: hsa:10935
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PRDX3

metaM o2s m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB02168
type: Species
is: C00704
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: Superoxide anion
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:18421

metaM h2o c
is: SBO:0000247
name: H2O
is: HMDB02111
initial amount: NaN
is: C00001
boundary condition: false
constant: false
is: CHEBI:3303
type: Species
notes: FORMULA: H2O CHARGE: 0
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_bbb5873d_6b8d_41d9_9673_9b46b99f46a9
name: SLC4A2
has only substance units: false
is encoded by: hsa:6522
is: F8W682
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM 10fthf6glu e
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](6)
is: SBO:0000247
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
constant: false
is: HMDB00972
type: Species
is: CHEBI:57454
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_74c31b8b_2197_47e0_a730_619bb7bb6a5d
has only substance units: false
initial amount: NaN
name: CTSA
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:5476
is: P10619

metaR NACHEX2ly
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110064#_dfcfecc2_7eca_45dd_aab2_081b863e7a31
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:222
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ALDH3B2
is: P48448

http://identifiers.org/biomodels.db/MODEL1310110064#_902706da_daec_4209_b28b_dd48343444e3
constant: false
name: _AI971036_1_c
is encoded by: hsa:AI971036
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM cgly c
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:4047
initial concentration: 1.0
is: HMDB00078
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine

metaM gacpail hs c
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00128
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
name: glucosaminyl-acylphosphatidylinositol
is: SBO:0000247
is: CHEBI:16344
boundary condition: false
initial amount: NaN
constant: false

metaR r0365
fast: false
type: Reaction
product: MODEL1310110064#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
modifier: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: false

metaM prostgi2 r
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin I2(1-)
is: HMDB01335
constant: false
type: Species
is: CHEBI:57403
boundary condition: false

metaM dadp n
boundary condition: false
is: HMDB01508
has only substance units: false
constant: false
name: dADP(3-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57667
type: Species
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN

metaR ASPTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
kinetic law: MODEL1310110064#
name: aspartate transaminase
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
reactant: MODEL1310110064#

metaM pail45p hs n
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:28910
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR RE3567C
fast: false
reversible: true
reactant: MODEL1310110064#
name: RE3567
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176

metaR r0560
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
is: SBO:0000176
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
is described by: ECO:0000000

metaR HXPRT
kinetic law: MODEL1310110064#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
reactant: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
type: Reaction
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8
modifier: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_fd0edbd5_e818_4378_9b16_472821bfab4d
name: CLC
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: C5HZ13
is encoded by: hsa:1178

metaM pe hs m
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16038
has only substance units: false

metaR r0774
modifier: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110064#_d55a93d0_6bc4_42d5_af4a_7d742b2c7c32
is: P59796
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:257202
name: GPX6
initial concentration: NaN
boundary condition: true

metaM acald c
is: HMDB00990
name: acetaldehyde
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15343
initial amount: NaN
has only substance units: false

metaR r1640
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
fast: false

metaM CE2435 m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
name: trans,cis-deca-2,4-dienoyl-CoA
boundary condition: false
initial concentration: 1.0
is: CHEBI:57795
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaR NDPK8n
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110064#
is: SBO:0000176
fast: false
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR q10tm
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
name: transport of ubiquinone into mitochondria
is: SBO:0000185
reactant: MODEL1310110064#
type: Reaction
fast: false

metaM HC01415 m
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: (2E)-Octenoyl-CoA
boundary condition: false
is: CHEBI:27537
constant: false

metaR H2O2t
reactant: MODEL1310110064#
type: Reaction
name: hydrogen peroxide transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
kinetic law: MODEL1310110064#
reversible: true

metaR r0968
type: Reaction
name: Postulated transport reaction
reversible: false
is: SBO:0000185
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

metaR r0210
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 0 AUTHORS: PMID:681363 NOTES:
kinetic law: MODEL1310110064#
reversible: false
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
name: L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22

metaR H2CO3D
product: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
name: carboxylic acid dissociation
reactant: MODEL1310110064#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
type: Reaction

metaM o2s x
initial concentration: 1.0
constant: false
name: superoxide
is: HMDB02168
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:18421
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247

metaR DHCR241r
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
product: MODEL1310110064#
is: SBO:0000176
name: 24-dehydrocholesterol reductase [Precursor]

metaR LPCHOLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
name: lysophosphatidylcholine transport
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185

metaR NICRNTtn
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
name: NICRNT transport, nuclear trhough pore
kinetic law: MODEL1310110064#

metaM kdn c
initial amount: NaN
is: HMDB00425
notes: FORMULA: C9H15O9 CHARGE: -1 INCHI: InChI=1/C9H16O9/c10-2-5(13)7(15)8(16)6(14)3(11)1-4(12)9(17)18/h3,5-8,10-11,13-16H,1-2H2,(H,17,18)/t3-,5-,6+,7+,8+/m0/s1
has only substance units: false
is: SBO:0000247
type: Species
constant: false
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_eb6a1bcc_5ba1_40e0_b76c_fea5f4906e80
is: B7Z1R0
initial concentration: NaN
name: SLC4A10
is encoded by: hsa:57282
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM co2 e
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16526
is: C00011
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
boundary condition: false
is: HMDB01967
name: CO2
type: Species

metaM cmp e
constant: false
has only substance units: false
initial concentration: 1.0
name: CMP(2-)
is: CHEBI:60377
is: HMDB00095
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_303be7c9_efd8_4496_a3c2_3e63defbc209
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: CLYBL
is: Q8N0X4
is encoded by: hsa:171425
has only substance units: false

metaR UGLCNACtg
kinetic law: MODEL1310110064#
name: UDP-GlcNAc Golgi transport via CMP antiport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reactant: MODEL1310110064#
is: SBO:0000185
reversible: true
product: MODEL1310110064#
type: Reaction
fast: false
modifier: MODEL1310110064#

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR r2354
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#

metaR RAI1
is: SBO:0000176
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
name: retinal isomerase (11-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false

metaM 3hpp m
is: HMDB00700
constant: false
is: CHEBI:16510
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 3-hydroxypropionate
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013

metaR DPCOAK
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110064#
name: dephospho-CoA kinase
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.3
reversible: false
is: SBO:0000176
is described by: ECO:0000269

metaR r2355
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
type: Reaction

metaM dgchol e
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: glycochenodeoxycholate
is: HMDB00637
type: Species
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252

http://identifiers.org/biomodels.db/MODEL1310110064#_6344150f_1c19_41b4_91ef_c47625f2015b
name: ACOX1
type: Species
is encoded by: hsa:51
has only substance units: false
is: B4DK61
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaM cdpdag hs m
constant: false
type: Species
initial amount: NaN
name: CDP-diacylglycerol(2-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
boundary condition: false

metaR GLNS
fast: false
product: MODEL1310110064#
name: glutamine synthetase
is: SBO:0000176
reversible: false
reactant: MODEL1310110064#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/4.1.1.15
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_65742cb0_160e_4eaf_b7ef_67df86910b2e
initial amount: NaN
is: SBO:0000252
name: _NOS2A_1_c
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:NOS2A
has only substance units: false
boundary condition: true

metaM HC00342 c
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
name: cis-aconitate(3-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_348de7dc_40be_45bd_83f0_29fae071166b
type: Species
is encoded by: hsa:873
constant: false
initial amount: NaN
boundary condition: true
name: CBR1
is: P16152
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_a7b01d2c_8d13_499f_ae0d_537e94db5e6a
type: Species
boundary condition: true
initial amount: NaN
name: PI4KB
initial concentration: NaN
is: Q9UBF8
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5298
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_0b230cc0_c872_4104_9604_6c6b53806075
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1109
boundary condition: true
type: Species
is: P17516
initial amount: NaN
has only substance units: false
name: AKR1C4
constant: false

metaM arachd c
is: CHEBI:32395
is: SBO:0000247
type: Species
is: HMDB01043
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

metaR r1934
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
name: Y+LAT2 Utilized transport

metaR GLYtm
reversible: true
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is: SBO:0000185
reactant: MODEL1310110064#
name: glycine passive transport to mitochondria
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_4d16241a_0e0f_45e0_8d51_9c98bbb4afba
type: Species
is: Q8N695
initial concentration: NaN
name: SLC5A8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:160728
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_dccf2a3f_c892_493f_8d16_65bfaeb79ec0
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
name: _H77542_1_r
is: SBO:0000252
is encoded by: hsa:H77542
initial concentration: NaN

metaR DNDPt56m
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
fast: false
name: dCTP transport via ATP antiport
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaM lald L c
name: (S)-lactaldehyde
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB03052
boundary condition: false
is: SBO:0000247
is: CHEBI:18041
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1

metaM dcsptn1coa c
constant: false
is: C16173
is: SBO:0000247
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
boundary condition: false
is: HMDB06513
initial concentration: 1.0
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/47205483
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

metaR r2352
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#

metaR LYSOXp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
type: Reaction
product: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
name: L-lysine oxidase, peroxisomal
is described by: ECO:0000000
fast: false

metaR MTHFDm
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is version of: http://identifiers.org/ec-code/6.3.4.3

metaR GSNt
fast: false
name: guanosine facilated transport in cytosol
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

metaR NACHEX27ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110064#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000269
modifier: MODEL1310110064#
reversible: false
fast: false
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
product: MODEL1310110064#

metaR HPYRDC
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
product: MODEL1310110064#
is described by: ECO:0000000
reversible: false
type: Reaction
name: hydroxypyruvate decarboxylase
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is: SBO:0000176

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM hxan c
is: CHEBI:17368
has only substance units: false
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
boundary condition: false
is: HMDB00157
constant: false
type: Species
initial concentration: 1.0
is: C00262
is: SBO:0000247
initial amount: NaN
name: Hypoxanthine

http://identifiers.org/biomodels.db/MODEL1310110064#_ce7e6ef3_ee65_4398_be8f_59a134ee0e44
constant: false
is: SBO:0000252
initial concentration: NaN
is: O00483
is encoded by: hsa:4697
initial amount: NaN
boundary condition: true
name: NDUFA4
type: Species
has only substance units: false

metaM pep m
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
has only substance units: false
initial concentration: 1.0
is: CHEBI:18021
is: HMDB00263
is: C00074
name: Phosphoenolpyruvate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_eeb9236b_1fbc_4157_b27b_555cc81a063f
has only substance units: false
initial concentration: NaN
type: Species
name: _AL038231_1_c
boundary condition: true
is encoded by: hsa:AL038231
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c0320e7d_147d_418b_bbe3_0ffb6ce8af9e
initial concentration: NaN
name: CTPS1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1503
initial amount: NaN
type: Species
is: P17812
boundary condition: true
constant: false

metaM C05280 m
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: cis,cis-3,6-Dodecadienoyl-CoA
is: SBO:0000247
is: CHEBI:28002
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
is: HMDB03952

http://identifiers.org/biomodels.db/MODEL1310110064#_1e98e2bd_01ee_403c_b9f2_b63258748bc8
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: IDS
is encoded by: hsa:3423
is: P22304

metaR r2353
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110064#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

metaM triodthy c
is: HMDB00265
initial amount: NaN
name: 3,3',5-triiodo-L-thyronine
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:18258
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false

metaR r0360
fast: false
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
type: Reaction
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176

metaM lnlncg l
constant: false
is: CHEBI:32391
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: HMDB03073
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: gamma-linolenate

metaM h x
is: C00080
name: proton
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR NH4tp
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
name: ammonia peroxisomal transport
reversible: true
reactant: MODEL1310110064#

metaR r1932
product: MODEL1310110064#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false

metaM sphgn c
name: sphinganine(1+)
is: SBO:0000247
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
boundary condition: false
has only substance units: false
is: CHEBI:57817
type: Species
is: HMDB00269
initial amount: NaN
initial concentration: 1.0
constant: false

metaM retn e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:35291
initial amount: NaN
name: all-trans-retinoate
is: HMDB01852
boundary condition: false
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false

metaR r0629
is version of: http://identifiers.org/ec-code/3.6.1.22
reactant: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: true
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65

metaR r2358
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110064#

metaM pro L m
is: HMDB00162
initial amount: NaN
has only substance units: false
is: CHEBI:17203
is: SBO:0000247
name: L-proline
initial concentration: 1.0
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_35a57011_f718_453e_bcdd_4069bd4b61a5
initial concentration: NaN
name: PCBD2
has only substance units: false
constant: false
initial amount: NaN
is: Q9H0N5
is: SBO:0000252
is encoded by: hsa:84105
boundary condition: true
type: Species

metaR PEPCKm
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
type: Reaction
name: Phosphoenolpyruvate carboxykinase (GTP)
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.1.1.32
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reversible: false
product: MODEL1310110064#

metaR r1670
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: Y+LAT2 Utilized transport

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR CSPG Etly
reversible: false
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
name: chondroitin sulfate E transport, extracellular to lysosome
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR CHLPCTD
product: MODEL1310110064#
modifier: MODEL1310110064#
reversible: false
name: choline phosphate cytididyltransferase
is described by: ECO:0000269
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.15
reactant: MODEL1310110064#
fast: false

metaM uppg3 c
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: C01051
boundary condition: false
name: Uroporphyrinogen III
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
is: CHEBI:57308
is: HMDB01086
is: SBO:0000247
initial amount: NaN

metaM CE0693 m
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
has only substance units: false
name: 3-oxolaur-6-cis-enoyl-CoA
boundary condition: false
type: Species
is: HMDB11123
is: CHEBI:28387
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM hco3 m
type: Species
is: HMDB00595
initial amount: NaN
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
is: CHEBI:17544
initial concentration: 1.0
has only substance units: false
is: C00288
name: Bicarbonate
is: SBO:0000247

metaR CITL
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
kinetic law: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
is described by: ECO:0000000
name: Citrate lyase
type: Reaction
is: SBO:0000176
reversible: false

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR GALtly
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110064#
name: galactose efflux from lysosome

http://identifiers.org/biomodels.db/MODEL1310110064#_7ad56b3c_f141_490d_b925_806ec295374b
type: Species
initial concentration: NaN
is encoded by: hsa:170712
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: Q8TF08
name: COX7B2

http://identifiers.org/biomodels.db/MODEL1310110064#_f19ce139_7a6a_442d_abad_606ed6a3fea3
boundary condition: true
constant: false
is encoded by: hsa:218
initial amount: NaN
name: ALDH3A1
has only substance units: false
initial concentration: NaN
is: P30838
is: SBO:0000252
type: Species

metaR ACHtn
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: Acetylcholin transport, nuclear trhough pores
product: MODEL1310110064#
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_3c37deb6_c15d_4700_a557_4631c6e7619f
is: Q9BZV2
initial concentration: NaN
name: SLC19A3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:80704
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR r1933
modifier: MODEL1310110064#
reversible: false
product: MODEL1310110064#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_5c6e5462_4c60_40fb_8277_9dbc7424dc7a
constant: false
initial concentration: NaN
name: AHCYL1
has only substance units: false
is encoded by: hsa:10768
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM 56dthm m
is: SBO:0000247
boundary condition: false
is: CHEBI:27468
has only substance units: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
constant: false
name: 5,6-dihydrothymine
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00079

metaM hxan e
name: hypoxanthine
is: HMDB00157
is: CHEBI:17368
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b30838cf_a7a5_4a0f_9e0c_2d377ee2db36
type: Species
constant: false
initial concentration: NaN
name: KL
is encoded by: hsa:9365
is: Q9UEF7
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM triodthy e
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
constant: false
type: Species
boundary condition: false
is: HMDB00265
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM mi1p D c
initial concentration: 1.0
name: 1D-myo-inositol 1-phosphate(2-)
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB02985
is: CHEBI:58433

metaM glutcoa m
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: glutaryl-CoA(5-)
is: CHEBI:57378
is: HMDB01339
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
has only substance units: false
initial concentration: 1.0
type: Species

metaM succ x
is: HMDB00254
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
is: C00042
is: CHEBI:30031
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR r2359
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110064#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#

metaR GALt4
fast: false
name: galactose transport via sodium symport
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000269
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
is: SBO:0000185
modifier: MODEL1310110064#
reactant: MODEL1310110064#

metaR MCLACCYSR
name: 3-mercaptolactate:cysteine reductase
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
reversible: false
is: SBO:0000176
type: Reaction

metaM sph1p e
is: SBO:0000247
is: HMDB01383
initial amount: NaN
is: CHEBI:57939
boundary condition: false
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_35989a4e_0d48_41f6_8d85_201fff787f7b
is: P17174
is encoded by: hsa:2805
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: GOT1
constant: false
type: Species
is: SBO:0000252

metaM retn c
boundary condition: false
name: all-trans-retinoate
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
is: HMDB01852
is: SBO:0000247

metaR GGH 5THFl
type: Reaction
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (5THF), lysosomal
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reactant: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
is: SBO:0000176

metaR DCSPTN1CRNt
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
reversible: false
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: transport into the mitochondria (carnitine)

metaR r1930
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110064#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110064#
reversible: false
product: MODEL1310110064#

metaR RE2677E
product: MODEL1310110064#
reversible: false
is: SBO:0000176
name: RE2677
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_e3a2eaae_f526_4f69_a774_c39b01dc7075
name: GAMT
is: Q14353
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2593
type: Species
boundary condition: true
constant: false

metaM man e
name: D-Mannose
is: HMDB00169
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00159
boundary condition: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: CHEBI:16024

metaR r0627
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#

metaR r2356
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_6875198e_5953_4319_b870_c940e2fe331e
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: Q9BY49
initial concentration: NaN
name: PECR
is encoded by: hsa:55825

http://identifiers.org/biomodels.db/MODEL1310110064#_4821dde3_36ff_4e02_830b_c83d674095df
constant: false
name: SLC23A2
is: SBO:0000252
type: Species
is: Q9UGH3
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:9962
initial concentration: NaN

metaR RETNt
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
name: retinoic acid transport
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_245a3f7b_cf9e_42a7_ad02_e29857f6fb71
has only substance units: false
initial concentration: NaN
type: Species
is: Q53HE2
constant: false
is: SBO:0000252
name: TPI1
boundary condition: true
initial amount: NaN
is encoded by: hsa:7167

http://identifiers.org/biomodels.db/MODEL1310110064#_8227ee9b_cb9e_4fc1_aecc_89f7077c233a
is: SBO:0000252
name: _AI769281_1_e
is encoded by: hsa:AI769281
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaM cmp c
is: CHEBI:60377
is: HMDB00095
has only substance units: false
is: C00055
name: CMP
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
is: SBO:0000247

metaM co2 c
name: CO2
is: HMDB01967
is: CHEBI:3313
has only substance units: false
is: C00011
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: CO2 CHARGE: 0
is: SBO:0000247

metaM lnlnca r
is: HMDB01388
is: CHEBI:32387
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_47e3cbb5_344e_4b80_9275_298450bffcae
name: GAPDH
is encoded by: hsa:2597
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: E7EUT4
initial concentration: NaN
constant: false
type: Species

metaM cs b deg1 l
is: CHEBI:16953
is: SBO:0000247
type: Species
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: HMDB00812
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_93bebcbc_6c40_4486_a2c2_1db33183f7f1
is: P21953
has only substance units: false
name: BCKDHB
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:594

metaR CYTDK2m
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: false
fast: false
name: cytidine kinase (ATP), mitochondrial
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_27f3707e_5961_4d81_80d2_27336f5702dd
is: B3KUV7
is encoded by: hsa:5277
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: PIGA
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r2357
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110064#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000134
reversible: true
name: KHte
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_fd0e291b_a769_4428_81a1_d4b4605699db
constant: false
has only substance units: false
name: AUH
type: Species
initial amount: NaN
is: Q13825
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:549
boundary condition: true

metaM sph1p c
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial concentration: 1.0
boundary condition: false
is: CHEBI:57939
is: HMDB01383

metaM dcacoa m
initial concentration: 1.0
is: CHEBI:61430
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: HMDB06404
is: SBO:0000247
is: C05274

metaM dgchol c
constant: false
initial amount: NaN
name: glycochenodeoxycholate
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
is: HMDB00637
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:36252

metaM cs a deg5 l
constant: false
is: CHEBI:15936
boundary condition: false
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C23H36O24S CHARGE: -2

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM na1 e
constant: false
boundary condition: false
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
is: CHEBI:4541
type: Species
name: Sodium
is: C01330
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_667c762b_8a31_4a7e_a38f_4df11dd6cc68
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: _AI684467_1_m
is encoded by: hsa:AI684467

metaM cmp n
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:60377
is: SBO:0000247
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
name: CMP(2-)
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_8f9a6c9b_786d_4986_9e20_51163c4139fd
name: _AI539321_1_c
has only substance units: false
is encoded by: hsa:AI539321
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_fbe047ef_5ba5_4ec7_ac84_750e13bf584d
type: Species
is: SBO:0000252
is encoded by: hsa:728441
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: GGT2

metaM asp L m
is: HMDB00191
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:29991
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: L-aspartate(1-)

metaM arachdcrn r
is: SBO:0000247
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB06523
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57368
has only substance units: false
boundary condition: false
constant: false
name: C20:4 carnitine

metaM tyr L e
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
boundary condition: false
is: CHEBI:17895
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: L-tyrosine

http://identifiers.org/biomodels.db/MODEL1310110064#_e92c84c9_636e_418e_8fe7_ec3327951963
has only substance units: false
type: Species
initial concentration: NaN
name: PCBD1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5092
constant: false
is: P61457
initial amount: NaN

metaM sgalside hs c
name: sulfatide galactocerebroside
has only substance units: false
is: CHEBI:16523
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB03406
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_c685be83_7877_43af_a638_a82447be0237
name: SLC12A7
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is: Q9Y666
is encoded by: hsa:10723
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_9cf03d0d_8601_4b3a_976a_469435e4664e
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q86VV3
is: SBO:0000252
constant: false
name: ENTPD1
is encoded by: hsa:953

metaM etha c
is: HMDB00149
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
is: CHEBI:57603
name: etha[c]
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0

metaR PSSA1 hs
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.8.29
reactant: MODEL1310110064#
name: Phosphatidylserine synthase homo sapiens
fast: false
product: MODEL1310110064#
type: Reaction
reversible: true

metaR Ser Thrtg
name: Ser/Thr transport (from golgi to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110064#
is described by: ECO:0000269
product: MODEL1310110064#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110064#

metaM dpcoa m
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57328
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
initial concentration: 1.0
name: 3'-dephospho-CoA(2-)
is: HMDB01373

metaM leu L e
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
is: HMDB00687
name: L-leucine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15603
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_eb24a094_509a_4f45_937a_2bc8f2c964a8
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:3074
initial amount: NaN
is: P07686
is: SBO:0000252
name: HEXB
has only substance units: false
boundary condition: true

metaR 3AIBt
kinetic law: MODEL1310110064#
reversible: false
fast: false
name: 3-amino-isobutyrate transport
is: SBO:0000185
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
reactant: MODEL1310110064#
is described by: ECO:0000000

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaM 6thf e
is: http://identifiers.org/pubchem.compound/169691
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
name: hexaglutamyl folate (THF)
has only substance units: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1

metaR PGCD
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.95
product: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
type: Reaction
name: phosphoglycerate dehydrogenase
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000269

metaR biomass reaction
reversible: false
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000134
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: biomass_reaction
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_3f3da1c7_a8f9_4930_bcd6_b9e41815653b
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AA278423
constant: false
name: _AA278423_1_m
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_5ccdacc7_a63d_4926_8c5b_ebd85346fd03
boundary condition: true
is: SBO:0000252
is encoded by: hsa:125
is: P00325
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ADH1B
constant: false
type: Species

metaM co2 m
is: C00011
initial amount: NaN
is: HMDB01967
is: SBO:0000247
name: CO2
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
constant: false
boundary condition: false

metaM cmp m
name: CMP(2-)
initial amount: NaN
is: CHEBI:60377
is: SBO:0000247
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false

metaM sarcs c
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0
is: CHEBI:3513
name: Sarcosine
type: Species
initial concentration: 1.0
constant: false
is: C00213
initial amount: NaN
has only substance units: false
is: HMDB00271
is: SBO:0000247

metaR LALDO
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
is: SBO:0000176
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

http://identifiers.org/biomodels.db/MODEL1310110064#_335df301_9acd_4257_982c_d38716a3dafd
name: CA9
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:768
initial amount: NaN
is: SBO:0000252
is: Q16790

metaR r0295
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
fast: false
product: MODEL1310110064#
reversible: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_e6412839_b15c_4464_9604_8d5b2e032225
type: Species
constant: false
is: G5E960
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:5331
name: PLCB3

http://identifiers.org/biomodels.db/MODEL1310110064#_10f1aede_cee2_45fa_8fd1_75d10136c3a8
is: SBO:0000252
type: Species
has only substance units: false
name: _AA977580_1_c
is encoded by: hsa:AA977580
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_029596fd_7519_4502_9993_fc4d3731d143
type: Species
initial amount: NaN
boundary condition: true
name: _AI697028_1_m
initial concentration: NaN
is encoded by: hsa:AI697028
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_46e074b7_22d5_49a3_9e4a_22dddd56dc7a
name: OXSM
is encoded by: hsa:54995
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9NWU1
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM cl e
name: Chloride
boundary condition: false
is: C00115
is: HMDB00492
initial amount: NaN
type: Species
notes: FORMULA: Cl CHARGE: -1
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:3966

metaR r0145
type: Reaction
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
fast: false
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.8.3.1

metaR DOLPMT3 Uer
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.260
fast: false
is: SBO:0000176
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction

metaM succ m
is: CHEBI:30031
initial amount: NaN
is: HMDB00254
constant: false
name: Succinate
type: Species
initial concentration: 1.0
is: C00042
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false

metaM coa c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:3312
name: Coenzyme A
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: C00010
boundary condition: false
is: HMDB01423
constant: false
type: Species

metaM pmtcoa r
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
is: HMDB01338
is: CHEBI:3454
is: C00154
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
has only substance units: false

metaR LPS3
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
name: lipase
fast: false
modifier: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.23
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM but c
is: SBO:0000247
is: HMDB00039
initial amount: NaN
name: butyrate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
boundary condition: false
is: CHEBI:17968
constant: false
type: Species

metaR r0142
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reactant: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110064#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
type: Reaction
product: MODEL1310110064#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_51537293_91bf_42ee_b17c_060dd6b0bee8
is encoded by: hsa:622
initial amount: NaN
name: BDH1
is: Q02338
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM HC01496 m
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
name: 2-Amino-3-oxoadipate
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28095

metaM leu L c
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine
initial concentration: 1.0
constant: false
is: HMDB00687
boundary condition: false
initial amount: NaN
is: CHEBI:15603

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR PTPATe
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110064#
name: PTPATe
product: MODEL1310110064#
reversible: true

metaM h2o x
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
name: H2O
has only substance units: false
boundary condition: false
is: CHEBI:15377
initial amount: NaN
is: HMDB02111
is: SBO:0000247
constant: false
type: Species
is: C00001

metaM tchola c
type: Species
constant: false
has only substance units: false
name: taurocholic acid
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: CHEBI:36257
is: HMDB00036
is: SBO:0000247
boundary condition: false

metaR RE3628M
name: RE3628
is described by: ECO:0000000
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
reactant: MODEL1310110064#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110064#

metaR r2439
product: MODEL1310110064#
is: SBO:0000185
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
reversible: false
reactant: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
kinetic law: MODEL1310110064#
type: Reaction
fast: false

metaR SUCOAS1m
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: Succinate--CoA ligase (GDP-forming)
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
modifier: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR r0842
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: true
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_e17e2d0c_6f99_482f_964c_15275c9dd91b
initial amount: NaN
constant: false
initial concentration: NaN
name: GLDC
is: SBO:0000252
is: P23378
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:2731

metaR P5CDm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
reactant: MODEL1310110064#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_7324f6b8_5342_4698_952f_fb1f72545131
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:570
name: BAAT
has only substance units: false
boundary condition: true
type: Species
is: Q14032
initial concentration: NaN

metaR RETI1
reversible: true
name: retinol isomerase (11-cis)
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110064#

metaM pser L c
is: HMDB01721
is: CHEBI:15811
initial concentration: 1.0
name: O-Phospho-L-serine
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621

http://identifiers.org/biomodels.db/MODEL1310110064#_6a816f2c_d6fe_49ce_81e3_1d95e215136e
is: A8K7W0
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: VNN2
is encoded by: hsa:8875
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_a3c4351d_a772_4cba_ad02_ccdcbd561fd1
name: EGFL8
is encoded by: hsa:80864
is: Q99944
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252

metaM ala D e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: CHEBI:15570
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: D-alanine
constant: false
is: HMDB01310

metaM hco3 c
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: C00288
constant: false
name: Bicarbonate
boundary condition: false

metaR r1639
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110064#_5dbff556_3285_4a8f_b611_b69187a62024
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8560
is: O15121
is: SBO:0000252
name: DEGS1
initial concentration: NaN
boundary condition: true

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR GALC
reactant: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.46
reversible: false
is: SBO:0000176
name: Galactocerebrosidase
fast: false
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (2581.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES:NJ

metaR Q10H2e
product: MODEL1310110064#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
name: transport of ubiquinol into lymph
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_488cac8f_31fa_4ca6_b665_4ab69a090da8
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:10768
type: Species
is: SBO:0000252
has only substance units: false
name: AHCYL1
is: O43865

metaM pro L e
name: L-proline
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:17203
has only substance units: false
is: HMDB00162

metaR r0074
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:

metaM but e
boundary condition: false
is: HMDB00039
initial amount: NaN
is: SBO:0000247
name: butyrate
is: CHEBI:17968
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246

metaM sgalside hs g
is: HMDB00061
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial concentration: 1.0
is: CHEBI:58343
name: sulfatide galactocerebroside
boundary condition: false
type: Species
constant: false

metaR ACCOALm
modifier: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.1
name: acetate-CoA ligase (AMP-forming)
is described by: ECO:0000304
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
type: Reaction
fast: false

metaM dad 2 c
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
constant: false
boundary condition: false
is: HMDB00101
has only substance units: false
name: 2-deoxyadenosine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17256
type: Species
initial amount: NaN

metaM h2o r
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
has only substance units: false
boundary condition: false
is: HMDB02111
is: SBO:0000247
is: C00001
type: Species
name: H2O
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c9b7afc4_4f58_4acf_b06e_57b430d90460
is: SBO:0000252
initial amount: NaN
name: _D87002_1_m
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:D87002

metaR ACGALtly
product: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
name: N-acetyl-galactosamine lysosomal efflux
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_a911644d_501d_4c13_8cf2_323d1292d7fa
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: _AI924226_1_m
is: SBO:0000252
constant: false
is encoded by: hsa:AI924226
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_78ae3e77_f410_4f7a_bec2_2987c778cb7e
has only substance units: false
constant: false
is: P22352
is encoded by: hsa:2878
initial amount: NaN
name: GPX3
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaM pep c
name: Phosphoenolpyruvate
is: CHEBI:18021
boundary condition: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: C00074
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00263
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM dcsptn1coa m
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205483
is: C16173
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB06513

metaM cs e deg6 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
notes: FORMULA: C31H48NO32S2 CHARGE: -3
constant: false
is: CHEBI:16953
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00812
boundary condition: false
type: Species

metaM gacpail hs r
name: glucosaminyl-acylphosphatidylinositol
is: HMDB00128
boundary condition: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
constant: false
type: Species
is: CHEBI:16344
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR KYNAKGAT
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110064#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.7
name: L-Kynurenine:2-oxoglutarate aminotransferase

metaR METS
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.1.1.13
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
name: methionine synthase

metaM m2emgacpail hs r
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:24636
is: C00080
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

metaR CYANt
kinetic law: MODEL1310110064#
name: Cyanide transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110064#
reversible: true
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM

metaM 4abutn m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-ammoniobutanal
is: CHEBI:58264
constant: false
initial amount: NaN
type: Species
is: HMDB01080

http://identifiers.org/biomodels.db/MODEL1310110064#_3dfe521b_df07_4926_a4a3_cbf302af0712
has only substance units: false
type: Species
name: _BC005314_1_x
is encoded by: hsa:BC005314
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaM h c
type: Species
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
is: C00080
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380

metaM hco3 e
name: Bicarbonate
has only substance units: false
is: CHEBI:17544
is: HMDB00595
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM lnlncg r
has only substance units: false
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB03073
is: CHEBI:32391
initial concentration: 1.0

metaR MI4PP
reactant: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 4-phosphatase
product: MODEL1310110064#
fast: false
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_65b052af_cbbd_436d_ac77_cc3ca8960871
is: SBO:0000252
has only substance units: false
is: P38571
type: Species
initial concentration: NaN
is encoded by: hsa:3988
boundary condition: true
initial amount: NaN
constant: false
name: LIPA

metaR RE1521M
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: RE1521
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM tyr L c
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
has only substance units: false
is: HMDB00158
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: L-tyrosine
is: CHEBI:17895
type: Species
initial amount: NaN

metaR NACHEX1ly
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal

metaR r2080
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110064#

metaM f6p c
name: D-Fructose 6-phosphate
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00124
boundary condition: false
is: C00085
is: http://identifiers.org/pubchem.compound/3385
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57579

metaM pro L c
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
has only substance units: false
is: CHEBI:17203
initial amount: NaN
is: SBO:0000247
is: HMDB00162
name: L-proline

metaR KDNH
product: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
name: 2-keto-3deoxy-D-glycero-D-galactononic acid phosphohydrolase
reversible: false

metaM b2coa m
constant: false
is: HMDB02009
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:57332
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
has only substance units: false
name: crotonoyl-CoA(4-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_3fe342b3_2dbb_492f_93ab_d4e014a9383d
boundary condition: true
constant: false
is encoded by: hsa:11227
initial amount: NaN
is: A5PKZ1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: GALNT5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_12ed8923_8c49_47a2_8242_643851f06cf5
has only substance units: false
name: DHCR24
boundary condition: true
is: SBO:0000252
is: Q15392
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:1718
initial concentration: NaN

metaM HC00342 m
name: cis-aconitate(3-)
is: CHEBI:16383
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
is: SBO:0000247

metaM mthgxl c
is: HMDB01167
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial amount: NaN
initial concentration: 1.0
name: methylglyoxal
is: CHEBI:17158
boundary condition: false
has only substance units: false

metaM udpg r
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: CHEBI:58367
is: SBO:0000247
is: HMDB00286
initial amount: NaN
has only substance units: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_6b538e68_e369_42a6_8b37_0a3c0aa37e49
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: Q9UBM7
initial amount: NaN
has only substance units: false
is encoded by: hsa:1717
name: DHCR7
type: Species

metaM arachdcrn m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: C20:4 carnitine
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
is: HMDB01322
is: CHEBI:57387
constant: false

metaM xol25oh r
boundary condition: false
is: CHEBI:42977
has only substance units: false
constant: false
is: HMDB06247
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
initial concentration: 1.0
name: 25-hydroxycholesterol
initial amount: NaN
type: Species

metaR INSTt4
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
name: inositol transport via sodium symport
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR DURAD
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110064#
name: dihydrouracil dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.3.1.2
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_249d9502_71d5_41d7_8f2e_b548493acabb
is encoded by: hsa:4710
type: Species
boundary condition: true
is: O95168
initial amount: NaN
name: NDUFB4
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaR MMSAD1m
reactant: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
name: methylmalonate-semialdehyde dehydrogenase
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.27
fast: false
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_19fd3cbb_a903_4feb_9c51_9c1c9c4e1abd
type: Species
constant: false
is encoded by: hsa:2544
initial amount: NaN
name: _2544_1_c
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_10f0545a_b659_4541_a66e_ea77fc795fcf
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: LYZL1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84569
is: Q6UWQ5
constant: false

metaR C204CPT2
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
type: Reaction
name: arachidonic acid transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
product: MODEL1310110064#

metaM 2mop c
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
is: HMDB01172
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_7f72cd32_f222_45c0_983c_a3450c03bbb7
type: Species
name: SLC1A3
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q7Z5T0
is encoded by: hsa:6507
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_28e38c16_e0ee_49d1_9620_c98b953fe2cf
has only substance units: false
is: SBO:0000252
is encoded by: hsa:28232
is: Q9UIG8
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: SLCO3A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d0cdca64_ef4f_4a48_8701_451f8cff5254
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: Q8NCL4
is encoded by: hsa:11226
initial amount: NaN
name: GALNT6
has only substance units: false

metaR r0845
product: MODEL1310110064#
reversible: false
type: Reaction
kinetic law: MODEL1310110064#
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment

metaR BILIRED
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110064#
fast: false
name: Nad(p)h biliverdin reductase
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.1.24
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110064#_5832e64a_272a_48ec_a880_ef30d0b1cd26
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: A8K596
is encoded by: hsa:1757
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SARDH

metaM h e
type: Species
is: SBO:0000247
is: C00080
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380

metaM HC02179 c
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
is: SBO:0000247
type: Species

metaR r1634
reversible: true
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r1669
reversible: true
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#

metaR CYTDt
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110064#
name: cytidine facilated transport in cytosol
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false

metaR NDPK7n
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM dtdp e
initial amount: NaN
is: CHEBI:58369
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
is: HMDB01274
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false

metaR r1455
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
name: Transport reaction
reversible: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_8e6b3b0d_16fd_48db_ba60_7e45c417b23d
initial concentration: NaN
is encoded by: hsa:427
is: SBO:0000252
is: Q96AS2
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: ASAH1

metaM dpcoa e
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
initial amount: NaN
initial concentration: 1.0
name: Dephospho-CoA
is: SBO:0000247
is: C00882
is: HMDB01373
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:57328
type: Species

metaM asp L e
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191
boundary condition: false
constant: false
is: CHEBI:29991
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: L-aspartate(1-)

metaR NAIt
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
is: SBO:0000185
name: Na+ / iodide cotransport
type: Reaction
reversible: true
kinetic law: MODEL1310110064#
is described by: ECO:0000269
reactant: MODEL1310110064#
fast: false
modifier: MODEL1310110064#

metaM succ c
type: Species
is: HMDB00254
constant: false
name: Succinate
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30031
has only substance units: false

metaR r0558
fast: false
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
modifier: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110064#

metaR r0780
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR CYTK6n
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110064#
name: cytidylate kinase (CMP,CTP),nuclear
type: Reaction
fast: false
reversible: true
is: SBO:0000176

metaM h2o n
is: HMDB02111
is: CHEBI:15377
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial amount: NaN
name: water

metaR EX 25hvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D3 exchange
type: Reaction

metaR FAOXC183806m
fast: false
reversible: false
name: Beta oxidation of fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM HC01842 c
is: CHEBI:31997
boundary condition: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: Phosphodimethylethanolamine

metaR ILETA
is: SBO:0000176
modifier: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
type: Reaction
reactant: MODEL1310110064#
name: isoleucine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
is described by: ECO:0000269

metaM r1p c
initial concentration: 1.0
constant: false
is: HMDB01489
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
has only substance units: false
type: Species
boundary condition: false
name: alpha-D-Ribose 1-phosphate
is: SBO:0000247
is: C00442
is: CHEBI:57720
initial amount: NaN

metaR DASCBR
is version of: http://identifiers.org/ec-code/1.8.4.1
is described by: ECO:0000269
product: MODEL1310110064#
modifier: MODEL1310110064#
name: dehydroascorbate reductase
fast: false
reversible: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
kinetic law: MODEL1310110064#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_0c0270d3_ce36_4d44_b1a0_3f031b623d86
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
name: UROD
is: SBO:0000252
is: P06132
initial concentration: NaN
is encoded by: hsa:7389

http://identifiers.org/biomodels.db/MODEL1310110064#_165b8a20_1ef1_4f3f_a8b0_3208306c9981
type: Species
has only substance units: false
initial concentration: NaN
is: P21912
is: SBO:0000252
constant: false
boundary condition: true
name: SDHB
is encoded by: hsa:6390
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_2b68d7d9_ef76_4e0e_9fcd_16596a0598f6
type: Species
is: Q38G75
has only substance units: false
is encoded by: hsa:2582
name: GALE
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r0559
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110064#
fast: false
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
modifier: MODEL1310110064#
type: Reaction
is: SBO:0000176

metaR r1456
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
name: Transport reaction
reversible: false
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_3bd6d639_dc66_454e_94d6_dce076b2600a
has only substance units: false
type: Species
constant: false
is: P00918
is: SBO:0000252
is encoded by: hsa:760
initial amount: NaN
boundary condition: true
name: CA2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_5de3030b_934b_419c_ba9f_c09c4830692a
type: Species
name: VNN3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55350
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_88732815_556a_402f_ac82_2775b4f6a855
is encoded by: hsa:4696
has only substance units: false
initial amount: NaN
constant: false
name: NDUFA3
is: SBO:0000252
boundary condition: true
is: O95167
initial concentration: NaN
type: Species

metaR ADK1
name: adenylate kinase
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110064#
is described by: ECO:0000269
reactant: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110064#

metaM h g
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
name: proton
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:24636
has only substance units: false

metaR MANt4
kinetic law: MODEL1310110064#
name: D-mannose transport via sodium cotransport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110064#
type: Reaction
is: SBO:0000185

metaM arachd r
has only substance units: false
name: arachidonate
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
type: Species
initial concentration: 1.0
is: HMDB01043
initial amount: NaN
is: CHEBI:32395
boundary condition: false

metaM sgalside hs l
type: Species
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:16349
constant: false
boundary condition: false
name: sulfatide galactocerebroside
has only substance units: false
is: SBO:0000247
is: HMDB00904
initial concentration: 1.0
initial amount: NaN

metaM h2o m
is: CHEBI:15377
name: H2O
is: SBO:0000247
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB02111
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_59078ea7_9783_43dc_b4f1_361b83da9390
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:51109
name: RDH11
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: B4DDW0

metaR XYLt
kinetic law: MODEL1310110064#
is described by: ECO:0000269
name: D-xylose reversible transport
reactant: MODEL1310110064#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
fast: false
is: SBO:0000185
product: MODEL1310110064#
modifier: MODEL1310110064#

metaM dolmanp U r
is: CHEBI:15809
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human uterine homolog
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR CYTK13n
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dATP),nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#
product: MODEL1310110064#

metaR CO2t
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000185
product: MODEL1310110064#
reversible: true
is described by: ECO:0000000
name: CO2 transporter via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
reactant: MODEL1310110064#

metaM din c
is: HMDB00071
is: C05512
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:28997
is: SBO:0000247
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
constant: false
has only substance units: false
name: Deoxyinosine
type: Species

metaR r1632
modifier: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false

metaM dad 2 e
initial amount: NaN
name: 2-deoxyadenosine
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00101
initial concentration: 1.0
is: CHEBI:17256
has only substance units: false
constant: false

metaR r1453
product: MODEL1310110064#
is: SBO:0000176
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#

metaR r1667
reversible: true
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#

metaM HC02179 e
is: SBO:0000247
has only substance units: false
name: 20-hydroxy-arachidonate
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false

metaM dhdascb c
is: CHEBI:58070
has only substance units: false
initial amount: NaN
name: dehydroascorbide(1-)
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
boundary condition: false
constant: false
is: HMDB01264
initial concentration: 1.0
type: Species

metaM succ e
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: succinate(2-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:30031
is: HMDB00254
type: Species
constant: false

metaM dtdp c
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00363
is: HMDB01274
name: dTDP
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaM dpcoa c
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
initial amount: NaN
is: C00882
has only substance units: false
is: HMDB01373
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57328
type: Species
name: Dephospho-CoA

metaR HISCAT1
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR r2142
type: Reaction
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM betald c
initial concentration: 1.0
is: SBO:0000247
is: HMDB01252
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:15710
name: betaine aldehyde
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576

http://identifiers.org/biomodels.db/MODEL1310110064#_c5362323_d735_4b3e_b1e9_f5456f66d300
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR ADSS
type: Reaction
name: adenylosuccinate synthase
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
product: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reactant: MODEL1310110064#
fast: false
is: SBO:0000176

metaR r1454
fast: false
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:

metaR r1631
is: SBO:0000185
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110064#

metaR r1668
is: SBO:0000185
reversible: true
name: Y+LAT2 Utilized transport
product: MODEL1310110064#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_29f2c76e_4520_49f1_89e7_13ce096479ba
initial concentration: NaN
name: _286297_1_c
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:286297
boundary condition: true
constant: false
has only substance units: false

metaM CE0849 m
is: SBO:0000247
name: cis,cis-palmito-7,10-dienoyl-CoA
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
type: Species
boundary condition: false
constant: false
is: CHEBI:57795
has only substance units: false
initial concentration: 1.0

metaR r0783
product: MODEL1310110064#
reactant: MODEL1310110064#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is: SBO:0000176

metaR ADK3
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adentylate kinase (GTP)
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
fast: false
is: SBO:0000176

metaM Lcystin e
initial concentration: 1.0
initial amount: NaN
name: L-cystine
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:16283
is: HMDB00192

metaR DNDPt27m
reactant: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
reversible: false
name: dCDP transport via dTDP antiport
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR GUMTCHOLe
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM din e
is: HMDB00071
name: Deoxyinosine
is: C05512
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:28997
constant: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
type: Species
has only substance units: false

metaR NDPK10
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110064#
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:dIDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_0286151f_7989_4c2f_a853_faaee01b4e72
is: P14550
initial concentration: NaN
constant: false
is encoded by: hsa:10327
initial amount: NaN
name: AKR1A1
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM leuktrE4 c
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
is: CHEBI:57462
initial amount: NaN
type: Species
is: HMDB02200
name: leukotriene E4(1-)
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

metaM uri e
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16704
is: C00299
is: SBO:0000247
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
name: Uridine
is: HMDB00296
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_998e1f27_5120_466c_9ca3_f83a0e618e1f
initial concentration: NaN
type: Species
name: NDUFB10
is: SBO:0000252
is encoded by: hsa:4716
initial amount: NaN
boundary condition: true
is: A8K761
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_99725c2c_bdef_4178_a61d_50fa7d170c3a
type: Species
initial amount: NaN
is: O14561
is encoded by: hsa:4706
has only substance units: false
name: NDUFAB1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaM acald m
name: acetaldehyde
is: HMDB00990
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
is: CHEBI:15343
is: SBO:0000247

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR r1638
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM sbt D e
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
name: D-glucitol
boundary condition: false
is: HMDB00247
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_79e7b22c_3a4b_4836_9f45_402830eee4df
name: DLD:DLST:OGDH:PDHX
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1738
has part: P09622
is encoded by: hsa:1743
has part: P36957
is: SBO:0000297
has part: O00330
constant: false
is encoded by: hsa:4967
boundary condition: true
is encoded by: hsa:8050
has part: Q02218

metaR r1459
type: Reaction
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
name: Transport reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
reversible: true

metaR PLA2 2
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
name: phospholipase A2
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
reversible: false
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.4

http://identifiers.org/biomodels.db/MODEL1310110064#_185e5a1b_cc75_4d4d_b5e7_16e153c58da5
initial concentration: NaN
name: NDUFS2
boundary condition: true
is encoded by: hsa:4720
has only substance units: false
is: B7Z792
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR LYStip
is: SBO:0000185
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: L-lysine transport, peroxisomal (irreversible)
is described by: ECO:0000000
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM

metaR PIt8
product: MODEL1310110064#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110064#
is described by: ECO:0000006
modifier: MODEL1310110064#
name: phosphate transport in/out via Na+ symporter
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
type: Reaction
reactant: MODEL1310110064#
reversible: true

metaR r2140
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110064#
type: Reaction

metaR TYRTA
is: SBO:0000176
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110064#
fast: false

metaM pmtcoa x
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
is: C00154
initial concentration: 1.0

metaM glyclt x
is: CHEBI:29805
has only substance units: false
is: HMDB00115
constant: false
is: SBO:0000247
name: glycolate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_6205479e_8344_420b_bcd8_bee25a8c10dd
boundary condition: true
is: P17568
initial amount: NaN
name: NDUFB7
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:4713
is: SBO:0000252

metaR SERDGLYexR
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: true
name: D-Serine/Glycine reversible exchange

metaR RE3524R
type: Reaction
fast: false
reactant: MODEL1310110064#
reversible: true
is: SBO:0000176
product: MODEL1310110064#
is described by: ECO:0000000
name: RE3524
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
kinetic law: MODEL1310110064#

metaR DADAe
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is described by: ECO:0000269
kinetic law: MODEL1310110064#
name: Deoxyadenosine deaminase, extracellular
type: Reaction
fast: false
modifier: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.5.4.4
reversible: false

metaM lpchol hs c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:60479
name: lysophosphatidylcholine
type: Species
initial amount: NaN
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0

metaR r1637
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM ala D c
constant: false
has only substance units: false
type: Species
is: CHEBI:15570
is: HMDB01310
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine
initial amount: NaN

metaM glyc R m
initial concentration: 1.0
name: D-glycerate
is: CHEBI:16659
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false
is: HMDB00139
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_ea4295fb_c280_4ab9_bda6_fca51c10af8a
name: QDPR
initial amount: NaN
is: P09417
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5860

metaR r0149
is version of: http://identifiers.org/ec-code/1.14.13.39
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
product: MODEL1310110064#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
modifier: MODEL1310110064#
type: Reaction

metaM HC02206 c
type: Species
name: prostaglandin C1(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: SBO:0000247
is: CHEBI:57399
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaM uri c
constant: false
type: Species
is: SBO:0000247
has only substance units: false
name: Uridine
is: C00299
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
initial concentration: 1.0
is: HMDB00296
is: CHEBI:16704
boundary condition: false

metaM 2mop m
is: SBO:0000247
initial concentration: 1.0
name: 2-methyl-3-oxopropanoate
has only substance units: false
is: HMDB01172
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
is: CHEBI:57700
boundary condition: false
constant: false

metaR r2141
is: SBO:0000185
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
fast: false
product: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_9b0c2150_ba05_4782_91ce_85cc0ea3c439
has only substance units: false
type: Species
is encoded by: hsa:9498
is: SBO:0000252
name: SLC4A8
boundary condition: true
is: E7EML0
initial concentration: NaN
constant: false
initial amount: NaN

metaM xu5p D c
name: D-xylulose 5-phosphate(2-)
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00868
initial concentration: 1.0
is: CHEBI:57737
is: SBO:0000247
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209

http://identifiers.org/biomodels.db/MODEL1310110064#_23b3f38f_a21d_404c_9c9e_b47e311b5901
constant: false
is encoded by: hsa:6715
is: SBO:0000252
is: P18405
initial concentration: NaN
name: SRD5A1
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_f82971af_953d_4dd0_93d5_b787a4698c78
is: P28329
constant: false
name: CHAT
type: Species
is encoded by: hsa:1103
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR DURIK1
modifier: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000254
reactant: MODEL1310110064#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.21
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
name: deoxyuridine kinase (ATP:Deoxyuridine)
is: SBO:0000176
kinetic law: MODEL1310110064#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_9fc6056b_24ca_46f1_906e_e81bd24a39ca
is: SBO:0000252
name: ACP2
type: Species
is encoded by: hsa:53
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: E9PCI1

metaM HC01406 m
boundary condition: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: 3-Oxooctanoyl-CoA
is: CHEBI:28264

http://identifiers.org/biomodels.db/MODEL1310110064#_6080b92a_8a43_47ad_bee6_1ab2059de7cd
constant: false
initial amount: NaN
is: SBO:0000252
name: ECHS1
initial concentration: NaN
boundary condition: true
type: Species
is: P30084
has only substance units: false
is encoded by: hsa:1892

http://identifiers.org/biomodels.db/MODEL1310110064#_aecf99e6_3cdd_40b7_9653_4378b83ae1aa
initial amount: NaN
has only substance units: false
is: SBO:0000297
constant: false
initial concentration: NaN
boundary condition: true
has part: Q9UPY5
type: Species
name: SLC7A11:SLC3A2
is encoded by: hsa:23657

metaR r0556
kinetic law: MODEL1310110064#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176

metaM h l
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
name: proton
type: Species
has only substance units: false
is: CHEBI:24636

metaR r1636
kinetic law: MODEL1310110064#
type: Reaction
reversible: true
modifier: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM pre prot r
is: CHEBI:16240
type: Species
is: HMDB03125
initial amount: NaN
name: glycophosphatidylinositol (GPI)-anchored protein precursor
initial concentration: 1.0
boundary condition: false
notes: FORMULA: XY CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_eede4a0a_1748_4f4e_bb59_78cd62b49711
constant: false
type: Species
is: Q6IRT1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:128
initial amount: NaN
is: SBO:0000252
name: ADH5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_9a452b03_1d78_4e82_91e7_68b60c768211
type: Species
name: NME6
boundary condition: true
has only substance units: false
is: O75414
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10201
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c28fb30d_efa4_4050_8a35_2dcb5ce6a4af
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: P31040
is encoded by: hsa:6389
boundary condition: true
initial amount: NaN
name: SDHA
is: SBO:0000252

metaM h2o l
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB02111
is: CHEBI:15377
name: water
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN

metaR CYSGLTH
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reversible: true
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
name: Glutathione:cystine oxidoreductase
fast: false

metaR DNDPt12m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
kinetic law: MODEL1310110064#
name: dADP transport via ADP antiport
modifier: MODEL1310110064#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000269
product: MODEL1310110064#

metaM cdpdag hs c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
constant: false
name: CDP-diacylglycerol(2-)
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:58332

http://identifiers.org/biomodels.db/MODEL1310110064#_1e2aad6c_01e1_4e44_8451_93cebd787eb1
has only substance units: false
initial amount: NaN
type: Species
has part: Q8TEQ8
has part: Q07326
constant: false
is encoded by: hsa:84720
is: SBO:0000297
name: PIGF:PIGO
is encoded by: hsa:5281
boundary condition: true
initial concentration: NaN

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM acgal1p c
boundary condition: false
is: HMDB06480
has only substance units: false
is: SBO:0000247
is: CHEBI:55404
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
initial amount: NaN
initial concentration: 1.0
name: N-Acetyl-D-galactosamine 1-phosphate
constant: false
type: Species

metaM lpchol hs e
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:60479
initial amount: NaN
boundary condition: false
type: Species
name: lysophosphatidylcholine
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: SBO:0000247

metaM h m
is: CHEBI:24636
has only substance units: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false

metaM HC02206 e
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: prostaglandin C1(1-)
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: CHEBI:57399

http://identifiers.org/biomodels.db/MODEL1310110064#_45f77cb5_9b8b_44fb_9024_4f22d55ed1c5
initial amount: NaN
is: Q99707
constant: false
has only substance units: false
is encoded by: hsa:4548
type: Species
name: MTR
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR PIt7
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
name: phosphate transport in/out via three Na+ symporter
product: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT

metaR UMPK3n
modifier: MODEL1310110064#
name: UMP kinase (UTP),nuclear
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110064#_a25a13bf_a4af_4871_9bff_9603bb0b22e2
boundary condition: true
is encoded by: hsa:3158
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P54868
name: HMGCS2
type: Species
initial concentration: NaN

metaR r1635
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110064#

metaM cl c
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
initial amount: NaN
is: CHEBI:3966
is: C00115
is: HMDB00492
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: Chloride

http://identifiers.org/biomodels.db/MODEL1310110064#_99e1a45d_599a_4b41_9c47_18a9fd168601
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: _T83654_1_c
is encoded by: hsa:T83654
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_47f8c42f_eaed_498d_8a7a_69326b4c7ec5
is: Q5JPA4
constant: false
is encoded by: hsa:53919
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: SLCO1C1
has only substance units: false
boundary condition: true

metaR DPCOAPPe
name: Pyrophasphatase (dephospho-CoA, extracellular)
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reversible: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:

metaM cs c deg5 l
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C23H36O24S CHARGE: -2
boundary condition: false
is: SBO:0000247
is: CHEBI:15936
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_4e9250a7_a323_44c2_b87a_8d34802ce175
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: SLC7A5
initial concentration: NaN
constant: false
is: Q8IV97
is encoded by: hsa:8140
initial amount: NaN

metaM crn c
is: CHEBI:16347
is: C00318
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00062
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: L-Carnitine
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

http://identifiers.org/biomodels.db/MODEL1310110064#_4d30182f_d56e_441f_8b16_4d8128250bdc
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:PRO1933
initial amount: NaN
is: SBO:0000252
name: _PRO1933_1_m
has only substance units: false
boundary condition: true

metaR r0999
type: Reaction
reversible: true
name: Facilitated diffusion
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110064#
is: SBO:0000185

metaM coa x
type: Species
has only substance units: false
is: HMDB01423
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: C00010
initial concentration: 1.0
constant: false
is: CHEBI:57287

metaM q10h2 m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Ubiquinol-10
initial amount: NaN
constant: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_68e10685_f8c2_42b9_8be3_b8c050b3b935
is: Q6NSB3
name: AMY1A
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:276
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaR r0426
type: Reaction
fast: false
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.34
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is: SBO:0000176
product: MODEL1310110064#

metaM retinal r
constant: false
is: CHEBI:15035
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01358
boundary condition: false
type: Species
name: retinal

metaR DNADtn
name: dNAD transport, nuclear trhough pore
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
reactant: MODEL1310110064#
reversible: true
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR r2511
type: Reaction
name: Utilized transport
is: SBO:0000185
product: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000

metaR RE3326M
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110064#
name: RE3326
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.4

metaR DHCRD1
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: dihydroceramide desaturase
fast: false
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ

metaM xyl D l
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:15936
name: aldehydo-D-xylose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_e4b069c3_64e8_44cb_888c_e9dedea691e2
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:7296
constant: false
initial amount: NaN
name: TXNRD1

metaR FACOAL203
is described by: ECO:0000000
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reversible: true
type: Reaction
name: fatty-acid--CoA ligase
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110064#

metaM prpncoa m
initial concentration: 1.0
is: CHEBI:57367
type: Species
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
boundary condition: false
is: HMDB02307
has only substance units: false
name: acryloyl-CoA(4-)
constant: false
is: SBO:0000247
initial amount: NaN

metaR NADtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#
type: Reaction
name: transport of NAD into peroxisome
product: MODEL1310110064#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_68f46258_b74a_4768_83cc_101cf84f8e64
initial amount: NaN
type: Species
is encoded by: hsa:125965
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: COX6B2
boundary condition: true
is: Q6YFQ2

metaM ocdcea c
is: C00712
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00207
has only substance units: false
constant: false
is: CHEBI:0
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_748c9df6_1267_4bdb_9d1c_f85623a78f65
name: DEGS1
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:8560
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM chsterol l
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: cholesterol
is: HMDB00067
is: CHEBI:16113
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaM HC02207 c
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:27555
boundary condition: false
type: Species

metaR r0998
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: true
product: MODEL1310110064#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction

metaM tcynt c
is: CHEBI:18022
initial amount: NaN
name: thiocyanate
type: Species
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
boundary condition: false
constant: false
is: HMDB01453
initial concentration: 1.0

metaM 3hpcoa m
boundary condition: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
initial amount: NaN
name: 3-hydroxypropanoyl-CoA(4-)
is: HMDB06807
has only substance units: false
is: CHEBI:58528
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_2f4b577a_9d82_4d6b_ab5c_7a44a0d161e0
has only substance units: false
is encoded by: hsa:AI640625
initial concentration: NaN
boundary condition: true
constant: false
name: _AI640625_1_c
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_16151594_1352_4e01_9cbd_6373a5158af3
constant: false
boundary condition: true
has only substance units: false
name: ATG9B
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q674R7
is encoded by: hsa:285973
type: Species

metaM cspg c e
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00106
initial concentration: 1.0
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: HMDB00300
initial amount: NaN
is: CHEBI:17568
type: Species
constant: false

metaR CSCPASEly
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
name: chondroitin sulfate C proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000

metaR SRTNtu
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110064#
is: SBO:0000185
reversible: true
name: Serotonin uniport
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
is described by: ECO:0000269

metaM HC01610 e
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
boundary condition: false
initial concentration: 1.0
is: CHEBI:28607
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: CoproporphyrinogenI
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_3e2962ae_271b_4cac_8514_8674cf227ae3
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:117248
name: GALNTL2
is: SBO:0000252
is: Q8N3T1
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_b8516931_7224_4a42_84d6_df58ea16e920
boundary condition: true
is: SBO:0000252
is: Q5SYN6
type: Species
constant: false
is encoded by: hsa:6581
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SLC22A3

http://identifiers.org/biomodels.db/MODEL1310110064#_41ea5257_e19b_4b2a_9872_f49c2bd50e74
type: Species
name: CYP27A1
constant: false
is: Q02318
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1593
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM tdcoa m
type: Species
has only substance units: false
is: CHEBI:57385
constant: false
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: C02593
is: SBO:0000247
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_ab848e24_0060_403b_a199_5bed01103c04
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2590
initial amount: NaN
name: GALNT2
constant: false
is: Q10471
initial concentration: NaN
has only substance units: false
type: Species

metaM mescon m
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00749
type: Species
name: Mesaconate
is: CHEBI:36986

http://identifiers.org/biomodels.db/MODEL1310110064#_6b9e0b4f_5698_47c6_b4ac_c1605e307251
boundary condition: true
is: Q06830
is encoded by: hsa:5052
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: PRDX1

metaM tchola x
is: CHEBI:36257
initial amount: NaN
type: Species
name: taurocholate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00036
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122

metaM ach n
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
has only substance units: false
is: SBO:0000247
type: Species
name: acetylcholine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_5250f425_aa6d_4a55_a7e6_8e6163b17b83
constant: false
is encoded by: hsa:10400
name: PEMT
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9UBM1
initial amount: NaN
has only substance units: false

metaM ptth c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:16753
is: HMDB03426
name: pantetheine
is: SBO:0000247
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false

metaM creat e
type: Species
has only substance units: false
is: HMDB00064
is: SBO:0000247
initial concentration: 1.0
name: creatine
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919

metaR RE3421R
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reversible: true
product: MODEL1310110064#
type: Reaction
name: RE3421
is: SBO:0000176
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000

metaM fum m
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
initial concentration: 1.0
is: HMDB00134
boundary condition: false
is: CHEBI:29806

metaM 20ahchsterol m
constant: false
is: CHEBI:1296
boundary condition: false
is: SBO:0000247
name: 20-hydroxycholesterol
is: HMDB06283
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500

metaM oaa m
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16452
type: Species
name: Oxaloacetate
is: C00036
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: HMDB00223
is: SBO:0000247
initial amount: NaN

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27555
has only substance units: false
type: Species
boundary condition: false
constant: false

metaM HC00460 c
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
name: 2,5-dihydroxybenzoate
type: Species
initial concentration: 1.0
is: CHEBI:58044
is: SBO:0000247
has only substance units: false

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaR LNLCCRNt
modifier: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110064#
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110064#

metaM orot c
is: HMDB00226
has only substance units: false
type: Species
boundary condition: false
name: Orotate
constant: false
is: CHEBI:30839
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: C00295
is: SBO:0000247

metaR r0267
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
reactant: MODEL1310110064#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.5.1.9
kinetic law: MODEL1310110064#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is described by: ECO:0000000
modifier: MODEL1310110064#
is: SBO:0000176
type: Reaction
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_3d10b393_d914_4526_ba15_a62a80f7dce7
is encoded by: hsa:23632
type: Species
has only substance units: false
constant: false
name: CA14
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: A8K3J4
initial concentration: NaN

metaR MCLOR
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: 3-Mercaptolactate:NAD+ oxidoreductase
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
fast: false
product: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
modifier: MODEL1310110064#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_704a38f6_bf8e_49bc_ae71_d63d566f13f3
has only substance units: false
is: P20674
type: Species
initial amount: NaN
name: COX5A
is encoded by: hsa:9377
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_25ff0963_6da3_4353_ba19_5d4167117d0d
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _AA664770_1_m
initial amount: NaN
constant: false
is encoded by: hsa:AA664770
type: Species

metaM galside hs l
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
boundary condition: false
is: CHEBI:12947
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247

metaR r0908
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
name: Postulated transport reaction
product: MODEL1310110064#

metaM adn c
name: Adenosine
is: SBO:0000247
is: C00212
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16335
is: HMDB00050
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false
type: Species
constant: false

metaM gthrd e
initial amount: NaN
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
is: CHEBI:57925
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00125
initial concentration: 1.0
name: glutathionate(1-)

http://identifiers.org/biomodels.db/MODEL1310110064#_9bd4c51e_3032_45ff_90f9_eb4a4510e877
is encoded by: hsa:51251
initial amount: NaN
is: SBO:0000252
constant: false
name: NT5C3
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: Q9H0P0

metaR CITRtm
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
type: Reaction
name: citrulline mitochondrial transport via proton antiport
modifier: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_c6401340_6899_459e_8d62_19f964e9926c
type: Species
is encoded by: hsa:6535
is: B4DIA3
boundary condition: true
is: SBO:0000252
constant: false
name: SLC6A8
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r1993
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reversible: false
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
type: Reaction

metaM 56dura c
has only substance units: false
constant: false
is: CHEBI:15901
initial amount: NaN
boundary condition: false
name: 5,6-dihydrouracil
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: HMDB00076

metaM mag hs c
boundary condition: false
constant: false
type: Species
is: HMDB12130
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16987
has only substance units: false
is: SBO:0000247
name: monoacylglycerol 2

metaR EX 23cump LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2',3'-cyclic UMP(1-) exchange
type: Reaction

metaR r1527
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.1
modifier: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#

metaM accoa c
boundary condition: false
initial concentration: 1.0
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00024
constant: false
is: HMDB01206
is: CHEBI:57288

metaR FE2tm
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
name: iron (II) transport

metaR r0268
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
kinetic law: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1

metaR INSt4
name: inosine transport in via sodium symport
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9153.1) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_33ef34af_21df_4e88_8609_7ec225c1c27c
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:18
has only substance units: false
name: ABAT
initial amount: NaN
is: P80404
initial concentration: NaN

metaR RE1526M
fast: false
name: RE1526
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
reversible: true

metaR DTTPtn
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dTTP diffusion in nucleus
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
fast: false

metaR SUCCtp
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
reversible: true
name: succinate transporter, peroxisome
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000185
product: MODEL1310110064#

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM creat c
is: CHEBI:16919
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: creatine
boundary condition: false
is: HMDB00064
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_e0cc02cd_b6e0_4b50_b35f_54961989ede9
name: SLC22A2
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6582
is: O15244
has only substance units: false
constant: false

metaR r0909
is described by: ECO:0000000
name: Transport reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_969ba78b_dbf5_46ac_9139_7ec29237c9b9
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: _AU149534_1_e
is encoded by: hsa:AU149534
initial amount: NaN
constant: false

metaM mal L m
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:15589
is: SBO:0000247
type: Species
is: HMDB00156
name: (S)-malate(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_ec0049c6_afdd_400d_8145_2ff97d210244
has only substance units: false
is: P46926
is encoded by: hsa:10007
name: GNPDA1
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM gly m
is: CHEBI:15428
is: HMDB00123
name: Glycine
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: C00037
initial amount: NaN

metaR ACCOAC
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_0cf82445_bfba_4c13_a5d5_462760c03d44
constant: false
boundary condition: true
name: PIGC
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5279
is: SBO:0000252

metaM orot e
has only substance units: false
is: HMDB00226
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:30839
name: orotate

http://identifiers.org/biomodels.db/MODEL1310110064#_dfaaf89f_a108_455b_bfdc_7522dff59dec
is: P04054
has only substance units: false
type: Species
initial concentration: NaN
name: PLA2G1B
is encoded by: hsa:5319
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

metaM oh1 c
has only substance units: false
name: hydroxide ion
is: HMDB01039
is: SBO:0000247
type: Species
initial amount: NaN
is: C01328
initial concentration: 1.0
notes: FORMULA: HO CHARGE: -1
constant: false
boundary condition: false

metaM chsterol m
has only substance units: false
initial concentration: 1.0
is: CHEBI:16113
is: HMDB00067
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
boundary condition: false
initial amount: NaN

metaR NNATn
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110064#
type: Reaction
reversible: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:12574164 NOTES:IT
fast: false
modifier: MODEL1310110064#
name: nicotinate-nucleotide adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.1
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_40347925_06fd_4a50_a490_9c884f055195
type: Species
initial amount: NaN
is encoded by: hsa:23236
name: PLCB1
is: Q9NQ66
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaM imp c
is: HMDB00175
is: CHEBI:58053
is: C00130
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
name: IMP
constant: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130

http://identifiers.org/biomodels.db/MODEL1310110064#_2c9ace2c_10ef_41c1_9da8_07a37b58eb92
boundary condition: true
has part: B4E3E9
is: SBO:0000297
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:4967
initial concentration: NaN
name: DLD:DLST:OGDH:PDHX
type: Species

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_dfae005d_9461_48cc_8506_00ae22c63e05
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: GALNT13
initial concentration: NaN
is: Q8IUC8
is encoded by: hsa:114805
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_161297d7_1b3e_43c4_9949_11e079eb4850
name: SLC6A2
is encoded by: hsa:6530
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q96KH8
boundary condition: true
initial amount: NaN
has only substance units: false

metaM mag hs e
name: monoacylglycerol 2
constant: false
boundary condition: false
is: CHEBI:60479
initial amount: NaN
type: Species
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM tcynt e
is: CHEBI:18022
initial concentration: 1.0
is: SBO:0000247
constant: false
name: thiocyanate
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_1183ba4e_f76b_480d_9c3d_529ce067e233
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:159963
name: SLC5A12
is: SBO:0000252
type: Species
constant: false
is: Q1EHB4
has only substance units: false

metaM dc2coa m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
boundary condition: false
type: Species
constant: false
has only substance units: false
name: trans-Dec-2-enoyl-CoA
is: CHEBI:61406

metaR FADH2ETC
reversible: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110064#
name: Complex II reaction for respiratory chain
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR r0423
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR RE2660C
reactant: MODEL1310110064#
type: Reaction
name: RE2660
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
kinetic law: MODEL1310110064#
is described by: ECO:0000000
fast: false
product: MODEL1310110064#
is: SBO:0000176

metaM pmtcrn x
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
name: L-palmitoylcarnitine
constant: false
initial amount: NaN
is: CHEBI:17490
is: HMDB00222

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM cs a deg3 l
constant: false
is: HMDB00127
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
initial amount: NaN
is: CHEBI:15748
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: SBO:0000247
has only substance units: false

metaR CDIPTr
name: phosphatidylinositol synthase (Homo sapiens)
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.8.11
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD

metaR NDPK8
product: MODEL1310110064#
name: Nucleoside-diphosphate kinase (ATP:dADP)
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
modifier: MODEL1310110064#
fast: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_3b5ed788_55c8_43ac_9f0f_568c09ac477e
boundary condition: true
name: SLC17A5
is encoded by: hsa:26503
is: Q9NRA2
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaM xyl D c
is: CHEBI:15936
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: aldehydo-D-xylose

metaM adrncoa c
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: adrenyl coenzyme A
boundary condition: false
initial amount: NaN

metaR COAtp
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: coenzyme A transport, peroxisomal
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_511e335f_01a7_422f_86c5_42707b222d40
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: PIGF
is encoded by: hsa:5281
has only substance units: false
is: SBO:0000252
is: Q07326
initial concentration: NaN

metaM thymd c
is: CHEBI:17748
has only substance units: false
is: C00214
is: HMDB00273
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Thymidine
constant: false

metaM fum c
is: CHEBI:29806
is: HMDB00134
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C00122
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
constant: false
is: SBO:0000247

metaM ach c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15355
type: Species
name: acetylcholine
constant: false
has only substance units: false
is: HMDB00895
is: SBO:0000247
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

http://identifiers.org/biomodels.db/MODEL1310110064#_6b83b8d5_b0c0_4e79_a416_ab8e8c8c3fd0
name: _LOC728997_1_c
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:LOC728997
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_45121b20_fec8_4d99_b90f_778cdd7eed0d
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8608
initial amount: NaN
name: RDH16
boundary condition: true
type: Species
is: O75452
initial concentration: NaN
constant: false

metaR r0377
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110064#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#

metaR NDPK9
fast: false
reactant: MODEL1310110064#
name: nucleoside-diphosphate kinase (ATP:IDP)
type: Reaction
is: SBO:0000176
product: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110064#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_05c17ed7_cc3e_4e3e_a350_73646ffb5f20
has only substance units: false
constant: false
name: _AI934540_1_c
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:AI934540
initial concentration: NaN
initial amount: NaN

metaR r1418
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000176
reactant: MODEL1310110064#
product: MODEL1310110064#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_fd763865_3bba_4e6e_a119_1365dea19b13
initial concentration: NaN
is encoded by: hsa:2687
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: GGT5
is: P36269

metaR PGISr
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.4
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
modifier: MODEL1310110064#
name: Prostaglandin I2 synthase
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110064#_08e446d6_0f50_4b40_a5e5_4080be5c8c56
constant: false
has only substance units: false
is: SBO:0000252
name: ALDH3B2
is: P48448
initial concentration: NaN
is encoded by: hsa:222
boundary condition: true
initial amount: NaN
type: Species

metaM CE1944 c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:36781
constant: false
type: Species
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
name: 1-pyrrolinium
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR TCYNTt
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)

metaR r0990
reactant: MODEL1310110064#
reversible: true
name: Postulated transport reaction
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_29fd351e_b9ce_41e8_9d0d_608ad2ab437b
initial concentration: NaN
is: P08397
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3145
name: HMBS

http://identifiers.org/biomodels.db/MODEL1310110064#_e3bddb84_db6b_44f2_b555_9ac1746773fc
initial amount: NaN
has only substance units: false
is encoded by: hsa:956
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: O75355
name: ENTPD3

metaR CITtam
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
modifier: MODEL1310110064#
product: MODEL1310110064#
name: citrate transport, mitochondrial
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
fast: false
type: Reaction

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaM orn e
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: Ornithine
is: CHEBI:0
initial concentration: 1.0
is: HMDB00214
is: C01602

metaM HC02121 c
initial amount: NaN
name: S-(hydroxymethyl)glutathione(1-)
initial concentration: 1.0
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:58758
has only substance units: false
constant: false

metaR NDPK6
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
fast: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110064#
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110064#
name: Nucleoside-diphosphate kinase (ATP:dUDP)

metaR r2400
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction

metaR r0993
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
is described by: ECO:0000000
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
reactant: MODEL1310110064#
is: SBO:0000185

metaR LEUKTRF4t
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: leukotriene F4 transport
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction

metaM xyl D e
type: Species
name: aldehydo-D-xylose
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15936

metaR COAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is: SBO:0000185
name: COA transporter, endoplasmic reticulum
reversible: true
product: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_de4ee7b4_1fe6_4d04_bd97_2c38ac7183a1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51166
type: Species
name: AADAT
initial amount: NaN
is: Q4W5N8
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_96b7ad98_24b8_42f4_87e7_44c54ca655a5
is encoded by: hsa:57127
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: Q9H310
initial concentration: NaN
boundary condition: true
name: RHBG

metaR URATEt
is described by: ECO:0000000
reversible: false
product: MODEL1310110064#
name: urate export from cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
fast: false

metaR FAOXC160
reversible: false
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR RE2660N
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110064#
name: RE2660
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
type: Reaction
product: MODEL1310110064#
is: SBO:0000176
fast: false

metaR NACHEX9ly
product: MODEL1310110064#
modifier: MODEL1310110064#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110064#

metaR r2370
fast: false
name: Nucleobase:Cation Symporter-2 (NCS2) TCDB:2.A.40.6.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12845532 NOTES:
is: SBO:0000185
reactant: MODEL1310110064#
product: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction

metaR ACACT10m
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is described by: ECO:0000134

metaR BILDGLCURt
fast: false
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110064#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_b4ac54e7_42b5_4bcf_b63d_eeb1f75fd93d
has only substance units: false
initial concentration: NaN
name: GPX4
initial amount: NaN
is: SBO:0000252
is: P36969
constant: false
is encoded by: hsa:2879
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_3eb8fb26_257c_4d1c_a8fb_f2a5c3b51e15
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: FOLR3
is: Q05C14
is encoded by: hsa:2352

metaM coa m
is: SBO:0000247
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: C00010
name: Coenzyme A
is: CHEBI:57287
boundary condition: false
has only substance units: false

metaM ach e
initial concentration: 1.0
has only substance units: false
is: HMDB00895
boundary condition: false
is: CHEBI:15355
type: Species
constant: false
is: SBO:0000247
name: acetylcholine
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

http://identifiers.org/biomodels.db/MODEL1310110064#_5d430123_989d_434b_8b5b_cb138fac24bb
name: SLC7A8:SLC3A2
has part: Q9UHI5
is encoded by: hsa:23428
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000297
initial concentration: NaN

metaR NDPK7
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dCDP)
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_a22a05d4_b89e_42f9_a520_71ae021342c6
is encoded by: hsa:114134
initial amount: NaN
name: SLC2A13
initial concentration: NaN
is: Q96QE2
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM chsterol r
constant: false
is: HMDB00067
is: CHEBI:16113
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
name: cholesterol
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

metaR THP2Ctp
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reversible: true
fast: false

metaR PROD2m
name: Proline dehydrogenase (m)
product: MODEL1310110064#
modifier: MODEL1310110064#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.99.8
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
reactant: MODEL1310110064#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_c9d257ae_2239_4148_a1c0_6fa1be1a8c47
is encoded by: hsa:2180
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: ACSL1
is: P33121
boundary condition: true
has only substance units: false

metaM crn m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00318
has only substance units: false
name: L-Carnitine
type: Species
is: SBO:0000247
is: HMDB00062
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347

metaM acgam c
is: CHEBI:17411
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
boundary condition: false
constant: false
is: HMDB00215
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR 2HBO
product: MODEL1310110064#
modifier: MODEL1310110064#
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
fast: false
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27

http://identifiers.org/biomodels.db/MODEL1310110064#_aa45cb4c_f932_4a8f_b08f_5a5fa43b2671
is: SBO:0000252
type: Species
initial amount: NaN
is: Q92819
has only substance units: false
name: HAS2
is encoded by: hsa:3037
initial concentration: NaN
constant: false
boundary condition: true

metaM leuktrB4 c
initial amount: NaN
is: HMDB01085
name: leukotriene B4(1-)
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57461

metaM 12ppd R c
boundary condition: false
is: CHEBI:28972
is: SBO:0000247
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: (R)-propane-1,2-diol
is: HMDB01881
initial concentration: 1.0

metaM orn c
type: Species
is: C01602
has only substance units: false
is: HMDB00214
initial concentration: 1.0
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:0
name: Ornithine
is: SBO:0000247

metaR r2371
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185

metaM coa n
name: coenzyme A(4-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
has only substance units: false
is: HMDB01423
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_2e28bbfe_40ea_41b0_b0ee_703885164d2a
has only substance units: false
type: Species
is: Q9NQR4
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56954
initial amount: NaN
name: NIT2

metaM gthrd c
type: Species
boundary condition: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
is: SBO:0000247
is: C00051
name: Reduced glutathione
is: HMDB00125
has only substance units: false
initial concentration: 1.0
is: CHEBI:57925
initial amount: NaN

metaM 3mgcoa m
type: Species
is: HMDB01057
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:57346
name: trans-3-methylglutaconyl-CoA(5-)
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
is: SBO:0000247

metaR O2Stx
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: superoxide anion transport via diffusion (peroxisome)
is: SBO:0000185
type: Reaction

metaR r0317
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000000
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110064#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_6c65945c_79f1_48ed_b6cd_a0c9a6fc072f
type: Species
is encoded by: hsa:10965
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: ACOT2
is: P49753
is: SBO:0000252
boundary condition: true

metaR NDPK4
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:dTDP)
is described by: ECO:0000269
fast: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM 7thf m
is: HMDB00032
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17759
boundary condition: false
constant: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
has only substance units: false
name: heptaglutamyl folate (THF)

metaR r0157
reactant: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
modifier: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.2
product: MODEL1310110064#

metaM gcald c
type: Species
is: CHEBI:17071
initial amount: NaN
is: HMDB03344
is: SBO:0000247
boundary condition: false
name: glycolaldehyde
has only substance units: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
constant: false
initial concentration: 1.0

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:15991
boundary condition: false
constant: false
name: Ferricytochrome c
initial amount: NaN
has only substance units: false

metaR r2372
fast: false
type: Reaction
is: SBO:0000185
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR NDPK3
product: MODEL1310110064#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:CDP)
modifier: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#

metaR NADtpu
kinetic law: MODEL1310110064#
fast: false
name: NAD transporter, peroxisome
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110064#
is described by: ECO:0000000
reversible: false
product: MODEL1310110064#

metaR ABUTD
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000269
reactant: MODEL1310110064#
is: SBO:0000176
name: Aminobutyraldehyde dehydrogenase
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_8e1246d0_4daf_461c_a7b2_254e3e4ec428
initial amount: NaN
initial concentration: NaN
name: _NOS2A_1_e
constant: false
boundary condition: true
is encoded by: hsa:NOS2A
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_6c6c843c_e280_4baa_99c7_b6bcd5351d04
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6241
type: Species
constant: false
is: P31350
initial concentration: NaN
initial amount: NaN
name: RRM2

metaM CE2421 m
type: Species
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
constant: false
is: HMDB02329
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: (3S)-3-hydroxylinoleoyl-CoA
boundary condition: false
is: CHEBI:30623
is: SBO:0000247

metaR r2401
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110064#
fast: false
reversible: false
reactant: MODEL1310110064#
is: SBO:0000185

metaR r0994
name: Facilitated diffusion
type: Reaction
is: SBO:0000185
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
product: MODEL1310110064#

metaM acgpail hs c
is: SBO:0000247
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
type: Species
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
is: CHEBI:57265
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_49befdc3_cfd8_4297_8c06_ec09b24d21f3
is: SBO:0000297
has part: P08195
type: Species
is encoded by: hsa:6520
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:56301
has only substance units: false
initial concentration: NaN
has part: Q9NS82
name: SLC7A10:SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110064#_26aa1fe0_980a_4f57_b135_254f4798c119
is: SBO:0000252
is encoded by: hsa:51733
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: UPB1
is: B3KNC1
initial concentration: NaN

metaM 7thf l
notes: FORMULA: C49H57N13O24 CHARGE: -8
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
name: heptaglutamyl folate (THF)
is: CHEBI:17759
is: HMDB00032
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_bd8a13dd_ba41_4c0e_9d4d_8b5d5599ec16
constant: false
boundary condition: true
is: P37287
is encoded by: hsa:5277
is: SBO:0000252
has only substance units: false
type: Species
name: PIGA
initial concentration: NaN
initial amount: NaN

metaR NDPK5
product: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dGDP)
is described by: ECO:0000269
fast: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_5a3a11a4_7b57_4fe8_8ffe_3d2f20a2ce10
initial amount: NaN
name: PTS
is encoded by: hsa:5805
is: Q03393
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaR r0156
product: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/2.7.1.40

http://identifiers.org/biomodels.db/MODEL1310110064#_4a8af5cb_30ba_4673_9b9b_16b917b84934
constant: false
has only substance units: false
is encoded by: hsa:55089
name: SLC38A4
is: Q969I6
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r2373
kinetic law: MODEL1310110064#
reversible: true
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_c2907809_2b27_4398_85e6_3350990378f2
has only substance units: false
constant: false
boundary condition: true
name: TK1
is encoded by: hsa:7083
initial concentration: NaN
is: SBO:0000252
is: P04183
type: Species
initial amount: NaN

metaR ACACtx
type: Reaction
fast: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: acetoacetate intracellular transport unknown mechanism
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_14a8ee40_0c2e_4a53_bc08_8445c02d9d62
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: SLC25A26
is encoded by: hsa:115286
initial amount: NaN
is: F8WAB8
initial concentration: NaN
constant: false

metaM leuktrB4 e
type: Species
has only substance units: false
is: HMDB01085
name: leukotriene B4(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false
initial concentration: 1.0
is: CHEBI:57461
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_a12920a4_fcb4_48a6_8d66_ac6c76bce9f5
initial amount: NaN
is: P49748
initial concentration: NaN
boundary condition: true
is encoded by: hsa:37
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: ACADVL

metaR GGH 5DHFe
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
name: Gamma-glutamyl hydrolase (5DHF), extracellular
reversible: false
fast: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR r2404
is: SBO:0000185
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110064#

metaM crn r
constant: false
is: CHEBI:16347
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
name: (R)-carnitine
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM coa r
has only substance units: false
is: HMDB01423
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
name: Coenzyme A
is: SBO:0000247
is: CHEBI:57287
constant: false
type: Species
is: C00010
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_8715befb_b112_44f6_b527_61267f2a479d
name: SDHB
is encoded by: hsa:6390
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P21912

metaR NDPK1
product: MODEL1310110064#
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:GDP)
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
fast: false

metaR r2374
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_b0ba4468_7302_4bd7_a83a_47cf251c2582
is: Q7Z4L0
name: COX8C
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:341947
has only substance units: false
boundary condition: true

metaR COAtn
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: true
name: coenzyme A transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_7dbb6651_bbf8_4356_84c4_794b1922e3ef
initial concentration: NaN
is: Q5JWV8
initial amount: NaN
constant: false
name: ACSL4
is: SBO:0000252
is encoded by: hsa:2182
type: Species
boundary condition: true
has only substance units: false

metaR RE3568C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
name: RE3568
reactant: MODEL1310110064#

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_485db595_0792_45cf_9f73_b3aaf045b59f
name: ENPP1
initial amount: NaN
is encoded by: hsa:5167
boundary condition: true
constant: false
is: P22413
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_1ab7516f_42e9_49ac_914f_332c29e34d30
has only substance units: false
is: SBO:0000252
name: DUT
boundary condition: true
constant: false
is encoded by: hsa:1854
initial concentration: NaN
initial amount: NaN
type: Species
is: P33316

http://identifiers.org/biomodels.db/MODEL1310110064#_784b9b39_e90e_4f06_9aec_f833e294e83b
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: P04075
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:226
name: ALDOA

http://identifiers.org/biomodels.db/MODEL1310110064#_729ba565_68b5_4c4d_af96_b199ac6a7003
is: SBO:0000252
name: _AI631997_1_m
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI631997
constant: false

metaR r2403
is described by: ECO:0000000
fast: false
reactant: MODEL1310110064#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
product: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR HISSNAT5tc
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR NDPK2
product: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110064#
reversible: true
name: nucleoside-diphosphate kinase (ATP:UDP)
is: SBO:0000176
modifier: MODEL1310110064#

metaR r2375
fast: false
reversible: true
kinetic law: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_2ca945ba_47ca_429f_9490_5eb0b7479295
is: SBO:0000252
boundary condition: true
name: _NM_001929_1_c
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:NM 001929
has only substance units: false

metaR CHOLESTle
is version of: http://identifiers.org/ec-code/3.1.1.13
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110064#
is described by: ECO:0000134
name: hydrolysis of cholesterol ester by cholesterol esterase
product: MODEL1310110064#
type: Reaction
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#

metaR COAtm
name: CoA transporter
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is described by: ECO:0000269
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
fast: false

metaR NACHEXA7ly
is: SBO:0000176
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110064#
type: Reaction
reversible: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#
name: beta-N-acetylhexosaminidase A, lysosomal

metaR GLCAASE7ly
name: beta-glucuronidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
product: MODEL1310110064#
reversible: false
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000

metaM o2 n
is: HMDB01377
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: dioxygen
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
is: CHEBI:15379
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_9a61a308_9c52_4ed4_9b33_4cfa564449a9
type: Species
is: SBO:0000252
boundary condition: true
name: CHAT
is encoded by: hsa:1103
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: D3DX95

metaM 3oddcoa m
is: CHEBI:27868
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial amount: NaN
has only substance units: false
is: HMDB03937
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: 3-Oxododecanoyl-CoA

metaR CYTK14
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,UTP)
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269

metaR r2377
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110064#
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR 25HVITD3tin
is described by: ECO:0000000
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
product: MODEL1310110064#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#
reversible: false
name: 25-hydroxyvitamin D3 transport in cytoplasm
type: Reaction

metaM orn m
is: HMDB00214
type: Species
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:46912
initial amount: NaN
is: C01602
boundary condition: false
initial concentration: 1.0
constant: false
name: Ornithine
has only substance units: false

metaM fol c
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: Folate

metaM sphmyln hs c
is: SBO:0000247
initial amount: NaN
is: HMDB02704
name: sphmyln_hs[c]
boundary condition: false
is: CHEBI:21338
notes: FORMULA: CHARGE: 0
constant: false
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_2c3049ce_3f55_41ec_bfb0_d81a064f4544
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PLA2G2D
type: Species
has only substance units: false
is encoded by: hsa:26279
initial amount: NaN
is: Q9UNK4
constant: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM tchola e
is: HMDB00036
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: taurocholic acid
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_cc415275_229d_438b_adfb_0e2666aadbfa
is: SBO:0000252
is encoded by: hsa:AA526438
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: _AA526438_1_m
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_bebf3d7f_b054_45a0_aa37_999e74e9c8a9
is: P54803
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: GALC
boundary condition: true
type: Species
is encoded by: hsa:2581

http://identifiers.org/biomodels.db/MODEL1310110064#_b8a8b438_cc79_45cd_942c_e8bd54fafaef
initial concentration: NaN
name: NDUFB8
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O95169
is encoded by: hsa:4714
type: Species
has only substance units: false
constant: false

metaM fol e
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0
name: Folate
is: HMDB00121

http://identifiers.org/biomodels.db/MODEL1310110064#_0cbe13d7_8ec0_4233_a349_baab0ca23231
is: H0UI06
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: COX7A2
has only substance units: false
is encoded by: hsa:1347
initial concentration: NaN
type: Species

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM q10 c
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: HMDB01072
is: CHEBI:46245
is: SBO:0000247
name: ubiquinone-10
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_80b30d6c_be15_44a2_947a_869e9b1a9f13
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:641371
is: SBO:0000252
name: ACOT1
is: E9KL42
type: Species
boundary condition: true

metaR r2376
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
reversible: true

metaR r1421
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
name: Free diffusion
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110064#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_b1edb99b_5c0e_47ef_b4c1_0bd9dd3f6b92
is encoded by: hsa:23428
constant: false
name: SLC7A8
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q86U05
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_019d0443_d86c_473d_8bd4_43012c59e2ad
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AA021081
name: _AA021081_1_r

metaR ALAt2r
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
name: L-alanine reversible transport via proton symport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD

metaM arach e
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial concentration: 1.0
is: CHEBI:32360
name: arachidate
boundary condition: false
is: HMDB02212
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_e2c8aad6_2954_4243_b172_610c15ef9776
is encoded by: hsa:AI620219
name: _AI620219_1_e
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c66e617b_e836_46d8_b6dd_a6d106d21c41
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: FOLR1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2348

http://identifiers.org/biomodels.db/MODEL1310110064#_ad905173_c601_4ee5_9bf8_fe574052dac7
name: CHAT
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:1103
is: Q6LEN5
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_2674609c_437f_4999_b08a_3d510a05c8ea
is: B4DUG1
name: SLC24A1
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:9187
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_47ec2ef4_b4ba_4180_be41_82eb634e6a57
name: PGK2
type: Species
is: SBO:0000252
is encoded by: hsa:5232
constant: false
is: P07205
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaR CYTK12
reactant: MODEL1310110064#
name: cytidylate kinase (dCMP,dCTP)
type: Reaction
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110064#

metaM 6a2ohxnt x
is: SBO:0000247
type: Species
is: HMDB12151
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
initial concentration: 1.0
name: 6-amino-2-oxohexanoic acid
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:17534

metaM HC02208 e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: prostaglandin-d1
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:27696
initial amount: NaN
type: Species
has only substance units: false

metaM nadph c
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
is: C00005
is: SBO:0000247
initial concentration: 1.0
is: HMDB00221
is: CHEBI:57783
constant: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_8b659f4b_7be3_424a_8ccf_99497ac2fdf8
type: Species
is: Q6IBC0
is: SBO:0000252
name: HMGCL
is encoded by: hsa:3155
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaR r2379
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_2986b2e5_fb67_4e26_b941_3017b5f1f1f3
boundary condition: true
name: DGKQ
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1609
has only substance units: false
type: Species
is: P52824
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_00f6adca_7393_4486_842c_cf81797ff3f3
initial amount: NaN
constant: false
has only substance units: false
name: NDUFAB1
initial concentration: NaN
is encoded by: hsa:4706
boundary condition: true
type: Species
is: O14561
is: SBO:0000252

metaR LEUKTRA4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
fast: false
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is described by: ECO:0000269
kinetic law: MODEL1310110064#
is: SBO:0000185
type: Reaction
name: leukotriene A4 transport

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

metaR r0494
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000000

metaM dcdp m
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
is: HMDB01245
name: dCDP(3-)
boundary condition: false
type: Species

metaM q10 e
initial concentration: 1.0
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01072
is: CHEBI:46245
type: Species
constant: false
name: ubiquinone-10

metaM cs e deg7 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
notes: FORMULA: C23H35O27S2 CHARGE: -3
initial concentration: 1.0
is: CHEBI:15936
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247

metaM o2 m
initial concentration: 1.0
is: SBO:0000247
is: C00007
initial amount: NaN
name: O2
is: HMDB01377
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
type: Species
has only substance units: false
boundary condition: false

metaR HMGCOAtm
is: SBO:0000185
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
product: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
type: Reaction
reversible: true
reactant: MODEL1310110064#

metaM ca2 c
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: HMDB00464
initial concentration: 1.0
type: Species
name: calcium(2+)
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:29108
constant: false
initial amount: NaN

metaR r0639
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
product: MODEL1310110064#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
fast: false

metaM dcdp n
constant: false
name: dCDP(3-)
is: CHEBI:58593
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
initial concentration: 1.0
is: HMDB01245
boundary condition: false

metaR r2378
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction
fast: false
is: SBO:0000185

metaR CYTK13
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dATP)
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction

metaM acgam l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
is: CHEBI:17411
is: HMDB00215
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: N-acetyl-D-glucosamine
type: Species
initial amount: NaN
is: SBO:0000247

metaR CYTK12n
modifier: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP),nuclear
is: SBO:0000176
type: Reaction
reversible: true

metaR CYTK10
type: Reaction
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110064#
name: cytidylate kinase (CMP,dGTP)
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110064#

metaM ethamp r
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
constant: false
type: Species
name: O-phosphonatoethanaminium(1-)
initial concentration: 1.0
boundary condition: false
is: HMDB00224
initial amount: NaN
is: CHEBI:58190
is: SBO:0000247
has only substance units: false

metaM pac c
initial concentration: 1.0
name: phenylacetate
is: SBO:0000247
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
boundary condition: false
type: Species
has only substance units: false
is: HMDB00209
is: CHEBI:18401
constant: false
initial amount: NaN

metaM man1p c
is: HMDB06330
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:35374
boundary condition: false
name: D-Mannose 1-phosphate
initial concentration: 1.0
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636

http://identifiers.org/biomodels.db/MODEL1310110064#_22f5ea36_bc9c_4f69_8425_70ee6577f4d8
name: NDUFV3
initial amount: NaN
is: SBO:0000252
is: P56181
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:4731

metaM gum e
has only substance units: false
type: Species
initial amount: NaN
name: gums
constant: false
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: CHEBI:57449
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_af57a1a5_0bbe_404b_9a68_7835ed3388e1
constant: false
is: SBO:0000252
initial amount: NaN
name: RPE
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6120
is: Q96AT9

http://identifiers.org/biomodels.db/MODEL1310110064#_25885d9d_c296_4fe4_b5cf_99225c954494
is encoded by: hsa:H17063
name: _H17063_1_m
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_faf8d7fa_94fd_4260_b1a8_cba08fb09736
initial amount: NaN
name: ACAT1
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:38
type: Species
is: SBO:0000252
constant: false
is: P24752

metaM HC02208 c
is: SBO:0000247
name: prostaglandin-d1
constant: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27696
boundary condition: false
type: Species

metaR r0638
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is: SBO:0000176
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.8.1.2
reactant: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110064#

metaR CYTK11
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110064#
name: cytidylate kinase (dCMP,dGTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
modifier: MODEL1310110064#

metaM bilirub r
is: SBO:0000247
has only substance units: false
is: CHEBI:57977
initial amount: NaN
constant: false
is: HMDB00054
boundary condition: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
name: bilirubin(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_78bcedde_0781_4c38_bf29_153008e6e078
has part: P55084
initial amount: NaN
has part: E9KL44
name: HADHA:HADHB
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3032
constant: false
is: SBO:0000297
has only substance units: false
is encoded by: hsa:3030

http://identifiers.org/biomodels.db/MODEL1310110064#_8bbcdf16_ae79_4505_96ea_35adc8ce0788
is encoded by: hsa:5330
type: Species
has only substance units: false
initial amount: NaN
is: Q59F77
boundary condition: true
constant: false
initial concentration: NaN
name: PLCB2
is: SBO:0000252

metaR DURIPP
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.4.2.3
reversible: true
modifier: MODEL1310110064#
is: SBO:0000176
name: deoxyuridine phosphorylase
type: Reaction
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
product: MODEL1310110064#
is described by: ECO:0000269

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_81d79a33_cc10_483d_a4fd_885b4527d52a
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SLC35D2
is encoded by: hsa:11046
is: SBO:0000252
constant: false
type: Species
is: Q76EJ3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ac954585_67be_41bf_a199_44813b809ec6
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P56556
is encoded by: hsa:4700
name: NDUFA6
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM pchol hs e
name: Phosphatidylcholine
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:16110
initial concentration: 1.0
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
has only substance units: false

metaM 56dthm c
constant: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:27468
is: HMDB00079
boundary condition: false
initial amount: NaN
name: 5,6-dihydrothymine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_bfd06f7c_dd53_4695_8798_2c9f843e613a
initial concentration: NaN
is: P23786
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:1376
boundary condition: true
name: CPT2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_23ecc2b2_8e89_455a_9dec_830b7ea87db9
is: P16219
is encoded by: hsa:35
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
name: ACADS
initial concentration: NaN
initial amount: NaN

metaM glyald m
is: HMDB01051
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17378
type: Species
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
boundary condition: false
constant: false
name: D-glyceraldehyde
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_cdeffbd9_d755_4adf_ae4b_4a48d55baf32
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:10449
has only substance units: false
constant: false
is: SBO:0000252
is: P42765
name: ACAA2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_49d0206d_9d21_495f_89cb_5d9ea3d0835c
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:5336
initial concentration: NaN
boundary condition: true
is: P16885
name: PLCG2
is: SBO:0000252
constant: false

metaR r0321
reversible: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
fast: false
type: Reaction
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reactant: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/6.3.5.2

metaM ca2 e
is: HMDB00464
name: calcium(2+)
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:29108
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076

metaM C05957 r
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:27485
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: SBO:0000247
is: HMDB02710
name: Prostaglandin J2

http://identifiers.org/biomodels.db/MODEL1310110064#_fb22d916_f9f1_41f6_b1e2_8a75e49d829f
initial amount: NaN
name: _X63359_1_c
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:X63359
constant: false
boundary condition: true
is: SBO:0000252

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR FRDPtc
kinetic law: MODEL1310110064#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport
product: MODEL1310110064#

metaM leu L m
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine
boundary condition: false
is: SBO:0000247
is: HMDB00687
constant: false
has only substance units: false
is: CHEBI:15603

http://identifiers.org/biomodels.db/MODEL1310110064#_ff393070_f780_4f9b_9cdc_04e9383ac098
initial amount: NaN
name: SLC5A10
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:125206
is: A0PJK1
initial concentration: NaN

metaR ARABR
modifier: MODEL1310110064#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
reactant: MODEL1310110064#
is described by: ECO:0000269
name: arabinose reductase
kinetic law: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction

metaR r0523
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
reactant: MODEL1310110064#
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110064#

metaM C04849 e
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: CHEBI:57449
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaM methf c
initial amount: NaN
is: CHEBI:57455
initial concentration: 1.0
is: SBO:0000247
is: HMDB01354
is: C00445
type: Species
constant: false
has only substance units: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
boundary condition: false
name: 5,10-Methenyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110064#_66940b0e_0af2_437b_b2fa_34990a715aef
initial amount: NaN
name: _AI824319_1_r
initial concentration: NaN
is encoded by: hsa:AI824319
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaR ASPDTDe
type: Reaction
name: D-aspartate transport, extracellular
reactant: MODEL1310110064#
reversible: true
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000134

metaM ha e
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
has only substance units: false
type: Species
name: hyaluronan
boundary condition: false
is: CHEBI:16336
constant: false
is: SBO:0000247

metaM pan4p e
initial concentration: 1.0
type: Species
is: C01134
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01416
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: CHEBI:47942
boundary condition: false
name: Pantetheine 4'-phosphate

http://identifiers.org/biomodels.db/MODEL1310110064#_58d71ee2_b6db_422a_97ad_8419802eb783
name: NOS3
constant: false
is: A0S0A7
type: Species
initial concentration: NaN
is encoded by: hsa:4846
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_a197141e_d9d2_4f38_b686_9765338ae73d
name: HADH
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:3033
initial concentration: NaN
type: Species
boundary condition: true
is: Q16836
is: SBO:0000252

metaM didp n
constant: false
has only substance units: false
initial amount: NaN
is: HMDB03536
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: SBO:0000247
is: CHEBI:28823
type: Species
boundary condition: false
name: dIDP

metaR DHPM1
is version of: http://identifiers.org/ec-code/3.5.2.2
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
name: dihydropyrimidinase (5,6-dihydrouracil)
product: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110064#
is described by: ECO:0000269

metaM xtsn c
initial concentration: 1.0
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
constant: false
boundary condition: false
is: HMDB00299
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:18107
name: xanthosine

metaR TXA2te
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
type: Reaction
name: thromboxane A2 transport
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ

metaR r0522
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
reversible: false
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176

metaM pchol hs c
name: Phosphatidylcholine
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
has only substance units: false
is: CHEBI:16110
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR CHLtm
product: MODEL1310110064#
reversible: true
name: choline transport via diffusion (cytosol to mitochondria)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
kinetic law: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000

metaR DNDPt11m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
reactant: MODEL1310110064#
name: dADP transport via dGDP antiport
fast: false
modifier: MODEL1310110064#
reversible: false

metaM occoa m
is: C01944
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)
is: SBO:0000247
is: HMDB01070
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
is: CHEBI:57386
constant: false
has only substance units: false
boundary condition: false

metaM HC01522 c
has only substance units: false
constant: false
is: CHEBI:28508
initial concentration: 1.0
name: Gentisate aldehyde
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_a811a1a9_b7ca_49c1_94a3_295f882dd77b
initial concentration: NaN
is encoded by: hsa:1375
type: Species
name: CPT1B
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: B7Z5T8
initial amount: NaN

metaR RETHe
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
name: retinyl ester hydrolase, extracellular
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR r2506
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: true
is: SBO:0000185
name: Utilized transport
is described by: ECO:0000000
type: Reaction
fast: false

metaR r0634
fast: false
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.1
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_4fb71b37_519f_41c5_a55c_319c0b704fe7
initial concentration: NaN
boundary condition: true
name: _AA629629_1_m
initial amount: NaN
constant: false
is encoded by: hsa:AA629629
is: SBO:0000252
type: Species
has only substance units: false

metaM ha l
name: hyaluronan
initial amount: NaN
has only substance units: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial concentration: 1.0
is: CHEBI:16336
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaR MGCHrm
product: MODEL1310110064#
reversible: true
fast: false
reactant: MODEL1310110064#
is: SBO:0000176
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
type: Reaction
modifier: MODEL1310110064#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110064#

metaM oaa c
initial concentration: 1.0
name: Oxaloacetate
notes: FORMULA: C4H2O5 CHARGE: -2
boundary condition: false
type: Species
is: HMDB00223
is: SBO:0000247
is: C00036
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:3338

metaM q10h2 c
is: SBO:0000247
type: Species
boundary condition: false
name: Ubiquinol-10
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
has only substance units: false
is: HMDB13111
constant: false
is: http://identifiers.org/pubchem.compound/6504740

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR FUMSO4tm
reactant: MODEL1310110064#
name: Fumarate:sulfate antiport, mitochondrial
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
product: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_044d943b_e9c2_42e6_bf60_77dfd496824f
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: FOLR1
is encoded by: hsa:2348
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_f3ca4147_6add_4908_b256_3b3045a45a3f
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: Q53F23
name: TBXAS1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6916

metaR r2046
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM chsterol c
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: cholesterol
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
is: CHEBI:16113

metaR 2OXOADOXm
modifier: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.8.1.4
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
is described by: ECO:0000304
reversible: false
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
is version of: http://identifiers.org/ec-code/2.3.1.61

http://identifiers.org/biomodels.db/MODEL1310110064#_e1861e7f_1d1e_4f00_ac40_fe36a19cce5d
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q92820
boundary condition: true
type: Species
name: GGH
initial amount: NaN
has only substance units: false
is encoded by: hsa:8836

metaR r2507
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is: SBO:0000185
name: Utilized transport

metaR LALDO2x
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110064#
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
type: Reaction

metaM 34dhoxmand m
name: 3,4-Dihydroxymandelate
type: Species
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: HMDB01866
initial amount: NaN
is: CHEBI:27637
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r0633
is version of: http://identifiers.org/ec-code/2.7.7.3
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110064#
is: SBO:0000176
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#

metaR GTHPm
product: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.11.1.15
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.12
kinetic law: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
fast: false
name: glutathione peroxidase, mitochondria

metaM didp c
name: dIDP
type: Species
is: SBO:0000247
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN
constant: false
is: HMDB03536
initial concentration: 1.0
boundary condition: false
is: CHEBI:28823
has only substance units: false

metaM CE5101 m
type: Species
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
has only substance units: false
constant: false
initial concentration: 1.0

metaM o2 x
initial amount: NaN
constant: false
is: HMDB01377
is: CHEBI:15379
is: SBO:0000247
is: C00007
boundary condition: false
type: Species
initial concentration: 1.0
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_1d2ca662_18bb_411d_b1f9_f3be89a33f67
has only substance units: false
is encoded by: hsa:223
initial concentration: NaN
name: ALDH9A1
type: Species
initial amount: NaN
is: P49189
constant: false
is: SBO:0000252
boundary condition: true

metaM mal L c
has only substance units: false
type: Species
is: HMDB00156
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: SBO:0000247
name: (S)-malate(2-)
is: CHEBI:15589
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM dcdp c
is: CHEBI:58593
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
type: Species
name: dCDP
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C00705

metaR 3SPYRSP
reactant: MODEL1310110064#
type: Reaction
fast: false
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
product: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
reversible: false

metaR CSBPASEly
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110064#
fast: false
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reversible: false

metaR PRISTCOAtx
reversible: true
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
is: SBO:0000185
name: pristcoa peroxisomal transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ

metaM pnto R c
is: CHEBI:7916
is: HMDB00210
has only substance units: false
boundary condition: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
initial amount: NaN
type: Species
name: (R)-Pantothenate
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_ad1a782f_225c_40f7_9755_d32e922618f6
is: SBO:0000252
constant: false
name: NDUFA13
has only substance units: false
initial amount: NaN
is encoded by: hsa:51079
type: Species
initial concentration: NaN
boundary condition: true
is: Q9P0J0

http://identifiers.org/biomodels.db/MODEL1310110064#_bf374acc_48d1_411e_a34f_b8979fb08db0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:18
boundary condition: true
is: P80404
constant: false
name: ABAT

metaR DM kdn c
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM kdn(c)
type: Reaction

metaR r2048
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
modifier: MODEL1310110064#

metaR r2508
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000000
name: Utilized transport
type: Reaction
fast: false
reactant: MODEL1310110064#

metaM ethamp c
initial amount: NaN
name: ethamp[c]
is: SBO:0000247
is: CHEBI:58190
type: Species
is: HMDB00224
constant: false
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
has only substance units: false
boundary condition: false

metaR DNDPt22m
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
reversible: false
name: dTDP transport via dUDP antiport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_a6d98b46_e5ef_424f_9891_d8c10bc6f8cd
initial concentration: NaN
initial amount: NaN
name: LDHB
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:3945
is: SBO:0000252
is: P07195

metaM pail hs c
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_d7f778ad_bc9c_449f_b7c5_2854e1a16fa5
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: DGKZ
is: B7Z6M3
is encoded by: hsa:8525

http://identifiers.org/biomodels.db/MODEL1310110064#_a6a6fe0d_faba_447d_8895_b5c7d1754743
is: SBO:0000252
constant: false
name: ALDH1A3
is encoded by: hsa:220
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: P47895

http://identifiers.org/biomodels.db/MODEL1310110064#_9c408393_ac8d_42ab_b4d1_3b2cc30ad973
boundary condition: true
is encoded by: hsa:26275
has only substance units: false
is: Q6NVY1
type: Species
name: HIBCH
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR DNDPt49m
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110064#
name: dTTP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
modifier: MODEL1310110064#

metaR TXA2tr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: thromboxane A2 intracellular transport
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
is: SBO:0000185

metaR GGH 7THFe
is: SBO:0000176
modifier: MODEL1310110064#
reversible: false
name: Gamma-glutamyl hydrolase (7THF), extracellular
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b1d81da3_5106_4b34_bb2c_0bd3a59b7e67
has only substance units: false
is encoded by: hsa:65010
is: Q9Y3Y1
initial concentration: NaN
name: SLC26A6
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaM galside hs c
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:12947
initial amount: NaN
boundary condition: false
has only substance units: false
name: D-galactosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110064#_242e32c8_9e85_471c_a720_b8dd4b5ba740
initial amount: NaN
has only substance units: false
type: Species
is: Q16831
constant: false
is: SBO:0000252
is encoded by: hsa:7378
name: UPP1
boundary condition: true
initial concentration: NaN

metaM q10 m
is: HMDB01072
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
name: ubiquinone-10
is: CHEBI:46245
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_505058c0_1061_48c3_b3ae_0303ab3969ec
initial amount: NaN
is encoded by: hsa:AI620219
type: Species
initial concentration: NaN
name: _AI620219_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_862b8514_8c0f_4a37_a935_18f7180ad4ab
type: Species
is: SBO:0000252
name: ACAA1
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:30
is: Q96CA6
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_458d6476_51bf_47bd_9d66_016a5602080f
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9194
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: SLC16A7
is: SBO:0000252
is: Q8NEM3

metaM 34dhmald m
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/7903
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
has only substance units: false
type: Species
is: HMDB06242
initial concentration: 1.0
is: C05577
constant: false
name: 3,4-Dihydroxymandelaldehyde
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_ebde3531_7dde_4e2c_a7bb_eaebb854434c
type: Species
is encoded by: hsa:6560
is: F5H066
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC12A4

metaM glyald c
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: C00577
is: CHEBI:17378
is: SBO:0000247
is: HMDB01051
name: D-Glyceraldehyde
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR TALA
reversible: true
is: SBO:0000176
name: transaldolase
is version of: http://identifiers.org/ec-code/2.2.1.2
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
modifier: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_2ce4ee13_12ab_48bb_b87f_6568ec8dcd92
initial amount: NaN
is: SBO:0000252
is: Q5TDP6
has only substance units: false
constant: false
is encoded by: hsa:51557
type: Species
boundary condition: true
initial concentration: NaN
name: LGSN

metaR CSAPASEly
product: MODEL1310110064#
is: SBO:0000176
reversible: false
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f0ea0d52_8995_43af_bf02_6de774c26414
is: Q8IZH9
constant: false
initial amount: NaN
is encoded by: hsa:2643
initial concentration: NaN
name: GCH1
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_21cdd34b_878c_4773_a088_76d18dc6def6
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:55568
type: Species
initial concentration: NaN
name: GALNT10

metaM 5dhf e
type: Species
is: SBO:0000247
is: HMDB06487
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
has only substance units: false
constant: false
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
boundary condition: false
initial amount: NaN

metaR r0853
kinetic law: MODEL1310110064#
reversible: false
name: Facilitated diffusion
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:

metaR r0630
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.3.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_cf299e4a_ec22_4af6_98a7_47813f43fe37
is encoded by: hsa:U37519
initial concentration: NaN
type: Species
has only substance units: false
name: _U37519_1_m
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r1906
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
reversible: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110064#_2638706c_806e_440d_bdc3_bdd9d9f96336
type: Species
is: SBO:0000252
is: Q8N5Z0
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: AADAT
has only substance units: false
is encoded by: hsa:51166

metaM thcholstoic c
constant: false
has only substance units: false
boundary condition: false
is: HMDB03873
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: CHEBI:18402

metaR ICDHyrm
reactant: MODEL1310110064#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Isocitrate dehydrogenase (NADP+)
modifier: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
type: Reaction

metaM dcamp c
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C03794
is: CHEBI:57567
is: HMDB00536
name: N6-(1,2-Dicarboxyethyl)-AMP
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaR GALNTg
fast: false
kinetic law: MODEL1310110064#
name: GalNAc transferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.41

metaM spmd c
name: Spermidine
is: HMDB01257
is: SBO:0000247
initial amount: NaN
is: CHEBI:57834
constant: false
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
type: Species
is: C00315
initial concentration: 1.0

metaM o2 r
name: O2
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
initial concentration: 1.0
initial amount: NaN
is: C00007
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110064#_1ecd2f45_c954_45fe_b785_ca87551f349b
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P46721
is encoded by: hsa:6579
name: SLCO1A2
has only substance units: false

metaM pacald c
is: SBO:0000247
initial concentration: 1.0
type: Species
name: phenylacetaldehyde
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB06236
constant: false
is: CHEBI:16424

metaM spmd e
is: CHEBI:57834
name: Spermidine
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01257
initial concentration: 1.0
is: C00315
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_7ba0e940_9b83_480b_a4c9_9586b213cb23
initial concentration: NaN
boundary condition: true
constant: false
name: PRPS2
has only substance units: false
is encoded by: hsa:5634
type: Species
initial amount: NaN
is: SBO:0000252
is: P11908

metaM galside hs e
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
constant: false
is: CHEBI:12947

metaR GLYCTDle
name: difussion of glycerol accross the brush border membrane
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110064#
reversible: true
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110064#

metaM acgam r
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00215
initial amount: NaN
name: N-acetyl-D-glucosamine
type: Species
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_5dd3efdb_4620_48ef_bab3_dfa3a898a404
type: Species
boundary condition: true
name: ACSS2
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q5QPH3
is encoded by: hsa:55902
has only substance units: false
initial amount: NaN

metaR NDPK2n
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
product: MODEL1310110064#
fast: false
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_42c1af93_a7a8_426d_b844_7c636888fa9a
name: LDHAL6B
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:92483
is: Q9BYZ2
has only substance units: false
boundary condition: true

metaR GGH 7THFl
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110064#
product: MODEL1310110064#
reversible: false
name: Gamma-glutamyl hydrolase (7THF), lysosomal
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_022bfe03_0cef_4ec7_af27_4f754b8ab25e
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: PDHX
has only substance units: false
initial amount: NaN
is: O00330
is encoded by: hsa:8050
is: SBO:0000252

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR r2041
reversible: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110064#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM HC01104 e
boundary condition: false
type: Species
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:61146
name: 4-nitrophenyl phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110064#_c464830b_2c1c_4fb7_b422_94bb511063fe
type: Species
is encoded by: hsa:AI926493
is: SBO:0000252
boundary condition: true
constant: false
name: _AI926493_1_m
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM 25hvitd3 e
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
type: Species
is: HMDB03550
is: CHEBI:17933
name: calcidiol
has only substance units: false
constant: false
initial concentration: 1.0

metaR CYTK9n
is: SBO:0000176
name: cytidylate kinase (CMP,dCTP),nuclear
product: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000185
reversible: true

metaR r0497
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false

metaR HMGCOAtx
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
reversible: true
is: SBO:0000185

metaM methf m
is: HMDB01354
is: CHEBI:57455
name: (6R)-5,10-methenyltetrahydrofolate
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_6bf7249f_0cc3_4998_8a9e_81e50c96ef19
is encoded by: hsa:92483
name: LDHAL6B
initial amount: NaN
has only substance units: false
is: Q9BYZ2
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_33f32ffa_89cc_4cbe_8271_500fb9802a4a
name: AMY1B
is: P04745
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:277
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_06eb712d_2ffa_4578_9d67_3279b3d303e4
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:9962
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC23A2

metaR r1909
reversible: false
modifier: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaM chsterol e
is: HMDB00067
is: SBO:0000247
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16113
boundary condition: false
initial amount: NaN

metaM dcyt n
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00014
name: 2'-deoxycytidine
is: SBO:0000247
is: CHEBI:15698
initial amount: NaN
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

http://identifiers.org/biomodels.db/MODEL1310110064#_bcda3fc2_671a_49ea_af17_5568de4d041a
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: AFMID
is: Q63HM1
constant: false
is encoded by: hsa:125061
initial concentration: NaN

metaM q10h2 e
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
constant: false
name: Ubiquinol-10
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: SBO:0000247
initial concentration: 1.0

metaR ANTHte
name: Transport of anthranilate
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110064#
is described by: ECO:0000134
kinetic law: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_a43d494c_4c3c_4e26_a847_4c2d4ef65786
is: O43772
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC25A20
is encoded by: hsa:788
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_2775965c_eca3_4e26_89be_fd8a03a77953
has only substance units: false
boundary condition: true
is: P49327
constant: false
is: SBO:0000252
is encoded by: hsa:2194
name: FASN
initial concentration: NaN
initial amount: NaN
type: Species

metaR HAtly
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
name: hyaluronan transport, extracellular to lysosome
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR FAEL204
is: SBO:0000176
fast: false
type: Reaction
name: fatty-acyl-CoA elongation (n-C20:4CoA)
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
is described by: ECO:0000000
modifier: MODEL1310110064#

metaM galside hs g
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947

http://identifiers.org/biomodels.db/MODEL1310110064#_a27eb834_d9fa_4246_ba42_538f8613b466
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC22A2
boundary condition: true
constant: false
is encoded by: hsa:6582
is: SBO:0000252
has only substance units: false

metaR GGH 7DHFe
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_1ac4fdd7_f9ca_4a7a_9c5a_7beb0ecf9aeb
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4702
initial amount: NaN
name: NDUFA8
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is: B1AM93

metaM pnto R e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
type: Species
is: HMDB00210
constant: false
name: (R)-Pantothenate
has only substance units: false

metaR DNDPt34m
kinetic law: MODEL1310110064#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
fast: false
is described by: ECO:0000269
modifier: MODEL1310110064#
product: MODEL1310110064#
name: dGDP transport via dTDP antiport
reactant: MODEL1310110064#

metaM mal L e
boundary condition: false
is: HMDB00156
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:15589
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
name: (S)-malate(2-)
type: Species

metaM pan4p m
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
constant: false
is: CHEBI:47942
is: SBO:0000247
initial concentration: 1.0
type: Species
name: pantetheine 4'-phosphate(2-)
is: HMDB01416

metaM 25hvitd3 c
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
boundary condition: false
initial amount: NaN
has only substance units: false
name: calcidiol
type: Species
is: HMDB03550
is: CHEBI:17933
constant: false
initial concentration: 1.0

metaM pheme e
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: C00032
is: SBO:0000247
is: HMDB03178
type: Species
has only substance units: false
initial amount: NaN
name: Protoheme
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17627

metaM tdchola e
boundary condition: false
constant: false
is: HMDB00951
type: Species
initial concentration: 1.0
name: taurochenodeoxycholate
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247
initial amount: NaN
is: CHEBI:9407

metaM cytd e
type: Species
name: Cytidine
initial amount: NaN
constant: false
is: HMDB00089
has only substance units: false
is: C00475
is: CHEBI:17562
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475

metaR SERGLYexR
fast: false
reactant: MODEL1310110064#
name: L-Serine/Glycine reversible exchange
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000304
reversible: true

metaR ALDD2xm
fast: false
modifier: MODEL1310110064#
is described by: ECO:0000134
type: Reaction
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
reversible: false
product: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD

metaM acgal c
has only substance units: false
is: CHEBI:28037
name: N-acetyl-D-galactosamine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: HMDB00212
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

metaM nadph r
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00221
is: CHEBI:57783
boundary condition: false
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
is: C00005

metaR r2525
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
fast: false
type: Reaction
is: SBO:0000185

metaR r0989
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000185
type: Reaction
name: Postulated transport reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#

metaR HSD3A2r
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110064#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ

http://identifiers.org/biomodels.db/MODEL1310110064#_f3597df3_9f05_46f5_a53e_46c691d81fb8
is encoded by: hsa:80025
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: PANK2

metaM 4abut e
initial concentration: 1.0
name: 4-Aminobutanoate
type: Species
is: CHEBI:3628
is: HMDB00112
boundary condition: false
has only substance units: false
constant: false
is: C00334
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247

metaM cholp c
initial amount: NaN
is: CHEBI:295975
has only substance units: false
constant: false
name: choline phosphate(1-)
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588

http://identifiers.org/biomodels.db/MODEL1310110064#_ffde2319_e85d_4c64_acd5_967ac1803751
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM h2o2 c
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: HMDB03125
is: CHEBI:16240
name: Hydrogen peroxide

metaM anth c
is: HMDB01123
initial amount: NaN
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
type: Species
is: CHEBI:16567
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: anthranilate
boundary condition: false

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_3120cbf3_3b97_42d3_9612_9700923db07e
constant: false
initial concentration: NaN
initial amount: NaN
name: VNN1
type: Species
boundary condition: true
is encoded by: hsa:8876
is: O95497
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_3a66bf07_0612_47ad_bc3c_f0732c523a22
type: Species
is: F8VQS7
is: SBO:0000252
is encoded by: hsa:55967
boundary condition: true
initial concentration: NaN
name: NDUFA12
constant: false
initial amount: NaN
has only substance units: false

metaM cs c deg3 l
has only substance units: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial concentration: 1.0
type: Species
is: SBO:0000247
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3
is: HMDB00127
constant: false
is: CHEBI:15748
boundary condition: false
initial amount: NaN

metaM co e
boundary condition: false
name: carbon monoxide
is: CHEBI:17245
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01361
initial amount: NaN
is: SBO:0000247
type: Species

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_a40a46e7_26b1_424f_b597_fced9bb7e53c
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: CYB5D1
initial concentration: NaN
is encoded by: hsa:124637
is: SBO:0000252
type: Species
is: Q6P9G0

metaR SBT Dtde
is: SBO:0000185
name: D-sorbitol transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
reactant: MODEL1310110064#
reversible: true
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_a0751c13_887e_470a_a037_3b6cb15fe512
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80025
name: PANK2
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_e0c430ef_93c6_4f34_a05f_e7db743490b7
is encoded by: hsa:AW299740
constant: false
type: Species
name: _AW299740_1_m
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR MI14PP
type: Reaction
name: inositol-1,4-bisphosphate 1-phosphatase
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
kinetic law: MODEL1310110064#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.3.57
modifier: MODEL1310110064#
fast: false

metaM pheme c
type: Species
is: C00032
is: SBO:0000247
is: HMDB03178
name: Protoheme
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17627
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
has only substance units: false

metaM cytd c
is: SBO:0000247
name: Cytidine
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00089
is: C00475
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562
boundary condition: false

metaM crm hs l
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: N-acylsphingosine
is: CHEBI:52639
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaM nadh x
is: C00004
type: Species
is: CHEBI:57945
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
is: HMDB01487
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_15fe957a_2f5e_4986_b3da_6bd6677c2238
is: SBO:0000252
name: ECHS1
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: P30084
constant: false
initial concentration: NaN
is encoded by: hsa:1892

http://identifiers.org/biomodels.db/MODEL1310110064#_9a3f829d_936f_44b7_a037_44b024adfe10
has only substance units: false
is encoded by: hsa:C7orf24
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: _C7orf24_1_m
constant: false
boundary condition: true

metaR 7THFtl
kinetic law: MODEL1310110064#
reversible: false
type: Reaction
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
is: SBO:0000185
product: MODEL1310110064#
name: 7-glutamyl-THF transport, lysosomal
is described by: ECO:0000000

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_5c318402_1fd2_4e42_a7c9_e342191f7e42
constant: false
boundary condition: true
is: Q9P0J0
is encoded by: hsa:51079
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: NDUFA13
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_9466dce3_38d2_4dfd_90c6_883492f9cd2c
type: Species
constant: false
is encoded by: hsa:4831
boundary condition: true
is: P22392
name: NME2
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_88895b75_e51c_4ab4_a009_59cebc66ad6a
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:123041
initial amount: NaN
name: SLC24A4
initial concentration: NaN
type: Species

metaM dolp U c
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57683
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
type: Species
name: dolichyl phosphate(2-)
boundary condition: false

metaM his L e
boundary condition: false
is: HMDB00177
initial concentration: 1.0
is: CHEBI:15971
type: Species
constant: false
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR TYRt
modifier: MODEL1310110064#
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
name: L-tyrosine transport
is: SBO:0000185
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_16d838c7_f243_4b77_afac_00ce4e3dbbf0
is encoded by: hsa:51227
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PIGP
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_80b7e6ba_1dc1_4f95_aa41_c6fc6f6534a4
is: Q86SR1
type: Species
boundary condition: true
is: SBO:0000252
name: GALNT10
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:55568
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_cf7018dc_4a7d_4b2f_bb46_0cbd0fccc5e4
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: SLC13A2
has only substance units: false
is: E7ETH5
initial concentration: NaN
is encoded by: hsa:9058
initial amount: NaN

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaR 7THFtm
type: Reaction
kinetic law: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
name: 7-glutamyl-THF transport,m mitochondrial
product: MODEL1310110064#

metaR PI4PLC
fast: false
type: Reaction
product: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: phosphatidylinositol 4-phosphate phospholipase C
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD

metaM anth e
name: anthranilate
constant: false
is: SBO:0000247
is: HMDB01123
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16567
initial amount: NaN
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1

metaR GGH 6THFl
modifier: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6THF), lysosomal
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
fast: false

metaM h2o2 e
initial amount: NaN
is: CHEBI:16240
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: HMDB03125
type: Species
name: hydrogen peroxide
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_4d5f63d8_4cd7_4071_8165_bdc1247bb93e
is: Q9H903
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:441024
initial concentration: NaN
initial amount: NaN
name: MTHFD2L

http://identifiers.org/biomodels.db/MODEL1310110064#_be54a932_02c5_490e_bb3c_9add99a26734
type: Species
is: O60733
name: PLA2G6
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8398
is: SBO:0000252
constant: false
initial amount: NaN

metaR UPP3S
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.75
name: uroporphyrinogen-III synthase
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
product: MODEL1310110064#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_9d84ffbb_ace8_4448_a20c_5f11b3bab7e4
name: SLC17A1
boundary condition: true
is encoded by: hsa:6568
constant: false
is: Q14916
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaR r0650
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110064#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#

metaR EX 34hpp
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR CDPDAGtm
fast: false
type: Reaction
name: intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reversible: true
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
reactant: MODEL1310110064#

metaM co c
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
boundary condition: false
is: HMDB01361
name: carbon monoxide
is: CHEBI:17245
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR NCNt
modifier: MODEL1310110064#
name: Na+/Ca2+-NH4+ exchange
is: SBO:0000185
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110064#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b2239026_7467_41a5_aaa3_9567fef219f0
initial concentration: NaN
type: Species
initial amount: NaN
name: CDIPT
is: A8K3L7
has only substance units: false
is encoded by: hsa:10423
boundary condition: true
constant: false
is: SBO:0000252

metaR VD3
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
name: Vitamin D3 formation
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110064#_67d677bd_f122_442c_b14c_d5af2606fd5b
is: Q9NWU1
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: OXSM
is: SBO:0000252
is encoded by: hsa:54995
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_65e035f7_09bf_4e76_85ce_e78226bfcc08
has part: P23921
constant: false
is encoded by: hsa:6241
is encoded by: hsa:6240
boundary condition: true
initial amount: NaN
is: SBO:0000297
has part: P31350
type: Species
has only substance units: false
initial concentration: NaN
name: RRM1:RRM2

http://identifiers.org/biomodels.db/MODEL1310110064#_6fd33b24_f756_4c39_8b9e_c18837daf10e
is: SBO:0000252
name: ACOX1
is encoded by: hsa:51
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: B4DK61
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_34494f85_9840_4596_9174_570c9d522056
boundary condition: true
is encoded by: hsa:210
is: SBO:0000252
is: P13716
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ALAD

metaM cyan c
boundary condition: false
constant: false
name: hydrogen cyanide
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB02084

http://identifiers.org/biomodels.db/MODEL1310110064#_adf555b9_4b12_44e7_aea7_bc8c0c4ec2ca
initial amount: NaN
is encoded by: hsa:10455
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O75521
constant: false
initial concentration: NaN
name: ECI2
type: Species

metaR r0386
is described by: ECO:0000000
reversible: false
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
reactant: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaM trdox m
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191
initial amount: NaN
constant: false
boundary condition: false
name: Oxidized thioredoxin

metaR r2521
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
name: Utilized transport
kinetic law: MODEL1310110064#

metaR r1050
product: MODEL1310110064#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110064#
fast: false
type: Reaction
is described by: ECO:0000000
name: Vesicular transport
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_56bb1999_4b4e_41b0_8294_943e29d82c42
type: Species
name: ADH1B:ADH1C
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
has part: P00326
is: SBO:0000297
is encoded by: hsa:126

metaM his L c
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
initial concentration: 1.0
name: L-histidine

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of (R)-Pantothenate
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
fast: false
reactant: MODEL1310110064#
reversible: true
is: SBO:0000185
is described by: ECO:0000134

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM HC01409 m
has only substance units: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: CHEBI:27540
is: SBO:0000247
name: Hexanoyl-CoA
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c77c4338_c537_45a2_929a_7da3424cffdd
initial amount: NaN
is: B3KUK6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: NT5C1B
constant: false
has only substance units: false
is encoded by: hsa:93034

metaM 2hb e
type: Species
is: CHEBI:1148
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
is: HMDB00008
constant: false
has only substance units: false
initial amount: NaN

metaR MAL Lte
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: Transport of L-malate
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM tre e
name: Trehalose
is: SBO:0000247
is: C01083
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16551
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: HMDB00975
has only substance units: false
type: Species

metaR RE1527M
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reversible: true
is: SBO:0000176
name: RE1527
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_59290924_3ea4_44f4_8604_71f2f9957224
constant: false
is encoded by: hsa:50614
is: SBO:0000252
is: Q9HCQ5
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: GALNT9

http://identifiers.org/biomodels.db/MODEL1310110064#_4412e7fb_48cb_4561_a829_8793d2b7d602
is encoded by: hsa:80025
constant: false
name: PANK2
initial concentration: NaN
is: SBO:0000252
is: Q6P1K9
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_ed93f80b_ca9e_49a7_b846_de1ebc8d426f
is encoded by: hsa:BG035985
name: _BG035985_1_c
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM CE1926 e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00127
initial amount: NaN
has only substance units: false
is: CHEBI:15748
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
name: gama-carboxyethyl-hydroxychroman
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_ba89c7cf_9c40_4b46_8b32_6466f536933b
type: Species
is: P48507
initial amount: NaN
constant: false
is encoded by: hsa:2730
initial concentration: NaN
name: GCLM
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM dcyt c
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
name: Deoxycytidine
has only substance units: false
is: CHEBI:15698
is: C00881
is: HMDB00014
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

metaM tdchola c
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00951
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
is: CHEBI:9407
constant: false
initial concentration: 1.0
name: taurochenodeoxycholate
type: Species

metaR r0384
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
product: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is: SBO:0000176
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_32992e42_1dd6_4ab1_8a39_92af1527e2d7
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: _R39999_1_c
is encoded by: hsa:R39999
boundary condition: true
type: Species
is: SBO:0000252

metaM 4abut c
boundary condition: false
is: C00334
initial amount: NaN
is: CHEBI:3628
has only substance units: false
is: HMDB00112
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
constant: false
name: 4-Aminobutanoate

metaR r0410
reversible: true
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110064#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaM cyan e
has only substance units: false
boundary condition: false
is: CHEBI:18407
name: hydrogen cyanide
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
initial concentration: 1.0
constant: false

metaM dutp n
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
name: dUTP
initial amount: NaN
is: HMDB01191
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17625

metaM amp x
name: AMP
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: C00020
is: CHEBI:456215
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM CE2422 m
boundary condition: false
initial concentration: 1.0
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: CHEBI:28387
type: Species
is: SBO:0000247
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
initial amount: NaN
is: HMDB11123
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b96f3cc1_245d_41f1_b921_1c7b9e6ff6b4
name: FOLR1
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2348
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f93cde66_e12e_4d29_89a9_5e7817db547e
boundary condition: true
constant: false
is: Q9H2X9
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: SLC12A5
is encoded by: hsa:57468

http://identifiers.org/biomodels.db/MODEL1310110064#_86caaa67_15ca_4e31_acff_3829ff7be6b2
has only substance units: false
is encoded by: hsa:2686
is: A0PJJ9
initial amount: NaN
constant: false
name: GGT7
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR RTOTALt
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
name: RTOTAL transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:

metaR r1538
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
reactant: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_02a4e016_fccd_498d_a494_75fefd895ed3
name: MYO5B
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q9H6Y6
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4645
initial concentration: NaN

metaR HIBDm
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.31
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110064#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
modifier: MODEL1310110064#
reversible: true
is described by: ECO:0000269
product: MODEL1310110064#

metaM 2hb c
constant: false
type: Species
initial amount: NaN
is: CHEBI:1148
boundary condition: false
initial concentration: 1.0
name: 2-Hydroxybutyrate
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
is: HMDB00008

metaR r0055
reactant: MODEL1310110064#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.7
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is described by: ECO:0000000
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
product: MODEL1310110064#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#

metaM gdp c
initial concentration: 1.0
has only substance units: false
constant: false
is: C00035
boundary condition: false
is: SBO:0000247
is: HMDB01201
name: GDP
is: CHEBI:58189
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR r0385
type: Reaction
product: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
fast: false
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_f8830131_9ef3_4728_99ee_05981d286dcf
type: Species
is encoded by: hsa:AA278423
boundary condition: true
has only substance units: false
name: _AA278423_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR PIter
fast: false
type: Reaction
product: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
name: phosphate transport, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110064#_d47f40be_7ca7_401d_b0a5_923e7f235845
boundary condition: true
is encoded by: hsa:27034
name: ACAD8
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q6ZWP6

metaR CHSTEROLtrc
name: transport of cholesterol into the cytosol
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
is described by: ECO:0000134
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110064#

metaR CYOOm3
name: cytochrome c oxidase, mitochondrial Complex IV
modifier: MODEL1310110064#
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.9.3.1
is described by: ECO:0000134
reactant: MODEL1310110064#

metaR r1051
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_c25524c9_19bf_4bca_b4bd_82fbf3213773
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:93183
has part: Q9H3S5
is: SBO:0000297
has only substance units: false
name: PIGX:PIGM
has part: Q8TBF5
initial concentration: NaN
constant: false
is encoded by: hsa:54965

metaR LEUKTRE4t
fast: false
reactant: MODEL1310110064#
name: leukotriene E4 transport
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
product: MODEL1310110064#
is: SBO:0000185

metaM gdp n
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
is: CHEBI:58189
type: Species
name: GDP(3-)
is: HMDB01201
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d7987ee6_b397_4120_9f7a_8de91613fd1a
initial amount: NaN
is encoded by: hsa:8801
initial concentration: NaN
has part: Q96I99
is encoded by: hsa:8802
boundary condition: true
constant: false
has part: P53597
type: Species
is: SBO:0000297
has only substance units: false
name: SUCLG2:SUCLG1

metaR FAOXC2252053m
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110064#
name: Beta oxidation of long chain fatty acid
type: Reaction
reversible: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM abt c
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: L-arabinitol
is: HMDB01851
is: CHEBI:18403

http://identifiers.org/biomodels.db/MODEL1310110064#_54e3cf35_fc7e_44d2_af7f_b6e2e7a2b607
type: Species
is: SBO:0000252
constant: false
name: PGM2
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55276
is: Q96G03

http://identifiers.org/biomodels.db/MODEL1310110064#_7e4b805f_c69c_4f82_ac62_40de4d23bce4
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI971036
is: SBO:0000252
name: _AI971036_1_x
type: Species
constant: false

metaM retinol e
name: retinol
boundary condition: false
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:50211
initial concentration: 1.0
is: HMDB00305
has only substance units: false

metaR r2382
is described by: ECO:0000000
product: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110064#
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_a9e4a3b0_6738_4238_9aff_75144af54a4f
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ND2
type: Species
constant: false
is: Q7GXY9
boundary condition: true
is encoded by: hsa:4536

http://identifiers.org/biomodels.db/MODEL1310110064#_2536d81a_cd6b_484f_adda_bc4f0807b18b
is: P05091
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:217
boundary condition: true
constant: false
name: ALDH2

metaR RE2655R
kinetic law: MODEL1310110064#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2655
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176

metaM pheme m
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB03178
is: CHEBI:17627
boundary condition: false
name: Protoheme
type: Species
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: C00032
initial amount: NaN

metaM cytd m
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17562
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: HMDB00089
type: Species
name: cytidine
initial amount: NaN

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR HCO3 CLt
modifier: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
kinetic law: MODEL1310110064#
is: SBO:0000185
name: bicarbonate transport (Cl-/HCO3- exchange)
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#

metaM lnlncgcoa c
has only substance units: false
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
is: CHEBI:57363
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06368

metaM gdp m
is: HMDB01201
is: SBO:0000247
constant: false
name: GDP
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: C00035
is: CHEBI:58189

metaM 4mop c
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
is: HMDB00695
is: CHEBI:17865

http://identifiers.org/biomodels.db/MODEL1310110064#_ebed5b95_474c_429c_861f_bc3e49652c0a
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:7371
constant: false
is: Q9BZX2
name: UCK2
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_933658cf_cc35_4df0_8231_65224ce2684f
type: Species
boundary condition: true
name: SLC17A2
is: O00624
is: SBO:0000252
is encoded by: hsa:10246
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaM nadh m
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57945
is: HMDB01487
constant: false
is: http://identifiers.org/pubchem.compound/3306
is: C00004
boundary condition: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced

metaM dutp m
is: SBO:0000247
name: dUTP
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01191
has only substance units: false
type: Species

metaR r0917
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110064#

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR H2Oter
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110064#
type: Reaction
reversible: true
name: H2O endoplasmic reticulum transport
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000

metaR CYTK11n
reactant: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000269
fast: false
name: cytidylate kinase (dCMP,dGTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110064#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_42f4def2_7039_4a59_b1cf_bed84a4960b8
has only substance units: false
initial concentration: NaN
type: Species
is: O14556
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:26330
name: GAPDHS
constant: false

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaM mercplaccys e
name: 3-mercaptolactate-cysteine disulfide
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB06512
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_67c80ec5_6f30_401c_a3ee_b7a3bc307981
initial amount: NaN
constant: false
has only substance units: false
is: Q9NS82
initial concentration: NaN
type: Species
name: SLC7A10
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56301

http://identifiers.org/biomodels.db/MODEL1310110064#_52f19297_714e_40f7_9a92_4f90c8e9add0
is encoded by: hsa:4712
is encoded by: hsa:4731
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000297
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has only substance units: false
boundary condition: true
has part: Q5VYT2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_4eaf3717_7684_4673_b9ed_7d2bd9f1bb17
is: SBO:0000252
is: B7Z7I0
constant: false
name: TKTL1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:8277
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_20281f08_ce6f_418b_9371_08d539ceafd0
is: SBO:0000252
initial amount: NaN
type: Species
name: CA3
constant: false
is: P07451
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:761

http://identifiers.org/biomodels.db/MODEL1310110064#_36ddf2c2_9540_47fb_8ea1_855a54b8bc19
is encoded by: hsa:AV727634
is: SBO:0000252
name: _AV727634_1_c
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaM sql r
boundary condition: false
initial concentration: 1.0
is: HMDB00256
is: SBO:0000247
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:15440
constant: false
name: squalene

metaM h2o2 m
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Hydrogen peroxide
is: C00027
constant: false
is: HMDB03125
boundary condition: false
is: CHEBI:16240
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_954d77fe_9caf_4418_94d2_a2a99eee7e14
type: Species
is encoded by: hsa:771
name: CA12
is: O43570
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_1b7bd908_af8a_4c60_9857_b6703d27f1e7
constant: false
has only substance units: false
name: ARSA
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P15289
is encoded by: hsa:410
type: Species
initial concentration: NaN

metaM akg c
name: 2-Oxoglutarate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: C00026
initial concentration: 1.0
is: CHEBI:16810
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00208
type: Species

metaR BILIRUBt2
is: SBO:0000185
modifier: MODEL1310110064#
is described by: ECO:0000269
name: bilirubin transport via bicarbonate countertransport
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
fast: false

metaR r1429
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
name: Free diffusion
is: SBO:0000185
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#

metaR BILGLCURtr
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
name: glucuronidated compound transport

metaM HC02214 c
is: SBO:0000247
boundary condition: false
is: CHEBI:28852
has only substance units: false
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
name: prostaglandin-f1alpha
initial amount: NaN
type: Species

metaR TREHe
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
reversible: false
type: Reaction
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.28
is: SBO:0000176
is described by: ECO:0000269
name: alpha,alpha-trehalase
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_00bca10e_81fc_4541_a032_96aab6c8934b
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: GPX2
boundary condition: true
is: SBO:0000252
is: P18283
is encoded by: hsa:2877
initial concentration: NaN

metaR r2380
product: MODEL1310110064#
reactant: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110064#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

metaR BTNt4i
name: Biotin uptake (antiport)
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
product: MODEL1310110064#
type: Reaction
reversible: false

metaM pan4p c
type: Species
boundary condition: false
name: Pantetheine 4'-phosphate
has only substance units: false
is: HMDB01416
constant: false
is: C01134
is: CHEBI:47942
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN

metaM abt e
is: CHEBI:18403
is: HMDB01851
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol

http://identifiers.org/biomodels.db/MODEL1310110064#_8b9e3841_25d0_426f_83c6_c0d28a8d0c91
initial concentration: NaN
name: PLCH2
boundary condition: true
is: O75038
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:9651

metaM 6dhf e
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
type: Species
name: hexaglutamyl folate (DHF)
is: HMDB06563
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_0872bc5c_60b7_48bc_8ea6_d8c2e9cbf75c
is: SBO:0000252
is encoded by: hsa:3284
boundary condition: true
is: P26439
constant: false
name: HSD3B2
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_e55e565d_de6d_43ba_8230_1f73b32cc93c
boundary condition: true
name: CHAT
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:1103
initial amount: NaN
initial concentration: NaN
is: P28329
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_763636c1_08f2_43da_9afd_da0b9d8fd283
boundary condition: true
name: NOS1
constant: false
is: B4DG68
initial amount: NaN
type: Species
is encoded by: hsa:4842
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR PRO Dtde
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
product: MODEL1310110064#
is: SBO:0000185
name: D-proline transport, extracellular
reactant: MODEL1310110064#

metaM accoa x
is: HMDB01206
has only substance units: false
boundary condition: false
is: CHEBI:57288
name: Acetyl-CoA
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: C00024
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaM nadph m
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
has only substance units: false
is: HMDB00221
is: SBO:0000247
boundary condition: false
is: CHEBI:57783
initial amount: NaN
type: Species
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaM 4mop e
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00695
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
name: 4-methyl-2-oxopentanoate

metaM h2o2 n
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16240
name: hydrogen peroxide

metaR BPNT
modifier: MODEL1310110064#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.7
product: MODEL1310110064#
reversible: false
name: 3',5'-bisphosphate nucleotidase
type: Reaction
is described by: ECO:0000269

metaR r0915
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: true
fast: false
is: SBO:0000185

metaM retinol c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
name: retinol
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00305
is: CHEBI:50211
initial concentration: 1.0

metaR r0276
type: Reaction
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is described by: ECO:0000000
fast: false
modifier: MODEL1310110064#
is: SBO:0000176

metaR PPItx
reversible: true
kinetic law: MODEL1310110064#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110064#
name: Diphosphate transporter, peroxisome
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR FAOXC16080m
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
product: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
reversible: false
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269

metaM mercplaccys c
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: HMDB06512
is: SBO:0000247
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR r2381
is: SBO:0000185
reversible: false
product: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR FDH
kinetic law: MODEL1310110064#
is described by: ECO:0000304
name: formate dehydrogenase
reactant: MODEL1310110064#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.6

metaM HC02214 e
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
type: Species
initial amount: NaN
name: prostaglandin-f1alpha
initial concentration: 1.0
is: CHEBI:28852

metaR MCPST
is version of: http://identifiers.org/ec-code/2.8.1.2
kinetic law: MODEL1310110064#
fast: false
type: Reaction
reactant: MODEL1310110064#
name: 3-mercaptopyruvate sulfurtransferase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110064#_86ac83ba_a8eb_4209_af37_22c1197c34f4
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:2639
has only substance units: false
name: GCDH
initial concentration: NaN
initial amount: NaN
constant: false

metaR r1427
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_468b8ab0_f2e1_417c_8945_3dc9453aabb6
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PLA2G3
type: Species
constant: false
has only substance units: false
is encoded by: hsa:50487
is: Q9NZ20

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_dd890519_92fe_4ec8_a9d0_5d2088bee3a7
is encoded by: hsa:3550
is: SBO:0000252
type: Species
name: IK
has only substance units: false
constant: false
is: Q13123
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR MDHm
fast: false
product: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37
modifier: MODEL1310110064#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
name: malate dehydrogenase, mitochondrial
reactant: MODEL1310110064#
is described by: ECO:0000134
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_ccadac36_6402_4184_a9df_fd19a30dabe1
name: GK
initial concentration: NaN
constant: false
boundary condition: true
is: B4DH54
has only substance units: false
is encoded by: hsa:2710
is: SBO:0000252
initial amount: NaN
type: Species

metaM gln L c
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
type: Species
name: L-glutamine
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18050
boundary condition: false

metaR GLYt4
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
fast: false
type: Reaction
reversible: false
name: glycine transport via sodium symport
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
is described by: ECO:0000269

metaM nadh r
constant: false
name: NADH(2-)
is: CHEBI:57945
initial concentration: 1.0
type: Species
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM cs e deg4 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00127
notes: FORMULA: C31H46NO38S4 CHARGE: -5
is: CHEBI:15748
constant: false
is: SBO:0000247
has only substance units: false

metaM arachcrn c
constant: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
initial amount: NaN
is: HMDB06460
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r2386
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
product: MODEL1310110064#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110064#

metaM CE4872 c
constant: false
is: CHEBI:15748
initial concentration: 1.0
is: HMDB00127
initial amount: NaN
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
has only substance units: false
type: Species
is: SBO:0000247

metaR r0166
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
product: MODEL1310110064#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176

metaR r0913
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_81b31558_15f2_4682_9e2e_2051e038fe62
name: AK1
has only substance units: false
is: P00568
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:203
initial amount: NaN
initial concentration: NaN

metaR r1428
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
name: Free diffusion
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
fast: false

metaR r1260
reversible: false
kinetic law: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false
name: EC:6.2.1.3
product: MODEL1310110064#
type: Reaction

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR NOt
name: NO transport (diffusion)
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110064#

metaR UPPN
is: SBO:0000176
modifier: MODEL1310110064#
fast: false
reversible: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: b-ureidopropionase
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110064#_442506d4_a737_44f6_a1c5_7f00dd62978d
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9BXI2
initial concentration: NaN
is encoded by: hsa:83884
constant: false
type: Species
initial amount: NaN
name: SLC25A2

http://identifiers.org/biomodels.db/MODEL1310110064#_5c403f88_90d2_4efd_8369_92d2b7e4427b
name: _LOC727762_1_m
has only substance units: false
is encoded by: hsa:LOC727762
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM mercplac c
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: http://identifiers.org/pubchem.compound/8118
has only substance units: false
name: 3-Mercaptolactate
constant: false
boundary condition: false
is: C05823
initial amount: NaN
type: Species
is: HMDB02127
initial concentration: 1.0
is: SBO:0000247

metaM dag hs c
is: CHEBI:18035
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

metaM itp c
initial amount: NaN
is: SBO:0000247
is: CHEBI:57614
initial concentration: 1.0
has only substance units: false
name: ITP(3-)
boundary condition: false
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
type: Species

metaR r2387
type: Reaction
reversible: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_1ce6a676_c4fd_4aac_bf73_988ec98e7891
initial concentration: NaN
has only substance units: false
name: PLA2G4A
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:5321
is: P47712

metaM pchol hs m
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16110
name: Phosphatidylcholine
has only substance units: false
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

http://identifiers.org/biomodels.db/MODEL1310110064#_6dcbf0da_eb0b_42fc_bb1a_14f142844b88
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:1743
boundary condition: true
name: DLST
is: P36957
is: SBO:0000252
initial amount: NaN
constant: false

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_30dfb85d_90e4_4e87_bb34_ee5c9b54ad23
is: P48728
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:275
boundary condition: true
name: AMT
initial concentration: NaN
has only substance units: false
constant: false

metaR RE1516M
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1516
modifier: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_18ac7505_232d_4ba6_8c42_729f23590a09
is: O00154
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ACOT7
constant: false
type: Species
has only substance units: false
is encoded by: hsa:11332

http://identifiers.org/biomodels.db/MODEL1310110064#_a155221a_c990_40e8_a71b_64f886ff54b6
name: LEFTY1
is encoded by: hsa:10637
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O75610
has only substance units: false

metaM utp n
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
name: UTP(4-)
constant: false
initial concentration: 1.0
is: HMDB00285
type: Species
has only substance units: false

metaR 1a25DHVITD3TRn
kinetic law: MODEL1310110064#
name: tanslocation of 1-alpha,25-Dihydroxyvitamin D3 to nucleus
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID: 16374421 NOTES:1-alpha,25-dihydroxy vitamin D3 binds to the vitamin D binding receptor protein, i.e. Located in the cytosol and together this complex is translocated to the nucelus. There it binds retenoid X-receptor and then to vitamin D response element located in the promotor region of selected genes.
type: Reaction
reversible: false

metaR r1116
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
reactant: MODEL1310110064#
reversible: true
fast: false

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaM gln L e
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
boundary condition: false
name: L-glutamine
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:18050
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_cf91a661_e192_4906_82c7_feb9b8eb0811
name: DGKI
initial concentration: NaN
is encoded by: hsa:9162
constant: false
is: SBO:0000252
initial amount: NaN
is: O75912
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_610f7ed2_0a15_4b6d_9fe7_ad0725c5c576
name: SDR16C5
has only substance units: false
is: B3KT84
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:195814
type: Species
initial concentration: NaN

metaR r2384
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
type: Reaction
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM trdox c
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
is: C00343
is: CHEBI:18191
constant: false
initial amount: NaN

metaM 11 cis retfa e
initial concentration: 1.0
boundary condition: false
is: CHEBI:57454
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00972
name: fatty acid 11-cis-retinol
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0

metaR r0911
reversible: true
name: Facilitated diffusion
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

metaR FTHFL
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110064#
type: Reaction
name: Formate-tetrahydrofolate ligase
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR r0541
modifier: MODEL1310110064#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
kinetic law: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110064#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
reactant: MODEL1310110064#
reversible: true

metaR r1262
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: EC:6.2.1.3
reversible: false
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR DOLMANP Uter
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: false
name: dolichol-phosphate mannose flippase (uterus)
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_c2fd817c_91d7_41b3_882b_734bad52d5fb
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: _728226_1_m
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:728226

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR r2385
fast: false
kinetic law: MODEL1310110064#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
reversible: false

metaR URIt5le
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: uridine transport in via sodium symport (1:2)
fast: false
reactant: MODEL1310110064#
type: Reaction

metaM itp e
is: CHEBI:57614
initial concentration: 1.0
is: HMDB00189
has only substance units: false
boundary condition: false
name: ITP(3-)
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

http://identifiers.org/biomodels.db/MODEL1310110064#_0d425c59_4f34_440f_ab76_a4121621f61f
is: Q9BY07
is encoded by: hsa:57835
is: SBO:0000252
name: SLC4A5
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaR ME1m
type: Reaction
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.38
modifier: MODEL1310110064#
name: malic enzyme (NAD), mitochondrial

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR ME2m
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.38
is: SBO:0000176
type: Reaction
name: malic enzyme (NADP), mitochondrial
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
fast: false
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.40
reactant: MODEL1310110064#
modifier: MODEL1310110064#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_47974ac8_757a_4472_bfda_128606dc86f0
initial amount: NaN
initial concentration: NaN
is: O94788
is: SBO:0000252
type: Species
name: ALDH1A2
has only substance units: false
constant: false
is encoded by: hsa:8854
boundary condition: true

metaM amp e
constant: false
is: SBO:0000247
is: CHEBI:456215
type: Species
name: AMP
initial amount: NaN
is: C00020
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR GLYCtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
name: glycerol transport
product: MODEL1310110064#
is: SBO:0000185

metaM pmtcrn c
type: Species
is: SBO:0000247
is: CHEBI:17490
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
initial amount: NaN
boundary condition: false
name: L-palmitoylcarnitine
constant: false

metaR r0594
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110064#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_3cd3f5fd_34f9_4424_a4fa_c0d0fa051011
is: P21953
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: BCKDHB
constant: false
initial concentration: NaN
is encoded by: hsa:594
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_bfeb0625_36b4_489f_8a0a_57a79634b99e
boundary condition: true
name: PRDX2
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:7001
has only substance units: false

metaM idour l
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
boundary condition: false
is: CHEBI:21338
type: Species
name: L-iduronate
initial amount: NaN
is: HMDB02704
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_f1dc6bc6_adcb_4796_9e33_f23c909c1a69
has only substance units: false
type: Species
boundary condition: true
is: P49585
constant: false
name: PCYT1A
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5130
initial amount: NaN

metaM alpam m
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
name: S-aminomethyldihydrolipoamide
initial concentration: 1.0
is: HMDB06239

http://identifiers.org/biomodels.db/MODEL1310110064#_9449f45f_2839_435f_a1bb_3a63ef3d2e02
constant: false
initial amount: NaN
is: Q16775
name: HAGH
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:3029
initial concentration: NaN

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM CE2424 m
constant: false
is: SBO:0000247
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: CHEBI:28387
initial amount: NaN
boundary condition: false
is: HMDB11123
type: Species
initial concentration: 1.0
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f1dac0b5_ac8d_4db7_9486_24174ccb2b53
boundary condition: true
name: GSS
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:2937
is: SBO:0000252
constant: false
is: P48637

metaR r2407
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_10eed203_a380_4233_a908_a0596cd3a1a0
constant: false
is: SBO:0000252
initial concentration: NaN
name: ACO1
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:48
boundary condition: true
is: P21399

http://identifiers.org/biomodels.db/MODEL1310110064#_46838b4e_1350_49c0_adf0_99ba20115c17
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q7LG56
name: RRM2B
constant: false
is encoded by: hsa:50484
has only substance units: false
type: Species
boundary condition: true

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM 2mpdhl m
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_86805ece_6cd1_4d58_8bf3_2b2a6a7d8076
boundary condition: true
is: SBO:0000252
name: ACP1
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:52
constant: false
initial amount: NaN
is: Q59EH3

metaR AHC
name: adenosylhomocysteinase
reversible: true
is described by: ECO:0000269
product: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/3.3.1.1
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
kinetic law: MODEL1310110064#

metaR CYTK8n
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110064#
name: cytidylate kinase (CMP,dATP),nuclear
reactant: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
reversible: true

metaR PPPGOm
reversible: false
type: Reaction
product: MODEL1310110064#
name: protoporphyrinogen oxidase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.3.4
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000304
fast: false

metaR O2t
name: o2 transport (diffusion)
reactant: MODEL1310110064#
reversible: true
fast: false
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
is: SBO:0000185
is described by: ECO:0000000

metaM ins c
boundary condition: false
initial amount: NaN
is: CHEBI:17596
is: SBO:0000247
is: C00294
has only substance units: false
initial concentration: 1.0
name: Inosine
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
type: Species
is: HMDB00195
constant: false

metaR r0595
kinetic law: MODEL1310110064#
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
product: MODEL1310110064#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
reversible: false
reactant: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_053f7453_bbe4_4fd6_bbe0_b328a36d8212
is encoded by: hsa:2356
type: Species
has only substance units: false
is: Q05932
name: FPGS
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_2f313a11_a360_4f57_952c_5a04bd091074
name: ALDH2
is: P05091
is: SBO:0000252
has only substance units: false
is encoded by: hsa:217
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_f8ae5058_c5be_47ee_8eb4_820311fe2704
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:210
name: ALAD
initial amount: NaN
initial concentration: NaN
is: Q6ZMU0

metaM fe3 c
has only substance units: false
is: SBO:0000247
name: Fe3+
is: HMDB12943
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 3
boundary condition: false
constant: false
type: Species

metaM ppbng c
is: C00931
name: Porphobilinogen
is: CHEBI:58126
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
is: HMDB00245
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r2408
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR XYLtly
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: Xylose efflux from lysosome
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_d776f9bc_1751_4718_b4df_bb3be4d73045
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: _HG2846_HT2983_1_m

http://identifiers.org/biomodels.db/MODEL1310110064#_81d3dca0_31d1_4e34_98a1_37c48048f0dc
is encoded by: hsa:30833
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: NT5C
is: Q8TCD5
is: SBO:0000252

metaR DAGK hs
modifier: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.107
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110064#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: Diacylglycerol phosphate kinase (homo sapiens)
kinetic law: MODEL1310110064#

metaR M4BTAer
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
reversible: false
kinetic law: MODEL1310110064#
name: M4B transamidase, endoplasmic reticulum
is described by: ECO:0000000
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (10026.1) and (128869.1) and (8733.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15208306,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_e83fb4b7_cc3d_4432_ac19_c4de6b15a5e2
is: SBO:0000252
name: _J03866_1_m
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:J03866
has only substance units: false
boundary condition: true
constant: false

metaM dolp U r
initial amount: NaN
type: Species
name: dolichyl phosphate(2-)
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c69c0709_5b08_43be_8902_1508e397ec7d
is encoded by: hsa:5279
has only substance units: false
name: PIGC
is: SBO:0000252
is: Q92535
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaR r0483
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_e0ab34a4_4331_43e7_b03d_ffcf6e8d2b12
is: SBO:0000252
has only substance units: false
is encoded by: hsa:56953
constant: false
is: Q9NPB1
name: NT5M
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaM akg m
type: Species
name: 2-Oxoglutarate
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810
initial amount: NaN
constant: false
is: HMDB00208
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00026
boundary condition: false

metaM dttp m
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: C00459
is: CHEBI:37568
name: dTTP
constant: false
type: Species
is: HMDB01342

metaM amp c
is: CHEBI:3322
name: AMP
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: C00020
initial concentration: 1.0
boundary condition: false
is: HMDB00045

http://identifiers.org/biomodels.db/MODEL1310110064#_0a03b9a7_32fa_4209_a19c_17b1c8cf1e71
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:2990
is: P08236
has only substance units: false
is: SBO:0000252
name: GUSB

metaR r0596
is: SBO:0000176
reactant: MODEL1310110064#
reversible: false
type: Reaction
modifier: MODEL1310110064#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
product: MODEL1310110064#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4

metaR OCDCAtr
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000185
name: fatty acid transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110064#_92e027cd_e1ea_42ad_b915_74916c57acda
boundary condition: true
is encoded by: hsa:1962
type: Species
constant: false
initial amount: NaN
is: Q9NY65
initial concentration: NaN
has only substance units: false
name: EHHADH
is: SBO:0000252

metaM dolmanp U c
has only substance units: false
constant: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human uterine homolog
is: SBO:0000247
initial amount: NaN
is: CHEBI:15809
boundary condition: false

metaR r2405
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reactant: MODEL1310110064#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#

metaR r2389
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110064#
reversible: false
type: Reaction

metaR r1434
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
name: Transport reaction
type: Reaction
reversible: false

metaM so3 c
has only substance units: false
is: HMDB00240
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17137
type: Species
name: Sulfite
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false
is: C00094
initial amount: NaN

metaM 4mop m
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:17865
is: HMDB00695

http://identifiers.org/biomodels.db/MODEL1310110064#_3ac04e49_297f_4a5a_beb6_57e8fed35f41
name: _AA854479_1_m
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA854479

http://identifiers.org/biomodels.db/MODEL1310110064#_b9cdcc22_eee4_4d64_8224_9c74eb8fb4b0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: ALDH7A1
has only substance units: false
is: E7EPT3
constant: false
is encoded by: hsa:501

http://identifiers.org/biomodels.db/MODEL1310110064#_fe1b2acb_74c4_4c7d_9064_56f67679d9d0
has only substance units: false
name: ABAT
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:18
boundary condition: true

metaR DADA
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
reactant: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
fast: false
type: Reaction
name: Deoxyadenosine deaminase
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110064#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b66f0abb_5a3b_4938_a128_616c32b24560
type: Species
is: P41222
constant: false
name: PTGDS
is encoded by: hsa:5730
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM accoa n
name: acetyl-CoA(4-)
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
is: SBO:0000247
initial amount: NaN
type: Species

metaM dttp n
initial amount: NaN
name: dTTP
is: HMDB01342
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00459
is: CHEBI:37568

http://identifiers.org/biomodels.db/MODEL1310110064#_c3c1edb8_c024_48f1_80a7_b8e13cb4019d
has only substance units: false
name: GLRX2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:51022
initial concentration: NaN

metaM ins e
initial amount: NaN
constant: false
type: Species
is: HMDB00195
is: CHEBI:17596
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Inosine
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: C00294

http://identifiers.org/biomodels.db/MODEL1310110064#_2ab52e1d_b7e2_49c9_8388_5e026bcab408
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: Q8WUX1
is encoded by: hsa:92745
boundary condition: true
name: SLC38A5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_84571246_069d_4483_9d3f_a465220d6e14
has only substance units: false
name: ACADL
constant: false
is: SBO:0000252
initial concentration: NaN
is: P28330
is encoded by: hsa:33
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_1954820b_7b5e_493d_8e7c_306d1088e90c
is: SBO:0000252
is encoded by: hsa:10400
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: PEMT

metaR r2388
reactant: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: false
modifier: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000

metaR r1433
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM fe3 e
is: SBO:0000247
has only substance units: false
is: HMDB12943
initial amount: NaN
name: Fe3+
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
type: Species
is: CHEBI:29034

metaM crm hs c
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
initial amount: NaN
is: CHEBI:52639
name: N-acylsphingosine
has only substance units: false
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_1824d42f_b0d4_4ebe_9fe4_38b9ec6304f7
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: COX8A
has only substance units: false
is: SBO:0000252
is: Q53XN1
constant: false
is encoded by: hsa:1351

metaR PSERT
is: SBO:0000176
kinetic law: MODEL1310110064#
reversible: false
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.52
fast: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
name: phosphoserine transaminase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:

metaR RE3245C
reversible: true
kinetic law: MODEL1310110064#
name: RE3245
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaM utp c
name: UTP
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:46398
is: SBO:0000247
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: C00075
initial concentration: 1.0
is: HMDB00285

metaR r0310
fast: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
reversible: false
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176

metaM gchola c
is: CHEBI:58235
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
initial concentration: 1.0
has only substance units: false
is: HMDB00138
is: SBO:0000247

metaM Rtotal c
notes: FORMULA: CO2FULLR CHARGE: -1
boundary condition: false
has only substance units: false
constant: false
name: R total
type: Species
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_1981da1b_2f5f_4bed_b630_727e22052cf1
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: O95498
is: SBO:0000252
name: VNN2
constant: false
is encoded by: hsa:8875

metaR UMPKn
product: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: UMP kinase, nuclear
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD

metaR MTHFD
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP)
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000176
reversible: true

metaR O2tm
fast: false
product: MODEL1310110064#
name: O2 transport (diffusion)
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185

metaR q10h2tc
name: transport of ubiquinol into cytosol
kinetic law: MODEL1310110064#
reversible: true
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110064#
fast: false

metaM HC02217 c
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:27647
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2
boundary condition: false
initial concentration: 1.0
type: Species

metaR r0311
modifier: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR GLUt7l
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
name: Glutamate transport, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110064#_9dc499cc_3478_4a2f_ada4_53332f535799
name: ALDH9A1
is: P49189
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:223
boundary condition: true
type: Species
constant: false

metaR r0647
name: Spontaneous reaction
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176

metaR r1431
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
type: Reaction
product: MODEL1310110064#
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
reversible: false
fast: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM 3aib D m
is: HMDB02299
name: D-3-Amino-isobutanoate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: C03265
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM akg e
name: 2-oxoglutarate(2-)
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
constant: false
is: CHEBI:16810
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_7c0b95c3_e7f4_4276_8afd_b131de512f60
is: SBO:0000252
constant: false
is: P55084
has only substance units: false
is encoded by: hsa:3032
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: HADHB

metaM for c
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: Formate
is: CHEBI:15740
has only substance units: false
is: SBO:0000247
is: C00058
initial amount: NaN
is: HMDB00142

metaR DNDPt19m
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110064#
product: MODEL1310110064#
name: dUDP transport via ATP antiport
fast: false

metaM lnlncgcoa m
has only substance units: false
is: SBO:0000247
is: HMDB06368
initial amount: NaN
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_852dc301_b9ff_4c13_8a40_181b1fbc17e5
is: SBO:0000252
constant: false
name: ACAD11
is: Q709F0
initial amount: NaN
type: Species
is encoded by: hsa:84129
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR THBPT4ACAMDASE
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
modifier: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reversible: false

metaR O2tn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reversible: true
name: O2 nuclear transport
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_d82b6940_d43f_4d28_9a07_8d8633b3f16a
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: P06865
boundary condition: true
name: HEXA
is encoded by: hsa:3073
initial amount: NaN

metaR r0160
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
reactant: MODEL1310110064#
is described by: ECO:0000000
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.1.3.2
is: SBO:0000176

metaM utp e
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:46398
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
is: HMDB00285
initial concentration: 1.0
name: UTP(4-)

http://identifiers.org/biomodels.db/MODEL1310110064#_9915d56f_7c56_4eae_a4d8_b455c152aa87
name: CA6
is: Q5FC00
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:765

http://identifiers.org/biomodels.db/MODEL1310110064#_31fe69ce_6497_4e9c_8707_09c21fbc2d94
initial amount: NaN
constant: false
is: Q16851
boundary condition: true
initial concentration: NaN
type: Species
name: UGP2
is: SBO:0000252
is encoded by: hsa:7360
has only substance units: false

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR 3HKYNAKGAT
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
type: Reaction
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110064#
product: MODEL1310110064#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110064#
is described by: ECO:0000304
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.64
is version of: http://identifiers.org/ec-code/2.6.1.7

metaM CE0785 m
is: CHEBI:57795
name: cis,cis-myristo-5,8-dienoyl-CoA
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
initial amount: NaN
is: SBO:0000247

metaR DINt
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110064#
is: SBO:0000185
name: deoxyinosine transport via diffusion
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
product: MODEL1310110064#

metaM ditp c
initial concentration: 1.0
name: dITP(4-)
constant: false
is: SBO:0000247
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial amount: NaN
has only substance units: false
type: Species
is: HMDB03537
boundary condition: false

metaR r2409
reactant: MODEL1310110064#
type: Reaction
reversible: false
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_d1f1ca29_c0bc_4c70_9a72_7a0af2db61b5
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: Q96C36
is encoded by: hsa:29920
name: PYCR2
initial concentration: NaN
has only substance units: false

metaR RE1233C
name: RE1233
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side

metaM dgsn c
is: C00330
name: Deoxyguanosine
is: CHEBI:17172
boundary condition: false
type: Species
has only substance units: false
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial concentration: 1.0
initial amount: NaN
is: HMDB00085
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_6ed2b183_b5bf_4e0f_87b9_d98b69c2e098
has only substance units: false
is: P00915
constant: false
is encoded by: hsa:759
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: CA1

http://identifiers.org/biomodels.db/MODEL1310110064#_55db5e3c_4fd8_4485_a7df_e94f3232f707
type: Species
name: CMAS
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:55907
is: Q8NFW8

metaM itp n
constant: false
type: Species
is: HMDB00189
name: ITP(3-)
boundary condition: false
is: CHEBI:57614
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR RE3218C
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.6.2
name: RE3218
is described by: ECO:0000000
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_4c6d1a72_7424_4edc_8a6e_b5079af843fb
initial concentration: NaN
is encoded by: hsa:4668
is: P17050
initial amount: NaN
type: Species
name: NAGA
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM Rtotal e
is: CHEBI:16988
notes: FORMULA: CO2FULLR CHARGE: -1
boundary condition: false
type: Species
name: R total
has only substance units: false
is: HMDB00283
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR r0480
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_bea81ffb_f24f_45d6_b1f3_8260e7dbc7b4
initial amount: NaN
is: Q9P212
is: SBO:0000252
name: PLCE1
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:51196

metaM HC01501 c
initial amount: NaN
is: CHEBI:33539
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
name: hydroxidodioxidosulfidosulfate(1-)

metaM gln L m
is: HMDB00641
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
name: L-glutamine
is: SBO:0000247
is: CHEBI:18050
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_54312d89_5234_42d0_8d5c_d322e397a66c
is encoded by: hsa:39
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: Q9BWD1
name: ACAT2
initial concentration: NaN
type: Species
is: SBO:0000252

metaM prostge2 c
is: HMDB01220
is: SBO:0000247
has only substance units: false
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
is: CHEBI:606564
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR O2tp
name: O2 transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
reversible: true

metaM HC02217 e
is: CHEBI:27647
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: prostaglandin-g2
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

http://identifiers.org/biomodels.db/MODEL1310110064#_23b4a6e5_a3d3_4e87_b08a_803b6a9756f4
name: SLC25A10
is encoded by: hsa:1468
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q9UBX3
is: SBO:0000252
constant: false

metaM aps c
type: Species
is: SBO:0000247
name: 5'-adenylyl sulfate(2-)
is: CHEBI:58243
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
initial amount: NaN
initial concentration: 1.0
is: HMDB01003
boundary condition: false
has only substance units: false
constant: false

metaR DNDPt10m
reactant: MODEL1310110064#
name: dADP transport via dCDP antiport
fast: false
modifier: MODEL1310110064#
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#

metaM dha e
name: glycerone
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16016
has only substance units: false
is: HMDB01882
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_028089bb_5d30_49c9_b57d_98cb73e6f694
is: P49902
is encoded by: hsa:22978
type: Species
is: SBO:0000252
name: NT5C2
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_77fce24c_3321_4054_8c6a_173b5c5c5925
is: P23786
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: CPT2
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:1376

metaR r0644
fast: false
reversible: true
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_b3e85cb3_e3b0_4d35_90a2_eeaf04e7bd6d
name: PLA2G12A
is: Q542Y6
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:81579
initial concentration: NaN
type: Species

metaR OROTGLUt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is: SBO:0000185
name: OROTGLUt
type: Reaction
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110064#_5859cdda_da61_4e45_9369_49815942cba4
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:R33828
name: _R33828_1_c
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_9e6ac117_df89_407c_a033_798bdc451924
is: SBO:0000252
initial amount: NaN
name: TUSC3
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:7991
constant: false

metaM amp m
is: HMDB00045
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: AMP(2-)
constant: false

metaM C02470 c
is: C02470
is: HMDB00881
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial concentration: 1.0
name: Xanthurenic acid
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/5485
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_d19bbd4c_e0a6_47ae_8b30_eb3f44496a90
type: Species
is: SBO:0000252
is encoded by: hsa:5052
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: PRDX1
initial concentration: NaN

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_f70b3830_061c_4f0b_9fbd_7244b42897dc
name: CA4
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:762
is: Q6FHI7
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_59a339bf_7530_4598_97fa_d6f634d549a5
type: Species
is: Q99685
initial amount: NaN
is: SBO:0000252
constant: false
name: MGLL
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11343
has only substance units: false

metaM adn e
boundary condition: false
is: C00212
name: Adenosine
is: CHEBI:16335
type: Species
is: HMDB00050
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

metaR PRO1xm
name: proline oxidase (NAD), mitochondrial
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000254
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176

metaM for e
name: formate
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
has only substance units: false
is: HMDB00142
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_824844c0_acc0_4bb7_a7f7_0193986c5367
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: HAO2
initial amount: NaN
is encoded by: hsa:51179
is: SBO:0000252

metaM 4abut m
is: SBO:0000247
has only substance units: false
is: C00334
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:16865
name: 4-Aminobutanoate
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: HMDB00112

metaM oh1 e
type: Species
is: C01328
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB01039
name: hydroxide ion
notes: FORMULA: HO CHARGE: -1

metaM mlthf m
has only substance units: false
name: 5,10-Methylenetetrahydrofolate
is: HMDB01533
constant: false
is: CHEBI:15636
initial amount: NaN
is: SBO:0000247
is: C00143
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143

http://identifiers.org/biomodels.db/MODEL1310110064#_42d800d5_e595_4941_bbdc_59cfc556476d
initial amount: NaN
boundary condition: true
name: HADHA
is encoded by: hsa:3030
constant: false
is: SBO:0000252
has only substance units: false
is: E9KL44
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_7b6fe13e_dbf3_4ce7_bbb3_9dcd45aed91f
type: Species
has only substance units: false
constant: false
name: PIGA
is encoded by: hsa:5277
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR MTHFD2
is described by: ECO:0000134
name: methylenetetrahydrofolate dehydrogenase (NAD)
type: Reaction
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
product: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
fast: false

metaR NDPK1n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000134
product: MODEL1310110064#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110064#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
reactant: MODEL1310110064#

metaR RE1342C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
fast: false
name: RE1342
reactant: MODEL1310110064#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaM L2aadp m
is: SBO:0000247
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
has only substance units: false
type: Species
boundary condition: false
is: HMDB00510
initial concentration: 1.0
initial amount: NaN
constant: false
name: L-2-aminoadipate(1-)

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaM prostge2 e
is: HMDB01220
has only substance units: false
name: prostaglandin E2(1-)
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:606564

metaR r1540
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
reactant: MODEL1310110064#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_2b3f44ec_dfb6_4bcf_95be_9f5fd9be0456
initial concentration: NaN
has only substance units: false
is encoded by: hsa:79611
is: Q9H6R3
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: ACSS3
constant: false

metaM ditp n
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:61382
type: Species
name: dITP(4-)
boundary condition: false
is: HMDB03537
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247

metaM lnlncgcoa r
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)

metaR r1771
reactant: MODEL1310110064#
reversible: false
type: Reaction
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false

metaR SUCCt4 2
type: Reaction
modifier: MODEL1310110064#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110064#
name: succinate transport via sodium symport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#

metaM idour e
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:21338
name: L-iduronate
is: HMDB02704
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_a9da418f_e183_4b6b_8eb9_9933c7fdb68f
is: Q16854
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:1716
name: DGUOK

http://identifiers.org/biomodels.db/MODEL1310110064#_dd9fe50a_53da_4360_aac6_d6b58280cbd4
is encoded by: hsa:5631
has only substance units: false
is: P60891
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: PRPS1
boundary condition: true

metaM ppcoa m
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: Propanoyl-CoA
is: SBO:0000247
is: CHEBI:57392
initial amount: NaN
boundary condition: false
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100

metaM gchola e
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0
has only substance units: false
name: glycocholate
is: HMDB00138
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0

metaM acgal l
is: SBO:0000247
is: HMDB00212
name: N-acetyl-D-galactosamine
type: Species
constant: false
boundary condition: false
is: CHEBI:28037
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132

metaM ptth m
constant: false
type: Species
boundary condition: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
has only substance units: false
is: CHEBI:16753
initial amount: NaN
name: pantetheine
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_41a63333_92ed_4daf_a8a3_cad0e992c30f
has only substance units: false
is: P22392
name: NME2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4831

metaM crm hs e
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:52639
name: N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110064#_655f11c9_a2bf_4041_93c5_3f184e595b4f
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AA081045
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AA081045_1_e
has only substance units: false

metaR DNDPt5m
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000269
name: dATP transport via dTDP antiport
is: SBO:0000185
fast: false
modifier: MODEL1310110064#
type: Reaction

metaR r0051
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is described by: ECO:0000000
fast: false
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_e6af68da_0c53_45ea_a667_b0f06f1e9d14
is encoded by: hsa:314
is: O75106
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: AOC2
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_b8ca1e7f_93f9_47b2_8354_a561dde47390
name: _728637_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:728637
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaR ASAH1
kinetic law: MODEL1310110064#
name: N-acylsphingosine amidohydrolase
reactant: MODEL1310110064#
reversible: false
product: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.23
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c28cb11b_7d61_4e21_814c_3a53f5f4a54c
is encoded by: hsa:5335
boundary condition: true
type: Species
is: Q9UFY1
has only substance units: false
name: PLCG1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM cspg c l
initial concentration: 1.0
constant: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: C00318
is: HMDB00062
boundary condition: false
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
is: SBO:0000247
type: Species
is: CHEBI:16347
initial amount: NaN
has only substance units: false

metaM dag hs r
initial amount: NaN
is: CHEBI:18035
name: diglyceride
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055

metaR r1996
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false
modifier: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR GGH 6THFe
is: SBO:0000176
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: Gamma-glutamyl hydrolase (6THF), extracellular
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110064#_7ba60310_c86f_4605_8649_113158dffe3a
is: P09972
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: ALDOC
initial concentration: NaN
is encoded by: hsa:230
constant: false

metaR r2519
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
fast: false
name: Utilized transport
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_44b09d27_e273_41c5_bdca_fcd2dc902c74
name: ALDH1A3
is: P47895
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:220

http://identifiers.org/biomodels.db/MODEL1310110064#_fa1877ed_e539_4fe5_bd4b_1508f93e6133
name: CHAT
constant: false
type: Species
is encoded by: hsa:1103
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q6LEN6
initial concentration: NaN

metaR O2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110064#
name: O2 transport, endoplasmic reticulum
is: SBO:0000185

metaM idour c
is: HMDB02704
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: CHEBI:21338
name: L-iduronate
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_0390e75a_38af_4ec5_879e_d2943da4669c
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: HADHB
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3032
is: P55084

metaM HC02187 c
type: Species
has only substance units: false
is: CHEBI:28774
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_18fb7a17_0f30_4464_8621_271d1249afcf
type: Species
initial amount: NaN
name: TPI1P2
boundary condition: true
constant: false
is encoded by: hsa:286016
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM arachcrn m
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false
is: HMDB06460
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: arachidyl carnitine
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_6bf8a463_5897_45ae_a9ef_178b6a135047
is: H7C5B8
type: Species
is: SBO:0000252
name: NDUFB2
initial amount: NaN
is encoded by: hsa:4708
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR RE1530C
kinetic law: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
product: MODEL1310110064#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110064#
is: SBO:0000176
name: RE1530

http://identifiers.org/biomodels.db/MODEL1310110064#_cddcb3c5_14f3_47a2_90d0_883c73603b9b
initial amount: NaN
constant: false
type: Species
name: LDHC
is encoded by: hsa:3948
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM 5adtststerone r
is: CHEBI:16330
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

metaM ocdcea e
boundary condition: false
constant: false
is: HMDB00207
is: CHEBI:0
initial amount: NaN
type: Species
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: C00712
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_74196f19_791d_43b1_9013_b9eba99a72a1
is: Q6LEN5
name: CHAT
is encoded by: hsa:1103
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_956d18b1_0cf1_4c58_941c_f0928837c11c
name: ENTPD2
initial concentration: NaN
constant: false
is encoded by: hsa:954
boundary condition: true
is: SBO:0000252
is: Q5SPY7
initial amount: NaN
type: Species
has only substance units: false

metaR LEUKTRD4t
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
product: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
reversible: true
name: leukotriene D4 transport
is described by: ECO:0000269
kinetic law: MODEL1310110064#

metaR 1PPDCRp
product: MODEL1310110064#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
reversible: false

metaR DGULND
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: dehydro-L-gulonate decarboxylase
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110064#

metaR r0590
modifier: MODEL1310110064#
reactant: MODEL1310110064#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110064#

metaM guln c
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB03290
is: CHEBI:13115
initial concentration: 1.0
type: Species
name: L-gulonate
initial amount: NaN

metaM gsn e
name: Guanosine
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00133
has only substance units: false
is: CHEBI:16750
type: Species
is: C00387

metaR PPItm
is described by: ECO:0000134
type: Reaction
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial
reversible: true
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#

metaM accoa m
is: C00024
initial amount: NaN
is: CHEBI:57288
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
constant: false
is: HMDB01206
name: Acetyl-CoA
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR TPI
is described by: ECO:0000134
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reversible: true
type: Reaction
reactant: MODEL1310110064#
name: triose-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.1
is: SBO:0000176
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaR Rtotaltl
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
is: SBO:0000185
type: Reaction
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_25fc26ca_0be3_4dae_9f9d_710fd6f048b8
initial amount: NaN
type: Species
is encoded by: hsa:4704
is: Q16795
is: SBO:0000252
constant: false
initial concentration: NaN
name: NDUFA9
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b0e10799_8228_4883_8ee3_d3c29f4f6c85
is encoded by: hsa:4712
is encoded by: hsa:4713
has part: Q85KV6
has part: F8VQS7
is encoded by: hsa:4538
is encoded by: hsa:4539
is encoded by: hsa:4706
type: Species
is encoded by: hsa:4697
is encoded by: hsa:126328
has part: O95167
has part: Q6FG42
is encoded by: hsa:51079
is: SBO:0000297
has part: Q16718
is encoded by: hsa:4729
has part: Q7GXZ4
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4731
is encoded by: hsa:55967
is encoded by: hsa:4722
has part: Q6IBC4
boundary condition: true
has part: Q7GXZ1
is encoded by: hsa:4716
has part: O14561
has part: Q6IBA0
has part: O00483
is encoded by: hsa:4719
is encoded by: hsa:4709
has part: B7Z792
is encoded by: hsa:4711
is encoded by: hsa:4701
is encoded by: hsa:4541
is encoded by: hsa:4702
has part: O95168
has part: P28331
is encoded by: hsa:4537
is encoded by: hsa:4695
is encoded by: hsa:4698
is encoded by: hsa:4696
has part: P03897
has part: O75489
has part: O43181
is encoded by: hsa:4725
is encoded by: hsa:4726
has part: A8K761
has part: P03905
has part: P56181
is encoded by: hsa:4728
has only substance units: false
is encoded by: hsa:4718
has part: P03915
is encoded by: hsa:7991
is encoded by: hsa:4720
is encoded by: hsa:4710
has part: H7C5B8
is encoded by: hsa:374291
is encoded by: hsa:4715
is encoded by: hsa:4705
has part: O00217
initial amount: NaN
is encoded by: hsa:4536
initial concentration: NaN
has part: P17568
is encoded by: hsa:4707
is encoded by: hsa:4708
has part: Q7GXY9
has part: O95139
has part: O95299
is encoded by: hsa:4700
has part: P19404
has part: Q16795
has part: Q6IB80
is encoded by: hsa:4694
has part: Q9Y6M9
has part: O95169
is encoded by: hsa:4723
is encoded by: hsa:4724
is encoded by: hsa:4714

metaM HC01162 c
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58376
initial concentration: 1.0
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691

metaM Ser Gly Ala X Gly l
initial amount: NaN
is: CHEBI:16347
type: Species
constant: false
is: C00318
initial concentration: 1.0
is: HMDB00062
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: SBO:0000247
has only substance units: false
notes: FORMULA: XH CHARGE: 0
boundary condition: false

metaM gly e
boundary condition: false
type: Species
constant: false
is: C00037
initial amount: NaN
is: CHEBI:3339
name: Glycine
is: SBO:0000247
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false

metaM 3dhguln c
type: Species
constant: false
is: CHEBI:57655
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: HMDB06334
name: 3-dehydro-L-gulonate
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r1544
type: Reaction
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_0935ab7b_bfe9_445b_be0b_d9b653941ffb
is: O95470
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8879
constant: false
type: Species
has only substance units: false
boundary condition: true
name: SGPL1
initial amount: NaN

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_8fc99606_d054_4134_b4f6_a8ca4c087c8b
is encoded by: hsa:1329
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: COX5B
is: Q53YB7

metaM Rtotal l
has only substance units: false
type: Species
notes: FORMULA: CO2FULLR CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: R total
is: CHEBI:52639
constant: false

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
kinetic law: MODEL1310110064#
reversible: false
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction

metaM HC02187 e
constant: false
type: Species
is: CHEBI:28774
initial amount: NaN
name: reverse-triiodthyronine
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r0591
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reversible: true
is described by: ECO:0000000
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
type: Reaction
product: MODEL1310110064#

metaR GLYOX
fast: false
modifier: MODEL1310110064#
name: hydroxyacylglutathione hydrolase
is described by: ECO:0000269
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.6

http://identifiers.org/biomodels.db/MODEL1310110064#_c43b73ee_61c8_41fc_9a19_3ccd259416fe
is encoded by: hsa:2194
is: SBO:0000252
boundary condition: true
name: FASN
is: P49327
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

metaR H2O2tp
name: hydrogen peroxide peroxisomal transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reversible: true
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

metaM amp r
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
is: HMDB00045
is: SBO:0000247
name: AMP
initial amount: NaN
is: C00020
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:456215

metaR S4TASE5ly
fast: false
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.6.12
reversible: true
is described by: ECO:0000000
product: MODEL1310110064#

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR r2055
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM pmtcrn r
name: L-palmitoylcarnitine
is: CHEBI:17490
constant: false
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
is: HMDB00222
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

metaM kynate c
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:58454
is: HMDB00715
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
constant: false
name: kynurenate
has only substance units: false

metaR NAHCO3 HCLt
is described by: ECO:0000269
modifier: MODEL1310110064#
type: Reaction
fast: false
product: MODEL1310110064#
is: SBO:0000185
name: bicarbonate transport (HCl/NaHCO3 exchange)
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
kinetic law: MODEL1310110064#
reversible: true

metaR NDPK1m
product: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110064#
is described by: ECO:0000254
reactant: MODEL1310110064#
is: SBO:0000176
type: Reaction
reversible: true
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_dd44cf9c_ab76_4d80_bc16_01cafb411184
name: GALNT7
is: Q86SF2
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:51809

metaR O2Stn
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110064#
reversible: true
name: superoxide anion transport via diffusion (nucleus)
product: MODEL1310110064#

metaR r0752
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110064#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
reactant: MODEL1310110064#
is: SBO:0000176

metaM nadh c
name: Nicotinamide adenine dinucleotide - reduced
type: Species
initial concentration: 1.0
is: HMDB01487
is: SBO:0000247
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
is: CHEBI:57945
initial amount: NaN
is: C00004

metaR AHCYStd
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
fast: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
name: diffusion of S-Adenosyl-L-homocysteine
product: MODEL1310110064#

metaM succoa m
type: Species
is: SBO:0000247
name: Succinyl-CoA
has only substance units: false
initial concentration: 1.0
is: HMDB01022
is: CHEBI:57292
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
boundary condition: false
constant: false
initial amount: NaN

metaR r0642
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_dac39ffd_0439_4229_a7be_279e0e15d713
is encoded by: hsa:22934
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: RPIA
boundary condition: true
is: P49247

http://identifiers.org/biomodels.db/MODEL1310110064#_57e4bbb0_e477_4004_a110_639c10281a10
is encoded by: hsa:5625
is: O43272
constant: false
initial concentration: NaN
boundary condition: true
name: PRODH
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR AACOAT
product: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.16
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
name: Acetoacetyl-CoA:acetate CoA-transferase

metaR RE1807C
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
name: RE1807
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM CE0713 m
constant: false
is: SBO:0000247
name: 3-oxolinoleoyl-CoA
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: CHEBI:30623
is: HMDB02329
type: Species
initial concentration: 1.0

metaR CHATn
name: Choline O-acetyltransferase
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
modifier: MODEL1310110064#
fast: false
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.6

http://identifiers.org/biomodels.db/MODEL1310110064#_123a46b1_fd65_406f_a232_c985483c1fff
is: Q8N1Q1
is encoded by: hsa:377677
has only substance units: false
name: CA13
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM gly c
type: Species
constant: false
is: C00037
initial amount: NaN
name: Glycine
is: CHEBI:3339
is: SBO:0000247
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM gsn c
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00133
constant: false
has only substance units: false
name: Guanosine
initial concentration: 1.0
is: C00387
boundary condition: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: CHEBI:16750

metaR O2Stm
fast: false
reversible: true
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
name: superoxide anion transport via diffusion (mitochondria)

metaR r0753
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
reactant: MODEL1310110064#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_314b931c_f628_4718_8809_83c6a7aa0908
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51022
initial amount: NaN
name: GLRX2
constant: false
is: Q9NS18

metaR AHCYSte
reversible: true
name: Transport of S-adenosyl-L-homocysteine
fast: false
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR r0641
reactant: MODEL1310110064#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
reversible: true

metaR DALAt2r
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
modifier: MODEL1310110064#
product: MODEL1310110064#
name: D-alanine transport via proton symport
kinetic law: MODEL1310110064#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110064#
reversible: true
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110064#_6cffe6f0_9513_43f0_9d51_9be61b4fee1b
is: Q8IX04
type: Species
is: SBO:0000252
constant: false
name: UEVLD
initial amount: NaN
boundary condition: true
is encoded by: hsa:55293
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_03c5af9a_cbb7_4c88_94be_3a7f664d54d3
name: LGALS13
constant: false
boundary condition: true
type: Species
is encoded by: hsa:29124
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q9UHV8

metaR H2O2tn
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
name: hydrogen peroxide nuclear transport
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it

http://identifiers.org/biomodels.db/MODEL1310110064#_cf505524_5f92_4939_8ad1_b30924fabf13
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6505
boundary condition: true
is: P43005
name: SLC1A1
initial amount: NaN
type: Species

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR NH4t3r
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
name: ammonia transport via proton antiport
fast: false
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_39ebe115_e2de_443a_b48f_e46aaabd3d88
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: HAS1
initial amount: NaN
is: Q8IYH3
is encoded by: hsa:3036
type: Species
has only substance units: false

metaR CYTK2
modifier: MODEL1310110064#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: cytidylate kinase (dCMP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_49df2efb_a09c_4a99_820b_f28ada3fa4ee
constant: false
is encoded by: hsa:1375
name: CPT1B
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q92523

metaR r1757
product: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110064#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#

metaM xan x
is: C00385
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00292
is: CHEBI:17712
type: Species
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
name: Xanthine
boundary condition: false
constant: false
initial concentration: 1.0

metaM lac L e
initial concentration: 1.0
is: HMDB00190
name: (S)-lactate
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
boundary condition: false

metaR MAN1PT2
modifier: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.13
is described by: ECO:0000000
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
reversible: false
name: mannose-1-phosphate guanylyltransferase (GDP)
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176

metaM mlthf c
is: CHEBI:15636
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: 5,10-Methylenetetrahydrofolate
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial concentration: 1.0
boundary condition: false
is: HMDB01533
is: C00143

metaM gal e
has only substance units: false
is: HMDB00143
name: D-Galactose
notes: FORMULA: C6H12O6 CHARGE: 0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:0
type: Species
is: C00124
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_af741ee1_ab9a_4a29_979a_1f933a85dd96
initial amount: NaN
is: SBO:0000252
name: ACSS1
initial concentration: NaN
boundary condition: true
type: Species
is: Q9NUB1
has only substance units: false
is encoded by: hsa:84532
constant: false

metaM uacgam g
constant: false
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial amount: NaN
is: HMDB00290
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57705

http://identifiers.org/biomodels.db/MODEL1310110064#_e887ce6d_5167_4e95_a1d6_2ae128980b54
is: Q9Y6L6
constant: false
type: Species
is encoded by: hsa:10599
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLCO1B1
initial amount: NaN

W3 CDTF: Thu Aug 30 10:22:19 BST 2012

metaM cholcoa x
constant: false
boundary condition: false
type: Species
is: HMDB01374
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57373
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)

metaM glyc S c
constant: false
notes: FORMULA: C3H5O4 CHARGE: 0
name: (S)-Glycerate
is: CHEBI:33871
initial amount: NaN
type: Species
has only substance units: false
is: HMDB06372
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR DCSPTN1COAtx
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
reactant: MODEL1310110064#
type: Reaction
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_51c2b257_2487_4bcd_b0cd_fc1a45210c0d
is: Q7Z725
constant: false
has only substance units: false
initial amount: NaN
name: SLC34A1
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6569

http://identifiers.org/biomodels.db/MODEL1310110064#_46da8236_ed80_4bab_9090_e051bff53741
initial amount: NaN
is encoded by: hsa:30
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q96CA6
has only substance units: false
constant: false
boundary condition: true
name: ACAA1

metaR CYTK3
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (CMP)(GTP)
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_85b5c133_ca35_4c27_a116_2836dd46c854
has only substance units: false
type: Species
is: SBO:0000252
is: P15104
initial amount: NaN
boundary condition: true
is encoded by: hsa:2752
constant: false
initial concentration: NaN
name: GLUL

metaR PROSTGE2t2
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
reactant: MODEL1310110064#
type: Reaction
fast: false
reversible: true
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_df0646e2_f8db_48d6_8d7c_47c27f92f2db
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: ALDH3B1
is: P43353
is encoded by: hsa:221

http://identifiers.org/biomodels.db/MODEL1310110064#_d8c58144_bc7f_42ef_ae87_46038cd821de
name: NME1
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: P15531
is encoded by: hsa:4830
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_6594bf81_caa4_4a6b_8816_d45a2e9d5520
is: Q9H008
boundary condition: true
is encoded by: hsa:64077
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: LHPP

metaR GLUt6
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
is: SBO:0000185
kinetic law: MODEL1310110064#
is described by: ECO:0000269
product: MODEL1310110064#
fast: false
name: Glutamate transport via Na, H symport and K antiport

metaM arachdcoa m
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06523

metaR r1756
reversible: false
kinetic law: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM cspg e l
type: Species
initial amount: NaN
is: HMDB00062
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: CHEBI:16347
initial concentration: 1.0
constant: false
is: C00318
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8

metaR EX gumtchol LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-taurocholic acid complex
type: Reaction

metaM pi g
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00973
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
has only substance units: false

metaR THYOXt
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
fast: false
reactant: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
name: T4 transport via bicarbonate countertransport

metaR PHETHPTOX2
reversible: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.16.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
fast: false

metaM HC02205 e
is: SBO:0000247
has only substance units: false
type: Species
name: prostaglandin-b2
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28099
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f3697063_5fdd_4a59_bb22_595c66e8378f
is encoded by: hsa:284273
is: Q4G1C4
name: ZADH2
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM dcholcoa r
is: CHEBI:28701
constant: false
boundary condition: false
name: chenodeoxycholoyl coenzyme a
type: Species
is: HMDB06292
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_c26e4be5_d9ee_4f1c_9225_e6886bf1ccbf
name: PPA1
initial amount: NaN
boundary condition: true
is: Q15181
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:5464

metaR r0245
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true

metaR DM pnto R
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for (R)-Pantothenate
type: Reaction

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_c6b0b5b3_54c7_48fe_9bb8_4edb924a6e29
initial concentration: NaN
name: APRT
is: P07741
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:353
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM HC01602 c
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
has only substance units: false
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
boundary condition: false
constant: false
is: C00234
is: SBO:0000247

metaR NTD7
is: SBO:0000176
reversible: false
reactant: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
type: Reaction
name: 5'-nucleotidase (AMP)
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110064#

metaR ASNtN1
reversible: true
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110064#
type: Reaction
name: Asparagine transport (Na, H coupled)
modifier: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR r2532
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000

metaR CYTK1
reversible: true
fast: false
type: Reaction
name: cytidylate kinase (CMP)
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_8cff84fc_7913_41c4_bec4_a746586ccc87
is: SBO:0000252
is encoded by: hsa:6521
boundary condition: true
has only substance units: false
is: P02730
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: SLC4A1

http://identifiers.org/biomodels.db/MODEL1310110064#_c93fef56_a12c_40b7_9bc3_3316944e51f7
initial amount: NaN
name: PLCB4
is: Q15147
constant: false
boundary condition: true
is encoded by: hsa:5332
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaR r0399
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110064#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_adf02ddb_e700_494a_91e9_db5bc4ee8949
initial concentration: NaN
is encoded by: hsa:9963
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9UHI7
is: SBO:0000252
name: SLC23A1

metaR r0246
is: SBO:0000176
kinetic law: MODEL1310110064#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
reversible: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#

metaM pi e
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: C00009
name: hydrogenphosphate
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
is: HMDB00973
is: CHEBI:43474

metaR RE0944E
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
product: MODEL1310110064#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0944
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110064#_e93127c3_3afb_406e_ba78_77e1ec18bb70
is encoded by: hsa:LOC374569
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: _LOC374569_1_e
constant: false
initial amount: NaN

metaR SPHS1Ptr
is: SBO:0000185
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
fast: false
name: sphingosine-1-phosphate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
reversible: true
type: Reaction
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_5bde8d64_a6c9_4042_ae52_a84844300a53
is encoded by: hsa:27034
is: Q6ZWP6
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: ACAD8
initial concentration: NaN
type: Species
constant: false

metaR NTD8
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
product: MODEL1310110064#
reversible: false
name: 5'-nucleotidase (dGMP)
reactant: MODEL1310110064#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
kinetic law: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_35c8849a_038e_4770_86ff_43f9f851bee7
initial concentration: NaN
name: _AI656480_1_m
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:AI656480
is: SBO:0000252
initial amount: NaN

metaM HC02205 c
constant: false
is: CHEBI:28099
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: prostaglandin-b2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
type: Species

metaR r1546
kinetic law: MODEL1310110064#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM i e
is: HMDB12238
boundary condition: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
name: iodide
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16382
initial concentration: 1.0
type: Species

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_348562bc_34cb_4b67_a0aa_876e464b3d2a
initial amount: NaN
constant: false
boundary condition: true
name: _FLJ44968_1_m
has only substance units: false
type: Species
is encoded by: hsa:FLJ44968
initial concentration: NaN
is: SBO:0000252

metaR BDHm
type: Reaction
fast: false
modifier: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.30

metaR r2535
reactant: MODEL1310110064#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_2f879aa8_0a6f_4cd6_ac2b_329acd1c67c2
is: B1AK53
is encoded by: hsa:83715
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: ESPN

metaR CYTK6
reversible: true
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (CMP,CTP)
type: Reaction
is: SBO:0000176
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110064#

metaM CE5854 e
constant: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: HMDB02710
is: CHEBI:27485
name: gama-CEHC-glucuronide
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

metaR TRDR
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.8.1.9
type: Reaction
is described by: ECO:0000269
product: MODEL1310110064#
modifier: MODEL1310110064#
reversible: false
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
fast: false

metaR r2321
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110064#

metaM nad c
initial amount: NaN
name: Nicotinamide adenine dinucleotide
is: C00003
type: Species
is: http://identifiers.org/pubchem.compound/3305
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57540
is: HMDB00902

metaR r0392
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
fast: false
reactant: MODEL1310110064#
reversible: true
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110064#_63de16bf_bbfa_4a60_8619_c0f7e086f604
constant: false
is encoded by: hsa:3157
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: HMGCS1
type: Species
is: Q01581
has only substance units: false
boundary condition: true

metaM ade c
is: CHEBI:16708
boundary condition: false
type: Species
is: HMDB00034
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Adenine
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: C00147
is: SBO:0000247

metaM CE5586 c
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
type: Species
initial amount: NaN
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:58732

metaR r1547
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000

metaM ade e
is: CHEBI:16708
is: HMDB00034
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
name: adenine
constant: false
type: Species

metaR MI1PP
is: SBO:0000176
reversible: false
name: myo-inositol 1-phosphatase
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
product: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.3.25

metaR CYTK7
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
fast: false
name: cytidylate kinase (CMP,UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110064#

metaR r2534
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110064#

metaM ac e
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30089
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
name: acetate
has only substance units: false
constant: false
is: HMDB00042

metaM pi c
type: Species
has only substance units: false
is: CHEBI:43474
is: C00009
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
is: HMDB00973
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: hydrogenphosphate

metaR HACD1m
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reactant: MODEL1310110064#
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110064#_a395e0e9_aa6e_4e46_b5f7_40b933b48a8b
initial amount: NaN
type: Species
is: Q7GXZ1
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:4541
name: ND6
initial concentration: NaN

metaR r2320
is: SBO:0000185
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_e4ffada7_5eae_43b7_985b_3cd2d0e48abd
type: Species
name: NDUFA11
initial amount: NaN
is encoded by: hsa:126328
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is: C9JT23

http://identifiers.org/biomodels.db/MODEL1310110064#_98135039_18d2_4757_8424_661e2ccfae94
initial amount: NaN
name: ADA
initial concentration: NaN
constant: false
is: P00813
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:100
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_6fe1b6ba_6c6b_4aae_921c_fb8bc219f2eb
boundary condition: true
is: P34059
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:2588
name: GALNS

metaR r0393
modifier: MODEL1310110064#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:

metaR LCADi D
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is: SBO:0000176
fast: false
name: lactaldehyde dehydrogenase
kinetic law: MODEL1310110064#
reversible: false
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110064#_5c0cf683_99f9_4998_8f11_5031dd2bf824
is encoded by: hsa:94005
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: Q8NBL9
initial amount: NaN
boundary condition: true
name: PIGS
has only substance units: false

metaR PPA
is described by: ECO:0000269
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
fast: false
is: SBO:0000176
name: inorganic diphosphatase
modifier: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction

metaM i c
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
boundary condition: false
name: iodide
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16382

metaR r2323
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
type: Reaction
reversible: true
kinetic law: MODEL1310110064#

metaR HACD9m
is: SBO:0000176
reactant: MODEL1310110064#
is described by: ECO:0000134
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
kinetic law: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
reversible: true
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial

metaR r1548
type: Reaction
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gal c
is: HMDB00143
name: D-Galactose
is: C00124
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0
is: CHEBI:0

metaR DOPAt4 2 r
fast: false
name: Dopamine reversible transport in via sodium symport (1:2)
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_ae2b5d03_2c0f_4331_b4c3_d724f975e333
is: P00326
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: ADH1C
is: SBO:0000252
is encoded by: hsa:126
boundary condition: true
constant: false

metaR CYTK4
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
modifier: MODEL1310110064#
fast: false
name: cytidylate kinase (dCMP)(GTP)
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is: SBO:0000176
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#

metaR r2537
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
name: Utilized transport

metaR ABTti
is: SBO:0000185
reversible: false
name: L-arabinitol transport via passive diffusion
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000

metaM cs b l
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
type: Species
constant: false
has only substance units: false
is: C00318
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: HMDB00062
initial concentration: 1.0
is: CHEBI:16347

metaR r0394
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110064#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true

metaR r0022
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
is: SBO:0000176
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110064#
product: MODEL1310110064#
fast: false

metaR UAGALDP
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
name: UDP-N-acetylgalactosamine diphosphorylase
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110064#

metaR r2322
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ppcoa c
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: C00100
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
name: Propanoyl-CoA
is: CHEBI:57392
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_4e587137_6afb_4625_b2d3_c7830a22f408
type: Species
constant: false
initial concentration: NaN
name: _AU149534_1_m
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AU149534
boundary condition: true

metaR NADPHtru
product: MODEL1310110064#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
name: NADPH transporter, endoplasmic reticulum
type: Reaction

metaM mem2emgacpail hs r
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: HMDB03125
initial concentration: 1.0
boundary condition: false
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol (M4B)
constant: false
is: CHEBI:16240
type: Species

metaR P5CRm
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
name: pyrroline-5-carboxylate reductase (m)
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is: SBO:0000176
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110064#
type: Reaction
fast: false
is described by: ECO:0000304

metaR r1549
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#

metaR CYTK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP)
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110064#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110064#_a989aa8f_15a0_4aaf_a1ff_e098f10a30bd
name: _AI990637_1_x
has only substance units: false
boundary condition: true
is encoded by: hsa:AI990637
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ea59b537_69f5_4fcd_94b4_f4d221b9b11d
boundary condition: true
is: G3V4L5
has only substance units: false
initial concentration: NaN
name: SLC25A21
constant: false
is: SBO:0000252
is encoded by: hsa:89874
initial amount: NaN
type: Species

metaM ac c
is: HMDB00042
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30089
boundary condition: false
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
initial amount: NaN

metaR r0660
is: SBO:0000176
reactant: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_46f59f7f_2521_44d7_85c2_8b095774a090
is: SBO:0000252
type: Species
has only substance units: false
name: DPYSL2
initial concentration: NaN
constant: false
is: B4DR31
boundary condition: true
initial amount: NaN
is encoded by: hsa:1808

http://identifiers.org/biomodels.db/MODEL1310110064#_843a8eee_178a_47af_b953_3017f4cf6b21
type: Species
is: SBO:0000252
is: P31350
name: RRM2
initial concentration: NaN
constant: false
is encoded by: hsa:6241
initial amount: NaN
boundary condition: true
has only substance units: false

metaM cspg e e
is: HMDB00300
is: CHEBI:17568
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00106
boundary condition: false
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
type: Species

metaM fe2 c
has only substance units: false
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
is: HMDB00692
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:29033
name: Fe2+
is: C00023
initial concentration: 1.0

metaM dgsn m
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00085
name: Deoxyguanosine
has only substance units: false
type: Species
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: CHEBI:17172
boundary condition: false

metaR r0021
reactant: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
is: SBO:0000176
product: MODEL1310110064#
fast: false
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7

metaR CYTD
name: cytidine deaminase
kinetic law: MODEL1310110064#
is: SBO:0000176
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.5
is described by: ECO:0000254
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
reversible: false

metaM cs a l
is: SBO:0000247
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: HMDB00062
constant: false
is: C00318
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: CHEBI:16347

metaR CO2tm
reversible: true
name: CO2 transport (diffusion), mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is: SBO:0000185
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#

metaR H2MTer U
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
fast: false
name: H2 mannosyltransferase, endoplasmic reticulum
reversible: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction

metaR 5ADTSTSTERONESte
reversible: true
name: sulfonated testosterone transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is: SBO:0000185
product: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_07561d9f_29a6_4a98_b023_5fda33bd4155
is: Q96I99
name: SUCLG2
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:8801
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR FAOXC161802m
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
name: Beta oxidation fatty acid
is described by: ECO:0000269
is: SBO:0000176
reversible: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110064#_dc7dfb8f_76ec_4619_b78e_35c3c16a9b7f
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM acetol c
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB06961
has only substance units: false
initial amount: NaN
is: CHEBI:27957
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
type: Species
boundary condition: false
name: hydroxyacetone

http://identifiers.org/biomodels.db/MODEL1310110064#_76507f45_39a9_404d_8d66_21f7c8ba71b5
initial amount: NaN
name: _M68895_1_c
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:M68895

metaM lnlc c
is: CHEBI:30245
type: Species
name: linoleate
is: HMDB00673
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
is: SBO:0000247

metaM core6 l
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial concentration: 1.0
is: CHEBI:12936
name: Core 6
is: HMDB00143
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false

metaM dcholcoa x
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
constant: false
is: HMDB06292
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_5a951e94_ad03_4df7_b63d_274fc306d2ed
constant: false
initial concentration: NaN
is encoded by: hsa:5052
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: PRDX1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_70c39f4c_d41f_467d_8147_03c905477fb9
is: Q99808
is encoded by: hsa:2030
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC29A1
initial concentration: NaN
has only substance units: false

metaR ASPNATm
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
name: aspartate N-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM

metaR r2325
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110064#
type: Reaction
reversible: true
reactant: MODEL1310110064#

metaM nh4 x
type: Species
is: CHEBI:28938
is: C01342
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
name: Ammonium
is: HMDB00051
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_ecb2c7e2_dd59_431c_b61c_f02c2456ea01
has only substance units: false
type: Species
boundary condition: true
is: Q92947
initial amount: NaN
is: SBO:0000252
constant: false
name: GCDH
is encoded by: hsa:2639
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_50bf2f64_d366_4603_8a12_71e713333864
constant: false
is: Q6FH11
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3162
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: HMOX1

metaM 5adtststerone c
is: HMDB02961
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330

http://identifiers.org/biomodels.db/MODEL1310110064#_41fd5ff6_48ce_40e5_8bb4_9901719976c4
type: Species
has only substance units: false
boundary condition: true
is: Q9H845
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:28976
name: ACAD9
initial amount: NaN

metaR r1298
reversible: false
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_20cefa4c_6a68_4074_9728_4bd2fdf11bdf
type: Species
is encoded by: hsa:130
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ADH6
constant: false
is: P28332

http://identifiers.org/biomodels.db/MODEL1310110064#_727ce33e_d68e_4f00_abcb_f7d9bcdabaf9
constant: false
type: Species
initial amount: NaN
is: Q5JRA6
is encoded by: hsa:375056
has only substance units: false
boundary condition: true
initial concentration: NaN
name: MIA3
is: SBO:0000252

metaR GLYCLTDy
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:2689175 NOTES:JLR
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
name: Glycolate dehydrogenase (NADP)
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.79

metaR r0027
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.39
is described by: ECO:0000000
modifier: MODEL1310110064#
is: SBO:0000176
fast: false
reversible: true
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
kinetic law: MODEL1310110064#

metaR 25HVITD3c
name: 1-alpha hydroxylation of 25-hydroxy vitamin D
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1594.1) SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 2 AUTHORS: Cross HS, Peterlik M, Reddy GS, Schuster I. (1997). The Journal of Steroid Biochemistry and Molecular Biology 62: 21-8, PMID: 15208365, PMID: 15208365, PMID: 11158062. NOTES:intestine has been shown to be aonther extra renal site for Vit D production. Vit D has potential to check malignancies in the caco-2 cells. 25-hydroxy D3 can also undergo oxidation to produce 1,23 di-hydroxyD3. subcellular localization is mentioned as both mitochondrial and cytosolic. 1,25-dihydroxy-vitamin D helps in maintaining normal epithemium, proliferation and growth and prevents colon cancer (PMID: 19667168, PMID: 14585316).
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.13

metaR r2324
type: Reaction
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false

metaR XANDp
is: SBO:0000176
reversible: false
is described by: ECO:0000269
product: MODEL1310110064#
name: xanthine dehydrogenase, peroxisomal
fast: false
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES:Acts on a variety of purines and aldehydes. The animal enzyme can be interconverted to EC 1.1.3.22 xanthine oxidase (the oxidase form). IT
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.17.1.4
reactant: MODEL1310110064#

metaR r2398
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_15dab4a5_9cfd_4a36_ac98_c952c58de48e
has only substance units: false
type: Species
constant: false
name: ALDH3A1
is: P30838
boundary condition: true
is: SBO:0000252
is encoded by: hsa:218
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ae6dd6d2_f449_4e4e_b739_07a7dfa45fd7
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: _AA502753_1_m
type: Species
initial concentration: NaN
is encoded by: hsa:AA502753
is: SBO:0000252

metaR FAOXC180
modifier: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is described by: ECO:0000269
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_f3558251_ed98_4f92_bab6_c228e3c9609a
is: Q8TE04
constant: false
name: PANK1
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:53354
initial concentration: NaN

metaM lnlc e
is: CHEBI:30245
is: SBO:0000247
is: HMDB00673
has only substance units: false
initial amount: NaN
name: linoleate
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR RE1517M
name: RE1517
modifier: MODEL1310110064#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction

metaR CYTK8
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (CMP,dATP)
fast: false
is: SBO:0000176
reactant: MODEL1310110064#

metaR r0179
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
fast: false
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_d4a15b66_91c7_4cc7_8049_ef78823c2580
has only substance units: false
type: Species
name: NDUFB1
initial amount: NaN
is: O75438
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4707

metaR r2327
is described by: ECO:0000000
reactant: MODEL1310110064#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_ce8758b7_be2d_4504_84db_ad6e529912bf
initial amount: NaN
boundary condition: true
has only substance units: false
name: NDUFC1
type: Species
initial concentration: NaN
is encoded by: hsa:4717
is: SBO:0000252
constant: false
is: O43677

http://identifiers.org/biomodels.db/MODEL1310110064#_b9646a97_7c28_4c85_af71_bafd37de6a93
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: SLC24A2
is encoded by: hsa:25769
is: Q9UI40
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_ce174eec_f8b6_496b_bfbc_3fadedafa15e
is: E9PDK1
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:83697
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: SLC4A9

http://identifiers.org/biomodels.db/MODEL1310110064#_b442e2fc_bd47_4dc7_98af_3112ded1ce6a
is: P00352
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:216
type: Species
name: ALDH1A1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_cb384d93_df4a_4df7_94a5_a39b161469cd
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9ULC5
is encoded by: hsa:51703
name: ACSL5
has only substance units: false
is: SBO:0000252

metaR PPDOy
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaM 5aop m
type: Species
initial amount: NaN
name: 5-Amino-4-oxopentanoate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17549
is: C00430
has only substance units: false
is: HMDB01149
boundary condition: false
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430

http://identifiers.org/biomodels.db/MODEL1310110064#_69b12446_ad42_4a4f_985a_e6d73fbc43a9
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: P03897
is encoded by: hsa:4537
constant: false
boundary condition: true
is: SBO:0000252
name: ND3

metaR ADEt
is: SBO:0000185
type: Reaction
fast: false
name: adenine reversible transport, cytosol
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#

metaR RE3346C
is described by: ECO:0000000
product: MODEL1310110064#
name: RE3346
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
reactant: MODEL1310110064#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110064#

metaR N4Tg
is described by: ECO:0000000
is: SBO:0000176
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
type: Reaction
reactant: MODEL1310110064#
reversible: false

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_81344dce_bb1b_4859_8424_541fa0a0cb1c
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: NDUFS3
is: O75489
type: Species
is encoded by: hsa:4722
is: SBO:0000252

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM hdca r
name: Hexadecanoate (n-C16:0)
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: C00249
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:7896
initial concentration: 1.0
is: HMDB00220

metaM hcys L c
name: L-homocysteine
initial amount: NaN
is: CHEBI:17588
constant: false
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00742
boundary condition: false
has only substance units: false

metaM arachdcoa c
initial amount: NaN
has only substance units: false
is: CHEBI:57368
initial concentration: 1.0
is: HMDB06523
name: arachidonoyl-CoA(4-)
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

metaR CYTK9
name: cytidylate kinase (CMP,dCTP)
modifier: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269

metaR r0178
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
type: Reaction
product: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000176
reactant: MODEL1310110064#
modifier: MODEL1310110064#

metaR r2326
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110064#
type: Reaction

metaR CYTDtm
is described by: ECO:0000269
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
type: Reaction
fast: false
name: cytidine facilated transport in mitochondria
reversible: true

metaR CMPSAS
is version of: http://identifiers.org/ec-code/2.7.7.43
modifier: MODEL1310110064#
product: MODEL1310110064#
fast: false
is: SBO:0000176
name: CMP sialic acid synthase
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#

metaR PGI
kinetic law: MODEL1310110064#
name: glucose-6-phosphate isomerase
is: SBO:0000176
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.9
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
fast: false

metaM maltttr e
is: SBO:0000247
constant: false
is: C02052
is: HMDB01296
name: Maltotetraose
initial amount: NaN
has only substance units: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
type: Species
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5141

http://identifiers.org/biomodels.db/MODEL1310110064#_453239ea_a28a_4201_9a05_752cc199fdad
has only substance units: false
constant: false
is encoded by: hsa:8659
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P30038
type: Species
is: SBO:0000252
name: ALDH4A1

metaR PPDOx
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
reversible: false
reactant: MODEL1310110064#
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_d276d96d_c017_4f3a_a6f7_2304304c033a
name: BPNT1
is: O95861
is encoded by: hsa:10380
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_cfc4a99b_1d3d_4ee9_a417_36e8bb391b0b
boundary condition: true
is: Q6PCB7
initial amount: NaN
name: SLC27A1
is encoded by: hsa:376497
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaM HC02202 e
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
constant: false
name: prostaglandin A1(1-)
initial concentration: 1.0
is: CHEBI:57398
type: Species

metaR r2392
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM datp c
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0
initial amount: NaN
type: Species
name: dATP
is: C00131
boundary condition: false
is: CHEBI:61404
constant: false
is: HMDB01532
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_88bc40b1_39f0_4cf3_9597_6d5b554682d3
type: Species
is encoded by: hsa:28976
boundary condition: true
is: SBO:0000252
is: Q9H845
constant: false
name: ACAD9
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r0926
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
is described by: ECO:0000000
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_bc182a59_1e57_4451_843e_49ed3b13a49a
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: NAE1
is: A8MU28
has only substance units: false
boundary condition: true
is encoded by: hsa:8883
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_10386c3b_aa33_4d2a_b758_7c0e729c0f26
name: ND4L
constant: false
is: SBO:0000252
is: Q7GXZ4
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4539

metaR r2329
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_b3f21e8c_4af3_4230_ba0f_7b7c8c5fd603
is encoded by: hsa:4705
constant: false
has only substance units: false
is: O95299
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: NDUFA10
type: Species

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR CITt4 4
product: MODEL1310110064#
modifier: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reactant: MODEL1310110064#
name: citrate transport via sodium symport
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: true
is described by: ECO:0000006

metaM dttp e
is: SBO:0000247
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01342
type: Species
initial concentration: 1.0
name: dTTP(4-)

W3 CDTF: Thu Aug 30 10:22:13 BST 2012

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM hdca l
type: Species
is: CHEBI:7896
is: HMDB00220
initial concentration: 1.0
name: palmitate
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaM HC01405 m
is: CHEBI:28632
has only substance units: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
name: (S)-Hydroxyoctanoyl-CoA
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR ACACt2
reversible: true
kinetic law: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
name: acetoacetate transport via proton symport
type: Reaction
fast: false
product: MODEL1310110064#

metaM cs c deg2 l
has only substance units: false
is: CHEBI:15748
type: Species
initial concentration: 1.0
is: HMDB00127
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2
constant: false

metaR r1109
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: true
fast: false
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is: SBO:0000176

metaR MTHFC
product: MODEL1310110064#
reversible: true
modifier: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.5
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
is described by: ECO:0000134
name: methenyltetrahydrofolate cyclohydrolase
fast: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_b26739fc_c676_4227_b3a1_20b7d25cd28f
name: GGH
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8836
constant: false
is: Q92820
has only substance units: false
boundary condition: true

metaM CE5236 n
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
has only substance units: false
initial amount: NaN
is: CHEBI:28002
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952
type: Species

metaR GLYCTO1p
is described by: ECO:0000269
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.3.15
is: SBO:0000176
modifier: MODEL1310110064#
name: Glycolate oxidase, peroxisome
reversible: false
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
kinetic law: MODEL1310110064#
fast: false

metaM Nacasp c
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: N-acetyl-L-aspartate(2-)
is: SBO:0000247
constant: false
is: CHEBI:16953
type: Species
is: HMDB00812

metaR r2328
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110064#
reversible: true
is: SBO:0000185

metaR r0728
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false

metaM core6 g
type: Species
constant: false
boundary condition: false
is: C04383
notes: FORMULA: C16H27N2O10X CHARGE: 0
name: Core 6
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM dhlam m
has only substance units: false
is: CHEBI:17694
boundary condition: false
name: dihydrolipoamide
type: Species
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
is: HMDB00985
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247

metaR MGSA
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
reversible: false
name: methylglyoxal synthase
kinetic law: MODEL1310110064#

metaM fe2 m
constant: false
boundary condition: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial amount: NaN
has only substance units: false
is: CHEBI:29033
is: HMDB00692
type: Species
is: SBO:0000247
name: Fe2+
initial concentration: 1.0
is: C00023

metaR S2TASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110064#
product: MODEL1310110064#
reversible: false
type: Reaction
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: iduronate-2-sulfatase, lysosomal
kinetic law: MODEL1310110064#

metaM ac m
initial concentration: 1.0
name: acetate
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:30089
boundary condition: false
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species

W3 CDTF: Thu Aug 30 10:22:13 BST 2012

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_1a5e024c_f39e_4095_aa41_afcc05bfe730
name: _AV713053_1_m
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AV713053
constant: false
initial amount: NaN
is: SBO:0000252

metaR BMTer U
modifier: MODEL1310110064#
name: B mannosyltransferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
product: MODEL1310110064#
fast: false

metaR r2394
kinetic law: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110064#

metaM cit m
is: SBO:0000247
is: C00158
type: Species
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
initial amount: NaN
has only substance units: false
name: Citrate
boundary condition: false
is: CHEBI:16947
initial concentration: 1.0

metaM HC02202 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: prostaglandin A1(1-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57398

metaR FAOXC4C2m
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C4-->C2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_4afab794_077d_4c32_9bbf_55a9ebb62b48
has only substance units: false
is encoded by: hsa:26227
is: O43175
constant: false
type: Species
is: SBO:0000252
name: PHGDH
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM dttp c
name: dTTP
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: C00459
initial amount: NaN
is: HMDB01342
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:37568

http://identifiers.org/biomodels.db/MODEL1310110064#_9e521904_d82d_4141_b1c0_1df5e28b8f02
has only substance units: false
is encoded by: hsa:3628
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: INPP1
is: P49441
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_8fb2a4f5_c487_42b7_a941_bf9470c4f6f9
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:100287639
constant: false
boundary condition: true
initial concentration: NaN
name: _100287639_1_c

http://identifiers.org/biomodels.db/MODEL1310110064#_b4ce4e12_3c59_4527_bd56_b6178c1104e8
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _R51273_1_c
constant: false
is encoded by: hsa:R51273

metaR FAOXC200180m
reversible: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction

metaR r1291
type: Reaction
fast: false
name: Postulated transport reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000

metaR PGK
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
name: phosphoglycerate kinase
fast: false
reactant: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.2.3

metaM lac L c
type: Species
has only substance units: false
is: HMDB00190
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
is: CHEBI:16651

metaM 3odcoa m
initial amount: NaN
has only substance units: false
constant: false
is: HMDB03939
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
name: 3-Oxodecanoyl-CoA
initial concentration: 1.0
is: CHEBI:28528

http://identifiers.org/biomodels.db/MODEL1310110064#_f8ca304e_5c4f_4e11_afae_c86a6d78e0c3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI971036
is: SBO:0000252
initial amount: NaN
name: _AI971036_1_m
type: Species
constant: false
boundary condition: true

metaR CMPACNAtn
is described by: ECO:0000000
name: CMP-Sia nuclear export
reversible: false
kinetic law: MODEL1310110064#
is: SBO:0000185
fast: false
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

W3 CDTF: Thu Aug 30 10:22:19 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110064#_e02593ec_e828_4711_bc52_c365df9614e3
is encoded by: hsa:6528
boundary condition: true
constant: false
initial amount: NaN
name: SLC5A5
initial concentration: NaN
type: Species
has only substance units: false
is: Q92911
is: SBO:0000252

metaR r0242
reversible: true
is: SBO:0000176
reactant: MODEL1310110064#
type: Reaction
fast: false
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaM 5adtststerone e
has only substance units: false
is: HMDB02961
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
constant: false
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR RE0915E
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
name: RE0915
is: SBO:0000176
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_7b59bb81_a9cd_4cb8_ab36_6e377c9b6ab4
is: Q8TE04
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:53354
name: PANK1

http://identifiers.org/biomodels.db/MODEL1310110064#_b8c24019_de8b_4625_a2af_2611805b938a
type: Species
is: O75251
is: SBO:0000252
name: NDUFS7
is encoded by: hsa:374291
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM gal l
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: D-galactose
type: Species

metaR r2395
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
kinetic law: MODEL1310110064#
type: Reaction
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaR CITt4 2
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
name: citrate transport via sodium symport
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
is described by: ECO:0000269

metaR SRTNt6 2 r
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
fast: false
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
modifier: MODEL1310110064#
product: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_b5f427f9_c4bc_4d33_88ad_e4a491668dc3
constant: false
type: Species
name: CPT1A
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1374
is: Q8WZ48
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_f055760a_f05b_4e94_b2fe_d4302862ce42
is: SBO:0000252
is: O95674
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:8760
name: CDS2
boundary condition: true

metaM cholcoa r
is: CHEBI:57373
type: Species
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: choloyl-CoA(4-)
has only substance units: false
constant: false
is: SBO:0000247

metaM uacgam r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
is: CHEBI:57705
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: HMDB00290
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_a5bc3eba_9531_4bbb_b1f9_1af4ff1b7d7d
boundary condition: true
is encoded by: hsa:10991
is: SBO:0000252
name: SLC38A3
has only substance units: false
initial amount: NaN
is: Q99624
constant: false
initial concentration: NaN
type: Species

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_3ace8f6f_0034_4a24_b9cd_8428719a232d
has only substance units: false
is: P48751
initial amount: NaN
constant: false
name: SLC4A3
is encoded by: hsa:6508
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_573fdc03_fc41_4659_b8c5_0120ca9bd448
is: Q99798
initial concentration: NaN
type: Species
has only substance units: false
name: ACO2
initial amount: NaN
is encoded by: hsa:50
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_633561ef_a6ca_4648_a989_40db7b8978a1
is encoded by: hsa:1120
initial concentration: NaN
is: SBO:0000252
is: A0PJM6
initial amount: NaN
constant: false
boundary condition: true
name: CHKB
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_4f7395a1_3679_496f_afdf_a5703bca2f4c
constant: false
boundary condition: true
name: SUCLG1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: P53597
is encoded by: hsa:8802

metaR r0724
type: Reaction
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_67552bce_019b_4ffc_9d6e_fd770de66740
has only substance units: false
is encoded by: hsa:5091
is: SBO:0000252
is: P11498
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: PC
initial concentration: NaN

metaR r2106
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110064#
product: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM rib D c
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: HMDB00283
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16988
type: Species
name: D-ribose

metaR H6ET3er
is version of: http://identifiers.org/ec-code/2.7.8.1
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
kinetic law: MODEL1310110064#
fast: false
type: Reaction
reversible: false
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
product: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_02089a8c_0454_48c5_91ae_20d903d2bd22
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:3283
initial amount: NaN
is: SBO:0000252
is: P14060
name: HSD3B1
has only substance units: false

metaR THRGLYexR
reversible: true
product: MODEL1310110064#
name: L-threonine/glycine reversible exchange
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
modifier: MODEL1310110064#

metaR RE0512M
reversible: true
fast: false
modifier: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110064#
name: RE0512
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_1062030d_77cc_4a3a_ae4e_c1bba6a431f6
is: P49619
initial amount: NaN
type: Species
name: DGKG
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1608

metaM 3sala c
name: 3-Sulfino-L-alanine
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00606
constant: false
boundary condition: false
is: CHEBI:61085
has only substance units: false

metaM 34hpp c
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: HMDB00707
boundary condition: false
type: Species
is: CHEBI:36242
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_60fab57a_9c7a_48b2_93b9_d5104ce8170f
has only substance units: false
is: Q9NYR8
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: RDH8
is encoded by: hsa:50700

metaM CE4876 r
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
initial amount: NaN
type: Species
name: delta12-Prostaglandin J2
boundary condition: false
is: CHEBI:12947

metaR r2107
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110064#
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110064#

metaM arachcoa m
is: HMDB04258
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:15527
name: arachidyl coenzyme A
type: Species
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_5d83dab2_3f23_4a70_b230_35fcc9d150b0
has only substance units: false
boundary condition: true
is: Q8N142
type: Species
is encoded by: hsa:122622
initial concentration: NaN
initial amount: NaN
name: ADSSL1
is: SBO:0000252
constant: false

metaR ACACT1r
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_9d549aa6_1a22_43e3_b5b2_a7289cf56d10
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:64087
has part: Q96RQ3
type: Species
is: SBO:0000297
constant: false
initial concentration: NaN
is encoded by: hsa:56922
has part: Q9HCC0
name: MCCC1:MCCC2

http://identifiers.org/biomodels.db/MODEL1310110064#_f40ced5b_0b6d_4a9f_89c3_8f0cda04d1a5
is encoded by: hsa:2593
constant: false
initial amount: NaN
initial concentration: NaN
name: GAMT
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaR RPI
reactant: MODEL1310110064#
fast: false
name: ribose-5-phosphate isomerase
modifier: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/5.3.1.6
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_946c3dbc_0fd4_4808_b151_a8ebabc8b901
is encoded by: hsa:U52111
name: _U52111_1_c
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaR PROSTGE2t
is: SBO:0000185
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: prostaglandin transport via bicarbonate countertransport

metaM xylu L c
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial amount: NaN
is: HMDB00751
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:17399
constant: false
is: SBO:0000247
name: L-xylulose

metaM nh4 m
boundary condition: false
has only substance units: false
is: CHEBI:28938
is: SBO:0000247
name: Ammonium
initial concentration: 1.0
initial amount: NaN
is: C01342
type: Species
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_6feb967b_d5b2_452e_84f7_2ee23c84590c
is encoded by: hsa:343
initial amount: NaN
initial concentration: NaN
is: O94778
has only substance units: false
is: SBO:0000252
name: AQP8
boundary condition: true
constant: false
type: Species

metaR r2108
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_466b6bfd_38c4_4aa9_9c46_09d0f002d453
boundary condition: true
is encoded by: hsa:AI090874
type: Species
name: _AI090874_1_c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaR r0726
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110064#
type: Reaction
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaR ARACHCPT1
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110064#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110064#_3aa19fd6_5f79_4bf1_8d4a_0dd8d50286a5
constant: false
initial concentration: NaN
is: P15309
type: Species
has only substance units: false
name: ACPP
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_c67d5299_2fab_4645_b07e_f98d887b5069
is: SBO:0000252
is encoded by: hsa:3033
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
name: HADH
is: Q16836
initial concentration: NaN
constant: false

metaR RE1531M
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110064#
name: RE1531
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r0170
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110064#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110064#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21

metaM 13dpg c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57604
name: 3-Phospho-D-glyceroyl phosphate
is: C00236
type: Species
is: http://identifiers.org/pubchem.compound/3535
is: HMDB01270
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236

metaM rib D e
name: D-ribose
constant: false
initial amount: NaN
is: HMDB00283
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16988
has only substance units: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119

metaR PUNP2
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
fast: false
modifier: MODEL1310110064#
reversible: true
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is: SBO:0000176
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_fd89da62_915a_4669_979a_5c2f3335281d
is encoded by: hsa:4695
is: O43678
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NDUFA2
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_030b1a7e_39b8_497f_baf1_d0f77ff9b557
is encoded by: hsa:1738
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P09622
type: Species
constant: false
boundary condition: true
name: DLD

http://identifiers.org/biomodels.db/MODEL1310110064#_dd9aa8ee_bf79_4c86_b6e2_5e42feb734a7
name: SLCO2A1
constant: false
type: Species
is: SBO:0000252
is: Q92959
boundary condition: true
is encoded by: hsa:6578
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_473910a9_859b_49e9_9ef9_4671fe746b05
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: B7Z4Y6
is encoded by: hsa:249
name: ALPL
is: SBO:0000252
constant: false
initial concentration: NaN

metaM gdpmann c
initial amount: NaN
is: HMDB01163
constant: false
type: Species
name: GDP-alpha-D-mannose(2-)
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57527

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM hmbil c
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
is: HMDB01137
is: CHEBI:57845
is: SBO:0000247
type: Species
is: C01024
initial amount: NaN
has only substance units: false
name: Hydroxymethylbilane

metaR CDS
is version of: http://identifiers.org/ec-code/2.7.7.41
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
name: phosphatidate cytidylyltransferase
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_537c1b96_859e_4f98_a480_1f1b4dc4f393
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2348
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: FOLR1

metaR r1821
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#

metaR r2109
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
reversible: true
is described by: ECO:0000000

metaR PUNP1
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
modifier: MODEL1310110064#
name: purine-nucleoside phosphorylase (Adenosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_fd4e853c_1752_4a9f_ba7f_dfe86050bb9d
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: P00441
name: SOD1
is encoded by: hsa:6647
boundary condition: true
is: SBO:0000252
type: Species

metaR DESAT22 1p
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110064#

metaR GGH 10FTHF7GLUe
fast: false
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
type: Reaction
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR 7DHCHSTEROLtr
reactant: MODEL1310110064#
reversible: true
name: cholesterol precursor intracellular transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_36c0fee4_d2e5_4493_ad8a_4b0646a8d85e
initial concentration: NaN
type: Species
is: SBO:0000252
is: P27707
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:1633
name: DCK

metaM 3snpyr c
is: CHEBI:1665
initial concentration: 1.0
constant: false
has only substance units: false
name: 3-Sulfinopyruvate
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
is: HMDB02332

http://identifiers.org/biomodels.db/MODEL1310110064#_23c0db99_54eb_4d1c_bf16_6d90cb8bf2a9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8526
has only substance units: false
type: Species
is: A1L4Q0
name: DGKE
constant: false
initial amount: NaN

metaR r1969
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
product: MODEL1310110064#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110064#

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR PPCDC
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
reversible: false
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
name: phosphopantothenoylcysteine decarboxylase
product: MODEL1310110064#
is described by: ECO:0000269

metaM Rtotalcoa c
is: CHEBI:16189
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
initial amount: NaN
is: HMDB01448
name: R total Coenzyme A
boundary condition: false
has only substance units: false
constant: false

metaR DGCHOLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110064#
product: MODEL1310110064#
name: bile acid intracellular transport
type: Reaction

metaM nad r
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57540
name: NAD(1-)
has only substance units: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
boundary condition: false
is: HMDB00902
type: Species
initial concentration: 1.0

metaR r0720
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110064#
reversible: false
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reactant: MODEL1310110064#
is described by: ECO:0000000
fast: false

metaR INSTt2r
name: inositol transport in via proton symport
reactant: MODEL1310110064#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
type: Reaction
product: MODEL1310110064#

metaM HC01399 m
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: (S)-3-Hydroxytetradecanoyl-CoA
constant: false
is: CHEBI:27466
type: Species
boundary condition: false

metaM 10fthf7glu e
constant: false
is: HMDB00972
initial concentration: 1.0
is: CHEBI:57454
is: SBO:0000247
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](7)
type: Species
boundary condition: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial amount: NaN

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR 3SALATAi
reactant: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000304
kinetic law: MODEL1310110064#
name: 3-sulfino-alanine transaminase (irreversible)
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
reversible: false
fast: false
is: SBO:0000176
type: Reaction

metaR SO4OXAtex2
is: SBO:0000185
product: MODEL1310110064#
is described by: ECO:0000304
modifier: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
type: Reaction
name: sulfate transport via oxalate countertransport (2:1)

metaR RE3347C
reactant: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is described by: ECO:0000000
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
reversible: true
type: Reaction
name: RE3347

metaR r0801
type: Reaction
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:

metaR GLCt4
is: SBO:0000185
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
name: glucose transport via sodium symport
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true

metaR PSt3
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110064#
name: phosphatidylserine transport
product: MODEL1310110064#
is described by: ECO:0000269
kinetic law: MODEL1310110064#
reversible: true

metaR r1968
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
modifier: MODEL1310110064#
is: SBO:0000185
fast: false
type: Reaction

metaR NDPK4n
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reversible: true
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#

metaR r1600
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110064#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DURAD2
type: Reaction
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: dihydrothymin dehydrogenase (NADP)
kinetic law: MODEL1310110064#
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2
product: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

metaR CYSO
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
modifier: MODEL1310110064#
is described by: ECO:0000269
name: cysteine oxidase
reversible: false
fast: false
reactant: MODEL1310110064#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.20
product: MODEL1310110064#

metaR GUAt
reactant: MODEL1310110064#
name: Guanine transport
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reversible: true
fast: false
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

metaR ALCD21 L
is: SBO:0000176
modifier: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.99.24
name: alcohol dehydrogenase (L-1,2-propanediol)
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000304
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1

metaM ala L e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: SBO:0000247
is: HMDB00161
has only substance units: false
constant: false
is: CHEBI:16977
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
name: L-alanine

metaR r1827
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110064#

metaR CBR2
name: Carbonyl reductase [NADPH] 1
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
type: Reaction
modifier: MODEL1310110064#
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.189
is: SBO:0000176
product: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM duri e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16450
is: SBO:0000247
constant: false
name: Deoxyuridine
is: C00526
boundary condition: false
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
is: HMDB00012

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR r0472
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110064#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaM lys L m
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: L-lysinium(1+)
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
is: SBO:0000247
boundary condition: false

metaM hdca c
has only substance units: false
is: CHEBI:7896
is: HMDB00220
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: palmitate
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_275ae1d3_03e0_4d8d_a509_0f4d8c829b6e
type: Species
is: P48664
is encoded by: hsa:6511
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SLC1A6
constant: false

metaR 5MTHFt2le
type: Reaction
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false

metaR ARACHCPT2
fast: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110064#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: carnitine transferase
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_a0bbad26_e175_40a8_88e3_3b9306956c19
is: SBO:0000252
initial concentration: NaN
name: FDFT1
constant: false
initial amount: NaN
is encoded by: hsa:2222
has only substance units: false
type: Species
is: P37268
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_04746c65_fbde_47df_a61d_cec8f95b5850
constant: false
type: Species
boundary condition: true
is: P23921
is encoded by: hsa:6240
initial concentration: NaN
has only substance units: false
name: RRM1
is: SBO:0000252
initial amount: NaN

metaM sphings c
name: sphingosine(1+)
initial amount: NaN
boundary condition: false
is: HMDB00252
constant: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57756
type: Species

metaM mi14p c
is: CHEBI:58282
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
type: Species
is: HMDB00968
initial amount: NaN
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
boundary condition: false

metaR r1400
name: Active transport
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
reactant: MODEL1310110064#

metaR LGTHL
fast: false
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
name: lactoylglutathione lyase
modifier: MODEL1310110064#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.4.1.5

metaR r0921
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
fast: false
name: Postulated transport reaction
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: false
product: MODEL1310110064#

metaR r0722
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
is: SBO:0000176
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.3.12
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110064#

metaR PRODt2r
reversible: true
is described by: ECO:0000304
type: Reaction
is: SBO:0000185
modifier: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
name: D-proline reversible transport via proton symport

metaR FAOXC80
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
name: Beta oxidation of med/long chain fatty acid
is: SBO:0000176
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000269
modifier: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_f660db40_4784_447f_bcd9_19d8ff4b4ac0
name: OGDHL
initial amount: NaN
boundary condition: true
is encoded by: hsa:55753
is: SBO:0000252
has only substance units: false
is: Q9ULD0
constant: false
type: Species
initial concentration: NaN

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR r1602
reversible: true
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM cit e
initial concentration: 1.0
is: SBO:0000247
is: HMDB00094
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: citrate(3-)
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false

metaM Nacasp m
name: N-acetyl-L-aspartate(2-)
is: SBO:0000247
type: Species
is: HMDB00812
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

metaR GCC2am
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
name: glycine-cleavage complex (lipoamide), mitochondrial
is described by: ECO:0000269
product: MODEL1310110064#

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM duri c
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
type: Species
is: C00526
name: Deoxyuridine
is: CHEBI:16450
is: HMDB00012
boundary condition: false

metaR ASCBOX
product: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110064#
is described by: ECO:0000000
fast: false
name: ascorbic acid oxidase
type: Reaction
reactant: MODEL1310110064#

metaM ibcoa m
initial concentration: 1.0
is: CHEBI:57338
initial amount: NaN
is: HMDB01243
has only substance units: false
type: Species
name: isobutyryl-CoA(4-)
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_9e887a69_88be_49b1_a30c_f626abb31f49
name: _AI761708_1_m
boundary condition: true
is encoded by: hsa:AI761708
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r0470
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110064#
reversible: true
fast: false
product: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110064#

metaR r1299
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
name: Vesicular transport

http://identifiers.org/biomodels.db/MODEL1310110064#_0cb6bc86_899f_4468_bf17_72aea03fd4ea
type: Species
constant: false
is encoded by: hsa:5169
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ENPP3
initial amount: NaN
is: SBO:0000252
is: Q308M7

metaM hdca e
is: HMDB00220
initial amount: NaN
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
is: C00249
boundary condition: false
is: CHEBI:0

metaR DGNSKm
fast: false
reversible: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
is described by: ECO:0000269
name: deoxyguanosine kinase
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
product: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.113

metaR RE0453M
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
name: RE0453
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_bf24feef_db3f_4a7d_9f4b_aa6b5fd877d9
boundary condition: true
is encoded by: hsa:1119
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: CHKA
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_b06c86de_d45d_49e8_a710_e55e59d59037
initial amount: NaN
type: Species
is: SBO:0000297
has only substance units: false
initial concentration: NaN
name: NME1:NME2
constant: false
is encoded by: hsa:4830
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_a166f520_aa18_4b4f_b6f8_9e257a45e945
constant: false
boundary condition: true
initial concentration: NaN
name: NDUFS2
has only substance units: false
is encoded by: hsa:4720
initial amount: NaN
is: B7Z792
is: SBO:0000252
type: Species

metaR r0475
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaR r2526
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110064#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_f5eda45d_1bd2_470a_9989_a1bb6a13a510
initial amount: NaN
is encoded by: hsa:6512
initial concentration: NaN
constant: false
name: SLC1A7
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: O00341

metaR r0509
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:

metaR r1603
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
reversible: true
fast: false

metaR r0450
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
reversible: true
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
type: Reaction
modifier: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.3

metaR NTD1
fast: false
kinetic law: MODEL1310110064#
reversible: false
product: MODEL1310110064#
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
name: 5'-nucleotidase (dUMP)
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176

metaR GLUDym
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
product: MODEL1310110064#
is: SBO:0000176
kinetic law: MODEL1310110064#
reversible: true
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NADP), mitochondrial
type: Reaction

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaM stcoa m
initial amount: NaN
is: C00412
type: Species
boundary condition: false
has only substance units: false
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
initial concentration: 1.0
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: SBO:0000247
is: CHEBI:57394
constant: false

metaR RE0453N
fast: false
is: SBO:0000176
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
product: MODEL1310110064#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110064#

metaR PUNP7
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
kinetic law: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
fast: false
reactant: MODEL1310110064#
name: purine-nucleoside phosphorylase (Xanthosine)
modifier: MODEL1310110064#

metaR r1604
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110064#_8d580b5e_a85a_41f0_a511_873eb0d92d5a
type: Species
name: AACS
is encoded by: hsa:65985
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q86V21

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR r0653
product: MODEL1310110064#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
kinetic law: MODEL1310110064#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
fast: false
reactant: MODEL1310110064#

metaM cit c
type: Species
has only substance units: false
name: Citrate
constant: false
initial amount: NaN
is: C00158
boundary condition: false
is: HMDB00094
is: CHEBI:16947
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247

metaR r1554
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_6b541f6d_e001_4297_9b57_09c50d31d8a8
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9374
name: PPT2
initial amount: NaN
is: Q9UMR5
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaR r1318
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
name: Transport reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d6eb11c2_0086_433d_9b66_7e5b17be2ada
has only substance units: false
is: E9PH29
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:10935
initial concentration: NaN
name: PRDX3

metaR r2100
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_db0301d6_b1b3_414d_bdef_0c72bbb4d2a8
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110064#_1119a7a8_d362_4ad8_bef4_ba2dc347557a
is: Q59GJ6
is encoded by: hsa:4524
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: MTHFR

metaR DNDPt24m
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110064#
name: dTDP transport via dADP antiport
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_ea34fdd2_e530_43df_905b_6b8ccd9bfc6d
initial concentration: NaN
is: E9PB82
is encoded by: hsa:3295
constant: false
name: HSD17B4
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r0652
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176

metaM malthp e
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C01936
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: maltoheptaose

metaR r1963
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110064#
is described by: ECO:0000000

metaR DUTPDPn
reversible: false
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.23
reactant: MODEL1310110064#
fast: false
name: dUTP diphosphatase, nuclear
type: Reaction
modifier: MODEL1310110064#
is described by: ECO:0000269
kinetic law: MODEL1310110064#

metaR r1605
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185

metaR UMPK6n
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
reactant: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
reversible: true
name: UMP kinase (dCTP),nuclear
is described by: ECO:0000269
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110064#

metaM gpail hs c
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
is: CHEBI:17049

metaR r1557
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_4164ab0d_1e47_46c3_b518_ab69ecc0ba2e
has only substance units: false
is encoded by: hsa:978
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: CDA
initial amount: NaN
is: P32320
constant: false
type: Species

metaM h2o2 x
initial amount: NaN
is: HMDB03125
is: CHEBI:16240
is: C00027
type: Species
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
name: Hydrogen peroxide
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR PPAn
is described by: ECO:0000000
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110064#
name: inorganic diphosphatase, nuclear
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_65716f3b_4e4a_477e_b019_83d42214a5fe
is: Q8IXK2
initial amount: NaN
boundary condition: true
is encoded by: hsa:79695
type: Species
name: GALNT12
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r0879
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM acac c
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:13705
constant: false
initial concentration: 1.0
name: acetoacetate

metaR CPPPGO
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
reversible: false
name: coproporphyrinogen oxidase (O2 required)
is: SBO:0000176
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
is version of: http://identifiers.org/ec-code/1.3.3.3
is described by: ECO:0000304

metaM arachcoa c
initial amount: NaN
constant: false
has only substance units: false
is: HMDB04258
is: SBO:0000247
is: CHEBI:15527
boundary condition: false
name: arachidyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
type: Species

metaR r0390
fast: false
reversible: true
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110064#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_131697e2_79e1_4c36_87f3_5e7a18a11b6d
is encoded by: hsa:23305
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: B2RB13
type: Species
constant: false
name: ACSL6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b31169ec_6cd3_4873_9d24_90aa61ee2f59
is: Q6IBA0
name: NDUFS5
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:4725

metaR r2101
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110064#_ffacb22d_39f0_40f8_b9b1_f0b6b4fcd9a9
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: P49915
initial amount: NaN
is encoded by: hsa:8833
name: GMPS
is: SBO:0000252
constant: false

metaM ser D c
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
type: Species
constant: false
is: HMDB03406
has only substance units: false
name: D-serine
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM nh4 e
is: HMDB00051
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
is: CHEBI:28938
constant: false
name: ammonium
has only substance units: false
boundary condition: false

metaM e4p c
boundary condition: false
is: CHEBI:16897
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
type: Species
is: SBO:0000247
is: HMDB01321
constant: false
name: D-Erythrose 4-phosphate
has only substance units: false
is: C00279
initial concentration: 1.0
initial amount: NaN

metaR r0651
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
modifier: MODEL1310110064#
is: SBO:0000176
reversible: true
product: MODEL1310110064#

metaR LNLCCPT2
reversible: false
type: Reaction
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110064#

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_1351257c_ab33_40ad_8cf6_f50cf130d296
boundary condition: true
initial concentration: NaN
is: F8WDN9
is encoded by: hsa:27068
is: SBO:0000252
type: Species
initial amount: NaN
name: PPA2
constant: false
has only substance units: false

metaR r0474
fast: false
product: MODEL1310110064#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR ACACT1x
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000134
fast: false
reversible: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
modifier: MODEL1310110064#

metaR r1606
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM tststerone r
constant: false
is: SBO:0000247
is: HMDB00234
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: testosterone
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347

metaR r1556
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#

metaR HMGCOASim
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
name: Hydroxymethylglutaryl CoA synthase (ir)
type: Reaction
reversible: false
product: MODEL1310110064#
fast: false

metaM prostgh2 r
is: CHEBI:57405
is: HMDB01381
initial concentration: 1.0
boundary condition: false
name: prostaglandin H2(1-)
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

metaM his L m
is: SBO:0000247
has only substance units: false
is: HMDB00177
is: CHEBI:15971
constant: false
boundary condition: false
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
type: Species
initial amount: NaN

metaM HC00718 c
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: CHEBI:57781
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_d1c9aaf6_5d0d_454d_ac0c_a0c182e59083
is encoded by: hsa:57419
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: SLC24A3
has only substance units: false
is: Q9HC58
boundary condition: true

metaR PUNP4
is described by: ECO:0000269
modifier: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyguanosine)
reversible: true
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM no e
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
type: Species
initial amount: NaN
has only substance units: false
is: C00533
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16480
name: Nitric oxide

metaR CYTK1n
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP),nuclear
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110064#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110064#
reversible: true
is described by: ECO:0000212
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/6.2.1.5

metaR r1551
product: MODEL1310110064#
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110064#_4b961028_0182_43aa_ad4f_5ea3f9b88422
is: Q8TEQ8
type: Species
constant: false
is: SBO:0000252
name: PIGO
is encoded by: hsa:84720
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM acac e
name: acetoacetate
is: HMDB00060
initial amount: NaN
is: CHEBI:13705
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

http://identifiers.org/biomodels.db/MODEL1310110064#_029a1f51_cd43_42ab_9ede_9917a82f2cd4
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1339
initial amount: NaN
name: COX6A2
is: Q02221

metaR r2102
kinetic law: MODEL1310110064#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1607
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110064#

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_526440a8_87c6_4970_9937_fbfd348b45bc
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: Q96P26
initial concentration: NaN
has only substance units: false
is encoded by: hsa:93034
name: NT5C1B

metaR LNLCCPT1
reactant: MODEL1310110064#
type: Reaction
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
modifier: MODEL1310110064#
is described by: ECO:0000269
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_82c72604_60ff_416e_b798_452d642fbcfb
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q8IXW6
constant: false
is encoded by: hsa:1809
has only substance units: false
name: DPYSL3

metaR DM anth
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR NTD5
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
name: 5'-nucleotidase (dTMP)
modifier: MODEL1310110064#
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
kinetic law: MODEL1310110064#
is: SBO:0000176

metaM ser D e
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:16523
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN
is: HMDB03406
has only substance units: false
name: D-serine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_054f94af_0244_438b_8374_97c5405fcbff
initial concentration: NaN
name: NME3
is: SBO:0000252
is encoded by: hsa:4832
constant: false
boundary condition: true
type: Species
is: Q13232
initial amount: NaN
has only substance units: false

metaR PUNP3
name: purine-nucleoside phosphorylase (Guanosine)
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
modifier: MODEL1310110064#
product: MODEL1310110064#

metaM uacgam c
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00290
is: CHEBI:57705
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

metaM nh4 c
boundary condition: false
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
has only substance units: false
constant: false
is: C01342
name: Ammonium
initial concentration: 1.0
is: CHEBI:28938
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_966a9675_f632_4c5e_bc92_f39580dce8ce
is encoded by: hsa:8659
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ALDH4A1
boundary condition: true

metaR ALCD21 D
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000176
name: alcohol dehydrogenase (D-1,2-propanediol)
is version of: http://identifiers.org/ec-code/1.1.99.24
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reactant: MODEL1310110064#
reversible: false
is described by: ECO:0000304
product: MODEL1310110064#

metaM ala L m
is: CHEBI:16977
name: L-alanine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR It
product: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000269
name: Iodide uniport
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#

metaR r2103
fast: false
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110064#

metaR r0504
fast: false
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
product: MODEL1310110064#
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
is: SBO:0000176
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM 5aop c
type: Species
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
name: 5-Amino-4-oxopentanoate
is: C00430
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:17549

http://identifiers.org/biomodels.db/MODEL1310110064#_975350a6_c73c_47ec_b359_d53d55452e15
name: PI4KA
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5297
initial amount: NaN
initial concentration: NaN
is: B4DYG5
constant: false
boundary condition: true

metaR r1608
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#

metaR GLCAASE4ly
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: false
name: beta-glucuronidase, lysosomal
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110064#

metaR GLYCLTtp
kinetic law: MODEL1310110064#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110064#
name: glycolate transport into peroxisome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_c3a5492a_39fa_4d95_a50d_c81e0fa4c9d6
is: B4DKS0
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC16A1
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:6566

metaR C14STRr
fast: false
is described by: ECO:0000134
name: C-14 sterol reductase
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
type: Reaction
is: SBO:0000176
product: MODEL1310110064#
reversible: false

metaM no c
is: C00533
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
constant: false
is: SBO:0000247
initial amount: NaN
name: Nitric oxide
is: CHEBI:16480
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: HMDB03378

metaR PUNP6
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyinosine)
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
product: MODEL1310110064#

metaM 34hpp e
is: CHEBI:36242
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
type: Species

metaM sphings l
is: HMDB00252
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57756
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
name: sphingosine(1+)

metaM lnlc r
type: Species
is: CHEBI:30245
has only substance units: false
name: linoleate
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial concentration: 1.0
boundary condition: false
is: HMDB00673

metaM andrstrn r
boundary condition: false
has only substance units: false
is: CHEBI:16032
is: SBO:0000247
is: HMDB00031
constant: false
initial amount: NaN
initial concentration: 1.0
name: androsterone
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
type: Species

metaR r2104
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000185
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110064#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1553
fast: false
reversible: true
product: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM HC02180 c
constant: false
is: CHEBI:28728
has only substance units: false
name: thromboxane-b2
initial concentration: 1.0
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM icit m
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: C00311
is: HMDB00193
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
boundary condition: false
is: CHEBI:16087
initial concentration: 1.0
name: Isocitrate

metaR r0656
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000176

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_918732c4_6e65_4157_894f_a5b6b37629b1
initial concentration: NaN
is: P11586
type: Species
name: MTHFD1
initial amount: NaN
is encoded by: hsa:4522
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaR PUNP5
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110064#
name: purine-nucleoside phosphorylase (Inosine)

metaR DNDPt36m
type: Reaction
reactant: MODEL1310110064#
name: dGDP transport via dCDP antiport
fast: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
product: MODEL1310110064#

metaR FPGSm
is version of: http://identifiers.org/ec-code/6.3.2.17
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
fast: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
reversible: false
name: folylpolyglutamate synthetase, mitochondrial
product: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
type: Reaction

metaM glyc S e
is: CHEBI:33871
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: 0
is: HMDB06372
has only substance units: false
type: Species
name: (S)-Glycerate
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_5a6ea247_6b5f_4ad0_b43c_cf5d2033e4ab
is encoded by: hsa:2713
name: GK3P
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaR DUMPtn
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
product: MODEL1310110064#
name: dUMP nuclear transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true

metaR GCALDD
reversible: false
reactant: MODEL1310110064#
name: Glycolaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
product: MODEL1310110064#
fast: false

metaR CYTK1m
type: Reaction
reactant: MODEL1310110064#
fast: false
name: cytidylate kinase (CMP),mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
product: MODEL1310110064#
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110064#

metaR NTD3
kinetic law: MODEL1310110064#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (dCMP)
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_af4561d3_ea33_485e_a360_8f1ff61fcebb
initial concentration: NaN
name: MCCC1
is encoded by: hsa:56922
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q96RQ3
boundary condition: true

metaR r2105
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000

metaM lys L x
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
is: HMDB00182
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:32551
initial concentration: 1.0
name: L-lysinium(1+)
is: SBO:0000247
type: Species

metaM nad m
initial amount: NaN
is: CHEBI:57540
is: C00003
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
is: HMDB00902
constant: false
type: Species

metaR RE2998M
modifier: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110064#
type: Reaction
name: RE2998
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110064#

metaR r1552
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110064#
is: SBO:0000185

metaR r0456
type: Reaction
is described by: ECO:0000000
fast: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110064#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.32
modifier: MODEL1310110064#

metaM lpam m
is: SBO:0000247
has only substance units: false
is: CHEBI:17460
constant: false
is: HMDB00962
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial concentration: 1.0
type: Species
initial amount: NaN
name: lipoamide

metaR P450SCC1m
kinetic law: MODEL1310110064#
name: cholesterol monooxygenase
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
fast: false
reversible: true
reactant: MODEL1310110064#

metaR r0655
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110064#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#

metaR r0502
reversible: true
product: MODEL1310110064#
modifier: MODEL1310110064#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_05ec8a4e_845d_4c96_8967_a12c2e437271
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6580
constant: false
is: O15245
initial concentration: NaN
name: SLC22A1
is: SBO:0000252
initial amount: NaN

metaR DGK1
is version of: http://identifiers.org/ec-code/2.7.4.8
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
modifier: MODEL1310110064#
reactant: MODEL1310110064#
name: deoxyguanylate kinase (dGMP:ATP)

metaM Rtotal2 e
initial amount: NaN
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
constant: false
boundary condition: false
is: HMDB00283
has only substance units: false
is: CHEBI:16988
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM memgacpail hs r
constant: false
is: SBO:0000247
is: HMDB00054
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: CHEBI:57977
has only substance units: false

metaR DCK1n
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110064#
name: Deoxycytidine kinase, nuclear (ATP)
is: SBO:0000176
fast: false
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reactant: MODEL1310110064#
reversible: true

metaM xol27oh m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
has only substance units: false
is: CHEBI:17703
name: 26-hydroxycholesterol
is: HMDB02103
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaR FRDPtr
kinetic law: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110064#
reversible: true
fast: false
name: lipid, flip-flop intracellular transport
is: SBO:0000185

metaM xol7aone r
is: CHEBI:17899
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_c2ac12f6_590e_46f1_8a43_8aeba3dc6893
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: C9JT23
name: NDUFA11
initial amount: NaN
type: Species
is encoded by: hsa:126328
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_3d1f327b_ee9f_45bb_a1af_0edb3c242f1c
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC24A4
is encoded by: hsa:123041
type: Species
is: SBO:0000252
constant: false
has only substance units: false

metaM frdp x
constant: false
initial amount: NaN
name: farnesyl pyrophosphate(3-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
type: Species
is: CHEBI:175763

metaR GLCAASE8ly
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110064#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110064#
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_6889c38b_159a_46db_8bdd_5f8ee3132be9
constant: false
type: Species
name: GLRX
is encoded by: hsa:2745
initial concentration: NaN
is: P35754
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_eeb274c7_426f_4415_b9ee_0a75b9370b35
is encoded by: hsa:570
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: Q14032
initial amount: NaN
name: BAAT
is: SBO:0000252

metaM bildglcur e
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
type: Species
is: HMDB03325
boundary condition: false
initial amount: NaN
is: CHEBI:58471
constant: false
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaM 3hmp m
is: HMDB00023
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
initial amount: NaN
type: Species
has only substance units: false
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
is: CHEBI:11805
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_b59c3edb_c188_4d39_9a9b_0e089df5f16f
initial concentration: NaN
boundary condition: true
is: P36551
is: SBO:0000252
initial amount: NaN
constant: false
name: CPOX
type: Species
has only substance units: false
is encoded by: hsa:1371

metaR ECOAH12m
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reactant: MODEL1310110064#
modifier: MODEL1310110064#

metaM nrpphr c
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
name: Norepinephrine
boundary condition: false
is: HMDB00216
is: CHEBI:33569
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_0491e0d1_a0f2_4c08_97ef_888bf17d95ba
is: P00374
initial amount: NaN
name: DHFR
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1719
has only substance units: false
constant: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM HC00361 c
is: CHEBI:58335
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial amount: NaN
has only substance units: false
name: sedoheptulose 1,7-bisphosphate(4-)

metaR LYStm
is: SBO:0000185
is described by: ECO:0000269
name: Lysine mitochondrial transport via ornithine carrier
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_e3b46099_d605_40ef_b395_90fdaeca6b99
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR SGALSIDEtg
is: SBO:0000185
name: sgalside hs intracellular transport
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110064#
fast: false
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_604dadf0_8738_4ce5_a8fd_9c0b7ed7a4b1
name: ACOX3
is encoded by: hsa:8310
is: O15254
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_224498a2_365a_4ae1_a41d_82b2cc008476
has only substance units: false
is: O75874
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3417
boundary condition: true
name: IDH1
type: Species
is: SBO:0000252

metaM glx c
is: SBO:0000247
is: HMDB00119
boundary condition: false
has only substance units: false
name: glyoxylate
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048

http://identifiers.org/biomodels.db/MODEL1310110064#_bd29479e_9b79_4939_8372_692e8a84de12
constant: false
has only substance units: false
is: O95169
initial concentration: NaN
type: Species
is encoded by: hsa:4714
initial amount: NaN
boundary condition: true
name: NDUFB8
is: SBO:0000252

metaM Rtotal2 c
is: CHEBI:60377
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
boundary condition: false
constant: false
is: C00055
type: Species
initial concentration: 1.0
is: HMDB00095
name: R total 2 position

metaR r0434
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110064#
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
reactant: MODEL1310110064#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_2385c92b_ef7e_49b0_a3f9_25fbd074c6d6
is encoded by: hsa:1431
boundary condition: true
name: CS
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_93c50412_1e37_41c7_81b1_4dc3f19bbc27
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:93034
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: NT5C1B
is: Q96P26

http://identifiers.org/biomodels.db/MODEL1310110064#_7b34f9a9_0b28_4250_b90e_292288c7e9ef
is encoded by: hsa:1718
constant: false
initial amount: NaN
name: DHCR24
initial concentration: NaN
is: SBO:0000252
is: Q15392
boundary condition: true
type: Species
has only substance units: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM bildglcur c
is: CHEBI:58471
constant: false
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB03325
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_1851e09a_4ae2_4027_832e_2f0287ff28c2
constant: false
is encoded by: hsa:10050
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9Y2C5
initial concentration: NaN
name: SLC17A4

http://identifiers.org/biomodels.db/MODEL1310110064#_322454e1_890c_44b9_93f7_3e6d130ccef5
initial amount: NaN
name: TXNRD1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7296
boundary condition: true
is: Q16881
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_5b7b1fe1_bb4a_4c0c_bf4a_1eb7b12e388d
is: P51178
is encoded by: hsa:5333
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: PLCD1
constant: false
has only substance units: false

metaR r1744
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#

metaM HC02180 e
initial amount: NaN
name: thromboxane-b2
is: SBO:0000247
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
has only substance units: false
is: CHEBI:28728
initial concentration: 1.0
boundary condition: false
type: Species

metaR SUCCTD
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM met L e
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00696
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16643
type: Species
name: L-methionine

http://identifiers.org/biomodels.db/MODEL1310110064#_df8cc932_36a5_4f81_b397_1277b831fe09
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: _R06874_1_r
is encoded by: hsa:R06874
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_0a928cb6_4558_4ff1_a53e_c15c79f0dfdf
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10588
is: P49914
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: MTHFS
type: Species

metaR RE2349C
type: Reaction
name: RE2349
kinetic law: MODEL1310110064#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
modifier: MODEL1310110064#
product: MODEL1310110064#

metaM ile L e
boundary condition: false
is: CHEBI:17191
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: L-isoleucine
has only substance units: false

metaR r0670
kinetic law: MODEL1310110064#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reversible: false
reactant: MODEL1310110064#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

metaR PAPtg
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
name: adenosine 3',5'-bisphosphate Golgi transport
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110064#

metaR SERt4
reactant: MODEL1310110064#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110064#
product: MODEL1310110064#
fast: false
name: L-serine via sodium symport
reversible: false
kinetic law: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR

metaR INSTt4 2
type: Reaction
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
fast: false
name: inositol transport via sodium symport
reactant: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000006
reversible: true
product: MODEL1310110064#

metaR D3AIBTm
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reversible: true
kinetic law: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reactant: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110064#
fast: false

metaM xol7aone m
is: HMDB01993
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false
type: Species
is: CHEBI:17899

http://identifiers.org/biomodels.db/MODEL1310110064#_833d6f9f_11eb_449e_87bb_39760a76d1a7
name: COX6A1
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P12074
type: Species
is encoded by: hsa:1337
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ee6069ea_71e3_4080_b89a_9b2f1c7415c0
boundary condition: true
is: SBO:0000252
name: RRM1
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:6240
is: P23921
initial concentration: NaN
has only substance units: false

metaM C02528 c
is: HMDB00518
constant: false
is: CHEBI:36234
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

metaR NODe
product: MODEL1310110064#
name: NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
is described by: ECO:0000134

metaR r1743
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#

metaR r2311
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110064#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_caadfa50_3f5c_40ab_8800_96a1d8dafccb
is encoded by: hsa:79646
initial amount: NaN
boundary condition: true
name: PANK3
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: Q9H999
has only substance units: false

metaM retinal cis 13 r
initial amount: NaN
is: CHEBI:45487
is: HMDB06220
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: SBO:0000247
name: 13-cis-retinal
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_3583aab7_7920_4f9b_adb4_76a7b983dc63
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9380
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9UBQ7
name: GRHPR

metaR BHBt
reactant: MODEL1310110064#
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000185
product: MODEL1310110064#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_95f21dd0_8e91_4835_a51b_3641128de778
is: SBO:0000252
boundary condition: true
constant: false
name: VNN3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55350
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_96dec636_cdf5_4b62_8377_ce3975ccbe17
initial concentration: NaN
type: Species
is encoded by: hsa:1716
has only substance units: false
is: SBO:0000252
boundary condition: true
name: DGUOK
constant: false
is: E5KSL6
initial amount: NaN

metaM fad c
is: C00016
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
type: Species
is: HMDB01248
boundary condition: false
is: CHEBI:16238
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
initial concentration: 1.0
has only substance units: false

metaM pppg9 c
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
type: Species
has only substance units: false
is: HMDB01097
is: CHEBI:57307
boundary condition: false
initial amount: NaN
name: Protoporphyrinogen IX
is: C01079

http://identifiers.org/biomodels.db/MODEL1310110064#_cc834b20_e226_44a6_9280_b2f32d0d76c6
constant: false
type: Species
boundary condition: true
is encoded by: hsa:205
has only substance units: false
name: AK4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P27144

metaM prostge1 e
name: prostaglandin E1(1-)
constant: false
is: SBO:0000247
is: CHEBI:57397
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01442
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_4f6d992d_70ea_4a51_aec8_18853cb00b82
name: NDUFS3
is: O75489
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:4722
is: SBO:0000252
has only substance units: false

metaM met L c
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: CHEBI:16643
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00696
constant: false
initial amount: NaN

metaR GLNyLATthc
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM CE2417 m
boundary condition: false
is: CHEBI:28387
type: Species
is: HMDB11123
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR r0672
product: MODEL1310110064#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
modifier: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false

metaR DM datp n
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM datp(n)
type: Reaction

metaM thbpt c
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0
has only substance units: false
is: HMDB00027
initial amount: NaN
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
boundary condition: false
name: D-4'-Phosphopantothenate
is: SBO:0000247
type: Species
is: C03492
initial concentration: 1.0
constant: false
is: CHEBI:10986
is: HMDB01016
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_775e85a4_cbb4_48ad_943b_34d0aa0ab8cc
has only substance units: false
is encoded by: hsa:84532
initial concentration: NaN
constant: false
name: ACSS1
initial amount: NaN
boundary condition: true
type: Species
is: Q9NUB1
is: SBO:0000252

metaR RE1525M
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110064#
type: Reaction
reversible: true
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110064#
name: RE1525

http://identifiers.org/biomodels.db/MODEL1310110064#_7d6480a1_e23d_4058_8ff1_8d9301cc7344
type: Species
boundary condition: true
is encoded by: hsa:5831
initial concentration: NaN
has only substance units: false
is: A6NFM2
is: SBO:0000252
initial amount: NaN
constant: false
name: PYCR1

metaR r0033
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reversible: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110064#
fast: false
is: SBO:0000176
type: Reaction
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reactant: MODEL1310110064#

metaM arab L c
initial amount: NaN
is: CHEBI:30849
boundary condition: false
constant: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
has only substance units: false
name: L-arabinose
is: SBO:0000247
is: HMDB00646

metaR r2310
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction

metaR RE3556C
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
name: RE3556
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
is: SBO:0000176
reversible: true

metaM ile L c
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
initial amount: NaN
is: CHEBI:17191

metaM C02528 e
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: CHEBI:36234
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: HMDB00518
constant: false
name: chenodeoxycholate

http://identifiers.org/biomodels.db/MODEL1310110064#_d5d18b57_d777_4602_a482_8992f6e8e6c9
is encoded by: hsa:5281
has only substance units: false
name: PIGF
is: Q6IB04
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM dcmp n
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial amount: NaN
is: HMDB01202
constant: false
initial concentration: 1.0
name: dCMP(2-)
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57566

metaM prostge1 c
constant: false
is: HMDB01442
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial amount: NaN
is: CHEBI:57397
initial concentration: 1.0
name: prostaglandin E1(1-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_5413f0ce_9c85_49e9_a2ba_e8448fd5292a
is encoded by: hsa:23007
is: Q4KWH8
constant: false
is: SBO:0000252
name: PLCH1
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_81240092_2670_490b_83b2_ebfc4b6e325a
is encoded by: hsa:29926
name: GMPPA
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_4bf1a6af_18a5_4ee2_a940_bba889526813
name: NDUFB9
initial amount: NaN
constant: false
is encoded by: hsa:4715
initial concentration: NaN
is: Q9Y6M9
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

metaR RE0830N
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: true
name: RE0830

metaM Sfglutth c
name: S-formylglutathionate(1-)
is: SBO:0000247
is: HMDB01550
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: CHEBI:57688
constant: false
has only substance units: false

metaR ASNNm
reversible: false
name: L-asparaginase (mitochondrial)
reactant: MODEL1310110064#
product: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
fast: false
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.5.1.1

http://identifiers.org/biomodels.db/MODEL1310110064#_dada4bd1_473a_4eca_890d_573bba254ca7
initial concentration: NaN
is encoded by: hsa:1607
has only substance units: false
is: SBO:0000252
name: DGKB
boundary condition: true
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_4c09a933_f426_45c1_b9e0_6b94acdad6ab
is: O94777
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8818
initial concentration: NaN
type: Species
name: DPM2
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_9634f4d2_1d34_40cb_9d11_f59a9069e17a
constant: false
boundary condition: true
type: Species
is encoded by: hsa:642502
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _642502_1_c

http://identifiers.org/biomodels.db/MODEL1310110064#_5d25fd16_c440_4174_852c_59d6a260e4bf
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is: F8W1L5
type: Species
initial concentration: NaN
name: GPD1
is encoded by: hsa:2819

metaM acmana e
is: SBO:0000247
has only substance units: false
boundary condition: false
name: N-acetyl-D-mannosamine
constant: false
initial amount: NaN
is: CHEBI:17122
type: Species
initial concentration: 1.0
is: HMDB01129
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645

metaR XANtx
name: xanthine diffusion in peroxisome
fast: false
product: MODEL1310110064#
reversible: false
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110064#_91d838e4_d0ff_483a_9c7d_3639864107ff
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:197257
constant: false
boundary condition: true
initial concentration: NaN
name: LDHD

metaM frdp r
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00448
has only substance units: false
type: Species
is: HMDB00961
is: CHEBI:175763
name: Farnesyl diphosphate
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0

metaR C204CRNt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction
name: arachidonic acid transport into the mitochondria
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110064#_a7091e00_35f8_477e_a6b7_0a455b7b9788
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:D29675
name: _D29675_1_c
has only substance units: false
initial amount: NaN

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR 5ADTSTSTERONEte
product: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000000
name: 5 alpha dihydrotesterone transport
is: SBO:0000185
type: Reaction

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_ce3edd95_3a51_47ea_8ecc_e66c3103b1b7
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q16647
is encoded by: hsa:5740
type: Species
initial amount: NaN
name: PTGIS
has only substance units: false

metaR RETH2e
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: retinyl ester hydrolase (11-cis), extracellular
fast: false
reversible: false
reactant: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110064#_8f84e008_940c_49fb_8133_ed7a01235545
constant: false
name: PIGU
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9H490
is encoded by: hsa:128869

metaM pail4p hs c
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58178
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN

metaR r1559
kinetic law: MODEL1310110064#
is: SBO:0000185
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000

metaR r0437
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.1.2.13
type: Reaction
product: MODEL1310110064#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110064#_65a84271_668e_4dca_bfad_c200bf17b917
is: Q02218
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4967
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: OGDH
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_6010e0f4_ac74_4e20_bd27_6c729c410432
is: P00414
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4514
initial concentration: NaN
type: Species
boundary condition: true
name: COX3
initial amount: NaN

metaR GLNATB0tc
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Glutamine into the intestinal cells by ATB0 transporter
type: Reaction

metaM arab L e
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
is: SBO:0000247
has only substance units: false
is: HMDB00646
name: L-arabinose
initial amount: NaN
is: CHEBI:30849

metaM acac m
initial concentration: 1.0
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
is: HMDB00060
type: Species
is: CHEBI:13705
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN

metaR PPBNGS
reactant: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.24
is: SBO:0000176
reversible: false
modifier: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
name: porphobilinogen synthase
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_1a47035b_9a00_423d_aa0e_7cfdac6cbca3
is: Q549M5
is: SBO:0000252
is encoded by: hsa:4718
type: Species
has only substance units: false
boundary condition: true
name: NDUFC2
initial concentration: NaN
constant: false
initial amount: NaN

metaR ADRNCOAtx
reactant: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
name: fatty acid intracellular transport
type: Reaction
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is described by: ECO:0000000

metaR TSTSTERONEtr
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110064#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000185
name: testosterone intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110064#_75a85bc7_d7cc_4ef7_95b2_3361e81fcbb5
type: Species
name: TXNRD1
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7296
constant: false
initial concentration: NaN

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_cbb818f6_ec2d_4ae0_9170_984859271ebf
boundary condition: true
is: Q14117
is encoded by: hsa:1807
is: SBO:0000252
type: Species
name: DPYS
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR DHFR
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
reversible: true
is described by: ECO:0000254
is: SBO:0000176
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
name: dihydrofolate reductase
kinetic law: MODEL1310110064#

metaR r0936
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110064#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000185
name: Transport reaction
type: Reaction
product: MODEL1310110064#

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR r2315
is described by: ECO:0000000
reactant: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#
reversible: true
type: Reaction
product: MODEL1310110064#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_2e606aa2_32ea_42b0_8a7f_dc10c2e03ac2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:W74642
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: _W74642_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_cd257afa_ac6d_4f88_a61c_512c21f66a33
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC3A2:SLC7A6
has part: Q92536
constant: false
has only substance units: false
type: Species
is encoded by: hsa:9057
is: SBO:0000297

metaR BAMPPALDOX
modifier: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
fast: false
is described by: ECO:0000212

metaR RE1901R
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
kinetic law: MODEL1310110064#
name: RE1901
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_d38d0e0f_e3f2_446d_8213_a2639001d1b8
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:7359
name: _7359_1_c

metaM prostgh2 c
constant: false
is: CHEBI:57405
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
name: prostaglandin H2(1-)
is: HMDB01381
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM ala L c
is: HMDB00161
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: L-alanine
is: CHEBI:16977
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
constant: false

metaM tststerone c
is: HMDB00234
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial concentration: 1.0
is: SBO:0000247
name: testosterone
has only substance units: false
is: CHEBI:17347
type: Species

metaR ARACHDtr
is described by: ECO:0000000
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110064#
fast: false
type: Reaction
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000185
reactant: MODEL1310110064#

metaM thp2c x
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB12130
name: 1-piperideine-6-carboxylate
constant: false
is: CHEBI:16987
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_5b49951b_5d68_43c8_9cc6_f4a152b1cd9a
initial concentration: NaN
name: NDUFA1
type: Species
boundary condition: true
is: Q6IBB5
is encoded by: hsa:4694
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM ser L e
is: SBO:0000247
boundary condition: false
constant: false
name: L-serine
initial concentration: 1.0
is: CHEBI:17115
type: Species
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
initial amount: NaN

metaR r2314
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110064#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110064#

metaR ACNAMtn
kinetic law: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
reactant: MODEL1310110064#
name: N-acetylneuraminate nuclear import
is: SBO:0000185
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r0937
kinetic law: MODEL1310110064#
name: Transport reaction
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110064#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_ea2febf5_20f3_4085_838a_b3dc1365abd6
is: SBO:0000252
initial amount: NaN
name: SDHC
has only substance units: false
is: Q99643
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6391
constant: false
type: Species

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR TSTSTERONEt
kinetic law: MODEL1310110064#
fast: false
type: Reaction
name: Testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
product: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_2d7c3e08_a0c8_4684_9ade_075baa63a338
initial concentration: NaN
type: Species
is encoded by: hsa:412
initial amount: NaN
is: SBO:0000252
name: STS
boundary condition: true
has only substance units: false
constant: false
is: P08842

http://identifiers.org/biomodels.db/MODEL1310110064#_f68b70f3_d31d_4e8d_a6d1_68e536a39460
type: Species
name: ADH1A:ADH1B
is: SBO:0000297
initial amount: NaN
boundary condition: true
has part: P07327
constant: false
initial concentration: NaN
is encoded by: hsa:124
has only substance units: false

metaM ump r
boundary condition: false
is: CHEBI:57865
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
is: HMDB00288
name: UMP
initial amount: NaN

metaM nad x
constant: false
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
is: C00003
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
type: Species
is: HMDB00902
is: CHEBI:57540
boundary condition: false

metaM glyc3p c
is: C00093
boundary condition: false
initial amount: NaN
is: HMDB00126
constant: false
is: CHEBI:57597
initial concentration: 1.0
name: Glycerol 3-phosphate
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: SBO:0000247
type: Species

metaR LEUTA
type: Reaction
reactant: MODEL1310110064#
name: leucine transaminase
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110064#

metaR 5MTHFt
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
reversible: true
fast: false
is described by: ECO:0000269
product: MODEL1310110064#
modifier: MODEL1310110064#
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#

metaM o2 c
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
is: CHEBI:15379
is: C00007
is: HMDB01377
name: O2
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r2313
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true

metaR ADNt
name: adenosine facilated transport in cytosol
kinetic law: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

metaR ORNt4m
fast: false
name: ornithine mitochondrial transport exchange with citruline
type: Reaction
modifier: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
kinetic law: MODEL1310110064#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185

metaR FAOXC18480m
is: SBO:0000176
name: Beta oxidation of fatty acid
modifier: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM HC02210 c
has only substance units: false
is: SBO:0000247
boundary condition: false
name: prostaglandin-d3
initial amount: NaN
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
type: Species
is: CHEBI:34939
initial concentration: 1.0

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM tststerone e
is: HMDB00234
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial concentration: 1.0
is: CHEBI:17347
name: testosterone
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_60baea26_2474_4cb0_a49a_735e6148851c
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:767
name: CA8
is: SBO:0000252
boundary condition: true
is: P35219

metaR FE3MTP1
is: SBO:0000185
modifier: MODEL1310110064#
reversible: false
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
type: Reaction
name: transport of ferrous iron into blood
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#

metaM icit c
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
is: HMDB00193
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16087
has only substance units: false
type: Species
is: C00311
name: Isocitrate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_ef3aa7bb_8515_4caa_948b_f502d473314f
is: SBO:0000252
name: PPT1
boundary condition: true
has only substance units: false
constant: false
is: Q6FGQ4
initial amount: NaN
type: Species
is encoded by: hsa:5538
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_2972eb37_cb4a_4860_a102_760b6ca2a031
has only substance units: false
is: P57054
boundary condition: true
name: PIGP
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:51227

metaM C02528 r
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: chenodeoxycholate
constant: false
is: CHEBI:36234
is: HMDB00518
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

metaM HC01609 e
name: UroporphyrinogenI
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:28766
is: SBO:0000247
boundary condition: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766

metaR r2312
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000185

metaM ha pre1 e
initial concentration: 1.0
type: Species
constant: false
name: hyaluronan biosynthesis, precursor 1
initial amount: NaN
is: CHEBI:16126
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_bc383a24_765e_4b90_9c8d_f5bcb25f9fea
type: Species
constant: false
is encoded by: hsa:55902
is: Q5QPH3
name: ACSS2
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_50f37edf_ec48_40b3_b143_9d9bf6e5b3dc
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P39877
type: Species
name: PLA2G5
is encoded by: hsa:5322
initial amount: NaN
initial concentration: NaN
constant: false

metaM g3p c
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: HMDB01112
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3930
is: C00661
is: CHEBI:58027
boundary condition: false
is: SBO:0000247
name: Glyceraldehyde 3-phosphate
constant: false
type: Species
has only substance units: false

metaM dhap e
name: glycerone phosphate(2-)
is: SBO:0000247
type: Species
is: HMDB01473
initial concentration: 1.0
constant: false
is: CHEBI:57642
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial amount: NaN
boundary condition: false
has only substance units: false

metaR ILEt5m
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
product: MODEL1310110064#
is: SBO:0000185
name: Isoleucine mitochondrial transport
reactant: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_21041047_6a43_4b37_8fe0_670455e9cd78
name: NDUFB5
is: O43674
type: Species
is: SBO:0000252
is encoded by: hsa:4711
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_be756df2_b267_4aaa_8e31_ab702a9dab36
type: Species
constant: false
boundary condition: true
has only substance units: false
is: Q15274
name: QPRT
is encoded by: hsa:23475
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_353702a9_4e73_4c00_9a8a_a7a0f6eecaef
initial concentration: NaN
has only substance units: false
name: PAPSS2
initial amount: NaN
is encoded by: hsa:9060
is: SBO:0000252
is: O95340
constant: false
type: Species
boundary condition: true

metaR r2319
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110064#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000185
kinetic law: MODEL1310110064#

metaR BILIRUBtr
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
name: lipid, flip-flop intracellular transport
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaM idp e
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03335
is: SBO:0000247
type: Species
name: IDP(3-)
boundary condition: false

metaM bilirub c
is: SBO:0000247
boundary condition: false
name: bilirubin(2-)
is: CHEBI:57977
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: HMDB00054
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f354bc51_ffeb_45fd_a531_89ac03c127be
constant: false
is: O60427
initial amount: NaN
is encoded by: hsa:3992
name: FADS1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaR NADH2 u10m
is version of: http://identifiers.org/ec-code/1.6.99.3
fast: false
modifier: MODEL1310110064#
is described by: ECO:0000134
reversible: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.6.5.3
reactant: MODEL1310110064#
type: Reaction
name: NADH dehydrogenase, mitochondrial
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
product: MODEL1310110064#

metaM o2 e
has only substance units: false
is: C00007
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
name: O2
initial amount: NaN
constant: false
is: HMDB01377
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR GCHOLAte
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
name: bile acid intracellular transport
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000

metaM glcur l
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
is: SBO:0000247
constant: false
type: Species
is: HMDB00127
is: CHEBI:15748
initial amount: NaN
has only substance units: false

metaR r0186
type: Reaction
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is: SBO:0000176
product: MODEL1310110064#
reversible: false
fast: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_d30fabe0_2c8a_4b82_a845_e3dc79c1e828
type: Species
is: SBO:0000252
is: P78330
initial concentration: NaN
initial amount: NaN
constant: false
name: PSPH
has only substance units: false
is encoded by: hsa:5723
boundary condition: true

metaR DM mem2emgacpail prot hs r
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM mem2emgacpail prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_25d312b2_c7d8_4462_a7b3_d68883a81a5f
type: Species
is: P19404
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:4729
initial amount: NaN
name: NDUFV2
initial concentration: NaN
constant: false

metaR DNDPt16m
is described by: ECO:0000269
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUDP transport via dADP antiport
reversible: false
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_8efc65e4_58d1_4fe3_84f6_2709b3f49dd2
name: DHFR
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1719
initial concentration: NaN
is: P00374

metaR RIBt
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110064#
name: ribose transport via diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_c380e6a8_fc7a_489c_8f37_503bd2a9f3cd
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: CEPT1
is: B3KN25
is encoded by: hsa:10390
type: Species
is: SBO:0000252
constant: false

metaM dcmp c
has only substance units: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
is: HMDB01202
type: Species
boundary condition: false
constant: false
name: dCMP
is: SBO:0000247
initial amount: NaN
is: CHEBI:57566
is: C00239

http://identifiers.org/biomodels.db/MODEL1310110064#_a9e24e8c_42cb_48ad_b401_78903390e4a0
constant: false
is encoded by: hsa:6888
boundary condition: true
has only substance units: false
name: TALDO1
is: P37837
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ce0b11ee_4899_490c_9745_b15839306f60
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:79966
has only substance units: false
type: Species
name: SCD5
is: Q86SK9
initial concentration: NaN

metaR CSPG Atly
product: MODEL1310110064#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
name: chondroitin sulfate A transport, extracellular to lysosome
reactant: MODEL1310110064#

metaR SERDGLNexR
name: D-Serine/Glutamine reversible exchange
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
type: Reaction
fast: false
product: MODEL1310110064#
is: SBO:0000185
modifier: MODEL1310110064#

metaR RE0453C
is: SBO:0000176
kinetic law: MODEL1310110064#
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
type: Reaction
name: RE0453

metaM xol27oh r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02103
constant: false
name: 26-hydroxycholesterol
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species
is: SBO:0000247
is: CHEBI:17703

metaR RE1254C
name: RE1254
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#

metaM acac x
type: Species
is: SBO:0000247
constant: false
is: HMDB00060
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
name: acetoacetate
has only substance units: false
initial concentration: 1.0
is: CHEBI:13705

http://identifiers.org/biomodels.db/MODEL1310110064#_f641a67d_0f18_484d_84a5_7422b6a64f1b
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: ALDH1A3
has only substance units: false
is encoded by: hsa:220
initial amount: NaN
is: P47895
type: Species

metaR RE1519M
product: MODEL1310110064#
type: Reaction
fast: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
name: RE1519
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR DLNLCGt
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
name: fatty acid transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM tmndnccoa m
initial amount: NaN
has only substance units: false
name: timnodonyl coenzyme A
constant: false
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: HMDB06514
boundary condition: false

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is: HMDB01097
is: SBO:0000247
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
has only substance units: false
is: CHEBI:57307
is: C01079
name: Protoporphyrinogen IX
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR r2318
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110064#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110064#_448a2487_fb2f_416a_8826_d87cde5c3526
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC35A2
is: P78381
constant: false
is encoded by: hsa:7355

http://identifiers.org/biomodels.db/MODEL1310110064#_5666c6a6_d7f0_4620_9810_3d52b39811ce
is encoded by: hsa:3074
has only substance units: false
is: SBO:0000297
constant: false
has part: P07686
has part: P06865
type: Species
is encoded by: hsa:3073
name: HEXA:HEXB
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM gudac c
is: CHEBI:16344
boundary condition: false
name: guanidinoacetic acid
initial amount: NaN
notes: FORMULA: C3H7N3O2 CHARGE: 0 INCHI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00439 EHMN_ABBREVIATION: C00581
is: HMDB00128
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false

metaM fad m
name: Flavin adenine dinucleotide oxidized
type: Species
initial amount: NaN
is: CHEBI:16238
is: SBO:0000247
constant: false
is: C00016
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
is: HMDB01248

metaR RPE
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/5.1.3.1
fast: false
name: ribulose 5-phosphate 3-epimerase

http://identifiers.org/biomodels.db/MODEL1310110064#_41e7e86f_a722_4add_84bd_f61e9655d24d
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AF116616
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _AF116616_1_m

metaM dhap c
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01473
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
constant: false
has only substance units: false
name: Dihydroxyacetone phosphate
boundary condition: false
initial amount: NaN
is: C00111

http://identifiers.org/biomodels.db/MODEL1310110064#_0247ce49_2bee_4c6c_a0f1_fb8c2df581a3
initial concentration: NaN
is: P00439
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:5053
boundary condition: true
name: PAH

http://identifiers.org/biomodels.db/MODEL1310110064#_32a225a4_8a33_4da1_a9ad_be0b828fadc1
boundary condition: true
is encoded by: hsa:4830
has only substance units: false
is encoded by: hsa:4831
is: SBO:0000297
name: NME1:NME2
initial amount: NaN
has part: P15531
type: Species
initial concentration: NaN
has part: P22392
constant: false

metaR ACNAM9PL2
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.56
reactant: MODEL1310110064#
reversible: false
modifier: MODEL1310110064#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110064#
is described by: ECO:0000000
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD

metaM idp c
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
is: CHEBI:58280
constant: false
initial amount: NaN
is: HMDB03335
is: SBO:0000247
type: Species
name: IDP(3-)
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_1fa0c52c_7a59_40ea_afec_081eb95e2fe6
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: Q8N9L9
is: SBO:0000252
is encoded by: hsa:122970
has only substance units: false
name: ACOT4
boundary condition: true

metaM 4nph e
name: 4-nitrophenolate
type: Species
is: HMDB01232
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
boundary condition: false
is: CHEBI:57917

metaM trdrd m
name: Reduced thioredoxin
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial amount: NaN
boundary condition: false
is: CHEBI:15967
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_b49704ec_4b37_4e99_abe3_06daad68612f
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2710
initial concentration: NaN
constant: false
boundary condition: true
name: GK
type: Species
is: P32189
initial amount: NaN

metaR r2317
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110064#

metaM bilirub e
name: bilirubin(2-)
is: HMDB00054
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
type: Species
initial concentration: 1.0
boundary condition: false

metaR IDOURte
name: L-iduronate transport, extracellular
is described by: ECO:0000134
type: Reaction
product: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaR TKT2
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.2.1.1
modifier: MODEL1310110064#
reversible: true
product: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
name: transketolase

http://identifiers.org/biomodels.db/MODEL1310110064#_29a2461d_27d3_4e58_ab82_a2a0ba068348
initial amount: NaN
name: ALPPL2
is encoded by: hsa:251
is: P10696
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaM ser L c
name: L-serine
initial amount: NaN
constant: false
is: CHEBI:17115
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_4b9c527f_8bcb_4239_a2d3_bb9f0c119c4a
boundary condition: true
constant: false
name: BLVRB
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: P30043
is encoded by: hsa:645
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_104151ee_30a3_4c4d_933e_3499df7379d8
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:93183
initial amount: NaN
is: Q9H3S5
constant: false
type: Species
name: PIGM
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_55e91fc2_0e43_4428_af6f_c85eae50ee21
is: SBO:0000252
boundary condition: true
name: PLA2G10
initial amount: NaN
has only substance units: false
is encoded by: hsa:8399
constant: false
type: Species
initial concentration: NaN
is: O15496

metaM xan c
name: Xanthine
is: HMDB00292
is: CHEBI:17712
initial amount: NaN
type: Species
has only substance units: false
constant: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: C00385
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_0c3e89d9_0bb7_4979_818e_021d018890ed
constant: false
name: PRDX2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:7001
has only substance units: false

metaM prostgh2 e
has only substance units: false
is: HMDB01381
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)
boundary condition: false
initial amount: NaN
is: CHEBI:57405
type: Species
is: SBO:0000247
constant: false

metaR FOLR2
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
is: SBO:0000176
modifier: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
name: folate reductase
is described by: ECO:0000254
product: MODEL1310110064#

metaR UMPK
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110064#
reactant: MODEL1310110064#
name: UMP kinase

http://identifiers.org/biomodels.db/MODEL1310110064#_5b4669d8_f640_4a23_9b8c_108d273e4b8e
initial amount: NaN
is: SBO:0000252
name: CMPK1
initial concentration: NaN
type: Species
is: B2R6S5
boundary condition: true
is encoded by: hsa:51727
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_a85fd11c_c723_4c05_a4db_92004bf72b90
is encoded by: hsa:9488
constant: false
is: Q92521
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: PIGB

metaR r2316
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110064#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110064#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_7b1d63fc_1236_4a8b_a63b_7b295f6fd455
initial concentration: NaN
initial amount: NaN
name: PKM2
is: P14618
boundary condition: true
is encoded by: hsa:5315
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaR RE2814R
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
reversible: true
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110064#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_b71f2570_20a7_4079_a52d_e3d1e4dc4419
name: CLYBL
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:171425
initial concentration: NaN
constant: false

metaR TKT1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
name: transketolase
kinetic law: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
reversible: true
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2

metaM HC01377 m
type: Species
name: S-(3-Methylbutanoyl)-dihydrolipoamide
is: CHEBI:27462
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_a8c64204_eeaf_4242_bbd1_1c7c5b82da70
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2936
type: Species
name: GSR
is: P00390

http://identifiers.org/biomodels.db/MODEL1310110064#_9ec8c3cc_73dd_41c9_95bc_54831b122011
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: LDHB
is encoded by: hsa:3945
has only substance units: false
is: P07195
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_db661768_2bd5_4e98_b73a_dd9eb0068d46
has only substance units: false
initial amount: NaN
is encoded by: hsa:63917
constant: false
name: GALNT11
is: SBO:0000252
boundary condition: true
type: Species
is: B3KWF4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_bcb0a9b6_a55a_4443_858a_0369f9d05638
boundary condition: true
type: Species
is encoded by: hsa:10400
initial amount: NaN
name: PEMT
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM datp n
type: Species
name: dATP
is: HMDB01532
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00131

metaR THYOXt2
reactant: MODEL1310110064#
modifier: MODEL1310110064#
name: T4 transport via facilitated diffusion
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false
reversible: true
type: Reaction

metaR MTHFR3
is described by: ECO:0000134
type: Reaction
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.20
is: SBO:0000176
reversible: false
modifier: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
kinetic law: MODEL1310110064#
fast: false

metaM pail4p hs n
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
has only substance units: false
is: CHEBI:58178
is: SBO:0000247
initial amount: NaN

metaR CITtbm
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
type: Reaction
is: SBO:0000185
modifier: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
name: citrate transport, mitochondrial
product: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000269

metaR RE0830C
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110064#
product: MODEL1310110064#
name: RE0830

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: HMDB11123
type: Species
is: CHEBI:28387
boundary condition: false
initial concentration: 1.0

metaR r1561
type: Reaction
kinetic law: MODEL1310110064#
reversible: true
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_c42173e7_785d_4066_8bf4_79493ca71f06
type: Species
name: HADHB
is: SBO:0000252
is: P55084
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:3032

metaM prpp c
is: SBO:0000247
is: CHEBI:58017
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: C00119
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_3922cc94_be64_42a7_9ed1_a4436da0df77
is encoded by: hsa:4512
name: COX1
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q7GXY8
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_ecdd7210_0909_46a8_b9da_509a405d68b5
has only substance units: false
is: F5H2Y9
is: SBO:0000252
is encoded by: hsa:8854
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: ALDH1A2
initial concentration: NaN

metaM trdrd c
is: C00342
has only substance units: false
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM ump g
has only substance units: false
is: HMDB00288
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
constant: false
name: UMP(2-)

metaR OCDCEAtr
reactant: MODEL1310110064#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
fast: false
reversible: true
product: MODEL1310110064#

metaM datp m
initial concentration: 1.0
is: CHEBI:61404
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
name: dATP
boundary condition: false
initial amount: NaN
constant: false
is: C00131
is: HMDB01532
type: Species

metaR ARGtm
reactant: MODEL1310110064#
name: arginine mitochondrial transport via ornithine carrier
fast: false
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
kinetic law: MODEL1310110064#
reversible: true
is described by: ECO:0000269

metaR GACPAILter
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is: SBO:0000185
fast: false
product: MODEL1310110064#
name: glucosaminyl-acylphosphatidylinositol ER flippase
type: Reaction

metaR LINKDEG2ly
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: degradation of proteoglycan linkage region, lysosomal
fast: false
type: Reaction
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaR GTHP
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
kinetic law: MODEL1310110064#
name: glutathione peroxidase
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000134
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.11.1.9
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110064#

metaR r1560
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true

metaR RE3520E
reversible: true
type: Reaction
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000000
modifier: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110064#
fast: false
name: RE3520

http://identifiers.org/biomodels.db/MODEL1310110064#_e7ffd2f7_717c_45e9_bfaf_557acb61687a
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: _AA081045_1_c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA081045

http://identifiers.org/biomodels.db/MODEL1310110064#_17e02f48_aeae_483e_96ce_3551463dee56
is: Q6FG42
is: SBO:0000252
boundary condition: true
constant: false
name: NDUFA7
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:4701

metaR r2308
kinetic law: MODEL1310110064#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
type: Reaction
product: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true

metaR r0881
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
reversible: false
name: Active transport
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#

metaM Tn antigen g
type: Species
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C04383

metaR ACALDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
name: acetaldehyde reversible transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000000

metaR GTHS
notes: GENE_ASSOCIATION: (2937.1) SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110064#
is described by: ECO:0000269
name: glutathione synthetase
reversible: false
fast: false
modifier: MODEL1310110064#
is version of: http://identifiers.org/ec-code/6.3.2.3
reactant: MODEL1310110064#
is: SBO:0000176
type: Reaction
product: MODEL1310110064#

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaM cs e deg3 l
is: SBO:0000247
is: HMDB00127
is: CHEBI:15748
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H53NO44S4 CHARGE: -6
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_041ed415_05bd_44d5_bbfb_a5fe03660a9d
constant: false
initial amount: NaN
is encoded by: hsa:2739
name: GLO1
boundary condition: true
is: Q04760
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR PI45P5Pn
type: Reaction
kinetic law: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
reversible: false

metaR R group phosphotase 1
is: SBO:0000176
kinetic law: MODEL1310110064#
name: R group phosphotase 1
reactant: MODEL1310110064#
product: MODEL1310110064#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false

metaR RE1532M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110064#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
name: RE1532

http://identifiers.org/biomodels.db/MODEL1310110064#_76100ca8_f366_4119_9826_e9e9a0d1aa99
is: Q86WU2
name: LDHD
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:197257
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_ee59e710_b4c4_4974_8929_4aa8ff2a98a7
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q02252
name: ALDH6A1
initial concentration: NaN
type: Species
is encoded by: hsa:4329
boundary condition: true

metaR r0512
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
kinetic law: MODEL1310110064#
fast: false
is: SBO:0000176
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
reversible: true

metaM pd3 c
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB06500
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
boundary condition: false
name: Previtamin D3
initial concentration: 1.0
has only substance units: false

metaM 7thf e
constant: false
name: heptaglutamyl folate (THF)
initial concentration: 1.0
has only substance units: false
is: HMDB06559
notes: FORMULA: C49H57N13O24 CHARGE: -8
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110064#_423910b3_c61d_4999_b8bd_3bb75edafe7b
initial amount: NaN
has only substance units: false
name: COX7B
is: P24311
constant: false
is: SBO:0000252
is encoded by: hsa:1349
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_886f7114_1aec_4e45_ba70_ef815ffe38ae
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: SUOX
is: P51687
initial amount: NaN
is encoded by: hsa:6821

metaM acmana r
name: N-acetyl-D-mannosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false
is: HMDB01129
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:17122
is: SBO:0000247
type: Species
initial amount: NaN

metaR UPPDC1
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/4.1.1.37
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
type: Reaction
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false

metaR DESAT20 1
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
modifier: MODEL1310110064#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_5640fccb_8c5e_4c05_9d16_139bd18137f9
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AA081045
is: SBO:0000252
name: _AA081045_1_m
initial concentration: NaN

metaM 1pyr5c m
boundary condition: false
is: C03912
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: HMDB01301
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893

metaR RE2658R
is described by: ECO:0000000
reactant: MODEL1310110064#
fast: false
name: RE2658
is: SBO:0000176
reversible: true
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction

metaR ALAtN1
fast: false
modifier: MODEL1310110064#
is: SBO:0000185
name: Alanine transport (Na, H coupled)
reversible: true
reactant: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110064#

metaR RE2814M
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110064#
name: RE2814

metaR NACHEXA3ly
fast: false
modifier: MODEL1310110064#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

http://identifiers.org/biomodels.db/MODEL1310110064#_9c9b3cf7_8eda_4b9c_b1d4_481ca0f0ed7f
is: Q96IJ6
initial amount: NaN
type: Species
is encoded by: hsa:29926
is: SBO:0000252
constant: false
name: GMPPA
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR SPHS1Pte
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110064#
name: sphingosine-1-phosphate transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ

metaR r0734
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110064#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
fast: false

metaM glcur c
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
boundary condition: false
is: HMDB00127
constant: false
type: Species
initial concentration: 1.0
name: D-glucuronate
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ab97c2f4_eb11_4fc9_8d47_bcff674042a0
name: CA5B
initial amount: NaN
initial concentration: NaN
is: Q9Y2D0
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:11238

metaM idp n
is: CHEBI:58280
is: SBO:0000247
initial amount: NaN
is: HMDB03335
name: IDP(3-)
has only substance units: false
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
initial concentration: 1.0
type: Species

metaM frdp c
is: HMDB00961
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
has only substance units: false
constant: false
is: C00448
name: Farnesyl diphosphate
is: CHEBI:175763
initial amount: NaN

metaM fad r
type: Species
initial concentration: 1.0
is: HMDB01248
constant: false
initial amount: NaN
is: CHEBI:16238
has only substance units: false
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247

metaR NDP7g
is: SBO:0000176
product: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
fast: false
modifier: MODEL1310110064#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reversible: false
is described by: ECO:0000269

metaM 2dr1p c
is: C00672
name: 2-Deoxy-D-ribose 1-phosphate
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01351
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: CHEBI:58576
constant: false
type: Species

metaR PAIL HStn
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110064#
fast: false
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol nuclear transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110064#_d53eab5a_dc36_40e9_85f7_78488ee02636
is encoded by: hsa:AI024818
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: _AI024818_1_c
is: SBO:0000252
initial amount: NaN

metaR GAL3ST11
is: SBO:0000176
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.11
reversible: false
kinetic law: MODEL1310110064#
name: Galactosylceramide sulfotransferase
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
modifier: MODEL1310110064#

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_7cc5debc_3d55_496c_9cf7_f0f273ab8f83
initial concentration: NaN
constant: false
is: O76082
type: Species
is: SBO:0000252
name: SLC22A5
is encoded by: hsa:6584
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_85187f20_05f3_47df_a5a6_f07590c3e774
type: Species
name: _AI285872_1_c
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI285872

http://identifiers.org/biomodels.db/MODEL1310110064#_a4b14920_e7d8_4925_9660_d22b395bbb8f
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9091
name: PIGQ
is: Q9BRB3
initial amount: NaN
boundary condition: true
type: Species

metaR r0932
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
product: MODEL1310110064#
name: Transport reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_01274114_33ec_4dd6_b197_711e3c8cbdb7
is encoded by: hsa:4830
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
name: NME1
is: SBO:0000252
initial concentration: NaN

metaM CE5236 c
is: SBO:0000247
initial amount: NaN
is: HMDB03952
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
type: Species
is: CHEBI:28002
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
has only substance units: false
initial concentration: 1.0

metaR r0735
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false

metaM 13 cis retn r
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
has only substance units: false
name: 13-cis-retinoate
is: HMDB06219
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7847414

metaR 5ADTSTSTERONEtr
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110064#
reversible: true
is described by: ECO:0000000
name: 5 alpha dihydrotesterone intracellular transport
type: Reaction
kinetic law: MODEL1310110064#

metaR 4MOPte
is described by: ECO:0000134
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
is: SBO:0000185
name: Transport of 4-methyl-2-oxopentanoate
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110064#

metaM arachdcoa x
type: Species
has only substance units: false
is: HMDB06523
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: arachidonoyl-CoA(4-)

metaR GLUDxm
modifier: MODEL1310110064#
name: glutamate dehydrogenase (NAD) (mitochondrial)
is: SBO:0000176
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110064#
product: MODEL1310110064#
fast: false
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
type: Reaction

metaR PROSTGE1t
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110064#
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110064#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110064#_9fc599e9_1df8_4bd1_b378_2d49d4f52d80
is: SBO:0000252
initial amount: NaN
name: CS
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:1431
boundary condition: true
is: O75390

metaR r0931
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110064#
name: Transport reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110064#

metaR r0732
reversible: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
fast: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaM ump n
type: Species
is: HMDB00288
name: UMP(2-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
is: CHEBI:57865
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r0885
modifier: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
reversible: true
reactant: MODEL1310110064#
type: Reaction

metaM glcur e
constant: false
boundary condition: false
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
is: SBO:0000247
name: D-glucuronate
has only substance units: false
initial amount: NaN
is: CHEBI:15748
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110064#_857b82ea_c7f0_4cd2_a0e0_618a6b846dff
name: ALDH3B1
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:221
initial concentration: NaN
boundary condition: true
is: P43353
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_3eaef0fa_4c00_4780_8c93_d770793b36e4
has only substance units: false
constant: false
is: SBO:0000252
is: B4DZR2
type: Species
boundary condition: true
is encoded by: hsa:8854
initial amount: NaN
initial concentration: NaN
name: ALDH1A2

metaR HDCAtr
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110064#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#

metaM odecoa c
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:3793
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR NDPK3m
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is: SBO:0000176

metaR CSEPASEly
reversible: false
product: MODEL1310110064#
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110064#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110064#

metaR NDPK10n
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_5c326fd0_3c49_4d0d_ab8c_1cd6570321ad
type: Species
has only substance units: false
name: EHHADH
constant: false
is: SBO:0000252
is: Q9NY65
initial amount: NaN
boundary condition: true
is encoded by: hsa:1962
initial concentration: NaN

metaR EX 3ump LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-UMP(2-) exchange
type: Reaction

metaR URATEtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110064#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
name: urate export from peroxisome
kinetic law: MODEL1310110064#
reversible: false
fast: false

metaM 3pg c
has only substance units: false
is: HMDB00807
boundary condition: false
is: SBO:0000247
name: 3-Phospho-D-glycerate
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3497
constant: false
is: CHEBI:58272
type: Species
is: C00197
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_af995c07_21a7_46d5_93c2_27aeab80f591
type: Species
name: _AI601100_1_m
initial concentration: NaN
is encoded by: hsa:AI601100
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaR r0733
reversible: false
reactant: MODEL1310110064#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_ca420274_c07f_414f_ac43_734282a6b43a
name: HMGCLL1
initial concentration: NaN
is: Q9NT06
is encoded by: hsa:54511
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_7658fc15_ced4_4a8d_93b2_e9ef4a0e3edb
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:126129
initial amount: NaN
is: Q8TCG5
has only substance units: false
name: CPT1C
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_08cd4416_2309_431c_b62f_072f89da7e6a
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: HMGCL
is encoded by: hsa:3155
is: Q6IBC0
initial concentration: NaN
constant: false
type: Species

metaR GLXtp
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110064#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110064#
name: glyoxylate transport, peroxisomal
type: Reaction
product: MODEL1310110064#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110064#_013ef6d8_7d5f_407e_a3e9_32695273d32d
name: CA12
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:771
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_ec674b34_5256_4f2a_bf57_f62c45eb972d
name: _AF080579_1_c
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:AF080579

metaR r0181
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110064#_eb8252a3_8a1b_457e_8804_209235279c82
boundary condition: true
type: Species
has only substance units: false
is: B7Z3W8
name: SLC6A9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6536
constant: false
initial concentration: NaN

metaR r1492
product: MODEL1310110064#
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: false
type: Reaction
is: SBO:0000185
fast: false
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110064#_96f5b173_e6eb_4ff5_9d8d_73da779d5eee
has part: O94777
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:9091
is encoded by: hsa:8818
initial amount: NaN
has part: Q92535
is encoded by: hsa:51227
is encoded by: hsa:5277
has part: Q9BRB3
has part: Q14442
is: SBO:0000297
is encoded by: hsa:5283
is encoded by: hsa:5279
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
has part: B3KUV7

metaM dcholcoa c
is: CHEBI:28701
constant: false
name: chenodeoxycholoyl coenzyme a
type: Species
is: HMDB06292
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0

metaM C05279 m
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:28387
type: Species
initial amount: NaN
is: HMDB11123
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279

metaR MAN6PI
is version of: http://identifiers.org/ec-code/5.3.1.8
kinetic law: MODEL1310110064#
name: mannose-6-phosphate isomerase
reversible: true
fast: false
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110064#
product: MODEL1310110064#
is: SBO:0000176
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_450b4ebc_41bc_4bfe_9242_1e7ca739ae3a
constant: false
name: SLC5A7
is encoded by: hsa:60482
boundary condition: true
has only substance units: false
is: Q9GZV3
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_7449d870_562e_4f63_b52b_b7cf323664bb
name: IDH2
is: P48735
type: Species
is encoded by: hsa:3418
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaM 10fthf5glu e
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](5)
constant: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: HMDB00972
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57454

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM hpyr c
name: 3-hydroxypyruvate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01352
boundary condition: false
constant: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
type: Species
is: CHEBI:17180

http://identifiers.org/biomodels.db/MODEL1310110064#_c4880019_3a48_498e_a196_5b4ea0007113
has only substance units: false
is: Q02218
boundary condition: true
type: Species
is encoded by: hsa:4967
name: OGDH
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110064#_ca853075_261b_4c46_b47b_6afddbf8a2d4
is: Q16822
name: PCK2
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5106
has only substance units: false
type: Species

metaM retinal c
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
type: Species
is: SBO:0000247
boundary condition: false
name: retinal
is: HMDB01358
is: CHEBI:15035
initial concentration: 1.0

metaM ura c
is: CHEBI:17568
is: C00106
name: Uracil
has only substance units: false
is: SBO:0000247
is: HMDB00300
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_f5db60c9_670e_479a_945d_46e30845ba4b
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6785
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ELOVL4
is: Q9GZR5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_e04a4b04_c9d9_4640_bc77_45c12d14b959
name: MYO5B
type: Species
initial concentration: NaN
is: Q9H6Y6
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4645
constant: false
has only substance units: false
boundary condition: true

metaR HMGLm
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110064#
name: hydroxymethylglutaryl-CoA lyase
is version of: http://identifiers.org/ec-code/4.1.3.4
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
fast: false
modifier: MODEL1310110064#
reversible: false
is: SBO:0000176
product: MODEL1310110064#
reactant: MODEL1310110064#

metaM pap c
is: HMDB00061
initial concentration: 1.0
initial amount: NaN
name: adenosine 3',5'-bismonophosphate(4-)
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: CHEBI:58343
is: SBO:0000247
constant: false

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR r1569
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110064#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SERtN1
modifier: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reversible: true
name: Serine transport (Na, H coupled)
fast: false
kinetic law: MODEL1310110064#
type: Reaction
product: MODEL1310110064#
is: SBO:0000185

metaR 4ABUTtm
is described by: ECO:0000000
kinetic law: MODEL1310110064#
name: 4-aminobutanoate mitochondrial transport via diffusion
fast: false
reactant: MODEL1310110064#
product: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110064#_8d873b03_9b5c_42ac_95b6_ed59a7e4aa1e
type: Species
is encoded by: hsa:386757
boundary condition: true
initial amount: NaN
name: SLC6A10P
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_9cf50c46_93e3_4582_8488_489b1ef439d4
constant: false
is: A0PJJ9
initial amount: NaN
name: GGT7
boundary condition: true
is encoded by: hsa:2686
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaM em2emgacpail hs r
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB03125
is: SBO:0000247
initial amount: NaN
constant: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
is: CHEBI:16240
type: Species
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR r0730
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110064#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reversible: false
reactant: MODEL1310110064#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM leuktrF4 e
name: leukotriene F4
is: CHEBI:27491
constant: false
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
has only substance units: false
is: HMDB06465
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR RE1573M
name: RE1573
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reversible: true

metaR GGH 10FTHF5GLUe
type: Reaction
modifier: MODEL1310110064#
reversible: false
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000000
product: MODEL1310110064#
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

metaM gua e
type: Species
is: HMDB00132
name: guanine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16235
has only substance units: false
constant: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242

http://identifiers.org/biomodels.db/MODEL1310110064#_c039f9ca_5869_4782_b819_d74725242aba
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: P40926
is encoded by: hsa:4191
initial amount: NaN
is: SBO:0000252
name: MDH2

metaR r1568
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000

metaR NDPK3n
fast: false
reactant: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
is described by: ECO:0000304
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110064#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110064#_096850b9_4c71_452f_a8df_a9646493df8f
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: CHPT1
initial amount: NaN
is: Q8WUD6
boundary condition: true
is encoded by: hsa:56994

metaM 2mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
is: HMDB02054
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57337
name: 2-methylcrotonoyl-CoA(4-)

metaR BAAT2x
fast: false
reactant: MODEL1310110064#
is described by: ECO:0000269
product: MODEL1310110064#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
name: bile acid Coenzyme A: amino acid N-acyltransferase
modifier: MODEL1310110064#
type: Reaction

metaR r0731
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
type: Reaction
is: SBO:0000176
reversible: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
product: MODEL1310110064#

metaR PPD2CSPp
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reactant: MODEL1310110064#
is: SBO:0000176
reversible: false
name: PPD2CSPp
fast: false
product: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_cbdcf399_22db_41d2_be79_fc436b15f616
is: SBO:0000252
name: GCNT1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:2650
is: Q02742
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR BHBtm
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
kinetic law: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110064#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
product: MODEL1310110064#

metaR GACMTRc
notes: GENE_ASSOCIATION: (2593.1) or (2593.2) SUBSYSTEM: Urea cycle EC Number: 2.1.1.2 Confidence Level: 4 AUTHORS: PMID:2001229 NOTES:SAB c
is version of: http://identifiers.org/ec-code/2.1.1.2
modifier: MODEL1310110064#
product: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
fast: false
name: guanidinoacetate N-methyltransferase (c)
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

metaR r2030
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
product: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
kinetic law: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_ec64155e_5d83_42dd_82a4_1ad856afe27c
is encoded by: hsa:56848
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: SPHK2
is: Q9NRA0
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_083bed92_93f8_46ea_bc6f_87c198fb8f8b
is encoded by: hsa:94005
has part: O43292
is: SBO:0000297
is encoded by: hsa:128869
has only substance units: false
has part: Q9H490
initial concentration: NaN
has part: Q8NBL9
name: PIGK:PIGU:PIGT:GPAA1:PIGS
is encoded by: hsa:10026
constant: false
is encoded by: hsa:51604
has part: Q92643
has part: Q969N2
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:8733

http://identifiers.org/biomodels.db/MODEL1310110064#_ec6b925c_47c1_404b_864e_9ed02cbd6346
name: AKR7A2
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O43488
is encoded by: hsa:8574
initial concentration: NaN
type: Species

metaR r1567
reactant: MODEL1310110064#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110064#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110064#

metaR RE0577C
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reversible: true
reactant: MODEL1310110064#
name: RE0577
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110064#

metaR NRPPHRtu
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is: SBO:0000185
reversible: true
name: Norepinephrine uniport
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110064#

metaM ile L m
constant: false
boundary condition: false
type: Species
is: HMDB00172
is: CHEBI:17191
initial amount: NaN
initial concentration: 1.0
name: L-isoleucine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaM cs a deg1 l
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
is: HMDB00812
is: CHEBI:16953
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial amount: NaN

metaR r0463
type: Reaction
kinetic law: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
product: MODEL1310110064#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110064#

metaR 4HGLSDm
fast: false
is: SBO:0000176
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
product: MODEL1310110064#
type: Reaction
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000212

metaM C05965 e
is: HMDB04243
is: CHEBI:57444
initial amount: NaN
has only substance units: false
type: Species
name: 12(S)-HPETE(1-)
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM dhap x
is: C00111
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
type: Species
name: Dihydroxyacetone phosphate
is: HMDB01473
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR SGALSIDEtl
name: sgalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
kinetic law: MODEL1310110064#
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
is described by: ECO:0000000
type: Reaction

metaR CYSTGLUex
name: L-cystine/L-glutamate exchanger
is: SBO:0000185
reactant: MODEL1310110064#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
type: Reaction
is described by: ECO:0000269
product: MODEL1310110064#
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#

metaR FAOXC1811603m
is: SBO:0000176
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_85e42e51_ff4f_4931_8190_7e5f6267e028
is: SBO:0000252
type: Species
name: AKR1B1
initial amount: NaN
constant: false
is: P15121
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:231

metaR r1566
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110064#_862e89d7_1aad_48b9_b2e2_9404c68907e2
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AA532636
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: _AA532636_1_m

metaM dhbpt c
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:20680
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
name: 6,7-dihydrobiopterin
constant: false
is: HMDB00038
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110064#_cebb73da_ef6d_4fce_93e6_cd4e3b6ba38f
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:374291
initial concentration: NaN
is: O75251
has only substance units: false
name: NDUFS7
type: Species
boundary condition: true
constant: false

metaM itaccoa m
type: Species
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
constant: false
has only substance units: false
is: HMDB03377
is: CHEBI:57381
name: itaconyl-CoA(5-)
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r0464
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110064#
reversible: true
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
kinetic law: MODEL1310110064#
product: MODEL1310110064#
fast: false
type: Reaction
is: SBO:0000176

metaR CHOLt4
product: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000185
name: choline, sodium cotransport
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
reactant: MODEL1310110064#
fast: false
reversible: true

metaM pap g
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
has only substance units: false
is: CHEBI:58343
is: SBO:0000247
is: HMDB00061
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_63d2a5bd_3902_421a_8296_84a59d30a848
has only substance units: false
initial concentration: NaN
name: SLC2A3
is encoded by: hsa:6515
is: P11169
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaR CYTK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110064#
name: cytidylate kinase (dCMP),nuclear
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
reversible: true

metaR RE1448N
type: Reaction
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true
fast: false
kinetic law: MODEL1310110064#
is: SBO:0000176
name: RE1448
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
is described by: ECO:0000000

metaR GLUCYS
notes: GENE_ASSOCIATION: (2729.1) and (2730.1) SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.2
type: Reaction
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
name: Gamma-glutamylcysteine synthetase
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: false
fast: false

metaR S4TASE2ly
reactant: MODEL1310110064#
reversible: true
kinetic law: MODEL1310110064#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
type: Reaction
product: MODEL1310110064#
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.12

metaM strdnccoa m
is: C16163
is: HMDB06519
name: stearidonyl coenzyme A
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
constant: false
is: http://identifiers.org/pubchem.compound/47205473
initial concentration: 1.0

metaR KCCt
fast: false
product: MODEL1310110064#
reactant: MODEL1310110064#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110064#
reversible: true
name: K+-Cl- cotransport
kinetic law: MODEL1310110064#

metaR FAOXC2251836m
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
name: Beta oxidation of fatty acid
reactant: MODEL1310110064#
modifier: MODEL1310110064#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110064#
is: SBO:0000176

metaM hLkynr c
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
name: 3-hydroxy-L-kynurenine
is: SBO:0000247
type: Species
is: HMDB11631
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:17380
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110064#_dab9abbd_c99e_4cf4_b3d4_3a27c7609718
boundary condition: true
type: Species
initial concentration: NaN
name: SLC25A15
is: SBO:0000252
constant: false
is encoded by: hsa:10166
initial amount: NaN
has only substance units: false
is: Q9Y619

http://identifiers.org/biomodels.db/MODEL1310110064#_a3f75a3f_c1fd_46a0_81fe_08349aeca7cb
is encoded by: hsa:8525
has only substance units: false
is: SBO:0000252
is: G3V0F6
initial concentration: NaN
initial amount: NaN
constant: false
name: DGKZ
boundary condition: true
type: Species

metaM CE1617 r
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01358
boundary condition: false
type: Species
name: 9-cis-retinoate
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
is: CHEBI:17898

metaR r0668
reactant: MODEL1310110064#
product: MODEL1310110064#
modifier: MODEL1310110064#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.19
type: Reaction
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
fast: false
reversible: true
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
kinetic law: MODEL1310110064#
is: SBO:0000176

metaR SO4tl
product: MODEL1310110064#
fast: false
kinetic law: MODEL1310110064#
is described by: ECO:0000269
name: Sulfate transport (lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110064#
is: SBO:0000185

metaR r0443
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
modifier: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110064#
type: Reaction

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR ASNtm
kinetic law: MODEL1310110064#
reversible: false
name: L-asparagine transport, mitochondrial
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV

metaM 3hibutcoa m
is: HMDB01052
constant: false
initial amount: NaN
name: (S)-3-Hydroxyisobutyryl-CoA
is: CHEBI:28259
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000

metaR r1565
kinetic law: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM man6p c
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: CHEBI:17369
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01078
name: D-Mannose 6-phosphate
type: Species
has only substance units: false

metaM 3pg m
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00807
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: CHEBI:58272
constant: false
type: Species
is: SBO:0000247
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate

metaR AMPtp
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
type: Reaction
is: SBO:0000185
reactant: MODEL1310110064#
fast: false
reversible: true
kinetic law: MODEL1310110064#
product: MODEL1310110064#
name: AMP transporter, peroxisome

metaR r2035
reactant: MODEL1310110064#
fast: false
product: MODEL1310110064#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110064#
type: Reaction
kinetic law: MODEL1310110064#

metaM 7thf c
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C49H57N13O24 CHARGE: -8
boundary condition: false
name: heptaglutamyl folate (THF)
constant: false
initial concentration: 1.0
is: CHEBI:17759
is: HMDB00032
has only substance units: false

metaM CE2420 m
is: SBO:0000247
is: HMDB11123
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
has only substance units: false
initial concentration: 1.0
is: CHEBI:28387
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420

metaM HC01403 m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: CHEBI:28325
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA
is: SBO:0000247
type: Species
boundary condition: false
constant: false

metaM ump c
is: CHEBI:57865
name: UMP
constant: false
boundary condition: false
is: C00105
has only substance units: false
is: HMDB00288
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
type: Species

metaR r1564
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110064#
is described by: ECO:0000000
kinetic law: MODEL1310110064#
reversible: true
type: Reaction
fast: false
product: MODEL1310110064#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gthox c
is: C00127
is: HMDB03337
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
name: Oxidized glutathione
is: CHEBI:58297
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

http://identifiers.org/biomodels.db/MODEL1310110064#_4796d6bf_40a4_43ee_9fc1_446692976a63
name: HAS3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3038
type: Species
has only substance units: false
initial concentration: NaN
is: Q96RV2
constant: false
boundary condition: true

metaM clpn hs c
initial amount: NaN
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: HMDB02704
is: CHEBI:21338
has only substance units: false
is: SBO:0000247
constant: false
name: clpn_hs[c]
type: Species

http://identifiers.org/biomodels.db/MODEL1310110064#_81a3f14d_28bd_48ec_b381_78b7f8aae5e4
has only substance units: false
name: ENTPD3
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: O75355
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:956

metaM ura e
initial concentration: 1.0
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
is: HMDB00300
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17568
name: uracil

http://identifiers.org/biomodels.db/MODEL1310110064#_2b095bc5_7098_41af_8a11_34143800d72a
is: SBO:0000252
type: Species
is encoded by: hsa:10568
is: O95436
name: SLC34A2
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110064#_1cf97100_b348_46c9_b4ac_3c8c44dd88b3
boundary condition: true
name: CDO1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: Q16878
is encoded by: hsa:1036
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_224f94a5_4051_4b0a_98a2_dca953433ebe
initial concentration: NaN
boundary condition: true
is: Q53HM1
name: UCKL1
is encoded by: hsa:54963
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110064#_0400b292_6903_4d6a_bd55_3364ec0d6d4e
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P53794
has only substance units: false
is encoded by: hsa:6526
constant: false
type: Species
name: SLC5A3

metaM leuktrF4 c
initial concentration: 1.0
is: CHEBI:27491
initial amount: NaN
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
has only substance units: false
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB06465
name: leukotriene F4

metaR UGALNACtg
fast: false
reversible: true
type: Reaction
name: UDP-GalNAc Golgi transport via CMP antiport
modifier: MODEL1310110064#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110064#
product: MODEL1310110064#
reactant: MODEL1310110064#

http://identifiers.org/biomodels.db/MODEL1310110064#_82374f16_14c4_40ac_9b2c_165eefc043e2
is encoded by: hsa:55350
name: VNN3
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM 4aphdob c
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: HMDB00978
is: SBO:0000247
initial amount: NaN
is: CHEBI:58147
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
type: Species
constant: false

metaR BTNt2
kinetic law: MODEL1310110064#
fast: false
modifier: MODEL1310110064#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
reversible: true
reactant: MODEL1310110064#
product: MODEL1310110064#
is described by: ECO:0000269
name: Biotin reversible transport via proton symport
is: SBO:0000185
type: Reaction

metaM nrpphr e
name: Norepinephrine
constant: false
is: CHEBI:33569
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00216
type: Species
initial amount: NaN
is: SBO:0000247

metaR NACASPAH
modifier: MODEL1310110064#
is described by: ECO:0000269
product: MODEL1310110064#
is: SBO:0000176
type: Reaction
name: N-Acetyl-L-aspartate amidohydrolase
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.15
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
fast: false

metaR r1563
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110064#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
type: Reaction

metaM CE2431 m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
boundary condition: false
constant: false
is: CHEBI:57795
type: Species
has only substance units: false
name: cis-deca-4-enoyl-CoA

metaR UMPK7n
is: SBO:0000176
type: Reaction
name: UMP kinase (dGTP),nuclear
modifier: MODEL1310110064#
kinetic law: MODEL1310110064#
product: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR r0441
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
modifier: MODEL1310110064#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110064#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110064#
reversible: true
reactant: MODEL1310110064#

metaR SADT
modifier: MODEL1310110064#
name: sulfate adenylyltransferase
reactant: MODEL1310110064#
is version of: http://identifiers.org/ec-code/2.7.1.25
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110064#
product: MODEL1310110064#
type: Reaction
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269

metaR r0517
product: MODEL1310110064#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110064#
type: Reaction
modifier: MODEL1310110064#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110064#

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110064#
reactant: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR r1562
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110064#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110064#
reactant: MODEL1310110064#
reversible: true

metaM arachdcoa r
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
name: arachidonoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57368

metaR GALASE19ly
modifier: MODEL1310110064#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110064#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110064#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
kinetic law: MODEL1310110064#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM lthstrl r
name: 5alpha-cholest-7-en-3beta-ol
constant: false
is: CHEBI:17168
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01170
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189

http://identifiers.org/biomodels.db/MODEL1310110064#_14925fcf_a910_4de3_8d63_91ab684ac3ad
initial amount: NaN
type: Species
is: O00217
is: SBO:0000252
has only substance units: false
name: NDUFS8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4728
constant: false

metaR PRPPS
product: MODEL1310110064#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.6.1
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110064#
reactant: MODEL1310110064#
fast: false
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: phosphoribosylpyrophosphate synthetase
kinetic law: MODEL1310110064#

metaM gua c
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: CHEBI:16235
is: HMDB00132
name: Guanine
initial amount: NaN
boundary condition: false
is: C00242
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110064#_290e47d2_da77_4076_8526_86308a1d6c9f
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9NUD9
name: PIGV
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:55650

http://identifiers.org/biomodels.db/MODEL1310110064#_e1e23453_885a_4555_93de_4c270f034bc2
has only substance units: false
type: Species
is: SBO:0000252
is: P50440
is encoded by: hsa:2628
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GATM

http://identifiers.org/biomodels.db/MODEL1310110064#_eba1f848_5e3e_447e_8671_73d5e79d54b8
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC46A1
is: Q96NT5
boundary condition: true
is encoded by: hsa:113235
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110064#_3b2a44db_3dc9_4128_b9d0_cfc7484192f2
initial amount: NaN
constant: false
initial concentration: NaN
is: P04746
type: Species
is encoded by: hsa:279
boundary condition: true
is: SBO:0000252
has only substance units: false
name: AMY2A

metaR r0669
product: MODEL1310110064#
is: SBO:0000176
reactant: MODEL1310110064#
kinetic law: MODEL1310110064#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
type: Reaction
reversible: false
fast: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17

metaM ump e
name: UMP(2-)
is: HMDB00288
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
is: CHEBI:57865

metaM prpp e
constant: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00280
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM Tn antigen l
name: Tn antigen
type: Species
has only substance units: false
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false
is: C04383
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN