metaM oxa m
constant: false
initial concentration: 1.0
is: SBO:0000247
name: oxalate(2-)
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623

metaM tyr L e
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: HMDB00158
name: L-tyrosine
is: CHEBI:17895
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false

metaM ha e
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
name: hyaluronan
is: CHEBI:16336

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM orot c
is: CHEBI:30839
boundary condition: false
has only substance units: false
constant: false
is: HMDB00226
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: C00295
initial amount: NaN

metaR FAOXC185m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_34598d44_116c_475d_a6e1_e568f3b0e10b
is: P50336
initial amount: NaN
is encoded by: hsa:5498
constant: false
initial concentration: NaN
name: PPOX
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252

metaR MMEm
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
modifier: MODEL1310110062#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110062#
name: methylmalonyl-CoA epimerase/racemase
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.99.1
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_6d97492c_0bb8_4403_99f3_af771e1ff00d
has only substance units: false
is: A8K3J4
constant: false
is encoded by: hsa:23632
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: CA14

metaM mev R c
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:36464
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: SBO:0000247
boundary condition: false
name: (R)-mevalonate
is: HMDB00227

http://identifiers.org/biomodels.db/MODEL1310110062#_d3e9f35a_6249_429b_9282_2b0473f89658
is encoded by: hsa:54675
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CRLS1
is: Q9UJA2

metaM tymsf c
boundary condition: false
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: HMDB06409
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
name: Tyramine O-sulfate

metaR TYRTA
type: Reaction
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110062#
reversible: true
is: SBO:0000176
name: tyrosine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_5089e0a7_107d_4846_b33d_db972f98d883
name: PPA2
is encoded by: hsa:27068
type: Species
boundary condition: true
initial amount: NaN
is: Q9H2U2
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaR DCSPTN1t
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110062#
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
reversible: true

metaR SIAASE2ly
type: Reaction
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110062#
fast: false
name: sialidase, lysosomal
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_2d2eb0f0_19d7_485c_91d9_9c86485d2563
type: Species
name: _H17063_1_c
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:H17063
initial amount: NaN
has only substance units: false
boundary condition: true

metaM CE4633 e
constant: false
initial concentration: 1.0
is: CHEBI:24757
is: SBO:0000247
type: Species
notes: FORMULA: ClHO CHARGE: 0 INCHI: InChI=1S/ClHO/c1-2/h2H EHMN_ABBREVIATION: CE4633
has only substance units: false
boundary condition: false
initial amount: NaN
name: hypochlorous acid

http://identifiers.org/biomodels.db/MODEL1310110062#_6c4b7383_84cf_46f1_8af2_08c225094484
constant: false
type: Species
is encoded by: hsa:788
initial amount: NaN
is: O43772
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC25A20

http://identifiers.org/biomodels.db/MODEL1310110062#_ac05f8c8_a771_424a_af32_028c441a6843
boundary condition: true
initial amount: NaN
has only substance units: false
name: PCBD1
is encoded by: hsa:5092
type: Species
is: SBO:0000252
constant: false
is: P61457
initial concentration: NaN

metaM asn L e
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB00168
is: CHEBI:17196
name: L-asparagine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_12720586_3e10_42bf_bf74_1351a63cfdcc
type: Species
name: ATG9B
has only substance units: false
initial concentration: NaN
is encoded by: hsa:285973
is: Q674R7
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR ALASERNaEx
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185

metaR GPIDA2er
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
reversible: false
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction

metaM so3 c
has only substance units: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial concentration: 1.0
initial amount: NaN
is: HMDB00240
name: Sulfite
constant: false
is: C00094
is: CHEBI:17137
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_87416e7e_0127_4810_b989_ebcda0f3ee38
name: NME1:NME2
has part: P15531
has part: P22392
is encoded by: hsa:4830
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:4831

metaR r1380
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
product: MODEL1310110062#
fast: false
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: true

metaM gdpfuc c
boundary condition: false
constant: false
is: CHEBI:57984
is: SBO:0000247
name: GDP-L-fucose(2-)
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01095
initial concentration: 1.0
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

metaR FAOXC102C81m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaM dhap x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
has only substance units: false
is: CHEBI:57642
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01473
boundary condition: false
type: Species
is: C00111
name: Dihydroxyacetone phosphate

metaM adrncrn c
notes: FORMULA: C29H49NO4 CHARGE: 0
boundary condition: false
has only substance units: false
is: HMDB00062
initial amount: NaN
is: C00318
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Adrenyl carnitine
is: CHEBI:16347
type: Species

metaM o2 m
initial concentration: 1.0
is: C00007
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: CHEBI:15379
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: O2
has only substance units: false

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaR ABO4g
product: MODEL1310110062#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110062#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37

metaR r1381
is: SBO:0000176
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: true
is described by: ECO:0000000
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5

metaR r1670
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
type: Reaction

metaR MI1345PP
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110062#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36

http://identifiers.org/biomodels.db/MODEL1310110062#_7832953b_40c2_4a34_987b_8d5ce1c0ddaf
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: LDHD
constant: false
is: Q86WU2
is encoded by: hsa:197257
type: Species
is: SBO:0000252

metaM fprica c
constant: false
is: HMDB01439
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C04734
type: Species
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
initial amount: NaN
is: CHEBI:58467

metaM asn L c
is: CHEBI:17196
boundary condition: false
name: L-asparagine
initial concentration: 1.0
is: HMDB00168
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
type: Species
is: SBO:0000247
constant: false

metaR ADSS
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.4
fast: false
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reversible: false
kinetic law: MODEL1310110062#
name: adenylosuccinate synthase
product: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000134

metaR r0639
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
fast: false
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false
reactant: MODEL1310110062#
is: SBO:0000176

metaM ppi x
is: CHEBI:33019
initial amount: NaN
has only substance units: false
is: C00013
name: Diphosphate
constant: false
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR MCCCrm
is: SBO:0000176
modifier: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
reactant: MODEL1310110062#
name: methylcrotonoyl-CoA carboxylase, mitochondrial
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/6.4.1.4

metaR ACNACNGAL14ACGLCGALGLUSIDEte
reactant: MODEL1310110062#
is described by: ECO:0000000
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_7f29dad5_cdf5_45fb_b6c7_9ed3283bca97
name: ATP5G3
type: Species
boundary condition: true
is encoded by: hsa:518
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR biomass reaction
reactant: MODEL1310110062#
name: Generic human biomass reaction
product: MODEL1310110062#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110062#
reversible: false
is described by: ECO:0000134
fast: false

metaR ADSK
is: SBO:0000176
product: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.25
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110062#
reversible: false
type: Reaction
reactant: MODEL1310110062#
name: adenylyl-sulfate kinase

http://identifiers.org/biomodels.db/MODEL1310110062#_03b503ba_3f2e_4260_b651_9271e3cddadd
initial concentration: NaN
name: ALDH4A1
constant: false
has only substance units: false
is encoded by: hsa:8659
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r1459
type: Reaction
name: Transport reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110062#

metaR ASPPROASCT1
reactant: MODEL1310110062#
type: Reaction
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
product: MODEL1310110062#
is described by: ECO:0000134
reversible: false
is: SBO:0000185
name: aspartate intake by system ASCT-1 transporter

metaR r1671
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: true
modifier: MODEL1310110062#

metaM CE1935 e
is: CHEBI:16301
is: HMDB02786
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: spermine monoaldehyde
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935

metaM ru5p D r
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: CHEBI:58121
type: Species
has only substance units: false
name: D-ribulose 5-phosphate(2-)
boundary condition: false
is: HMDB00618
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR RE0453C
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110062#
fast: false
is described by: ECO:0000000
name: RE0453
is: SBO:0000176

metaM acgbgbside hs c
is: SBO:0000247
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
initial concentration: 1.0
is: CHEBI:17411
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00215
name: beta GalNAc globoside
type: Species
boundary condition: false

metaR TDCHOLAte
is described by: ECO:0000000
name: bile acid intracellular transport
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
product: MODEL1310110062#
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_589cecbf_dd3b_41bd_959e_17d3403ee402
is: P30837
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:219
initial concentration: NaN
name: ALDH1B1
has only substance units: false
type: Species
is: SBO:0000252

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_a19754a4_2fab_49f9_b075_1033a68f9680
initial concentration: NaN
is encoded by: hsa:220
constant: false
initial amount: NaN
type: Species
name: ALDH1A3
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P47895

metaR RE1516M
name: RE1516
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110062#

metaR NACHEXA17ly
reversible: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal

metaM decdicrn c
name: decadienoyl carnitine
notes: FORMULA: C17H29NO4 CHARGE: 0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: HMDB13325
initial concentration: 1.0
type: Species

metaR C142OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

metaM lys L e
initial amount: NaN
is: HMDB00182
constant: false
type: Species
name: L-lysinium(1+)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
initial concentration: 1.0
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110062#_c6211556_4986_41e8_98f6_513a3787e44d
type: Species
is: Q6ZWT7
name: MBOAT2
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:129642
boundary condition: true

metaM ksi pre3 g
has only substance units: false
initial amount: NaN
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: HMDB00175
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 3
boundary condition: false
type: Species
initial concentration: 1.0
is: C00130
constant: false
is: CHEBI:58053

metaM o2s m
type: Species
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:18421
name: Superoxide anion
is: HMDB02168
is: C00704
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_897ad91c_e838_4294_a1be_e8863f11fd56
constant: false
is: SBO:0000252
initial amount: NaN
is: P11169
name: SLC2A3
has only substance units: false
type: Species
is encoded by: hsa:6515
boundary condition: true
initial concentration: NaN

metaM ppp9 m
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
is: HMDB00241
type: Species
initial concentration: 1.0
has only substance units: false
name: Protoporphyrin
initial amount: NaN
constant: false
is: CHEBI:36159
is: SBO:0000247
boundary condition: false

metaM 3ohdcoa m
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: HMDB06402
is: CHEBI:57349
name: 3-oxopalmitoyl-CoA(4-)
initial amount: NaN
constant: false

metaM tyr L c
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
type: Species
has only substance units: false
name: L-tyrosine
initial concentration: 1.0
is: HMDB00158
boundary condition: false
is: CHEBI:17895
is: SBO:0000247
initial amount: NaN

metaM gdpfuc g
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false
name: GDP-L-fucose(2-)
initial amount: NaN
constant: false
is: CHEBI:57984
type: Species
is: SBO:0000247
is: HMDB01095
initial concentration: 1.0

metaR r1384
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
reversible: true
name: Guanosine aminohydrolase EC:3.5.4.15
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
is: SBO:0000176
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_9e4dc8ea_9695_469b_8531_3e72e8574ebb
name: _U52111_1_c
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:U52111
is: SBO:0000252

metaR GALASE17ly
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reversible: false
type: Reaction

metaM malcoa r
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
constant: false
is: HMDB01175
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57384
type: Species
has only substance units: false
name: malonyl-CoA(4-)
initial amount: NaN

metaR AG13T16g
reversible: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#

metaR FAOXC16C14m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_ed9db64f_4798_4d7d_a96b_316d41aacbdf
has only substance units: false
is encoded by: hsa:65263
boundary condition: true
type: Species
is: Q53H96
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: PYCRL

http://identifiers.org/biomodels.db/MODEL1310110062#_440e4a8a_90b6_48c3_9cb8_1372721a873c
is: Q53XN1
name: COX8A
initial concentration: NaN
is encoded by: hsa:1351
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaR RE3346M
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110062#
name: RE3346
fast: false
modifier: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:

metaM dhor S c
initial amount: NaN
boundary condition: false
is: CHEBI:30864
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB03349
initial concentration: 1.0
name: (S)-dihydroorotate

http://identifiers.org/biomodels.db/MODEL1310110062#_4aaf5c7e_e31e_44fc_b7c7_71b737e088d5
type: Species
constant: false
has only substance units: false
is: Q16853
is encoded by: hsa:8639
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: AOC3
boundary condition: true

metaR ACGBGBSIDEtg
fast: false
is: SBO:0000185
product: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: acgbgbside hs intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_d739abf9_fe29_444e_97b2_435bd1a30524
initial amount: NaN
is encoded by: hsa:84720
has only substance units: false
constant: false
name: PIGO
type: Species
initial concentration: NaN
boundary condition: true
is: Q8TEQ8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_c3b012a2_9001_4e1b_a6e4_fdcccb85175f
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: CDIPT
is encoded by: hsa:10423
type: Species
is: A8K3L7
boundary condition: true
constant: false
initial concentration: NaN

metaM icit c
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial concentration: 1.0
initial amount: NaN
is: HMDB00193
is: C00311
name: Isocitrate
is: CHEBI:16087
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR FAOXC18480m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
name: Beta oxidation of fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110062#
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_c20fa40f_c5a0_462e_8afb_92e64062d6da
is encoded by: hsa:386757
is: SBO:0000252
type: Species
has only substance units: false
name: SLC6A10P
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaM prpncoa m
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB02307
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: SBO:0000247
name: acryloyl-CoA(4-)
constant: false
type: Species
is: CHEBI:57367

metaR C142OHe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaR RE1573M
modifier: MODEL1310110062#
name: RE1573
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000

metaR r1675
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110062#
type: Reaction
reversible: false
is: SBO:0000185

metaM ppi m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
type: Species
initial amount: NaN
name: Diphosphate
is: HMDB00250
is: C00013

metaM o2 c
initial concentration: 1.0
is: SBO:0000247
is: HMDB01377
name: O2
has only substance units: false
is: CHEBI:15379
type: Species
boundary condition: false
constant: false
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN

metaR HOXG
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.14.99.3
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
type: Reaction
name: Heme oxygenase 1
reversible: false
product: MODEL1310110062#

metaR r0634
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
fast: false
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.1
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_872dd936_a8c7_47a4_a6e2_43f081c56e66
type: Species
is: P27986
is encoded by: hsa:5295
has only substance units: false
name: PIK3R1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaR TRIODTHYt2
is: SBO:0000185
modifier: MODEL1310110062#
name: T3 transport via facilitated diffusion
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
type: Reaction
reversible: true
fast: false
product: MODEL1310110062#

metaR r1889
is described by: ECO:0000000
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: false
type: Reaction
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM 3ttetddcoacrn c
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C21H37NO5 CHARGE: 0
has only substance units: false
boundary condition: false
is: HMDB02014
initial concentration: 1.0

metaR UDPDOLPT L
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.117
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
modifier: MODEL1310110062#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000176
fast: false
reactant: MODEL1310110062#
reversible: false
type: Reaction

metaR ICDHyrm
reversible: true
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
name: Isocitrate dehydrogenase (NADP+)
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
modifier: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_f7976063_0657_4eab_a61b_19501bec25ae
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10797
initial amount: NaN
has only substance units: false
name: MTHFD2
is: P13995
is: SBO:0000252
type: Species
constant: false

metaM vacc c
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
name: trans-vaccenate
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: CHEBI:30828
initial concentration: 1.0
has only substance units: false
is: C08367

metaR CGLYt3 2
product: MODEL1310110062#
name: Cys-Gly transport in via proton symport
reactant: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
reversible: false
type: Reaction
modifier: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB

metaM HC01397 m
name: (S)-3-Hydroxyhexadecanoyl-CoA
has only substance units: false
is: CHEBI:27402
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r0633
type: Reaction
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.7.3
reversible: true

metaR CORE4GTg
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
product: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#

metaM dhap m
is: C00111
boundary condition: false
is: HMDB01473
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3411
type: Species
initial concentration: 1.0
has only substance units: false
name: Dihydroxyacetone phosphate
initial amount: NaN

metaM ppi n
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:33019
type: Species
initial amount: NaN
name: diphosphate(3-)
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110062#_fc8ee580_e3f8_4877_95df_2bac77998d3a
is encoded by: hsa:1854
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: DUT
is: P33316
constant: false

metaR 2HBt2
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
reversible: true
name: 2-hydroxybutyrate cotransport with proton
type: Reaction
product: MODEL1310110062#

metaR M16NTg
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
modifier: MODEL1310110062#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.143

metaM core6 l
boundary condition: false
name: Core 6
has only substance units: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: HMDB00143
is: CHEBI:12936
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

metaM f6p c
is: CHEBI:57579
name: D-Fructose 6-phosphate
boundary condition: false
is: HMDB00124
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00085
constant: false
is: http://identifiers.org/pubchem.compound/3385
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_302e424b_c6ca_4df2_b3b9_485c321329fe
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:27124
is: Q15735
is: SBO:0000252
name: INPP5J
initial amount: NaN

metaR PItg
is: SBO:0000185
reversible: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110062#
name: phosphate transport, Golgi apparatus
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_eb6ce3b7_15bf_43fd_9aac_57c0fc5405d1
is: SBO:0000252
is: Q8IXW6
constant: false
name: DPYSL3
type: Species
initial concentration: NaN
is encoded by: hsa:1809
has only substance units: false
boundary condition: true
initial amount: NaN

metaR IDOURtly
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: iduronate transport into lysososme
fast: false
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
is described by: ECO:0000269

metaR DAGK hs
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
name: Diacylglycerol phosphate kinase (homo sapiens)
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.107
reversible: true
is described by: ECO:0000269

metaM o2 e
constant: false
is: C00007
initial concentration: 1.0
has only substance units: false
is: HMDB01377
boundary condition: false
is: SBO:0000247
name: O2
initial amount: NaN
is: CHEBI:15379
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaM ksi deg12 l
has only substance units: false
boundary condition: false
name: keratan sulfate I, degradation product 12
initial amount: NaN
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
is: HMDB00143
is: CHEBI:12936
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM acgal l
type: Species
is: HMDB00212
is: CHEBI:28037
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: N-acetyl-D-galactosamine

http://identifiers.org/biomodels.db/MODEL1310110062#_63f67a0c_a21f_4ba2_9c65_5921afb92a47
is: Q5JZF5
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: ALAS2
type: Species
has only substance units: false
is encoded by: hsa:212

metaR r1453
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
product: MODEL1310110062#
fast: false
reversible: true
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000176

metaR PROSTGE2t
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
is described by: ECO:0000269
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#

metaR r2309
kinetic law: MODEL1310110062#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_996c08a4_2a7e_4b52_bba0_03f410b6f66b
initial concentration: NaN
name: SKIV2L2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: Q3MHC9
is encoded by: hsa:23517
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_ad096396_978b_4cdd_bd3b_341ed3d76a84
is: SBO:0000252
has only substance units: false
constant: false
name: AK2
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:204

metaR R group phosphotase 2
name: R group phosphotase 2
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110062#

metaR ACNACNGAL14ACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
name: blood group intracellular transport
type: Reaction
reversible: true

metaR r1156
is: SBO:0000176
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
kinetic law: MODEL1310110062#
type: Reaction
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false

metaR MAN1PT2
modifier: MODEL1310110062#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#
name: mannose-1-phosphate guanylyltransferase (GDP)
type: Reaction
reversible: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.7.13
kinetic law: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR

metaR DHPR2
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
name: 6,7-dihydropteridine reduction
is described by: ECO:0000304
type: Reaction

metaR r1678
kinetic law: MODEL1310110062#
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_1597d5db_1ca0_4110_84b0_26ee8f75c37a
boundary condition: true
has only substance units: false
name: ST3GAL3
type: Species
initial concentration: NaN
is encoded by: hsa:6487
initial amount: NaN
constant: false
is: SBO:0000252

metaR FUT15g
is version of: http://identifiers.org/ec-code/2.4.1.69
name: Galactoside 2-alpha-L-fucosyltransferase 1
modifier: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#
type: Reaction
fast: false
reactant: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ

metaM 3hodcoa c
boundary condition: false
type: Species
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
is: SBO:0000247
is: HMDB13336
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxyoctadecanoyl-CoA
constant: false
initial concentration: 1.0

metaM lys L c
type: Species
has only substance units: false
is: HMDB00182
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:32551

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM decdicrn e
boundary condition: false
initial amount: NaN
is: HMDB13325
type: Species
initial concentration: 1.0
notes: FORMULA: C17H29NO4 CHARGE: 0
name: decadienoyl carnitine
is: SBO:0000247
constant: false
has only substance units: false

metaM ivcrn c
is: HMDB00688
boundary condition: false
has only substance units: false
notes: FORMULA: C12H23NO4 CHARGE: 0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: isovaleryl carnitine

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR r2308
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM cs e deg2 l
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:57455
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
is: HMDB01354
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_fe32b13d_f38f_4898_9d64_fcfe30b6fa3b
is encoded by: hsa:6240
type: Species
has only substance units: false
is: SBO:0000297
has part: P23921
initial amount: NaN
constant: false
has part: P31350
initial concentration: NaN
boundary condition: true
name: RRM1:RRM2
is encoded by: hsa:6241

http://identifiers.org/biomodels.db/MODEL1310110062#_855c0811_78cb_403e_94e0_244be994df36
name: ST3GAL1
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6482
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaR DOLP Lter
reversible: false
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
name: dolichol phosphate flippase (liver)
is: SBO:0000176
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#

metaR r0638
fast: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.2
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000000
reversible: true
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176

metaR r1451
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110062#
name: EC:1.3.3.6
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:

metaR ACGBGBSIDEtl
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
name: acgbgbside hs intracellular transport
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#

metaR C4CRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaM ksi deg23 l
is: CHEBI:12936
type: Species
boundary condition: false
is: HMDB00143
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 23
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r1150
modifier: MODEL1310110062#
reactant: MODEL1310110062#
name: Facilitated diffusion
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
kinetic law: MODEL1310110062#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_7017307f_e931_4314_8eb8_770aecced40a
initial amount: NaN
is: SBO:0000252
name: _286297_1_c
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:286297
has only substance units: false

metaR S6T14g
type: Reaction
kinetic law: MODEL1310110062#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110062#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#

metaR CHSTEROLt2
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: cholesterol intracellular transport
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
reversible: true
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR G14T18g
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110062#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_5519eea5_92a3_44d1_94ff_fd2008d1723e
name: ETFB
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P38117
boundary condition: true
is encoded by: hsa:2109
has only substance units: false
constant: false
type: Species

metaR FAOXC164m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR r0074
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
is: SBO:0000176
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110062#
reactant: MODEL1310110062#

metaM core6 g
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16478
constant: false
name: Core 6
has only substance units: false
initial amount: NaN

metaR IVCRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaM o2s e
initial amount: NaN
has only substance units: false
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: superoxide
boundary condition: false

metaM cl c
is: CHEBI:3966
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00492
constant: false
initial amount: NaN
notes: FORMULA: Cl CHARGE: -1
type: Species
name: Chloride
is: C00115

http://identifiers.org/biomodels.db/MODEL1310110062#_1dcc552c_8346_4952_b133_a24d980f9138
is: P04183
constant: false
name: TK1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7083
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM ppi r
is: HMDB00250
is: CHEBI:33019
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
has only substance units: false
type: Species
name: Diphosphate
boundary condition: false
is: C00013

metaR RE3346C
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: RE3346
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_40bbfbf9_d22c_40a2_a695_51e1068b7335
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:1892
initial amount: NaN
name: ECHS1
has only substance units: false
is: SBO:0000252
is: P30084
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
has only substance units: false
is: CHEBI:61648
initial amount: NaN

metaR CHSTEROLt3
name: cholesterol intracellular transport
fast: false
reversible: true
product: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110062#

metaM icit m
is: C00311
initial amount: NaN
type: Species
initial concentration: 1.0
name: Isocitrate
is: HMDB00193
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
constant: false
is: SBO:0000247
boundary condition: false

metaR R group phosphotase 1
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110062#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110062#
name: R group phosphotase 1
reversible: false

metaM CE1943 e
is: HMDB02786
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16301
initial amount: NaN
boundary condition: false
name: spermidine dialdehyde
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943

http://identifiers.org/biomodels.db/MODEL1310110062#_09b4113a_b496_4a39_817f_7e5b97334ef1
constant: false
initial concentration: NaN
name: _AI971023_1_c
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI971023
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_5fa80491_f863_4f73_931f_b61c50025a6c
constant: false
has only substance units: false
name: TXNRD1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7296
type: Species
initial concentration: NaN
initial amount: NaN

metaM 3ttetddcoacrn e
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C21H37NO5 CHARGE: 0
constant: false
is: SBO:0000247
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
is: HMDB02014

metaR r2519
kinetic law: MODEL1310110062#
is: SBO:0000185
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
product: MODEL1310110062#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110062#

metaM cl e
is: CHEBI:3966
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00492
type: Species
has only substance units: false
is: C00115
notes: FORMULA: Cl CHARGE: -1
name: Chloride

metaM thmmp m
is: SBO:0000247
is: HMDB02666
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
is: CHEBI:37575
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: thiamine(1+) monophosphate(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_726a34bf_b3a5_4978_a84c_c496a84b8745
is: O43916
is encoded by: hsa:8534
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: CHST1
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR HEXCt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110062#
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false

metaM retinal 11 cis c
is: HMDB02152
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:16066
initial amount: NaN
constant: false
boundary condition: false
name: 11-cis-retinal

metaR SPMTDe
reactant: MODEL1310110062#
name: SPMTDe
type: Reaction
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_af476c8b_25a2_4f00_9368_95ccd07a10a2
initial concentration: NaN
name: COX7B2
boundary condition: true
is encoded by: hsa:170712
constant: false
has only substance units: false
is: Q8TF08
type: Species
initial amount: NaN
is: SBO:0000252

metaM ksi pre26 g
type: Species
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 26
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:28067

metaM o2s c
name: superoxide
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:18421
boundary condition: false
has only substance units: false
constant: false
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0

metaR NDP7er
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176

metaM 3thexddcoa m
is: HMDB02014
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
name: 3-hydroxy trans7,10-hexadecadienoylcoa
type: Species
is: SBO:0000247

metaM bilglcur e
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
boundary condition: false
is: CHEBI:57767
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247

metaM acgal c
name: N-acetyl-D-galactosamine
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00212
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28037
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
constant: false

metaM biocyt c
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: HMDB03134
boundary condition: false
is: SBO:0000247
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_2818141f_f571_4691_9c37_6f3d8db7f7cc
constant: false
is encoded by: hsa:92483
type: Species
is: SBO:0000252
is: Q9BYZ2
has only substance units: false
boundary condition: true
initial amount: NaN
name: LDHAL6B
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_aaf127a9_55e9_49f7_84dd_ef51e216ef84
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:116369
name: SLC26A8
initial concentration: NaN
is: SBO:0000252
is: Q96RN1

metaR B3GNT12g
fast: false
reactant: MODEL1310110062#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reversible: false
type: Reaction
modifier: MODEL1310110062#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110062#

metaM so4 m
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
boundary condition: false
is: HMDB01448
initial concentration: 1.0
name: sulfate
is: SBO:0000247
has only substance units: false
is: CHEBI:16189
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_f5077ed5_d8c4_4b6b_8328_35bda0c37943
is: SBO:0000252
name: GNPDA1
is: P46926
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:10007

metaR TYRt4
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110062#
name: L-tyrosine transport in via sodium symport
product: MODEL1310110062#
reversible: false
is: SBO:0000185
reactant: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
type: Reaction

metaM so4 l
boundary condition: false
is: CHEBI:16189
has only substance units: false
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
is: HMDB01448
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false

metaM mmcoa R m
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: (R)-methylmalonyl-CoA(5-)
initial concentration: 1.0
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: CHEBI:57326
is: HMDB01269
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_24ea531e_2222_4a5e_ab4e_5da195097c29
name: ALDH1A2
has only substance units: false
is: B4DZR2
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:8854

metaR FAOXC2251836m
kinetic law: MODEL1310110062#
reversible: false
name: Beta oxidation of fatty acid
reactant: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_0b27f0de_9321_454f_a4a0_2688027959de
has only substance units: false
is: A8K5J1
constant: false
is encoded by: hsa:7372
initial concentration: NaN
type: Species
name: UMPS
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR ITPtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: ITP nuclear transport
is described by: ECO:0000000
reversible: true
product: MODEL1310110062#
type: Reaction
fast: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_5d06d4b1_e102_4892_b3e2_9e1f3ac8919a
is encoded by: hsa:H53099
has only substance units: false
name: _H53099_1_m
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaM c81crn e
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H27NO4 CHARGE: 0
type: Species
constant: false
is: HMDB13324
initial amount: NaN
initial concentration: 1.0
name: octenoyl carnitine

metaM ppi e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:33019
initial amount: NaN
is: HMDB00250
constant: false
has only substance units: false
type: Species
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate

metaR PI45P5P
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000000
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#

metaM dhap e
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: HMDB01473
name: glycerone phosphate(2-)
is: CHEBI:57642
is: SBO:0000247
initial amount: NaN

metaM srtn e
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0
is: CHEBI:350546
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: serotonin(1+)
is: HMDB00259
constant: false
boundary condition: false

metaR HISTAtu
product: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
reversible: true
name: Histamine uniport
kinetic law: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
fast: false
type: Reaction

metaM ksi pre18 g
type: Species
name: keratan sulfate I biosynthesis, precursor 18
is: HMDB00175
initial amount: NaN
is: C00130
is: CHEBI:58053
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM pydx c
is: CHEBI:17310
has only substance units: false
boundary condition: false
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: C00250
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Pyridoxal
is: HMDB01545
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_acc0875d_0c13_487f_bc1e_0aa34ced4fce
boundary condition: true
initial amount: NaN
is encoded by: hsa:8704
name: B4GALT2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_cec1eaef_a7b5_4a1a_9935_2bef2cb0a7d0
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: ATP5F1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:515

metaR FAOXC2051843m
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110062#

metaM biocyt e
is: SBO:0000247
is: HMDB03134
constant: false
initial concentration: 1.0
type: Species
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
is: C05552
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

metaR C161CRNt
is described by: ECO:0000000
product: MODEL1310110062#
name: C161 transport into the mitochondria
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
reversible: false
fast: false
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_4017c637_87e9_4343_89b6_aa46834550c7
boundary condition: true
is encoded by: hsa:10195
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: ALG3
initial amount: NaN
type: Species

metaR r2526
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
product: MODEL1310110062#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110062#

metaR CO2tm
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
name: CO2 transport (diffusion), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_6216e813_ee77_4441_a96b_3184f09319e3
type: Species
name: B3GNT6
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: A8K9Q8
is encoded by: hsa:192134

http://identifiers.org/biomodels.db/MODEL1310110062#_19510917_bbcb_4a9f_9528_dda503fe5404
is encoded by: hsa:2181
name: ACSL3
initial amount: NaN
constant: false
initial concentration: NaN
is: B3KMA6
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR OCTDECCACT
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_33a47614_6357_4c46_9eb6_5a42bcb66cdc
constant: false
initial concentration: NaN
name: ALDH5A1
is encoded by: hsa:7915
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q546H9
type: Species
has only substance units: false

metaR STRDNCt
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_4e302ff0_a4a5_4233_984d_648803437c92
boundary condition: true
initial concentration: NaN
name: SLC16A8
is: SBO:0000252
is encoded by: hsa:23539
initial amount: NaN
has only substance units: false
type: Species
is: O95907
constant: false

metaR CHSTEROLt1
is described by: ECO:0000304
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
fast: false
reversible: true
name: cholesterol intracellular transport
modifier: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_66f5637b_8ac5_470a_80e1_a1ef27113e8f
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: _HG2846_HT2983_1_m
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_e6a16a64_9b83_43df_8f2a_79a997dc3d2a
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9Y619
is encoded by: hsa:10166
name: SLC25A15
boundary condition: true

metaR RE3347C
type: Reaction
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
name: RE3347
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:

metaM dgdp n
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:58595
name: dGDP(2-)
initial concentration: 1.0
boundary condition: false
is: HMDB00960
type: Species

metaR PI4PLCn
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110062#
reversible: false
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.11

metaR ASPDxt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reactant: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
reversible: true
type: Reaction
fast: false
name: D-aspartate transport, peroxisomal
is described by: ECO:0000000
product: MODEL1310110062#

metaR S23T4g
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase
reversible: false
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false

metaR SRTNtu
name: Serotonin uniport
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185

metaM c81crn c
name: octenoyl carnitine
type: Species
constant: false
is: HMDB13324
has only substance units: false
boundary condition: false
notes: FORMULA: C15H27NO4 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR S6T15g
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
kinetic law: MODEL1310110062#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.21
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false

metaM srtn c
is: HMDB00259
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0
has only substance units: false
type: Species
name: serotonin(1+)
is: CHEBI:350546
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_a804e082_7fae_4002_91f6_9724aeb07334
is: Q6GTM5
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: SC5DL
has only substance units: false
is encoded by: hsa:6309
boundary condition: true

metaM taur c
boundary condition: false
initial concentration: 1.0
name: Taurine
has only substance units: false
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
is: SBO:0000247
constant: false
is: CHEBI:3544
initial amount: NaN
is: C00245

metaM octdececrn m
is: http://identifiers.org/pubchem.compound/5280771
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)

metaM gthox c
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
is: SBO:0000247
is: C00127
initial amount: NaN
name: Oxidized glutathione
type: Species
initial concentration: 1.0
is: CHEBI:58297
boundary condition: false
has only substance units: false
is: HMDB03337

metaR NDPK5
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110062#
fast: false
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dGDP)
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#

metaR PI345P3P
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
fast: false
modifier: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.67
type: Reaction
reversible: false
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_eeca0d1b_53c8_4269_b4b2_2eee910553e5
initial amount: NaN
type: Species
constant: false
name: LDHD
is encoded by: hsa:197257
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_f8b756f1_010f_4452_9d8f_e8996d4378aa
is: O95436
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10568
has only substance units: false
boundary condition: true
constant: false
name: SLC34A2
initial concentration: NaN

metaR LEUKTRF4t
reversible: true
is described by: ECO:0000000
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: leukotriene F4 transport
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_cd4608e6_02ce_4fc4_a817_47b977f44f3f
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51022
is: Q9NS18
constant: false
name: GLRX2
initial concentration: NaN

metaM gdp e
initial concentration: 1.0
initial amount: NaN
name: GDP(3-)
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
is: SBO:0000247
is: HMDB01201
type: Species
is: CHEBI:58189
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_351c9d74_53e1_43a9_94fe_70f328beb990
boundary condition: true
is: Q16760
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: DGKD
is encoded by: hsa:8527
initial concentration: NaN

metaR NOt
reversible: true
name: NO transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110062#
is: SBO:0000185

metaR CO2tp
product: MODEL1310110062#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: CO2 peroxisomal transport
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_1e6c94c2_26bc_4bb3_aacd_ffdec0e38824
initial concentration: NaN
initial amount: NaN
constant: false
name: DBT
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: P11182
is encoded by: hsa:1629

http://identifiers.org/biomodels.db/MODEL1310110062#_9952ebac_ca99_488a_835d_f7bf1080647a
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:65985
name: AACS
is: Q86V21

metaR GLCter
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: glucose transport, endoplasmic reticulum
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is described by: ECO:0000000
type: Reaction

metaM acgal g
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: N-acetyl-D-galactosamine
is: HMDB00212
is: CHEBI:28037
type: Species
boundary condition: false
constant: false
has only substance units: false

metaR PROSTGE2t2
reactant: MODEL1310110062#
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
reversible: true
type: Reaction
product: MODEL1310110062#
name: prostaglandin uniport
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

metaR r0641
is version of: http://identifiers.org/ec-code/3.1.2.4
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
type: Reaction
is described by: ECO:0000000
product: MODEL1310110062#
modifier: MODEL1310110062#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_07aef1cb_d60d_40fd_8940_e5ce3cb6412b
name: LDHB
is: P07195
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3945

http://identifiers.org/biomodels.db/MODEL1310110062#_73364395_06c2_40b3_a5de_2c81cf6f7237
type: Species
is encoded by: hsa:376497
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: SLC27A1
initial amount: NaN

metaR r2525
product: MODEL1310110062#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#

metaR NDPK4
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP)
type: Reaction
reversible: true
modifier: MODEL1310110062#
is: SBO:0000176

metaR FAOXC13C11m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e5aeb111_b4f9_41c8_9a3c_8009bdc7fe8d
is: SBO:0000252
constant: false
is encoded by: hsa:10164
has only substance units: false
initial concentration: NaN
is: Q8NCG5
name: CHST4
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_34c61b08_7a81_4513_8c9d_b0c9abc41778
initial concentration: NaN
is: O94777
has only substance units: false
is encoded by: hsa:8818
name: DPM2
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_08e849f3_c337_4956_a11f_86a077a029e5
name: _MBOAT5_1_c
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:MBOAT5
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_842399e5_92ed_4a94_8e6f_bf24ab75b051
constant: false
initial amount: NaN
is: Q9BV10
name: ALG12
is encoded by: hsa:79087
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaM HC00900 c
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
has only substance units: false
name: Methylmalonate
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30860
initial amount: NaN

metaM e4p c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
has only substance units: false
is: CHEBI:16897
name: D-Erythrose 4-phosphate
initial amount: NaN
constant: false
is: C00279
is: HMDB01321
initial concentration: 1.0
type: Species

metaM pheacgln e
is: HMDB06344
initial amount: NaN
has only substance units: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: CHEBI:58310
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false

metaM dgdp m
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
is: HMDB00960
initial concentration: 1.0
boundary condition: false
is: CHEBI:58595
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: dGDP(2-)
type: Species

metaR r0642
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_8b056cb4_cb6e_4855_ad0d_335fe67079c0
boundary condition: true
is: SBO:0000252
is encoded by: hsa:686
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: BTD
is: P43251

metaR NDPK3
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
product: MODEL1310110062#
name: nucleoside-diphosphate kinase (ATP:CDP)
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR ST3GAL61g
reversible: false
kinetic law: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (10402.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10206952 NOTES:NJ
reactant: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
product: MODEL1310110062#
name: Type 2 lactosamine alpha-2,3-sialyltransferase

metaM malcoa c
name: Malonyl-CoA
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: C00083
is: CHEBI:57384
constant: false
is: HMDB01175
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: SBO:0000247
boundary condition: false

metaR NDP7ex
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: nucleoside-diphosphatase (UDP), extracellular
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
reactant: MODEL1310110062#

metaM gdp g
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:58189
is: HMDB01201
is: SBO:0000247
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN

metaM dhap c
initial amount: NaN
constant: false
type: Species
is: HMDB01473
name: Dihydroxyacetone phosphate
boundary condition: false
is: C00111
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
is: CHEBI:57642
has only substance units: false
initial concentration: 1.0

metaM pydx e
name: Pyridoxal
is: C00250
is: CHEBI:17310
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01545

metaR NDPK2
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
reversible: true
name: nucleoside-diphosphate kinase (ATP:UDP)
type: Reaction
modifier: MODEL1310110062#

metaM vacc e
is: SBO:0000247
name: trans-vaccenate
constant: false
is: CHEBI:30828
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
initial concentration: 1.0
type: Species

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR SMPD4
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
name: sphingomyelinase
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ

metaM 3decdicoa m
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: 3,7-decadienoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247

metaM thmmp c
initial concentration: 1.0
initial amount: NaN
is: HMDB02666
is: SBO:0000247
is: CHEBI:37575
is: C01081
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
constant: false
type: Species
boundary condition: false
name: Thiamin monophosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_3b4b515b_bead_4011_aedc_79a50d045051
boundary condition: true
name: GLRX
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2745
is: P35754
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_88828dd1_779b_4a52_aae1_5075e5c0f924
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ADCY8
is: Q4F7X0
is encoded by: hsa:114
constant: false
initial concentration: NaN

metaM bilglcur c
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
is: CHEBI:57767
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false

metaR RE1527M
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110062#
name: RE1527
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#

metaR TCYNTtm
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: Thiocyanate transport via diffusion (mitochondrial)
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false

metaM pheacgln c
is: CHEBI:58310
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: HMDB06344
initial concentration: 1.0
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1

metaR NDPK1
is: SBO:0000176
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:GDP)
kinetic law: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110062#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR NAGAlby
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110062#
name: N-acetylgalactosaminidase, beta-
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
is described by: ECO:0000000

metaM oxa c
is: HMDB02329
name: oxalate(2-)
is: SBO:0000247
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM retinal cis 9 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
boundary condition: false
constant: false
name: all-trans-retinal
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:17898
type: Species
is: HMDB01358
initial concentration: 1.0

metaM ddece1crn e
name: dodecenoyl carnitine
is: HMDB00791
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C02838
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C19H35NO4 CHARGE: 0
type: Species

metaM o2 r
name: O2
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:15379
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: SBO:0000247
is: HMDB01377
initial amount: NaN
is: C00007

metaR BPNT
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000269
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.7
type: Reaction
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
kinetic law: MODEL1310110062#
name: 3',5'-bisphosphate nucleotidase

http://identifiers.org/biomodels.db/MODEL1310110062#_d0a38047_ca70_4efa_a727_b852babddcae
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM ksii core2 deg8 l
is: SBO:0000247
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 8
initial concentration: 1.0
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial amount: NaN
is: HMDB00143
type: Species
constant: false
is: CHEBI:12936
has only substance units: false

metaR FAOXC61C4m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM biocyt m
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
has only substance units: false
is: SBO:0000247
is: C05552
initial amount: NaN
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
type: Species
constant: false
boundary condition: false

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaM nrpphrsf c
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial amount: NaN
is: http://identifiers.org/pubchem.compound/123747
initial concentration: 1.0
name: Sulfate derivative of norepinephrine
is: HMDB02062
constant: false

metaR FACOAL240
name: fatty-acid--CoA ligase
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110062#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_78a97d40_c745_433b_8b30_f94ca7694a4d
type: Species
boundary condition: true
is encoded by: hsa:56301
has part: Q9NS82
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6520
has part: P08195
name: SLC7A10:SLC3A2
is: SBO:0000297

metaR PMEVKx
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
product: MODEL1310110062#
name: phosphomevalonate kinase
modifier: MODEL1310110062#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.2

metaM nmn n
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C11H14N2O8P CHARGE: -1 INCHI: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/p-1/t7-,8-,9-,11-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: HMDB00229
name: NMN(-)
is: SBO:0000247
is: CHEBI:14649
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_a2029b53_0c5e_4bd1_a5d4_523febca9b97
constant: false
is encoded by: hsa:AI697028
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AI697028_1_e
has only substance units: false
boundary condition: true

metaM ksii core4 pre10 g
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 10
is: CHEBI:28067
constant: false
has only substance units: false

metaM 3hpcoa m
is: HMDB06807
type: Species
is: CHEBI:58528
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 3-hydroxypropanoyl-CoA(4-)

metaR r2521
fast: false
is: SBO:0000185
name: Utilized transport
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_5ea32212_aa7a_4169_b4c5_01f0abc069b3
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q8N3E9
initial concentration: NaN
constant: false
name: PLCD3
is encoded by: hsa:113026
initial amount: NaN

metaR LNLCCPT2
reactant: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_4c86eb5b_8c5c_4aa2_b22f_d6f3f6090b81
is: B3KXN9
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:84890
has only substance units: false
constant: false
name: ADO

http://identifiers.org/biomodels.db/MODEL1310110062#_a947479e_b121_483c_afb3_f3b18be864b6
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P07101
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:7054
name: TH

http://identifiers.org/biomodels.db/MODEL1310110062#_6ed5f087_f3ca_4402_9c94_e77fc9b1cb77
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:644
name: BLVRA
initial amount: NaN
boundary condition: true
is: P53004

metaM adrncrn m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00062
type: Species
is: SBO:0000247
is: C00318
notes: FORMULA: C29H49NO4 CHARGE: 0
name: Adrenyl carnitine
is: CHEBI:16347
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_f91bdaff_77bf_4e35_838a_06db3fda240f
is encoded by: hsa:3423
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: IDS
type: Species
is: P22304
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_7316b84c_cf78_4882_b7e0_609d801a1c09
constant: false
initial amount: NaN
initial concentration: NaN
is: Q68CJ7
name: UROC1
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:131669

metaM f1a g
is: CHEBI:17151
initial amount: NaN
is: HMDB02917
name: F1alpha
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
has only substance units: false
boundary condition: false
constant: false
type: Species

metaM ha l
initial amount: NaN
name: hyaluronan
is: CHEBI:16336
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518

http://identifiers.org/biomodels.db/MODEL1310110062#_1e9b208f_501f_4efd_973c_28ba3e5829e6
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: VNN2
boundary condition: true
is: O95498
constant: false
is encoded by: hsa:8875

metaR METLEUex
kinetic law: MODEL1310110062#
name: Methionine/Leucine exchange (Met in)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
modifier: MODEL1310110062#
fast: false
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction

metaM 2mb2coa c
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB02054
name: 2-methylcrotonoyl-CoA(4-)
constant: false
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
initial amount: NaN

metaM nrpphrsf e
type: Species
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/123747
boundary condition: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: HMDB02062
initial concentration: 1.0
constant: false
name: Sulfate derivative of norepinephrine
is: SBO:0000247

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM ksi deg6 l
has only substance units: false
is: HMDB00143
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 6
constant: false
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
initial amount: NaN
type: Species

metaR RE3004M
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
reversible: true
name: RE3004
modifier: MODEL1310110062#
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaM fpram c
is: CHEBI:58478
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
is: C04640
has only substance units: false
is: HMDB06211
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_522c4955_187d_47db_a2d5_d77b5f6c099a
type: Species
boundary condition: true
initial amount: NaN
name: QDPR
is: SBO:0000252
initial concentration: NaN
constant: false
is: P09417
is encoded by: hsa:5860
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_474c0c4d_80d0_437f_a28e_a1785d3710d6
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
initial amount: NaN
boundary condition: true
type: Species
is: D3DX95
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_f54cf786_580e_4682_8771_59e02c50c2a0
constant: false
name: ATIC
is encoded by: hsa:471
boundary condition: true
type: Species
has only substance units: false
is: P31939
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR UMPK3n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
name: UMP kinase (UTP),nuclear
is described by: ECO:0000269
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false

metaR UAGDP
type: Reaction
modifier: MODEL1310110062#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.23
reversible: false
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
name: UDP-N-acetylglucosamine diphosphorylase
is: SBO:0000176
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
kinetic law: MODEL1310110062#

metaM 2docohexecoa m
name: 2,7,10,13,16,19-docosahexenoylcoa
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: HMDB06294

http://identifiers.org/biomodels.db/MODEL1310110062#_217b41b3_6239_45d2_9f9f_aeba4c5850ab
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9UBY0
name: SLC9A2
is: SBO:0000252
is encoded by: hsa:6549
boundary condition: true

metaR LEUTAm
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
name: leucine transaminase, mitochondrial
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
type: Reaction

metaM core3 g
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
has only substance units: false
name: Core 3
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16250
boundary condition: false

metaM 4mzym int1 r
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB06927
initial concentration: 1.0
name: 4-Methylzymosterol intermediate 1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_70fc2d1e_2fba_44fb_badb_8b36256a7102
name: PIGQ
is: SBO:0000252
is: B2RAU6
is encoded by: hsa:9091
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR SQLSr
is version of: http://identifiers.org/ec-code/2.5.1.21
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
reversible: false
name: Squalene synthase
type: Reaction
product: MODEL1310110062#
is: SBO:0000176

metaM gdp m
has only substance units: false
is: C00035
is: HMDB01201
type: Species
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_9ca2fbb7_f1ab_44e0_b881_71592e292ebb
initial concentration: NaN
has part: Q9UBK5
name: HCST:PIK3CG
is encoded by: hsa:10870
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:5294
has part: P48736
is: SBO:0000297
constant: false

metaR r2419
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110062#
type: Reaction

metaM o2 x
boundary condition: false
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
constant: false
is: C00007
initial amount: NaN
initial concentration: 1.0
name: O2
is: SBO:0000247
has only substance units: false
is: CHEBI:15379

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR C101CPT1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_5ccd0138_6ad3_4bff_8b68_ceba34482478
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:57194
initial concentration: NaN
name: ATP10A
boundary condition: true
initial amount: NaN
is: O60312

http://identifiers.org/biomodels.db/MODEL1310110062#_ac479162_0241_430c_8e81_bd28c7e7906f
is: Q5JPA4
initial amount: NaN
name: SLCO1C1
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:53919
type: Species
has only substance units: false
boundary condition: true

metaM CE5118 m
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
initial amount: NaN
is: CHEBI:57923
is: SBO:0000247

metaR GLNTHRNaEx
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110062#
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false

metaM gdp n
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58189
name: GDP(3-)
initial concentration: 1.0
type: Species
is: HMDB01201
has only substance units: false
initial amount: NaN

metaR PYAM5POr
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.4.3.5
is: SBO:0000176
type: Reaction
name: pyridoxamine 5'-phosphate oxidase
is described by: ECO:0000269
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT

metaR FAOXC140
modifier: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110062#
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is described by: ECO:0000269
reversible: false

metaM gar c
is: HMDB02022
has only substance units: false
constant: false
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: C03838
initial amount: NaN
is: CHEBI:58457
boundary condition: false

metaR RE3006M
reactant: MODEL1310110062#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110062#
name: RE3006
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110062#

metaM tyr L m
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species
is: SBO:0000247
is: CHEBI:17895
is: HMDB00158
name: L-tyrosine
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaM ddece1crn c
initial concentration: 1.0
is: HMDB03712
is: SBO:0000247
constant: false
notes: FORMULA: C19H35NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
type: Species
name: dodecenoyl carnitine
has only substance units: false

metaR FAOXC18280m
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reversible: false
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110062#
is: SBO:0000176

metaR 4HOXPACDOX NADP
reversible: true
product: MODEL1310110062#
is described by: ECO:0000304
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reactant: MODEL1310110062#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
type: Reaction
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110062#_e19b1326_a8e0_44f2_9b65_101fc1501ece
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: AK5
has only substance units: false
constant: false
is: Q9Y6K8
is encoded by: hsa:26289

metaM tymsf e
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB06409
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
name: Tyramine O-sulfate
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_8cc1a6b3_85c4_46e2_a66d_b22b347af543
has part: Q6NZ59
constant: false
type: Species
is: SBO:0000297
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is encoded by: hsa:522

http://identifiers.org/biomodels.db/MODEL1310110062#_c8a39d4d_bae9_4781_bb41_11ff19b2bf01
type: Species
is: SBO:0000252
constant: false
is: A8K7J7
boundary condition: true
name: HK1
initial amount: NaN
has only substance units: false
is encoded by: hsa:3098
initial concentration: NaN

metaR MI3PP
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
name: myo-inositol 3-phosphatase
reversible: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_69756557_126c_44cb_9983_02a320cd442a
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P08236
type: Species
name: GUSB
is encoded by: hsa:2990
is: SBO:0000252

metaR KYNAKGAT
name: L-Kynurenine:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.7
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_736a6f88_c974_45cd_af7f_baae5f723400
type: Species
is encoded by: hsa:5150
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q13946
initial amount: NaN
name: PDE7A

metaR HSD3A2r
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reversible: true
kinetic law: MODEL1310110062#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110062#
is: SBO:0000176
type: Reaction

metaR HISCAT1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_a80cf121_7a25_49bf_9ce0_bce4d49e8134
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:4967
is: SBO:0000252
name: OGDH
is: Q02218
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_ec785504_7786_4457_9369_12a7c23729c1
is encoded by: hsa:516
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: P05496
boundary condition: true
name: ATP5G1
type: Species
initial concentration: NaN

metaM ppi c
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3
is: CHEBI:0
type: Species
has only substance units: false
initial amount: NaN
is: C00013
is: HMDB00250
name: Diphosphate
boundary condition: false
constant: false
initial concentration: 1.0

metaM orot e
is: CHEBI:30839
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: orotate
is: HMDB00226
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: SBO:0000247
boundary condition: false

metaR DTDPtn
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
name: dTDP nuclear transport
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#

metaM dag hs c
is: CHEBI:18035
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: diglyceride

metaM co e
is: SBO:0000247
has only substance units: false
name: carbon monoxide
initial concentration: 1.0
is: HMDB01361
boundary condition: false
type: Species
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial amount: NaN
constant: false
is: CHEBI:17245

metaR r2313
is: SBO:0000185
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaM betald c
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710
is: HMDB01252
name: betaine aldehyde
constant: false
type: Species
initial amount: NaN

metaM dopa e
initial concentration: 1.0
has only substance units: false
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: SBO:0000247
is: CHEBI:59905
constant: false
type: Species
is: HMDB00073
boundary condition: false
initial amount: NaN

metaR RE2888E
product: MODEL1310110062#
name: RE2888
modifier: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (4025.1) SUBSYSTEM: Purine catabolism EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10600166 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.7
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_eabd6c31_c4f6_4e8a_b143_c1697c181e26
name: HK1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:3098
is: SBO:0000252
boundary condition: true
type: Species
is: Q59FD4

metaR r0733
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110062#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#

metaM hmgcoa m
is: CHEBI:15467
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM Ssq23epx r
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01188
name: (S)-2,3-epoxysqualene
initial amount: NaN
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: CHEBI:15441
is: SBO:0000247
has only substance units: false
type: Species

metaR FACOAL245 1
kinetic law: MODEL1310110062#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
modifier: MODEL1310110062#
product: MODEL1310110062#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110062#
is: SBO:0000176

metaR FAOXC183C163Gm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e422666c_defb_4e19_b7bf_1435efbfc659
name: SLC26A9
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: B3KXK1
is encoded by: hsa:115019

metaR r2312
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#
is: SBO:0000185
fast: false
reactant: MODEL1310110062#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_7031cf14_ad45_43a3_aa7e_9b63f152be41
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PIGN
is: SBO:0000252
is encoded by: hsa:23556
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_e1bb794f_b0c8_43f3_9835_4b42a58a2608
type: Species
initial concentration: NaN
is: Q9UN76
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: SLC6A14
is encoded by: hsa:11254

metaR PROSTGD2t
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110062#
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#

metaM gthox m
is: CHEBI:58297
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB03337
constant: false

metaR r0083
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110062#
reactant: MODEL1310110062#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110062#

metaR r0909
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Transport reaction
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_2a1f3217_6ac3_4950_be33_e2f242f9545d
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9Y2D0
constant: false
name: CA5B
type: Species
has only substance units: false
is encoded by: hsa:11238

http://identifiers.org/biomodels.db/MODEL1310110062#_e61c6640_4bfe_456f_9ca9_1e0fd96f19cf
name: FAH
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2184
is: P16930

http://identifiers.org/biomodels.db/MODEL1310110062#_68b977d0_fb3e_4523_9a16_5bd8dba1cb22
name: NME6
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:10201
is: O75414

metaR r0627
type: Reaction
product: MODEL1310110062#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reactant: MODEL1310110062#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_2dfb2a07_36b8_4a91_91c7_4abc80c627c4
boundary condition: true
is: P07954
constant: false
has only substance units: false
is encoded by: hsa:2271
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: FH

metaR r0732
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110062#
type: Reaction
fast: false
reversible: false

metaR r2315
kinetic law: MODEL1310110062#
reversible: true
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110062#

metaM dopa c
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
initial amount: NaN
is: SBO:0000247
is: CHEBI:59905
boundary condition: false
type: Species
is: HMDB00073
constant: false
initial concentration: 1.0
has only substance units: false

metaM ksi deg18 l
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 18
type: Species
is: HMDB00143
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C146H235N10O127S7 CHARGE: -7

http://identifiers.org/biomodels.db/MODEL1310110062#_b819358e_47f2_41e6_9e32_46b7db788ab8
is: SBO:0000252
type: Species
initial concentration: NaN
is: A5JUY4
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: LPO
is encoded by: hsa:4025

metaR r0908
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: true
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
is described by: ECO:0000000

metaM f1a l
constant: false
is: HMDB02917
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
has only substance units: false
boundary condition: false
is: CHEBI:17151
name: F1alpha
type: Species

metaR AG13T15g
product: MODEL1310110062#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
fast: false
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_aa99a218_e452_4b50_8b36_10e318fa432d
initial amount: NaN
boundary condition: true
constant: false
name: ACAD11
has only substance units: false
is encoded by: hsa:84129
is: SBO:0000252
is: Q709F0
initial concentration: NaN
type: Species

metaR C18OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM dadp m
name: dADP(3-)
initial amount: NaN
is: HMDB01508
has only substance units: false
constant: false
is: CHEBI:57667
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaR r0735
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reversible: true
modifier: MODEL1310110062#
reactant: MODEL1310110062#
fast: false

metaM hxcoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: HMDB06522
type: Species
has only substance units: false
is: SBO:0000247
name: Hexanoyl-CoA (n-C6:0CoA)
boundary condition: false
constant: false

metaR CYTK9n
modifier: MODEL1310110062#
fast: false
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000176
name: cytidylate kinase (CMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110062#

metaR TTDCAtr
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
name: tetradecanoate (transport)
reactant: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
fast: false
product: MODEL1310110062#

metaR r2314
is: SBO:0000185
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_869a6cda_44a9_4210_9f9f_0807d0c6b0c6
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2629
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: GBA
is: B7Z6S9

metaM h x
is: CHEBI:24636
name: proton
is: SBO:0000247
is: C00080
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_71bc6045_4689_4a9c_a905_07d07f4ed51c
name: GMDS
initial amount: NaN
type: Species
is: O60547
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2762
constant: false
has only substance units: false
is: SBO:0000252

metaR FACOAL226
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176

metaR GGT5r
name: Gamma-glutamyltransferase 5
fast: false
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
reactant: MODEL1310110062#

metaR HEXCCOAtx
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110062#
is: SBO:0000185
name: fatty acid intracellular transport
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110062#_14323ff6_c250_4952_aa23_07e2f4067e4c
name: ADCY9
constant: false
is encoded by: hsa:115
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: O60503
is: SBO:0000252

metaM dadp n
is: CHEBI:57667
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
name: dADP(3-)
initial concentration: 1.0
constant: false

metaR r0629
kinetic law: MODEL1310110062#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.4.1
is version of: http://identifiers.org/ec-code/3.6.1.22
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
type: Reaction

metaR r0734
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110062#
is: SBO:0000176
fast: false
reversible: false
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#

metaM msa m
is: CHEBI:33190
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: HMDB11111
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: 3-oxopropanoate

metaR NDP10ex
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110062#
reversible: false
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
kinetic law: MODEL1310110062#
fast: false
name: nucleoside-diphosphatase (IDP), extracellular

metaM pail345p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial concentration: 1.0
is: CHEBI:57836
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_3f3a6b60_707c_4778_ac7e_b9856faecb95
boundary condition: true
name: SLC5A7
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:60482
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9GZV3

metaR FACOAL2251
kinetic law: MODEL1310110062#
fast: false
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
name: fatty-acid--CoA ligase

metaR PROSTGF2t
modifier: MODEL1310110062#
fast: false
type: Reaction
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_ae53d9bf_46db_4992_98a7_99125f181267
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: _AI990637_1_x
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI990637

metaM tettet6coa x
is: http://identifiers.org/pubchem.compound/47205481
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: C16171
is: SBO:0000247
name: tetracosatetraenoyl coenzyme A
initial concentration: 1.0
boundary condition: false
is: HMDB06516

metaR GNDer
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110062#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_5d5ab23a_d0a1_47e1_b9f0_a9bd6eaee5e3
constant: false
boundary condition: true
type: Species
is: Q8NFM4
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ADCY4
initial concentration: NaN
is encoded by: hsa:196883

http://identifiers.org/biomodels.db/MODEL1310110062#_53321825_e5e1_4173_8083_ac86adf22344
initial concentration: NaN
is: P24310
is: SBO:0000252
initial amount: NaN
constant: false
name: COX7A1
boundary condition: true
is encoded by: hsa:1346
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_69ea5f34_5523_4655_856f_3267a75bab78
is: O75874
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:3417
name: IDH1
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaR FACOAL2252
is: SBO:0000176
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
is described by: ECO:0000269
product: MODEL1310110062#
fast: false
reversible: true
name: fatty-acid--CoA ligase

metaR r1396
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
name: EC:2.3.1.21
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_986a5149_cf7e_4856_a9ee_e81c79a43746
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:151531
initial concentration: NaN
is: SBO:0000252
name: UPP2
constant: false
is: O95045
boundary condition: true

metaM ksii core2 deg1 l
is: CHEBI:57737
initial amount: NaN
has only substance units: false
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
boundary condition: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 1
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00868

metaR CITt4 2
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185
reversible: true
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
fast: false
name: citrate transport via sodium symport
is described by: ECO:0000269

metaM thcholstoic m
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
is: HMDB03873
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

metaR RE1517M
product: MODEL1310110062#
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
fast: false
reversible: true

metaR DHFtm
fast: false
reactant: MODEL1310110062#
name: dihydrofolate reversible mitochondrial transport
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110062#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_5da83f0d_dd33_4886_9558_6ac45e6b644a
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: NME7
constant: false
is encoded by: hsa:29922
has only substance units: false

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM ksi pre7 g
initial concentration: 1.0
is: CHEBI:58053
is: C00130
is: SBO:0000247
has only substance units: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2
name: keratan sulfate I biosynthesis, precursor 7
type: Species
is: HMDB00175
constant: false
initial amount: NaN
boundary condition: false

metaR BTNtn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
product: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
type: Reaction
name: Biotin transport, nuclear
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_6efdb2a5_c91b_4927_8326_d44605efe9bd
type: Species
initial concentration: NaN
is encoded by: hsa:AI620219
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: _AI620219_1_c
has only substance units: false

metaM 5tedtricoa m
initial amount: NaN
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
name: 5,8,11-tetradecatrienoylcoa
is: HMDB02288
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM doldp L r
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
has only substance units: false
is: CHEBI:15750
name: Dolichol diphosphate, human liver homolog
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

metaM btn e
name: Biotin
is: C00120
is: CHEBI:3420
constant: false
initial concentration: 1.0
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

metaR r1397
kinetic law: MODEL1310110062#
is: SBO:0000176
reversible: false
type: Reaction
name: carnitine acetyltransferase EC:2.3.1.7
is described by: ECO:0000000
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaM 2mb2coa m
is: HMDB02054
is: CHEBI:57337
has only substance units: false
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial concentration: 1.0
boundary condition: false
name: 2-methylcrotonoyl-CoA(4-)
type: Species
initial amount: NaN
is: SBO:0000247

metaR r2311
fast: false
is: SBO:0000185
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM dag hs e
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
name: diglyceride
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:18035

metaM pppg9 m
name: Protoporphyrinogen IX
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
boundary condition: false
constant: false
is: CHEBI:57307
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01097
initial concentration: 1.0
is: C01079

metaR r0731
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: false
type: Reaction
product: MODEL1310110062#

metaM cs b deg1 l
has only substance units: false
constant: false
is: CHEBI:57455
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
boundary condition: false
initial concentration: 1.0
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
is: HMDB01354
is: SBO:0000247
initial amount: NaN

metaM accoa m
type: Species
name: Acetyl-CoA
initial concentration: 1.0
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00024
has only substance units: false
is: HMDB01206
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_acb2ec72_fdd1_40c0_b5f4_5517a6de7740
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: A7E2E5
initial concentration: NaN
name: PDE3B
is encoded by: hsa:5140
has only substance units: false

metaR PIt8
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000006
type: Reaction
name: phosphate transport in/out via Na+ symporter
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
product: MODEL1310110062#

metaM CE0713 m
is: SBO:0000247
name: 3-oxolinoleoyl-CoA
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
boundary condition: false
has only substance units: false
is: CHEBI:16301
type: Species
is: HMDB02786
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_50444ce3_0ca3_426d_8c20_9650113d5884
is: SBO:0000252
name: ST3GAL3
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: B4DX62
has only substance units: false
is encoded by: hsa:6487

metaR CITt4 4
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
kinetic law: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000006
reversible: true
fast: false
name: citrate transport via sodium symport
product: MODEL1310110062#

metaM ksi pre11 g
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:28067
initial amount: NaN
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 11
boundary condition: false
notes: FORMULA: C129H208N9O101S3X CHARGE: -4

metaR r2310
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaM 3mob e
initial concentration: 1.0
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
boundary condition: false
is: HMDB00019
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
type: Species
constant: false
initial amount: NaN
is: CHEBI:11851

http://identifiers.org/biomodels.db/MODEL1310110062#_9c6d2787_ac78_4d9b_82a7_2bbf547ba0e6
is: SBO:0000252
is encoded by: hsa:AF116616
constant: false
type: Species
name: _AF116616_1_m
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r1684
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000185
reversible: false
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR r0730
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110062#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_97085b65_d00a_48de_a374_4d40df8a88f0
has only substance units: false
name: SLC36A1
initial amount: NaN
boundary condition: true
is: Q1LZ56
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:206358
constant: false
type: Species

metaR FACOAL245 2
fast: false
is described by: ECO:0000269
reversible: true
product: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
name: fatty-acid--CoA ligase
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM btn c
name: Biotin
initial amount: NaN
has only substance units: false
is: HMDB00030
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:3420
is: C00120
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1

metaM hxcoa c
is: SBO:0000247
has only substance units: false
is: HMDB13130
type: Species
initial concentration: 1.0
name: Hexanoyl-CoA (n-C6:0CoA)
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110062#_14359a08_9610_4b0a_bef6_a13204fc962f
name: GGT1
is: P19440
has only substance units: false
is encoded by: hsa:2678
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaR C50CPT1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM 3hddcoa m
is: C05280
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB03952
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
boundary condition: false

metaR COt
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
name: CO transporter via diffusion
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_8c0c781b_d6d4_44f6_bfa9_67c966a2ed28
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:4645
initial concentration: NaN
name: MYO5B
is: Q9H6Y6
type: Species

metaR r2200
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
modifier: MODEL1310110062#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_02b9237f_0c7c_41dd_a9fb_4c20ec333e72
type: Species
initial concentration: NaN
is: P48735
has only substance units: false
name: IDH2
boundary condition: true
initial amount: NaN
is encoded by: hsa:3418
is: SBO:0000252
constant: false

metaM prostge2 c
initial concentration: 1.0
type: Species
constant: false
name: prostaglandin E2(1-)
is: HMDB01220
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:606564

http://identifiers.org/biomodels.db/MODEL1310110062#_8b2f9be4_40bd_4fbc_9c40_76ad05ad1bd3
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:8818
constant: false
is: SBO:0000252
has only substance units: false
name: DPM2

http://identifiers.org/biomodels.db/MODEL1310110062#_c1d93ef6_761b_4f80_ab82_560b2ffe1063
name: HADH
initial amount: NaN
is: SBO:0000252
constant: false
is: Q16836
is encoded by: hsa:3033
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

metaR ACNAMlt
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
name: N-acetylneuraminate transport into lysososme
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
reactant: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000269

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM glcur e
is: CHEBI:15748
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
type: Species
is: HMDB00127
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
name: D-glucuronate

metaR HDDACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR r1466
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
name: EC:2.3.1.86
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000176
reversible: true

metaR NAGLCAly
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
reversible: false
name: N-acetylglucosaminidase, lysosomal
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
kinetic law: MODEL1310110062#
type: Reaction

metaM HC02203 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: prostaglandin-a2
is: SBO:0000247
constant: false
is: CHEBI:27820
initial amount: NaN

metaR CORE2GTg
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
fast: false
modifier: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110062#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: false
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000134
fast: false
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay

metaM HC02216 e
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
is: CHEBI:28922
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR IDOURte
name: L-iduronate transport, extracellular
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000134

metaM 3mob c
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: HMDB00019
is: CHEBI:11851
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaM accoa n
is: SBO:0000247
is: HMDB01206
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
boundary condition: false
is: CHEBI:57288
has only substance units: false
name: acetyl-CoA(4-)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_a66f9f4e_dcc1_484a_ab81_eafb5dd010ae
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6510
is: SBO:0000252
initial concentration: NaN
type: Species
name: SLC1A5
initial amount: NaN
is: Q15758

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
constant: false
name: nLc7Cer
is: CHEBI:26174
initial amount: NaN
is: SBO:0000247

metaM gdp c
has only substance units: false
is: HMDB01201
is: C00035
constant: false
name: GDP
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58189
is: SBO:0000247

metaM ksi pre36 g
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067
constant: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 36
has only substance units: false
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
type: Species
boundary condition: false

metaM CE2705 c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:36781
name: quinonoid dihydrobiopterin
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_3600dec2_e788_4212_9d8d_dead82704809
type: Species
has only substance units: false
is encoded by: hsa:D29675
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: _D29675_1_c
is: SBO:0000252

metaR r1467
product: MODEL1310110062#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110062#
is described by: ECO:0000000
name: Postulated transport reaction
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:

metaM prostge2 e
is: HMDB01220
is: SBO:0000247
name: prostaglandin E2(1-)
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
initial amount: NaN
boundary condition: false

metaR r2202
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110062#
fast: false
type: Reaction
is described by: ECO:0000000

metaR GGLUCT
name: gamma-glutamylcyclotransferase
reactant: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.2.4
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
modifier: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_968b4a36_a3b3_4ab2_89fa_3de66db972e9
name: CA4
is: Q6FHI7
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:762
initial concentration: NaN

metaM glcur c
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00127
constant: false
has only substance units: false
name: D-glucuronate
initial amount: NaN

metaM HC02216 c
has only substance units: false
initial amount: NaN
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: CHEBI:28922
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_07777eee_560c_479b_b1d8_121edad79d28
name: SLC35A1
has only substance units: false
is encoded by: hsa:10559
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P78382
type: Species
initial amount: NaN

metaM HC02203 c
initial amount: NaN
constant: false
is: CHEBI:27820
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
boundary condition: false
name: prostaglandin-a2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_5151ac92_fcc9_4464_a69d_4c72dfacdd5e
initial concentration: NaN
name: TM7SF2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7108
is: O76062
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR FUT16g
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.69
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
name: Galactoside 2-alpha-L-fucosyltransferase 1
modifier: MODEL1310110062#
is described by: ECO:0000269
fast: false

metaR r2201
modifier: MODEL1310110062#
is described by: ECO:0000000
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
is: SBO:0000185

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaM hmgcoa c
constant: false
type: Species
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:15467
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaR FAOXC226C205m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaR ADNCYC
product: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000176
name: adenylate cyclase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
fast: false
is version of: http://identifiers.org/ec-code/4.6.1.1
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_bc36da22_f852_4bd1_b261_43d9fe1c4757
boundary condition: true
name: DGKZ
constant: false
initial amount: NaN
is: B7Z6M3
type: Species
is encoded by: hsa:8525
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM acac e
is: SBO:0000247
name: acetoacetate
is: HMDB00060
initial concentration: 1.0
is: CHEBI:13705
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaR DPCOAtl
kinetic law: MODEL1310110062#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
name: dephospho-CoA transport from lysosome via diffusion

http://identifiers.org/biomodels.db/MODEL1310110062#_2ccee72f_3036_4d87_a742_c4bdef75fd56
constant: false
has only substance units: false
name: MTMR6
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9107
is: Q9Y217
initial concentration: NaN
boundary condition: true

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaR r2317
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
product: MODEL1310110062#

metaM pppg9 c
boundary condition: false
name: Protoporphyrinogen IX
type: Species
initial amount: NaN
is: HMDB01097
initial concentration: 1.0
is: C01079
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57307

http://identifiers.org/biomodels.db/MODEL1310110062#_73a33169_4881_4b17_acc5_f312db2a85bb
type: Species
has only substance units: false
name: SLC17A2
is: O00624
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10246
constant: false
initial amount: NaN

metaR RBFK
is version of: http://identifiers.org/ec-code/2.7.1.26
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
name: riboflavin kinase
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false

metaR G14T19g
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is: SBO:0000176
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110062#

metaM dcacoa m
has only substance units: false
is: C05274
type: Species
constant: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
is: CHEBI:61430
initial concentration: 1.0
boundary condition: false

metaR S6T13g
is: SBO:0000176
modifier: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM citr L m
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00904
boundary condition: false
name: L-citrulline
is: CHEBI:16349
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_fe16139c_48f6_489b_81a8_d4827a34745d
constant: false
is: P55084
initial concentration: NaN
type: Species
name: HADHB
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3032
initial amount: NaN
has only substance units: false

metaM HC02214 e
initial amount: NaN
is: CHEBI:28852
type: Species
constant: false
initial concentration: 1.0
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_f5c6a0f2_f847_4789_9db7_fe5c5630d58f
boundary condition: true
is: SBO:0000252
name: SLC28A3
is: Q9HAS3
type: Species
is encoded by: hsa:64078
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaM btn n
initial concentration: 1.0
name: biotinate
is: CHEBI:57586
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: HMDB00030
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR FAOXC226C227m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_2fc8f284_6ab6_4ad7_805f_e84459d48f00
is: Q56NI9
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ESCO2
initial amount: NaN
is encoded by: hsa:157570
boundary condition: true

metaR r2316
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110062#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
reversible: true

metaM 3thexddcoa c
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
type: Species
boundary condition: false
has only substance units: false
constant: false
name: 3-hydroxy trans7,10-hexadecadienoylcoa
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB02014

metaM taur e
is: CHEBI:3544
initial amount: NaN
has only substance units: false
is: C00245
notes: FORMULA: C2H7NO3S CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: HMDB00251
constant: false
is: SBO:0000247
name: Taurine
type: Species

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR GAL3ST11
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.11
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: Galactosylceramide sulfotransferase
reversible: false
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
fast: false
is: SBO:0000176
modifier: MODEL1310110062#

metaM lanost r
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:16521
boundary condition: false
has only substance units: false
is: HMDB01251
name: lanosterol
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_0b2faf62_21ec_4a29_9d4d_75a39eadd5b9
name: PIGH
initial amount: NaN
is encoded by: hsa:5283
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q14442

metaM acac c
constant: false
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
is: HMDB00060
is: SBO:0000247
is: CHEBI:13705
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

metaR MALTSULtm
kinetic law: MODEL1310110062#
name: Malate:thiosulfate antiport, mitochondrial
fast: false
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110062#
product: MODEL1310110062#

metaR BILIRUBtr
reactant: MODEL1310110062#
is: SBO:0000185
type: Reaction
name: lipid, flip-flop intracellular transport
fast: false
kinetic law: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110062#
is described by: ECO:0000000

metaR r0086
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.3
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
product: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaR r2319
product: MODEL1310110062#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
fast: false

metaM btn m
boundary condition: false
constant: false
name: biotinate
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: HMDB00030
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:57586
initial concentration: 1.0

metaM co c
is: HMDB01361
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
type: Species
name: carbon monoxide
is: CHEBI:17245
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM mgacpail hs r
constant: false
is: CHEBI:7896
is: SBO:0000247
initial amount: NaN
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
boundary condition: false
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: C00249
is: HMDB00220
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_7542a11e_57c4_4e01_a4f7_f655aaeb5043
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA177072
name: _AA177072_1_c
is: SBO:0000252
has only substance units: false

metaR ALADGLYexR
reversible: true
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110062#
is described by: ECO:0000304
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110062#
name: D-alanine/glycine reversible exchange

metaM m7mpdol L r
has only substance units: false
boundary condition: false
initial amount: NaN
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
type: Species
is: CHEBI:37636
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_23039f83_46f2_497c_a57a_f660ceee26ce
name: TDO2
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6999
is: P48775
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

metaM nmn c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:14649
is: C00455
constant: false
name: NMN
is: HMDB00229
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455

metaR r1464
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
name: Active transport

metaR PCHOLP hs
is described by: ECO:0000269
reversible: false
name: choline phosphatase
type: Reaction
fast: false
reactant: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ

metaR CYSSERNaEx
kinetic law: MODEL1310110062#
fast: false
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110062#
reactant: MODEL1310110062#
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reversible: false
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_d03d5ce8_d3a6_4af9_9b25_c9c2cc22f2bf
name: SYNJ1
boundary condition: true
is: C9JFZ1
is encoded by: hsa:8867
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_3f35c6f6_fca3_4cf6_b97e_761d7b5e01f1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:BC005314
name: _BC005314_1_x

http://identifiers.org/biomodels.db/MODEL1310110062#_d67307fa_7ab3_469e_a19f_e0efb4626a66
is encoded by: hsa:377677
name: CA13
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q8N1Q1
constant: false

metaM dgdp c
has only substance units: false
is: C00361
initial amount: NaN
is: HMDB00960
constant: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
is: CHEBI:58595
initial concentration: 1.0
is: SBO:0000247
name: dGDP

metaR DAGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110062#
is: SBO:0000185
name: diacylglycerol transport
product: MODEL1310110062#
fast: false
reversible: true

metaR r2318
is: SBO:0000185
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
product: MODEL1310110062#

metaR r0085
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
modifier: MODEL1310110062#
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110062#
type: Reaction

metaM Rtotal2coa c
is: CHEBI:60377
is: HMDB00095
boundary condition: false
initial amount: NaN
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
has only substance units: false
is: C00055
name: R total 2 coenzyme A
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR HEX10
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
modifier: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
name: hexokinase (D-glucosamine:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110062#
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: false

metaR GCHOLAtx
is described by: ECO:0000000
is: SBO:0000185
name: bile acid intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false

metaR MTHFD
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5
modifier: MODEL1310110062#
type: Reaction

metaM 6dhf e
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
constant: false
name: hexaglutamyl folate (DHF)
boundary condition: false
initial concentration: 1.0
is: HMDB06563
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:0
type: Species
is: C00124
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00143

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR r2538
name: Utilized transport
type: Reaction
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_dd019132_5af5_4ab5_80f5_31d461a6396e
constant: false
has only substance units: false
is: Q96Q11
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:51095
boundary condition: true
name: TRNT1

metaM cit m
is: C00158
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
constant: false
is: CHEBI:16947
name: Citrate
is: SBO:0000247
initial amount: NaN
is: HMDB00094
initial concentration: 1.0
has only substance units: false
type: Species

metaM accoa x
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01206
is: C00024
is: CHEBI:57288
is: SBO:0000247
name: Acetyl-CoA
constant: false
boundary condition: false
initial concentration: 1.0

metaM cmpacna g
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false
is: HMDB01176
is: CHEBI:57812
is: SBO:0000247
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0

metaM dmpp x
is: SBO:0000247
constant: false
type: Species
name: prenyl diphosphate(3-)
initial concentration: 1.0
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: HMDB01120
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57623

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
type: Species
initial amount: NaN
is: CHEBI:61648
boundary condition: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
constant: false

metaR FAOXC183806m
kinetic law: MODEL1310110062#
is described by: ECO:0000269
product: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110062#
fast: false
type: Reaction
name: Beta oxidation of fatty acid

http://identifiers.org/biomodels.db/MODEL1310110062#_1445094b_0159_4175_9aef_94fcd7ade9a8
is encoded by: hsa:10317
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: B3GALT5

http://identifiers.org/biomodels.db/MODEL1310110062#_9fcb462e_8799_4101_acd4_6c2fc4bede23
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P31350
is encoded by: hsa:6241
constant: false
has only substance units: false
name: RRM2

metaM 3octdece1crn c
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB13336
is: SBO:0000247
notes: FORMULA: C25H47NO5 CHARGE: 0
has only substance units: false
name: 3-hydroxy-octadecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110062#_ea6c0cb6_d855_4b79_85c8_9599a663ef5d
is: E2QC23
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:23464
boundary condition: true
initial concentration: NaN
name: GCAT
type: Species

metaM h g
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
is: CHEBI:24636
name: proton
initial concentration: 1.0

metaM Rtotal e
is: HMDB00244
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
initial amount: NaN
name: R total
constant: false
is: C00255
boundary condition: false
is: CHEBI:3554
is: SBO:0000247

metaR SPHS1Ptr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
type: Reaction
fast: false
reactant: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: sphingosine-1-phosphate transport

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c
is: HMDB00143
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
constant: false
is: CHEBI:12936
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1

http://identifiers.org/biomodels.db/MODEL1310110062#_55b3e3fc_4089_431c_936d_5ce148fc2367
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:10195
type: Species
initial concentration: NaN
name: ALG3
is: SBO:0000252

metaM alpro m
type: Species
is: SBO:0000247
is: CHEBI:16882
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
name: S-Aminomethyldihydrolipoylprotein

metaM HC02214 c
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
constant: false
is: CHEBI:28852
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_47068bb1_327d_4532_9144_141538a0eaa5
constant: false
is: P22392
name: NME2
initial concentration: NaN
is encoded by: hsa:4831
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_8f931e63_a236_4a50_acb8_922334bae51e
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:217
name: ALDH2
is: P05091
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

metaM dag hs r
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: diglyceride
constant: false
has only substance units: false
is: CHEBI:18035
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055

http://identifiers.org/biomodels.db/MODEL1310110062#_076a7a56_dd54_46cd_a21f_79493e7f94eb
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has only substance units: false
has part: B2RAU6
is encoded by: hsa:5277
has part: P57054
initial amount: NaN
is encoded by: hsa:5279
initial concentration: NaN
is encoded by: hsa:9091
is encoded by: hsa:51227
boundary condition: true
type: Species
is: SBO:0000297

metaR RE0577C
product: MODEL1310110062#
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
fast: false
name: RE0577
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:

metaM citr L c
name: L-citrulline
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
is: CHEBI:16349
has only substance units: false
constant: false
type: Species
is: HMDB00904

metaR r2420
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
kinetic law: MODEL1310110062#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110062#
fast: false
is: SBO:0000185
reactant: MODEL1310110062#
reversible: true

metaM octe5coa m
type: Species
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
name: 5-octenoylcoa

metaM cs a deg5 l
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
is: CHEBI:15936
notes: FORMULA: C23H36O24S CHARGE: -2
has only substance units: false

metaM hista c
is: CHEBI:58432
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
type: Species
name: histamium
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00870

metaM glcur l
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
is: CHEBI:15748
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
name: D-glucuronate
is: HMDB00127
constant: false
is: SBO:0000247

metaR HSD3A1r
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
product: MODEL1310110062#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110062#
reactant: MODEL1310110062#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
kinetic law: MODEL1310110062#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_4ff61714_6bed_420f_a5fc_30a2cc44a169
is encoded by: hsa:29925
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: GMPPB
type: Species
is: Q9Y5P6
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_2f661230_e86b_409c_b9a0_f66bb8f323d9
is encoded by: hsa:23761
boundary condition: true
is: Q9UG56
type: Species
constant: false
name: PISD
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_c99a923a_66b9_4f6f_ae2b_3c96e190ca7f
is: F5H6D0
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: MOGS
constant: false
is encoded by: hsa:7841
boundary condition: true
is: SBO:0000252

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_3c406934_98cc_4647_b04f_d67e427531d9
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q8NB10
name: PDE1C
constant: false
type: Species
is encoded by: hsa:5137

metaR GLCNACT L
type: Reaction
kinetic law: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110062#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
reversible: false
is: SBO:0000176

metaM lys L x
is: CHEBI:32551
name: L-lysinium(1+)
has only substance units: false
constant: false
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
is: HMDB00182
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_554bda7b_c59e_4d05_bdae_c6ffd7982363
is: SBO:0000252
initial amount: NaN
name: CPT1B
boundary condition: true
type: Species
has only substance units: false
is: E9PCP2
constant: false
is encoded by: hsa:1375
initial concentration: NaN

metaR VALTAm
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
reactant: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
product: MODEL1310110062#
fast: false
name: valine transaminase, mitochondiral

metaR r2534
is described by: ECO:0000000
fast: false
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_36746055_b008_4e7e_aa24_95a157d862bd
initial amount: NaN
has only substance units: false
is: Q9NXB9
name: ELOVL2
constant: false
is encoded by: hsa:54898
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_46a15775_c3e6_440c_9e44_c58e0eac9592
is encoded by: hsa:4905
has part: A0PJH2
is encoded by: hsa:522
is encoded by: hsa:10632
has part: Q6IBB3
is encoded by: hsa:521
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:10476
constant: false
is encoded by: hsa:515
initial concentration: NaN
has part: Q08ET0
has part: P56385
has part: P46459
has part: P05496
has only substance units: false
initial amount: NaN
has part: O75964
type: Species
is encoded by: hsa:516
is: SBO:0000297
is encoded by: hsa:9551
boundary condition: true

metaR HEXDICOAACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaM galacglcgalgbside hs e
boundary condition: false
is: HMDB00143
name: Gal-GlcNAc-Gal globoside
has only substance units: false
is: C00124
type: Species
initial concentration: 1.0
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
is: SBO:0000247
constant: false
is: CHEBI:0
initial amount: NaN

metaR S6TASE22ly
kinetic law: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110062#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110062#
name: galactose-6-sulfate sulfatase, lysosomal

metaM citr L e
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
is: CHEBI:16349
boundary condition: false
initial concentration: 1.0
name: citr_L[e]
type: Species
constant: false
has only substance units: false
is: HMDB00904

metaR VALtec
type: Reaction
modifier: MODEL1310110062#
name: L-valine transport via diffusion (extracellular to cytosol)
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaR r2535
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_80a5bcc7_2b31_41f7_8003_c080e83923bd
has only substance units: false
type: Species
is: SBO:0000252
is: Q9BZX2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7371
initial amount: NaN
constant: false
name: UCK2

metaR LPS2e
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110062#
reversible: false
name: lipase, extracellular
is described by: ECO:0000000
reactant: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
kinetic law: MODEL1310110062#
is: SBO:0000176

metaR CYSASNNaEx
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
is described by: ECO:0000269
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#

metaR TETTET6COAtx
type: Reaction
name: fatty acid intracellular transport
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reversible: true
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is: SBO:0000185

metaR SUCCtp
type: Reaction
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
kinetic law: MODEL1310110062#
name: succinate transporter, peroxisome
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_68529b3f_ebf3_4848_ae28_a2cd72f34243
is: Q9H008
initial amount: NaN
is encoded by: hsa:64077
is: SBO:0000252
name: LHPP
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaR HTDCRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaR r1147
reversible: true
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_fa1bd201_c035_4f3c_9f4e_429507fcf561
name: SLC3A1:SLC7A7
initial concentration: NaN
type: Species
is encoded by: hsa:6519
is encoded by: hsa:9056
is: SBO:0000297
constant: false
initial amount: NaN
has part: Q9UM01
boundary condition: true
has part: Q07837
has only substance units: false

metaM 3hodcoa m
is: HMDB06294
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: (S)-3-Hydroxyoctadecanoyl-CoA
notes: FORMULA: C39H66N7O18P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110062#_8ae52373_8f9e_4a60_8491_3295509fd96e
constant: false
initial amount: NaN
has only substance units: false
is: P30520
type: Species
is encoded by: hsa:159
name: ADSS
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR RNDR4
is: SBO:0000176
fast: false
type: Reaction
reversible: false
product: MODEL1310110062#
name: ribonucleoside-diphosphate reductase (UDP)
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
kinetic law: MODEL1310110062#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110062#

metaM h l
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
constant: false
is: C00080
is: CHEBI:24636

metaR KYNATESYN
is described by: ECO:0000000
reversible: false
product: MODEL1310110062#
is: SBO:0000176
fast: false
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_27a25ffa_a743_49bb_a16f_8db529956794
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: OAT
is encoded by: hsa:4942
type: Species
constant: false
initial concentration: NaN
is: P04181

metaM ivcrn e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00688
has only substance units: false
notes: FORMULA: C12H23NO4 CHARGE: 0
type: Species
name: isovaleryl carnitine
constant: false

metaM galacglcgalgbside hs c
boundary condition: false
initial amount: NaN
name: Gal-GlcNAc-Gal globoside
has only substance units: false
is: CHEBI:58343
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
initial concentration: 1.0
is: HMDB00061
type: Species
is: SBO:0000247
constant: false

metaR HBZOPT10m
is: SBO:0000176
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
kinetic law: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.39
name: Hydroxybenzoate Decaprenyltransferase

metaR r2537
is described by: ECO:0000000
kinetic law: MODEL1310110062#
fast: false
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
reversible: true
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR APOCF
kinetic law: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false
reversible: false
product: MODEL1310110062#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110062#
name: Apocarboxylase formation

metaM h m
constant: false
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
name: proton
boundary condition: false
initial concentration: 1.0
is: CHEBI:24636
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false

metaM CE2705 n
is: CHEBI:15374
initial amount: NaN
boundary condition: false
constant: false
is: HMDB02281
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: quinonoid dihydrobiopterin

metaR MTHFC
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
reversible: true
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.5.1.5
name: methenyltetrahydrofolate cyclohydrolase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_b76bc3fa_02fb_48bc_bbbf_d548501ef54b
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI924226
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: _AI924226_1_m
constant: false

metaR r0630
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.3.1
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110062#
is described by: ECO:0000000
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176

metaR C141CPT1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR S6TASE8ly
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR PIt7
is: SBO:0000185
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
product: MODEL1310110062#
name: phosphate transport in/out via three Na+ symporter
reactant: MODEL1310110062#

metaR r0502
reactant: MODEL1310110062#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
product: MODEL1310110062#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110062#

metaR FAOXC165C164m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_b42b0887_704b_47b7_b595_6ea3764664b4
is encoded by: hsa:10005
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: ACOT8
is: O14734
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR RNDR2
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000254
name: ribonucleoside-diphosphate reductase (GDP)
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reactant: MODEL1310110062#
is: SBO:0000176

metaM 2dr1p c
is: CHEBI:58576
has only substance units: false
constant: false
name: 2-Deoxy-D-ribose 1-phosphate
is: C00672
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
boundary condition: false
is: HMDB01351

metaM so3 m
boundary condition: false
constant: false
is: CHEBI:17137
type: Species
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: SBO:0000247
name: hydrogensulfite
is: HMDB00240
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM vacccoa c
has only substance units: false
is: http://identifiers.org/pubchem.compound/9543677
type: Species
constant: false
name: vaccenyl coenzyme A
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN
initial concentration: 1.0
is: HMDB06521
boundary condition: false
is: SBO:0000247

metaM etfox m
initial concentration: 1.0
is: SBO:0000247
is: HMDB00573
constant: false
type: Species
boundary condition: false
name: Electron transfer flavoprotein oxidized
has only substance units: false
initial amount: NaN
is: CHEBI:30825
notes: FORMULA: R CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110062#_aed50282_faf3_42d9_bec1_fe9806d719b7
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51166
boundary condition: true
name: AADAT
is: Q8N5Z0
constant: false

metaM glyclt x
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: CHEBI:29805
name: glycolate
is: HMDB00115
has only substance units: false
is: SBO:0000247

metaM h n
constant: false
is: CHEBI:24636
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
type: Species
initial amount: NaN
initial concentration: 1.0

metaM cit e
is: HMDB00094
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
name: citrate(3-)
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16947

metaR TETPENT6t
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110062#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaR RNDR1
reversible: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: ribonucleoside-diphosphate reductase (ADP)
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110062#_a6008bb2_755a_46e4_82b9_48d813d63bab
initial concentration: NaN
is encoded by: hsa:137872
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: Q8IWW8
name: ADHFE1

metaR FACOAL160i
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
reversible: false
modifier: MODEL1310110062#
is described by: ECO:0000269
name: C160 fatty acid activation
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_f93ecbf4_3169_41f8_9e8c_aa8414e15777
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ATP5A1
is encoded by: hsa:498
is: P25705
type: Species
is: SBO:0000252

metaR THMPPtm
product: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
name: Thiamine diphosphate transport in via anion antiport, mitochondria
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT

metaR r0504
modifier: MODEL1310110062#
reactant: MODEL1310110062#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is version of: http://identifiers.org/ec-code/2.3.3.10
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
reversible: true
product: MODEL1310110062#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110062#
fast: false

metaM his L c
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:15971
has only substance units: false
initial concentration: 1.0
is: HMDB00177
is: SBO:0000247
name: L-histidine

http://identifiers.org/biomodels.db/MODEL1310110062#_bf11af57_b084_49d5_b21d_50e6b6262b5e
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:145226
initial amount: NaN
is: Q96NR8
name: RDH12
initial concentration: NaN
type: Species
boundary condition: true

metaR GCNTg
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.150
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
fast: false
reversible: false

metaR S4TASE2ly
is version of: http://identifiers.org/ec-code/3.1.6.12
kinetic law: MODEL1310110062#
is described by: ECO:0000000
fast: false
name: N-acetylgalactosamine-4-sulfatase, lysosomal
type: Reaction
reversible: true
product: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_afd96abf_1ec5_4173_aa54_1e586245241e
initial amount: NaN
is encoded by: hsa:5315
initial concentration: NaN
name: PKM2
constant: false
type: Species
is: P14618
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR FAOXC5C3x
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e7f285b8_ad39_41f0_af9a_dd23f7e341ba
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:BE966236
name: _BE966236_1_c
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR ACHEe
product: MODEL1310110062#
name: Acetylcholinesterase
is version of: http://identifiers.org/ec-code/3.1.1.7
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000269
reversible: false
is: SBO:0000176

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

metaR r2532
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000185
product: MODEL1310110062#
is described by: ECO:0000000

metaM mma c
type: Species
initial amount: NaN
is: HMDB00164
constant: false
has only substance units: false
initial concentration: 1.0
name: methylammonium
boundary condition: false
is: CHEBI:59338
notes: FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218
is: SBO:0000247

metaM pail35p hs c
is: SBO:0000247
is: CHEBI:57923
initial amount: NaN
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
boundary condition: false
type: Species
initial concentration: 1.0

metaM CE2434 m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
has only substance units: false
constant: false
boundary condition: false
type: Species
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: CHEBI:57795

metaM acgbgbside hs g
is: CHEBI:17411
constant: false
type: Species
boundary condition: false
is: HMDB00215
name: beta GalNAc globoside
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0

metaR FAOXC16C16OHm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_c163380e_796e_4912_a9d3_fa733bbe964d
is encoded by: hsa:34
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
name: ACADM
is: P11310
is: SBO:0000252
initial amount: NaN

metaR GASNASE2ly
reversible: false
name: glycosylasparaginase, lysosomal
is: SBO:0000176
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110062#

metaR GCHOLAte
type: Reaction
name: bile acid intracellular transport
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false

metaR URATEt
name: urate export from cytosol
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reversible: false
kinetic law: MODEL1310110062#

metaM cmpacna n
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
is: CHEBI:57812
is: SBO:0000247

metaM pan4p c
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:47942
initial concentration: 1.0
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
boundary condition: false
initial amount: NaN
name: Pantetheine 4'-phosphate

metaR RETH
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110062#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false
name: retinyl ester hydrolase
product: MODEL1310110062#
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_a454d87c_aa5b_49b4_90d8_e22cfdc0eb5e
is: SBO:0000252
is encoded by: hsa:5471
boundary condition: true
has only substance units: false
name: PPAT
initial concentration: NaN
initial amount: NaN
is: Q06203
type: Species
constant: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
type: Reaction
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is described by: ECO:0000304
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176

metaR RE3005M
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3005

metaM hgentis c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: HMDB00130
is: CHEBI:16169
name: homogentisate
has only substance units: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544

metaR NACHEXA10ly
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110062#
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110062#
type: Reaction

metaM xylu L c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
constant: false
boundary condition: false
is: CHEBI:17399
is: HMDB00751
type: Species
name: L-xylulose
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_1b81c69a_78bc_4bc6_bee1_23fa51ed2c74
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: _AW299740_1_m
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AW299740
constant: false

metaM galacglcgalgbside hs g
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
type: Species
is: CHEBI:26174
boundary condition: false
constant: false
name: Gal-GlcNAc-Gal globoside
is: SBO:0000247

metaM his L e
is: HMDB00177
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: L-histidine
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:15971
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133

http://identifiers.org/biomodels.db/MODEL1310110062#_b595ab6d_cee7_433c_9d82_2e4ba6bb5df4
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: SULT1A1
boundary condition: true
is encoded by: hsa:6817

metaM pram c
name: 5-Phospho-beta-D-ribosylamine
has only substance units: false
is: SBO:0000247
is: CHEBI:58681
type: Species
is: HMDB01128
initial concentration: 1.0
is: C03090
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090

metaM h r
is: C00080
constant: false
initial concentration: 1.0
is: CHEBI:24636
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: proton
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_6657e1d8_25d0_44f5_ad3b_8e9fb29bf114
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: NUDT12
has only substance units: false
is: Q9BQG2
constant: false
initial concentration: NaN
is encoded by: hsa:83594

http://identifiers.org/biomodels.db/MODEL1310110062#_de66a0bf_0912_4254_b614_32c7d5270a41
boundary condition: true
name: PPAP2B
initial concentration: NaN
is encoded by: hsa:8613
type: Species
has only substance units: false
constant: false
is: O14495
initial amount: NaN
is: SBO:0000252

metaR CHATn
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.6
reversible: true
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110062#

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM 44mctr r
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17813
constant: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
initial amount: NaN
has only substance units: false
is: HMDB01023
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455

metaM din e
constant: false
boundary condition: false
is: C05512
initial concentration: 1.0
initial amount: NaN
name: Deoxyinosine
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
type: Species
is: CHEBI:28997
has only substance units: false
is: HMDB00071
is: SBO:0000247

metaM hista e
is: CHEBI:58432
is: HMDB00870
name: histamium
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
constant: false
initial concentration: 1.0

metaM lys L n
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:32551
constant: false
is: HMDB00182
initial amount: NaN

metaR FATP2t
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
is: SBO:0000185
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport
modifier: MODEL1310110062#
is described by: ECO:0000269

metaM taur x
is: CHEBI:15891
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00251
name: taurine
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
type: Species
initial concentration: 1.0

metaR SPHS1Pte
type: Reaction
product: MODEL1310110062#
name: sphingosine-1-phosphate transport
reactant: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ

metaR FADDPle
reactant: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110062#
name: FAD diphosphatase
kinetic law: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.1

metaM leuktrE4 c
is: HMDB02200
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57462
is: SBO:0000247
boundary condition: false
name: leukotriene E4(1-)
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952

metaR MGCHrm
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18

metaM abt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
is: SBO:0000247
name: L-arabinitol
initial concentration: 1.0
constant: false
is: CHEBI:18403
type: Species
is: HMDB01851
boundary condition: false
initial amount: NaN

metaM peamn c
type: Species
is: CHEBI:225237
name: 2-phenylethanaminium
initial concentration: 1.0
is: HMDB12275
initial amount: NaN
constant: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM dag hs n
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:18035
constant: false
name: diglyceride

http://identifiers.org/biomodels.db/MODEL1310110062#_3de77540_096c_4abe_ba3b_c9fbca75d76f
boundary condition: true
is: B4DPV0
has only substance units: false
type: Species
is encoded by: hsa:5236
constant: false
name: PGM1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_ab641126_7e3e_4d5d_8a69_3d263897749a
is encoded by: hsa:22305
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: _22305_2_c
initial amount: NaN

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM 3mob m
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
is: HMDB00019
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false

metaM acgbgbside hs l
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
has only substance units: false
is: HMDB00215
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17411
is: SBO:0000247
constant: false
name: beta GalNAc globoside
type: Species

metaM lys L m
boundary condition: false
is: HMDB00182
constant: false
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: SBO:0000247
name: L-lysinium(1+)
initial amount: NaN
type: Species
is: CHEBI:32551

metaM cit c
has only substance units: false
is: SBO:0000247
is: HMDB00094
initial concentration: 1.0
is: C00158
type: Species
initial amount: NaN
name: Citrate
is: CHEBI:16947
boundary condition: false
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158

metaM 3hddcoa c
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
constant: false
type: Species
boundary condition: false
is: HMDB00623
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_5b97a798_25a9_4599_b9a2_6f335fdff166
is encoded by: hsa:9856
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: DYLX2
is: SBO:0000252
boundary condition: true
is: F5H123

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM mev R x
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:36464
type: Species
initial amount: NaN
is: HMDB00227
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
name: (R)-mevalonate
initial concentration: 1.0
boundary condition: false

metaM thcholstoic c
is: CHEBI:18402
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
constant: false
is: HMDB03873
has only substance units: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species

metaM hmgcoa x
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
is: HMDB01375

http://identifiers.org/biomodels.db/MODEL1310110062#_4c532fc3_8cf6_4191_addd_86185e9076bf
boundary condition: true
has part: P07327
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:124
is: SBO:0000297
name: ADH1A:ADH1B
has part: P00325
is encoded by: hsa:125

http://identifiers.org/biomodels.db/MODEL1310110062#_5424588d_6395_4445_9071_1d103c56c5ee
is encoded by: hsa:23563
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
name: CHST5
initial amount: NaN
is: Q9GZS9
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_e68aa355_22d0_4d53_8568_28a963e9c5a5
has only substance units: false
name: ALDOA
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:226
boundary condition: true
type: Species
constant: false
is: P04075
initial amount: NaN

metaM din c
name: Deoxyinosine
is: C05512
is: HMDB00071
is: CHEBI:28997
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_f7ac0fee_ee40_48c8_98bd_b2b538826d6e
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q8IZH9
name: GCH1
is encoded by: hsa:2643
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaM leuktrE4 e
initial amount: NaN
name: leukotriene E4(1-)
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57462
has only substance units: false
boundary condition: false
is: HMDB02200

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR UMPK4n
name: UMP kinase (GTP),nuclear
modifier: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110062#

metaM abt e
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
constant: false
name: L-arabinitol
has only substance units: false
initial concentration: 1.0
is: HMDB01851
is: CHEBI:18403
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_a3303617_68c4_42b9_b7c0_8a32a186bc20
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:AI935189
has only substance units: false
constant: false
boundary condition: true
name: _AI935189_1_m
is: SBO:0000252

metaR r1588
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
reversible: true

metaR FAOXC16080m
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaM guln c
name: L-gulonate
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:13115
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247

metaR r2323
is: SBO:0000185
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR SERPT
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.50
type: Reaction
product: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
name: serine C-palmitoyltransferase
kinetic law: MODEL1310110062#

metaR CERT2gt
fast: false
kinetic law: MODEL1310110062#
name: ceramide transport protein
is described by: ECO:0000000
reversible: true
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e5a7fcee_dd81_4501_9d96_bab077a93b8e
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1120
name: CHKB
boundary condition: true
type: Species
constant: false
is: A0PJM6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_beb6a6da_3484_4c54_a9c5_01dc90192516
initial amount: NaN
has part: B3KUV7
has part: Q14442
is encoded by: hsa:8818
is encoded by: hsa:5283
has only substance units: false
has part: Q92535
initial concentration: NaN
is: SBO:0000297
boundary condition: true
is encoded by: hsa:5277
is encoded by: hsa:9091
has part: O94777
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
type: Species
constant: false
has part: Q9BRB3
is encoded by: hsa:5279

metaM lnlccoa c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
is: HMDB01064
constant: false
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial concentration: 1.0
type: Species
has only substance units: false
name: linoleic coenzyme A

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_21bae458_1509_4e22_b349_ba00e8c63afc
is: Q9H0P0
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: NT5C3
is encoded by: hsa:51251
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_3fed6bbc_dea8_4b50_b67c_43ba49767567
initial amount: NaN
name: _AA664770_1_m
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA664770
type: Species
initial concentration: NaN
constant: false

metaM arachcrn m
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB06460
initial concentration: 1.0
name: arachidyl carnitine
type: Species
constant: false
boundary condition: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

metaM udpg r
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58367
is: HMDB00286

metaR r2322
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110062#
reversible: true
is: SBO:0000185
reactant: MODEL1310110062#
type: Reaction

metaM urate e
type: Species
constant: false
is: SBO:0000247
is: HMDB00289
is: CHEBI:17775
initial concentration: 1.0
is: C00366
boundary condition: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_b8867b14_2433_42e1_a917_eda9baa32b34
initial concentration: NaN
boundary condition: true
name: SULT1A3
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6818
initial amount: NaN

metaM g2m8masn r
type: Species
notes: FORMULA: C82H137N2O65X CHARGE: 0
is: C05874
has only substance units: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM HC02210 c
name: prostaglandin-d3
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
constant: false
type: Species
is: CHEBI:34939
initial amount: NaN

metaR r1586
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pan4p e
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: C01134
initial concentration: 1.0
initial amount: NaN
is: CHEBI:47942
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Pantetheine 4'-phosphate
constant: false
is: HMDB01416
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_15a3301d_4068_423f_ad44_d9c932fb7562
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:501
name: ALDH7A1
type: Species
is: E7EPT3
constant: false

metaR TRDR
type: Reaction
modifier: MODEL1310110062#
name: thioredoxin reductase (NADPH)
is described by: ECO:0000269
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.9
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b2bd3d26_316b_443b_9880_bac359edaf12
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:AGPAT7
initial concentration: NaN
has only substance units: false
name: _AGPAT7_1_c

http://identifiers.org/biomodels.db/MODEL1310110062#_3182cc01_4b8a_459f_b2ee_7cce107285b5
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10637
is: O75610
type: Species
constant: false
name: LEFTY1
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM HC00342 m
is: SBO:0000247
initial concentration: 1.0
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: CHEBI:16383
has only substance units: false

metaR r2321
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_fb37eeaf_8e59_43f9_ab21_839aac6a7ab8
constant: false
is: SBO:0000252
initial amount: NaN
name: PRDX1
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5052
is: Q06830

metaM 5mthf c
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01396
boundary condition: false
type: Species
is: C00440
initial amount: NaN
name: 5-Methyltetrahydrofolate
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: CHEBI:3729
is: SBO:0000247

metaR GLCt1r
modifier: MODEL1310110062#
reversible: true
name: glucose transport (uniport)
reactant: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_e5d1c59b_bc10_4e22_b847_efc28ef0417a
is: SBO:0000252
type: Species
is encoded by: hsa:221
boundary condition: true
constant: false
has only substance units: false
is: P43353
name: ALDH3B1
initial amount: NaN
initial concentration: NaN

metaM dhlpro m
is: CHEBI:16194
name: Dihydrolipolprotein
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species

metaR r1587
is: SBO:0000185
reversible: true
product: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_051d7789_7803_4250_97fe_198947cd26bb
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:226
initial amount: NaN
initial concentration: NaN
name: ALDOA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_0e4b24c2_58f0_45ef_b1d4_3614d35b0178
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4056
has only substance units: false
initial concentration: NaN
constant: false
name: LTC4S

metaM 4mop m
boundary condition: false
is: CHEBI:17865
has only substance units: false
initial amount: NaN
is: HMDB00695
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
constant: false
name: 4-methyl-2-oxopentanoate

metaR FAOXC103C102m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaM ha deg1 l
is: SBO:0000247
constant: false
is: CHEBI:16336
name: hyaluronan degradation product 1
boundary condition: false
notes: FORMULA: C22H33N2O16 CHARGE: -1
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_b7621af1_852e_4432_b8a3_56d4c7933ed9
initial amount: NaN
type: Species
has only substance units: false
is: B3KVA3
is encoded by: hsa:112724
initial concentration: NaN
name: RDH13
constant: false
is: SBO:0000252
boundary condition: true

metaR r2320
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185

metaM 3hexdtetcoa m
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: 3,7,10,13-hexadecatetraenoylcoa
is: SBO:0000247
is: HMDB02288

metaR PAIL HStn
is: SBO:0000185
type: Reaction
reversible: true
fast: false
name: phosphatidylinositol nuclear transport (diffusion)
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_3a6e4a64_da59_4a15_a58c_89cb313f5eda
initial amount: NaN
boundary condition: true
is: P07203
name: GPX1
is encoded by: hsa:2876
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaM urate c
is: HMDB00289
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial amount: NaN
is: C00366
has only substance units: false
initial concentration: 1.0
name: Urate
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:17775

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_fucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)1 (Cer)1
is: CHEBI:16094
constant: false
is: HMDB00257
initial concentration: 1.0
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
has only substance units: false

metaR GMPtg
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
kinetic law: MODEL1310110062#
name: GMP transport (Golgi)
is: SBO:0000185
reactant: MODEL1310110062#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269

metaM HC02210 e
type: Species
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:34939
is: SBO:0000247
name: prostaglandin-d3
initial amount: NaN

metaR r0618
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reversible: true
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
type: Reaction
reactant: MODEL1310110062#

metaR r1584
product: MODEL1310110062#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR NDPK8n
is: SBO:0000176
modifier: MODEL1310110062#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
type: Reaction
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
kinetic law: MODEL1310110062#

metaM trdox c
type: Species
is: C00343
constant: false
boundary condition: false
name: Oxidized thioredoxin
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM urea e
name: Urea
is: C00086
boundary condition: false
is: HMDB00294
has only substance units: false
is: CHEBI:16199
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_10b0b96c_6578_46d1_8c74_620d99668755
name: NDUFA4
is encoded by: hsa:4697
constant: false
is: O00483
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR ACNAM9PL2
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.5.1.56
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
is: SBO:0000176
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_6f38062d_1452_432f_a2cf_c970dc119ee0
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: AK2
is: P54819
is encoded by: hsa:204
initial amount: NaN
initial concentration: NaN
constant: false

metaR r2327
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000185
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR FAOXC5C5DCc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_886ba0ad_1489_431a_8988_eb3550150e74
name: BCKDHB
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: P21953
is: SBO:0000252
is encoded by: hsa:594
constant: false
boundary condition: true

metaR RE0827E
reactant: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
product: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
name: RE0827
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#

metaM s2l2n2m2m l
constant: false
initial amount: NaN
is: HMDB00573
is: CHEBI:30825
boundary condition: false
notes: FORMULA: C84H136N6O62 CHARGE: -2
initial concentration: 1.0
name: de-Fuc form of PA6 (w/o peptide linkage)
is: SBO:0000247
has only substance units: false
type: Species

metaR PEt
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
name: phosphatidylethanolamine transport
is described by: ECO:0000000
reversible: true

metaR DHAPtc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of DHAP into cytosol
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
is: SBO:0000185
fast: false
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110062#

metaR r0617
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
type: Reaction
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#

metaM hLkynr c
initial concentration: 1.0
is: SBO:0000247
name: 3-hydroxy-L-kynurenine
is: CHEBI:17380
boundary condition: false
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: HMDB11631
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227

metaR r1585
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_ab914ffc_5123_47d2_928d_666e0d41e4fc
is encoded by: hsa:4719
has only substance units: false
initial amount: NaN
name: NDUFS1
is: P28331
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaM b2coa m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB02009
boundary condition: false
type: Species
name: crotonoyl-CoA(4-)
is: CHEBI:57332

metaR r0093
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
reversible: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_5357ce33_dc61_4ac2_b037_e182f69ba3ea
boundary condition: true
is encoded by: hsa:1633
name: DCK
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: P27707
type: Species

metaR r2326
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_6879ef58_1c61_493f_80dc_a42b0af1dbf7
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:T83654
name: _T83654_1_m
initial concentration: NaN
is: SBO:0000252
type: Species

metaR B3GNT311g
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
kinetic law: MODEL1310110062#
is described by: ECO:0000254
modifier: MODEL1310110062#
type: Reaction

metaM CE4881 e
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: ClNO2 CHARGE: 0 INCHI: InChI=1/ClNO2/c1-4-2-3 EHMN_ABBREVIATION: CE4881
initial concentration: 1.0
boundary condition: false
is: CHEBI:24757
name: nitryl chloride
type: Species
is: SBO:0000247

metaM thbpt4acam c
is: CHEBI:15374
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
type: Species
initial concentration: 1.0
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
initial amount: NaN
is: HMDB02281
constant: false

metaR BACCL
reactant: MODEL1310110062#
type: Reaction
fast: false
product: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is: SBO:0000176
modifier: MODEL1310110062#
name: biotin-[acetyl-CoA-carboxylase] ligase
reversible: false

metaR CYTK8n
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
name: cytidylate kinase (CMP,dATP),nuclear
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM CE0074 e
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: alloxan
notes: FORMULA: C4H2N2O4 CHARGE: 0 INCHI: InChI=1/C4H2N2O4/c7-1-2(8)5-4(10)6-3(1)9/h(H2,5,6,8,9,10) EHMN_ABBREVIATION: CE0074
boundary condition: false
is: HMDB02818
initial amount: NaN
constant: false

metaM HC01410 m
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: CHEBI:28706
name: (2E)-Hexenoyl-CoA

metaR SERTHRNaEx
is described by: ECO:0000269
modifier: MODEL1310110062#
fast: false
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
is: SBO:0000185
reversible: false
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110062#

metaR r0616
product: MODEL1310110062#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110062#

MODEL1310110062
reaction: metaR r2355
reaction: metaR ALATHRNaEx
reaction: metaR TSULt4 3
reaction: metaR r1643
species: metaM nac e
reaction: metaR FAOXC160
species: metaM hdca r
reaction: metaR TMDPP
species: metaM dcdp c
reaction: metaR r2002
reaction: metaR GLUtr
reaction: metaR 34DHXMANDACOX NADP
species: metaM thbpt c
reaction: metaR r0584
species: metaM galthcrm hs g
reaction: metaR METLEUex
species: metaM n2m2nmn l
reaction: metaR r1429
species: metaM h e
species: metaM CE0693 m
species: metaM biocyt n
species: metaM hexdicoa c
species: metaM pi x
species: metaM 4hpro LT c
reaction: metaR RE3346M
species: metaM sucsal m
species: metaM tststerone r
species: metaM g1m8masn r
reaction: metaR FAOXC101C102m
reaction: metaR EX gluala LPAREN e RPAREN
reaction: metaR r2198
reaction: metaR r0655
reaction: metaR CORE6GTg
reaction: metaR EX ksi LPAREN e RPAREN
reaction: metaR KCC2t
species: metaM c6dc e
species: metaM pyr c
reaction: metaR CYSGLYexR
species: metaM 3ivcoa c
reaction: metaR EX udp LPAREN e RPAREN
species: metaM ksi pre9 g
reaction: metaR r0870
species: metaM pa hs g
reaction: metaR DM kdn c
reaction: metaR EX 7dhf LPAREN e RPAREN
species: metaM retinol c
species: metaM c226coa c
species: metaM HC00591 c
reaction: metaR EX 6dhf LPAREN e RPAREN
reaction: metaR r1434
species: metaM mescoa m
reaction: metaR EX tag hs LPAREN e RPAREN
reaction: metaR ELAIDt
species: metaM fmn e
species: metaM HC02187 c
species: metaM 5HPET c
reaction: metaR FTCD
species: metaM ksii core2 deg3 l
species: metaM biocyt c
reaction: metaR LEUKTRF4t
species: metaM pep c
reaction: metaR r0680
reaction: metaR FAOXC3DC
reaction: metaR HACD1m
species: metaM nh4 e
reaction: metaR DHCRD1
species: metaM dtdp e
reaction: metaR MALTSULtm
reaction: metaR HISCAT1
species: metaM dlnlcgcoa m
species: metaM gtp m
reaction: metaR RE3381E
reaction: metaR EX itp LPAREN e RPAREN
reaction: metaR C6DCc
species: metaM chsterol r
reaction: metaR EX malttr LPAREN e RPAREN
species: metaM crvnc e
species: metaM pristcoa c
reaction: metaR BTNDm
reaction: metaR G14T13g

metaR ARACHDt2
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
name: fatty acid transport via diffusion

metaR r2325
reversible: true
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000185

metaR THRGLNexR
fast: false
modifier: MODEL1310110062#
product: MODEL1310110062#
reversible: true
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185

metaR BAAT1x
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
fast: false
name: bile acid Coenzyme A: amino acid N-acyltransferase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
modifier: MODEL1310110062#

metaM c81coa c
is: HMDB03949
constant: false
initial concentration: 1.0
initial amount: NaN
is: C05276
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
name: octenoylcoa
notes: FORMULA: C29H44N7O17P3S CHARGE: -4

metaR r0615
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
is: SBO:0000176
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#

metaR Asn X Ser Thrtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110062#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
type: Reaction
product: MODEL1310110062#
fast: false
is: SBO:0000185
reactant: MODEL1310110062#

metaR r1583
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110062#
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_5086a48c_660e_4a0f_aa1e_ecf0ec2562c3
is: B3KT86
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ADCY3
is encoded by: hsa:109
constant: false
type: Species

metaM retinol cis 11 c
is: CHEBI:16302
is: SBO:0000247
has only substance units: false
is: HMDB06216
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
initial concentration: 1.0
name: 11-cis-retinol

metaM lnlncg r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:32391
name: gamma-linolenate
initial amount: NaN
is: HMDB03073
constant: false

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_8f3e4c32_8212_4e8d_b933_6ddf6002ed20
is encoded by: hsa:NM 013421
boundary condition: true
has only substance units: false
name: _NM_013421_1_e
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaR r2324
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
product: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_4550f829_acdf_46d4_ad8c_083631e64317
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI694761
has only substance units: false
type: Species
name: _AI694761_1_c
boundary condition: true

metaM 3octdece1crn e
is: SBO:0000247
is: HMDB13336
notes: FORMULA: C25H47NO5 CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3-hydroxy-octadecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110062#_07c0b16b_2bcb_4686_822f_3092a335478e
is: SBO:0000252
initial amount: NaN
name: ALDH9A1
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:223
is: P49189

metaM 3odcoa m
is: CHEBI:28528
name: 3-Oxodecanoyl-CoA
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: HMDB03939
is: SBO:0000247
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial concentration: 1.0

metaR r2117
reactant: MODEL1310110062#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_d23a6198_dd6a_4f06_a3f8_1175627d06fb
initial amount: NaN
name: GMPPA
is encoded by: hsa:29926
is: Q96IJ6
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaM dolp L r
is: CHEBI:57683
name: dolichyl phosphate(2-)
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r0614
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110062#

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_3baf985b_e00a_4a87_b59f_418e7a8dd91f
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q5HYI4
is encoded by: hsa:6713
name: SQLE

metaM glyc S e
is: HMDB06372
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:33871
notes: FORMULA: C3H5O4 CHARGE: 0
constant: false
initial amount: NaN
name: (S)-Glycerate
initial concentration: 1.0

metaR DOLPMT L
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.83
fast: false
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
reversible: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Dolichyl-phosphate D-mannosyltransferase (liver)

metaR FUMSO3tm
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
name: Fumarate:sulfite antiport, mitochondrial
is: SBO:0000185
reversible: true

metaR EX decdicrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

metaM ipdp x
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01347
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
name: isopentenyl diphosphate(3-)
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:128769

metaR r2116
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_57d52b33_45d5_43ac_a65f_4bc519b85a50
constant: false
is: SBO:0000252
is: P28330
name: ACADL
has only substance units: false
boundary condition: true
is encoded by: hsa:33
initial concentration: NaN
type: Species
initial amount: NaN

metaM arach e
has only substance units: false
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
type: Species
is: SBO:0000247
initial concentration: 1.0
name: arachidate
is: CHEBI:32360
initial amount: NaN
boundary condition: false
is: HMDB02212

metaM odecoa c
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:3793
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_667034e5_c713_4fb2_ad3e_48f9d92603f9
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: O15121
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8560
name: DEGS1

http://identifiers.org/biomodels.db/MODEL1310110062#_abae431b_7efe_4f09_9ae6_48278179fa12
initial amount: NaN
is encoded by: hsa:2590
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: GALNT2
type: Species
is: Q10471
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c21652de_7ad5_4d71_bd92_6f2f8643a37c
is: SBO:0000252
is encoded by: hsa:1347
boundary condition: true
constant: false
name: COX7A2
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: H0UI06

metaR SO4HCOtex
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
name: sulfate transport via bicarbonate countertransport
type: Reaction
reactant: MODEL1310110062#
reversible: false
product: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110062#

metaR ACGALtlg
name: N-acetyl-galactosamine intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
fast: false
type: Reaction

metaR GBA
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
product: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
fast: false
name: Glucosylceramidase
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.45
is described by: ECO:0000000
is: SBO:0000176

metaR r2329
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110062#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_a466aa09_f21e_4111_87b5_537b928220f7
is: SBO:0000252
boundary condition: true
is: P32929
constant: false
has only substance units: false
name: CTH
is encoded by: hsa:1491
initial concentration: NaN
type: Species
initial amount: NaN

metaR EX c8dc
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for suberyl carnitine
type: Reaction

metaM 6pgc r
constant: false
is: CHEBI:58759
type: Species
initial concentration: 1.0
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 6-phosphonatooxy-D-gluconate
is: HMDB01316

metaR r2115
reactant: MODEL1310110062#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110062#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_9f66e305_f285_4fbf_ab20_9affd64d1f8a
is encoded by: hsa:U37519
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
name: _U37519_1_c

metaM crn x
is: C00318
constant: false
is: CHEBI:16347
name: L-Carnitine
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00062
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR GGH 10FTHF7GLUe
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
kinetic law: MODEL1310110062#
type: Reaction
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110062#
product: MODEL1310110062#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular

metaM glyc S c
type: Species
is: SBO:0000247
is: HMDB06372
constant: false
notes: FORMULA: C3H5O4 CHARGE: 0
has only substance units: false
is: CHEBI:33871
name: (S)-Glycerate
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR SERDGLYexR
modifier: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
name: D-Serine/Glycine reversible exchange
is: SBO:0000185
product: MODEL1310110062#
is described by: ECO:0000304
fast: false
reactant: MODEL1310110062#
type: Reaction

metaR r1177
is: SBO:0000176
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
name: EC:3.1.1.13
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110062#
reversible: false
fast: false
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_a99f2010_db20_45ce_8a54_6783ef4f6789
is: H0YMZ7
initial concentration: NaN
type: Species
name: PDE8A
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:5151

metaM glyclt c
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial concentration: 1.0
type: Species
is: CHEBI:29805
initial amount: NaN
is: SBO:0000247
is: HMDB00115
name: glycolate

metaR PE HSter
reversible: true
is described by: ECO:0000000
name: phosphatidylethanolamine scramblase
is: SBO:0000185
fast: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
product: MODEL1310110062#

metaR DM kdn c
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM kdn(c)
type: Reaction

metaR r2114
product: MODEL1310110062#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
reversible: true

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaR DNDPt39m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: dUTP transport via dGDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is described by: ECO:0000269

metaM ksi pre23 g
is: SBO:0000247
type: Species
is: CHEBI:28067
initial concentration: 1.0
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 23
initial amount: NaN
has only substance units: false

metaR r2328
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
product: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaM pan4p m
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: SBO:0000247
type: Species
is: HMDB01416
initial concentration: 1.0
name: pantetheine 4'-phosphate(2-)
boundary condition: false
has only substance units: false
is: CHEBI:47942
initial amount: NaN

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR 3MOBte
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110062#
name: Transport of 3-methyl-2-oxobutanoate
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110062#
product: MODEL1310110062#

metaR G14T16g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#

metaR 34DHPHEt
is described by: ECO:0000269
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110062#
type: Reaction
name: 3,4-Dihydroxy-L-phenylalanine transport
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD

metaR S6T12g
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#

metaR SBCOAACOTx
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_6d919788_59a6_4538_aefa_fb06ae49fef6
initial concentration: NaN
type: Species
is: P46721
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: SLCO1A2
is encoded by: hsa:6579
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_c918c556_ce7b_46ae_b66f_4e1e9f645d56
has part: Q9NY65
has only substance units: false
is: SBO:0000297
name: EHHADH:ACAA1:ACOX1
initial amount: NaN
is encoded by: hsa:1962
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaM s7p c
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C05382
is: HMDB01068
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57483
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
name: Sedoheptulose 7-phosphate

metaM tetpent3coa c
is: C16167
type: Species
constant: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
boundary condition: false
initial amount: NaN
name: tetracosapentaenoyl coenzyme A, n-3
is: SBO:0000247
initial concentration: 1.0

metaM cala c
is: HMDB00026
constant: false
is: CHEBI:11892
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: N-carbamoyl-beta-alaninate
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_11976b65_194e_4fc8_aa76_791cc0331cb7
boundary condition: true
is encoded by: hsa:376497
is: SBO:0000252
constant: false
is: Q6PCB7
type: Species
has only substance units: false
name: SLC27A1
initial amount: NaN
initial concentration: NaN

metaM ksi deg26 l
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 26
is: HMDB00061
constant: false
has only substance units: false
is: CHEBI:58343
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
type: Species
initial concentration: 1.0

MODEL1310110062#
species: metaM acglcgalgbside hs g
species: metaM HC02204 e
species: metaM galacglcgalgbside hs g
species: metaM 3octdece1crn e
species: metaM ribflv c
species: metaM tddedicoa m
species: metaM ser L e
species: metaM ocdcea r
species: metaM m4mpdol L r
multipler: 2.77777777777778E-4
species: metaM met L e
species: metaM 3hdeccoa m
species: metaM pyr e
species: metaM pglyc hs c
species: metaM acgam c
species: metaM h2o e
species: metaM asp D c
species: metaM 4nphsf c
species: metaM 3decdicoa m
species: metaM ha l
species: metaM tetdece1crn e
species: metaM 2dp6mep m
species: metaM 2mb2coa m
species: metaM mi14p n
species: metaM 42A3HP24DB c
species: metaM pyr c
species: metaM lneldccrn c
species: metaM ksi deg35 l
species: metaM ksi pre5 g
species: metaM csn c
species: metaM 5aop c
species: metaM 4mlacac c
species: metaM no2 e
species: metaM CE2418 m
species: metaM xan c
species: metaM core3 g
species: metaM galgalgalthcrm hs c
species: metaM 3mop c
species: metaM arg L e
species: metaM dgsn c
species: metaM Lpipecol x
species: metaM ksi l
species: metaM frdp r
name: PIK3CB:PIK3R1
species: metaM CE5120 m
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
species: metaM tsul m
species: metaM cspg b e
species: metaM ksi pre34 g
species: metaM lgnc c
species: metaM strdnc e
species: metaM ahdt e
species: metaM CE5854 e
species: metaM cs e deg3 l
species: metaM thcrm hs g
species: metaM 3ddcrn e
species: metaM o2s e
species: metaM ksi deg30 l
species: metaM 3otdcoa m
species: metaM ksi deg14 l
species: metaM gal e
species: metaM acetone e
species: metaM HC01397 m
species: metaM nad c
species: metaM 10fthf6glu e
species: metaM arachcoa m
scale: -3
species: metaM chlstol r
species: metaM taur c
species: metaM leuktrD4 e
species: metaM o2 c
species: metaM ethamp r
species: metaM 2mb2coa c
species: metaM malthx e
species: metaM HC02208 e
species: metaM ptdcacoa c
species: metaM 2mop m
species: metaM anth c
species: metaM sphs1p c
species: metaM acgal l

metaM sph1p e
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: SBO:0000247
initial amount: NaN
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: HMDB01383
initial concentration: 1.0
has only substance units: false
is: CHEBI:57939
type: Species

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR CERT1rt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
fast: false
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110062#
name: ceramide transport protein
product: MODEL1310110062#
reversible: true

metaM trdox m
initial amount: NaN
is: CHEBI:18191
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_03268fbd_680f_444b_a02b_ec40827d5a8d
type: Species
boundary condition: true
is encoded by: hsa:9091
has only substance units: false
constant: false
is: Q9BRB3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PIGQ

metaM ca2 e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
has only substance units: false
name: calcium(2+)
type: Species
initial amount: NaN
is: HMDB00464
is: CHEBI:29108
constant: false

metaR r2119
kinetic law: MODEL1310110062#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110062#
reversible: true
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185

metaM galgalthcrm hs g
initial concentration: 1.0
name: Gal-Gal-Gal-Gal-Glc-Cer
notes: FORMULA: C48H86NO27FULLRCO CHARGE: 0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:26174
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_023f8e52_1629_40f2_8e3c_784226136a38
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:7389
initial concentration: NaN
constant: false
initial amount: NaN
name: UROD
is: P06132

http://identifiers.org/biomodels.db/MODEL1310110062#_c5a11e2e_7cbb_4f13_9bc1_e427c227c86f
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: P21399
is encoded by: hsa:48
initial amount: NaN
name: ACO1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_d9d941d9_dd26_4dba_9536_6d55931596ba
constant: false
name: TPH1
has only substance units: false
is encoded by: hsa:7166
is: P17752
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_576eec3c_8324_445b_be0b_a00b99733c87
constant: false
initial amount: NaN
is encoded by: hsa:8528
is: SBO:0000252
name: DDO
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
kinetic law: MODEL1310110062#
name: blood group intracellular transport
product: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
is described by: ECO:0000000
reversible: true

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_117b29a9_5a03_45a0_9383_6b38980edc46
is: G3XA95
is: SBO:0000252
initial concentration: NaN
constant: false
name: PPAP2A
is encoded by: hsa:8611
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
reversible: true
reactant: MODEL1310110062#
fast: false
name: blood group intracellular transport
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ

http://identifiers.org/biomodels.db/MODEL1310110062#_05fe12a2_5f4d_47f5_a474_2f7a70cd1915
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P00390
is encoded by: hsa:2936
initial amount: NaN
name: GSR
type: Species
boundary condition: true
constant: false

metaR r2118
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110062#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110062#
modifier: MODEL1310110062#

metaM ppcoa c
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00100
has only substance units: false
initial concentration: 1.0
type: Species
name: Propanoyl-CoA

metaM gum e
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
is: http://identifiers.org/pubchem.compound/93131
name: gums
has only substance units: false
type: Species

metaR RE0702E
modifier: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.7
name: RE0702
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (4025.1) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.4 Confidence Level: 0 AUTHORS: PMID:11013238,PMID:9665099 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#
fast: false
type: Reaction

metaM sph1p c
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: CHEBI:57939
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01383
boundary condition: false

metaR SGPL12r
is version of: http://identifiers.org/ec-code/4.1.2.27
kinetic law: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
type: Reaction
name: Sphingosine-1-phosphate lyase
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ

http://identifiers.org/biomodels.db/MODEL1310110062#_2737278a_b050_42e9_a200_ae39ec0c4ef6
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51227
initial amount: NaN
name: PIGP
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_fe7d3fdd_e5ac_4f06_9f2e_38f707932696
name: CHAT
is: Q6LEN5
is: SBO:0000252
is encoded by: hsa:1103
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_e3912dd9_3bf6_47bd_9329_9e44f0736203
name: GPX2
type: Species
initial amount: NaN
constant: false
is: P18283
is encoded by: hsa:2877
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM grdp x
name: geranyl diphosphate(3-)
type: Species
constant: false
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01285
initial concentration: 1.0
boundary condition: false
is: CHEBI:58057

metaR UPPDC1
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
is described by: ECO:0000269
type: Reaction
reversible: false
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
is version of: http://identifiers.org/ec-code/4.1.1.37
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_eb96a268_feac_43f4_bf1f_3169d36652c4
is: SBO:0000252
type: Species
boundary condition: true
name: COX6A1
initial amount: NaN
is encoded by: hsa:1337
is: P12074
initial concentration: NaN
constant: false
has only substance units: false

metaR GCC2cm
product: MODEL1310110062#
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
type: Reaction
modifier: MODEL1310110062#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_fbebe822_c3a8_4cbf_8c76_c9becc9f12ed
is encoded by: hsa:224
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: P51648
name: ALDH3A2
initial amount: NaN

metaM ump n
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00288
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: UMP(2-)
constant: false

metaM xol27oh r
constant: false
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:17703
name: 26-hydroxycholesterol
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
initial amount: NaN
is: SBO:0000247

metaM mn l
constant: false
is: HMDB06535
is: SBO:0000247
initial concentration: 1.0
type: Species
name: beta-1,4-mannose-N-acetylglucosamine
has only substance units: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
boundary condition: false
initial amount: NaN

metaM 34hpp c
is: CHEBI:36242
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00707

metaR MEVK1x
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.36
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
is described by: ECO:0000134
name: mevalonate kinase (atp)
reactant: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_5e837fb1_8f34_4e76_8c8a_f446dd28ad6b
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51268
type: Species
initial amount: NaN
constant: false
is: Q9P0Z9
name: PIPOX

http://identifiers.org/biomodels.db/MODEL1310110062#_f3b97289_3723_4338_9eda_a5c838420e41
initial amount: NaN
name: CHAT
has only substance units: false
is: Q6LEN5
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:1103
is: SBO:0000252

metaR ALDD2y
product: MODEL1310110062#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
fast: false
kinetic law: MODEL1310110062#

metaR LPS3e
is described by: ECO:0000000
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: lipase, extracellular
is: SBO:0000176
modifier: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.3
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ

metaM 10fthf c
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: HMDB00972
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
is: C00234
is: SBO:0000247
initial amount: NaN
is: CHEBI:57454
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_89d4aa9d_e876_4a7a_bd91_003e87812e3b
is encoded by: hsa:R06874
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: _R06874_1_r
is: SBO:0000252
constant: false
initial concentration: NaN

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR PNTOte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of (R)-Pantothenate
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
type: Reaction
reversible: true
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110062#_95ef3b98_d8ee_4acc_a31e_54d63109295b
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2194
is: SBO:0000252
has only substance units: false
name: FASN
is: P49327
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_04b4f5ed_57bd_4b4f_bfc3_5b2775864c55
has only substance units: false
is: SBO:0000297
name: ATP1A3:ATP1B1
has part: A3KLL5
constant: false
initial concentration: NaN
is encoded by: hsa:481
type: Species
has part: B7Z2T0
boundary condition: true
initial amount: NaN
is encoded by: hsa:478

metaR NACHEX8ly
reactant: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false

metaR ALDD2x
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
kinetic law: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NAD)
type: Reaction
reversible: false
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_c1664a43_7970_4b89_9e73_e309238ec6c8
boundary condition: true
is encoded by: hsa:79053
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: ALG8
constant: false
initial amount: NaN

metaR MTHFD2m
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is: SBO:0000176
modifier: MODEL1310110062#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
kinetic law: MODEL1310110062#

metaR PPCOACm
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.4.1.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
reversible: false
fast: false
name: Propionyl-CoA carboxylase, mitochondrial
is: SBO:0000176
type: Reaction

metaM 3docopencoa m
name: 3,7,10,13,16-docosapentenoylcoa
is: SBO:0000247
is: HMDB06294
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR NDP7g
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
name: nucleoside-diphosphatase (UDP), Golgi apparatus
is described by: ECO:0000269
kinetic law: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
fast: false
product: MODEL1310110062#

metaR RE3421R
reactant: MODEL1310110062#
name: RE3421
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
fast: false
type: Reaction
product: MODEL1310110062#

metaM 4abutn m
is: SBO:0000247
initial amount: NaN
constant: false
name: 4-ammoniobutanal
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
type: Species
has only substance units: false
is: CHEBI:58264
initial concentration: 1.0

metaM lnlncg e
is: CHEBI:32391
type: Species
name: gamma-linolenate
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB03073
boundary condition: false
initial amount: NaN

metaR Htr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: H transporter, endoplasmic reticulum
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM damp c
constant: false
name: dAMP(2-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: SBO:0000247
is: HMDB00905
has only substance units: false
type: Species
is: CHEBI:58245
boundary condition: false

metaR RE2660C
name: RE2660
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_833ac750_01ca_4b8f_99cd_32cdd9b8a88a
type: Species
name: NAGK
has only substance units: false
constant: false
is encoded by: hsa:55577
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q9UJ70
is: SBO:0000252

metaR AATAi
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.7
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110062#
name: 2-aminoadipate transaminase, irreversible
is: SBO:0000176

metaR S23T2g
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
reversible: false
reactant: MODEL1310110062#

metaM 5eipencoa m
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB06294
name: 5,8,11,14,17-eicosapentenoylcoa
boundary condition: false
type: Species

metaR OMHPALTD
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_399228ca_78e5_4e73_9bd0_456d680febe9
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:27068
type: Species
has only substance units: false
name: PPA2
constant: false

metaM ump r
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00288
type: Species
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
name: UMP
is: SBO:0000247
boundary condition: false

metaR PI45P3K
is: SBO:0000176
product: MODEL1310110062#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
is described by: ECO:0000000
modifier: MODEL1310110062#

metaM CE5161 r
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57923

metaR r2112
reactant: MODEL1310110062#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110062#
reversible: true
product: MODEL1310110062#

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaM xol27oh m
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB02103
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
name: 26-hydroxycholesterol
type: Species
constant: false
is: CHEBI:17703

metaR FAOXC123C102m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaM HC00342 c
initial concentration: 1.0
name: cis-aconitate(3-)
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
is: CHEBI:16383
has only substance units: false

metaR ARACHt
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110062#
reversible: true

metaR r2113
is: SBO:0000185
reactant: MODEL1310110062#
reversible: true
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#

metaM gthrd e
constant: false
name: glutathionate(1-)
initial amount: NaN
is: CHEBI:57925
is: HMDB00125
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247

metaM lnlncg c
is: CHEBI:32391
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
name: gamma-linolenate
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB03073

metaR SUCOASm
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#
name: Succinate--CoA ligase (ADP-forming)
fast: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
is version of: http://identifiers.org/ec-code/6.2.1.5

metaM nicrnt c
name: Nicotinate D-ribonucleotide
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: SBO:0000247
is: CHEBI:57502
has only substance units: false
constant: false
is: HMDB01132
is: C01185
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_f21d0e4a_7501_4b62_8fdd_855cdfdab697
name: INPP5B
type: Species
constant: false
is: P32019
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3633

http://identifiers.org/biomodels.db/MODEL1310110062#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_482098bd_0fbd_471a_b262_9f4d7050af06
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: Q9Y2C5
initial concentration: NaN
is encoded by: hsa:10050
name: SLC17A4

metaM m8masn r
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
is: C05876
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C70H117N2O55X CHARGE: 0
constant: false

metaM Lcystin c
is: SBO:0000247
name: L-cystine
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
initial amount: NaN
is: CHEBI:16283
is: HMDB00192
constant: false

metaR HPDCACRNCPT2
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
name: heptadecanoate transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reactant: MODEL1310110062#
reversible: false

metaR r2110
kinetic law: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_fab317ed_68fe_4159_898f_31fa50384a34
is: Q92685
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:10195
initial concentration: NaN
boundary condition: true
name: ALG3

metaM ksi deg15 l
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 15
initial amount: NaN
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
is: SBO:0000247
type: Species
has only substance units: false

metaR PAIL4P HStn
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000

metaM retn c
boundary condition: false
initial amount: NaN
name: all-trans-retinoate
constant: false
initial concentration: 1.0
is: HMDB01852
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
type: Species
has only substance units: false

metaR FAOXC184C164m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR CYTDK1
type: Reaction
name: ATPcytidine 5-phosphotransferase
modifier: MODEL1310110062#
product: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
is described by: ECO:0000254
fast: false
reactant: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48

http://identifiers.org/biomodels.db/MODEL1310110062#_5731d35c_cc20_4d77_b407_33875b03198e
constant: false
initial concentration: NaN
is: Q15274
is encoded by: hsa:23475
initial amount: NaN
name: QPRT
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR PGLYCt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
product: MODEL1310110062#
is: SBO:0000185
name: phosphatidylglycerol transport
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
fast: false

metaM pail hs c
is: SBO:0000247
initial amount: NaN
is: CHEBI:57880
boundary condition: false
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)

http://identifiers.org/biomodels.db/MODEL1310110062#_e78ebb58_b76d_47a4_abcc_96831eca6e0d
constant: false
is: SBO:0000252
is encoded by: hsa:10606
initial amount: NaN
is: P22234
type: Species
initial concentration: NaN
boundary condition: true
name: PAICS
has only substance units: false

metaM urcan c
is: SBO:0000247
is: HMDB00301
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
type: Species
constant: false
initial concentration: 1.0
name: Urocanate
is: CHEBI:17771
is: C00785

metaR 5MTAte
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
name: Transport of 5-S-methyl-5-thioadenosine
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR EX gumtchol LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-taurocholic acid complex
type: Reaction

metaM 10fthf e
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00972
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
initial amount: NaN
name: 10-formyltetrahydrofolate(2-)
has only substance units: false
initial concentration: 1.0

metaR FAOXC141C121m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaR HPDCACRNCPT1
name: carnitine fatty-acyl transferase
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110062#
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110062#

metaR Q10H2e
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reactant: MODEL1310110062#
fast: false
name: transport of ubiquinol into lymph
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000134
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_db53f80c_a740_4662_8c1f_3fc9ec2a98e0
constant: false
name: _AW277253_1_c
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AW277253
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r2111
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false

metaR G14T3g
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_48dab0c3_cd75_43e6_a723_54896c66b1f4
boundary condition: true
initial concentration: NaN
constant: false
is: Q8N3T1
type: Species
initial amount: NaN
name: GALNTL2
has only substance units: false
is encoded by: hsa:117248
is: SBO:0000252

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_c1f2df5a_91d1_4dd4_949a_08d3c6b0cceb
initial amount: NaN
name: GMPPA
is encoded by: hsa:29926
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR MAL Ltx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
type: Reaction
fast: false
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: Transport reaction for malate
reversible: true
reactant: MODEL1310110062#

metaM ump e
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: UMP(2-)
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
is: SBO:0000247
is: CHEBI:57865
initial amount: NaN

metaM fuc1p L c
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: SBO:0000247
is: CHEBI:28319
is: HMDB01265
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: L-Fucose 1-phosphate
constant: false

metaR ACGAMPM
reversible: true
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/5.4.2.3
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000176
name: phosphoacetylglucosamine mutase
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD

metaR r1581
product: MODEL1310110062#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
type: Reaction

metaM ksi deg20 l
name: keratan sulfate I, degradation product 20
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
constant: false
is: CHEBI:12936

metaR ACGALtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reactant: MODEL1310110062#
name: N-acetyl-galactosamine lysosomal efflux
product: MODEL1310110062#
type: Reaction
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110062#
is described by: ECO:0000000

metaM retn e
boundary condition: false
type: Species
has only substance units: false
is: HMDB01852
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:35291
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate

metaR GLYSNAT5tc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_70560059_befa_4943_9b90_87bb2b62df47
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: A8K5Z0
initial amount: NaN
type: Species
is encoded by: hsa:8703
name: B4GALT3

metaM n2m2nm l
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:30825
has only substance units: false
boundary condition: false
is: HMDB00573
name: n2m2nmasn (w/o peptide linkage)
notes: FORMULA: C58H97N5O41 CHARGE: 0

metaM thbpt4acam n
type: Species
is: CHEBI:15374
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
boundary condition: false
is: HMDB02281
has only substance units: false

metaM C05279 m
is: CHEBI:28387
has only substance units: false
is: HMDB11123
is: SBO:0000247
type: Species
name: trans,cis-Lauro-2,6-dienoyl-CoA
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
initial amount: NaN

metaM xan c
initial amount: NaN
is: C00385
type: Species
is: HMDB00292
has only substance units: false
name: Xanthine
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: CHEBI:17712
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r1580
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
product: MODEL1310110062#
reversible: true

metaR NADtru
fast: false
is: SBO:0000185
name: NAD transporter, endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000

metaR CBR2
name: Carbonyl reductase [NADPH] 1
fast: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.189
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_16ad2964_79e2_4088_8a7c_6f0c76444620
has only substance units: false
is: P24752
is encoded by: hsa:38
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ACAT1

metaM 4nphsf e
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
name: 4-Nitrophenyl sulfate
initial amount: NaN
is: CHEBI:35422
is: HMDB06492
type: Species
initial concentration: 1.0

metaM HC01444 e
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
initial concentration: 1.0
name: Galactosylglycerol
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:15754

metaM 4abutn c
is: CHEBI:58264
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
name: 4-Aminobutanal
type: Species
is: C00555
is: SBO:0000247
initial amount: NaN
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaR UDPGLCter
type: Reaction
kinetic law: MODEL1310110062#
fast: false
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

metaM arachcrn c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: HMDB06460
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: arachidyl carnitine
boundary condition: false

metaR FACOAL224
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#

metaM ump c
is: C00105
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
has only substance units: false
name: UMP
constant: false
type: Species
boundary condition: false
is: HMDB00288

http://identifiers.org/biomodels.db/MODEL1310110062#_b8c5072d_da14_49ca_9268_e9e3b8ead79d
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: P23786
name: CPT2
is encoded by: hsa:1376
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR B3GNT310g
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000254
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_59a22ab9_23d9_46c8_9cee_09155a2330d3
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: B7Z6M3
constant: false
is encoded by: hsa:8525
type: Species
has only substance units: false
name: DGKZ

http://identifiers.org/biomodels.db/MODEL1310110062#_7d273e31_68c4_451b_999d_120b647c746c
is: P49189
type: Species
boundary condition: true
is encoded by: hsa:223
constant: false
has only substance units: false
initial concentration: NaN
name: ALDH9A1
is: SBO:0000252
initial amount: NaN

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM gthrd c
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
is: CHEBI:57925
is: C00051
name: Reduced glutathione
has only substance units: false
is: HMDB00125
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_3f75e35e_8b09_432a_b13f_5e546a1066cd
is: SBO:0000252
is encoded by: hsa:11046
constant: false
has only substance units: false
initial concentration: NaN
is: Q76EJ3
type: Species
initial amount: NaN
name: SLC35D2
boundary condition: true

metaM sebcoa c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: SBO:0000247
name: sebacoylcoa
is: HMDB13325
has only substance units: false
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_f0d93a72_2486_48c3_9755_355fefc4db2c
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1629
is: P11182
initial amount: NaN
name: DBT

metaR NDPK9n
is: SBO:0000176
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
fast: false
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110062#_703cf7b5_6467_4835_b577_6710a1162784
initial concentration: NaN
has only substance units: false
constant: false
name: COX3
is: SBO:0000252
type: Species
is encoded by: hsa:4514
is: P00414
boundary condition: true
initial amount: NaN

metaM accoa c
initial amount: NaN
type: Species
name: Acetyl-CoA
initial concentration: 1.0
is: SBO:0000247
is: C00024
boundary condition: false
constant: false
is: CHEBI:57288
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false

metaR 41R2A1H12BOOX
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
reversible: false
modifier: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

metaR ABO7g
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.37
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
type: Reaction
product: MODEL1310110062#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

metaM 4abutn e
has only substance units: false
is: HMDB01080
initial concentration: 1.0
constant: false
is: CHEBI:58264
initial amount: NaN
name: 4-ammoniobutanal
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
type: Species
is: SBO:0000247

metaM 4nphsf c
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
name: 4-Nitrophenyl sulfate
is: SBO:0000247
initial amount: NaN
is: CHEBI:35422
initial concentration: 1.0
is: HMDB06492
type: Species

metaR DPMVDx
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
modifier: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: diphosphomevalonate decarboxylase
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/4.1.1.33
fast: false

metaM lnlncg l
name: gamma-linolenate
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: HMDB03073
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:32391
has only substance units: false

metaM ipdp c
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
type: Species
name: Isopentenyl diphosphate
is: CHEBI:128769
is: SBO:0000247
is: HMDB01347
initial concentration: 1.0
constant: false
is: C00129
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_477788ca_5b73_4869_a756_0c1206ae768c
is: SBO:0000252
is: B7Z3U6
constant: false
type: Species
boundary condition: true
is encoded by: hsa:476
has only substance units: false
initial concentration: NaN
name: ATP1A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_72fa652f_6bee_4c07_a0ad_feeadc491192
is: SBO:0000252
name: B3GALT5
type: Species
is encoded by: hsa:10317
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaM 4mop c
is: CHEBI:17865
is: SBO:0000247
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: 4-methyl-2-oxopentanoate
constant: false
boundary condition: false

metaR r0774
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
reactant: MODEL1310110062#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_3ae45be5_892c_4c4c_85cb_c7e76cd30d72
has only substance units: false
has part: Q6FIH7
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
constant: false
initial concentration: NaN
is encoded by: hsa:516
boundary condition: true
type: Species
is: SBO:0000297

metaR NCKt
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
name: Na+/Ca2+-K+ exchange
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_699e1fb0_b3cc_47e8_9f74_b30af0042c90
has only substance units: false
name: PIK3CA
is encoded by: hsa:5290
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P42336
constant: false
type: Species
boundary condition: true

metaM 5mthf e
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: 5-Methyltetrahydrofolate
is: C00440
is: HMDB01396
is: CHEBI:3729

metaR FAOXC160
is: SBO:0000176
reactant: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
name: Beta oxidation of long chain fatty acid
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaM m8masn g
is: C05876
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0

metaR Htg
product: MODEL1310110062#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: proton diffusion (Golgi)
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_403ac28f_617a_4678_8a37_f59084e0aaa8
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q38G75
initial concentration: NaN
type: Species
name: GALE
constant: false
is encoded by: hsa:2582

metaR RE3241R
name: RE3241
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
reversible: false
fast: false
product: MODEL1310110062#

metaR RE2660N
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
name: RE2660
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:

metaM ddsmsterol r
is: HMDB03896
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:27910
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
initial concentration: 1.0
constant: false
name: 7-dehydrodesmosterol
has only substance units: false

metaM 34hpp e
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial amount: NaN
boundary condition: false
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_d78ec5ea_38ba_4dab_a878_72d8f1dd3f35
is: Q9HCR9
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:50940
boundary condition: true
name: PDE11A
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM ump g
has only substance units: false
initial concentration: 1.0
is: CHEBI:57865
name: UMP(2-)
is: HMDB00288
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_3ef27de7_10f3_43ec_aad2_52a979035a2f
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: SLC26A1
has only substance units: false
is encoded by: hsa:10861

metaM ksi pre1 g
constant: false
has only substance units: false
is: HMDB00175
type: Species
initial concentration: 1.0
notes: FORMULA: C79H129N5O57X CHARGE: -1
name: keratan sulfate I biosynthesis, precursor 1
is: C00130
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58053

metaR G6PDH1rer
product: MODEL1310110062#
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110062#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000269

metaR NACHEX1ly
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110062#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110062#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_617bb6fd_973f_4602_9a6e_0d4ee669c302
type: Species
is: P34059
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2588
boundary condition: true
has only substance units: false
name: GALNS
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_a28b31f9_38ed_427f_a2f9_957a090fdd23
is: P09923
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: ALPI
initial concentration: NaN
is encoded by: hsa:248
constant: false
initial amount: NaN

metaM 10fthf m
is: HMDB00972
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57454
type: Species
name: 10-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaM 2dodtricoa m
name: 2,6,9-dodecatrienoylcoa
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
type: Species
is: HMDB03952
initial amount: NaN
is: C05280

http://identifiers.org/biomodels.db/MODEL1310110062#_8293c17a_5a9e_4160_8b5c_8176173f8d0e
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1806
has only substance units: false
boundary condition: true
is: Q12882
name: DPYD
constant: false
initial concentration: NaN
type: Species

metaM HC01406 m
has only substance units: false
initial amount: NaN
is: CHEBI:28264
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: 3-Oxooctanoyl-CoA
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267

http://identifiers.org/biomodels.db/MODEL1310110062#_7bcaed5d_8bbe_4a56_b658_50cc712ceea4
is: B4DUG1
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: SLC24A1
is encoded by: hsa:9187
type: Species
initial amount: NaN
initial concentration: NaN

metaM dlnlcgcrn m
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01311
has only substance units: false
is: CHEBI:16004
initial amount: NaN
name: dihomo-gamma-linolenyl carnitine
is: SBO:0000247
type: Species
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3

metaR GPIMTer L
is: SBO:0000176
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110062#
fast: false
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
kinetic law: MODEL1310110062#

metaR r1598
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM val L c
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00883
constant: false
is: CHEBI:16414
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
boundary condition: false
is: SBO:0000247
name: L-valine

http://identifiers.org/biomodels.db/MODEL1310110062#_a31691b0_b4e9_4673_a469_9dcb1d93d4ef
is encoded by: hsa:2645
constant: false
is: Q53Y25
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: GCK

metaM ac e
type: Species
has only substance units: false
is: HMDB00042
boundary condition: false
name: acetate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30089
is: SBO:0000247
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

http://identifiers.org/biomodels.db/MODEL1310110062#_de8153eb_e2fd_4eb2_ad3e_3988e0b3e7c0
initial concentration: NaN
is: SBO:0000252
is: P23786
is encoded by: hsa:1376
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: CPT2
has only substance units: false

metaR A4GALTg
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
product: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.228
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110062#
name: Lactosylceramide 4-alpha-galactosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110062#_cfba3f0a_c848_4338_9a07_9f15d397e002
boundary condition: true
is encoded by: hsa:1956
name: EGFR
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is: P00533
initial concentration: NaN

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaR r2333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true

metaR PRAGSr
reversible: true
type: Reaction
name: phosphoribosylglycinamide synthase
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.1.2.2
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_43b746d4_1fc2_4897_8c19_3cd12c1a9b71
initial amount: NaN
type: Species
is encoded by: hsa:51102
boundary condition: true
name: MECR
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q9BV79

http://identifiers.org/biomodels.db/MODEL1310110062#_8035cc2f_b5a2_4f95_b234_dc6b98d31ec0
has only substance units: false
name: CTPS2
is: Q9NRF8
type: Species
is encoded by: hsa:56474
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaM 3tdcrn e
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H41NO5 CHARGE: 0
has only substance units: false
type: Species
name: 3-hydroxy-tetradecanoyl carnitine
is: HMDB13336
is: SBO:0000247

metaM ksii core4 pre9 g
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 9
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaM biocyt n
has only substance units: false
is: HMDB03134
type: Species
is: C05552
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM 3mox4hoxm c
boundary condition: false
type: Species
constant: false
name: 3-Methoxy-4-hydroxymandelate
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
is: HMDB00291
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27622
is: SBO:0000247
has only substance units: false

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_9fcf6a59_c691_469a_a64b_d751d101a3ce
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
is: P51687
is encoded by: hsa:6821
name: SUOX

metaR r1599
is: SBO:0000185
reversible: true
product: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_f6c93488_22d4_4964_9bf6_31e6d050eb6d
has only substance units: false
boundary condition: true
name: ST3GAL3
type: Species
is encoded by: hsa:6487
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_df9ea814_3dfc_4662_aac2_26f857e6a2c7
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: NME1
is encoded by: hsa:4830
has only substance units: false
is: P15531
type: Species
boundary condition: true

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR r2332
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185

metaR ECOAH9m
is described by: ECO:0000304
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110062#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
product: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR TYRCBOX
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
name: L-Tyrosine carboxy-lyase
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#

metaR CYTK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
modifier: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
type: Reaction
name: cytidylate kinase (CMP,UTP),nuclear
product: MODEL1310110062#
is described by: ECO:0000269

metaR FORt2m
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD,IT
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: formate mitochondrial transport
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_f7460182_4adf_4497_a094_48f160fd28ce
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:7378
is: Q16831
initial concentration: NaN
constant: false
type: Species
name: UPP1
is: SBO:0000252

metaR AG13T17g
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110062#
fast: false
type: Reaction
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110062#_fa904a62_3e65_46ad_8baa_c92af8823237
name: GALT
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: B4E097
is encoded by: hsa:2592
type: Species
boundary condition: true
is: SBO:0000252

metaM val L e
name: L-valine
type: Species
initial concentration: 1.0
is: HMDB00883
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
boundary condition: false

metaR r0755
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110062#

metaR RE3003M
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110062#
type: Reaction
name: RE3003
kinetic law: MODEL1310110062#
reversible: true

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR FACOAL205
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
modifier: MODEL1310110062#
is described by: ECO:0000000
name: fatty-acid--CoA ligase
reactant: MODEL1310110062#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM 3tdcrn c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C21H41NO5 CHARGE: 0
constant: false
initial amount: NaN
name: 3-hydroxy-tetradecanoyl carnitine
type: Species
is: HMDB02014

metaR r2335
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#

metaR TAGt
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: triacylglycerol transport
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185

metaM 4hoxpacd c
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
boundary condition: false
is: CHEBI:15621
type: Species
is: SBO:0000247
has only substance units: false
name: (4-hydroxyphenyl)acetaldehyde
is: HMDB03767
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r1010
product: MODEL1310110062#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
type: Reaction

metaR r0754
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:

metaR FUT14g
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110062#
modifier: MODEL1310110062#
name: Galactoside 2-alpha-L-fucosyltransferase 1
reactant: MODEL1310110062#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.69

metaR FUMSO4tm
reversible: true
kinetic law: MODEL1310110062#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
is: SBO:0000185
name: Fumarate:sulfate antiport, mitochondrial

metaM nh4 e
initial amount: NaN
name: ammonium
boundary condition: false
is: HMDB00051
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938

metaR GLCAASE8ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110062#
name: beta-glucuronidase, lysosomal
reversible: false
fast: false
product: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000269
kinetic law: MODEL1310110062#

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_ac845229_e69e_4282_9a78_405a49b08f58
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6533
name: SLC6A6
is: Q9BRI2

metaR FAOXC150m
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid (odd chain)
product: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reversible: false
kinetic law: MODEL1310110062#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_96b15951_fbcb_46d3_9c4e_3f275cff399f
constant: false
is: P19961
initial concentration: NaN
type: Species
name: AMY2B
boundary condition: true
is encoded by: hsa:280
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_053e8f5c_658f_43d0_83e3_f4b5ddae2827
type: Species
is encoded by: hsa:211
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P13196
initial concentration: NaN
constant: false
name: ALAS1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_eea80ff7_0645_4567_af76_281f5b2a40a4
name: NAGA
constant: false
is: SBO:0000252
is encoded by: hsa:4668
is: P17050
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM thf m
name: 5,6,7,8-Tetrahydrofolate
is: C00101
boundary condition: false
is: HMDB01846
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57453
type: Species
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9eb8e234_6c63_4e04_8496_bb354e348c6e
is: Q8WWX8
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:115584
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC5A11

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_61edca47_e9cd_4624_8929_3488808e2117
has only substance units: false
name: ATP5H
is: A0PJH2
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:10476
boundary condition: true
initial concentration: NaN
constant: false

metaR r2334
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
is: SBO:0000185
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_84ce1aa7_01ac_407d_974f_ffb5fd52021b
type: Species
name: _AA502753_1_m
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA502753
has only substance units: false
initial amount: NaN
boundary condition: true

metaR D3AIBTm
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reversible: true
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is described by: ECO:0000000
is: SBO:0000176

metaR ABO5g
reactant: MODEL1310110062#
is: SBO:0000176
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is version of: http://identifiers.org/ec-code/2.4.1.37
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reversible: false
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000269

metaR r1594
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_34f3ca57_ab39_4750_b974_ab7c884b3da0
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1215
initial amount: NaN
is: Q4FEB3
type: Species
name: CMA1

metaM crn c
is: CHEBI:16347
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00318
is: SBO:0000247
constant: false
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
type: Species

metaR RE1254C
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
fast: false
product: MODEL1310110062#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
name: RE1254
kinetic law: MODEL1310110062#
reversible: true

metaR It
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
name: Iodide uniport
product: MODEL1310110062#
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_dd99ff6d_2e9a_48b5_b7e5_d72a37231046
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:412
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: STS
is: P08842

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR LEUKTRE4t
fast: false
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
type: Reaction
name: leukotriene E4 transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_5629687d_67ba_4053_9b7c_3917ad550484
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: AMD1
is encoded by: hsa:262
type: Species
is: P17707
has only substance units: false
initial concentration: NaN

metaR FACOAL203
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110062#_b6fed764_dfab_47a4_86a9_25e5e70c256d
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:NOS2A
name: _NOS2A_1_c
boundary condition: true

metaR r0603
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.12
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
kinetic law: MODEL1310110062#

metaR DOLPMT2 Ler
kinetic law: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
product: MODEL1310110062#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110062#

metaR RE3301C
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110062#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.4.4
name: RE3301

metaR r1595
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR MAOX
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.21
name: Methylamine oxidase
type: Reaction
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB
is described by: ECO:0000304
product: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
reversible: false

metaM dcdp c
name: dCDP
is: SBO:0000247
is: CHEBI:58593
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01245
boundary condition: false
is: C00705
type: Species
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaM itp n
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: HMDB00189
boundary condition: false
name: ITP(3-)
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57614

http://identifiers.org/biomodels.db/MODEL1310110062#_67251045_e976_424c_ad97_aa0b9a6a3a34
is: SBO:0000252
type: Species
name: ACADS
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:35
is: P16219

metaR H6ET3er
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.1
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
product: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110062#
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum

metaM octdececrn c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_c3b948e0_44d4_4852_b81a_f82062b8b613
has only substance units: false
type: Species
is encoded by: hsa:6487
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: ST3GAL3
initial amount: NaN

metaR FACOAL204
name: fatty-acid--CoA ligase
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR DESAT22 1p
fast: false
type: Reaction
product: MODEL1310110062#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)

metaM 34hpp m
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00707
constant: false
type: Species
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
boundary condition: false
is: CHEBI:36242

metaR r1596
fast: false
kinetic law: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

metaR IPDPtx
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110062#
name: Isopentenyl diphosphate transport (peroxisome)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_b01c7b3f_2360_446c_8fc5_c292272ab963
name: SLC22A5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6584
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: O76082
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_f1ce1ca6_4a81_41d0_b362_0c7a2db8b17f
is encoded by: hsa:3988
type: Species
name: LIPA
is: SBO:0000252
has only substance units: false
constant: false
is: P38571
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR FALDH
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110062#
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110062#
name: formaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false

metaR FACOAL200
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110062#
name: fatty-acid--CoA ligase
modifier: MODEL1310110062#
fast: false
is: SBO:0000176

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM crn e
name: L-Carnitine
initial amount: NaN
is: C00318
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00062
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_18333c4f_eaf1_412c_8cc7_1b716bd53c14
is encoded by: hsa:28976
boundary condition: true
type: Species
is: Q9H845
initial concentration: NaN
constant: false
initial amount: NaN
name: ACAD9
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_2eae8754_59c6_44da_b7d0_2430590b8b8d
is: D9HTE9
is encoded by: hsa:6576
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC25A1
type: Species
initial concentration: NaN

metaM mescon m
initial concentration: 1.0
is: CHEBI:36986
is: SBO:0000247
constant: false
name: Mesaconate
is: HMDB00749
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
type: Species
has only substance units: false
initial amount: NaN

metaM ac c
type: Species
initial concentration: 1.0
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00042
constant: false
initial amount: NaN
is: CHEBI:30089

metaM tmndnc c
name: timnodonic acid C20:5, n-3
initial concentration: 1.0
is: HMDB01999
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
type: Species
is: http://identifiers.org/pubchem.compound/446284
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_d15b1589_dcc5_4a38_ad19_ada7d1c25344
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P59796
constant: false
has only substance units: false
name: GPX6
is encoded by: hsa:257202
initial amount: NaN
type: Species

metaR EX c4dc
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_4c3ac581_905e_477b_bf50_56880a68d435
has only substance units: false
is encoded by: hsa:2876
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: GPX1
constant: false

metaR r1597
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_9fefd814_ee8f_4edf_a378_47c8d06a88df
is encoded by: hsa:3945
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: LDHB
has only substance units: false
initial amount: NaN
is: P07195
constant: false
type: Species

metaM acgam r
name: N-acetyl-D-glucosamine
is: CHEBI:17411
is: SBO:0000247
initial concentration: 1.0
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
type: Species

metaR A MANASEly
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
reversible: false
name: alpha-mannosidase, lysosomal
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
is: SBO:0000176
product: MODEL1310110062#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.24

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_80616793_f87b_4ab7_b8a3_431eb616f24f
is: Q16706
has only substance units: false
is encoded by: hsa:4124
name: MAN2A1
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaM 5aizc c
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
initial concentration: 1.0
is: CHEBI:58564
type: Species
is: HMDB06273
is: C04751
boundary condition: false

metaM hmbil c
type: Species
is: HMDB01137
boundary condition: false
is: SBO:0000247
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
constant: false
name: Hydroxymethylbilane
initial concentration: 1.0
is: C01024
initial amount: NaN
is: CHEBI:57845
has only substance units: false

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR r2338
reactant: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
kinetic law: MODEL1310110062#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110062#

metaR FAOXC163GC142m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_3b838e65_2d13_4648_92c4_f838e0460c30
initial concentration: NaN
has only substance units: false
is: P52789
boundary condition: true
type: Species
name: HK2
constant: false
is encoded by: hsa:3099
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_e1779735_695f_4d42_b573_8bf235982e8a
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q9Y231
name: FUT9
is encoded by: hsa:10690
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR GMPR
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.7.1.7
reactant: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
product: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
name: GMP reductase
is: SBO:0000176
fast: false

metaR r2103
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
product: MODEL1310110062#

metaM tmndnc e
constant: false
name: timnodonic acid C20:5, n-3
is: SBO:0000247
is: HMDB01999
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
type: Species
is: http://identifiers.org/pubchem.compound/446284

http://identifiers.org/biomodels.db/MODEL1310110062#_c408e10c_05e5_4ca6_bdac_5807ed9592a1
is: P49441
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3628
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: INPP1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_50c5f2bf_c90a_4f59_b528_6f550c8ad089
name: ALDH3A1
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:218
initial concentration: NaN
is: P30838
type: Species

metaR FAOXC184m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaM met L e
is: CHEBI:16643
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: HMDB00696
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR LNELDCCRNt
type: Reaction
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: transport into the mitochondria (carnitine)

http://identifiers.org/biomodels.db/MODEL1310110062#_97bfc3c1_0414_40da_a83d_db3c6cde45f7
is encoded by: hsa:728441
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: GGT2
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM air c
type: Species
is: SBO:0000247
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C03373
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
has only substance units: false
constant: false
is: HMDB01235
is: CHEBI:58592

metaR r2102
type: Reaction
product: MODEL1310110062#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
reversible: true

metaM thf c
constant: false
is: SBO:0000247
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
is: HMDB01846
boundary condition: false
is: CHEBI:57453
type: Species
initial amount: NaN

metaM HC02149 m
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:28867
has only substance units: false
boundary condition: false
name: O-Propanoylcarnitine

metaR r1260
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110062#
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110062#
name: EC:6.2.1.3
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_3be4761a_335a_4376_b1b6_80d0f74e09ed
initial amount: NaN
is: SBO:0000252
name: _NM_001929_1_c
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:NM 001929

metaR FAOXC7C5m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaM gthrd r
initial amount: NaN
constant: false
is: CHEBI:57925
boundary condition: false
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
initial concentration: 1.0
type: Species
name: glutathionate(1-)
is: HMDB00125

metaR FTCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.5
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
modifier: MODEL1310110062#
product: MODEL1310110062#
name: formimidoyltransferase cyclodeaminase
reactant: MODEL1310110062#
fast: false
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110062#
reversible: false

metaM hpdcacoa c
initial amount: NaN
boundary condition: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
has only substance units: false
type: Species
name: heptadecanoyl coa
constant: false
is: HMDB06497
initial concentration: 1.0
is: SBO:0000247

metaR MAL Lte
reversible: true
fast: false
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Transport of L-malate
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_08b83d0d_7201_41e2_ab59_97677f8bfe06
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: GMPR2
is encoded by: hsa:51292
initial concentration: NaN
boundary condition: true
is: Q86T14
type: Species
constant: false

metaM acgam l
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:17411
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
name: N-acetyl-D-glucosamine
has only substance units: false
constant: false

metaM nh4 m
boundary condition: false
is: SBO:0000247
is: CHEBI:28938
initial concentration: 1.0
has only substance units: false
constant: false
name: Ammonium
is: HMDB00051
is: C01342
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
type: Species

metaR r2105
product: MODEL1310110062#
modifier: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM pail hs n
has only substance units: false
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194

metaM ksi pre29 g
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
is: CHEBI:28067
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 29
boundary condition: false

metaR VACCt
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
name: fatty acid transport via diffusion
reversible: true
is: SBO:0000185
reactant: MODEL1310110062#

metaR 34DHOXPEGOX
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110062#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110062#
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.99.24
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB

metaR r1487
name: EC:6.2.1.3
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR ADPACDAc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR r2104
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_22188140_5b59_41d7_b75d_5669e2d54b8e
has only substance units: false
constant: false
type: Species
is: A8MU28
initial concentration: NaN
is: SBO:0000252
name: NAE1
is encoded by: hsa:8883
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_d895f797_00d1_4ea1_8210_41f4e6487da5
name: ST3GAL2
type: Species
constant: false
boundary condition: true
is: Q16842
has only substance units: false
initial amount: NaN
is encoded by: hsa:6483
is: SBO:0000252
initial concentration: NaN

metaM lnlc r
has only substance units: false
name: linoleate
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00673
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595

http://identifiers.org/biomodels.db/MODEL1310110062#_78c5bd27_21fd_44d7_9a35_46c0e936968b
is: SBO:0000252
is encoded by: hsa:51179
name: HAO2
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_93743466_ca9f_44ef_9f5a_4ba5b9d57d3a
constant: false
has only substance units: false
initial amount: NaN
name: INPP4B
initial concentration: NaN
is encoded by: hsa:8821
boundary condition: true
is: O15327
type: Species
is: SBO:0000252

metaR DSAT
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
reactant: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
name: dihydrosphingosine N-acyltransferase
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#

metaR LYSOXp
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
name: L-lysine oxidase, peroxisomal
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b1cffa44_1b6a_40de_b909_46590be9ee8d
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: P49448
boundary condition: true
initial concentration: NaN
type: Species
name: GLUD2
is encoded by: hsa:2747

metaM ksi deg5 l
name: keratan sulfate I, degradation product 5
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110062#_9cd4e651_23b8_4bc2_8033_b72d324342fa
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: P55084
has only substance units: false
name: HADHB
is: SBO:0000252
constant: false
is encoded by: hsa:3032

metaM dolglcp L r
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:15812
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
boundary condition: false
type: Species

metaM tetdec2crn e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0
type: Species
initial amount: NaN
is: HMDB05066

http://identifiers.org/biomodels.db/MODEL1310110062#_542c6e00_e777_4518_8c48_658519ec19f4
initial amount: NaN
is encoded by: hsa:5244
name: ABCB4
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaR NDPK6
name: Nucleoside-diphosphate kinase (ATP:dUDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR G14T17g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110062#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#

metaM fald c
is: CHEBI:16842
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB01426
initial amount: NaN
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false

metaR S6T11g
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000176
product: MODEL1310110062#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110062#_18467cc4_d399_4b31_b8fa_9757d2ec97ba
is: P27707
type: Species
has only substance units: false
is encoded by: hsa:1633
name: DCK
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_65ea9883_27d8_4594_b1de_89f57c26caab
constant: false
has only substance units: false
boundary condition: true
type: Species
name: BDH1
is encoded by: hsa:622
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_548e8166_d951_41c9_93b5_9c369684fafa
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:113235
boundary condition: true
constant: false
name: SLC46A1
is: Q96NT5
initial amount: NaN
has only substance units: false

metaR SAMHISTA
is described by: ECO:0000269
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
fast: false
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.1.1.8
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_8175fccb_ef3b_4364_884e_682a4e035f85
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:26275
initial concentration: NaN
constant: false
initial amount: NaN
is: Q6NVY1
name: HIBCH
boundary condition: true

metaR NRPPHRSFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110062#
name: norepinephrine sulfate transport (diffusion)
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
is: SBO:0000185
type: Reaction

metaR DURIK1
is version of: http://identifiers.org/ec-code/2.7.1.21
name: deoxyuridine kinase (ATP:Deoxyuridine)
is: SBO:0000176
modifier: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
fast: false
is described by: ECO:0000254
type: Reaction
kinetic law: MODEL1310110062#
reversible: false
product: MODEL1310110062#

metaR r2107
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110062#
fast: false

metaR 3MOPt2im
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110062#
type: Reaction
fast: false
reversible: false
product: MODEL1310110062#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
reversible: true
name: NODe
reactant: MODEL1310110062#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_99d045fa_a50f_4a99_b52a_2918234177a7
is encoded by: hsa:AA278423
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: _AA278423_1_c

metaR FAOXC163C143m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

metaM etoh e
is: SBO:0000247
is: HMDB00108
is: CHEBI:16236
boundary condition: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: ethanol
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_33424c2e_15f9_4e75_a1be_5fa90567f758
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:251
name: ALPPL2
constant: false
is: P10696

metaR NDPK7
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dCDP)
reversible: true
fast: false

metaM 5aop c
boundary condition: false
initial concentration: 1.0
is: HMDB01149
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: SBO:0000247
constant: false
is: CHEBI:17549
has only substance units: false
initial amount: NaN
is: C00430
name: 5-Amino-4-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110062#_fa2db667_3f71_423c_8905_5b633e995e09
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: SLC26A11
is encoded by: hsa:284129
is: Q86WA9
has only substance units: false
is: SBO:0000252
constant: false

metaR FAOXC226C225m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_a44c190b_9ab4_42a6_b585_385162bd54f6
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:11136
name: SLC7A9
is: P82251
constant: false
initial concentration: NaN

metaR r2106
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110062#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110062#
modifier: MODEL1310110062#

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM tetdec2crn c
initial amount: NaN
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB02014
initial concentration: 1.0
type: Species
boundary condition: false

metaR BTNPLm
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
product: MODEL1310110062#
reversible: false
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
fast: false
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110062#

metaR DLNLCGCPT2
reversible: false
modifier: MODEL1310110062#
product: MODEL1310110062#
name: carnitine transferase
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR FAOXC161C161OHm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR CO2t
reactant: MODEL1310110062#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
name: CO2 transporter via diffusion
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false

metaR NDPK8
name: Nucleoside-diphosphate kinase (ATP:dADP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110062#
is described by: ECO:0000269
product: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
type: Reaction
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r2109
reversible: true
reactant: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
is: SBO:0000185
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_2610f1e5_53fd_43a1_9034_d8f96d4cb07e
constant: false
name: ATP1B3
initial concentration: NaN
initial amount: NaN
is: P54709
is: SBO:0000252
has only substance units: false
is encoded by: hsa:483
type: Species
boundary condition: true

metaM CE2424 m
initial amount: NaN
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
type: Species
is: CHEBI:28387
is: HMDB11123
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9b43bcf2_eb0b_403f_9142_b3ee9e9d68d2
initial concentration: NaN
is: O43674
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4711
type: Species
name: NDUFB5
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_8465b963_6247_4baa_9119_2e3b1313c581
is: Q9NY65
is: SBO:0000252
constant: false
name: EHHADH
boundary condition: true
is encoded by: hsa:1962
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_912f94ea_289e_461f_980d_279e04b3de96
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC22A2
type: Species
is encoded by: hsa:6582
is: SBO:0000252
constant: false
initial concentration: NaN

metaM met L c
is: SBO:0000247
constant: false
is: CHEBI:16643
boundary condition: false
is: HMDB00696
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: L-methionine

http://identifiers.org/biomodels.db/MODEL1310110062#_965198da_8643_4ebc_8aff_bfe58ccfca6a
constant: false
boundary condition: true
name: _AI191472_1_c
initial amount: NaN
is encoded by: hsa:AI191472
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_7a1968a1_2b54_4aae_9f0e_6e27e54b69d1
boundary condition: true
is encoded by: hsa:2352
name: FOLR3
has only substance units: false
initial concentration: NaN
is: Q05C14
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaM gthrd m
is: CHEBI:57925
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00125
name: glutathionate(1-)
boundary condition: false
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

metaR DLNLCGCPT1
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR BIOCYTtn
type: Reaction
is: SBO:0000185
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
reversible: true
fast: false
name: biocytin transport, nuclear
is described by: ECO:0000000
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_61f4d9bb_0e00_4cb6_8040_55bd62da980d
name: CHAT
initial amount: NaN
is encoded by: hsa:1103
initial concentration: NaN
is: Q6LEN6
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaM etoh c
initial amount: NaN
is: SBO:0000247
is: HMDB00108
boundary condition: false
is: CHEBI:16236
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
has only substance units: false
name: ethanol
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_f1da9a76_72f0_4b29_bb22_0f25842919a2
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: PIGO
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84720

metaR r2108
modifier: MODEL1310110062#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction

metaR r1167
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is: SBO:0000176
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: EC:2.3.1.26
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110062#
reversible: false
fast: false

metaR NDPK9
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
kinetic law: MODEL1310110062#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP)
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000269
fast: false

metaM ksi pre21 g
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
is: HMDB00175
is: C00130
name: keratan sulfate I biosynthesis, precursor 21
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7

http://identifiers.org/biomodels.db/MODEL1310110062#_30934af8_472d_4e11_a522_5e9fd962cf9e
has only substance units: false
is encoded by: hsa:349565
type: Species
initial amount: NaN
constant: false
name: NMNAT3
is: Q96T66
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_6f649ae8_4095_4853_bac5_5beef57efff1
is: B1AK53
is encoded by: hsa:83715
initial concentration: NaN
initial amount: NaN
name: ESPN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_cb780302_c0e0_4876_be6c_21cf8eda2123
constant: false
is encoded by: hsa:2109
boundary condition: true
initial amount: NaN
name: ETFA:ETFB
has only substance units: false
is encoded by: hsa:2108
type: Species
is: SBO:0000297
initial concentration: NaN
has part: P13804

metaM gcald c
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:17071
is: SBO:0000247
constant: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
has only substance units: false
is: HMDB03344
name: glycolaldehyde
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_5a9e9f58_5689_40b3_a542_996c7ea86de7
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PLCB1
is: Q9NQ66
is encoded by: hsa:23236

metaR DM gpi sig er
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR XOL27OHtm
reversible: true
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110062#
name: 27 hydroxy cholesterol transport
type: Reaction
reactant: MODEL1310110062#
fast: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_2479216f_3948_4ee8_a1fd_331c37ab99cb
boundary condition: true
constant: false
initial amount: NaN
name: SULT1A1
is: SBO:0000252
is encoded by: hsa:6817
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_89ce8d81_b2e8_474e_99dc_f21bf65565c0
has only substance units: false
boundary condition: true
type: Species
is: Q9Y2C3
name: B3GALT5
is encoded by: hsa:10317
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaR PGI
is: SBO:0000176
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is version of: http://identifiers.org/ec-code/5.3.1.9
product: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000134
kinetic law: MODEL1310110062#
type: Reaction
reversible: true
fast: false
name: glucose-6-phosphate isomerase

http://identifiers.org/biomodels.db/MODEL1310110062#_b4982028_48d3_4114_b685_564728f52e43
is encoded by: hsa:763
name: CA5A
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is: P35218

http://identifiers.org/biomodels.db/MODEL1310110062#_7f7c9fde_f90f_472f_8736_38547bede6e1
is encoded by: hsa:6392
is encoded by: hsa:6390
initial concentration: NaN
name: SDHA:SDHB:SDHC:SDHD
has part: Q99643
initial amount: NaN
has part: P21912
has only substance units: false
is: SBO:0000297
is encoded by: hsa:6391
constant: false
has part: P31040
boundary condition: true
has part: O14521
type: Species
is encoded by: hsa:6389

metaM lnlc l
is: SBO:0000247
is: HMDB00673
initial amount: NaN
name: linoleate
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
type: Species
is: CHEBI:30245

http://identifiers.org/biomodels.db/MODEL1310110062#_9bee662b_f9bc_45f8_b48b_fb8e1e144f5e
initial amount: NaN
is: SBO:0000252
is: Q9NR34
has only substance units: false
initial concentration: NaN
is encoded by: hsa:57134
type: Species
boundary condition: true
constant: false
name: MAN1C1

metaM HC01223 m
type: Species
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57340
initial amount: NaN
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: SBO:0000247

metaR PACCOAL
fast: false
reversible: false
product: MODEL1310110062#
name: phenylacetate-CoA ligase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

metaM nh4 x
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
is: C01342
is: CHEBI:28938
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00051
has only substance units: false
type: Species
name: Ammonium

metaR DECDICRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR EX cl LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Chloride
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_577211c4_67f2_4245_9924_a3521c109e57
name: FUK
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:197258
initial amount: NaN
is: Q8N0W3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_9367a814_6d28_41d6_aa03_c9691a9f4f53
boundary condition: true
name: _HG2846_HT2983_1_c
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:HG2846-HT2983
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_17e92d63_66f9_4f0e_998c_9a6809cb4b36
is: P09972
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: ALDOC
initial concentration: NaN
is encoded by: hsa:230
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_3c800820_40d2_4731_b517_b168288e8d1a
boundary condition: true
initial amount: NaN
name: SLC7A8
is: SBO:0000252
type: Species
is: Q86U05
has only substance units: false
is encoded by: hsa:23428
constant: false
initial concentration: NaN

metaM ascb L c
initial amount: NaN
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
type: Species
constant: false
name: L-ascorbate
is: CHEBI:38290
has only substance units: false
initial concentration: 1.0
is: HMDB00044
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_681a86fd_1c5a_4c76_b887_41f7a6ec6a68
constant: false
initial amount: NaN
is encoded by: hsa:92745
is: Q8WUX1
boundary condition: true
has only substance units: false
type: Species
name: SLC38A5
is: SBO:0000252
initial concentration: NaN

metaM acgam c
is: HMDB00215
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
constant: false
name: N-acetyl-D-glucosamine
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_ed544a9c_f718_4722_8bb7_3cfbd6e4d1e2
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: ST3GAL3
is: Q5T4Y1
constant: false
initial amount: NaN
is encoded by: hsa:6487

metaR FAOXC227C226m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaR C161OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_98a5a926_d88e_4aaf_8baa_4f746d41db36
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: O60331
constant: false
is encoded by: hsa:23396
boundary condition: true
name: PIP5K1C
has only substance units: false

metaR LINKDEG2ly
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
fast: false
reactant: MODEL1310110062#
reversible: false
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
type: Reaction
kinetic law: MODEL1310110062#

metaR METyLATthc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_c5ab7f71_0b17_4b1e_a5cf_ff87f84a97a8
type: Species
name: ADH1A:ADH1C
constant: false
is: SBO:0000297
initial concentration: NaN
has only substance units: false
has part: P00326
initial amount: NaN
is encoded by: hsa:126
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_26550bf6_c13a_4d16_9b0a_bb0565309f7b
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: Q308M7
is encoded by: hsa:5169
name: ENPP3
initial amount: NaN
type: Species

metaM hpdcacoa m
has only substance units: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
boundary condition: false
is: SBO:0000247
is: HMDB06497
initial concentration: 1.0
name: heptadecanoyl coa
type: Species
initial amount: NaN
constant: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR PGK
is version of: http://identifiers.org/ec-code/2.7.2.3
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
name: phosphoglycerate kinase
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000176
fast: false
reversible: true

metaM dcdp m
type: Species
is: CHEBI:58593
constant: false
name: dCDP(3-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01245

metaM c4crn c
is: C02862
type: Species
boundary condition: false
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
has only substance units: false
name: butyryl carnitine
initial amount: NaN
notes: FORMULA: C11H21NO4 CHARGE: 0
is: SBO:0000247
constant: false

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR FMNAT
fast: false
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
name: FMN adenylyltransferase
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.2

http://identifiers.org/biomodels.db/MODEL1310110062#_4fe1f728_ad6d_4855_9147_cf9ccc43b471
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6715
initial concentration: NaN
is: SBO:0000252
is: P18405
type: Species
name: SRD5A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_a17bafb0_1901_43ad_9220_f7ee50cc79b5
name: PIK3CG
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P48736
is encoded by: hsa:5294
is: SBO:0000252

metaM HC02149 c
boundary condition: false
initial amount: NaN
name: O-Propanoylcarnitine
is: SBO:0000247
is: CHEBI:28867
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_4e079637_a510_418a_a157_1ffb8f695065
is encoded by: hsa:158
constant: false
has only substance units: false
initial amount: NaN
name: ADSL
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM ksi pre2 g
name: keratan sulfate I biosynthesis, precursor 2
is: C00130
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
type: Species
is: SBO:0000247
is: HMDB00175

metaR DHORD9
is: SBO:0000185
is described by: ECO:0000269
name: dihydoorotic acid dehydrogenase (quinone10)
fast: false
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.5.2
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )

http://identifiers.org/biomodels.db/MODEL1310110062#_7068bc3d_3ad0_4050_b608_a1cfdf8068a2
initial amount: NaN
is encoded by: hsa:1329
has only substance units: false
is: SBO:0000252
boundary condition: true
name: COX5B
type: Species
is: Q53YB7
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_42932df3_e9d2_4565_b174_a307b3ab8e90
is: SBO:0000252
initial concentration: NaN
is: Q16795
has only substance units: false
boundary condition: true
name: NDUFA9
initial amount: NaN
constant: false
is encoded by: hsa:4704
type: Species

metaR ENGASEly
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
product: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

metaM udpg c
constant: false
is: HMDB00286
has only substance units: false
is: C00029
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: UDPglucose
is: CHEBI:58367

metaR FUMm
name: fumarase, mitochondrial
modifier: MODEL1310110062#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.2
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
type: Reaction

metaM dcdp n
is: CHEBI:58593
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01245
is: SBO:0000247
initial amount: NaN
name: dCDP(3-)
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaM crn r
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: (R)-carnitine
is: HMDB00062

http://identifiers.org/biomodels.db/MODEL1310110062#_948381f8_f73d_45d6_963d_dca290594faa
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false
is: Q9H2B4
name: SLC26A1
is encoded by: hsa:10861
initial concentration: NaN

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_a7fbcd98_e64c_45cb_a5e2_6b4367332130
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ADH1C
initial amount: NaN
has only substance units: false
is encoded by: hsa:126
constant: false
is: P00326
type: Species

metaR L LACt2r
fast: false
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
name: L-lactate reversible transport via proton symport
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185

metaM camp c
is: HMDB00058
is: CHEBI:58165
has only substance units: false
type: Species
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 3',5'-cyclic AMP(1-)
initial concentration: 1.0

metaR H2Oter
is described by: ECO:0000000
product: MODEL1310110062#
reversible: true
name: H2O endoplasmic reticulum transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
type: Reaction

metaM ca2 c
is: HMDB00464
constant: false
is: SBO:0000247
initial amount: NaN
name: calcium(2+)
has only substance units: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial concentration: 1.0
boundary condition: false
is: CHEBI:29108
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_20bd5fe1_1f9f_4854_9c94_6e60246ebc2c
initial amount: NaN
boundary condition: true
has only substance units: false
is: C9JT23
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:126328
is: SBO:0000252
name: NDUFA11

metaR THYOXt2
reversible: true
product: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
name: T4 transport via facilitated diffusion
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ

metaM arach c
is: CHEBI:32360
name: arachidate
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: HMDB02212
type: Species

metaR NRPPHRSULT
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
product: MODEL1310110062#
name: Norepinephrine Sulfotransferase
fast: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110062#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_eebf9ce1_9baa_4193_983f_7eb821d2648f
has only substance units: false
type: Species
name: SLC34A1
is: SBO:0000252
is: Q7Z725
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6569
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_e927f7a5_61df_4897_a6b6_b6b3d58d06d1
is encoded by: hsa:4705
constant: false
name: NDUFA10
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: O95299
initial amount: NaN
has only substance units: false
type: Species

metaR RE3367E
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110062#
name: RE3367
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.4.3.22

http://identifiers.org/biomodels.db/MODEL1310110062#_24737d30_7302_4e92_b9b0_944059dfecaa
is: Q06055
is: SBO:0000252
name: ATP5G2
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:517
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_71eebdcf_1187_49c8_9435_3affa19661d6
is: P19174
initial concentration: NaN
is encoded by: hsa:5335
name: PLCG1
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false

metaR C51CPT1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaM sebcoa x
name: sebacoylcoa
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247

metaR ARGtm
reversible: true
is described by: ECO:0000269
name: arginine mitochondrial transport via ornithine carrier
fast: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is: SBO:0000185

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
is described by: ECO:0000212
product: MODEL1310110062#
reactant: MODEL1310110062#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
type: Reaction
is: SBO:0000176

metaR NACHEX2ly
is: SBO:0000176
modifier: MODEL1310110062#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
type: Reaction

metaM ksi deg41 l
is: CHEBI:12936
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C34H58N2O26 CHARGE: 0
name: keratan sulfate I, degradation product 41
has only substance units: false
initial amount: NaN
is: HMDB00143

metaR AMPtp
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
name: AMP transporter, peroxisome
kinetic law: MODEL1310110062#

metaM udpg e
constant: false
is: HMDB00286
is: CHEBI:58367
type: Species
initial concentration: 1.0
boundary condition: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
has only substance units: false
is: SBO:0000247

metaR PHEMEt
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
is: SBO:0000185
name: heme transport
product: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_2b83cff6_8fe5_47ad_8b22_80795f46b9a8
name: FUT8
is: Q9BYC5
constant: false
is encoded by: hsa:2530
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

metaR PGDI
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.99.2
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
name: Prostaglandin-H2 D-isomerase [Precursor]
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
reactant: MODEL1310110062#
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_991b7684_e4ea_41d9_803a_c4fb6719c221
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q674R7
initial concentration: NaN
is encoded by: hsa:285973
name: ATG9B

http://identifiers.org/biomodels.db/MODEL1310110062#_5ee03e82_2418_4114_ab8c_a177618eaff0
is: SBO:0000252
boundary condition: true
is: P17812
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: CTPS1
is encoded by: hsa:1503
initial amount: NaN

metaM dgmp e
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: dGMP(2-)
constant: false
is: HMDB01044
initial concentration: 1.0
is: CHEBI:57673
has only substance units: false

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR r2100
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110062#
reversible: true

metaM 5aop m
is: HMDB01149
is: C00430
constant: false
is: CHEBI:17549
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
has only substance units: false
initial concentration: 1.0
name: 5-Amino-4-oxopentanoate
type: Species

metaM focytC m
initial amount: NaN
constant: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
has only substance units: false
name: Ferrocytochrome C
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:16928

metaM ppcoa m
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: Propanoyl-CoA
type: Species
is: C00100
is: SBO:0000247
is: CHEBI:57392

metaR RE1233C
is: SBO:0000176
type: Reaction
product: MODEL1310110062#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
reversible: true
name: RE1233
modifier: MODEL1310110062#

metaM lnlc e
type: Species
is: HMDB00673
initial concentration: 1.0
is: CHEBI:30245
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
constant: false
name: linoleate

http://identifiers.org/biomodels.db/MODEL1310110062#_cd581da4_0aaf_4c5f_8140_ae221118d86d
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ECI2
boundary condition: true
is encoded by: hsa:10455
is: O75521
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_5888e74c_a3c6_4ebf_95d1_341b70ae4e42
initial amount: NaN
type: Species
is encoded by: hsa:6785
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: Q9GZR5
name: ELOVL4
has only substance units: false

metaR PItn
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: phosphate transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110062#_4e178b2a_2588_44b5_be0a_23b747b2af37
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ADH1A
is: P07327
is: SBO:0000252
is encoded by: hsa:124

http://identifiers.org/biomodels.db/MODEL1310110062#_9b600857_4e77_4142_9abb_882168beb46d
is: SBO:0000252
type: Species
is encoded by: hsa:BF195998
has only substance units: false
name: _BF195998_1_x
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaM for m
is: HMDB00142
boundary condition: false
is: CHEBI:15740
name: formate
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
initial amount: NaN

metaR G14T2g
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110062#
fast: false

metaR r2101
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110062#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110062#
reactant: MODEL1310110062#

metaR CMPACNAtg
fast: false
product: MODEL1310110062#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
modifier: MODEL1310110062#
is described by: ECO:0000269
name: CMP-Sia Golgi transport via CMP antiport
reactant: MODEL1310110062#
reversible: true

metaM dnad c
is: C00857
initial amount: NaN
is: CHEBI:18304
initial concentration: 1.0
is: SBO:0000247
is: HMDB01179
name: Deamino-NAD+
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
boundary condition: false
has only substance units: false
constant: false
type: Species

metaR PEPCKm
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.1.1.32
name: Phosphoenolpyruvate carboxykinase (GTP)
is: SBO:0000176
modifier: MODEL1310110062#
reversible: false
fast: false
is described by: ECO:0000000

metaR S23T3g
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is version of: http://identifiers.org/ec-code/2.4.99.6
fast: false
reversible: false
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_5497cacf_72d9_41cb_9d2a_c261a54ef399
is: Q14916
is encoded by: hsa:6568
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC17A1
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

metaR IDPtn
kinetic law: MODEL1310110062#
is: SBO:0000185
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
reversible: true
type: Reaction
name: IDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR RE0688E
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
name: RE0688
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#

metaR r1591
fast: false
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#
product: MODEL1310110062#

metaM dolglcp L c
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
has only substance units: false
constant: false
is: CHEBI:15812

metaM ksi deg3 l
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:30825
is: SBO:0000247
is: HMDB00573
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 3

metaM 2dp6mobq me m
initial amount: NaN
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
has only substance units: false
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:50772

metaM dgmp c
is: CHEBI:57673
constant: false
is: C00362
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
initial amount: NaN
name: dGMP
boundary condition: false

metaM g1p e
type: Species
is: CHEBI:58601
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
constant: false
is: SBO:0000247
is: HMDB01586
boundary condition: false
initial concentration: 1.0
name: alpha-D-glucose 1-phosphate(2-)

metaR CITL
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
is: SBO:0000176
name: Citrate lyase
modifier: MODEL1310110062#
fast: false

metaR r1590
is described by: ECO:0000000
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110062#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1019
product: MODEL1310110062#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110062#
type: Reaction
fast: false
kinetic law: MODEL1310110062#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaM for c
is: C00058
boundary condition: false
is: SBO:0000247
is: HMDB00142
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
name: Formate
has only substance units: false
constant: false
type: Species
is: CHEBI:15740

http://identifiers.org/biomodels.db/MODEL1310110062#_37d06f51_8b34_4c26_9fb9_15d0e1a65521
initial concentration: NaN
type: Species
name: PIK3CA:PIK3R2
is encoded by: hsa:5290
constant: false
initial amount: NaN
has part: O00459
has part: P42336
has only substance units: false
is encoded by: hsa:5296
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110062#_ce048ff4_6670_466c_ba7c_ac02e153b813
constant: false
name: PFAS
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: Q6P4B4
initial amount: NaN
is encoded by: hsa:5198

metaM odecoa r
constant: false
is: HMDB01322
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57387
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
name: oleoyl-CoA(4-)

metaR F1Atg
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
reversible: true
name: F1alpha transport (from golgi to lysosome)
is: SBO:0000185
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000

metaM kdn c
is: HMDB00425
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H15O9 CHARGE: -1 INCHI: InChI=1/C9H16O9/c10-2-5(13)7(15)8(16)6(14)3(11)1-4(12)9(17)18/h3,5-8,10-11,13-16H,1-2H2,(H,17,18)/t3-,5-,6+,7+,8+/m0/s1
constant: false
is: SBO:0000247
boundary condition: false
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid
type: Species
has only substance units: false

metaM malttr e
is: HMDB01262
initial amount: NaN
name: maltotriose
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
has only substance units: false
constant: false
is: C01835
boundary condition: false
type: Species
is: CHEBI:27931
initial concentration: 1.0

metaR COUCOAFm
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: p-coumaroyl-CoA formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .

metaM lnlc c
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: CHEBI:30245
boundary condition: false
name: linoleate
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00673
initial concentration: 1.0
type: Species

metaR FAOXC181C181OHm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaM ac m
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:30089
is: HMDB00042
type: Species
has only substance units: false
name: acetate
is: SBO:0000247

metaR THMMPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: true
fast: false
is described by: ECO:0000000
name: Thiamine monophosphate transport, mitochondrial
reactant: MODEL1310110062#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_c1674e49_1e70_47fb_b547_ff758802263a
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: _AI824319_1_r
is encoded by: hsa:AI824319

metaR r1593
reversible: true
is: SBO:0000185
reactant: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
fast: false

metaM sucsal m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57706
boundary condition: false
has only substance units: false
is: HMDB01259
name: Succinic semialdehyde
constant: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232

http://identifiers.org/biomodels.db/MODEL1310110062#_2c28b3c8_c7c4_440b_b3f0_295288b241e7
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P28845
name: HSD11B1
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:3290
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_2e4f2071_bc1b_411b_8bd6_325da26210e8
initial concentration: NaN
is encoded by: hsa:1103
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: P28329
constant: false
name: CHAT

metaM 2hexdtetcoa m
initial amount: NaN
boundary condition: false
type: Species
name: 2,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110062#_ffba640b_6af1_4cd3_a4e6_d09bb8cd1862
has part: O60762
is encoded by: hsa:8818
is: SBO:0000297
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:54344
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8813
name: DPM3:DPM1:DPM2
has part: Q86TM7
has part: O94777

metaR r1018
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
product: MODEL1310110062#
name: Transport reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR ATPS4m
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.4.6
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.6.1.14
name: ATP synthase (four protons for one ATP)
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
reversible: false
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.6.3.14

http://identifiers.org/biomodels.db/MODEL1310110062#_405393c6_ea5e_4cab_85f4_413f7655885d
initial amount: NaN
is: Q8TD20
constant: false
initial concentration: NaN
name: SLC2A12
boundary condition: true
has only substance units: false
is encoded by: hsa:154091
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_49ca224d_50ee_4600_af83_d089f4d90af7
boundary condition: true
name: _AV717590_1_m
is encoded by: hsa:AV717590
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM memgacpail hs r
has only substance units: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: CHEBI:15809
is: SBO:0000247

metaM g1p c
type: Species
has only substance units: false
is: CHEBI:58601
name: D-Glucose 1-phosphate
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01586
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial concentration: 1.0
is: C00103

metaR CSPG Atly
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110062#
name: chondroitin sulfate A transport, extracellular to lysosome
reactant: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#

metaR r1592
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR GLYCTO1p
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.3.15
name: Glycolate oxidase, peroxisome
modifier: MODEL1310110062#
fast: false
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is: SBO:0000176

metaM val L m
initial amount: NaN
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: L-valine
initial concentration: 1.0

metaM lnlccoa m
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01064
name: linoleic coenzyme A
constant: false
has only substance units: false
is: SBO:0000247

metaR SEBACIDTD
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_d3a53759_caef_4c8b_a3d6_de9d59dd86c3
constant: false
is encoded by: hsa:217
is: P05091
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: ALDH2

metaM 4mzym int2 r
name: 4-Methylzymosterol intermediate 2
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06838
constant: false
is: SBO:0000247

metaM dad 2 c
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:17256
has only substance units: false
type: Species
constant: false
name: 2-deoxyadenosine
is: HMDB00101

metaM dlnlcgcrn c
is: SBO:0000247
name: dihomo-gamma-linolenyl carnitine
is: HMDB01311
boundary condition: false
is: CHEBI:16004
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
constant: false

metaR ACETONEt2
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
modifier: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
name: acetone transport via proton symport
is described by: ECO:0000269
fast: false
product: MODEL1310110062#
is: SBO:0000185

metaR ABO6g
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.37
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
is: SBO:0000176
product: MODEL1310110062#
reversible: false
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

metaR ALCD2yf
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
fast: false

metaM ppbng c
is: SBO:0000247
has only substance units: false
is: C00931
initial concentration: 1.0
is: CHEBI:58126
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
is: HMDB00245
initial amount: NaN
constant: false
boundary condition: false
name: Porphobilinogen
type: Species

metaR GLYt2r
reversible: true
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: glycine reversible transport via proton symport
modifier: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_7c0cdc24_abc9_451d_a811_62c3140c38d6
is: SBO:0000252
constant: false
name: FUCA1
is encoded by: hsa:2517
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: P04066
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_78964474_c11c_4c74_ae2f_12b0576815a1
name: DDO
type: Species
boundary condition: true
is: Q99489
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8528
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_29392ffe_a5e3_4bcd_a241_4d5bafc3f16f
type: Species
boundary condition: true
constant: false
is: Q308M7
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ENPP3
is encoded by: hsa:5169

metaR CHOLK
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
name: Choline kinase
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176

metaM odecoa m
initial concentration: 1.0
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
constant: false
is: CHEBI:57387
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247

metaM 5HPET c
type: Species
initial concentration: 1.0
is: CHEBI:57450
is: SBO:0000247
name: 5(S)-HPETE(1-)
boundary condition: false
is: HMDB01193
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1

metaR r1377
fast: false
is described by: ECO:0000000
product: MODEL1310110062#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
reversible: true
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_73cd143a_7532_41dd_a003_b4e9389c3d85
initial concentration: NaN
is: Q6NVC0
is encoded by: hsa:292
boundary condition: true
name: SLC25A5
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9b68067c_6f4d_4b68_8675_81b0c3dc2f6e
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: _LOC647190_1_c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:LOC647190
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_c264d45e_a5bc_4dc4_93aa_6c9462f25c5f
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:3081
type: Species
boundary condition: true
name: HGD
has only substance units: false
is: Q93099

metaR NACHEXA13ly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_0083d31e_d700_4e93_bbe9_40629febe699
type: Species
initial concentration: NaN
name: ATP5L
is encoded by: hsa:10632
is: SBO:0000252
boundary condition: true
is: O75964
constant: false
initial amount: NaN
has only substance units: false

metaR MI14Ptn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_347d88fe_c896_4788_a659_527b42977e50
initial amount: NaN
initial concentration: NaN
name: NT5C1B
is encoded by: hsa:93034
is: B3KUK6
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_ae12983e_08a4_4ace_b3fa_fb9b906d3936
boundary condition: true
has part: F8W7V3
has only substance units: false
is encoded by: hsa:517
constant: false
is: SBO:0000297
initial amount: NaN
type: Species
is encoded by: hsa:9551
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_a7e43005_e46d_4ff7_8172_cfbb76cd3da8
type: Species
is: Q6FGQ4
constant: false
boundary condition: true
is: SBO:0000252
name: PPT1
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5538

metaR PItx
is: SBO:0000185
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Phosphate transporter, peroxisome

metaM itp e
is: CHEBI:57614
boundary condition: false
initial concentration: 1.0
name: ITP(3-)
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_94792762_51bb_4af2_b343_624235296e52
is encoded by: hsa:5293
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: A7E2E0
name: PIK3CD

metaR AG13T18g
type: Reaction
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#

metaM lpro m
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
has only substance units: false
boundary condition: false
is: CHEBI:15804
is: SBO:0000247
name: Lipoylprotein
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

metaR S2L2N2M2MASNtly
is: SBO:0000185
reversible: false
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110062#
name: s2l2n2m2masn transport, extracellular to lysosome
type: Reaction
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_86d4acd4_c11e_4e18_a8f4_d952d06baad5
name: SLC4A8
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9498
is: E7EML0
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_0d64c18b_3a16_44d4_80bf_1e378e3af26a
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC13A1
is: Q9BZW2
is encoded by: hsa:6561
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b48b315a_5e4a_4057_bfb2_45719b7fd375
is: P15104
initial concentration: NaN
is encoded by: hsa:2752
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GLUL

metaM 2hexdtricoa m
is: SBO:0000247
name: 2,7,10-hexadecatrienoylcoa
type: Species
has only substance units: false
initial amount: NaN
is: HMDB02288
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaM crn m
is: SBO:0000247
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
type: Species
is: CHEBI:16347
is: C00318
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00062
has only substance units: false

metaR INSTt2r
product: MODEL1310110062#
reversible: true
name: inositol transport in via proton symport
fast: false
is: SBO:0000185
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:

metaR RE3624M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
name: RE3624
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
modifier: MODEL1310110062#

metaR C5DCe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM ahdt e
initial amount: NaN
is: SBO:0000247
is: CHEBI:58462
constant: false
has only substance units: false
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
initial concentration: 1.0
is: HMDB00980
type: Species
boundary condition: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR CMPACNAtn
product: MODEL1310110062#
type: Reaction
name: CMP-Sia nuclear export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false
reversible: false
kinetic law: MODEL1310110062#
is: SBO:0000185

metaR r2330
is described by: ECO:0000000
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110062#_f460c3a4_2b76_4eef_970a_6f15eceaf322
initial concentration: NaN
type: Species
is: SBO:0000252
name: CDIPT
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:10423
is: O14735
initial amount: NaN

metaR UMPK2n
name: UMP kinase (CTP),nuclear
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r2331
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110062#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110062#
reversible: true

metaR r2404
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR HPDCACRNt
reversible: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
name: heptadecanoate transport into the mitochondria
fast: false
type: Reaction
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#

metaM ksi pre22 g
has only substance units: false
is: HMDB00175
type: Species
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 22
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: C00130
constant: false
is: SBO:0000247
is: CHEBI:58053

metaM for e
constant: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
name: formate
initial concentration: 1.0
is: HMDB00142
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_06d939f0_8aa7_4cf4_bed1_831e3fd22a00
initial concentration: NaN
has only substance units: false
type: Species
is: E9PB82
constant: false
is encoded by: hsa:3295
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: HSD17B4

http://identifiers.org/biomodels.db/MODEL1310110062#_7c46a106_5131_4146_be59_62c9fac6afc4
is encoded by: hsa:5298
name: PI4KB
boundary condition: true
is: SBO:0000252
is: Q9UBF8
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaM ascb L e
has only substance units: false
constant: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
name: L-ascorbate
initial amount: NaN
boundary condition: false
is: HMDB00044
type: Species
is: CHEBI:38290
initial concentration: 1.0
is: SBO:0000247

metaM itp c
initial concentration: 1.0
type: Species
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00189
name: ITP(3-)
is: CHEBI:57614
initial amount: NaN

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaR ACOAD1fm
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reversible: false
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is: SBO:0000176
product: MODEL1310110062#

metaM CE2420 m
is: SBO:0000247
initial concentration: 1.0
is: HMDB11123
boundary condition: false
type: Species
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: CHEBI:28387
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_3004946c_8f70_40bd_8668_935e790c8f56
name: PLCL1
boundary condition: true
is: Q15111
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:5334

metaR r1378
is: SBO:0000176
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_a02ff168_872f_4c1f_9fac_08344b5615c4
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q99714
constant: false
name: HSD17B10
boundary condition: true
is encoded by: hsa:3028
type: Species
initial amount: NaN

metaR FAOXC204
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM 3hexdcrn c
has only substance units: false
name: 3-hydroxyhexadecanoylcarnitine
notes: FORMULA: C23H45NO5 CHARGE: 0
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB13336
is: SBO:0000247
initial concentration: 1.0

metaR H7 TAer
type: Reaction
kinetic law: MODEL1310110062#
reversible: false
is: SBO:0000176
product: MODEL1310110062#
name: H7' transamidase, endoplasmic reticulum
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_4eaf2fce_31f6_4170_ba98_922737802f83
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1119
constant: false
name: CHKA
is: P35790
has only substance units: false

metaM HC01407 m
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
name: (S)-Hydroxyhexanoyl-CoA
is: CHEBI:28276
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM dd5ecoa m
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB13028
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
name: 5-dodecenoylcoa
is: SBO:0000247
is: C01942
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_a0e0173f_d5ef_41da_a4ac_9f5697dd3e01
name: _728226_1_e
has only substance units: false
constant: false
is encoded by: hsa:728226
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM tym c
is: CHEBI:327995
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: tyraminium
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
type: Species
is: HMDB00306

metaR ASNGLNNaEx
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185
reversible: false
product: MODEL1310110062#
fast: false
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
kinetic law: MODEL1310110062#

metaM HC02217 c
is: CHEBI:27647
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: prostaglandin-g2

metaR SIAASEly
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110062#
name: sialidase, lysosomal
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110062#
is: SBO:0000176

metaR PYNP2r
name: pyrimidine-nucleoside phosphorylase (uracil)
product: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.2.3
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110062#

metaM acnacngal14acglcgalgluside hs c
is: CHEBI:3338
name: 3',8'-LD1
is: C00036
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00223
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_13f5b43f_e08d_4949_9e6d_e0b678db818c
type: Species
is encoded by: hsa:54677
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: E7EQF2
name: CROT
is: SBO:0000252

metaM frdp x
is: HMDB00961
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:175763
name: farnesyl pyrophosphate(3-)

metaM gluside hs c
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:18368
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM acetone e
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: acetone
is: CHEBI:15347
constant: false
is: HMDB01659
has only substance units: false

metaM atp c
name: ATP(4-)
initial amount: NaN
has only substance units: false
is: HMDB00538
is: CHEBI:30616
is: C00002
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaR MI1PP
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
is: SBO:0000176
reactant: MODEL1310110062#
name: myo-inositol 1-phosphatase
modifier: MODEL1310110062#
type: Reaction
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_34d7f3b9_acdd_44a1_b7c1_1e01cebbc244
is: SBO:0000252
name: GALNT9
type: Species
is encoded by: hsa:50614
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q9HCQ5
initial amount: NaN

metaR r1630
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c8b67502_9d1c_4fe7_9f72_22e46eb82d55
has only substance units: false
initial amount: NaN
name: VNN3
initial concentration: NaN
is encoded by: hsa:55350
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaM 3hexdcrn e
initial concentration: 1.0
boundary condition: false
name: 3-hydroxyhexadecanoylcarnitine
constant: false
initial amount: NaN
is: HMDB13336
notes: FORMULA: C23H45NO5 CHARGE: 0
has only substance units: false
is: SBO:0000247
type: Species

metaR r0679
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110062#_f7685ce9_2ac7_4ba1_b94b_85d0e47dff2e
is encoded by: hsa:3613
initial amount: NaN
name: IMPA2
has only substance units: false
is: O14732
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9eadb8a7_1190_4b49_9e4d_2f2ce80acc9f
boundary condition: true
is: P14415
type: Species
initial concentration: NaN
has only substance units: false
name: ATP1B2
constant: false
is: SBO:0000252
is encoded by: hsa:482
initial amount: NaN

metaM trp L e
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: L-tryptophan
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247
is: HMDB00929
is: CHEBI:16828

metaM c4crn e
is: SBO:0000247
initial amount: NaN
name: butyryl carnitine
has only substance units: false
initial concentration: 1.0
is: C02862
notes: FORMULA: C11H21NO4 CHARGE: 0
is: HMDB02013
constant: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/213144

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
is: CHEBI:57847
is: HMDB00304
type: Species
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
constant: false
boundary condition: false

metaR GTMLTe
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
reversible: false
name: g-glutamyltransferase (e)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_cfcf83eb_bc69_4438_bbde_4edd6a8b01e9
has only substance units: false
is: SBO:0000252
name: SUCLG1
is: P53597
is encoded by: hsa:8802
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaM 3oddcoa m
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB03937
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3-Oxododecanoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: CHEBI:27868

metaM dopasf c
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: HMDB06275
has only substance units: false
initial amount: NaN
name: dopamine 3-O-sulfate
initial concentration: 1.0
is: CHEBI:37946

metaR 5ADTSTSTERONESte
name: sulfonated testosterone transport
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110062#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_a69400d6_d5c0_40ef_b89d_4248251a9cbe
is: Q7LG56
has only substance units: false
initial concentration: NaN
is encoded by: hsa:50484
initial amount: NaN
constant: false
boundary condition: true
name: RRM2B
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_29f4d1a5_198b_4740_aa99_06f83124af36
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3028
initial amount: NaN
has only substance units: false
name: HSD17B10
is: Q99714
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_b9acd5a8_1c8f_498c_89a2_0a9dd4eec3a1
initial concentration: NaN
initial amount: NaN
type: Species
is: P42765
name: ACAA2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10449
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_180357db_2f9e_4f02_b23b_99a44cd7c46c
initial amount: NaN
is: SBO:0000252
constant: false
is: F8VQS7
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:55967
name: NDUFA12

metaM HC02217 e
name: prostaglandin-g2
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial concentration: 1.0
constant: false
is: CHEBI:27647

metaM ksii core2 deg5 l
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 5
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: CHEBI:12936
is: SBO:0000247
constant: false
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_77b9452d_c494_4ae8_9e03_dac0fda44494
boundary condition: true
constant: false
initial concentration: NaN
name: HIBADH
is: P31937
is: SBO:0000252
type: Species
is encoded by: hsa:11112
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_dd13708d_0437_4840_ac9a_d5ad83ad65fa
is encoded by: hsa:64077
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: LHPP
is: Q9H008
constant: false
is: SBO:0000252
type: Species

metaM HC02187 c
is: SBO:0000247
name: reverse-triiodthyronine
type: Species
is: CHEBI:28774
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
boundary condition: false

metaM 20ahchsterol m
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
boundary condition: false
name: 20-hydroxycholesterol
is: SBO:0000247
is: CHEBI:1296
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: HMDB06283

metaR FRDPtr
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
fast: false

metaM atp e
initial amount: NaN
constant: false
is: HMDB00538
name: ATP(4-)
is: SBO:0000247
type: Species
is: CHEBI:57299
is: C00002
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR RE2659R
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110062#
reversible: true
name: RE2659
reactant: MODEL1310110062#

metaR r1632
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_fdd07186_2f7d_4287_b762_0e47c14e8b6c
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:206
type: Species
has only substance units: false
name: _206_1_c

metaR SUCCTD
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_1f46d6c7_bc54_4f86_aaec_af1da5bdf087
has only substance units: false
name: ACAT2
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:39
is: Q9BWD1
initial amount: NaN

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_f91745da_2eb6_486c_88cd_92954657c82a
type: Species
is: P78542
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3098
initial concentration: NaN
name: HK1
is: SBO:0000252
has only substance units: false

metaM trp L c
is: CHEBI:16828
name: L-tryptophan
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00929

metaM acnacngal14acglcgalgluside hs g
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
initial concentration: 1.0
is: CHEBI:3338
constant: false
name: 3',8'-LD1
is: SBO:0000247
is: HMDB00223
initial amount: NaN
is: C00036
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_7d66b36e_ed5d_41f6_921d_ace18bda5603
has only substance units: false
initial amount: NaN
constant: false
is: P23434
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:2653
name: GCSH
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_a593857e_8d0c_4486_865a_9e30f5d817e5
initial concentration: NaN
is: SBO:0000252
name: B3GNT8
is encoded by: hsa:374907
is: Q7Z7M8
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species

metaM hco3 c
type: Species
is: HMDB00595
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
name: Bicarbonate
is: SBO:0000247
is: C00288
is: CHEBI:17544
constant: false
has only substance units: false
initial amount: NaN

metaR r1631
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false

metaM pyr c
is: CHEBI:15361
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00243
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1
name: pyruvate
constant: false
is: C00022

metaR FAOXC101C8m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaR RE1845X
is described by: ECO:0000000
type: Reaction
fast: false
name: RE1845
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110062#

metaR ARACHDtr
is: SBO:0000185
name: intracellular transport
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR RE0691C
reversible: true
type: Reaction
fast: false
name: RE0691
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaM gluside hs g
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
type: Species
has only substance units: false
boundary condition: false

metaM gbside hs l
has only substance units: false
is: CHEBI:18259
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
initial amount: NaN
name: globoside
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_1608ca73_b73d_49d0_a047_4f6d201c2383
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: Q9NRR6
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:56623
name: INPP5E

http://identifiers.org/biomodels.db/MODEL1310110062#_0899f3c4_ce55_433e_aee6_f192406a27df
is: Q5FC00
type: Species
constant: false
is: SBO:0000252
name: CA6
has only substance units: false
initial amount: NaN
is encoded by: hsa:765
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_4bbfb1b8_f164_44ae_a9b7_5441c878536c
is encoded by: hsa:54963
constant: false
name: UCKL1
initial amount: NaN
has only substance units: false
is: Q53HM1
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR TETHEX3t
type: Reaction
is: SBO:0000185
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: true
name: fatty acid transport via diffusion
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR r1634
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110062#

metaR C141ACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaM 4hbz m
is: CHEBI:17879
name: 4-hydroxybenzoate
is: HMDB00500
type: Species
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaM h2o x
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15377
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
name: H2O
type: Species
is: HMDB02111
constant: false
is: SBO:0000247
is: C00001

metaR r1088
reversible: true
is: SBO:0000185
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110062#
type: Reaction
name: Active transport

metaR TAURt4 2 r
product: MODEL1310110062#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: taurine transport (sodium symport) (2:1)
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000185
modifier: MODEL1310110062#
type: Reaction
reversible: true

metaM h2o2 c
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
has only substance units: false
type: Species
name: Hydrogen peroxide
initial concentration: 1.0
is: CHEBI:16240
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00027
constant: false

metaM ksi pre30 g
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00175
boundary condition: false
is: CHEBI:58053
has only substance units: false
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
name: keratan sulfate I biosynthesis, precursor 30
constant: false
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110062#_112e06f6_e127_4146_b2e7_dded3f5d0053
constant: false
initial concentration: NaN
is encoded by: hsa:2882
initial amount: NaN
is: Q96SL4
type: Species
boundary condition: true
name: GPX7
has only substance units: false
is: SBO:0000252

metaM g3m8mpdol L r
constant: false
has only substance units: false
is: CHEBI:37568
is: HMDB01342
boundary condition: false
type: Species
initial amount: NaN
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
is: C00459
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
initial concentration: 1.0

metaM r5p r
initial amount: NaN
is: SBO:0000247
is: HMDB00618
constant: false
type: Species
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
initial concentration: 1.0
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate

metaM pyr e
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial concentration: 1.0
name: pyruvate
has only substance units: false
type: Species
is: HMDB00243
is: CHEBI:15361
is: SBO:0000247

metaM orn m
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: Ornithine
is: C01602
is: CHEBI:46912
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM Ser Thr g
is: CHEBI:58336
has only substance units: false
boundary condition: false
is: HMDB00645
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247

metaM dd2coa m
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB03712
name: trans-dodec-2-enoyl-CoA(4-)
is: CHEBI:57330
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221

metaR r1633
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false

metaR MI1PS
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
is version of: http://identifiers.org/ec-code/5.5.1.4
fast: false
is: SBO:0000176
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
name: myo-Inositol-1-phosphate synthase
is described by: ECO:0000269
modifier: MODEL1310110062#
reversible: false

metaM hco3 e
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
name: Bicarbonate
constant: false
has only substance units: false
is: C00288
type: Species
is: HMDB00595
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:17544
boundary condition: false

metaR AG13T12g
reactant: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110062#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_d7a8cf13_8d8c_4fae_8d58_22d4611d7a83
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: Q8NEB9
is encoded by: hsa:5289
has only substance units: false
name: PIK3C3
type: Species

metaR ILELAT1tc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaM pail34p hs c
initial amount: NaN
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: SBO:0000247
type: Species
is: CHEBI:57658
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

http://identifiers.org/biomodels.db/MODEL1310110062#_f96b4614_23b9_42d1_9d4c_55342a1cee7f
constant: false
is: SBO:0000252
is encoded by: hsa:10846
initial concentration: NaN
has only substance units: false
name: PDE10A
type: Species
is: Q9Y233
initial amount: NaN
boundary condition: true

metaM acnacngal14acglcgalgluside hs e
has only substance units: false
constant: false
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
is: C00036
is: SBO:0000247
name: 3',8'-LD1
is: HMDB00223
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:3338
initial concentration: 1.0

metaM itaccoa m
type: Species
initial amount: NaN
name: itaconyl-CoA(5-)
boundary condition: false
constant: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: HMDB03377
has only substance units: false
initial concentration: 1.0
is: CHEBI:57381
is: SBO:0000247

metaM CE4876 r
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57923
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
initial amount: NaN
name: delta12-Prostaglandin J2

metaR r2139
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110062#
type: Reaction
reversible: true
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_f01d2e2b_20c2_4eeb_8f79_7fcec8fd1652
has only substance units: false
is encoded by: hsa:51809
type: Species
initial amount: NaN
is: Q86SF2
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: GALNT7

http://identifiers.org/biomodels.db/MODEL1310110062#_bfe4a967_aae9_4cb7_ab2f_32c973e5c92b
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: EARS2
initial amount: NaN
constant: false
is: Q5JPH6
is encoded by: hsa:124454

http://identifiers.org/biomodels.db/MODEL1310110062#_5a66adb4_f722_446d_ba7a_22b033f03084
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P07864
constant: false
is encoded by: hsa:3948
name: LDHC
type: Species

metaM h2o2 e
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
initial concentration: 1.0
is: HMDB03125
initial amount: NaN
name: hydrogen peroxide
is: CHEBI:16240

metaM prostgd2 e
is: HMDB01403
has only substance units: false
name: prostaglandin D2(1-)
boundary condition: false
is: CHEBI:57406
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_889eab9d_7240_4ba2_91a5_b9fac4f15ea5
name: ATP5J
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:522
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: Q6IB54
boundary condition: true

metaR TALA
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110062#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.2.1.2
name: transaldolase
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110062#

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_bb6d67f7_04e8_42c6_8f8b_f6a5f37d446e
has part: B4DK61
boundary condition: true
constant: false
has only substance units: false
has part: E9PB82
is encoded by: hsa:51
initial amount: NaN
has part: Q96CA6
is encoded by: hsa:30
initial concentration: NaN
type: Species
name: ACAA1:HSD17B4:ACOX1
is encoded by: hsa:3295
is: SBO:0000297

metaR DESAT22 2p
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110062#
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)

metaM gacpail hs r
initial amount: NaN
name: glucosaminyl-acylphosphatidylinositol
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01401
boundary condition: false
is: CHEBI:61548
initial concentration: 1.0
is: C00092
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110062#_f434954b_4d29_452d_a98d_9e7f782fb46a
initial amount: NaN
boundary condition: true
is: P57054
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: PIGP
is encoded by: hsa:51227

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM h2o r
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: C00001
is: CHEBI:15377
is: SBO:0000247
constant: false
name: H2O
is: HMDB02111

metaR CITtbm
modifier: MODEL1310110062#
name: citrate transport, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
product: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_d7050bf9_b459_4070_a762_0b480a85ca50
boundary condition: true
is encoded by: hsa:6487
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ST3GAL3
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_8593879e_cc71_40c5_96dc_5c1a1f5635ab
has only substance units: false
initial concentration: NaN
is encoded by: hsa:22978
initial amount: NaN
type: Species
name: NT5C2
boundary condition: true
constant: false
is: P49902
is: SBO:0000252

metaM pail34p hs n
is: CHEBI:57658
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM ksii core2 pre10 g
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: CHEBI:28067
has only substance units: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 10
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_89e28520_6a51_4f47_b93b_166dbe36ea51
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:53354
has only substance units: false
name: PANK1
boundary condition: true
is: Q8TE04
initial concentration: NaN

metaR r0545
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
modifier: MODEL1310110062#
reversible: true
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39

metaR P4507A1r
type: Reaction
name: cytochrome P450, family 7, subfamily A, polypeptide 1
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.17

http://identifiers.org/biomodels.db/MODEL1310110062#_564ae9ba_0b4f_4027_89b0_a795eb317ac9
is encoded by: hsa:80347
initial amount: NaN
constant: false
name: COASY
is: Q13057
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM HC02202 c
is: CHEBI:57398
name: prostaglandin A1(1-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
type: Species
initial amount: NaN
constant: false

metaM HC00361 c
is: CHEBI:58335
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
constant: false
name: sedoheptulose 1,7-bisphosphate(4-)
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
has only substance units: false
initial amount: NaN
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
is: HMDB00257
is: CHEBI:16094
type: Species
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b8086075_4117_422b_ae28_49f225084926
is encoded by: hsa:1807
constant: false
has only substance units: false
is: Q14117
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: DPYS

metaM rib D c
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
name: D-ribose
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00283
type: Species
is: CHEBI:16988

metaM asp D x
has only substance units: false
is: CHEBI:29990
initial amount: NaN
name: D-aspartate(1-)
boundary condition: false
constant: false
is: HMDB06483
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
type: Species
is: SBO:0000247

metaM sT antigen g
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16565
is: SBO:0000247
notes: FORMULA: C25H40N2O18X CHARGE: -1
has only substance units: false
boundary condition: false
name: sialyl-T antigen
constant: false

metaM man1p c
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:35374
is: HMDB06330
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
initial amount: NaN
boundary condition: false
name: D-Mannose 1-phosphate
constant: false

metaR TAUBETAtc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaM HC01104 e
constant: false
is: CHEBI:61146
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 4-nitrophenyl phosphate(2-)
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360

metaR MI14P4P
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
name: inositol-1,4-bisphosphate 4-phosphatase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR ACGPID
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: false
is described by: ECO:0000269
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.89
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
fast: false
reactant: MODEL1310110062#

metaM trdrd c
is: SBO:0000247
constant: false
name: Reduced thioredoxin
type: Species
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false
boundary condition: false
is: C00342
initial amount: NaN
initial concentration: 1.0

metaR FAOXC5OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaM atp m
is: SBO:0000247
name: ATP(4-)
constant: false
has only substance units: false
is: C00002
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00538
is: CHEBI:57299
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_6ccba2ec_cad1_4eb3_9b28_865ee8a872ae
boundary condition: true
is: P15309
name: ACPP
is encoded by: hsa:55
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_13072daf_6844_49de_b63d_356d145bf0d7
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AA526438
name: _AA526438_1_m
boundary condition: true

metaR CLOHtex2
type: Reaction
modifier: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000304
name: chloride transport via hydroxide countertransport (2:1)
kinetic law: MODEL1310110062#
fast: false
reversible: false

metaM acglcgalgluside hs g
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
constant: false
is: SBO:0000247
is: CHEBI:17103
has only substance units: false
type: Species
boundary condition: false

metaM prostgd2 c
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
is: CHEBI:57406
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: prostaglandin D2(1-)

http://identifiers.org/biomodels.db/MODEL1310110062#_ace7fd5b_e25e_4502_9395_40d06570cd57
name: ETFDH
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q16134
is encoded by: hsa:2110

metaM rib D e
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
type: Species
constant: false
name: D-ribose
initial concentration: 1.0
boundary condition: false
is: CHEBI:16988
is: SBO:0000247
has only substance units: false

metaR RE3000M
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110062#
name: RE3000
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_4471f88c_a527_4916_9c5f_af5b2a05cede
is encoded by: hsa:56848
initial amount: NaN
type: Species
name: SPHK2
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9NRA0

metaR MACOXO
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
is: SBO:0000176
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.4
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
reversible: false
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_694aa40c_eb33_49fc_b7ec_54b9cddd65f1
initial amount: NaN
has only substance units: false
name: _D29675_1_e
is encoded by: hsa:D29675
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR EX 34hpp
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM CE2435 m
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57795
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
name: trans,cis-deca-2,4-dienoyl-CoA
type: Species
initial concentration: 1.0

metaM pro L m
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
name: L-proline
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00162
is: CHEBI:17203

metaM HC02202 e
is: CHEBI:57398
name: prostaglandin A1(1-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false

metaM frdp r
boundary condition: false
name: Farnesyl diphosphate
initial amount: NaN
has only substance units: false
is: CHEBI:175763
is: C00448
initial concentration: 1.0
type: Species
is: HMDB00961
constant: false
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaR PCm
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.4.1.1
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110062#
name: pyruvate carboxylase
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
product: MODEL1310110062#
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110062#

metaM atp n
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: SBO:0000247
name: ATP(3-)
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57299
type: Species
is: HMDB00538

http://identifiers.org/biomodels.db/MODEL1310110062#_c2a162e4_1aff_4681_a9ab_06eb772848f9
is encoded by: hsa:1103
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: P28329
boundary condition: true
initial amount: NaN
name: CHAT
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_59abc541_9764_4d98_8333_72e4182e0ccd
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:175
is: P20933
name: AGA

metaR SUBERICACT
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR GLNCYSNaEx
product: MODEL1310110062#
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110062#
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_7ccc398a_9b8c_44f5_b97c_7bcc5292d875
is encoded by: hsa:229
type: Species
constant: false
is: P05062
initial concentration: NaN
name: ALDOB
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_728629d3_7e7b_42a2_b043_20d3931aee44
initial concentration: NaN
boundary condition: true
is: A6NDW6
initial amount: NaN
is encoded by: hsa:79053
is: SBO:0000252
name: ALG8
has only substance units: false
type: Species
constant: false

metaR NADHtru
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
name: NADH transporter, endoplasmic reticulum
kinetic law: MODEL1310110062#
reversible: false

metaM h2o n
initial concentration: 1.0
is: CHEBI:15377
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
is: SBO:0000247
is: HMDB02111
type: Species
boundary condition: false
name: water
constant: false

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaM dcholcoa r
boundary condition: false
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: chenodeoxycholoyl coenzyme a
is: HMDB06292
is: CHEBI:28701
constant: false
type: Species

metaM em2emgacpail hs r
initial amount: NaN
is: CHEBI:16038
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
boundary condition: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
constant: false
is: SBO:0000247
has only substance units: false
type: Species

metaM man6p c
initial amount: NaN
is: CHEBI:17369
boundary condition: false
is: HMDB01078
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: D-Mannose 6-phosphate
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275

http://identifiers.org/biomodels.db/MODEL1310110062#_8ddafd23_df7b_4d16_9f2f_eee51ab160b7
initial amount: NaN
name: SDHD
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6392
is: O14521
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_f922a450_b4af_4b55_82b2_85be312b6cce
is: Q9BYZ2
name: LDHAL6B
type: Species
is encoded by: hsa:92483
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR LNLCCRNt
modifier: MODEL1310110062#
reversible: false
name: transport into the mitochondria (carnitine)
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR PCt
reactant: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
name: phosphatidylcholine transporter
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
modifier: MODEL1310110062#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.44
reversible: true
is described by: ECO:0000269
product: MODEL1310110062#
type: Reaction

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR DNDPt20m
is: SBO:0000185
product: MODEL1310110062#
name: dTDP transport via ATP antiport
modifier: MODEL1310110062#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#

metaR G14T14g
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000

metaM HC02187 e
initial amount: NaN
name: reverse-triiodthyronine
is: CHEBI:28774
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaM cspg e e
type: Species
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
boundary condition: false
has only substance units: false
is: CHEBI:16040
is: HMDB00630
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_49ef5daa_1b4d_4f4d_abb9_42ed32f7118e
name: MTMR3
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:8897
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: Q13615

http://identifiers.org/biomodels.db/MODEL1310110062#_ea5dddc2_e1cd_4988_8b8c_07df2d321ae2
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8659
is: SBO:0000252
type: Species
initial amount: NaN
name: ALDH4A1
is: P30038
constant: false

metaM h2o m
initial concentration: 1.0
name: H2O
is: C00001
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: CHEBI:15377
boundary condition: false
constant: false
is: HMDB02111
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b74ee16a_3cd7_4791_9f3a_4694c850953d
initial amount: NaN
is encoded by: hsa:27068
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: PPA2
is: SBO:0000252

metaR AGTim
is: SBO:0000176
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
type: Reaction
fast: false
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.44

http://identifiers.org/biomodels.db/MODEL1310110062#_fe44ae13_1caa_4ef4_b69d_304e152aa4b8
is: Q9BZV2
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:80704
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: SLC19A3

metaR r0541
reversible: true
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110062#
type: Reaction
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_73dfdaf9_de44_4d63_9ab4_2d2f293f7338
initial amount: NaN
boundary condition: true
is encoded by: hsa:11212
initial concentration: NaN
constant: false
name: PROSC
is: SBO:0000252
type: Species
has only substance units: false
is: O94903

metaM 4hbzcoa m
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 4-hydroxybenoyl-CoA
type: Species
initial amount: NaN
boundary condition: false
is: HMDB06467
has only substance units: false
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1

metaM 5oxpro c
is: HMDB00267
has only substance units: false
boundary condition: false
type: Species
constant: false
is: CHEBI:57606
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
initial concentration: 1.0
name: 5-oxoprolinate

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR RE3381E
fast: false
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
name: RE3381
reversible: true
kinetic law: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110062#
is: SBO:0000176
type: Reaction
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_450044ae_9af5_4622_a8f5_0e47e70acb5a
type: Species
is: P50747
is encoded by: hsa:3141
is: SBO:0000252
has only substance units: false
name: HLCS
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaR NTP3e
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is described by: ECO:0000269
product: MODEL1310110062#
name: nucleoside-triphosphatase (GTP)
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_51e8e6bb_a918_4287_91d5_299157c287f1
is: D9HTE9
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: SLC25A1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6576
boundary condition: true

metaR GGH 6DHFe
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110062#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
reactant: MODEL1310110062#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false

metaR DINt
type: Reaction
product: MODEL1310110062#
name: deoxyinosine transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
is: SBO:0000185

metaR r0788
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110062#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#

metaM gluside hs r
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
initial amount: NaN
is: CHEBI:18368
is: SBO:0000247
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine

metaR 2OXOADPTm
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
fast: false
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
is described by: ECO:0000269
name: 2-oxoadipate shuttle (cytosol/mitochondria)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_6bfdbcec_9eae_44c2_80f6_1c4d188ad8de
has only substance units: false
type: Species
name: MIA3
initial concentration: NaN
is: Q5JRA6
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:375056

http://identifiers.org/biomodels.db/MODEL1310110062#_6fa2768d_41f1_469d_83b4_522d8e76c88b
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:26
name: ABP1
is: SBO:0000252
initial amount: NaN
is: P19801
type: Species
has only substance units: false

metaM gtp c
initial amount: NaN
is: C00044
boundary condition: false
is: SBO:0000247
is: CHEBI:37565
is: HMDB01273
constant: false
name: GTP
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0

metaM acetone c
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: CHEBI:15347
type: Species
name: acetone

metaM Sfglutth c
is: HMDB01550
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
name: S-formylglutathionate(1-)
is: CHEBI:57688
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031

http://identifiers.org/biomodels.db/MODEL1310110062#_108db139_1459_42e2_bfb9_51c355fceb09
has only substance units: false
is encoded by: hsa:W74642
initial concentration: NaN
name: _W74642_1_c
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaR r0789
reversible: true
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110062#
fast: false
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110062#

metaM acglcgal14acglcgalgluside hs g
initial concentration: 1.0
name: nLc5Cer
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
constant: false
is: CHEBI:17103
is: SBO:0000247

metaM atp r
is: CHEBI:57299
has only substance units: false
is: HMDB00538
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: ATP(4-)
is: C00002

metaM 3ddecdicoa m
is: C05280
is: HMDB03952
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: 3,6-dodecadienoylcoa
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_d2e9f049_997f_4205_8461_38bfc35bbf61
is: SBO:0000252
constant: false
is encoded by: hsa:8898
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: MTMR2
is: A6NN98
has only substance units: false
type: Species

metaR CYTK6n
is described by: ECO:0000269
modifier: MODEL1310110062#
fast: false
type: Reaction
reversible: true
name: cytidylate kinase (CMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110062#

metaR PRISTCOAtx
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
product: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110062#
name: pristcoa peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110062#_7ce22369_69db_44ac_94fa_8dcd214e4d4c
is encoded by: hsa:1632
boundary condition: true
is: P42126
initial concentration: NaN
name: ECI1
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR r0268
product: MODEL1310110062#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.1

metaR CYTK5n
type: Reaction
kinetic law: MODEL1310110062#
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9926c4c1_1b3e_4910_b2d6_87dca96cfefd
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: MCCC2
constant: false
is: SBO:0000252
is: Q9HCC0
is encoded by: hsa:64087

metaM cholate c
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
initial concentration: 1.0
type: Species
is: CHEBI:29747
has only substance units: false
boundary condition: false
name: Cholate
initial amount: NaN
is: SBO:0000247
constant: false

metaR FUM
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
modifier: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110062#
name: fumarase
product: MODEL1310110062#
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaM c10dc c
is: HMDB13325
constant: false
name: sebacoyl carnitine
boundary condition: false
notes: FORMULA: C17H30NO6 CHARGE: -1
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_09192b5c_05d0_40b5_8622_ccbb6a4b53db
has only substance units: false
is encoded by: hsa:4122
is: Q9P1E4
constant: false
initial concentration: NaN
boundary condition: true
name: MAN2A2
is: SBO:0000252
initial amount: NaN
type: Species

metaR r2024
product: MODEL1310110062#
reversible: false
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM clpnd c
type: Species
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
is: HMDB06528
name: clupanodonic acid
is: CHEBI:53488
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR HEX1
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
name: hexokinase (D-glucose:ATP)
fast: false
kinetic law: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110062#

metaM c8dc e
is: HMDB00791
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C02838
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H26NO6 CHARGE: -1
type: Species
constant: false
name: suberyl carnitine

metaR THMDt4
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
is: SBO:0000185
reactant: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
reversible: false
is described by: ECO:0000269
fast: false
name: thymidine transport in via sodium symport

metaM glc D r
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00122
initial amount: NaN
is: CHEBI:4167
boundary condition: false
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0
type: Species

metaR r2199
fast: false
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
modifier: MODEL1310110062#
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_2a36292b_98a7_4f3c_8351_0d76cbd01524
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: DGKB
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:1607

metaM pro L c
name: L-proline
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:17203
is: HMDB00162
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaR r0267
fast: false
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.5.1.9
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#

metaR r2198
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR GBSIDEte
fast: false
product: MODEL1310110062#
reversible: true
name: globoside transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185

metaM CE5788 e
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
constant: false
name: kinetensin 1-7
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:27485
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02710

metaM c10dc e
notes: FORMULA: C17H30NO6 CHARGE: -1
name: sebacoyl carnitine
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB13325
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_026d54fa_420f_4776_8506_06635a700b4c
type: Species
is encoded by: hsa:478
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: ATP1A3
is: SBO:0000252
is: B7Z2T0
has only substance units: false

metaM maltpt e
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
name: maltopentaose
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
initial concentration: 1.0
has only substance units: false
constant: false
is: C02052
is: HMDB01296
initial amount: NaN
boundary condition: false

metaR THRASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
fast: false
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000185

metaR C162ACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_eb0cc073_10e1_4029_a5f5_ba48e7eb0639
is encoded by: hsa:AI373818
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: _AI373818_1_m
boundary condition: true
type: Species
initial concentration: NaN

metaR r0797
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
name: glycine N-choloyltransferase EC:2.3.1.65
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_ea3e08ef_fac8_47e4_b86d_c8c0824c5edd
is: G3V5N0
name: FUT8
is encoded by: hsa:2530
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_425c45ed_541e_40ea_96c4_7027ba4bc639
initial amount: NaN
is encoded by: hsa:4967
has part: B4E3E9
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000297
type: Species
name: DLD:DLST:OGDH:PDHX

metaM didp n
name: dIDP
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:28823
initial amount: NaN
has only substance units: false

metaR r0539
fast: false
reversible: true
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
modifier: MODEL1310110062#

metaR ABO9g
is version of: http://identifiers.org/ec-code/2.4.1.37
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
is described by: ECO:0000269
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_10d0e258_2b02_4ee7_aba2_1f52ecc57cb2
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:56301
name: SLC7A10
is: Q9NS82
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_f0e95978_3da6_47d8_a2bb_bdf0ebe4c488
name: _NM_013421_1_m
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:NM 013421
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaR FACOAL140i
name: fatty-acid--CoA ligase (tetradecanoate)
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
product: MODEL1310110062#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
fast: false

metaM cholate e
constant: false
is: SBO:0000247
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial concentration: 1.0
type: Species
is: CHEBI:29747
name: Cholate
initial amount: NaN
is: HMDB00619
boundary condition: false
has only substance units: false

metaM trdrd m
has only substance units: false
name: Reduced thioredoxin
boundary condition: false
initial concentration: 1.0
is: CHEBI:15967
initial amount: NaN
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_4a9a0ee4_baa8_4e08_8131_7900a713af8d
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2531
is: Q06136
constant: false
name: KDSR
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_21f548e0_8caa_4c3b_aac4_bc935cc51e37
boundary condition: true
initial concentration: NaN
is: Q9NVE7
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:55229
initial amount: NaN
name: PANK4

metaM tddedi2coa m
constant: false
has only substance units: false
name: trans2,6dodecadienoylcoa
is: HMDB00792
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
is: C08277

metaM c8dc c
constant: false
is: HMDB00791
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C02838
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C15H26NO6 CHARGE: -1
name: suberyl carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_e1c7b3f7_4377_486e_94a6_abb23fbd166d
name: ACAD10
is: G3XAJ0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:80724

http://identifiers.org/biomodels.db/MODEL1310110062#_8498dfa8_6c5a_4ad0_a884_db283bf4a73c
initial concentration: NaN
type: Species
name: COQ6
is: Q9Y2Z9
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:51004
initial amount: NaN

metaR r0796
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
reversible: true
modifier: MODEL1310110062#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:

metaM cgly c
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00078
has only substance units: false
is: SBO:0000247
name: L-cysteinylglycine
constant: false
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaM thbpt c
is: HMDB00027
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 5,6,7,8-tetrahydrobiopterin
constant: false
initial concentration: 1.0
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: CHEBI:15372
has only substance units: false
type: Species

metaM pro L e
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
type: Species
initial concentration: 1.0
is: CHEBI:17203
is: HMDB00162
boundary condition: false
has only substance units: false

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM nh4 c
type: Species
name: Ammonium
is: HMDB00051
is: CHEBI:28938
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: C01342

http://identifiers.org/biomodels.db/MODEL1310110062#_76bb82b0_521e_447e_816c_df1a71fbc950
has only substance units: false
is encoded by: hsa:10587
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: TXNRD2

http://identifiers.org/biomodels.db/MODEL1310110062#_e67e81cb_0a4b_4b05_acad_297503e89794
initial concentration: NaN
initial amount: NaN
name: B3GNT2
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:10678
has only substance units: false

metaR HEX4
reversible: false
reactant: MODEL1310110062#
type: Reaction
is: SBO:0000176
name: hexokinase (D-mannose:ATP)
is described by: ECO:0000304
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
kinetic law: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2

metaM h2o l
initial amount: NaN
has only substance units: false
name: water
type: Species
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
initial concentration: 1.0
is: CHEBI:15377
boundary condition: false
is: SBO:0000247

metaM asp D c
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
name: D-aspartate(1-)
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:29990
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB06483

metaR FAOXTC102C101m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaR RE3243R
modifier: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
reactant: MODEL1310110062#
name: RE3243
is described by: ECO:0000000
fast: false
type: Reaction

metaR r2195
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_5cb703b8_e9cf_49c5_a02f_c0af3a45129b
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI024818
name: _AI024818_1_c
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR C181OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaM h2o e
is: HMDB02111
is: C00001
has only substance units: false
is: SBO:0000247
name: H2O
is: CHEBI:15377
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_f6fde53f_c8b2_4b87_a88e_71fa741393eb
name: ACOX3
is encoded by: hsa:8310
is: O15254
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR RE1898C
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
kinetic law: MODEL1310110062#
is described by: ECO:0000000
fast: false
name: RE1898
is: SBO:0000176
reversible: true
product: MODEL1310110062#

metaM mpdol L c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:18396
type: Species
initial amount: NaN
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
is: SBO:0000247
constant: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR DURAD2
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
name: dihydrothymin dehydrogenase (NADP)
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2

metaM atp x
is: C00002
is: CHEBI:57299
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: ATP(4-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00538

http://identifiers.org/biomodels.db/MODEL1310110062#_af79dfb6_dccb_4726_bc66_a80bf518b391
is: Q8TB61
type: Species
is encoded by: hsa:347734
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC35B2
has only substance units: false
initial amount: NaN

metaR r2028
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110062#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM glyc3p m
has only substance units: false
initial concentration: 1.0
is: C00093
initial amount: NaN
is: HMDB00126
is: SBO:0000247
constant: false
boundary condition: false
name: Glycerol 3-phosphate
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597

metaM 3mox4hpac m
is: SBO:0000247
boundary condition: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
is: HMDB05175
has only substance units: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:28111

http://identifiers.org/biomodels.db/MODEL1310110062#_cbcdc157_65dc_4b33_a870_3e03d90a2247
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: GGT1
is: P19440
type: Species
is encoded by: hsa:2678
has only substance units: false
initial concentration: NaN

metaM cgly e
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial amount: NaN
boundary condition: false
is: HMDB00078
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: CHEBI:4047
name: L-cysteinylglycine

http://identifiers.org/biomodels.db/MODEL1310110062#_5171c4a1_3a78_4f34_8dfe_ca8c9261417e
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: B3KQ63
is encoded by: hsa:3242
initial amount: NaN
initial concentration: NaN
name: HPD
boundary condition: true

metaR RE0689E
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
modifier: MODEL1310110062#
type: Reaction
name: RE0689
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_870e03b6_3d58_472f_8cc7_061d6973d49c
initial concentration: NaN
is encoded by: hsa:493
initial amount: NaN
is: P23634
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: ATP2B4

http://identifiers.org/biomodels.db/MODEL1310110062#_70b1dfa9_a69a_4e70_b4b3_aa34478a067a
boundary condition: true
is: B7Z1R0
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: SLC4A10
is encoded by: hsa:57282

metaR r2027
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
product: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185

metaR ADRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110062#
name: fatty acid transport via diffusion

metaR RE1523M
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000000
name: RE1523
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110062#_facf8bf0_79c0_47e8_a1b4_95b042714ed7
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:4718
constant: false
initial amount: NaN
is: Q549M5
name: NDUFC2
initial concentration: NaN
is: SBO:0000252

metaR GBSIDEtl
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
reversible: true
fast: false
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
type: Reaction
name: globoside intracellular transport
reactant: MODEL1310110062#

metaR r2197
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110062#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR CMPSAS
is version of: http://identifiers.org/ec-code/2.7.7.43
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reversible: false
is described by: ECO:0000304
name: CMP sialic acid synthase
fast: false
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_f5abbeee_1a56_4a34_9274_47f795574878
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: _AA203143_1_c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA203143

metaM ksi deg2 l
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:30825
type: Species
is: HMDB00573
boundary condition: false
name: keratan sulfate I, degradation product 2
initial amount: NaN
notes: FORMULA: C241H384N17O210S12 CHARGE: -13

metaR C4DCe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of succinyl carnitine into the extra cellular space
type: Reaction

metaR r0680
type: Reaction
modifier: MODEL1310110062#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.137
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
fast: false
reactant: MODEL1310110062#

metaM m4mpdol L r
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:37633
type: Species
is: SBO:0000247
constant: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0

metaM h2o g
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
name: water
is: HMDB02111

metaM ksii core2 pre1 g
initial amount: NaN
is: CHEBI:28067
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C33H53N3O23X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 1
is: SBO:0000247
type: Species
boundary condition: false

metaR UMPK
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000269

metaM clpnd e
is: SBO:0000247
boundary condition: false
name: clupanodonic acid
type: Species
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:53488
has only substance units: false
is: HMDB06528

http://identifiers.org/biomodels.db/MODEL1310110062#_4a86ca0b_5deb_4182_9566_24f0c260ff3e
name: HEXB
initial amount: NaN
constant: false
is: P07686
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3074

metaR r2196
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110062#

metaR FAOXC14C12m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM dsmsterol r
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
type: Species
constant: false
has only substance units: false
is: HMDB02719
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:17737
name: desmosterol

http://identifiers.org/biomodels.db/MODEL1310110062#_3ee11900_ac5b_404d_ba29_225dc2480e63
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:767
has only substance units: false
name: CA8
is: P35219
type: Species

metaM 34dhoxmand c
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:27637
is: HMDB01866
name: 3,4-Dihydroxymandelate
constant: false
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial concentration: 1.0

metaM r5p c
initial amount: NaN
has only substance units: false
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
boundary condition: false
initial concentration: 1.0
is: C00117
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
type: Species
is: HMDB00618

metaR MDHx
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
name: malate dehydrogenase, peroxisomal
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110062#
type: Reaction

metaM acetone m
initial concentration: 1.0
is: HMDB01659
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
has only substance units: false
name: acetone

metaR FE3MTP1
is described by: ECO:0000134
kinetic law: MODEL1310110062#
reversible: false
type: Reaction
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
name: transport of ferrous iron into blood
fast: false
is: SBO:0000185

metaR r2137
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: true

metaR PE HStm
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000185
reversible: true
name: phosphatidylethanolamine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110062#
fast: false

metaM didp c
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB03536
initial amount: NaN
name: dIDP
boundary condition: false
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
constant: false

metaR DM fol
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaM m5masnC g
has only substance units: false
is: HMDB06814
constant: false
boundary condition: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:58401
initial concentration: 1.0

metaR RE0690E
kinetic law: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
name: RE0690
is described by: ECO:0000000
product: MODEL1310110062#
reversible: false

metaR r1623
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#
reactant: MODEL1310110062#

metaR r0791
fast: false
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000176
reversible: true
modifier: MODEL1310110062#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110062#

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_9cd90f22_ee93_433e_9d0a_4a896575c50a
initial concentration: NaN
boundary condition: true
name: B3GALT5
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10317

metaR r0686
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
reversible: true
fast: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR RBTt
reactant: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110062#
name: ribitol transport via passive diffusion

http://identifiers.org/biomodels.db/MODEL1310110062#_7784a95b_d8ab_4527_9ecf_2e77b53f7d6a
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: ALG2
is encoded by: hsa:85365
is: SBO:0000252
has only substance units: false
type: Species

metaR GARFT
type: Reaction
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: phosphoribosylglycinamide formyltransferase
kinetic law: MODEL1310110062#

metaR r2136
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
reversible: false
type: Reaction
reactant: MODEL1310110062#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

http://identifiers.org/biomodels.db/MODEL1310110062#_2c6942b6_fd6f_4583_8d8b_7a0d20ca87ab
is: B4DK61
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:51
initial amount: NaN
name: ACOX1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_e1e5c032_b3fd_4780_90b7_7f46f27e59a5
is: P04179
is encoded by: hsa:6648
type: Species
initial concentration: NaN
boundary condition: true
name: SOD2
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_05394435_18d3_466f_9ba4_20db4b32515f
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: Q96KH8
is encoded by: hsa:6530
has only substance units: false
name: SLC6A2

http://identifiers.org/biomodels.db/MODEL1310110062#_3066dea3_81ab_428c_a838_119bae614d05
has only substance units: false
has part: Q8IV97
name: SLC3A2:SLC7A5
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8140
is: SBO:0000297

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR RE1845C
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
product: MODEL1310110062#
is described by: ECO:0000000
name: RE1845
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
reversible: true
reactant: MODEL1310110062#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c6b624a2_2331_41c8_a00a_8602c088b2b2
initial amount: NaN
name: PLCB3
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:5331
boundary condition: true
is: G5E960
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_2612039f_f78e_4099_bb71_37d8c6c853b0
constant: false
initial concentration: NaN
name: _22305_1_c
is encoded by: hsa:22305
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR r1624
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false

metaR r0899
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
name: Amino acid transporter ATB0+ Facilitated diffusion
is: SBO:0000185
reversible: true
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_b4f12748_4daf_4115_809b_72bd275f5a23
type: Species
is encoded by: hsa:AI926493
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _AI926493_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_325865c0_00fb_431c_8862_629b60ed2904
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:6583
is: Q9H015
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: SLC22A4

http://identifiers.org/biomodels.db/MODEL1310110062#_d987f97c_4cfa_429f_922e_b2a9b112831f
is encoded by: hsa:5959
type: Species
name: RDH5
initial amount: NaN
boundary condition: true
constant: false
is: Q92781
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM h2o c
boundary condition: false
type: Species
name: H2O
is: CHEBI:3303
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00001
initial amount: NaN
has only substance units: false
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0

metaR UMPK7n
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110062#
is: SBO:0000176
type: Reaction
name: UMP kinase (dGTP),nuclear
product: MODEL1310110062#
is described by: ECO:0000269

metaM prostgd2 r
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: prostaglandin D2(1-)
constant: false
is: CHEBI:57406
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_642cd8fc_56ab_4458_9ddd_14aeca9ce19a
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: SLC20A2
is: B2RBR4
is encoded by: hsa:6575
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_7907c6cc_1d1b_40a4_8e7d_7e3317fbeb60
constant: false
initial concentration: NaN
boundary condition: true
is: Q8IWU9
has only substance units: false
type: Species
name: TPH2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:121278

http://identifiers.org/biomodels.db/MODEL1310110062#_fd9f58ca_abd7_4196_a66f_1a3b851bc316
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9487
name: PIGL
is: Q9Y2B2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_e0d39a5f_dccd_40e5_83a4_9d4a669579bc
is encoded by: hsa:51227
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: PIGP
has only substance units: false
is: SBO:0000252

metaR r1625
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110062#
product: MODEL1310110062#

metaM zym int2 r
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial amount: NaN
boundary condition: false
name: zymosterol intermediate 2
is: CHEBI:52386

metaR GALASE7ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
product: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110062#

metaM elaid e
is: HMDB00573
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: CHEBI:30825
constant: false
name: elaidate
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species

metaM gbside hs c
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside
is: CHEBI:18259
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_dfb52951_62e2_4ae3_b013_f4f59827172e
is encoded by: hsa:2806
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: P00505
name: GOT2
boundary condition: true
is: SBO:0000252

metaR PEAMNO
product: MODEL1310110062#
name: Phenethylamine oxidase
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000304
modifier: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
reversible: false
kinetic law: MODEL1310110062#

metaR FACOAL246 1
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
name: fatty-acid--CoA ligase
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110062#
product: MODEL1310110062#

metaM ficytC m
name: Ferricytochrome c
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: SBO:0000247
is: CHEBI:15991
boundary condition: false

metaR r0683
type: Reaction
fast: false
kinetic law: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110062#
is described by: ECO:0000000
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_d8a01d2c_e69f_4138_8bd3_4edddf404753
is encoded by: hsa:10588
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: MTHFS
is: P49914
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c9661282_6788_4678_8323_16c650701926
name: B3GNT3
initial amount: NaN
is: SBO:0000252
is: Q9Y2A9
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:10331

metaR G6Pter
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion

metaR r1626
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR LINKDEG4ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110062#
name: degradation of proteoglycan linkage region, lysosomal
reversible: false
kinetic law: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
type: Reaction

metaM Ser Thr l
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00425
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247

metaM CE2417 m
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: SBO:0000247
is: CHEBI:28387
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: HMDB11123
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_e78c94b3_ab72_4c2e_a837_d74589325e71
is encoded by: hsa:10396
boundary condition: true
is: Q9Y2Q0
initial concentration: NaN
initial amount: NaN
name: ATP8A1
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaR r2133
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM orn c
initial concentration: 1.0
name: Ornithine
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
type: Species
is: CHEBI:0
constant: false
is: HMDB00214
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_9736ef62_9601_4c05_b05b_134c26e13ce9
constant: false
name: DHODH
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1723
is: Q02127

metaR r1627
type: Reaction
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r2020
modifier: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
fast: false
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000

metaR EX c6crn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_cdc0f636_325e_4832_9e61_9b1015303998
is: P52824
constant: false
is encoded by: hsa:1609
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: DGKQ
initial concentration: NaN

metaM asp D e
is: CHEBI:29990
is: HMDB06483
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
name: D-aspartate(1-)

metaM gbside hs e
has only substance units: false
is: SBO:0000247
name: globoside
type: Species
constant: false
is: CHEBI:18259
boundary condition: false
initial amount: NaN
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial concentration: 1.0

metaR r1492
reactant: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Utilized transport
product: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
reversible: false

metaR ACETONEt2m
is: SBO:0000185
reactant: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: acetone mitochondrial transport via proton symport
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_9801f23b_b94d_445b_a744_fdca421593d0
name: ARSB
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:411
is: A8K4A0
has only substance units: false
boundary condition: true

metaM elaid c
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: elaidate
is: CHEBI:30825
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: HMDB00573
initial concentration: 1.0
type: Species
has only substance units: false

metaM dopasf e
is: CHEBI:37946
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB06275
name: dopamine 3-O-sulfate
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: SBO:0000247

metaR r1628
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

metaM frdp c
initial concentration: 1.0
is: SBO:0000247
is: C00448
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:175763
constant: false
name: Farnesyl diphosphate
is: HMDB00961
boundary condition: false

metaR r1090
kinetic law: MODEL1310110062#
fast: false
reversible: false
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
is: SBO:0000185

metaR r2132
type: Reaction
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR DLNLCGCRNt
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110062#
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000

metaM 3hpp m
is: CHEBI:16510
constant: false
boundary condition: false
has only substance units: false
type: Species
name: 3-hydroxypropionate
initial concentration: 1.0
is: HMDB00700
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013

metaR HMGCOARc
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
is described by: ECO:0000134
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e9734231_703a_44e9_9f12_5d9457e85a61
boundary condition: true
is: P56385
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ATP5I
type: Species
is encoded by: hsa:521

http://identifiers.org/biomodels.db/MODEL1310110062#_4422b6e5_6904_4379_8f6c_a3be508a01d3
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: Q96AT9
is encoded by: hsa:6120
has only substance units: false
name: RPE
boundary condition: true
type: Species

metaM glyc3p c
is: C00093
is: CHEBI:57597
type: Species
boundary condition: false
name: Glycerol 3-phosphate
has only substance units: false
is: HMDB00126
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial amount: NaN
constant: false

metaR SEBCOAPET
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM hco3 m
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:17544
is: HMDB00595
initial concentration: 1.0
is: C00288
initial amount: NaN
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
name: Bicarbonate
is: SBO:0000247

metaM 5dpmev x
type: Species
boundary condition: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
is: HMDB01090
name: (R)-5-Diphosphomevalonate
is: CHEBI:15899
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR HEX7
modifier: MODEL1310110062#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: hexokinase (D-fructose:ATP)
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2

http://identifiers.org/biomodels.db/MODEL1310110062#_cdd22c99_f92e_4b5a_a0c0_61ca20bb7b41
is encoded by: hsa:284111
is: SBO:0000252
name: SLC13A5
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q86YT5

metaM fe2 c
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: HMDB00692
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:29033
is: C00023
is: SBO:0000247
name: Fe2+
boundary condition: false
initial concentration: 1.0

metaM orn e
has only substance units: false
initial concentration: 1.0
type: Species
name: Ornithine
boundary condition: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:0
constant: false
is: HMDB00214
is: SBO:0000247
initial amount: NaN
is: C01602

metaR ATP2ter
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
name: AMP/ATP transporter, endoplasmic reticulum

metaM 44mzym r
is: HMDB01286
boundary condition: false
constant: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
name: 14-demethyllanosterol
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:18364
initial concentration: 1.0

metaM dsT antigen g
is: HMDB01440
notes: FORMULA: C36H56N3O26X CHARGE: -2
boundary condition: false
name: disialyl-T antigen
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16497
initial amount: NaN
type: Species

metaR 5OXPROt
fast: false
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110062#
reversible: true
name: Transport of 5-oxoprolinate
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185

metaM 4fumacac c
is: CHEBI:18034
has only substance units: false
is: SBO:0000247
name: 4-fumarylacetoacetate(2-)
initial concentration: 1.0
constant: false
is: HMDB01268
type: Species
initial amount: NaN
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
boundary condition: false

metaR r2131
modifier: MODEL1310110062#
fast: false
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR r1629
is described by: ECO:0000000
product: MODEL1310110062#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r0688
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
fast: false
reversible: true

metaR GLYC3Ptmc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
reactant: MODEL1310110062#
is: SBO:0000185
fast: false
product: MODEL1310110062#
reversible: true
is described by: ECO:0000134
name: glycerol-3-phopshate transport, cytoplasm
kinetic law: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_cf11f3fa_3f4d_44e6_ae41_401483a03fe9
initial concentration: NaN
boundary condition: true
is: E9PH29
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: PRDX3
has only substance units: false
is encoded by: hsa:10935

metaM dcholcoa c
initial amount: NaN
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
has only substance units: false
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaR RE0583C
is described by: ECO:0000000
reversible: true
product: MODEL1310110062#
is: SBO:0000176
name: RE0583
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
kinetic law: MODEL1310110062#
fast: false
type: Reaction

metaM 3hbcoa m
initial amount: NaN
initial concentration: 1.0
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: HMDB01166
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57316

http://identifiers.org/biomodels.db/MODEL1310110062#_b2c6006a_d32d_499a_ac5c_e4b8189a412f
name: PRPS2
initial amount: NaN
is: P11908
constant: false
type: Species
is encoded by: hsa:5634
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM gbside hs g
type: Species
has only substance units: false
name: globoside
constant: false
is: CHEBI:18259
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0

metaR FAOXC10C10OHm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaR r2130
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110062#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110062#

metaM decdicoa c
initial concentration: 1.0
is: HMDB01168
constant: false
initial amount: NaN
is: SBO:0000247
name: decadienoylcoa
has only substance units: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_005b7449_55f3_4bcb_a876_1965ca5dec96
type: Species
name: ALDH3A2
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: P51648
is encoded by: hsa:224
initial concentration: NaN
boundary condition: true

metaM glc D c
is: HMDB00122
name: D-glucose
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:4167
constant: false
has only substance units: false

metaR r1642
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM T4hcinnm m
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: trans-4-coumarate
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
is: CHEBI:12876
constant: false
type: Species
is: HMDB02035

metaR FAOXC101C102m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR DITPtn
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110062#
name: dITP nuclear transport
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
reversible: true

metaR ALAtN1
name: Alanine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110062#
type: Reaction
reversible: true
kinetic law: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
is: SBO:0000185
fast: false
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_c9a70d11_c804_4485_82d8_46712e0201db
name: _AI222095_1_e
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI222095
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_1d20db4d_7cf6_48e3_a826_634bd0330999
type: Species
boundary condition: true
initial concentration: NaN
name: HNMT
initial amount: NaN
has only substance units: false
constant: false
is: P50135
is: SBO:0000252
is encoded by: hsa:3176

metaM duri c
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
type: Species
boundary condition: false
is: C00526
has only substance units: false
is: HMDB00012
constant: false
name: Deoxyuridine
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_be669e31_182f_42d3_b2a7_0a853bcebc98
is: SBO:0000252
type: Species
name: _AA532636_1_m
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AA532636
initial amount: NaN
has only substance units: false

metaR r0668
type: Reaction
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.2.19
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110062#

metaR FAOXC18C18OHm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR ADPT
is: SBO:0000176
kinetic law: MODEL1310110062#
is described by: ECO:0000269
fast: false
product: MODEL1310110062#
name: adenine phosphoribosyltransferase
reactant: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.7
type: Reaction
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
modifier: MODEL1310110062#

metaM 3pg c
boundary condition: false
is: C00197
initial amount: NaN
is: CHEBI:58272
name: 3-Phospho-D-glycerate
is: http://identifiers.org/pubchem.compound/3497
has only substance units: false
initial concentration: 1.0
is: HMDB00807
constant: false
is: SBO:0000247
type: Species

metaR r1641
kinetic law: MODEL1310110062#
is: SBO:0000185
reversible: true
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110062#

metaM 2octpencoa m
initial amount: NaN
has only substance units: false
constant: false
is: HMDB06294
boundary condition: false
type: Species
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
name: 2,6,9,12,15-octadecapentenoylcoa
initial concentration: 1.0
is: SBO:0000247

metaR KYN
type: Reaction
is version of: http://identifiers.org/ec-code/3.7.1.3
fast: false
is described by: ECO:0000269
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8942.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 4 AUTHORS: PMID:9180257 NOTES:NCD
reversible: false
reactant: MODEL1310110062#
name: kynureninase
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_5e765319_d7e5_4eeb_b886_25544d199926
has only substance units: false
is: O75355
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:956
type: Species
boundary condition: true
name: ENTPD3

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110062#
type: Reaction
reversible: false
name: beta-galactosidase, lysosomal
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110062#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_9d4772f6_7b78_4768_b073_0b5078864ed2
initial amount: NaN
is: SBO:0000252
is: P11586
is encoded by: hsa:4522
boundary condition: true
name: MTHFD1
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_f2155b45_e0b6_44d5_8cf2_78a4dd9dcf38
is: Q16720
has only substance units: false
name: ATP2B3
is encoded by: hsa:492
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaM aicar e
is: CHEBI:58475
is: C04677
initial concentration: 1.0
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: HMDB01517
notes: FORMULA: C9H13N4O8P CHARGE: -2
has only substance units: false
initial amount: NaN

metaR r0669
reactant: MODEL1310110062#
reversible: false
type: Reaction
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
fast: false
product: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is described by: ECO:0000000

metaR r1640
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
is described by: ECO:0000000
product: MODEL1310110062#

metaR GCCam
product: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110062#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoylprotein), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110062#_a1620293_c66b_44cf_9b94_75dc2828074f
is encoded by: hsa:9154
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q96PL7
name: SLC28A1
constant: false
initial concentration: NaN
has only substance units: false

metaM inost e
is: CHEBI:17268
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: HMDB00211
has only substance units: false
boundary condition: false
initial amount: NaN

metaM 6a2ohxnt x
constant: false
has only substance units: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
boundary condition: false
initial concentration: 1.0
name: 6-amino-2-oxohexanoic acid
initial amount: NaN
is: HMDB12151
is: CHEBI:17534
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_16b7f6f2_c097_4942_9330_77f47a5bcc2f
initial amount: NaN
initial concentration: NaN
name: SULT1A1
boundary condition: true
has only substance units: false
is encoded by: hsa:6817
constant: false
type: Species
is: SBO:0000252

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM tcynt m
boundary condition: false
is: SBO:0000247
is: CHEBI:18022
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
type: Species
name: thiocyanate

http://identifiers.org/biomodels.db/MODEL1310110062#_f4d93443_7ab7_4313_80b1_d24a3de80218
boundary condition: true
initial amount: NaN
name: PIK3C2B
is: SBO:0000252
type: Species
is: O00750
constant: false
is encoded by: hsa:5287
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_77e73b2a_7c02_4074_8ba5_d34ff3a04545
is: SBO:0000252
constant: false
name: GBA
boundary condition: true
is encoded by: hsa:2629
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: B7Z6S1

metaM glyald c
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
type: Species
is: C00577
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:17378
has only substance units: false
initial concentration: 1.0
name: D-Glyceraldehyde
is: HMDB01051

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaR r0892
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.27
product: MODEL1310110062#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
reactant: MODEL1310110062#
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_5cb4aec0_19e5_419c_bb74_313495b25f7f
boundary condition: true
is encoded by: hsa:AA081045
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: _AA081045_1_e
initial amount: NaN

metaR TETPENT6COAtx
type: Reaction
reversible: true
product: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
fast: false
kinetic law: MODEL1310110062#

metaR AG13T11g
is: SBO:0000176
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaM ksi deg27 l
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
has only substance units: false
is: HMDB00143
constant: false
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 27

http://identifiers.org/biomodels.db/MODEL1310110062#_e10d74d7_93ba_4ad5_be8c_19c1bc609166
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: P36021
is encoded by: hsa:6567
name: SLC16A2
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_fb14ad5c_93a0_4821_92ba_abdacb92d4b4
initial amount: NaN
is: Q9H553
is: SBO:0000252
is encoded by: hsa:85365
name: ALG2
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaM aicar c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
has only substance units: false
is: C04677
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
is: HMDB01517
boundary condition: false
is: CHEBI:58475

metaR GALASE16ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
fast: false
reactant: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_0c4556cd_5cb1_4690_a712_f44785c32751
has only substance units: false
type: Species
is: Q9Y345
boundary condition: true
initial concentration: NaN
name: SLC6A5
initial amount: NaN
is encoded by: hsa:9152
is: SBO:0000252
constant: false

metaR G6PDA
is: SBO:0000176
reactant: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
is version of: http://identifiers.org/ec-code/3.5.99.6
type: Reaction
name: glucosamine-6-phosphate deaminase
reversible: false
is described by: ECO:0000269

metaR r1646
fast: false
reactant: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_59b00ed7_928f_49ed_a28c_82f1fca3d438
initial amount: NaN
name: NDUFA5
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4698
is: Q16718

http://identifiers.org/biomodels.db/MODEL1310110062#_ca74bccc_8553_4312_b09f_c0ecf0802949
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:10327
is: SBO:0000252
name: AKR1A1
constant: false
initial concentration: NaN
has only substance units: false

metaM sphings c
is: HMDB00252
initial amount: NaN
is: CHEBI:57756
boundary condition: false
constant: false
has only substance units: false
name: sphingosine(1+)
is: SBO:0000247
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_9159f77d_18c5_4c02_82ae_1cd8cb2c7af6
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:2880
type: Species
is: SBO:0000252
name: GPX5
is: O75715
boundary condition: true
constant: false

metaR r2126
kinetic law: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000185

metaR PHEtec
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110062#
fast: false
type: Reaction
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
name: L-phenylalanine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (117247.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462,PMID:14624363,PMID:15659399 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110062#_be05eab0_bdbb_4728_8891_b65c254fc807
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
type: Species
is encoded by: hsa:518
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000297

metaR r1791
product: MODEL1310110062#
type: Reaction
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
is described by: ECO:0000000

metaR EX 3ivcrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaM adrn e
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
name: adrenic acid
constant: false
is: HMDB02226
is: CHEBI:53487
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR r1645
reversible: true
product: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_874066ee_fde8_49c6_876d_f779533b1e62
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:4729
has only substance units: false
name: NDUFV2
initial concentration: NaN
type: Species
is: P19404

http://identifiers.org/biomodels.db/MODEL1310110062#_4e0b7dc1_97ad_48bb_accb_853c62bbcc9a
is encoded by: hsa:23428
initial amount: NaN
is: SBO:0000297
name: SLC7A8:SLC3A2
type: Species
has part: Q9UHI5
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaR C12DCACOT
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_3362f770_0348_4077_b5f4_0a5284e9aa19
is encoded by: hsa:4129
boundary condition: true
is: SBO:0000252
name: MAOB
has only substance units: false
is: P27338
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaR r2127
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110062#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110062#

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR GUMTCHOLe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR r1644
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_b7f7b5af_f58f_4d7c_87c9_33af2a76f14a
name: _AI684467_1_m
has only substance units: false
is encoded by: hsa:AI684467
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaM ksi l
is: SBO:0000247
is: CHEBI:57455
initial concentration: 1.0
is: HMDB01354
has only substance units: false
constant: false
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
is: C00445
name: keratan sulfate I
boundary condition: false

metaM glc D e
has only substance units: false
name: D-glucose
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
is: CHEBI:4167
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00122

metaR r2128
kinetic law: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#

metaM duri e
initial amount: NaN
type: Species
is: CHEBI:16450
is: C00526
initial concentration: 1.0
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
boundary condition: false
has only substance units: false
is: HMDB00012
name: Deoxyuridine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_7a5dac1b_3fe5_471c_85a1_f660388c435e
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4714
initial amount: NaN
is: O95169
is: SBO:0000252
name: NDUFB8
initial concentration: NaN
constant: false

metaR r0400
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.4
reversible: true
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:

metaR r1643
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: true

metaR EX 3octdeccrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_2dd5307f_d753_43fc_8078_13123041c375
name: ATP1A4:ATP1B1
is: SBO:0000297
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
has part: Q13733
is encoded by: hsa:480
initial amount: NaN
constant: false

metaR r2129
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110062#
reactant: MODEL1310110062#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#

metaM c8crn c
is: C02838
constant: false
is: HMDB00791
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: octanoyl carnitine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H29NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110062#_ead73f17_c8c2_4f9a_82db_316a8d5c5aef
has only substance units: false
is encoded by: hsa:3631
type: Species
is: SBO:0000252
is: Q96PE3
boundary condition: true
constant: false
name: INPP4A
initial concentration: NaN
initial amount: NaN

metaM ksii core2 pre4 g
boundary condition: false
notes: FORMULA: C53H86N4O38X CHARGE: -1
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 4
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00175
type: Species
constant: false
is: CHEBI:58053
is: C00130

metaR FAOXC225m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM fe2 m
has only substance units: false
type: Species
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
boundary condition: false
is: C00023
initial concentration: 1.0
is: CHEBI:29033
is: SBO:0000247
is: HMDB00692
name: Fe2+
initial amount: NaN
constant: false

metaM apoC Lys m
notes: FORMULA: C6H13N2OX CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Apocarboxylase (Lys residue)
has only substance units: false
is: HMDB00182
constant: false
is: CHEBI:32551
boundary condition: false
type: Species

metaR TSULt4 3
reversible: true
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
name: thiosulfate transport via sodium symport
is: SBO:0000185
product: MODEL1310110062#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction

metaR CITtam
is: SBO:0000185
type: Reaction
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
name: citrate transport, mitochondrial
fast: false
is described by: ECO:0000269
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_3f19724d_34f5_4209_9bdb_974532683488
has only substance units: false
is: SBO:0000297
initial concentration: NaN
has part: P15531
type: Species
constant: false
is encoded by: hsa:4830
initial amount: NaN
is encoded by: hsa:4831
has part: P22392
name: NME1:NME2
boundary condition: true

metaR DOLPH Ler
reversible: false
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
product: MODEL1310110062#
name: Dolichol-phosphate phosphohydrolase, human (liver)
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_9ad2bcb3_21e6_463b_909f_faf14aabfae3
has only substance units: false
initial amount: NaN
is encoded by: hsa:29925
name: GMPPB
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e352e9b3_5262_4bb2_9458_e9e009f2f80a
has only substance units: false
is encoded by: hsa:AV717590
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: _AV717590_1_c
type: Species
is: SBO:0000252

metaM cs e l
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB02183
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
has only substance units: false
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
is: CHEBI:36005
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_61ec2563_5a59_424c_99b5_8b5e62bb87cf
has only substance units: false
name: PPCDC
is: SBO:0000252
is encoded by: hsa:60490
constant: false
is: Q96CD2
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR GALASE8ly
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110062#
is: SBO:0000176
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction

metaM glyald m
is: HMDB01051
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
has only substance units: false
boundary condition: false
name: D-glyceraldehyde
initial concentration: 1.0
is: CHEBI:17378
initial amount: NaN
constant: false
type: Species

metaR PNTEH
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110062#
name: Hydrolase Class ( RXN R02973)
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
reversible: false

metaR FAOXC163C164Gm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaM c8crn e
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H29NO4 CHARGE: 0
constant: false
name: octanoyl carnitine
type: Species
has only substance units: false
is: C02838
initial concentration: 1.0
is: HMDB00791

metaR r2193
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000185
reversible: true
product: MODEL1310110062#

metaM ksi g
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
is: HMDB01014
is: CHEBI:57255
has only substance units: false
name: keratan sulfate I
is: SBO:0000247

metaM glyc3p x
is: CHEBI:57597
initial concentration: 1.0
is: HMDB00126
is: SBO:0000247
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
name: Glycerol 3-phosphate

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR CORE6GTg
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is described by: ECO:0000000
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction

metaR 4NPHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
kinetic law: MODEL1310110062#
reversible: true
fast: false
is: SBO:0000185
name: xenobiotic transport
reactant: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110062#

metaR r1078
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110062#
reversible: false
name: Vesicular transport
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_72d83339_883b_460f_8176_63a598befbf6
constant: false
initial amount: NaN
type: Species
is: B4DIA3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6535
name: SLC6A8
boundary condition: true

metaR r2019
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110062#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110062#

metaR B3GNT39g
kinetic law: MODEL1310110062#
reversible: false
product: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false

metaR GGH 10FTHF6GLUe
reactant: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_fd49f322_07d0_40f7_bb57_a53536fa7def
is: Q6P1K9
has only substance units: false
name: PANK2
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:80025
initial concentration: NaN
initial amount: NaN

metaM tdcoa m
has only substance units: false
constant: false
is: C02593
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: CHEBI:57385

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR r0556
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.14.19.1
kinetic law: MODEL1310110062#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is described by: ECO:0000000
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_5d9672d2_25f0_46ed_b425_f80ce93cb3e3
is: SBO:0000252
name: LPGAT1
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: Q92604
initial concentration: NaN
constant: false
is encoded by: hsa:9926

metaM pail3p hs n
boundary condition: false
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58088
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
has only substance units: false

metaR DHCR72r
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.21
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
name: 7-dehydrocholesterol reductase
is described by: ECO:0000269
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ

metaR RE3001M
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.34
name: RE3001
is described by: ECO:0000000
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true

metaM 3pg m
is: SBO:0000247
is: CHEBI:58272
boundary condition: false
constant: false
has only substance units: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: HMDB00807
type: Species
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial concentration: 1.0
initial amount: NaN

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR HOCTDACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_709a6f25_9ff4_4d8f_9f1d_e24e2839f288
name: BCKDHB
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:594
initial concentration: NaN
is: P21953
type: Species

metaM hedepecoa m
is: SBO:0000247
name: 2,4,7,10,13-hexadecapentenoylcoa
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
is: HMDB02288
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_4d576ec5_7022_4784_a1dd_e63343e24ca3
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AA081045
name: _AA081045_1_m
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

metaM mmcoa S m
is: HMDB02310
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
is: CHEBI:57327
constant: false
boundary condition: false
has only substance units: false
name: (S)-methylmalonyl-CoA(5-)
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_336916fa_487f_4d1f_b965_b87aa1e871c0
name: IDI2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:91734
type: Species
constant: false
has only substance units: false
is: Q9BXS1
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_bf106cad_ddf9_4687_8234_19807ab0fbbf
initial amount: NaN
is: O75912
type: Species
boundary condition: true
name: DGKI
is encoded by: hsa:9162
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_dc46c7d9_30cc_4535_845b_ca66f0c19c65
is encoded by: hsa:498
initial amount: NaN
boundary condition: true
has part: B4DY56
is: SBO:0000297
type: Species
has only substance units: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN
constant: false

metaM etfrd m
initial amount: NaN
is: HMDB00573
initial concentration: 1.0
name: Electron transfer flavoprotein reduced
boundary condition: false
is: CHEBI:30825
notes: FORMULA: RH2 CHARGE: 0
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaM inost c
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: myo-inositol
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
is: HMDB00211
initial concentration: 1.0
boundary condition: false

metaM glyc R c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: D-glycerate
is: CHEBI:16659
constant: false
type: Species
is: HMDB00139
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

metaR UGLT
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
type: Reaction
reversible: true
is described by: ECO:0000000
name: UDPglucose--hexose-1-phosphate uridylyltransferase
is: SBO:0000176
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_62c7a0c3_7bb5_4bc3_88a5_12d2f747a07a
initial concentration: NaN
is: SBO:0000252
type: Species
name: ENTPD8
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:377841
has only substance units: false
is: Q5MY95

http://identifiers.org/biomodels.db/MODEL1310110062#_7e96496e_01f3_41d5_a7dc_89f1868a5e5e
initial amount: NaN
name: PYCR2
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: Q96C36
is encoded by: hsa:29920
boundary condition: true
type: Species

metaR ACALDt
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
name: acetaldehyde reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_11689dd0_ebe4_496c_92da_4be869d04e21
boundary condition: true
is: SBO:0000252
name: SLC2A9
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:56606
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_d9610e75_c012_43ea_9bb1_3a1073fd87d5
initial concentration: NaN
name: ACADVL
is: P49748
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:37
is: SBO:0000252
has only substance units: false
type: Species

metaR HIVCRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaR EX 3deccrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaM ksi deg29 l
is: CHEBI:12936
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 29
initial concentration: 1.0
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: HMDB00143
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_712ca504_5ab3_43ac_859c_fd5e11eeb129
has only substance units: false
name: UGCG
initial concentration: NaN
boundary condition: true
is: Q16739
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7357
type: Species
constant: false

metaR G14T15g
fast: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e3eedc8c_7cdb_47d6_951a_c6bd536e809a
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: PIGM
is encoded by: hsa:93183
constant: false
is: SBO:0000252
is: Q9H3S5

metaR DM atp c
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110062#
type: Reaction
is described by: ECO:0000134
name: DM_atp(c)

http://identifiers.org/biomodels.db/MODEL1310110062#_49c0cda8_d921_422b_a692_5e4af116a9c3
type: Species
is encoded by: hsa:79695
is: Q8IXK2
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GALNT12
initial concentration: NaN
boundary condition: true

metaM Tn antigen l
is: C04383
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
is: SBO:0000247
initial amount: NaN

metaR HDCEAtr
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reactant: MODEL1310110062#
is described by: ECO:0000000

metaR FAOXC80
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
reversible: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110062#
name: Beta oxidation of med/long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110062#_6d55d7cb_5c40_4543_8d02_b50a4831afe2
type: Species
initial concentration: NaN
is encoded by: hsa:23530
name: NNT
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaR NACHEXA9ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
fast: false
reversible: false

metaM emgacpail hs r
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H74N2O22P2FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
has only substance units: false
boundary condition: false
name: phosphoethanolaminyl-mannosyl-glucosylaminyl-acylphosphatidylinositol (H5)
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_609e3199_8527_49a0_9a16_293458486344
type: Species
is: Q9ULC5
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ACSL5
is encoded by: hsa:51703
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_34f0b88a_0160_4e54_ba81_a33781a08bdd
type: Species
is: Q99808
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2030
name: SLC29A1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_4d929459_c155_4ec0_ac0c_2b05bf0fded8
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: O95573
name: ACSL3
is encoded by: hsa:2181
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_ac2543e5_7cfa_488c_a313_26b96523d152
is encoded by: hsa:4967
has only substance units: false
is encoded by: hsa:1743
name: DLD:DLST:OGDH:PDHX
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1738
has part: Q02218
constant: false
has part: P36957
is encoded by: hsa:8050
initial amount: NaN
is: SBO:0000297
has part: P09622
has part: O00330
type: Species

metaR r0552
is: SBO:0000176
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
fast: false
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_27be2bd9_d0a3_4485_aa79_fc5fdd975469
is encoded by: hsa:10654
is: Q6FGV9
name: PMVK
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR PPPGOm
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
name: protoporphyrinogen oxidase, mitochondrial
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.3.3.4
product: MODEL1310110062#
reversible: false
is described by: ECO:0000304

metaR ADMDC
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
type: Reaction
name: adenosylmethionine decarboxylase
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.50
is: SBO:0000176
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_84ac1ccb_9703_4098_89d9_f7ea4f121983
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: E9PB82
type: Species
boundary condition: true
name: HSD17B4
is encoded by: hsa:3295
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_d9441540_67e7_40c3_a03a_97d6c88bf738
is: P22413
initial concentration: NaN
is encoded by: hsa:5167
initial amount: NaN
boundary condition: true
name: ENPP1
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaR C80CPT1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaR GLYtm
type: Reaction
name: glycine passive transport to mitochondria
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
reactant: MODEL1310110062#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b4b09802_63ce_47c8_964c_4ea91b2082b7
initial amount: NaN
is: Q96RQ3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56922
constant: false
name: MCCC1
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_81274671_dd23_4ec3_979a_f1e86747ed49
has only substance units: false
constant: false
is encoded by: hsa:5313
is: P30613
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: PKLR

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR r0553
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000

metaM ksi e
constant: false
has only substance units: false
name: keratan sulfate I
is: HMDB00211
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:17268
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM 4ppcys c
is: HMDB01117
type: Species
is: C04352
has only substance units: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:59458

metaR r0779
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110062#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110062#
type: Reaction

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR r0999
name: Facilitated diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaR UMPK5
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
name: UMP kinase (dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#

metaR SERGLYexR
fast: false
is described by: ECO:0000304
name: L-Serine/Glycine reversible exchange
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110062#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110062#

metaR RE1709C
is: SBO:0000176
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709

metaM dec47dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: 4,7-decadienoylcoa

metaR CYTK4n
is: SBO:0000176
kinetic law: MODEL1310110062#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,GTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_31f9e3f8_b1c7_4693_83b6_3ad553097874
is: Q9BRC7
name: PLCD4
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84812
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_6bcf8065_6fc2_48ef_8f79_ce0734736e50
initial amount: NaN
name: ECH1
constant: false
is encoded by: hsa:1891
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q13011

metaM c3dc e
type: Species
is: HMDB02095
boundary condition: false
name: malonyl carnitine
is: SBO:0000247
notes: FORMULA: C10H16NO6 CHARGE: -1
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

metaR TYRt
name: L-tyrosine transport
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110062#
fast: false

metaM ksi deg14 l
is: SBO:0000247
name: keratan sulfate I, degradation product 14
initial amount: NaN
constant: false
is: CHEBI:12936
type: Species
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c9acd1ba_7bde_4cff_aab6_368a300302a5
name: SLC2A14
is: Q8TDB8
boundary condition: true
is encoded by: hsa:144195
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaR FRDPtc
fast: false
type: Reaction
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
reversible: true

metaR r0998
fast: false
name: Facilitated diffusion
is: SBO:0000185
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_e3f19b21_4a09_4b7d_928d_f25012569100
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6578
has only substance units: false
constant: false
name: SLCO2A1
initial amount: NaN
type: Species
is: SBO:0000252
is: Q92959

http://identifiers.org/biomodels.db/MODEL1310110062#_6ce5754a_bc4c_44ab_99bb_7f37216734a9
is: SBO:0000252
name: BAAT
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:570
has only substance units: false
is: Q14032
boundary condition: true
initial concentration: NaN

metaR UMPK6
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110062#
name: UMP kinase (dCTP)
reactant: MODEL1310110062#

metaM Tn antigen g
has only substance units: false
initial concentration: 1.0
name: Tn antigen
is: C04383
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_a19c90cd_f99c_44b6_8d9f_c868756e29bc
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _100128062_1_m
initial concentration: NaN
is encoded by: hsa:100128062
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_6a79b94d_ff74_4b15_8596_481318eed924
has only substance units: false
initial amount: NaN
name: SLC33A1
is: O00400
is encoded by: hsa:9197
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR r0784
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
product: MODEL1310110062#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
modifier: MODEL1310110062#

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_49f4bd27_96d2_4202_912c_983e64006e0a
initial concentration: NaN
is encoded by: hsa:5286
type: Species
initial amount: NaN
has only substance units: false
name: PIK3C2A
is: O00443
boundary condition: true
constant: false
is: SBO:0000252

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_7a238e3d_4f9c_435a_9490_efe9d51bed2c
is: SBO:0000252
type: Species
is encoded by: hsa:205
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: AK4
constant: false

metaR DALAt2r
is described by: ECO:0000304
modifier: MODEL1310110062#
reversible: true
product: MODEL1310110062#
name: D-alanine transport via proton symport
reactant: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
type: Reaction
fast: false
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_cad45366_f1a6_4c0c_964a_ed295d5498d3
is encoded by: hsa:53
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: ACP2
type: Species
is: E9PCI1

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM stcoa m
constant: false
initial concentration: 1.0
is: CHEBI:57394
is: SBO:0000247
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
has only substance units: false
name: Stearoyl-CoA (n-C18:0CoA)
type: Species
is: C00412
is: HMDB01114
initial amount: NaN
boundary condition: false

metaM CE1939 e
is: CHEBI:36781
is: SBO:0000247
name: spermidine monoaldehyde 1
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r0787
fast: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
type: Reaction
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR C6CRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

metaM gtp e
is: SBO:0000247
name: GTP(4-)
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
is: HMDB01273
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_4cf3f448_af03_4557_b9e9_57253212b844
is: A0S0A7
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:4846
boundary condition: true
is: SBO:0000252
name: NOS3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9b04315b_7425_453b_bc03_d46105d8f05c
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: _AI620219_1_m
is encoded by: hsa:AI620219
constant: false
has only substance units: false
initial concentration: NaN

metaR PRPPS
name: phosphoribosylpyrophosphate synthetase
product: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.6.1
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaM creat c
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16919
initial amount: NaN
name: creatine
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false
is: HMDB00064

http://identifiers.org/biomodels.db/MODEL1310110062#_fe3c1c98_8677_4c86_9e0a_e44126b082e2
boundary condition: true
is encoded by: hsa:10587
name: TXNRD2
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR 34DHXMANDACOX
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
reversible: false
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110062#

metaR GTHRDt
name: Glutathione transport into mitochondria
reversible: true
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reactant: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction

metaR UMPK2
is described by: ECO:0000269
kinetic law: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
name: UMP kinase (CTP)
product: MODEL1310110062#
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR UMPK4
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (GTP)
is: SBO:0000176
reversible: true
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#

metaR DOLGLCP Lter
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
reactant: MODEL1310110062#
fast: false
is: SBO:0000185
product: MODEL1310110062#

metaM dcmp c
is: HMDB01202
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57566
is: C00239
name: dCMP
constant: false
initial amount: NaN
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaM h2o2 m
has only substance units: false
is: C00027
constant: false
initial concentration: 1.0
is: CHEBI:16240
is: SBO:0000247
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
type: Species
name: Hydrogen peroxide
is: HMDB03125

metaM ksi deg11 l
name: keratan sulfate I, degradation product 11
is: SBO:0000247
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:12936
boundary condition: false

metaM man c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
initial amount: NaN
name: D-Mannose
is: CHEBI:16024
is: HMDB00169
is: SBO:0000247
has only substance units: false
is: C00159
constant: false
boundary condition: false
initial concentration: 1.0

metaM 5oxpro e
constant: false
name: 5-oxoprolinate
is: HMDB00267
is: CHEBI:57606
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR UMPK3
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110062#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: true
name: UMP kinase (UTP)
fast: false
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_94311665_5b0a_4e91_8c80_930e96f981a5
is: SBO:0000297
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
type: Species
has part: Q6IB54
initial concentration: NaN

metaM 4ppcys m
has only substance units: false
is: HMDB01117
is: CHEBI:59458
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaR GPIAT
reactant: MODEL1310110062#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
name: glucosaminylphosphatidyl inositol acetyltransferase
reversible: false
kinetic law: MODEL1310110062#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_56a8b226_c94f_48bd_aa89_a8cebd9b441a
boundary condition: true
is: P00338
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3939
initial concentration: NaN
initial amount: NaN
constant: false
name: LDHA

metaR r0781
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: true
is: SBO:0000176
is described by: ECO:0000000

metaM hom L e
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719
type: Species
name: L-homoserine
is: SBO:0000247
is: CHEBI:15699
initial concentration: 1.0
boundary condition: false

metaR RE3242R
reversible: true
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
name: RE3242
product: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR XYLt
product: MODEL1310110062#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110062#
name: D-xylose reversible transport
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
modifier: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#

metaR 34HPLFM
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: 3-(4-hydroxyphenyl-)lactate formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction

metaM 3hdeccoa c
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
has only substance units: false
name: 3-hydroxyhexadecenoylcoa
initial amount: NaN
boundary condition: false
is: HMDB02014
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR PHYCBOXL
reversible: false
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is described by: ECO:0000212
modifier: MODEL1310110062#
name: L-Phenylalanine carboxy-lyase
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28

metaM dcyt e
is: CHEBI:15698
initial amount: NaN
constant: false
is: HMDB00014
is: SBO:0000247
name: Deoxycytidine
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
is: C00881

metaR r2014
reversible: false
fast: false
product: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
type: Reaction

metaM creat e
is: CHEBI:16919
has only substance units: false
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial concentration: 1.0
constant: false
is: HMDB00064
name: creatine
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR UGLCNACtg
reversible: true
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
name: UDP-GlcNAc Golgi transport via CMP antiport
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reactant: MODEL1310110062#
fast: false
modifier: MODEL1310110062#

metaR DHCR71r
reactant: MODEL1310110062#
is described by: ECO:0000134
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
kinetic law: MODEL1310110062#
type: Reaction
fast: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.1.21
modifier: MODEL1310110062#
name: 7-dehydrocholesterol reductase

http://identifiers.org/biomodels.db/MODEL1310110062#_e28c6f89_c056_4fca_b7ab_cd63a827b7f7
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC2A8
constant: false
boundary condition: true
is encoded by: hsa:29988
has only substance units: false
is: Q9NY64
is: SBO:0000252

metaM dec24dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,4-decadienoylcoa
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01168
initial amount: NaN

metaR r0780
product: MODEL1310110062#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110062#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_831544e8_3096_4ecb_8dc0_ca91029d9735
is: Q6FH11
initial amount: NaN
is encoded by: hsa:3162
has only substance units: false
initial concentration: NaN
constant: false
name: HMOX1
type: Species
is: SBO:0000252
boundary condition: true

metaR r0994
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
name: Facilitated diffusion
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_3e848b61_f7e0_4c9b_bce1_1a249c9aa784
constant: false
is: P55809
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5019
is: SBO:0000252
name: OXCT1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_e869ac89_ab11_40d8_be85_f3815196b011
has only substance units: false
name: IDH2
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3418
is: P48735
initial amount: NaN
boundary condition: true
type: Species

metaR ATPtm
is: SBO:0000185
product: MODEL1310110062#
reversible: false
fast: false
name: ADP/ATP transporter, mitochondrial
kinetic law: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_829d5bb1_8a28_41b9_afb2_8d74cd50908e
boundary condition: true
is encoded by: hsa:9057
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q92536
type: Species
initial amount: NaN
name: SLC7A6

metaR r2013
kinetic law: MODEL1310110062#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
type: Reaction
is: SBO:0000185
product: MODEL1310110062#

metaM dolp L c
initial amount: NaN
is: CHEBI:57683
type: Species
name: dolichyl phosphate(2-)
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
constant: false

metaM 4hexdtricoa m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: 4,7,10-hexadecatrienoylcoa
initial amount: NaN
type: Species
is: HMDB02288

metaM CE5117 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
is: CHEBI:57923
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110062#_374a043e_e6a8_4e4b_9e4f_79c1c41fb711
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1327
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: COX4I1
is: P13073

metaR r0783
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110062#
reversible: true

metaR FAOXC226205m
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110062#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
name: Beta oxidation of long chain fatty acid

metaM hom L c
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
is: HMDB00719
name: L-homoserine
constant: false
type: Species
is: CHEBI:15699
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r0549
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reversible: true
is described by: ECO:0000000
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
product: MODEL1310110062#
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/1.6.5.3

http://identifiers.org/biomodels.db/MODEL1310110062#_0c58219e_3e9c_4292_9b5b_0e5576a7e2ad
has only substance units: false
constant: false
is: SBO:0000252
name: HAL
is encoded by: hsa:3034
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: B4E0V8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_c2b6dae4_4578_4d2d_9088_b30df1ec28b2
name: ATP5C1
initial concentration: NaN
is: Q6I9V2
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:509
type: Species
boundary condition: true

metaM galgluside hs g
is: HMDB00295
constant: false
has only substance units: false
name: galactosyl glucosyl ceramide
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: SBO:0000247
is: CHEBI:58223
initial concentration: 1.0
is: C00015

metaR r2016
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ATPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110062#
name: ATP diffusion in nucleus
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
fast: false
type: Reaction

metaR UDPGALtg
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
reversible: true
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
name: UDP-Gal Golgi transport via CMP antiport
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_48c1a145_9aa3_41ac_a264_5b4dc2498343
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P78356
has only substance units: false
initial amount: NaN
is encoded by: hsa:8396
constant: false
name: PIP4K2B

http://identifiers.org/biomodels.db/MODEL1310110062#_8d391600_edac_40f8_a0b5_65234a26f6a8
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:10993
has only substance units: false
initial concentration: NaN
is: P20132
initial amount: NaN
constant: false
name: SDS

metaM apoC Lys btn m
initial concentration: 1.0
is: HMDB03134
constant: false
initial amount: NaN
is: C05552
notes: FORMULA: C16H27N4O3SX CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: http://identifiers.org/pubchem.compound/7886

metaR r0782
is: SBO:0000176
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_bd888960_b2d4_456e_b6de_f1f605532f7d
initial concentration: NaN
is encoded by: hsa:377841
constant: false
is: SBO:0000252
type: Species
is: Q5MY95
name: ENTPD8
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_be475be8_936a_49f0_b775_ad8d200ca4ff
initial concentration: NaN
type: Species
is encoded by: hsa:23556
name: PIGN
constant: false
is: O95427
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_89c2b700_33a0_4f00_82d2_644b930dbe36
initial concentration: NaN
constant: false
has only substance units: false
name: GPX4
boundary condition: true
is encoded by: hsa:2879
initial amount: NaN
is: SBO:0000252
is: P36969
type: Species

metaR PDE1
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.17
name: 3',5'-cyclic-nucleotide phosphodiesterase
is: SBO:0000176
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
kinetic law: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.4.35
type: Reaction

metaM man g
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
initial concentration: 1.0
is: HMDB00169
has only substance units: false
name: D-mannose
boundary condition: false
is: CHEBI:16024
is: SBO:0000247
constant: false
initial amount: NaN

metaR C3STKR2r
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
name: C-3 sterol keto reductase (zymosterol)
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false

metaM ins c
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:17596
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
is: HMDB00195
type: Species
is: C00294
initial concentration: 1.0
name: Inosine

http://identifiers.org/biomodels.db/MODEL1310110062#_7c39024d_71bd_4f61_8b57_d592203183d3
has part: P14415
initial concentration: NaN
boundary condition: true
is encoded by: hsa:482
has only substance units: false
constant: false
is: SBO:0000297
name: ATP1A3:ATP1B2
type: Species
initial amount: NaN

metaM glyc R m
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: D-glycerate
constant: false
is: CHEBI:16659
type: Species
is: SBO:0000247
is: HMDB00139
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

metaR FAOXC226m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR SO4tl
is described by: ECO:0000269
name: Sulfate transport (lysosome)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#

metaM cs e deg5 l
initial concentration: 1.0
has only substance units: false
is: HMDB00868
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
constant: false
initial amount: NaN
notes: FORMULA: C31H47NO35S3 CHARGE: -4
boundary condition: false
is: CHEBI:57737
is: SBO:0000247

metaR DGULND
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: dehydro-L-gulonate decarboxylase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_46e39ff0_4e52_4bca_8720_70b98a032cde
has only substance units: false
constant: false
type: Species
name: SLC26A6
is encoded by: hsa:65010
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q9NQU1
initial concentration: NaN

metaR r2123
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110062#
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_a1564514_7fad_49da_8f3a_171e6d2584d6
is: SBO:0000252
name: SLC9A1
has only substance units: false
type: Species
constant: false
is encoded by: hsa:6548
initial amount: NaN
initial concentration: NaN
is: P19634
boundary condition: true

metaM 34dhphe e
type: Species
is: SBO:0000247
is: CHEBI:15765
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
initial amount: NaN
is: HMDB00181
initial concentration: 1.0
name: L-dopa
constant: false
boundary condition: false
has only substance units: false

metaR r1637
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_864d9c19_e23f_42f2_849e_f1f72639d826
is: Q8NCL4
is encoded by: hsa:11226
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: GALNT6
initial concentration: NaN

metaM stcoa c
name: Stearoyl-CoA (n-C18:0CoA)
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: HMDB01114
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: C00412
has only substance units: false
constant: false
is: CHEBI:57394
boundary condition: false

metaR 3MOBt2im
is: SBO:0000185
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
product: MODEL1310110062#
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false

metaM retinol c
boundary condition: false
constant: false
is: CHEBI:50211
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
has only substance units: false
initial concentration: 1.0
is: HMDB00305
name: retinol
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_0a3e46b7_b2e7_4a63_91fc_e531e320b54e
initial concentration: NaN
is encoded by: hsa:5277
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PIGA
is: P37287

http://identifiers.org/biomodels.db/MODEL1310110062#_946491f0_b084_4b24_a7d8_359bb2ce3a9d
is: Q99807
initial amount: NaN
name: COQ7
constant: false
is encoded by: hsa:10229
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR r2122
reversible: true
reactant: MODEL1310110062#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM h2o2 x
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:16240
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Hydrogen peroxide
constant: false
is: HMDB03125
is: C00027

metaR r1638
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110062#

metaM gdpmann c
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01163
is: CHEBI:57527
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096

metaR LEUyLAThtc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_788e92e5_0b5a_4bc7_8b16_12ca37de2394
boundary condition: true
is encoded by: hsa:498
has part: P06576
has part: P56381
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
constant: false
has only substance units: false
is encoded by: hsa:509
is: SBO:0000297
initial amount: NaN
has part: P36542
initial concentration: NaN
is encoded by: hsa:513
has part: P30049
has part: A8K092
is encoded by: hsa:514
is encoded by: hsa:506
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_fa73f4c6_52f1_4fc4_af06_93ce870100c1
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:2954
is: SBO:0000252
initial concentration: NaN
name: GSTZ1

metaR AACOAT
name: Acetoacetyl-CoA:acetate CoA-transferase
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.16
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_e580d087_fd2f_4c28_a1a5_febdf141741b
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AA021081
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: _AA021081_1_r

http://identifiers.org/biomodels.db/MODEL1310110062#_245f39ad_d4e4_423e_8eb3_7ae241927e0f
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10317
name: B3GALT5
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR FAOXC163Gm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaR r0885
is: SBO:0000185
reversible: true
reactant: MODEL1310110062#
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
modifier: MODEL1310110062#
product: MODEL1310110062#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7

http://identifiers.org/biomodels.db/MODEL1310110062#_b6297eb5_e5c7_455b_9990_01767ec0ad12
is: P37268
has only substance units: false
name: FDFT1
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2222
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_fb569f76_4985_4ff1_9549_f7ffe06034a5
constant: false
initial concentration: NaN
is: O15466
has only substance units: false
name: ST8SIA5
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:29906

metaM 34dhphe c
is: CHEBI:15765
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: L-dopa
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
is: HMDB00181
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_9b4ceab1_aa31_4032_bcfe_dd15188f9728
has only substance units: false
boundary condition: true
is: Q8WYR1
is: SBO:0000252
is encoded by: hsa:23533
initial amount: NaN
initial concentration: NaN
name: PIK3R5
constant: false
type: Species

metaM 3hdeccoa m
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
name: 3-hydroxyhexadecenoylcoa
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB02288
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM CE5162 r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: trans,cis-2,9-octadecadienoyl-CoA
is: CHEBI:57923

metaM gtp m
initial amount: NaN
is: C00044
is: SBO:0000247
boundary condition: false
is: CHEBI:37565
is: HMDB01273
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
name: GTP
constant: false
initial concentration: 1.0

metaR r2125
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_c289fa5e_d78d_4d1b_aa99_ff04e0a1601a
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: PRPS1L1
type: Species
is encoded by: hsa:221823
has only substance units: false
is: P21108

metaR G3PD1
is version of: http://identifiers.org/ec-code/1.1.1.8
type: Reaction
name: glycerol-3-phosphate dehydrogenase (NAD)
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is described by: ECO:0000269
fast: false
modifier: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_4ae33d8b_c264_4275_8322_ec579673cb5e
is: P19801
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:26
name: ABP1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_5aa9e9a1_1ac4_48a6_9d02_8ff8f4a8f24b
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM arg L m
has only substance units: false
name: L-argininium(1+)
initial amount: NaN
is: CHEBI:32682
type: Species
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247

metaR r1635
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DOLGPP Ler
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
fast: false
is described by: ECO:0000000
product: MODEL1310110062#
reversible: false
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_e7b795a9_21a3_47a5_9dca_9cdd00841182
initial concentration: NaN
is: Q9Y5P4
is: SBO:0000252
initial amount: NaN
name: COL4A3BP
has only substance units: false
constant: false
type: Species
is encoded by: hsa:10087
boundary condition: true

metaM tcynt e
is: SBO:0000247
is: CHEBI:18022
type: Species
constant: false
initial amount: NaN
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
boundary condition: false
is: HMDB01453
initial concentration: 1.0
name: thiocyanate

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_463f662b_13f7_4f86_a916_cefe7bba96fa
boundary condition: true
name: FUT8
is encoded by: hsa:2530
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: Q546E0
initial concentration: NaN

metaR r2124
reactant: MODEL1310110062#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110062#

metaM ksi deg33 l
has only substance units: false
is: HMDB00143
name: keratan sulfate I, degradation product 33
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
type: Species
is: CHEBI:12936

metaM gtp n
type: Species
is: CHEBI:37565
name: GTP(4-)
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01273

metaR RE1709N
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: true
name: RE1709
fast: false
is: SBO:0000176
kinetic law: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000000

metaM man l
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-mannose
is: HMDB00169
initial amount: NaN
is: CHEBI:16024
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_a6fd29ab_5a16_4a50_8f45_6ffb654c5cfc
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: Q9Y666
type: Species
is encoded by: hsa:10723
name: SLC12A7
boundary condition: true
is: SBO:0000252

metaM mi145p c
initial amount: NaN
is: CHEBI:203600
is: HMDB01498
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: SBO:0000247

metaR r1636
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
modifier: MODEL1310110062#

metaM c51crn c
notes: FORMULA: C12H21NO4 CHARGE: 0
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02366
initial concentration: 1.0
name: tiglyl carnitine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_cf81bfc1_867b_4439_9599_c933246df85a
is encoded by: hsa:2348
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: FOLR1
type: Species
constant: false

metaM c5dc e
name: glutaryl carnitine
constant: false
notes: FORMULA: C12H21NO6 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB13130
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b53bfda9_746c_4706_b2e9_b3cf22ccac37
has only substance units: false
name: ESCO1
is encoded by: hsa:114799
type: Species
initial amount: NaN
constant: false
is: Q5FWF5
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR GMAND
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.47
is: SBO:0000176
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
name: GDP-D-mannose dehydratase
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
fast: false
modifier: MODEL1310110062#
reversible: false

metaR HDCAtr
reactant: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110062#
is: SBO:0000185
reversible: true
fast: false
name: fatty acid transport via diffusion

metaM dcmp n
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP(2-)
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57566
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR TAUPAT1c
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_58a55e26_3d45_45e5_8f94_29504a995460
has only substance units: false
is encoded by: hsa:10841
boundary condition: true
constant: false
name: FTCD
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_25aef1e8_6d31_405a_a14d_eb62bd468acb
constant: false
is: SBO:0000252
is: P30519
boundary condition: true
name: HMOX2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3163
initial amount: NaN
type: Species

metaR GALACGLCGALGBSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110062#
type: Reaction
name: galacglcgalgbside hs intracellular transport
kinetic law: MODEL1310110062#
is: SBO:0000185

metaM Rtotal3 e
name: R total 3 position
notes: FORMULA: CO2FULLR3 CHARGE: -1
initial amount: NaN
is: HMDB00244
type: Species
is: CHEBI:3554
is: SBO:0000247
boundary condition: false
is: C00255
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_6ecf9dc2_030f_48bd_ba8b_e6d5417b593a
is: Q16773
has only substance units: false
name: CCBL1
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:883
initial amount: NaN
constant: false
boundary condition: true

metaM pail3p hs c
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
is: CHEBI:58088
constant: false

metaM apoC Lys btn c
initial concentration: 1.0
boundary condition: false
is: CHEBI:32551
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00182
notes: FORMULA: C16H27N4O3SX CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110062#_572246fa_f569_4a17_aede_fb5c5364ea45
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9HBH5
initial amount: NaN
name: RDH14
has only substance units: false
is encoded by: hsa:57665

metaM Rtotal3 c
notes: FORMULA: CO2FULLR3 CHARGE: -1
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB01448
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16189
name: R total 3 position

metaR UGALNACtg
is described by: ECO:0000269
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
type: Reaction
name: UDP-GalNAc Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110062#
fast: false

metaM dcyt n
has only substance units: false
type: Species
is: CHEBI:15698
boundary condition: false
is: SBO:0000247
is: HMDB00014
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
name: 2'-deoxycytidine

http://identifiers.org/biomodels.db/MODEL1310110062#_46549075_366f_4ed7_9861_7f9cc10786fb
initial amount: NaN
type: Species
name: GLB1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2720
is: SBO:0000252
boundary condition: true
is: P16278
constant: false

metaM tcynt c
has only substance units: false
boundary condition: false
is: HMDB01453
initial concentration: 1.0
constant: false
is: SBO:0000247
name: thiocyanate
initial amount: NaN
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species

metaR SERt4
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
is described by: ECO:0000269
reactant: MODEL1310110062#
reversible: false
type: Reaction
name: L-serine via sodium symport
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000185

metaM c3dc c
has only substance units: false
notes: FORMULA: C10H16NO6 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: malonyl carnitine
type: Species
constant: false
boundary condition: false
is: HMDB02095

metaM c5dc c
notes: FORMULA: C12H21NO6 CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB13130
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: glutaryl carnitine

http://identifiers.org/biomodels.db/MODEL1310110062#_77087cab_45d3_44cd_a5c1_9071548d612e
constant: false
is encoded by: hsa:226
has only substance units: false
boundary condition: true
name: ALDOA
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_de493fb4_a484_4389_8242_0d28cbd9036f
is: Q14435
constant: false
boundary condition: true
is encoded by: hsa:2591
type: Species
initial concentration: NaN
has only substance units: false
name: GALNT3
initial amount: NaN
is: SBO:0000252

metaM 2decdicoa m
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
name: 2,7-decadienoylcoa
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247

metaR S6T18g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.17
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.21
modifier: MODEL1310110062#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_87d7d99c_55cf_492c_b07e_67555969fced
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PIGC
type: Species
is encoded by: hsa:5279
has only substance units: false

metaR GALACGLCGALGBSIDEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
fast: false
is: SBO:0000185
name: galacglcgalgbside hs transport
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR r1639
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#

metaM m6mpdol L r
constant: false
is: CHEBI:37635
is: SBO:0000247
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_1a6b5c6c_4dd8_49ed_8314_48f6f14845e5
initial concentration: NaN
name: TXNRD2
initial amount: NaN
boundary condition: true
type: Species
is: Q9NNW7
is encoded by: hsa:10587
is: SBO:0000252
constant: false
has only substance units: false

metaR r2121
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_855ddfbf_51a1_4ec0_9796_f373265d3783
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: Q9Y259
initial amount: NaN
is: SBO:0000252
name: CHKB
is encoded by: hsa:1120

http://identifiers.org/biomodels.db/MODEL1310110062#_0154bdd7_30f2_43cb_b388_3196259e4023
name: PDE3B
is encoded by: hsa:5140
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q13370

metaM CE2418 m
is: HMDB11123
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:28387
constant: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
boundary condition: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA

metaM dgsn c
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00330
name: Deoxyguanosine
is: CHEBI:17172
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
has only substance units: false

metaR ATPtx
kinetic law: MODEL1310110062#
is: SBO:0000185
reversible: true
name: ATP transporter, peroxisomal
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaR ADNt
reactant: MODEL1310110062#
name: adenosine facilated transport in cytosol
modifier: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

metaM dlnlcg c
type: Species
name: dihomo-gamma-linolenic acid (n-6)
is: CHEBI:53486
is: HMDB02925
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-

metaR r2120
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaM bhb c
is: HMDB00011
initial amount: NaN
name: (R)-3-hydroxybutyrate
type: Species
is: SBO:0000247
is: CHEBI:10983
boundary condition: false
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_3b4c9c8b_e335_4fbe_b306_7b3842b9c22c
has only substance units: false
is encoded by: hsa:AI222095
name: _AI222095_1_m
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR r0392
fast: false
reactant: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
reversible: true
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110062#_073fc993_ae39_4c3f_bf78_091fc440b7c0
has only substance units: false
constant: false
is encoded by: hsa:204
initial amount: NaN
name: AK2
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR FAOXC161802m
is: SBO:0000176
reversible: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
name: Beta oxidation fatty acid
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_636fd5c5_030c_4e80_9177_183aa1631754
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11181
initial amount: NaN
constant: false
name: TREH
type: Species
is: O43280
boundary condition: true
initial concentration: NaN

metaR RE2814M
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
type: Reaction
name: RE2814
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_9210bb0c_02e4_4fa9_ab6e_899f902f644d
constant: false
is: SBO:0000252
is encoded by: hsa:771
initial concentration: NaN
name: CA12
boundary condition: true
has only substance units: false
is: O43570
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_153d9932_3438_4c66_8bc8_93385e401274
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110062#_08361fa2_010d_42a7_ab33_c6615919999c
is: P47989
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: XDH
is encoded by: hsa:7498
initial concentration: NaN

metaR RE3218C
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110062#
name: RE3218
is version of: http://identifiers.org/ec-code/3.1.6.2
product: MODEL1310110062#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
modifier: MODEL1310110062#

metaR FACOAL244 1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
name: fatty-acid--CoA ligase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR r1656
product: MODEL1310110062#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110062#
is: SBO:0000185
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction

metaM pi c
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00009
is: SBO:0000247
is: CHEBI:43474
name: hydrogenphosphate
is: HMDB00973
constant: false
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2

metaR r0393
reversible: false
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction

metaR DIDPtn
is described by: ECO:0000000
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: true
is: SBO:0000185
name: dIDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01232
is: CHEBI:57917
has only substance units: false
is: SBO:0000247
type: Species
name: 4-nitrophenolate

metaR EX c81crn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_14f60ad6_beef_4ad3_91ab_e3daf23f39f0
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5295
initial concentration: NaN
boundary condition: true
constant: false
is: E7EX19
initial amount: NaN
name: PIK3R1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_e67ce27f_39b8_4b5c_84ad_722eda85e03b
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: BDH1
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:622

metaR G6PDH2rer
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.47
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
reversible: true
is: SBO:0000176
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000269

metaM hdcea e
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
name: Hexadecenoate (n-C16:1)
is: CHEBI:32372
is: HMDB03229
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_5d5f1f28_3306_41ec_af62_d665c6189946
initial amount: NaN
type: Species
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: P37287
constant: false
is encoded by: hsa:5277
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8818

http://identifiers.org/biomodels.db/MODEL1310110062#_9a65ddc9_0d85_471d_ab38_1676399e86bc
has only substance units: false
name: GCK
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2645
is: SBO:0000252
type: Species

metaM Rtotal c
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: CO2FULLR CHARGE: -1
name: R total
is: HMDB01448
initial concentration: 1.0
boundary condition: false
is: CHEBI:16189

metaM fru c
initial amount: NaN
is: CHEBI:15824
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
name: D-Fructose
is: HMDB00660
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00095
boundary condition: false

metaM gmp e
name: GMP(3-)
initial amount: NaN
initial concentration: 1.0
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: CHEBI:58115
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_40045487_8c22_41c6_8af1_a35b0030e740
name: _F23536_1_m
initial amount: NaN
type: Species
is encoded by: hsa:F23536
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaM ksi pre8 g
initial concentration: 1.0
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 8
boundary condition: false
initial amount: NaN
constant: false

metaR r1655
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_340749f0_1d25_4582_a38f_b3bfd821850e
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q16222
name: UAP1
is encoded by: hsa:6675
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaR r0394
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
reactant: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4

metaM hexdicoa x
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
name: hexadecanedioylcoa
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
boundary condition: false
is: C05258
type: Species
is: HMDB03932

metaM bhb e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:10983
is: HMDB00011

http://identifiers.org/biomodels.db/MODEL1310110062#_eaae575b_0246_4da8_9891_c99f325b2f33
is: SBO:0000252
name: OGDH
constant: false
is encoded by: hsa:4967
has only substance units: false
type: Species
is: B4E3E9
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR ETFQO
reactant: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.5.1
fast: false
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
reversible: false
modifier: MODEL1310110062#
is described by: ECO:0000000
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176

metaM dlnlcg e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false
is: CHEBI:53486
constant: false
name: dihomo-gamma-linolenic acid (n-6)
boundary condition: false
is: HMDB02925

metaM thymd e
is: C00214
initial concentration: 1.0
is: HMDB00273
is: CHEBI:17748
type: Species
name: Thymidine
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

metaR PAPStg
type: Reaction
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
name: 3'-Phosphoadenylyl sufate Golgi transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000269
product: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
reactant: MODEL1310110062#

metaM ksii core2 deg2 l
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 2
boundary condition: false
type: Species
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936

metaR r1658
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_6e7874f5_d86d_4c3c_9e75_45f51c652fc5
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:4126
initial amount: NaN
is: O00462
initial concentration: NaN
name: MANBA

http://identifiers.org/biomodels.db/MODEL1310110062#_6438dd4e_4647_499f_82f3_bb582768f8fa
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC35A2
has only substance units: false
type: Species
is encoded by: hsa:7355
is: P78381

metaR ASCBt
is: SBO:0000185
kinetic law: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
product: MODEL1310110062#
type: Reaction
fast: false
name: L-ascorbate transport via facilitated diffusion
is described by: ECO:0000000
reactant: MODEL1310110062#

metaR FUT17g
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
fast: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
type: Reaction
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110062#
product: MODEL1310110062#

metaR r0881
is: SBO:0000185
name: Active transport
reversible: false
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false

metaR EX CE1940 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine monoaldehyde 2 exchange
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM 4nph c
initial concentration: 1.0
constant: false
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01232
name: 4-nitrophenolate
has only substance units: false

metaM 3hdcoa c
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
name: (S)-3-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: HMDB13325

metaM cmpacna c
boundary condition: false
is: HMDB01176
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57812
constant: false
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
type: Species

metaM pi e
has only substance units: false
initial amount: NaN
type: Species
is: C00009
boundary condition: false
is: SBO:0000247
is: CHEBI:43474
initial concentration: 1.0
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110062#_7168f566_2edb_49ab_8245_3e3f3a4441ad
initial amount: NaN
is encoded by: hsa:9651
type: Species
name: PLCH2
has only substance units: false
is: O75038
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR TSTSTERONEt
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000269
name: Testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
reversible: true
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000185

metaM HC00229 e
constant: false
boundary condition: false
is: CHEBI:28189
name: Isomaltose
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_b9f44127_2798_4a1b_86a9_594006ad8237
initial concentration: NaN
is encoded by: hsa:2954
name: GSTZ1
is: O43708
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM dcsptn1coa m
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205483
constant: false
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
type: Species
is: HMDB06513
is: SBO:0000247
initial concentration: 1.0
is: C16173

metaM fru e
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
name: D-Fructose
is: SBO:0000247
has only substance units: false
is: CHEBI:15824
type: Species
is: HMDB00660
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C00095
constant: false

metaR r1657
fast: false
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM gmp g
is: SBO:0000247
name: GMP(3-)
type: Species
is: HMDB01397
initial concentration: 1.0
is: CHEBI:58115
boundary condition: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
constant: false
initial amount: NaN

metaM no c
constant: false
is: C00533
type: Species
name: Nitric oxide
is: SBO:0000247
initial amount: NaN
is: CHEBI:16480
has only substance units: false
is: HMDB03378
initial concentration: 1.0
boundary condition: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533

http://identifiers.org/biomodels.db/MODEL1310110062#_80467cfe_b996_49cc_9f7f_953c25ea97e0
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79837
has only substance units: false
is: B3KQV3
initial concentration: NaN
name: PIP4K2C
initial amount: NaN
type: Species

metaR r0410
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110062#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000176
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19

metaM 3octdeccrn e
has only substance units: false
is: HMDB13336
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 3-hydroxyoctadecanoyl carnitine
type: Species
constant: false
notes: FORMULA: C25H49NO5 CHARGE: 0
boundary condition: false

metaM hyptaur c
is: CHEBI:16668
initial amount: NaN
name: Hypotaurine
is: HMDB00965
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_1db96c33_4156_4086_abd5_ac2e60f038f2
is: P51178
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: PLCD1
is encoded by: hsa:5333
constant: false

metaM thymd c
is: SBO:0000247
is: CHEBI:17748
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: HMDB00273
is: C00214
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
name: Thymidine
initial amount: NaN

metaM ksi pre34 g
constant: false
has only substance units: false
boundary condition: false
is: C00130
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 34
type: Species
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: HMDB00175
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110062#_fde741c5_39d2_401c_bab8_65440c07e77c
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR r1652
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_7c99cce7_d326_4b59_af5c_97ec7d8dbf48
type: Species
initial concentration: NaN
is encoded by: hsa:80339
constant: false
is: SBO:0000252
is: Q9NST1
name: PNPLA3
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_705ec9d0_9830_4604_8785_7716aeaf8795
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9123
constant: false
name: SLC16A3
type: Species
is: O15427
initial concentration: NaN

metaM fum c
is: HMDB00134
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
is: CHEBI:29806
constant: false
boundary condition: false
name: Fumarate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00122
initial amount: NaN

metaR GLYt7 311 r
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
reversible: true
product: MODEL1310110062#
is described by: ECO:0000006
name: glycine reversible transport via sodium and chloride symport (3:1:1)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_8e160bcc_dde2_440a_9a84_9faf306c70c7
name: PGAP1
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:80055
is: Q75T13
initial amount: NaN
has only substance units: false

metaR G16MT L
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110062#
fast: false
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
product: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110062#

metaM pi g
is: HMDB00973
initial amount: NaN
boundary condition: false
is: CHEBI:43474
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_e01361ec_b03d_4b84_9041_a1203fb7d7de
initial concentration: NaN
is: P28330
boundary condition: true
type: Species
name: ACADL
is encoded by: hsa:33
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_8364dc62_94b4_4f06_b598_8375441da8ed
constant: false
is encoded by: hsa:498
is: B4DY56
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ATP5A1
has only substance units: false

metaR r1651
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
reversible: true

metaM no e
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
is: HMDB03378
name: Nitric oxide
is: SBO:0000247
is: CHEBI:16480
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false

metaM ksii core4 pre8 g
is: CHEBI:58053
constant: false
boundary condition: false
is: C00130
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00175
has only substance units: false
notes: FORMULA: C83H134N7O61SX CHARGE: -2

metaR GLUDxm
name: glutamate dehydrogenase (NAD) (mitochondrial)
is described by: ECO:0000269
modifier: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.1.3
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110062#
fast: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_1612282c_5e3d_4263_ae10_bfeea3d706f6
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:513
initial concentration: NaN
is: P30049
constant: false
initial amount: NaN
boundary condition: true
name: ATP5D

metaM 3octdeccrn c
initial concentration: 1.0
is: SBO:0000247
is: HMDB13336
notes: FORMULA: C25H49NO5 CHARGE: 0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
name: 3-hydroxyoctadecanoyl carnitine

metaR EX c3dc
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR PAIL45P HStn
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110062#_3bc375a0_d940_452e_85da_0fdefeb348b6
is: SBO:0000252
name: _AI440329_1_r
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI440329

metaR r0390
reversible: true
kinetic law: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110062#
fast: false
type: Reaction
reactant: MODEL1310110062#

metaR r1654
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#

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is encoded by: hsa:51292
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: GMPR2
boundary condition: true

metaR r0655
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:

metaM glx m
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN
is: HMDB00119
is: SBO:0000247
is: CHEBI:36655
name: glyoxylate

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type: Species
is: P27708
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: CAD
is encoded by: hsa:790
boundary condition: true

metaM CE2421 m
type: Species
is: CHEBI:16301
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: SBO:0000247
is: HMDB02786
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
constant: false

metaM sarcs m
constant: false
is: CHEBI:15611
initial concentration: 1.0
is: HMDB00271
boundary condition: false
type: Species
is: C00213
has only substance units: false
is: SBO:0000247
name: Sarcosine
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
initial amount: NaN

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type: Species
initial concentration: NaN
is: Q5SYN6
constant: false
boundary condition: true
is encoded by: hsa:6581
name: SLC22A3
initial amount: NaN
is: SBO:0000252
has only substance units: false

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has only substance units: false
initial amount: NaN
is encoded by: hsa:AA419122
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: _AA419122_1_c

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initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:BG035985
name: _BG035985_1_c

http://identifiers.org/biomodels.db/MODEL1310110062#_c6cb697a_176a_4920_a65c_5c10ce282851
is: P04062
boundary condition: true
is encoded by: hsa:2629
type: Species
name: GBA
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaR r0391
reversible: true
kinetic law: MODEL1310110062#
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
reactant: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_11af56e7_9548_484f_8edc_f8aaa9e97baf
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ST20
is: Q9HBF5
is encoded by: hsa:400410
is: SBO:0000252
type: Species
boundary condition: true

metaR r1653
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110062#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM gmp c
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
type: Species
is: HMDB01397
initial amount: NaN
name: GMP
is: CHEBI:58115
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: C00144
initial concentration: 1.0

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constant: false
is: P22033
is encoded by: hsa:4594
initial amount: NaN
initial concentration: NaN
name: MUT
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR FAOXTC162TC142m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

metaR 3MLDAt
reactant: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
fast: false
name: 3MLDA extracellular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
kinetic law: MODEL1310110062#
type: Reaction
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_474144e4_eec6_4f71_a091_27a1e2569b33
boundary condition: true
initial concentration: NaN
name: SDHD
type: Species
has only substance units: false
is: O14521
initial amount: NaN
is encoded by: hsa:6392
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_fafee99b_6225_494f_9c0b_1a0e50322469
initial concentration: NaN
is: P22680
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:1581
name: CYP7A1
constant: false

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type: Species
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PDE8A
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5151

metaR r1925
modifier: MODEL1310110062#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110062#

metaR GALASE3ly
reactant: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
reversible: false
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction

metaM Rtotal2 e
is: CHEBI:3554
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00244
name: R total 2 position
is: SBO:0000247
constant: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: C00255
initial concentration: 1.0
has only substance units: false

metaR PYDXNK
is version of: http://identifiers.org/ec-code/2.7.1.35
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110062#
type: Reaction
name: pyridoxine kinase
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaM crvnc e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:36005
is: HMDB02183
has only substance units: false
name: cervonic acid, C22:6 n-3

http://identifiers.org/biomodels.db/MODEL1310110062#_7079dbe7_277c_4050_916f_80603a09b31a
is: SBO:0000252
boundary condition: true
name: ODC1
is encoded by: hsa:4953
initial concentration: NaN
is: P11926
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_fb9341f0_a43f_4bdd_8d07_fa4c2d196927
has part: E9KL44
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:3032
is: SBO:0000297
has part: P55084
is encoded by: hsa:3030
name: HADHA:HADHB
initial amount: NaN

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_f44e33bd_2b7d_4c35_bf77_6379741a81b1
name: BCKDHA
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:593
is: B4DP47
initial concentration: NaN
boundary condition: true

metaM pi l
initial concentration: 1.0
is: CHEBI:43474
type: Species
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
boundary condition: false
is: HMDB00973
constant: false
is: SBO:0000247
has only substance units: false

metaR FAOXC2031836m
modifier: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110062#

metaR UMPK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110062#
reversible: true
is described by: ECO:0000269
name: UMP kinase (dGTP)
kinetic law: MODEL1310110062#
type: Reaction
fast: false

metaR r1924
is described by: ECO:0000000
fast: false
reversible: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaM dcsptn1coa c
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN
is: C16173
type: Species
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1

metaM cs e deg6 l
initial concentration: 1.0
is: SBO:0000247
is: HMDB01354
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: CHEBI:57455
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
notes: FORMULA: C31H48NO32S2 CHARGE: -3

metaM subeac x
notes: FORMULA: C8H12O4 CHARGE: -2
type: Species
is: HMDB00893
name: suberic acid
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR ALAR
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000212
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110062#
type: Reaction
fast: false
name: alanine racemase

metaM ile L e
initial concentration: 1.0
name: L-isoleucine
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: HMDB00172
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
type: Species
is: CHEBI:17191

http://identifiers.org/biomodels.db/MODEL1310110062#_34b56ea7_ee47_4de6_b7a5_1d49bdaee4f7
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: O95395
name: GCNT3
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:9245

metaR CTPtn
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
name: CTP diffusion in nucleus
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_9b8e81d2_14d9_4f9f_ad50_3f4f394060a4
initial concentration: NaN
is: O43505
is: SBO:0000252
boundary condition: true
name: B3GNT1
constant: false
type: Species
has only substance units: false
is encoded by: hsa:11041
initial amount: NaN

metaR r1923
modifier: MODEL1310110062#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_f2fdd497_ab14_4519_9afd_efb307d54677
is encoded by: hsa:293
initial concentration: NaN
is: Q6I9V5
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: SLC25A6
constant: false

metaR r1650
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110062#
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185

metaR HSD11B2r
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
is version of: http://identifiers.org/ec-code/1.1.1.146
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
name: 11-beta-hydroxysteroid dehydrogenase type 2
reactant: MODEL1310110062#
product: MODEL1310110062#

metaR CYSGLTH
name: Glutathione:cystine oxidoreductase
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110062#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#

metaR r0281
kinetic law: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/5.3.1.6
reactant: MODEL1310110062#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110062#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_1ed92d9d_38a8_4910_94ab_bf50a5db8ac7
has only substance units: false
constant: false
is encoded by: hsa:11182
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC2A6
is: Q9UGQ3

http://identifiers.org/biomodels.db/MODEL1310110062#_0dd8e2df_1bb6_4238_a3f8_f3be71c8896e
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: O43677
initial amount: NaN
is encoded by: hsa:4717
name: NDUFC1
has only substance units: false
constant: false

metaM pi n
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: HMDB00973
name: hydrogenphosphate
initial amount: NaN
constant: false
is: CHEBI:43474

metaM xol7a r
name: 20-hydroxycholesterol
boundary condition: false
is: CHEBI:1296
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01496
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c6682394_9b20_4649_aa56_46c8ec667532
boundary condition: true
initial amount: NaN
is encoded by: hsa:200010
initial concentration: NaN
is: E9PAK4
is: SBO:0000252
name: SLC5A9
constant: false
has only substance units: false
type: Species

metaR IDOAASE4ly
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
product: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_bd8a391a_1c5e_45bf_a75b_ffb0e8d24e3a
is encoded by: hsa:30
is: Q96CA6
has only substance units: false
type: Species
name: ACAA1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_2a274061_81df_4e27_810f_009f6dcadaa5
is: O95954
is: SBO:0000252
constant: false
is encoded by: hsa:10841
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: FTCD

metaM mi3p D c
initial concentration: 1.0
is: HMDB06814
initial amount: NaN
name: 1D-myo-inositol 3-phosphate(2-)
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
is: CHEBI:58401

http://identifiers.org/biomodels.db/MODEL1310110062#_47ef50ea_dfc1_46c7_9616_c6b6c3983f27
name: ALDH6A1
is: SBO:0000252
type: Species
has only substance units: false
is: Q02252
initial concentration: NaN
is encoded by: hsa:4329
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_49d9f263_7744_4d78_affc_229b65613d8c
has only substance units: false
constant: false
boundary condition: true
type: Species
name: AMY1C
is: SBO:0000252
is encoded by: hsa:278
initial concentration: NaN
is: P04745
initial amount: NaN

metaM CE5121 m
type: Species
is: CHEBI:57449
constant: false
is: SBO:0000247
initial amount: NaN
name: trans-3-decenoyl-CoA
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR CYOOm3
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is version of: http://identifiers.org/ec-code/1.9.3.1
is: SBO:0000185
kinetic law: MODEL1310110062#
name: cytochrome c oxidase, mitochondrial Complex IV
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110062#

metaM gchola x
has only substance units: false
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
is: CHEBI:58235
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00138
initial amount: NaN
name: glycocholate

metaR SARDHm
product: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.5.99.1
reactant: MODEL1310110062#
name: Sarcosine dehydrogenase (m)
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable

metaM pi m
is: C00009
initial concentration: 1.0
is: CHEBI:43474
constant: false
name: hydrogenphosphate
is: SBO:0000247
boundary condition: false
is: HMDB00973
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
type: Species

metaM Rtotal2 c
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB00095
initial concentration: 1.0
constant: false
is: C00055
type: Species
initial amount: NaN
is: CHEBI:60377
is: SBO:0000247
has only substance units: false
boundary condition: false
name: R total 2 position

http://identifiers.org/biomodels.db/MODEL1310110062#_6875779e_1822_4dfb_87da_0ef6d9ff68d7
is: Q9NPH0
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:51205
boundary condition: true
name: ACP6
has only substance units: false
initial amount: NaN

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_f470787a_b6bb_4256_b335_23d770a4c583
name: DGUOK
is encoded by: hsa:1716
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: E5KSL6
constant: false
boundary condition: true
type: Species

metaR 4NPHSFte
name: xenobiotic transport
is: SBO:0000185
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
reversible: true
fast: false
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_f0f8de50_de25_499a_917a_7135391c825b
is encoded by: hsa:30
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: Q96CA6
boundary condition: true
has only substance units: false
name: ACAA1

metaM glx x
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
type: Species
is: HMDB00119
is: CHEBI:36655
boundary condition: false
initial concentration: 1.0
name: glyoxylate
initial amount: NaN
has only substance units: false
constant: false

metaR HEXDICOAACBPx
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaR ADCim
name: Acetoacetate decarboxylation (irreversible), mitochondrial
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000176
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
reversible: false
fast: false

metaM chsterol r
has only substance units: false
name: cholesterol
initial amount: NaN
constant: false
is: HMDB00067
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
is: CHEBI:16113

metaM 3dhguln c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: CHEBI:57655
is: HMDB06334
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 3-dehydro-L-gulonate
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_1796ce53_dacb_47d4_9055_978b4423c4a5
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:N63787
name: _N63787_1_c
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM 10fthf7glu e
is: SBO:0000247
is: CHEBI:57454
is: HMDB00972
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C50H57N13O25 CHARGE: -8
constant: false
has only substance units: false
type: Species
name: 10-formyltetrahydrofolate-[Glu](7)

metaR G14T12g
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_aaba98ba_b632_4efe_bcc1_a43ef100f8ec
constant: false
name: DLAT
is: Q86YI5
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1737
boundary condition: true

metaM gua e
has only substance units: false
constant: false
name: guanine
is: CHEBI:16235
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
initial concentration: 1.0

metaM arachdcoa m
has only substance units: false
is: HMDB06523
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
constant: false
name: arachidonoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110062#_1eac31fd_7d74_454b_993b_1d1a646795ff
initial amount: NaN
is encoded by: hsa:8706
type: Species
name: B3GALNT1
boundary condition: true
initial concentration: NaN
constant: false
is: Q8TDY1
has only substance units: false
is: SBO:0000252

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM pi r
is: HMDB00973
is: C00009
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: hydrogenphosphate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_d185b026_a54b_4644_b541_83c3fe59a6a4
is: SBO:0000252
is: P50747
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: HLCS
constant: false
initial concentration: NaN
is encoded by: hsa:3141

http://identifiers.org/biomodels.db/MODEL1310110062#_6592f4a2_1ded_4e30_bfb0_410d230b3e1f
name: SLC38A3
is: Q99624
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:10991

metaR AG13T1g
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
fast: false
reactant: MODEL1310110062#
reversible: false
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#

metaM crvnc c
is: CHEBI:36005
initial concentration: 1.0
is: SBO:0000247
is: HMDB02183
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
name: cervonic acid, C22:6 n-3

metaM ksi deg40 l
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 40
is: CHEBI:12936
type: Species
initial concentration: 1.0
notes: FORMULA: C40H68N2O31 CHARGE: 0
is: SBO:0000247
is: HMDB00143

metaM hdcea r
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
boundary condition: false
name: palmitoleate
is: CHEBI:32372
is: SBO:0000247
has only substance units: false
is: HMDB03229

metaR FAOXC16OHC16r
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR RE3245C
fast: false
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110062#
is: SBO:0000176
type: Reaction
name: RE3245
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_cd588486_05f4_457c_804b_e0d014885823
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: IDUA
has only substance units: false
boundary condition: true
type: Species
is: P35475
is encoded by: hsa:3425

http://identifiers.org/biomodels.db/MODEL1310110062#_75c727a5_7e1e_41b9_bcfe_fc37a1f0349b
is: Q8TDQ7
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:132789
name: GNPDA2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_0647c773_3dbe_4974_b6ed_2861bcb185d0
is encoded by: hsa:6120
is: SBO:0000252
initial amount: NaN
is: Q53TV9
type: Species
initial concentration: NaN
name: RPE
has only substance units: false
constant: false
boundary condition: true

metaR AG13T14g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reactant: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_36eee616_70ba_40c4_83c9_7b256440c7db
name: TK2
initial concentration: NaN
boundary condition: true
constant: false
is: O00142
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7084

metaR ACNAMtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: N-acetylneuraminate nuclear import
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110062#

metaR r2006
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_589fed03_9027_4f12_9586_d8abe1fe247b
is encoded by: hsa:8833
has only substance units: false
initial concentration: NaN
name: GMPS
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: P49915

metaM ile L c
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
is: HMDB00172
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine

metaR CHAT
name: Choline O-acetyltransferase
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is: SBO:0000176
reversible: true
modifier: MODEL1310110062#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.6

metaR PPPG9tm
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
name: protoporphyrinogen IX mitochondrial transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567

http://identifiers.org/biomodels.db/MODEL1310110062#_502c0554_e1ee_4e3b_8ded_052162252a5d
type: Species
is: SBO:0000252
is: P20020
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:490
name: ATP2B1
constant: false
has only substance units: false

metaM rbt e
initial concentration: 1.0
has only substance units: false
is: CHEBI:15963
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00508
name: D-ribitol

http://identifiers.org/biomodels.db/MODEL1310110062#_37dda443_cc8e_4137_b42f_95428461405f
type: Species
initial concentration: NaN
name: SGMS1
initial amount: NaN
is encoded by: hsa:259230
is: D3DWC4
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

metaM nac c
initial amount: NaN
name: Nicotinate
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB01488
has only substance units: false
is: C00253
is: SBO:0000247
is: CHEBI:0

metaM sphgn c
name: sphinganine(1+)
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00269
is: CHEBI:57817
initial concentration: 1.0
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: SBO:0000247
type: Species

metaR KCC2t
reversible: true
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
fast: false
is described by: ECO:0000269
product: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
name: K+-Cl- cotransporter (NH4+)

http://identifiers.org/biomodels.db/MODEL1310110062#_aa8d60ce_884b_4e51_bd25_1692c65c5607
type: Species
initial amount: NaN
name: ACHE
initial concentration: NaN
is encoded by: hsa:43
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaR r2004
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_8112078c_c09d_4c07_9237_b187828d9b1d
name: NDUFAB1
initial amount: NaN
is: O14561
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4706
has only substance units: false

metaR G12MT1 L
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110062#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
fast: false
type: Reaction
kinetic law: MODEL1310110062#
reversible: false
is described by: ECO:0000000

metaM HC02213 e
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:28031

metaM ile L m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:17191
name: L-isoleucine

metaR CYTK3n
name: cytidylate kinase (dCMP,CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
reversible: true
product: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176

metaR PI45PLC
fast: false
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11

metaR URIt
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110062#
name: uridine facilated transport in cytosol
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110062#

metaR SUCD1m
is described by: ECO:0000134
modifier: MODEL1310110062#
name: succinate dehydrogenase
type: Reaction
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
reversible: true
is version of: http://identifiers.org/ec-code/1.3.5.1
is: SBO:0000176
kinetic law: MODEL1310110062#
product: MODEL1310110062#

metaM e4hglu m
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
constant: false
is: SBO:0000247
is: HMDB02273
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:6331
name: erythro-4-hydroxy-L-glutamate(1-)
boundary condition: false

metaM fadh2 m
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
is: C01352
name: Flavin adenine dinucleotide reduced
boundary condition: false
type: Species
constant: false
is: HMDB01197
has only substance units: false
initial concentration: 1.0
is: CHEBI:58307
initial amount: NaN

metaR PI4P3K
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
reversible: false
modifier: MODEL1310110062#
product: MODEL1310110062#

metaR r0287
fast: false
reversible: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110062#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR r0512
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
fast: false
product: MODEL1310110062#
type: Reaction

metaM chsterol m
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: cholesterol
is: CHEBI:16113
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false

metaM rbt c
initial concentration: 1.0
type: Species
is: CHEBI:15963
name: D-ribitol
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
initial amount: NaN

metaM HC01361 e
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
is: SBO:0000247
is: CHEBI:17001
initial amount: NaN
name: Dihydroneopterin
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_902d228a_7ab9_4fd5_bdb2_649e53b04bf9
is: Q9UFY1
constant: false
name: PLCG1
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5335
type: Species

metaM tettet6coa c
is: http://identifiers.org/pubchem.compound/47205481
boundary condition: false
type: Species
is: HMDB06516
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: C16171
has only substance units: false
initial concentration: 1.0
name: tetracosatetraenoyl coenzyme A

metaR 4MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
is described by: ECO:0000000
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185

metaM gua c
boundary condition: false
initial amount: NaN
is: CHEBI:16235
is: SBO:0000247
type: Species
is: HMDB00132
name: Guanine
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: C00242

metaR r2002
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110062#_8f4feee0_6f7c_4ea1_92a6_166f4d53d7ee
is: SBO:0000252
type: Species
name: _AA629629_1_m
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:AA629629

metaR ACACT1r
name: acetyl-CoA C-acetyltransferase
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
product: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_bf034503_5bf2_44c9_9d04_4e7e699103ce
name: CA1
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: P00915
is encoded by: hsa:759

metaM HC02213 c
constant: false
is: CHEBI:28031
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
has only substance units: false
name: prostaglandin-e3
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM chsterol l
initial amount: NaN
is: HMDB00067
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
has only substance units: false
is: CHEBI:16113

metaR FAOXC2452256x
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110062#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_03f27e4b_5eff_42c8_a004_ffa2b9def702
is: SBO:0000252
is encoded by: hsa:R33828
boundary condition: true
constant: false
initial concentration: NaN
name: _R33828_1_c
has only substance units: false
initial amount: NaN
type: Species

metaM mhista c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
name: N(tele)-methylhistaminium
is: CHEBI:58600
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB00898

http://identifiers.org/biomodels.db/MODEL1310110062#_d32bbbb4_9018_4f92_b881_6dc9168ba021
is encoded by: hsa:54344
initial concentration: NaN
is: SBO:0000297
has only substance units: false
type: Species
constant: false
name: DPM3:DPM1:DPM2
is encoded by: hsa:8818
has part: Q9P2X0
initial amount: NaN
boundary condition: true

metaR FACOAL150
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110062#
name: fatty-acid--CoA ligase
is: SBO:0000176

metaR LEUKTRB4t
reactant: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
fast: false
is: SBO:0000185
name: leukotriene B4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

metaR Ser Thrtg
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
name: Ser/Thr transport (from golgi to lysosome)
reversible: true
is described by: ECO:0000269
product: MODEL1310110062#
fast: false
is: SBO:0000185
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_4094b595_dd37_4425_b93f_44f8dc609ccf
is encoded by: hsa:4952
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: OCRL
is: Q01968

http://identifiers.org/biomodels.db/MODEL1310110062#_93d571c5_cf95_4f74_89d8_d5f258da9f34
boundary condition: true
constant: false
is encoded by: hsa:56894
is: Q9NRZ7
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: AGPAT3
initial concentration: NaN
type: Species

metaM tdcoa c
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C02593
type: Species
has only substance units: false
is: HMDB01521
boundary condition: false
is: CHEBI:57385

metaM ksi pre33 g
is: CHEBI:58053
constant: false
type: Species
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 33
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00175
is: C00130
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_00d9b819_e2a2_4922_84c3_f508711bb848
is: Q9Y3Y1
name: SLC26A6
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:65010
constant: false
has only substance units: false
is: SBO:0000252

metaM subeac c
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
name: suberic acid
has only substance units: false
is: HMDB00893
notes: FORMULA: C8H12O4 CHARGE: -2
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_d25484de_6e97_4f94_b087_2f401c0e45b1
boundary condition: true
constant: false
is: SBO:0000252
is: Q9Y672
name: ALG6
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:29929
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_1c332f41_7a08_450d_8857_b47526682558
is: Q9H2F3
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: HSD3B7
initial amount: NaN
is encoded by: hsa:80270

metaM pre prot r
has only substance units: false
is: CHEBI:16038
notes: FORMULA: XY CHARGE: 0
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: glycophosphatidylinositol (GPI)-anchored protein precursor
type: Species
is: SBO:0000247
constant: false

metaR RETNt
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
name: retinoic acid transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_cad8cb2e_475a_4127_b2db_04d52d27a584
is: SBO:0000252
is encoded by: hsa:51102
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: MECR
has only substance units: false
is: Q9BV79
constant: false

metaR NDPK10
kinetic law: MODEL1310110062#
is described by: ECO:0000134
modifier: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
reactant: MODEL1310110062#
name: nucleoside-diphosphate kinase (ATP:dIDP)
reversible: true
product: MODEL1310110062#
type: Reaction

metaR FAEL183
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110062#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
modifier: MODEL1310110062#
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
type: Reaction
kinetic law: MODEL1310110062#
reversible: false

metaR r0517
kinetic law: MODEL1310110062#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110062#
reversible: true
type: Reaction

metaR PRO1xm
is version of: http://identifiers.org/ec-code/1.5.99.8
fast: false
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000254
name: proline oxidase (NAD), mitochondrial
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
reversible: false

metaR r2000
reversible: false
modifier: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110062#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_00214391_5e13_4180_8fc1_03429c2bbce4
is: SBO:0000252
boundary condition: true
name: ALG8
constant: false
type: Species
is encoded by: hsa:79053
initial amount: NaN
has only substance units: false
is: Q9BVK2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_e533a64e_0172_4744_8321_4ef6f28f89a5
constant: false
initial concentration: NaN
name: DBT:DLD:BCKDHA:BCKDHB
initial amount: NaN
has only substance units: false
is: SBO:0000297
boundary condition: true
has part: Q9BQL0
is encoded by: hsa:594
type: Species

metaR 3DSPHR
is version of: http://identifiers.org/ec-code/1.1.1.102
is: SBO:0000176
fast: false
kinetic law: MODEL1310110062#
name: 3-Dehydrosphinganine reductase
reactant: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
is described by: ECO:0000269
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_8a62e360_f888_4e22_9d79_8c98764ea8da
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: SLC23A2
is encoded by: hsa:9962
boundary condition: true
has only substance units: false
initial amount: NaN

metaM pap g
has only substance units: false
is: CHEBI:58343
is: SBO:0000247
constant: false
is: HMDB00061
initial concentration: 1.0
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial amount: NaN
type: Species
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_a67bde4c_08c2_4adf_b255_51988b639192
name: PLCB1
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: Q9NQ66
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23236

http://identifiers.org/biomodels.db/MODEL1310110062#_06692ad5_3332_4a82_8b48_d8671b3d80cc
name: KYNU
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8942
is: Q16719

metaR PI345P5P
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56

metaM ksii core4 e
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
is: HMDB00211
initial amount: NaN
is: CHEBI:17268
initial concentration: 1.0
boundary condition: false

metaM gchola e
name: glycocholate
is: HMDB00138
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

metaR O2t
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
name: o2 transport (diffusion)
type: Reaction
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185

metaR FAEL184
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is: SBO:0000176
modifier: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: false

metaM pi x
is: HMDB00973
name: hydrogenphosphate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:43474
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
type: Species

metaM fadh2 r
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01197
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_8fdad7a5_be14_4da3_82f7_3a742f86a4e7
initial amount: NaN
name: _NOS2A_1_e
boundary condition: true
is encoded by: hsa:NOS2A
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaM lpam m
constant: false
is: SBO:0000247
is: CHEBI:17460
has only substance units: false
name: lipoamide
is: HMDB00962
type: Species
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_99a59917_0eb5_43c4_81a1_990e05704aad
is: SBO:0000252
is: Q8NEM3
has only substance units: false
boundary condition: true
constant: false
name: SLC16A7
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:9194

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM s2l2n2m2mn l
constant: false
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
initial concentration: 1.0
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: CHEBI:30825
is: HMDB00573
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_1e7e2b21_7e32_424b_873f_934dab10dd28
initial amount: NaN
name: _AI971036_1_c
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI971036
constant: false

metaR DCSPTN1CPT2
name: carnitine transferase
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110062#_f398d611_e257_4e22_911e_9331593d8e16
has only substance units: false
is: A6H8L5
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: LIPC
initial amount: NaN
is encoded by: hsa:3990
boundary condition: true

metaM dadp c
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: C00206
has only substance units: false
constant: false
type: Species
is: HMDB01508
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:57667
name: dADP

http://identifiers.org/biomodels.db/MODEL1310110062#_e9ef25bf_2727_4e5b_872d_312209962e40
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:10195
initial concentration: NaN
name: ALG3
is: SBO:0000252

metaR HDCACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM lac L x
is: CHEBI:16651
is: SBO:0000247
constant: false
is: HMDB00190
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
initial concentration: 1.0
name: (S)-lactate
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_7306eba9_daa0_4f4d_9c2f_940734121a16
initial concentration: NaN
initial amount: NaN
name: SGPP2
is encoded by: hsa:130367
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q8IWX5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_ab7b7d1a_2650_43eb_9a06_7a26422a9260
initial concentration: NaN
is encoded by: hsa:123041
initial amount: NaN
name: SLC24A4
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true

metaR r2437
product: MODEL1310110062#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
type: Reaction
reversible: false
kinetic law: MODEL1310110062#

metaR PSt3
name: phosphatidylserine transport
kinetic law: MODEL1310110062#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110062#
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_5bec5929_94af_4b2f_aaf3_94cdbebf1a4a
has only substance units: false
type: Species
initial amount: NaN
name: CMAS
is: Q8NFW8
constant: false
is encoded by: hsa:55907
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR DCSPTN1CPT1
is described by: ECO:0000269
reactant: MODEL1310110062#
name: carnitine O-palmitoyltransferase
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110062#
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_metaR_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange
type: Reaction

metaM 5pmev x
is: SBO:0000247
is: CHEBI:58146
constant: false
is: HMDB01343
name: (R)-5-phosphonatomevalonate(3-)
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_23f0ac75_d1d6_4833_8c00_bbc718537b81
initial concentration: NaN
is: SBO:0000252
type: Species
name: HAO2
constant: false
boundary condition: true
is: Q9NYQ3
has only substance units: false
is encoded by: hsa:51179
initial amount: NaN

metaM m2mpdol L c
initial concentration: 1.0
is: CHEBI:28049
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
has only substance units: false
type: Species
constant: false

metaM ksii core4 g
constant: false
type: Species
has only substance units: false
is: CHEBI:57255
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01014

metaM ksii core4 pre5 g
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 5
initial concentration: 1.0
constant: false
is: HMDB00175
is: C00130
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C69H112N6O48X CHARGE: -1
has only substance units: false

metaM clpndcoa c
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial amount: NaN
name: clupanodonyl CoA
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB06267
is: C16166
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/47205476

metaR DUTPDPn
fast: false
product: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.6.1.23
type: Reaction
is: SBO:0000176
modifier: MODEL1310110062#
is described by: ECO:0000269
name: dUTP diphosphatase, nuclear

metaM gchola c
has only substance units: false
initial amount: NaN
is: CHEBI:58235
boundary condition: false
is: HMDB00138
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false
name: glycocholate

metaR ACACT1x
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: false
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
modifier: MODEL1310110062#
fast: false
is: SBO:0000176
type: Reaction

metaR r0408
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
reactant: MODEL1310110062#
type: Reaction
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11

http://identifiers.org/biomodels.db/MODEL1310110062#_54dea3aa_8612_49d2_9d7d_8bb0944679ef
type: Species
name: DHFR
constant: false
is: P00374
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1719
initial amount: NaN
boundary condition: true

metaR FACOAL260
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
kinetic law: MODEL1310110062#
reversible: true
is: SBO:0000176
name: fatty-acid--CoA ligase (n-C26:0)

metaM hexe3coa m
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: HMDB06522
has only substance units: false
name: 3-hexenoylcoa
initial concentration: 1.0

metaM malthp e
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
name: maltoheptaose
is: C01936

metaM pap c
is: CHEBI:58343
constant: false
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial concentration: 1.0
is: HMDB00061
type: Species
has only substance units: false
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
is: SBO:0000247

metaM ksii core2 deg3 l
has only substance units: false
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 3
initial concentration: 1.0
is: CHEBI:12936
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: HMDB00143

metaM 13dampp c
name: trimethylenediaminium
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: SBO:0000247
is: HMDB00002
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57484
initial concentration: 1.0
type: Species
has only substance units: false

metaR r0666
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
modifier: MODEL1310110062#
type: Reaction

metaM bhb m
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
is: SBO:0000247
is: HMDB00011
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
has only substance units: false
constant: false
type: Species
is: CHEBI:10983

metaR NACHEXA21ly
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
modifier: MODEL1310110062#

metaM arachdcoa x
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06523
is: CHEBI:57368
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)

metaM CE1940 e
is: HMDB02786
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:16301
type: Species
boundary condition: false
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
name: spermidine monoaldehyde 2
initial concentration: 1.0

metaM chsterol e
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00067
is: CHEBI:16113
is: SBO:0000247
name: cholesterol
initial concentration: 1.0
boundary condition: false
constant: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM ptth m
name: pantetheine
initial concentration: 1.0
constant: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: HMDB03426
is: CHEBI:16753
initial amount: NaN

metaM n2m2nmasn l
type: Species
is: SBO:0000247
initial amount: NaN
is: C04946
boundary condition: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
constant: false
has only substance units: false

metaR FAOXC102C103m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR r0879
fast: false
is: SBO:0000185
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
reversible: false
type: Reaction
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#

metaR r0407
reactant: MODEL1310110062#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110062#
fast: false
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR ARACHCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
name: carnitine transferase
is: SBO:0000176

metaR PSDm hs
modifier: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.65
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000269
name: Phosphatidylserine decarboxylase
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
fast: false
reversible: false

metaM g3m8masn r
constant: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: C05873
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR FAOXC3DC
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e4dbcc71_e6a8_435a_9b88_268d2f6f74ed
name: RDH11
constant: false
boundary condition: true
is encoded by: hsa:51109
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: B4DDW0

metaR PCHOLPg hs
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is: SBO:0000176
name: choline phosphatase
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_100504f3_70f9_4b19_bbea_d7bd8b5c0660
initial concentration: NaN
is: O75387
is encoded by: hsa:8501
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: SLC43A1

http://identifiers.org/biomodels.db/MODEL1310110062#_54685682_d859_42c4_9bb9_bd22f4711fcf
has only substance units: false
initial amount: NaN
type: Species
name: SLC3A2
is encoded by: hsa:6520
boundary condition: true
constant: false
initial concentration: NaN
is: P08195
is: SBO:0000252

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

metaR S6T17g
is described by: ECO:0000000
modifier: MODEL1310110062#
product: MODEL1310110062#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction

metaM chsterol c
constant: false
type: Species
is: CHEBI:16113
initial amount: NaN
is: HMDB00067
name: cholesterol
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_52085161_f710_4365_83bb_d3c9eb71bb53
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q02218
has only substance units: false
is encoded by: hsa:4967
is: SBO:0000252
boundary condition: true
name: OGDH

metaR PRO Dtde
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110062#
fast: false
name: D-proline transport, extracellular
reversible: true

metaR CSPG Etly
name: chondroitin sulfate E transport, extracellular to lysosome
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000000

metaM occoa c
constant: false
boundary condition: false
has only substance units: false
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
is: CHEBI:57386
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
is: SBO:0000247
initial amount: NaN

metaR IZPN
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110062#
is: SBO:0000176
fast: false
reactant: MODEL1310110062#
name: Imidazolonepropionase
product: MODEL1310110062#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_6df3eb44_1518_40c6_84c3_89fa94a74285
name: SLC7A5
initial concentration: NaN
type: Species
is: Q8IV97
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8140
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_5a2dca47_4571_4a9d_8d63_7feb9aaa5e39
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:1738
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P09622
name: DLD

metaR PI34P5K
kinetic law: MODEL1310110062#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.68
reversible: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
modifier: MODEL1310110062#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false

metaR NACHEX27ly
is described by: ECO:0000269
modifier: MODEL1310110062#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_87d43417_bf8e_41bc_b5a6_b4112d3fade9
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: OGDHL
is: Q9ULD0
type: Species
is encoded by: hsa:55753
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9bb516ed_c4cb_45a0_a056_07ca0a8edc1a
has only substance units: false
is encoded by: hsa:8879
name: SGPL1
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: O95470
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_4b53822a_c317_4c2f_aef6_b0f53d14d2a8
is: SBO:0000252
is encoded by: hsa:79611
constant: false
initial concentration: NaN
boundary condition: true
is: Q9H6R3
name: ACSS3
initial amount: NaN
has only substance units: false
type: Species

metaM fadh2 c
boundary condition: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58307
initial amount: NaN
name: FADH2(2-)
is: HMDB01197
constant: false
type: Species
has only substance units: false

metaR BILDGLCURt
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000185
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
type: Reaction
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ

metaR FUT910g
name: Alpha-(1,3)-fucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.152
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction

metaR DCSPTN1CRNt
is: SBO:0000185
modifier: MODEL1310110062#
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110062#

metaM itacon m
is: HMDB02092
type: Species
is: SBO:0000247
name: itaconate(2-)
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
has only substance units: false
initial concentration: 1.0
is: CHEBI:17240
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_cada3a8f_1972_4fac_b4a8_2a03053198a0
is: SBO:0000252
has only substance units: false
is: Q13733
type: Species
initial amount: NaN
name: ATP1A4
is encoded by: hsa:480
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_aa89bcbe_a161_43d1_8068_6c638befa152
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: RRM2
constant: false
is: P31350
is encoded by: hsa:6241
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_99647ec6_3778_458f_a7b6_979f0bc68795
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110062#_9d167b23_98f3_4eaa_9f34_36a45da38456
constant: false
initial amount: NaN
is: SBO:0000252
name: ALDH3B2
is: P48448
initial concentration: NaN
is encoded by: hsa:222
boundary condition: true
type: Species
has only substance units: false

metaR RE2814R
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
reversible: true

metaM tetpent6coa c
boundary condition: false
type: Species
is: C16172
initial amount: NaN
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
constant: false
name: tetracosapentaenoyl coenzyme A, n-6
is: SBO:0000247
initial concentration: 1.0

metaR r1647
is: SBO:0000185
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110062#

metaM adrn c
type: Species
name: adrenic acid
has only substance units: false
initial concentration: 1.0
is: CHEBI:53487
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaM fol c
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
type: Species
initial concentration: 1.0
constant: false
is: HMDB00121
is: SBO:0000247

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM ttdca e
name: tetradecanoate (n-C14:0)
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: C06424
initial concentration: 1.0
initial amount: NaN
is: HMDB00806
is: CHEBI:30807
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_995000a6_9e06_46e1_935c_bb5a06a8be4f
name: LEFTY1
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10637
is: O75610
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_7212f35a_e7fe_4d7a_9b13_a70d4c5ebbf5
name: PIK3CD:PIK3R1
type: Species
has part: E7EX19
is encoded by: hsa:5295
is: SBO:0000297
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM hexdicoa r
constant: false
name: hexadecanedioylcoa
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00672
is: SBO:0000247
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
boundary condition: false
is: C08260

metaR GASNASE3ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.26
name: glycosylasparaginase, lysosomal
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
product: MODEL1310110062#
is described by: ECO:0000000

metaR r0403
product: MODEL1310110062#
fast: false
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_e06dac09_c7bc_4e33_940b_6331a25fdd37
initial concentration: NaN
name: DGKH
is: Q86XP1
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:160851

metaR r1648
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_b980aea9_4706_417a_8777_0717df3c720b
is: SBO:0000252
has only substance units: false
is: Q5JT09
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:83549
type: Species
name: UCK1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_4a4da3d0_6147_4317_8426_d76f095df190
initial amount: NaN
is encoded by: hsa:2544
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: _2544_1_c
type: Species
initial concentration: NaN

metaM nac e
name: Nicotinate
constant: false
has only substance units: false
notes: FORMULA: C6H4NO2 CHARGE: -1
is: C00253
initial amount: NaN
boundary condition: false
is: HMDB01488
is: CHEBI:0
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR r0399
reactant: MODEL1310110062#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reversible: true
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
product: MODEL1310110062#
fast: false
modifier: MODEL1310110062#

metaR r0660
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110062#

metaM hdcea c
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:32372
name: Hexadecenoate (n-C16:1)
initial concentration: 1.0
constant: false
is: HMDB03229

metaR r1649
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
modifier: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_3f4ddbd9_37e7_4769_ae5b_fe738101aa75
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: P14550
name: AKR1A1
is encoded by: hsa:10327
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM 2docopencoa m
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB06294
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
name: 2,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0

metaR RE1525M
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
reactant: MODEL1310110062#
type: Reaction
reversible: true
product: MODEL1310110062#
is: SBO:0000176
fast: false
name: RE1525
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM fum m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false
type: Species
name: Fumarate
is: C00122
is: CHEBI:29806
is: HMDB00134
boundary condition: false
initial amount: NaN

metaM l2n2m2mn l
notes: FORMULA: C54H91N3O41 CHARGE: 0
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: HMDB00143

metaM 2mbcoa m
has only substance units: false
initial concentration: 1.0
is: HMDB01041
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
constant: false
is: CHEBI:57336
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 2-methylbutanoyl-CoA(4-)

metaM tdchola c
is: HMDB00951
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
has only substance units: false
initial concentration: 1.0
name: taurochenodeoxycholate
constant: false
is: CHEBI:9407
boundary condition: false

metaM HC01412 m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:61405
name: trans-tetradec-2-enoyl-CoA(4-)
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273

metaM ttdca c
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00806
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
name: myristate
is: CHEBI:30807
type: Species
is: SBO:0000247
constant: false

metaR FAOXTC182TC162m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_0eaf999c_37f7_4b54_a452_ee95cec88141
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:56922
boundary condition: true
initial concentration: NaN
is: SBO:0000297
name: MCCC1:MCCC2
has part: Q96RQ3
has only substance units: false
is encoded by: hsa:64087
has part: Q9HCC0

metaR RE3627M
reactant: MODEL1310110062#
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110062#
type: Reaction
name: RE3627

metaM dcsptn1coa x
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
type: Species
initial concentration: 1.0
is: C16173
constant: false
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN
is: SBO:0000247

metaM 4aphdob c
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
initial amount: NaN
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
boundary condition: false
is: HMDB00978
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:58147
type: Species
is: SBO:0000247

metaM mi1p D c
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
constant: false
is: HMDB02985
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58433

metaR MI34PP
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
type: Reaction
modifier: MODEL1310110062#
product: MODEL1310110062#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.66
name: inositol-3,4-bisphosphate 4-phosphatase
is: SBO:0000176
reactant: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#

metaM cs e deg7 l
initial concentration: 1.0
is: CHEBI:15936
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H35O27S2 CHARGE: -3
initial amount: NaN
constant: false
boundary condition: false

metaR r0647
name: Spontaneous reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:

metaM hpdcacrn c
is: SBO:0000247
type: Species
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: heptadecanoyl carnitine
is: HMDB06210

metaR RTOTAL3t
kinetic law: MODEL1310110062#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
name: RTOTAL3 transport

metaR LALDO2x
type: Reaction
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
reversible: false
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000269
fast: false

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR CYOR u10m
name: ubiquinol-6 cytochrome c reductase, Complex III
fast: false
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134
product: MODEL1310110062#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is: SBO:0000185
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110062#

metaM CE5101 m
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57795
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR r0870
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.3.4
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/2.7.7.72
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:

metaM n2m2nmasn e
has only substance units: false
type: Species
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: C04946
initial amount: NaN

metaR r1051
name: Vesicular transport
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM core2 g
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: Core 2
is: CHEBI:15876
has only substance units: false
type: Species
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: SBO:0000247

metaR FUMTSULtm
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
name: Fumarate:thiosulfate antiport, mitochondrial
modifier: MODEL1310110062#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110062#_6f2e4e37_df7a_4635_bfe2_0e34cc6322e0
type: Species
is encoded by: hsa:122622
initial concentration: NaN
initial amount: NaN
is: Q8N142
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: ADSSL1

metaR r1669
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110062#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#
fast: false

metaR EX tetdece1crn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_73d52d6b_b8a7_4c8d_bcc7_c98edd57c07d
is encoded by: hsa:2180
has only substance units: false
is: SBO:0000252
is: P33121
initial amount: NaN
initial concentration: NaN
constant: false
name: ACSL1
boundary condition: true
type: Species

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR PIK5
is: SBO:0000176
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9660759 NOTES:NCD
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.68
product: MODEL1310110062#
modifier: MODEL1310110062#
name: phosphatidylinositol 5-kinase
reactant: MODEL1310110062#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_ee90c3fc_8f7e_46a9_bd7e_5700336c376f
constant: false
is encoded by: hsa:4758
has only substance units: false
name: NEU1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q99519
initial amount: NaN

metaR LAPCOAl
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
name: lysosomal acid phosphorylase (CoA)
type: Reaction
reversible: false
reactant: MODEL1310110062#

metaM hdd2coa m
is: HMDB03945
initial amount: NaN
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
is: SBO:0000247
type: Species
is: C05272
initial concentration: 1.0
has only substance units: false
constant: false
name: trans-Hexadec-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110062#_ff26fdce_903f_46a2_86e1_df60d1c2a83d
is encoded by: hsa:8875
is: SBO:0000297
name: VNN3:VNN2:VNN1
has part: O95497
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8876
initial amount: NaN
is encoded by: hsa:55350
has only substance units: false
has part: A8K7W0
initial concentration: NaN

metaR FUT18g
product: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
type: Reaction

metaR r0871
is described by: ECO:0000000
name: Diffusion
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
type: Reaction

metaR r0423
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false

metaM strdnc c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205608
is: C16300
name: stearidonic acid C18:4, n-3
initial concentration: 1.0
is: HMDB06547
type: Species
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false

metaR GCCcm
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
kinetic law: MODEL1310110062#

metaR r1050
is: SBO:0000185
is described by: ECO:0000000
name: Vesicular transport
reversible: true
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110062#
fast: false

metaR C14OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR r1668
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM xtsn c
is: HMDB00299
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: CHEBI:18107
has only substance units: false
name: xanthosine
is: SBO:0000247
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_9bd49247_92ca_43c9_8cc6_6554257eb4fb
constant: false
initial concentration: NaN
name: _T83654_1_e
boundary condition: true
is encoded by: hsa:T83654
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM m4mpdol L c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:37633
constant: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM sbcoa x
constant: false
initial concentration: 1.0
name: suberylcoa
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

metaM pentcoa m
is: HMDB13037
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
name: pentanoylcoa
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: C00888
is: SBO:0000247
type: Species

metaM HC01603 c
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57454
initial concentration: 1.0
has only substance units: false
name: 10-Formyltetrahydrofolate
is: SBO:0000247
is: C00234
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaM tdchola e
is: HMDB00951
constant: false
is: CHEBI:9407
name: taurochenodeoxycholate
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0

metaR r0381
is: SBO:0000176
reactant: MODEL1310110062#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
reversible: true
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_3b73dde0_114a_40a2_9353_b05c7b424c6f
initial concentration: NaN
type: Species
constant: false
name: ALDH3B1
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:221
has only substance units: false
is: P43353

metaR AG13T13g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction

metaR r1667
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_4d00f317_6a68_4eeb_a8a9_055b77b8cfea
is: SBO:0000252
is encoded by: hsa:3417
initial amount: NaN
has only substance units: false
name: IDH1
boundary condition: true
is: O75874
type: Species
constant: false
initial concentration: NaN

metaR SUCOAS1m
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
name: Succinate--CoA ligase (GDP-forming)
fast: false
modifier: MODEL1310110062#

metaM g2m8mpdol L r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: C05870
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20

metaR TDCHOLAtx
reversible: true
name: bile acid intracellular transport
kinetic law: MODEL1310110062#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000

metaR PIK3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: phosphatidylinositol 3-kinase
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154

http://identifiers.org/biomodels.db/MODEL1310110062#_076782b9_af27_46a1_a47b_60a261995307
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q15181
type: Species
constant: false
name: PPA1
boundary condition: true
is encoded by: hsa:5464
initial concentration: NaN

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_c28174c7_80a8_4050_b975_9b0b3e2c160c
has only substance units: false
type: Species
initial concentration: NaN
is: B2RAT6
constant: false
name: GALT
is: SBO:0000252
is encoded by: hsa:2592
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_35adce5c_9957_46d3_ba62_313d49ce61b9
is encoded by: hsa:1962
is: Q9NY65
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: EHHADH

http://identifiers.org/biomodels.db/MODEL1310110062#_763ac2e6_b3db_4adf_922d_b54af36cb7f3
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: _728637_1_c
is: SBO:0000252
is encoded by: hsa:728637
initial amount: NaN
has only substance units: false

metaM HC00591 c
initial amount: NaN
name: 2-oxoglutaramate
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:16769
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
constant: false

metaM CE1936 e
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
name: spermine dialdehyde
is: CHEBI:36781
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936

metaR r1666
name: Y+LAT2 Utilized transport
modifier: MODEL1310110062#
is: SBO:0000185
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_d191788f_b13e_4e3d_86ac_f28a5a63cb81
boundary condition: true
type: Species
initial amount: NaN
is: Q92523
is encoded by: hsa:1375
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: CPT1B

metaR HACD9m
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
reversible: true
type: Reaction

metaR H2ETer
name: H2 phosphoethanolaminyl transferase, endoplasmic reticulum
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000304
modifier: MODEL1310110062#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
kinetic law: MODEL1310110062#
fast: false

metaR SPODMm
modifier: MODEL1310110062#
fast: false
name: superoxide dismutase
is: SBO:0000176
type: Reaction
product: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110062#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_8f65a819_01cf_4f2b_b463_34da8faef59d
initial concentration: NaN
is encoded by: hsa:10380
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: O95861
has only substance units: false
name: BPNT1
type: Species
constant: false

metaM Rtotalcoa c
has only substance units: false
is: CHEBI:16189
name: R total Coenzyme A
is: HMDB01448
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR ADPACTD
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaM gly x
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: glycine
is: CHEBI:15428
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
has only substance units: false

metaR GALASE4ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reactant: MODEL1310110062#
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
product: MODEL1310110062#
reversible: false

metaR PI4PP
is: SBO:0000176
product: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
name: phosphatidylinositol-4-phosphate 4-phosphatase
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
fast: false

metaR ARACHCPT1
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
name: carnitine transferase
fast: false
is: SBO:0000176
reactant: MODEL1310110062#
reversible: false

metaR r1665
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaR FACOAL2042
reversible: true
reactant: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110062#
product: MODEL1310110062#
name: fatty-acid--CoA ligase
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ

metaM so4 e
initial amount: NaN
name: sulfate
type: Species
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16189
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448

metaR r0644
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110062#
reversible: true

metaR C40CPT1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_56dd0807_6211_403f_8db5_bf874a8ba948
name: DAD1
has only substance units: false
is: Q53G02
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1603
constant: false
boundary condition: true

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR DRPA
is: SBO:0000176
reversible: false
name: deoxyribose-phosphate aldolase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000

metaR RE3050R
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reactant: MODEL1310110062#
product: MODEL1310110062#
name: RE3050
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110062#

metaM oaa x
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00223
name: Oxaloacetate
boundary condition: false
type: Species
is: CHEBI:16452
is: C00036

metaR GCHOLAt2
product: MODEL1310110062#
modifier: MODEL1310110062#
name: glycocholate transport via sodium cotransport
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110062#

metaR DNDPt36m
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: dGDP transport via dCDP antiport

http://identifiers.org/biomodels.db/MODEL1310110062#_9e3e76b5_de4d_4647_9214_743286746550
is encoded by: hsa:8879
is: SBO:0000252
name: SGPL1
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: O95470
initial concentration: NaN
boundary condition: true

metaR TRPt
name: L-tryptophan transport
is described by: ECO:0000269
kinetic law: MODEL1310110062#
reversible: true
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
fast: false

metaM lac L e
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00190
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16651
name: (S)-lactate

http://identifiers.org/biomodels.db/MODEL1310110062#_e949c62c_f9c6_49c5_9bc6_fa8d49ce65b7
is: SBO:0000252
name: SLC25A4
is: P12235
type: Species
has only substance units: false
is encoded by: hsa:291
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR r1664
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
type: Reaction
reversible: true

metaR ALATHRNaEx
reversible: false
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#

metaR OCTDECE1CRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_8c4754af_2144_4387_8cc4_3b00618ded2f
is: Q96G03
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: PGM2
has only substance units: false
type: Species
is encoded by: hsa:55276
boundary condition: true

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaM dhlam m
is: CHEBI:17694
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00985
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
name: dihydrolipoamide
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_7fd14e25_0ca5_49d7_adf0_a2ace0ec9f14
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:AI769281
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _AI769281_1_e

metaM HC01162 c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: CHEBI:58376
type: Species
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691

metaR DAG HSter
fast: false
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: diacylglycerol ER export
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_95df9689_f06e_4ab6_ab03_d3f1781da124
constant: false
boundary condition: true
type: Species
name: PRDX3
is encoded by: hsa:10935
has only substance units: false
is: P30048
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_1e308c6e_2d98_488e_8aa3_9c1c1648d328
name: _AI934540_1_c
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI934540
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM dcsptn1crn c
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB06321
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+

http://identifiers.org/biomodels.db/MODEL1310110062#_eafaa789_b701_48e5_a1f0_4d1b4ff28fdb
is: Q16873
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:4056
has only substance units: false
initial amount: NaN
name: LTC4S

metaM xol7aone r
boundary condition: false
is: HMDB01993
is: CHEBI:17899
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one

metaM so4 c
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
is: HMDB01448
initial concentration: 1.0
name: sulfate
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:16189
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_549cfed5_7915_47c9_a09e_320af6cd3636
initial amount: NaN
name: SLC1A4
has only substance units: false
is encoded by: hsa:6509
type: Species
is: SBO:0000252
constant: false
is: P43007
boundary condition: true
initial concentration: NaN

metaR P450SCC1m
is described by: ECO:0000134
type: Reaction
product: MODEL1310110062#
fast: false
name: cholesterol monooxygenase
is: SBO:0000176
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
reversible: true

metaR r1662
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110062#

metaM lac L c
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
constant: false
name: (S)-lactate
has only substance units: false
is: HMDB00190
boundary condition: false
is: CHEBI:16651

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR FBA
is described by: ECO:0000134
reversible: true
name: fructose-bisphosphate aldolase
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.1.2.13
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#

metaM dha e
name: glycerone
initial amount: NaN
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: CHEBI:16016
boundary condition: false
is: HMDB01882
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_85ee630e_7ea1_44f2_8a10_116ff35cd717
type: Species
name: PPA2
is: F8WDN9
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:27068

metaR r1774
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaR PRASCS
fast: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.6

http://identifiers.org/biomodels.db/MODEL1310110062#_13a11b4b_3bae_4b99_b8b4_5614bcef5514
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2348
has only substance units: false
type: Species
is: SBO:0000252
name: FOLR1
initial amount: NaN

metaR HPDCAt
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110062#
type: Reaction
fast: false
reversible: true
name: fatty acid transport via diffusion
is described by: ECO:0000000

metaR r1661
modifier: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR MDHm
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.37
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
kinetic law: MODEL1310110062#
name: malate dehydrogenase, mitochondrial
modifier: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_89ba682a_26ff_468a_9dd3_b47694ae328b
has only substance units: false
boundary condition: true
is encoded by: hsa:2819
name: GPD1
initial concentration: NaN
is: F8W1L5
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_bc619abf_7613_4131_aefb_c746c7708629
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:7390
boundary condition: true
is: P10746
name: UROS
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
fast: false
name: blood group intracellular transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#

metaM ksi pre25 g
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00175
constant: false
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: SBO:0000247
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 25
is: C00130
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_39071e53_0f6c_4315_bcea_c6b66bd80a78
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: B7Z7I0
is encoded by: hsa:8277
type: Species
name: TKTL1
constant: false

metaR PHEMEtm
kinetic law: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
name: Heme transport to cytosol
fast: false
product: MODEL1310110062#

metaR r1660
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110062#
fast: false
reversible: true
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_6d78e51c_fc50_446b_ba4d_9ebfa78203e1
initial amount: NaN
type: Species
name: PDE8A
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110062#_0175214f_3ca5_4dd4_9948_14219921696a
name: SLC24A3
type: Species
initial concentration: NaN
is encoded by: hsa:57419
boundary condition: true
is: Q9HC58
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_1e7725fc_695f_4b11_af40_12160e39ad75
is: P53602
boundary condition: true
is encoded by: hsa:4597
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: MVD
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_25af28d5_2f8e_42fb_92ca_ed41c10e51cf
is encoded by: hsa:5291
boundary condition: true
initial amount: NaN
has part: B3KT19
initial concentration: NaN
is: SBO:0000297
has part: B4DER4
has only substance units: false
constant: false
is encoded by: hsa:5295
type: Species
name: PIK3CB:PIK3R1

metaR BAAT4x
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000176
name: bile acid Coenzyme A: amino acid N-acyltransferase
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_9a907165_8a64_4f4c_81ce_eff40f906adb
name: ALDH1A3
constant: false
is: P47895
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:220
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR EX ddece1crn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaR GACPAILter
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
name: glucosaminyl-acylphosphatidylinositol ER flippase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
constant: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: CHEBI:61648

http://identifiers.org/biomodels.db/MODEL1310110062#_b39d8eef_df01_4ab2_8eea_20e23aabcb71
type: Species
name: _H77542_1_c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:H77542
constant: false
has only substance units: false

metaR FAOXC122C101m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaM HC00319 c
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
is: CHEBI:30794
name: Malonate
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM gly m
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
initial concentration: 1.0
type: Species
name: Glycine
constant: false
is: C00037
has only substance units: false
boundary condition: false
is: HMDB00123
initial amount: NaN
is: SBO:0000247

metaR r1912
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
name: Y+LAT2 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_e7a0206b_156b_4bd8_a762_9516d8ea8c1b
is encoded by: hsa:10400
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: PEMT
boundary condition: true
initial amount: NaN
is: Q9UBM1

metaR GALASE6ly
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
name: beta-galactosidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110062#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_9490aa10_88fd_4e27_b559_c226e284570b
has only substance units: false
is encoded by: hsa:5831
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: PYCR1
is: A6NFM2
initial amount: NaN
boundary condition: true

metaM adn e
initial amount: NaN
is: C00212
is: SBO:0000247
name: Adenosine
type: Species
initial concentration: 1.0
is: HMDB00050
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212

http://identifiers.org/biomodels.db/MODEL1310110062#_6f66c98e_fd4b_45a0_a2bb_ea94a9c0ee7e
name: DGKI
constant: false
is: O75912
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9162

http://identifiers.org/biomodels.db/MODEL1310110062#_d83341a6_cb60_41ba_8438_4ad4ce4e4147
is encoded by: hsa:5139
boundary condition: true
is: Q14432
initial concentration: NaN
name: PDE3A
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaM xol7aone m
is: CHEBI:17899
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
type: Species

metaM tettet6 c
name: tetracosatetraenoic acid n-6
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
is: HMDB06246
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_fd633495_af08_468c_8f7b_68e2626c7043
constant: false
is: SBO:0000252
is encoded by: hsa:AU149534
boundary condition: true
initial concentration: NaN
name: _AU149534_1_c
initial amount: NaN
type: Species
has only substance units: false

metaM strdnc e
has only substance units: false
initial amount: NaN
constant: false
is: HMDB06547
type: Species
initial concentration: 1.0
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: SBO:0000247
boundary condition: false
name: stearidonic acid C18:4, n-3
is: C16300
is: http://identifiers.org/pubchem.compound/47205608

metaM pydxn c
name: Pyridoxine
constant: false
is: SBO:0000247
is: HMDB00239
has only substance units: false
initial amount: NaN
is: C00314
is: CHEBI:16709
type: Species
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
boundary condition: false
initial concentration: 1.0

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_d0b8177d_bf59_450f_be7c_cc9eb21ad2cb
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4832
is: Q13232
name: NME3
is: SBO:0000252
type: Species
boundary condition: true

metaR PROGLYPRO1c
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of glycylproline in the small intestine for cellular uptake
type: Reaction

metaM uacgam c
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: CHEBI:57705
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00290
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c870a5be_62fd_493d_be0f_a39b4660b4eb
is: Q86SK9
is encoded by: hsa:79966
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SCD5
type: Species
boundary condition: true

metaM kdnp c
is: CHEBI:17369
boundary condition: false
is: SBO:0000247
is: HMDB01078
notes: FORMULA: C9H14O12P CHARGE: -3
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate
type: Species

metaM pail5p hs c
is: CHEBI:57795
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN

metaM hexdicoa c
is: HMDB02014
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
constant: false
name: hexadecanedioylcoa

metaR r0531
product: MODEL1310110062#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_2da9d2aa_441d_412f_b968_ba6585be85fe
is: P20674
has only substance units: false
initial amount: NaN
name: COX5A
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9377
type: Species
is: SBO:0000252

metaM adn c
name: Adenosine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: HMDB00050
is: CHEBI:16335
is: C00212
is: SBO:0000247
constant: false

metaR G14T13g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is: SBO:0000176
reactant: MODEL1310110062#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_9eddf1c7_2e08_42b1_be94_73aa76dc4896
is: P56181
constant: false
is encoded by: hsa:4731
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: NDUFV3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_71a95aff_8ffa_45db_978c_db65071d9444
is: A0PJJ9
type: Species
has only substance units: false
constant: false
name: GGT7
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2686
initial amount: NaN
boundary condition: true

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaM tettet6 e
name: tetracosatetraenoic acid n-6
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
is: HMDB06246

http://identifiers.org/biomodels.db/MODEL1310110062#_ce237bde_daf9_4599_b407_60947a1a9f8b
boundary condition: true
constant: false
is: Q15147
type: Species
is encoded by: hsa:5332
is: SBO:0000252
name: PLCB4
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM HC00591 m
initial concentration: 1.0
type: Species
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: 2-oxoglutaramate
is: CHEBI:16769
boundary condition: false

metaM occoa m
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C01944
boundary condition: false
is: HMDB01070
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386

metaR GALASE9ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110062#

metaM hpdcacrn m
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
initial amount: NaN
has only substance units: false
name: heptadecanoyl carnitine
is: SBO:0000247
is: HMDB06210
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

metaR CRVNCtr
product: MODEL1310110062#
reactant: MODEL1310110062#
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_7c91929e_51b8_41aa_8c02_d8061a1406ea
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:80271
initial concentration: NaN
name: ITPKC
is: Q96DU7
initial amount: NaN
is: SBO:0000252

metaR LTD4DP
fast: false
reversible: true
kinetic law: MODEL1310110062#
name: Leukotriene D4 dipeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110062#
type: Reaction

metaM thr L c
constant: false
is: SBO:0000247
is: HMDB00167
is: CHEBI:16857
type: Species
has only substance units: false
name: L-threonine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179

http://identifiers.org/biomodels.db/MODEL1310110062#_eb2e675d_1d7b_4fb5_9c66_fc9e358d2102
type: Species
is encoded by: hsa:55650
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q9NUD9
initial amount: NaN
name: PIGV
has only substance units: false

metaR BUTt2r
is described by: ECO:0000269
modifier: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
type: Reaction
fast: false
is: SBO:0000185
name: Butyrate transport via proton symport, reversible

metaR DUDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reactant: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
name: dUDP nuclear transport
product: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR DOPAtu
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
name: Dopamine uniport
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#

metaM tdchola x
type: Species
initial concentration: 1.0
is: HMDB00951
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
name: taurochenodeoxycholate
is: CHEBI:9407
is: SBO:0000247

metaR RE1897C
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
name: RE1897
kinetic law: MODEL1310110062#
is: SBO:0000176
reversible: true
type: Reaction

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR r0523
is version of: http://identifiers.org/ec-code/1.17.4.1
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
reversible: false

metaR DCMPDA
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.12
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110062#
is described by: ECO:0000254
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: dCMP deaminase

metaM prpp c
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: C00119
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58017
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false

metaR CYTK2n
modifier: MODEL1310110062#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP),nuclear
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_546a0a74_15c1_4da8_b99d_273c16610cc6
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:25769
is: Q9UI40
has only substance units: false
name: SLC24A2
is: SBO:0000252

metaR HMGCOASim
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Hydroxymethylglutaryl CoA synthase (ir)
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is described by: ECO:0000269
modifier: MODEL1310110062#
product: MODEL1310110062#

metaR SPMS
reversible: false
is described by: ECO:0000269
name: spermidine synthase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.5.1.16
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
reactant: MODEL1310110062#
type: Reaction

metaM thr L e
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00167
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
boundary condition: false
is: CHEBI:16857
is: SBO:0000247
name: L-threonine
type: Species
has only substance units: false

metaR ALACYSNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
fast: false
kinetic law: MODEL1310110062#
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#

metaR 5ADTSTSTERONEtr
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: 5 alpha dihydrotesterone intracellular transport
reversible: true
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110062#

metaM 3tetd7ecoa c
type: Species
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
boundary condition: false
is: HMDB05066
name: 3-hydroxy tetradecenoyl-7-coa
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR THYOXt
modifier: MODEL1310110062#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
fast: false
name: T4 transport via bicarbonate countertransport
kinetic law: MODEL1310110062#
product: MODEL1310110062#

metaM uacgam g
type: Species
is: SBO:0000247
boundary condition: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
is: CHEBI:57705
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
is: HMDB00290
constant: false

metaM lthstrl r
is: CHEBI:17168
boundary condition: false
is: HMDB01170
constant: false
name: 5alpha-cholest-7-en-3beta-ol
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189

metaM glyb c
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00043
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species
name: glycine betaine

http://identifiers.org/biomodels.db/MODEL1310110062#_d236debc_b181_4671_8eb3_e29ec38612ab
boundary condition: true
constant: false
is: Q9NPB1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NT5M
is encoded by: hsa:56953
type: Species
initial amount: NaN

metaR GTHDH
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
reversible: false
is described by: ECO:0000134
name: Glutathione dehydrogenase (dehydroascorbate reductase)
reactant: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
type: Reaction
fast: false
product: MODEL1310110062#

metaR r0522
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
type: Reaction
is described by: ECO:0000000
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
modifier: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
is: SBO:0000176

metaM oaa m
has only substance units: false
is: SBO:0000247
is: C00036
constant: false
is: HMDB00223
boundary condition: false
is: CHEBI:16452
name: Oxaloacetate
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_9e3b4150_faac_43ce_91b3_22c9df9ff3f5
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: _AA854479_1_m
boundary condition: true
is encoded by: hsa:AA854479

http://identifiers.org/biomodels.db/MODEL1310110062#_b63ddfc0_aa3a_4368_b88e_0a61d3c898de
boundary condition: true
is encoded by: hsa:2678
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: GGT1
constant: false

metaM octa c
initial amount: NaN
boundary condition: false
is: CHEBI:25646
name: octanoate (n-C8:0)
is: C06423
is: SBO:0000247
notes: FORMULA: C8H15O2 CHARGE: -1
is: HMDB00482
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR RE2974N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
is described by: ECO:0000000
fast: false
name: RE2974
reactant: MODEL1310110062#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#

metaM dhf m
constant: false
is: CHEBI:57451
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
name: dihydrofolate(2-)
initial concentration: 1.0

metaR GLUPRT
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.2.14
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
modifier: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
name: glutamine phosphoribosyldiphosphate amidotransferase
reversible: false
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_cd1f9989_25d7_4694_8507_ec9a0fa8356c
initial concentration: NaN
is encoded by: hsa:3948
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: LDHC
type: Species
is: P07864

metaR RAI1
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
name: retinal isomerase (11-cis)
reversible: true
reactant: MODEL1310110062#
is: SBO:0000176
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#

metaM prpp e
is: CHEBI:58017
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
constant: false
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00280
initial concentration: 1.0
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_1856c155_d3cc_48c8_891f_2e84d29a7328
is: P48728
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: AMT
is: SBO:0000252
is encoded by: hsa:275

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_468af175_111d_4a1c_a768_1bd5464bb52f
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:7378
has only substance units: false
name: UPP1
initial concentration: NaN
is: SBO:0000252

metaR r1768
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#
name: Y+LAT2 Utilized transport
type: Reaction

metaR RE2269E
name: RE2269
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is version of: http://identifiers.org/ec-code/3.4.21.39
product: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_6cf7391f_f612_479c_bac3_4ed3bb71653a
is: SBO:0000252
type: Species
initial concentration: NaN
name: GALNT10
boundary condition: true
is encoded by: hsa:55568
initial amount: NaN
has only substance units: false
constant: false

metaM ametam c
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
constant: false
is: C01137
initial amount: NaN
has only substance units: false
name: S-Adenosylmethioninamine
is: CHEBI:57443
initial concentration: 1.0
is: HMDB00988
boundary condition: false
type: Species
is: SBO:0000247

metaR EX urea LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urea exchange
type: Reaction

metaR GCCbim
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
fast: false
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM glx c
is: CHEBI:36655
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
name: glyoxylate
initial amount: NaN
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119

metaR CSND
name: Cytosine deaminase
reversible: false
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
is described by: ECO:0000000
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_d25327ff_01f1_4acb_8d03_6d366364bcc0
has only substance units: false
is encoded by: hsa:6319
constant: false
initial amount: NaN
boundary condition: true
name: SCD
initial concentration: NaN
is: O00767
is: SBO:0000252
type: Species

metaM octa e
boundary condition: false
is: CHEBI:25646
is: C06423
is: SBO:0000247
name: octanoate (n-C8:0)
constant: false
is: HMDB00482
notes: FORMULA: C8H15O2 CHARGE: -1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR PI4PLC
modifier: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110062#
fast: false
type: Reaction
reactant: MODEL1310110062#
name: phosphatidylinositol 4-phosphate phospholipase C
kinetic law: MODEL1310110062#
reversible: false

metaR UPP3S
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.75
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
reactant: MODEL1310110062#
name: uroporphyrinogen-III synthase
fast: false
product: MODEL1310110062#

metaR BACCLm
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000254
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_f7f2fe62_66f4_4e43_8270_6a45e7b1bbd6
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:516
initial concentration: NaN
constant: false
has only substance units: false
name: ATP5G1
is: Q6FIH7

http://identifiers.org/biomodels.db/MODEL1310110062#_6c37c93f_e03c_487d_8eea_4944fe652904
is: SBO:0000252
type: Species
is encoded by: hsa:160287
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: LDHAL6A
constant: false
is: Q6ZMR3

metaR EX c10dc
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sebacoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_4f20bd3a_358f_4633_84f8_baf70f082b04
is: Q9NRA2
is encoded by: hsa:26503
has only substance units: false
name: SLC17A5
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_9b3145a2_84d4_4c06_9d85_e3c84f9eebe7
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PDE8A
constant: false
initial concentration: NaN
is encoded by: hsa:5151
is: O60658
type: Species
initial amount: NaN

metaR r0527
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is: SBO:0000176
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_632b7d85_6764_4c26_8c12_358bb8d9553f
boundary condition: true
initial concentration: NaN
name: ENTPD1
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:953
is: Q86VV3
has only substance units: false

metaM ksi deg9 l
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00143
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 9
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
type: Species

metaR LTA4H
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.3.2.6
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: Leukotriene A-4 hydrolase
kinetic law: MODEL1310110062#
reversible: false
is described by: ECO:0000134
product: MODEL1310110062#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110062#_cd17748b_396d_4a9d_9240_c62544ed1645
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AI480132_1_c
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI480132

http://identifiers.org/biomodels.db/MODEL1310110062#_5292aa16_fa5b_460c_9d82_3469bdefddaa
boundary condition: true
is: SBO:0000252
is encoded by: hsa:R51273
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: _R51273_1_c

http://identifiers.org/biomodels.db/MODEL1310110062#_d6daf750_b7be_4843_8c29_611f368316f8
is encoded by: hsa:4709
is: SBO:0000252
is: Q6IB80
has only substance units: false
boundary condition: true
initial amount: NaN
name: NDUFB3
initial concentration: NaN
constant: false
type: Species

metaM dcholcoa x
initial concentration: 1.0
type: Species
is: CHEBI:28701
name: chenodeoxycholoyl coenzyme a
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
has only substance units: false
initial amount: NaN

metaR DURIt
type: Reaction
fast: false
product: MODEL1310110062#
name: deoxyuridine transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
reactant: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#

metaR ITCOALm
kinetic law: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_c9cf53c0_feca_43cb_8fba_b49cca1b89aa
boundary condition: true
constant: false
type: Species
has only substance units: false
name: AK7
initial amount: NaN
is: Q96M32
is: SBO:0000252
is encoded by: hsa:122481
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_a12d7cf9_a634_4514_800c_aca0a5c5d2ec
has only substance units: false
type: Species
boundary condition: true
name: SLC25A1
is: D9HTE9
is encoded by: hsa:6576
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_ef2bb820_8428_4f14_8fce_abe62d47d8bc
initial concentration: NaN
initial amount: NaN
is: Q9BZQ4
name: NMNAT2
has only substance units: false
is encoded by: hsa:23057
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaR DOLPGT2 Ler
modifier: MODEL1310110062#
reversible: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.265
fast: false
is: SBO:0000176

metaM dd2coa c
name: trans-Dodec-2-enoyl-CoA
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB03712
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_594a66e7_bc64_436d_b86c_c0c66b6815e8
is: Q96I99
type: Species
is encoded by: hsa:8801
name: SUCLG2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
product: MODEL1310110062#
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110062#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: true
is: SBO:0000185

metaR r2141
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#

metaR ARSA
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
kinetic law: MODEL1310110062#
reversible: false
name: Arylsulfatase A
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110062#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.8

http://identifiers.org/biomodels.db/MODEL1310110062#_a5a59280_a6ff_4507_90f1_d1c9cd702dac
has only substance units: false
is: SBO:0000252
is encoded by: hsa:215
type: Species
initial amount: NaN
name: ABCD1
boundary condition: true
constant: false
is: P33897
initial concentration: NaN

metaR RE3269C
reversible: true
fast: false
product: MODEL1310110062#
name: RE3269
is version of: http://identifiers.org/ec-code/3.1.3.48
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
modifier: MODEL1310110062#

metaR O2ter
product: MODEL1310110062#
name: O2 transport, endoplasmic reticulum
fast: false
reactant: MODEL1310110062#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#

metaR C101CRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR URIt5le
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: uridine transport in via sodium symport (1:2)
type: Reaction
modifier: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
reversible: false
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_f6ce8814_4762_4421_82ea_e9982ee9f46c
name: SLC5A3
type: Species
initial concentration: NaN
is encoded by: hsa:6526
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P53794
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_cca380b9_456f_4895_8e38_fb49af09ef28
is encoded by: hsa:314
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: AOC2
constant: false
boundary condition: true
initial concentration: NaN

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR ILETAm
fast: false
is: SBO:0000176
name: isoleucine transaminase, mitochondrial
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
type: Reaction
reversible: true

metaM sbcoa c
is: SBO:0000247
boundary condition: false
name: suberylcoa
is: C02838
is: HMDB00791
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM ala D e
initial amount: NaN
is: SBO:0000247
constant: false
name: D-alanine
is: HMDB01310
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
is: CHEBI:15570
initial concentration: 1.0
has only substance units: false

metaR r2140
modifier: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_0f3c1dc8_47ba_4892_9c33_c4ccf56c030b
is encoded by: hsa:55825
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PECR
initial amount: NaN
type: Species
constant: false
is: Q9BY49

metaR FERO
modifier: MODEL1310110062#
reversible: false
name: ferroxidase
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000134
type: Reaction

metaR KCCt
is: SBO:0000185
is described by: ECO:0000269
fast: false
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
name: K+-Cl- cotransport
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
type: Reaction
modifier: MODEL1310110062#

metaR r0652
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
reactant: MODEL1310110062#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
product: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_acc9a192_cbdf_467c_abb3_73e602edec29
is: P19440
is: SBO:0000252
name: GGT1
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:2678
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_acgalfucgalacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:61648
initial amount: NaN
constant: false
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
initial concentration: 1.0
notes: FORMULA: C72H125N4O41FULLRCO CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_fde43c34_8c01_465a_8a5d_4e039d62f972
name: ELOVL1
boundary condition: true
is: Q9BW60
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:64834
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM 3tetd7ecoa m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
constant: false
name: 3-hydroxy tetradecenoyl-7-coa
initial amount: NaN
type: Species
is: HMDB05066
has only substance units: false
is: SBO:0000247

metaR FRUt4
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
name: D-fructose transport via sodium cotransport
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false

metaR S23Tg
type: Reaction
reversible: false
reactant: MODEL1310110062#
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
modifier: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:15347
name: Type IIIA glycolipid
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
initial amount: NaN
is: HMDB01659

metaR GLNtm
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
name: L-glutamine transport via electroneutral transporter
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)

metaR S4TASE5ly
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110062#
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_3f6f86d7_8ade_4d99_99ca_3dc8d5a3854c
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: FOLR1
is encoded by: hsa:2348
boundary condition: true

metaR r0651
modifier: MODEL1310110062#
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_04b998a9_30ae_4621_afd5_36df2ccb2dc4
type: Species
is: SBO:0000252
is encoded by: hsa:51805
boundary condition: true
constant: false
is: Q9NZJ6
has only substance units: false
name: COQ3
initial concentration: NaN
initial amount: NaN

metaR r2142
is described by: ECO:0000000
modifier: MODEL1310110062#
reversible: true
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110062#
type: Reaction

metaM docohexcoa m
constant: false
name: 2,4,7,10,13,16-docosahexenoylcoa
is: HMDB06294
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM ala D c
is: HMDB01310
is: CHEBI:15570
initial concentration: 1.0
name: D-alanine
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaR GLUTCOAACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaM cpppg3 c
constant: false
initial concentration: 1.0
is: CHEBI:57309
is: C03263
type: Species
has only substance units: false
is: HMDB01261
initial amount: NaN
is: SBO:0000247
name: Coproporphyrinogen III
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9a55eef6_ff90_4be6_81f4_8cc6e35c3399
boundary condition: true
name: CPOX
has only substance units: false
constant: false
is encoded by: hsa:1371
is: P36551
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM CE5120 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57923
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: trans-2-cis-8-tetradecadienoyl-CoA

metaR HISSNAT5tc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR LNLNCACRNt
type: Reaction
product: MODEL1310110062#
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000269

metaR r0389
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
reversible: true
reactant: MODEL1310110062#
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
type: Reaction

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR RE1526M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110062#
type: Reaction
reversible: true
name: RE1526
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#

metaM HC01118 r
constant: false
type: Species
name: presqualene diphosphate(3-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57310
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428

http://identifiers.org/biomodels.db/MODEL1310110062#_66a98c88_eddc_43fb_b5ba_cc6532419823
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC7A7
is encoded by: hsa:9056
constant: false
boundary condition: true
is: Q9UM01
type: Species

metaR NDP8ex
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
name: nucleoside-diphosphatase (UTP), extracellular
kinetic law: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
reversible: false

metaM ru5p D c
initial amount: NaN
is: HMDB00618
initial concentration: 1.0
type: Species
name: D-ribulose 5-phosphate(2-)
has only substance units: false
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: SBO:0000247
boundary condition: false
constant: false

metaM 34dhmald c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: 3,4-Dihydroxymandelaldehyde
is: http://identifiers.org/pubchem.compound/7903
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
type: Species
is: C05577

metaR RE2974C
modifier: MODEL1310110062#
name: RE2974
is version of: http://identifiers.org/ec-code/2.7.1.149
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_44eeb455_cf59_47ee_bd14_2b058e2d6cd4
initial concentration: NaN
is encoded by: hsa:112
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: ADCY6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
is: SBO:0000247
is: CHEBI:57847
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00304
boundary condition: false
initial amount: NaN
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
name: Type IIIA glycolipid
constant: false

metaR DHCRD1
type: Reaction
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
reactant: MODEL1310110062#
reversible: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110062#
is: SBO:0000176
name: dihydroceramide desaturase

http://identifiers.org/biomodels.db/MODEL1310110062#_f5d203e5_b740_4db1_8a1a_6234dff03138
has only substance units: false
boundary condition: true
is encoded by: hsa:1119
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: CHKA
type: Species

metaR N4Tg
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_19f38611_25b0_4bce_83f5_f470db976d97
name: _AL525798_1_c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AL525798
constant: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_072a647e_1129_460d_8d0c_5ce052547687
initial amount: NaN
has only substance units: false
is encoded by: hsa:23007
is: Q4KWH8
type: Species
boundary condition: true
is: SBO:0000252
name: PLCH1
initial concentration: NaN
constant: false

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM dhf c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C00415
constant: false
name: 7,8-Dihydrofolate
is: SBO:0000247
is: HMDB01056
has only substance units: false
type: Species
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

http://identifiers.org/biomodels.db/MODEL1310110062#_1999dced_f517_4981_bee6_07fdcba61018
is encoded by: hsa:5167
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: P22413
boundary condition: true
initial concentration: NaN
name: ENPP1
is: SBO:0000252

metaR r0388
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
reversible: true
reactant: MODEL1310110062#
fast: false

metaR UDPtl
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110062#
type: Reaction
name: udp intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#

metaR r0653
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110062#_4a89e576_ef7a_4761_9ba6_1ab3559dca0b
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:57665
constant: false
is: Q9HBH5
name: RDH14
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_b75904d7_0349_4203_84ce_fb2933da670a
initial amount: NaN
initial concentration: NaN
is: Q9Y6M9
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:4715
name: NDUFB9
type: Species

metaR 4NPHSULT
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.1
name: 4-Nitrophenol Sulfotransferase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR FUT911g
modifier: MODEL1310110062#
name: Alpha-(1,3)-fucosyltransferase
kinetic law: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.152
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
reactant: MODEL1310110062#
reversible: false
is described by: ECO:0000269
is: SBO:0000176

metaM oaa c
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: HMDB00223
is: CHEBI:3338
is: C00036
name: Oxaloacetate
notes: FORMULA: C4H2O5 CHARGE: -2
initial concentration: 1.0
constant: false

metaR BHBtm
reversible: true
reactant: MODEL1310110062#
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is described by: ECO:0000000
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
kinetic law: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_a39f1445_7fe7_4bd4_b03c_61eef665613a
is: P31639
type: Species
boundary condition: true
is encoded by: hsa:6524
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: SLC5A2
has only substance units: false

metaM mi1p D n
has only substance units: false
name: 1D-myo-inositol 1-phosphate(2-)
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: HMDB02985
is: CHEBI:58433
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial concentration: 1.0

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_10bda732_92a5_4864_a384_09c944b52bd7
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: HSD11B1
constant: false
is: SBO:0000252
is encoded by: hsa:3290
has only substance units: false
type: Species

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR RE0453N
name: RE0453
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction

metaR HMGLm
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.3.4
name: hydroxymethylglutaryl-CoA lyase
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
reversible: false
modifier: MODEL1310110062#
is described by: ECO:0000134
fast: false

metaR UMPKn
type: Reaction
modifier: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
name: UMP kinase, nuclear

metaR RE2079R
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: RE2079
reactant: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR THRGLNNaEx
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000269
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110062#
fast: false
is: SBO:0000185

metaM nrpphr e
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
is: SBO:0000247
is: HMDB00216
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:33569

http://identifiers.org/biomodels.db/MODEL1310110062#_cc63c802_d1f3_4b64_b641_72d43955fb30
constant: false
name: PRDX1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5052

metaR PGLer
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
fast: false
product: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110062#
name: 6-phosphogluconolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD

metaR GLNS
fast: false
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: glutamine synthetase
is: SBO:0000176
modifier: MODEL1310110062#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/4.1.1.15

http://identifiers.org/biomodels.db/MODEL1310110062#_47b69005_1a5e_4455_832e_5faf425c9e0d
is encoded by: hsa:1798
initial concentration: NaN
constant: false
name: DPAGT1
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaM c14dccoa x
is: SBO:0000247
initial amount: NaN
name: tetradecanedioylcoa
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02288
constant: false

metaR RE3244R
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: RE3244
reversible: true
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR MALSO3tm
name: Malate:sulfite antiport, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000269
reversible: true
type: Reaction

metaM HC00319 m
initial amount: NaN
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
name: Malonate
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:30794

metaR ACACt2m
name: Acetoacetate mitochondrial transport via H+ symport
kinetic law: MODEL1310110062#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_84eff15d_f69e_43a1_8c04_e2c523f840ad
boundary condition: true
initial concentration: NaN
is: F5GZG6
initial amount: NaN
is encoded by: hsa:27010
is: SBO:0000252
constant: false
name: TPK1
has only substance units: false
type: Species

metaR r1659
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r0650
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110062#
reversible: true
fast: false
reactant: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
type: Reaction
is described by: ECO:0000000

metaR CSAPASEly
is: SBO:0000176
reversible: false
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
is described by: ECO:0000000
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#

metaR NAtx
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
fast: false
reversible: true
product: MODEL1310110062#
name: sodium transport via diffusion (perioxisome)
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR S6T16g
kinetic law: MODEL1310110062#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is: SBO:0000176
fast: false
reversible: false

metaR UMPK6n
product: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
is described by: ECO:0000269
name: UMP kinase (dCTP),nuclear
modifier: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
name: Type IIIA glycolipid
has only substance units: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: HMDB01659
boundary condition: false
is: SBO:0000247
is: CHEBI:15347
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_733fa372_e447_467c_9911_0d09be9921a4
name: TH
initial concentration: NaN
is: P78428
boundary condition: true
is encoded by: hsa:7054
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM nrpphr c
is: SBO:0000247
initial amount: NaN
is: CHEBI:33569
type: Species
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00216

http://identifiers.org/biomodels.db/MODEL1310110062#_239684d6_8a00_4d93_9f19_5f269ad6274b
boundary condition: true
constant: false
is encoded by: hsa:594
type: Species
is: Q9BQL0
initial concentration: NaN
has only substance units: false
name: BCKDHB
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_600446b8_96a8_40d4_a608_e64a75f32fd3
boundary condition: true
name: VNN3
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55350

metaR PYDAMK
is version of: http://identifiers.org/ec-code/2.7.1.35
name: pyridoxamine kinase
product: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_bf7148b8_6605_4bdd_a2ee_b77702d5621d
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3636
has only substance units: false
name: INPPL1
boundary condition: true
is: O15357
is: SBO:0000252

metaR r0384
kinetic law: MODEL1310110062#
reversible: false
product: MODEL1310110062#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
reactant: MODEL1310110062#
fast: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2

metaM pdx5p c
has only substance units: false
initial amount: NaN
is: HMDB01319
is: SBO:0000247
name: Pyridoxine 5'-phosphate
constant: false
is: CHEBI:58589
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
type: Species
initial concentration: 1.0
boundary condition: false
is: C00627

metaR DHPM1
kinetic law: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
modifier: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.2.2
reactant: MODEL1310110062#
fast: false
name: dihydropyrimidinase (5,6-dihydrouracil)

metaR r2443
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110062#
type: Reaction
fast: false
reversible: false
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110062#

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

metaR RE3628M
is: SBO:0000176
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
name: RE3628
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM HC01610 e
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
constant: false
is: CHEBI:28607
name: CoproporphyrinogenI
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_41fc734e_82d9_427c_9054_fa7fc6a10a37
type: Species
initial concentration: NaN
name: CPT1B
boundary condition: true
has only substance units: false
is encoded by: hsa:1375
constant: false
is: SBO:0000252
initial amount: NaN
is: B7Z5T8

metaM CE0849 m
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57795
is: SBO:0000247
type: Species
has only substance units: false
name: cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849

metaR r2380
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM galthcrm hs g
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:26174
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0
name: Gal-Gal-Gal-Glc-Cer

http://identifiers.org/biomodels.db/MODEL1310110062#_3cd895a9_f19a_4e36_9ae9_aa72ba078660
is: P30838
is encoded by: hsa:218
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: ALDH3A1
is: SBO:0000252
boundary condition: true

metaR r0425
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
name: EC:1.1.1.42
kinetic law: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#

metaM dcsptn1crn m
is: SBO:0000247
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
initial concentration: 1.0
is: HMDB06321
constant: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false
initial amount: NaN
has only substance units: false

metaM lnlncacrn c
name: alpha-linolenyl carnitine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06319
boundary condition: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110062#_bbe50b43_945d_46d4_a97f_6ba341fe08b7
initial amount: NaN
is encoded by: hsa:79369
is: Q9C0J1
name: B3GNT4
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR DOLPMT3 Ler
reversible: false
reactant: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.260
type: Reaction
product: MODEL1310110062#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
fast: false
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR r2036
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110062#
fast: false
modifier: MODEL1310110062#

metaM pyam5p c
is: CHEBI:58451
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
initial concentration: 1.0
name: Pyridoxamine 5'-phosphate
constant: false
is: SBO:0000247
is: C00647
is: HMDB01555
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaM ahcys e
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
has only substance units: false
is: C00021
is: HMDB00939
boundary condition: false
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16680
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_26db158a_19ec_4efd_9ebc_cb3a43aa67a1
has only substance units: false
boundary condition: true
is: P35557
initial amount: NaN
is: SBO:0000252
constant: false
name: GCK
initial concentration: NaN
type: Species
is encoded by: hsa:2645

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_273162ae_b204_4da2_afeb_fd6b4600e926
constant: false
is encoded by: hsa:48
initial concentration: NaN
name: ACO1
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is: P21399
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_f14a2790_d73d_42cc_a30b_f0f82b84424c
initial concentration: NaN
is: P50993
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: ATP1A2
type: Species
is: SBO:0000252
is encoded by: hsa:477

metaR SUCCACT
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR r0365
is: SBO:0000176
fast: false
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_1b169f5a_c8d8_4f7d_929d_e0c6ce14bb71
is: E7EPA7
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: TKT
is encoded by: hsa:7086

http://identifiers.org/biomodels.db/MODEL1310110062#_c5b20bc2_410c_4d9d_9c7f_1a31ee3638f5
name: FPGT
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:8790
is: O14772
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_e737c518_9c92_4cf6_97b0_f0b2f408f758
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: A0S0A7
initial amount: NaN
name: NOS3
boundary condition: true
is encoded by: hsa:4846
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_2de068ce_76a5_451e_8045_c1c40bf7d8b9
has only substance units: false
is: B7Z3W8
initial concentration: NaN
boundary condition: true
name: SLC6A9
initial amount: NaN
type: Species
is encoded by: hsa:6536
constant: false
is: SBO:0000252

metaR GALT
is: SBO:0000176
product: MODEL1310110062#
name: galactose-1-phosphate uridylyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
kinetic law: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000

metaM akg m
is: SBO:0000247
name: 2-Oxoglutarate
is: CHEBI:16810
initial amount: NaN
has only substance units: false
is: C00026
is: HMDB00208
boundary condition: false
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
constant: false

metaR r0426
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000176
fast: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
product: MODEL1310110062#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.34

http://identifiers.org/biomodels.db/MODEL1310110062#_29cd4d17_858c_424e_a4d1_f19994d25f5d
is encoded by: hsa:2597
type: Species
initial amount: NaN
is: E7EUT4
has only substance units: false
initial concentration: NaN
boundary condition: true
name: GAPDH
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_d918d19d_07ce_444b_a6ef_86d750c05c3f
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _M68895_1_c
constant: false
has only substance units: false
type: Species
is encoded by: hsa:M68895
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_b2fe3e86_0bf2_42d0_a02a_b5cc60a840b3
constant: false
initial amount: NaN
is encoded by: hsa:1808
is: B4DR31
initial concentration: NaN
name: DPYSL2
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_1bf4f82f_6095_4f03_8186_72a26c2b9763
constant: false
is: SBO:0000252
is encoded by: hsa:4712
has only substance units: false
initial concentration: NaN
name: NDUFB6
initial amount: NaN
boundary condition: true
type: Species
is: O95139

metaR FAOXC102C101m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR r0974
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is described by: ECO:0000000
reversible: true
name: Active transport
fast: false
is: SBO:0000185
product: MODEL1310110062#

metaM sphmyln hs c
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial amount: NaN
name: sphingomyelin betaine
is: SBO:0000247
constant: false
is: CHEBI:58216
type: Species

metaR C102CPT1
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR r2382
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false

metaM forglu c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:18327
constant: false
is: C00439
is: HMDB00854
has only substance units: false
is: SBO:0000247
name: N-Formimidoyl-L-glutamate
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
type: Species

metaR NCNt
modifier: MODEL1310110062#
name: Na+/Ca2+-NH4+ exchange
reversible: true
kinetic law: MODEL1310110062#
fast: false
is described by: ECO:0000269
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR r2034
reactant: MODEL1310110062#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
fast: false
product: MODEL1310110062#

metaR TMDPK
reversible: false
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
is version of: http://identifiers.org/ec-code/2.7.6.2
product: MODEL1310110062#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110062#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_6b23bcee_397f_4dc5_8296_9d0aa5296d55
boundary condition: true
constant: false
is encoded by: hsa:26002
initial concentration: NaN
initial amount: NaN
type: Species
name: MOXD1
is: SBO:0000252
has only substance units: false
is: Q6UVY6

http://identifiers.org/biomodels.db/MODEL1310110062#_3950feab_6c41_46d0_91cd_f109d061a11c
initial amount: NaN
is: P48448
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: ALDH3B2
is encoded by: hsa:222
type: Species

metaR 13DAMPPOX
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
reversible: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000212
product: MODEL1310110062#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction

metaM ahcys c
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16680
is: C00021
boundary condition: false
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
name: S-Adenosyl-L-homocysteine

metaM dolmanp L c
is: CHEBI:15809
initial amount: NaN
boundary condition: false
name: Dolichyl phosphate D-mannose, human liver homolog
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR 34DHXMANDACOX NADP
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
reversible: true
product: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_f69ad1b0_0743_40e8_8a1f_a3e37e4345a4
boundary condition: true
type: Species
constant: false
name: NDUFA8
is: SBO:0000252
initial concentration: NaN
is: B1AM93
initial amount: NaN
is encoded by: hsa:4702
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_537cd998_c3a0_438c_a456_cedcb55e63ad
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:26289
initial concentration: NaN
name: AK5
constant: false

metaM ocdcea r
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
type: Species
constant: false
has only substance units: false
is: HMDB00207
name: octadecenoate (n-C18:1)
is: SBO:0000247
is: C00712
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_5bb105e4_6886_4146_82dc_3aaaccf4de93
constant: false
boundary condition: true
is: SBO:0000252
is: P07451
initial concentration: NaN
is encoded by: hsa:761
has only substance units: false
type: Species
initial amount: NaN
name: CA3

metaR r0975
kinetic law: MODEL1310110062#
fast: false
type: Reaction
product: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reactant: MODEL1310110062#
reversible: false
name: Facilitated diffusion

metaR TMDPP
reversible: true
name: thymidine phosphorylase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.4
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:

metaR r0360
product: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.16
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110062#
type: Reaction
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaM pail4p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
constant: false
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR SARCStex
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
type: Reaction
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Sarcosine transport (extracellular to cytosol)
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_de70f8fc_78bc_49b7_9b6e_1ad28a690175
boundary condition: true
constant: false
has only substance units: false
name: BAAT
is: Q14032
is encoded by: hsa:570
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaR ALOX52
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase

http://identifiers.org/biomodels.db/MODEL1310110062#_e8bb415c_c39c_4f63_a3e5_8b8ccd33c463
type: Species
has only substance units: false
initial concentration: NaN
name: FOLR1
is: SBO:0000252
is encoded by: hsa:2348
boundary condition: true
constant: false
initial amount: NaN

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_1483e777_4d7b_48be_8065_ed1e8d0820ab
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000297
has part: Q86U05
initial amount: NaN
is encoded by: hsa:23428
type: Species
has only substance units: false
name: SLC7A8:SLC3A2

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR IVCOAACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaR ALOX5
reversible: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
is: SBO:0000176
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
modifier: MODEL1310110062#
fast: false

metaR NACHEXA19ly
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false

metaM m6masnC g
notes: FORMULA: C58H97N2O45X CHARGE: 0
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:30825
type: Species
is: HMDB00573
is: SBO:0000247
initial amount: NaN
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false

metaR GLYCtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
name: glycerol transport
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110062#
type: Reaction

metaR RE2973C
type: Reaction
is: SBO:0000176
modifier: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.154
kinetic law: MODEL1310110062#
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR LNELDCCPT2
reactant: MODEL1310110062#
name: carnitine transferase
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM pe hs e
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038
name: phosphatidylethanolamine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_d634c434_8568_489c_a0a3_e05944dd3280
boundary condition: true
initial concentration: NaN
is: Q96FL9
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:79623
constant: false
name: GALNT14

metaR r0973
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Facilitated diffusion
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_91b6d407_1dd8_4af8_9263_30c96f89c6b0
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:1109
is: P17516
name: AKR1C4

metaM ddcacoa m
is: HMDB03571
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247
is: C01832
is: CHEBI:57375
type: Species
boundary condition: false
name: Dodecanoyl-CoA (n-C12:0CoA)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_3029854f_0b99_481e_bddd_234528e5a558
name: PRDX1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:5052

metaR C12OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaM ksii core2 pre2 g
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00175
type: Species
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 2
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: C00130

metaM sprm e
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:45725
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: HMDB01256
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
name: spermine(4+)

metaM CE2432 m
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
boundary condition: false
is: CHEBI:57795
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
has only substance units: false

metaM cspg a l
has only substance units: false
constant: false
is: HMDB02183
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36005
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
boundary condition: false

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR LNELDCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: carnitine O-palmitoyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000269

metaR TCHOLAte
type: Reaction
kinetic law: MODEL1310110062#
name: bile acid intracellular transport
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110062#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_eb2b062d_4bdd_4b99_b8bc_b7f057030eee
name: ATP5F1
is: SBO:0000252
is encoded by: hsa:515
is: Q08ET0
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_1c67316b_77b6_467a_9806_b5db8af04913
initial concentration: NaN
type: Species
name: CA2
boundary condition: true
is encoded by: hsa:760
is: P00918
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR r1527
is version of: http://identifiers.org/ec-code/4.2.1.1
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: SBO:0000185
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:

metaR H5MTer L
product: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
name: H5 mannosyltransferase, endoplasmic reticulum
type: Reaction
reversible: false
kinetic law: MODEL1310110062#

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_b7340706_65fd_4c74_8263_c5dc0d5160f6
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:522
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ATP5J
type: Species

metaM ptdcacrn m
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: pendtadenoyl carnitine
initial concentration: 1.0
has only substance units: false
is: CHEBI:18303
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
constant: false
type: Species

metaR KSII CORE4t
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110062#
reversible: false
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
name: keratan sulfate II (core4) transport, golgi to extracellular

metaR LEULEULAPc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaM HC02121 c
is: SBO:0000247
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
name: S-(hydroxymethyl)glutathione(1-)
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58758
constant: false
has only substance units: false
boundary condition: false

metaR LNLNCACPT2
kinetic law: MODEL1310110062#
name: carnitine transferase
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaM lnlncacrn m
name: alpha-linolenyl carnitine
has only substance units: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB06319
constant: false

metaM acgam6p c
has only substance units: false
is: HMDB01062
boundary condition: false
initial amount: NaN
is: CHEBI:57513
name: N-acetyl-D-glucosamine 6-phosphate(2-)
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
type: Species

metaR CYTK8
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (CMP,dATP)
product: MODEL1310110062#
modifier: MODEL1310110062#

metaM m7masnC g
boundary condition: false
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB06814
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial concentration: 1.0
constant: false
is: CHEBI:58401

http://identifiers.org/biomodels.db/MODEL1310110062#_1345cadb_f59c_46fd_b6a0_497653da8bbb
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: PDXK
is: O00764
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8566

metaM HC02175 c
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
has only substance units: false
constant: false
name: caprate
initial amount: NaN
is: CHEBI:27689
boundary condition: false
type: Species
initial concentration: 1.0

metaM omhpal c
initial concentration: 1.0
name: w-hydroxypalmiticacid
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C16H30O3 CHARGE: -1
type: Species
constant: false
is: HMDB06294

http://identifiers.org/biomodels.db/MODEL1310110062#_ed928c4b_5f88_45fe_8eee_9fb251480121
is encoded by: hsa:2182
is: SBO:0000252
constant: false
type: Species
is: O60488
initial amount: NaN
name: ACSL4
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR RE3273C
reversible: true
fast: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: RE3273
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.4.4

metaR r2388
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false
type: Reaction
reversible: false
product: MODEL1310110062#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110062#_d0d573cf_c21f_46ff_94b1_6bb7384d6766
has only substance units: false
initial amount: NaN
name: MVK
boundary condition: true
is: B2RDU6
is encoded by: hsa:4598
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_cb3c98b1_e4a9_4212_a978_f53e0bb96ce8
is: Q8NFL0
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:93010
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: B3GNT7

metaM fmn e
boundary condition: false
initial amount: NaN
is: C00061
name: FMN
has only substance units: false
notes: FORMULA: C17H19N4O9P CHARGE: -2
type: Species
is: HMDB01520
is: CHEBI:58210
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR FAOXC61m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR PGMT
is version of: http://identifiers.org/ec-code/5.4.2.2
is described by: ECO:0000134
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
is: SBO:0000176
name: phosphoglucomutase
fast: false
product: MODEL1310110062#

metaR r0145
fast: false
reactant: MODEL1310110062#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
type: Reaction
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.8.3.1
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
product: MODEL1310110062#

metaM sgalside hs c
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB03406
type: Species
initial concentration: 1.0
is: CHEBI:16523
boundary condition: false
name: sulfatide galactocerebroside
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110062#_89b0afa1_9232_4af9_a03a_543f65a52c74
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR CYTK9
type: Reaction
modifier: MODEL1310110062#
name: cytidylate kinase (CMP,dCTP)
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000269

metaM ksi deg30 l
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
constant: false
name: keratan sulfate I, degradation product 30
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00143
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110062#_5f64d086_b643_4431_9977_a0d80969f25e
has only substance units: false
constant: false
is encoded by: hsa:3030
name: HADHA
initial concentration: NaN
is: E9KL44
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR ADK3m
is described by: ECO:0000269
reactant: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
name: adentylate kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.10
fast: false
modifier: MODEL1310110062#
reversible: true
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_2e3a0d5e_7d18_463a_8e77_f364a74c01af
is: SBO:0000252
name: DPM3
has only substance units: false
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: Q9P2X0
is encoded by: hsa:54344
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_f5fe4151_06ee_40f7_957c_bbfee27a1788
is: SBO:0000252
name: GOT1
boundary condition: true
is: P17174
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:2805

metaR r2389
reversible: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110062#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110062#

metaR TYRTAm
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.5
modifier: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.6.1.1
name: tyrosine transaminase, mitochondrial
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110062#

metaR BTNt4i
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
name: Biotin uptake (antiport)
type: Reaction
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
is described by: ECO:0000269

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
is: CHEBI:32984

metaR ASNCYSNaEx
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
type: Reaction
reversible: false
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
product: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM pail5p hs n
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
is: CHEBI:57795

metaR RE2973N
modifier: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
name: RE2973
fast: false
reactant: MODEL1310110062#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176

metaR r0142
product: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false
reactant: MODEL1310110062#
is: SBO:0000176
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
fast: false
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:

metaM CE5160 r
is: SBO:0000247
initial amount: NaN
constant: false
name: 3-oxo-cis-9-octadecenoyl-CoA
has only substance units: false
is: CHEBI:57923
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
type: Species
initial concentration: 1.0
boundary condition: false

metaM HC02175 e
constant: false
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
name: caprate
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_6547824b_6769_4d47_a9bd_afff466af3e0
has only substance units: false
boundary condition: true
type: Species
name: SLC13A2
is encoded by: hsa:9058
is: E7ETH5
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_8c41bf69_f048_404f_8af2_153b7e9ec1ab
name: _H77542_1_r
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:H77542
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true

metaM 4izp c
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
is: SBO:0000247
is: CHEBI:57255
type: Species
initial amount: NaN
name: 4-Imidazolone-5-propanoate
is: HMDB01014
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaR PPItm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
product: MODEL1310110062#
is: SBO:0000185
name: diphopshate transporter, mitochondrial
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110062#_fc4837e3_15c9_420d_b938_719d635e702d
name: FECH
constant: false
is: P22830
is encoded by: hsa:2235
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaR ALAt2r
reversible: true
fast: false
reactant: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
name: L-alanine reversible transport via proton symport
kinetic law: MODEL1310110062#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD

metaM pe hs c
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
has only substance units: false
is: CHEBI:16038
name: phosphatidylethanolamine
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR S6T7g
reversible: false
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000176

metaR MG3er
is: SBO:0000176
reactant: MODEL1310110062#
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
type: Reaction
kinetic law: MODEL1310110062#
fast: false

metaM hdcoa c
boundary condition: false
type: Species
name: Hexadecenoyl-CoA (n-C16:1CoA)
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06532
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110062#_2e811fdb_6237_4525_ab24_3f9c9d8301b5
is: Q16348
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6565
has only substance units: false
name: SLC15A2
initial concentration: NaN

metaR FACOAL161
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000176
reversible: true
fast: false
name: fatty-acid--CoA ligase (hexadecenoate)
type: Reaction
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_b8b7b3fd_2e01_40da_b9f2_1fd5398f0b89
is encoded by: hsa:8776
name: MTMR1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q13613
boundary condition: true
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_3e919660_3efc_4211_bc3f_5bc79ade0ebd
is: SBO:0000297
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:509
has only substance units: false
has part: Q6I9V2
is encoded by: hsa:498
has part: P25705
type: Species
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_93ddf08c_a7ba_4275_91c2_b6d312e9fde7
type: Species
constant: false
is encoded by: hsa:84105
is: Q9H0N5
initial concentration: NaN
name: PCBD2
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_9dd9d20f_f504_4edb_b029_f6067849403f
has only substance units: false
name: AK1
type: Species
is encoded by: hsa:203
is: P00568
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaM ade e
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
boundary condition: false
is: CHEBI:16708
has only substance units: false
is: HMDB00034
initial concentration: 1.0
name: adenine
type: Species

metaM retinal c
name: retinal
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01358
is: CHEBI:15035
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_0c0b0a83_eae3_45d3_88bf_e43e3c36944f
is: E2QRH8
is encoded by: hsa:5332
name: PLCB4
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_5478e647_be2d_4d2d_91ee_ea4b352d4123
type: Species
name: _AI291895_1_c
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI291895

http://identifiers.org/biomodels.db/MODEL1310110062#_6fbc793d_fb4c_449d_a868_e7be8a4eb917
name: MDH2
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4191
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P40926

metaR r2384
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110062#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#

metaR MI1P Dtn
reactant: MODEL1310110062#
name: inositol 1-phosphate nuclear transport (diffusion)
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_3da088e3_ed37_474c_a7fc_348fbce2d244
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: ACSS2
initial concentration: NaN
is: Q5QPH3
is encoded by: hsa:55902
type: Species

metaM ncam e
boundary condition: false
is: C00153
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: Nicotinamide
is: HMDB01406
type: Species
is: SBO:0000247
notes: FORMULA: C6H6N2O CHARGE: 0
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110062#_feffea64_0584_4bb9_bfa6_6aa367408090
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q92569
boundary condition: true
has only substance units: false
name: PIK3R3
is encoded by: hsa:8503
is: SBO:0000252

metaR CYTK4
is: SBO:0000176
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reactant: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.3
name: cytidylate kinase (dCMP)(GTP)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_26f5c7ca_6c2a_4dca_8a96_bc6abaa1be3e
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: ETFA
has only substance units: false
is: P13804
is encoded by: hsa:2108
is: SBO:0000252
type: Species

metaR G12MT2 L
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: false
is: SBO:0000176
fast: false

metaR APOC LYS BTNP
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: false
product: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
type: Reaction
fast: false
name: proteolysis of apoC-Lys-btn
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR SADT
type: Reaction
kinetic law: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
is described by: ECO:0000269
reversible: false
name: sulfate adenylyltransferase
is: SBO:0000176
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.25

metaR MMMm
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is version of: http://identifiers.org/ec-code/5.4.99.2
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110062#
name: methylmalonyl-CoA mutase
fast: false
kinetic law: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#

metaM ocdcea l
has only substance units: false
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
boundary condition: false
initial concentration: 1.0
name: oleate
type: Species
constant: false
initial amount: NaN
is: CHEBI:30823
is: SBO:0000247

metaR ADRNCRNt
reactant: MODEL1310110062#
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
reversible: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110062#

metaM adpcoa x
is: SBO:0000247
constant: false
is: C14143
boundary condition: false
is: HMDB04047
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: adipoylcoa

metaR r0149
is: SBO:0000176
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.14.13.39
is described by: ECO:0000000
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110062#_2d4c27b4_6845_472b_9ce1_3ce84bb1e1aa
name: PIK3CA:PIK3R1
boundary condition: true
type: Species
is: SBO:0000297
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5295
has part: P27986
has only substance units: false

metaM undcoa m
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB13114
has only substance units: false
name: undecanoylcoa
notes: FORMULA: C32H52N7O17P3S CHARGE: -4

metaR r2385
modifier: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110062#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_1ddd7914_54a1_4255_8f33_3902901eb86b
has part: C9JPQ8
is encoded by: hsa:5095
initial concentration: NaN
name: PCCA:PCCB
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:5096
has part: P05166
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_43d25423_5ad8_4784_b6b0_8754bded1eb0
is encoded by: hsa:2589
initial amount: NaN
constant: false
is: Q10472
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: GALNT1

http://identifiers.org/biomodels.db/MODEL1310110062#_8385ebdc_177f_4b63_86c1_c50a312bdb48
constant: false
is encoded by: hsa:117247
type: Species
initial amount: NaN
is: Q8TF71
has only substance units: false
name: SLC16A10
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM lnlncgcoa r
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:57363
is: SBO:0000247
boundary condition: false
is: HMDB06368
constant: false

metaM cspg a e
is: SBO:0000247
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: CHEBI:16040
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
boundary condition: false
is: HMDB00630
initial concentration: 1.0
type: Species

metaR CYTK5
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (dCMP)

metaR CHSTEROLtrc
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
reversible: true
name: transport of cholesterol into the cytosol
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
type: Reaction
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_56cb3cb0_e3b6_4203_8e2b_77eb95601849
initial concentration: NaN
constant: false
name: ADSL
boundary condition: true
initial amount: NaN
is encoded by: hsa:158
type: Species
is: P30566
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_ed3502fc_eda2_4619_b36c_0deef1ad7071
type: Species
name: DPM3
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:54344
initial concentration: NaN
is: Q86TM7
is: SBO:0000252
constant: false

metaM ksi pre27 g
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 27
constant: false
initial concentration: 1.0
is: HMDB00175
has only substance units: false
is: C00130
initial amount: NaN
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: SBO:0000247
boundary condition: false
type: Species

metaM hpyr c
constant: false
type: Species
has only substance units: false
is: HMDB01352
is: CHEBI:17180
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 3-hydroxypyruvate
initial amount: NaN
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168

metaR 4HBZCOAFm
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000176
fast: false
name: 4-hydroxybenzoyl-CoA formation
reversible: false
kinetic law: MODEL1310110062#

metaR SERCYSNaEx
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reversible: false
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)

metaR r2386
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
modifier: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
type: Reaction
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110062#_4fb31c93_7ea9_477d_b5a1_93927e9cff94
is: O14975
initial concentration: NaN
constant: false
is encoded by: hsa:11001
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: SLC27A2

metaM ncam c
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Nicotinamide
is: C00153
type: Species
notes: FORMULA: C6H6N2O CHARGE: 0
initial amount: NaN
constant: false
is: HMDB01406
is: CHEBI:0
is: SBO:0000247

metaM 42A3HP24DB c
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB04083
has only substance units: false
is: http://identifiers.org/pubchem.compound/7956
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
boundary condition: false
constant: false
is: C05645
type: Species

metaR CYTK6
kinetic law: MODEL1310110062#
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110062#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_18af234a_d51a_4020_a668_c4d470ec6043
is encoded by: hsa:29920
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: Q96C36
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PYCR2

metaR LNLNCACPT1
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_f5956ecc_0c7f_4c07_98b3_00ee72af20b7
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:389015
has only substance units: false
type: Species
constant: false
name: SLC9A4
is: SBO:0000252
is: Q6AI14

metaR r2387
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
product: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110062#
fast: false

metaR PPItr
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
name: Diphosphate transporter, endoplasmic reticulum
reversible: true
fast: false
type: Reaction
product: MODEL1310110062#

metaR ARACHCRNt
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
reversible: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000185
modifier: MODEL1310110062#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000

metaR MI145PK
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.127
name: inositol-1,4,5-trisphosphate 3-kinase
type: Reaction
is described by: ECO:0000269
reversible: false

metaR GTHRDtr
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
name: glutathione transport via diffusion
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
reversible: true
is: SBO:0000185

metaR CYTK7
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110062#
reversible: true
product: MODEL1310110062#
fast: false
name: cytidylate kinase (CMP,UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

metaR DPCOAPPe
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Pyrophasphatase (dephospho-CoA, extracellular)
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110062#
is described by: ECO:0000134

metaR FAOXC164GC163m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR BILIRUBt2
name: bilirubin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110062#
is described by: ECO:0000269
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
reversible: true

metaR EX 3tdcrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaM 2oxoadp c
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
name: 2-oxoadipate(2-)
is: SBO:0000247
initial amount: NaN
is: HMDB00225
is: CHEBI:57499

metaM dgtp e
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
type: Species
is: CHEBI:16497
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01440

metaM cholcoa c
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01374
name: choloyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57373
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
constant: false
boundary condition: false

metaM clpn hs c
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
type: Species
constant: false
is: SBO:0000247
is: CHEBI:28494
initial concentration: 1.0
boundary condition: false
name: cardiolipin

metaR G14T8g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
fast: false

metaM CE5236 n
is: HMDB03952
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
is: CHEBI:28002
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR H2Otn
is: SBO:0000185
name: H2O transport, nuclear
reversible: true
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110062#
is described by: ECO:0000000

metaR EX tdcrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaM adpcoa c
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB04047
name: adipoylcoa
is: C14143
notes: FORMULA: C27H39N7O19P3S CHARGE: -5

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaR CHOLESTle
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110062#
name: hydrolysis of cholesterol ester by cholesterol esterase
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.1.13
is: SBO:0000176
reversible: false
fast: false
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110062#_5787adfe_f67a_4e92_bebf_fd4e5a54c376
is: SBO:0000297
type: Species
has part: P48201
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:518
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_56b7ad2d_e8da_449b_a3ba_978825303b50
is encoded by: hsa:AI539321
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: _AI539321_1_c
initial amount: NaN
type: Species
boundary condition: true

metaR r1803
reactant: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_e5769d6a_2753_47cb_b88a_7fcc1949c529
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:115019
name: SLC26A9
has only substance units: false
is: Q7LBE3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_841a9750_fdd9_40f7_aa7d_f2e7ed832c6d
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P26572
is encoded by: hsa:4245
constant: false
name: MGAT1
type: Species
is: SBO:0000252

metaM ksii core2 pre5 g
boundary condition: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00175
constant: false
name: keratan sulfate II biosynthesis, precursor 5
is: SBO:0000247
is: C00130
type: Species

metaM ala L c
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00161
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
name: L-alanine

metaR H2Otm
modifier: MODEL1310110062#
reversible: true
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185
name: H2O transport, mitochondrial
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
fast: false
is described by: ECO:0000269

metaR VALPHELAT2tc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_00d4e865_4e57_485d_8adf_3eef1a47b037
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5095
name: PCCA
boundary condition: true
is: SBO:0000252
is: C9JPQ8
initial concentration: NaN

metaR r1957
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110062#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000185

metaR C14STRr
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
fast: false
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
name: C-14 sterol reductase
modifier: MODEL1310110062#

metaM 2octdectecoa m
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB06294
type: Species
initial amount: NaN
name: 2,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110062#_c9d45522_5e06_45f6_9ad3_d9b67c60363f
has only substance units: false
constant: false
is encoded by: hsa:353
initial amount: NaN
type: Species
is: P07741
boundary condition: true
initial concentration: NaN
name: APRT
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_a9ec49b9_1107_4316_9868_06f902930bdf
name: GMPR2
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:51292
is: Q9P2T1
is: SBO:0000252

metaR AG13T3g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction
reversible: false
reactant: MODEL1310110062#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110062#

metaR NCAMUP
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
is: SBO:0000185
product: MODEL1310110062#
name: Nicotinamide acid uptake
reversible: false
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR CDIPTr
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.8.11
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
kinetic law: MODEL1310110062#
reversible: true
name: phosphatidylinositol synthase (Homo sapiens)

metaM dolmanp L r
is: SBO:0000247
is: CHEBI:15809
name: Dolichyl phosphate D-mannose, human liver homolog
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

metaR GTHPm
modifier: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
reactant: MODEL1310110062#
name: glutathione peroxidase, mitochondria
fast: false
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.11.1.12
type: Reaction

metaM hdcoa m
initial amount: NaN
is: HMDB06532
name: Hexadecenoyl-CoA (n-C16:1CoA)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_4c35b8d5_1af6_423c_b94d_7fce3f25e5e5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC26A7
type: Species
is: Q8TE54
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:115111

metaR PROt2r
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
name: L-proline reversible transport via proton symport
modifier: MODEL1310110062#
type: Reaction

metaM ksi pre5 g
notes: FORMULA: C101H164N7O75SX CHARGE: -2
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 5
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067

metaR H2Otp
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
name: H2O transport, peroxisomal
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000185

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_62c60815_8ec9_4c00_9ef9_de26d7f469ce
initial concentration: NaN
boundary condition: true
name: NME1
type: Species
is encoded by: hsa:4830
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR T4HCINNMFM
type: Reaction
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: false
name: 4-hydroxycinnamate formation
is: SBO:0000176

metaR ALAGLNexR
product: MODEL1310110062#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110062#
name: L-alanine/glutamine reversible exchange
reactant: MODEL1310110062#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#

metaR r1955
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110062#
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_3c1475e8_3c7e_4574_8540_fea89334ab49
name: RHBG
is encoded by: hsa:57127
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q9H310
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_1f49d8a8_d16d_4063_ab36_1aaa3541c746
is encoded by: hsa:1718
is: SBO:0000252
name: DHCR24
initial amount: NaN
initial concentration: NaN
type: Species
is: Q15392
boundary condition: true
has only substance units: false
constant: false

metaM 2mop m
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: HMDB01172
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57700
name: 2-methyl-3-oxopropanoate

metaR PPItx
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
name: Diphosphate transporter, peroxisome
fast: false
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaM m1mpdol L c
is: CHEBI:28067
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1

metaM ahcys r
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16680
name: S-adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_a11da2cc_b9ae_4582_b2b1_057b96fa4efd
boundary condition: true
initial amount: NaN
is encoded by: hsa:3073
name: HEXA
is: P06865
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR EX 3hexdcrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaR r0587
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is: SBO:0000176
product: MODEL1310110062#

metaR r1952
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110062#
product: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_927dea80_b403_4304_ab39_7466d67ffb35
is encoded by: hsa:FLJ44968
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: _FLJ44968_1_m
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_5e33809e_3a35_4f8f_9b58_1d99d0a713c2
type: Species
is encoded by: hsa:8897
name: MTMR3
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR MI145PP
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.86
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_de89bfb1_2dd8_4377_b152_a0d67725c63f
type: Species
is: SBO:0000252
is encoded by: hsa:3939
is: P00338
boundary condition: true
constant: false
has only substance units: false
name: LDHA
initial amount: NaN
initial concentration: NaN

metaM gsn c
name: Guanosine
type: Species
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00387
boundary condition: false
is: HMDB00133
constant: false
has only substance units: false
is: CHEBI:16750

metaM pail45p hs c
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910

metaM leuktrA4 e
is: HMDB01337
is: CHEBI:57463
name: leukotriene A4(1-)
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_128cc8f2_43d5_4ef7_9064_0959951187b2
is encoded by: hsa:314
constant: false
is: O75106
name: AOC2
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

metaR TCYNTt
type: Reaction
kinetic law: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is: SBO:0000185
product: MODEL1310110062#
is described by: ECO:0000000

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR CLS hs
is described by: ECO:0000000
product: MODEL1310110062#
type: Reaction
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
reactant: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
name: cardiolipin synthase (homo sapiens)

metaM cdpdag hs c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: CDP-diacylglycerol(2-)

http://identifiers.org/biomodels.db/MODEL1310110062#_080d1aa4_534e_44ad_8e65_a4c65e52d41f
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: RHAG
is: Q96E98
is encoded by: hsa:6005
initial concentration: NaN
constant: false
has only substance units: false

metaR MMTSADm
is: SBO:0000176
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
fast: false
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_92535361_cbe2_49c6_983b_99a3f2b6aee3
type: Species
is encoded by: hsa:686
name: BTD
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: P43251
boundary condition: true
initial amount: NaN

metaR HSD11B1r
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.146
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true
product: MODEL1310110062#
name: 11-beta-hydroxysteroid dehydrogenase type 1

metaR NDPK1m
reversible: true
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110062#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
product: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_61244a95_fc45_478b_b7b8_a19570aadc93
constant: false
initial concentration: NaN
name: DGKZ
type: Species
has only substance units: false
is encoded by: hsa:8525
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: B7Z2M9

http://identifiers.org/biomodels.db/MODEL1310110062#_ee79740c_ba64_4428_bbfa_fe4fa685796d
is: P50226
boundary condition: true
constant: false
name: SULT1A2
initial concentration: NaN
type: Species
is encoded by: hsa:6799
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM dgtp c
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
initial amount: NaN
is: SBO:0000247
is: CHEBI:16497
is: C00286
type: Species
name: dGTP
boundary condition: false
constant: false
initial concentration: 1.0

metaM c101coa c
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: HMDB04047
initial amount: NaN
boundary condition: false
constant: false
name: decenoylcoa
is: C14143
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM m5mpdol L r
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:37634
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_95881e94_79c6_4b57_bf12_0226a7346a81
is encoded by: hsa:1374
boundary condition: true
has only substance units: false
name: CPT1A
initial amount: NaN
initial concentration: NaN
is: Q8WZ48
is: SBO:0000252
constant: false
type: Species

metaR LGNCCOAtx
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: true
reactant: MODEL1310110062#
name: fatty acid intracellular transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_381eb9d2_1e86_4647_90df_1bb5422eaac5
boundary condition: true
is: SBO:0000252
name: NSDHL
is: Q15738
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:50814
constant: false

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR HIBDm
product: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.31
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
reactant: MODEL1310110062#
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaR NDPK1n
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
is: SBO:0000176
modifier: MODEL1310110062#
is described by: ECO:0000134
reversible: true

metaM fmn c
initial amount: NaN
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
has only substance units: false
type: Species
name: FMN
is: HMDB01520
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:58210
is: C00061

http://identifiers.org/biomodels.db/MODEL1310110062#_d59b7df1_e716_4de3_9acb_0d68d1cd6d03
type: Species
is encoded by: hsa:5288
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: O75747
name: PIK3C2G

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e87bf379_1700_4fc2_8dcf_496590424935
name: ACAA2
initial concentration: NaN
boundary condition: true
is: P42765
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10449
constant: false
initial amount: NaN

metaR LTC4Sr
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
name: Leukotriene C4 synthase
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.4.1.20

metaM leuktrA4 c
name: leukotriene A4(1-)
is: SBO:0000247
is: CHEBI:57463
is: HMDB01337
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR r1806
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110062#

metaM HC02205 c
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: prostaglandin-b2
is: SBO:0000247
is: CHEBI:28099
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_86e3c257_ff32_4f9a_9e7d_6840c12a092d
initial amount: NaN
is encoded by: hsa:122622
boundary condition: true
is: SBO:0000252
name: ADSSL1
has only substance units: false
initial concentration: NaN
type: Species
is: B3KTV4
constant: false

metaR ILETA
modifier: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
name: isoleucine transaminase
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#

metaM glutcoa c
is: HMDB01339
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
name: glutaryl-CoA(5-)
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
initial concentration: 1.0

metaM L2aadp m
name: L-2-aminoadipate(1-)
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB00510
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58672

metaR r1951
reversible: false
fast: false
modifier: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaR PA HStn
product: MODEL1310110062#
name: phosphatidate transport, nuclear
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

metaR DHDPBMTm
kinetic law: MODEL1310110062#
reversible: false
name: dihydroxydecaprenylbenzoate methyltransferase
product: MODEL1310110062#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
is version of: http://identifiers.org/ec-code/2.1.1.114

http://identifiers.org/biomodels.db/MODEL1310110062#_b117d125_ec61_4826_8bd5_ad4f932f6496
type: Species
is encoded by: hsa:3291
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P80365
initial concentration: NaN
name: HSD11B2
constant: false
has only substance units: false

metaM 2dr5p c
constant: false
initial concentration: 1.0
is: CHEBI:57651
initial amount: NaN
is: HMDB01031
name: 2-deoxy-D-ribose 5-phosphate(2-)
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
boundary condition: false

metaR DOPASFt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Dopamine 3-0-sulfate transport (diffusion)
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaM m2mn l
initial amount: NaN
constant: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: HMDB06537
boundary condition: false

metaR r0208
fast: false
reversible: true
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.4.1.1
is: SBO:0000176
modifier: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
kinetic law: MODEL1310110062#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
type: Reaction
reactant: MODEL1310110062#

metaR ADKd
is: SBO:0000176
modifier: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
name: adenylate kinase (d form)
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)

http://identifiers.org/biomodels.db/MODEL1310110062#_e860d922_3ebc_4e70_9e38_d925215ee962
type: Species
constant: false
name: MGST3
is: O14880
is encoded by: hsa:4259
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
is: CHEBI:61648
constant: false
name: VI2Fuc-nLc6
initial concentration: 1.0

metaM ahcys m
is: SBO:0000247
has only substance units: false
name: S-Adenosyl-L-homocysteine
is: CHEBI:16680
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
initial amount: NaN
is: C00021
type: Species
boundary condition: false
initial concentration: 1.0

metaM bilirub e
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
name: bilirubin(2-)
is: CHEBI:57977
constant: false
is: HMDB00054
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR CSNt
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000269
reactant: MODEL1310110062#
is: SBO:0000185
reversible: true
fast: false
name: cytosine transport via facilated diffusion

metaR LCADi D
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000304
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
kinetic law: MODEL1310110062#
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
product: MODEL1310110062#
reversible: false

metaM tethex3coa c
name: tetracosahexaenoyl coenzyme A
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205478
type: Species
is: HMDB06243
constant: false
is: C16168
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM HC02206 e
is: CHEBI:57399
type: Species
initial concentration: 1.0
name: prostaglandin C1(1-)
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686

http://identifiers.org/biomodels.db/MODEL1310110062#_82ed4d66_4313_40f6_9ca6_ac8c364d490e
is: A8K0S7
boundary condition: true
has only substance units: false
is encoded by: hsa:2542
is: SBO:0000252
name: SLC37A4
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM 2oxoadp m
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
boundary condition: false
name: 2-oxoadipate(2-)
initial concentration: 1.0
has only substance units: false
is: HMDB00225
constant: false
is: CHEBI:57499

metaR SFGTH
modifier: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.12
kinetic law: MODEL1310110062#
fast: false
name: S-Formylglutathione hydralase
reactant: MODEL1310110062#
is described by: ECO:0000269

metaM HC02205 e
is: CHEBI:28099
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: prostaglandin-b2

metaR O2St
is: SBO:0000185
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
name: superoxide anion transport via diffusion (extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#

metaM prostgi2 c
initial amount: NaN
boundary condition: false
type: Species
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
has only substance units: false
is: CHEBI:57403
is: HMDB01335
constant: false
initial concentration: 1.0

metaM akg c
is: C00026
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:16810
has only substance units: false
initial amount: NaN
name: 2-Oxoglutarate
is: HMDB00208
boundary condition: false

metaR LACLt
name: Lactate transport
reactant: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
is described by: ECO:0000134
type: Reaction
product: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_bb86d8e9_d871_476a_a25a_d7ac572f53b3
is: SBO:0000252
initial amount: NaN
name: SGPP1
constant: false
is: Q9BX95
has only substance units: false
is encoded by: hsa:81537
boundary condition: true
type: Species
initial concentration: NaN

metaR C226COAtx
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110062#
fast: false
is: SBO:0000185
name: fatty acid intracellular transport
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110062#

metaM HC00250 e
type: Species
name: hydrosulfide
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283

http://identifiers.org/biomodels.db/MODEL1310110062#_0f9e00da_92df_4748_9bb9_0a34f555029b
is: P30838
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: ALDH3A1
is encoded by: hsa:218
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c0dd03e8_2973_4fab_aa8d_370a28379adb
is encoded by: hsa:79646
is: SBO:0000252
initial amount: NaN
is: Q9H999
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: PANK3

metaR 4ABUTtcn
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110062#
reversible: false
name: transport of GABA
is: SBO:0000185
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
fast: false
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_4114f78d_f5f6_4e5e_8865_ea5d29b7b7c2
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:9060
is: O95340
initial concentration: NaN
is: SBO:0000252
constant: false
name: PAPSS2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_9bc019e3_3c27_4f65_bf96_f88e70e66a93
constant: false
is: Q02221
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1339
initial amount: NaN
name: COX6A2
boundary condition: true
has only substance units: false
type: Species

metaM bilirub c
name: bilirubin(2-)
is: SBO:0000247
is: CHEBI:57977
constant: false
is: HMDB00054
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaR GGH 7THFe
name: Gamma-glutamyl hydrolase (7THF), extracellular
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110062#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR MANtg
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110062#
name: mannose efflux from Golgi apparatus
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_493d7e52_22ac_4e18_8650_548cc9ff9801
has only substance units: false
initial concentration: NaN
type: Species
name: NDUFB11
constant: false
is encoded by: hsa:54539
is: SBO:0000252
boundary condition: true
is: Q9NX14
initial amount: NaN

metaR MMSAD3m
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
reversible: false
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.2.1.27
modifier: MODEL1310110062#

metaM HC02206 c
initial amount: NaN
is: CHEBI:57399
initial concentration: 1.0
name: prostaglandin C1(1-)
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false

metaM pail45p hs n
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:28910
constant: false
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_0e2c0596_2bd7_4c0c_af9b_933933a1c67d
is encoded by: hsa:100287639
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: _100287639_1_c
type: Species
initial amount: NaN

metaR r0584
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
product: MODEL1310110062#
is: SBO:0000176
type: Reaction
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reactant: MODEL1310110062#
reversible: true

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM c6crn c
is: HMDB00705
type: Species
constant: false
notes: FORMULA: C13H25NO4 CHARGE: 0
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: hexanoyl carnitine
boundary condition: false

metaR RE1533M
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110062#
fast: false
reversible: true
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
name: RE1533

metaR HOCDACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM gal l
has only substance units: false
initial amount: NaN
name: D-galactose
is: CHEBI:12936
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: HMDB00143
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false

metaM prostgi2 e
initial concentration: 1.0
constant: false
is: CHEBI:57403
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false
type: Species
boundary condition: false
is: HMDB01335
initial amount: NaN
is: SBO:0000247

metaR H2Otg
name: H2O transport, Golgi apparatus
fast: false
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_fc5dd606_c90f_4725_bf17_9d0b82d66b09
name: EGFL8
is encoded by: hsa:80864
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q99944
initial concentration: NaN
boundary condition: true
type: Species

metaR 3HKYNAKGAT
modifier: MODEL1310110062#
type: Reaction
is: SBO:0000176
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.64
is version of: http://identifiers.org/ec-code/2.6.1.7
is described by: ECO:0000304

metaR ABTti
is described by: ECO:0000000
product: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
name: L-arabinitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
type: Reaction

metaR ASNSERNaEx
type: Reaction
reversible: false
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_6233645f_6073_495b_8e02_62b405890372
has only substance units: false
boundary condition: true
is encoded by: hsa:3707
initial concentration: NaN
initial amount: NaN
is: P27987
name: ITPKB
constant: false
is: SBO:0000252
type: Species

metaM pail45p hs m
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
is: CHEBI:28910
type: Species

metaR r0434
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
fast: false
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110062#
is: SBO:0000176
reversible: true
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_ab2d3150_fc05_4e3b_a164_1fbdd1bcd408
constant: false
is: P15954
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1350
name: COX7C
initial amount: NaN

metaR PA HStg
reversible: true
reactant: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
name: phosphatidate scramblase
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
type: Reaction
is: SBO:0000185
fast: false

metaM gal e
has only substance units: false
is: CHEBI:0
name: D-Galactose
constant: false
is: C00124
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
type: Species

metaR C161CPT2
modifier: MODEL1310110062#
type: Reaction
reversible: false
kinetic law: MODEL1310110062#
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110062#
fast: false

metaM CE2011 e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: hypothiocyanite
constant: false
notes: FORMULA: CHNOS CHARGE: 0 INCHI: InChI=1/CHNOS/c2-1-4-3/h3H/p-1 EHMN_ABBREVIATION: CE2011
has only substance units: false
is: CHEBI:36781
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_galacglcgal14acglcgalgluside_hs_g
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
is: CHEBI:26174
boundary condition: false
name: i-antigen
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

metaR GALNTg
name: GalNAc transferase, Golgi apparatus
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.41
type: Reaction

metaM c6crn e
is: SBO:0000247
is: HMDB00705
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: hexanoyl carnitine
initial concentration: 1.0
notes: FORMULA: C13H25NO4 CHARGE: 0

metaM tetdece1crn e
is: HMDB02014
type: Species
notes: FORMULA: C21H39NO4 CHARGE: 0
name: tetradecenoyl carnitine
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_cadf90fc_43aa_4a56_9e22_0c88bb0e8c85
has only substance units: false
is: P47895
is encoded by: hsa:220
is: SBO:0000252
boundary condition: true
constant: false
name: ALDH1A3
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_5d07896f_3860_4bb6_8b34_4468051ceb9a
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:491
initial amount: NaN
is: Q4J699
initial concentration: NaN
name: ATP2B2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_546abed4_b555_4cce_a904_bb19d6805617
boundary condition: true
is: Q9NTN3
is encoded by: hsa:23169
name: SLC35D1
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_d5c49abd_252c_40af_a1c4_0227a4b71f37
initial amount: NaN
is: SBO:0000252
name: GART
is: P22102
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2618

http://identifiers.org/biomodels.db/MODEL1310110062#_263ccbc0_c6fd_48b8_8a8a_f8f6ca8c6d80
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7264
boundary condition: true
constant: false
has only substance units: false
is: Q13630
initial amount: NaN
type: Species
name: TSTA3

metaR B3GNT35g
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110062#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaM 3hdececrn c
initial amount: NaN
name: 3-hydroxyhexadecenoylcarnitine
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB02014
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C23H43NO5 CHARGE: 0

metaR r2497
kinetic law: MODEL1310110062#
fast: false
reversible: false
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#

metaR LEUtec
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
kinetic law: MODEL1310110062#
fast: false
name: L-leucine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110062#
is: SBO:0000185
modifier: MODEL1310110062#
product: MODEL1310110062#

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_35b28cec_e0f3_4256_964e_dea667abbae0
type: Species
is: Q3KQV9
name: UAP1L1
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:91373
has only substance units: false
is: SBO:0000252

metaR APOCFm
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Apocarboxylase formation, mitochondrial
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_a6e137d0_91fe_41f1_9fe3_dc37a041890b
is: P05166
name: PCCB
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5096
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_9a999459_d466_49a3_bb61_f396c7505ec5
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6470
has only substance units: false
name: SHMT1
type: Species

metaM tetdece1crn c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H39NO4 CHARGE: 0
initial amount: NaN
name: tetradecenoyl carnitine
has only substance units: false
constant: false
type: Species
is: HMDB02014
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_3d807b8a_a3a2_4809_b5d7_70f2d24412b1
constant: false
is: Q9NUB1
is encoded by: hsa:84532
is: SBO:0000252
name: ACSS1
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaR DNDPt10m
name: dADP transport via dCDP antiport
fast: false
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_7d3f06d8_eaa1_4490_a795_c57bf1d5857d
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is: P06744
is encoded by: hsa:2821
initial concentration: NaN
name: GPI
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_b069c8a1_fbe4_4e8b_b589_9fa2a7b370b0
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:4645
is: SBO:0000252
is: Q9H6Y6
has only substance units: false
name: MYO5B
initial concentration: NaN

metaR r0580
is version of: http://identifiers.org/ec-code/1.3.99.7
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is: SBO:0000176
reactant: MODEL1310110062#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
reversible: true
fast: false
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000

metaM 3hdececrn e
notes: FORMULA: C23H43NO5 CHARGE: 0
name: 3-hydroxyhexadecenoylcarnitine
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB13325
initial amount: NaN
is: SBO:0000247

metaM noncoa m
name: nonanoylcoa
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C01942
type: Species
constant: false
is: HMDB13028
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false

metaR 2AMADPTm
type: Reaction
modifier: MODEL1310110062#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
is described by: ECO:0000269
reversible: true
is: SBO:0000185
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877

metaM akg e
name: 2-oxoglutarate(2-)
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16810
boundary condition: false
constant: false
is: HMDB00208

metaR C161CPT1
is: SBO:0000176
product: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
kinetic law: MODEL1310110062#
name: production of palmitoleoylcarnitine
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_4be22053_87e7_41c7_bce6_2acfaea31a30
constant: false
initial concentration: NaN
name: DLST
is: P36957
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1743
initial amount: NaN
has only substance units: false
type: Species

metaM hdca e
is: HMDB00220
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1
constant: false
has only substance units: false
name: Hexadecanoate (n-C16:0)
is: C00249
boundary condition: false
type: Species
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110062#_fa077518_f7e3_46e1_96ed_559a612e433c
boundary condition: true
is: SBO:0000252
is encoded by: hsa:84076
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: Q9H0I9
constant: false
name: TKTL2

metaM leuleu e
name: Leucylleucine
notes: FORMULA: C12H24N2O3 CHARGE: 0
initial amount: NaN
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
constant: false
has only substance units: false
is: HMDB00660
is: C00095
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: CHEBI:15824
type: Species
initial amount: NaN

metaR FAOXC205C185m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_e8f2e104_4397_46e2_a0c8_46ed86e42da9
initial concentration: NaN
is: P49619
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: DGKG
boundary condition: true
has only substance units: false
is encoded by: hsa:1608

metaM g1m8mpdol L r
type: Species
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
is: SBO:0000247
is: C05870

metaM pro D e
boundary condition: false
is: HMDB03411
is: SBO:0000247
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:16313
has only substance units: false
name: D-proline

http://identifiers.org/biomodels.db/MODEL1310110062#_d2411200_0894_47f5_a5d2_2935f67ed183
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:210
constant: false
is: SBO:0000252
is: P13716
has only substance units: false
type: Species
boundary condition: true
name: ALAD

metaM 3octdece1coa c
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
is: HMDB13336
name: 3-hydroxyoctadecenoylcoa
boundary condition: false
initial concentration: 1.0
constant: false

metaR r0986
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
name: Vesicular transport
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000185

metaM mthgxl c
has only substance units: false
is: CHEBI:17158
type: Species
constant: false
name: methylglyoxal
is: HMDB01167
is: SBO:0000247
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r2394
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110062#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b0e00426_1eea_4166_9254_fdfec1940e3c
initial concentration: NaN
is encoded by: hsa:9517
constant: false
type: Species
is: O15270
is: SBO:0000252
has only substance units: false
name: SPTLC2
boundary condition: true
initial amount: NaN

metaR RE3524R
name: RE3524
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaM gal c
initial concentration: 1.0
is: C00124
boundary condition: false
is: CHEBI:0
type: Species
is: HMDB00143
name: D-Galactose
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0
initial amount: NaN
is: SBO:0000247

metaM apoC Lys c
name: Apocarboxylase (Lys residue)
notes: FORMULA: C6H13N2OX CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:32551
initial concentration: 1.0
is: HMDB00182
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_2c3f04bc_55f9_4851_9486_623bfe8359ff
initial concentration: NaN
is: Q59HH3
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: GART
is: SBO:0000252
is encoded by: hsa:2618
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_36c8333a_a64c_44cc_a448_3b3bbc2ec96f
initial amount: NaN
is encoded by: hsa:5337
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: PLD1
is: SBO:0000252
is: Q59EA4
constant: false

metaR r0002
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
name: Active transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:

metaR r0987
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110062#
name: Vesicular transport
fast: false

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR r0226
is described by: ECO:0000000
product: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
kinetic law: MODEL1310110062#
is: SBO:0000176
fast: false

metaM ksii core4 pre2 g
name: keratan sulfate II boisynthesis, precursor 2
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00175
constant: false
is: CHEBI:58053
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00130
notes: FORMULA: C47H76N4O33X CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110062#_4634ca32_b51c_4bc9_861c_6c55655fdea4
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:513
constant: false
boundary condition: true
is: SBO:0000252
name: ATP5D

http://identifiers.org/biomodels.db/MODEL1310110062#_58810637_0351_42e2_a465_868f5ac97f45
constant: false
is: SBO:0000297
name: ATP1B4:ATP1A2
has part: Q9UN42
is encoded by: hsa:477
initial amount: NaN
has part: P50993
is encoded by: hsa:23439
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_9e999c23_6405_484b_afab_8ba4c91a7dea
initial concentration: NaN
is: P19801
is encoded by: hsa:26
initial amount: NaN
is: SBO:0000252
name: ABP1
boundary condition: true
has only substance units: false
type: Species
constant: false

metaM leuleu c
name: Leucylleucine
notes: FORMULA: C12H24N2O3 CHARGE: 0
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/94244
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

metaM pro D c
boundary condition: false
is: HMDB03411
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16313
name: D-proline

metaM pchol hs c
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine
has only substance units: false
is: CHEBI:16110
type: Species
initial concentration: 1.0

metaR FTHFLm
notes: GENE_ASSOCIATION: (25902.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.4.3 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.3
fast: false
name: formate-tetrahydrofolate ligase, mitochondrial
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_b7b56744_961b_4477_818a_ab0a6daba385
is: SBO:0000252
is encoded by: hsa:217
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: ALDH2
boundary condition: true
is: P05091

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: HMDB00174
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: CHEBI:18287
type: Species
constant: false
boundary condition: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR r0437
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
reversible: true

metaR FAOXC2442246x
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000269
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#

metaR NAt5
product: MODEL1310110062#
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6548.1) or (6550.1) or (6549.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:8199403,PMID:8595899 NOTES:NCD
type: Reaction
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
name: sodium/ammonium proton antiporter
kinetic law: MODEL1310110062#

metaM dectricoa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
name: 2,4,7-decatrienoylcoa
boundary condition: false

metaM sarcs e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
initial concentration: 1.0
type: Species
name: sarcosine
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15611
constant: false
is: HMDB00271
is: SBO:0000247

metaM L2aadp c
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
type: Species
is: HMDB00510
name: L-2-aminoadipate(1-)
is: CHEBI:58672

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_ed8f6a78_5686_41f5_a80f_01b24a087930
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3157
name: HMGCS1
is: Q01581
has only substance units: false
type: Species

metaM naglc2p L c
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
is: CHEBI:18278
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
boundary condition: false
initial concentration: 1.0
constant: false

metaM dlnlcgcoa m
name: dihomo-gamma-linolenyl coenzyme A
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:27979
initial concentration: 1.0
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species

metaR DM pnto R
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for (R)-Pantothenate
type: Reaction

metaR r0377
modifier: MODEL1310110062#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
reactant: MODEL1310110062#
fast: false

metaM tchola c
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
has only substance units: false
name: taurocholic acid
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:36257
is: HMDB00036
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_90d02f2e_9223_4b37_a37a_13a173009511
constant: false
is: A8K596
initial concentration: NaN
name: SARDH
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:1757

metaM aps c
boundary condition: false
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
has only substance units: false
name: 5'-adenylyl sulfate(2-)
is: HMDB01003
is: CHEBI:58243
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_49d9fdaf_f3e8_44c2_bec0_13a6f0ea93a8
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P61457
is encoded by: hsa:5092
name: PCBD1
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_c80ce1aa_9b61_494b_8e8d_4393b1064c96
is encoded by: hsa:5728
is: F6KD01
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: PTEN
initial amount: NaN
initial concentration: NaN

metaM gal14acglcgalgluside hs g
name: Lactoneotetraosylceramide
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
has only substance units: false
is: CHEBI:17103
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaM 3dodtricoa m
initial concentration: 1.0
is: SBO:0000247
is: HMDB03952
boundary condition: false
has only substance units: false
is: C05280
name: 3,6,9-dodecatrienoylcoa
constant: false
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial amount: NaN

metaR ACOAD10m
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is described by: ECO:0000269
modifier: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial

metaM pchol hs e
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: CHEBI:16110
name: Phosphatidylcholine
constant: false

metaR NTD7
reversible: false
type: Reaction
name: 5'-nucleotidase (AMP)
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
is: SBO:0000176

metaR C8CRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR 10FTHFtm
reversible: true
reactant: MODEL1310110062#
type: Reaction
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110062#
fast: false
is described by: ECO:0000000
product: MODEL1310110062#
is: SBO:0000185

metaR SERGLNexR
name: L-Serine/Glutamine reversible exchange
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
reactant: MODEL1310110062#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110062#
kinetic law: MODEL1310110062#

metaR THBPT4ACAMDASE
reversible: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
kinetic law: MODEL1310110062#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395

metaR r1301
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Vesicular transport
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
type: Reaction
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_442da6a3_e640_47e6_9475_d7bdc32acfae
initial amount: NaN
is encoded by: hsa:6487
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: ST3GAL3

metaR CLPNDt
is described by: ECO:0000000
reversible: true
fast: false
name: fatty acid transport via diffusion
is: SBO:0000185
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM C02528 r
is: SBO:0000247
constant: false
is: CHEBI:36234
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
name: chenodeoxycholate
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00518

metaM acglcgalgbside hs g
is: CHEBI:26174
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: GlcNAc-Gal globoside
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_d060c866_d02a_4958_b62f_38111e2cca10
type: Species
is: P31213
name: SRD5A2
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6716
has only substance units: false
initial concentration: NaN

metaR ADK1
is described by: ECO:0000269
is: SBO:0000176
fast: false
kinetic law: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase

metaR NRPPHRtu
modifier: MODEL1310110062#
name: Norepinephrine uniport
reactant: MODEL1310110062#
is described by: ECO:0000269
kinetic law: MODEL1310110062#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
reversible: true
product: MODEL1310110062#

metaM uri e
has only substance units: false
is: CHEBI:16704
is: C00299
type: Species
initial amount: NaN
is: SBO:0000247
name: Uridine
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
initial concentration: 1.0
boundary condition: false

metaM amet c
constant: false
type: Species
is: CHEBI:15414
initial amount: NaN
name: S-Adenosyl-L-methionine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C00019
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185

metaR TSTSTERONEtr
reversible: true
type: Reaction
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: testosterone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185

metaR DOLDPP Ler
reactant: MODEL1310110062#
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
reversible: false
modifier: MODEL1310110062#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.43
type: Reaction

metaM chol c
is: CHEBI:15354
is: C00114
constant: false
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
name: Choline
is: HMDB00097
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR LPS
reversible: false
reactant: MODEL1310110062#
name: lipase
type: Reaction
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.34
is: SBO:0000176
modifier: MODEL1310110062#
is described by: ECO:0000000
kinetic law: MODEL1310110062#
product: MODEL1310110062#

metaM tchola e
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: taurocholic acid
boundary condition: false
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0
is: HMDB00036

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00174
constant: false
is: SBO:0000247
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: CHEBI:18287

metaM pchol hs g
type: Species
boundary condition: false
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16110

http://identifiers.org/biomodels.db/MODEL1310110062#_4f8522d5_d868_4d70_845c_d574a7006e4c
initial concentration: NaN
name: NME4
initial amount: NaN
type: Species
is: O00746
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:4833
constant: false

metaR C162OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_88718dac_c179_40c3_9719_ac82990dceee
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: TAZ
has only substance units: false
is: Q16635
is encoded by: hsa:6901
type: Species

metaR SPHK21c
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
name: sphingosine kinase 2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.91
reversible: false
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
fast: false

metaM hdca c
constant: false
name: palmitate
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial amount: NaN
is: CHEBI:7896
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00220

metaR EICOSTETt
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR 3HBCOAHLm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
product: MODEL1310110062#
reversible: false
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

metaM sql r
initial concentration: 1.0
is: CHEBI:15440
is: HMDB00256
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
name: squalene
boundary condition: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751

metaM 56dura c
name: 5,6-dihydrouracil
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: HMDB00076
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:15901
initial concentration: 1.0
has only substance units: false

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_73cd093a_1d4d_430f_8ff8_c5e231570738
initial amount: NaN
name: SLC4A5
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:57835
is: Q9BY07
has only substance units: false
boundary condition: true
constant: false

metaM dhcrm hs c
is: SBO:0000247
name: dihydroceramide
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
is: CHEBI:31488
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_fa006109_f073_4e2a_b4df_f6036de96d4c
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:10965
is: SBO:0000252
has only substance units: false
name: ACOT2
boundary condition: true
is: P49753
initial amount: NaN

metaR NTD6
type: Reaction
modifier: MODEL1310110062#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dAMP)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM cdp n
boundary condition: false
has only substance units: false
name: CDP(3-)
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
constant: false
is: HMDB01546

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM ksii core2 pre8 g
name: keratan sulfate II biosynthesis, precursor 8
is: HMDB00175
initial amount: NaN
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: CHEBI:58053
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00130
type: Species

metaM 3deccrn c
constant: false
is: HMDB13325
notes: FORMULA: C17H33NO5 CHARGE: 0
boundary condition: false
has only substance units: false
type: Species
name: 3-hydroxydecanoylcarnitine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR PDX5PO
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
reversible: true
fast: false
name: pyridoxine 5'-phosphate oxidase
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_5ea0d391_4980_4a22_a08c_d791da93976b
type: Species
initial concentration: NaN
name: CYP51A1
is encoded by: hsa:1595
has only substance units: false
is: SBO:0000252
is: Q16850
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_96fcb9a1_ee26_43fd_b24f_76e889a0d528
is: P15848
is: SBO:0000252
is encoded by: hsa:411
has only substance units: false
name: ARSB
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaM cholcoa x
boundary condition: false
type: Species
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
has only substance units: false
name: choloyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57373
constant: false

metaM HC00250 c
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
boundary condition: false
name: hydrosulfide
is: CHEBI:29919
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

metaR CORE3GTg
fast: false
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
modifier: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_115f88a0_555a_49af_937e_f1e46cc0f6cb
initial amount: NaN
name: DGKB
is encoded by: hsa:1607
has only substance units: false
is: Q9Y6T7
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species

metaR HEXDIACTD
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaR r1302
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Vesicular transport

metaR C162OHe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaM ksi deg36 l
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
name: keratan sulfate I, degradation product 36
is: HMDB00143
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaM chol e
is: SBO:0000247
is: CHEBI:15354
name: Choline
boundary condition: false
initial amount: NaN
is: HMDB00097
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114

http://identifiers.org/biomodels.db/MODEL1310110062#_ac7e4e46_e277_43da_a60a_64f7c2add0c7
initial concentration: NaN
initial amount: NaN
is: Q9UHI5
is: SBO:0000252
name: SLC7A8
boundary condition: true
constant: false
is encoded by: hsa:23428
has only substance units: false
type: Species

metaR NACHEX3ly
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
fast: false
product: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#

metaR HDECAACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

metaR PI34P4Pn
reactant: MODEL1310110062#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
is described by: ECO:0000000
name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase, nuclear
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction

metaM arachdcoa c
type: Species
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
boundary condition: false
initial amount: NaN
is: HMDB06523
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaR r1971
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
fast: false
type: Reaction
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_aa75ea40_bbbb_4cfb_89b9_e447ad135126
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC9A3
is encoded by: hsa:6550
constant: false
initial amount: NaN
boundary condition: true
is: P48764

metaR r0009
fast: false
reactant: MODEL1310110062#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is: SBO:0000176
product: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
is described by: ECO:0000000
kinetic law: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1

metaM hpdca c
initial concentration: 1.0
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB02259
is: CHEBI:32366
type: Species
name: margarate
constant: false
initial amount: NaN

metaM ksi deg39 l
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 39
notes: FORMULA: C48H81N3O36 CHARGE: 0
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species

metaM gam e
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: CHEBI:17315
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: D-Glucosamine
is: C00329
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01514

metaR GLUtr
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
kinetic law: MODEL1310110062#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110062#
type: Reaction
name: intracellular transport
is: SBO:0000185

metaM C02528 e
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:36234
boundary condition: false
type: Species
name: chenodeoxycholate

http://identifiers.org/biomodels.db/MODEL1310110062#_5872c00b_17d4_46b4_b417_44bbeeb728d7
is: SBO:0000252
is: P16885
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5336
name: PLCG2
initial amount: NaN

metaR FAOXC15C13m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaM mi34p c
is: HMDB06235
type: Species
is: CHEBI:28858
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 1D-myo-Inositol 3,4-bisphosphate

metaR RE1520M
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
modifier: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1520
kinetic law: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM 3deccrn e
type: Species
notes: FORMULA: C17H33NO5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00791
constant: false
is: SBO:0000247
is: C02838
name: 3-hydroxydecanoylcarnitine
has only substance units: false

metaR r1970
fast: false
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction

metaR EX c12dc
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecanedioyl carnitine
type: Reaction

metaM dlnlcgcoa c
type: Species
is: CHEBI:27979
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: dihomo-gamma-linolenyl coenzyme A

metaM ksi deg32 l
boundary condition: false
is: HMDB00143
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 32
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12936
has only substance units: false
type: Species

metaR r0156
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
type: Reaction
is described by: ECO:0000000

metaM aacoa c
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0
is: C00332
is: HMDB01484
is: CHEBI:57286
is: SBO:0000247
initial amount: NaN
name: Acetoacetyl-CoA
type: Species
boundary condition: false
has only substance units: false
constant: false

metaM dgtp n
is: SBO:0000247
initial amount: NaN
name: dGTP
boundary condition: false
type: Species
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
constant: false
is: HMDB01440
is: C00286
has only substance units: false

metaM hpdca e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
boundary condition: false
is: HMDB02259
has only substance units: false
constant: false
is: CHEBI:32366
type: Species
name: margarate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_3e105bdf_5920_4072_934a_ee6b103ea7be
name: NDUFB2
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:4708
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: H7C5B8

metaR ACGALK
type: Reaction
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: N-acetylgalactosamine kinase
reversible: false
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is: SBO:0000176

metaM acnam n
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:35418
boundary condition: false
name: N-acetylneuraminate

http://identifiers.org/biomodels.db/MODEL1310110062#_cf454f34_cdf9_4725_88c3_fca6d55e8a05
initial amount: NaN
is: SBO:0000252
is: P00374
constant: false
boundary condition: true
is encoded by: hsa:1719
type: Species
initial concentration: NaN
name: DHFR
has only substance units: false

metaM gam c
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
boundary condition: false
is: HMDB01514
is: CHEBI:17315
initial concentration: 1.0
name: D-Glucosamine
has only substance units: false
initial amount: NaN
type: Species
is: C00329
is: SBO:0000247
constant: false

metaR CYSGLUexR
product: MODEL1310110062#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110062#
is described by: ECO:0000304
name: L-cysteine/L-glutamine reversible exchanger

metaM leuktrA4 r
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57463
name: leukotriene A4(1-)
has only substance units: false
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337

metaM uri c
initial amount: NaN
name: Uridine
has only substance units: false
is: SBO:0000247
is: HMDB00296
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
boundary condition: false
type: Species
initial concentration: 1.0
is: C00299
constant: false
is: CHEBI:16704

http://identifiers.org/biomodels.db/MODEL1310110062#_3610092c_ed8e_430a_aa82_0fbd18afc8e1
boundary condition: true
initial concentration: NaN
type: Species
name: _AV727634_1_c
initial amount: NaN
is encoded by: hsa:AV727634
has only substance units: false
constant: false
is: SBO:0000252

metaR RE2972M
name: RE2972
type: Reaction
product: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.67
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:

metaM q10h2 m
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
type: Species
is: HMDB13111
constant: false
has only substance units: false

metaR r0157
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.2
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
fast: false
reactant: MODEL1310110062#
reversible: false
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_cd5fc29f_a406_435f_91fb_d257cd6edc5d
constant: false
has only substance units: false
is encoded by: hsa:221823
is: SBO:0000252
initial concentration: NaN
name: PRPS1L1
type: Species
boundary condition: true
initial amount: NaN

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaR ADK3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
reactant: MODEL1310110062#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110062#
product: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
name: adentylate kinase (GTP)
type: Reaction

metaM acnam l
is: CHEBI:35418
is: HMDB00230
constant: false
boundary condition: false
name: N-acetylneuraminate
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_feb1665e_14eb_407b_aba6_6acf6ad7121e
is: P54819
is: SBO:0000252
name: AK2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:204
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaM pmtcrn x
type: Species
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00222
is: SBO:0000247
is: CHEBI:17490
name: L-palmitoylcarnitine
boundary condition: false

metaR LNSTLSr
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.4.99.7
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
name: lanosterol synthase
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
product: MODEL1310110062#
reversible: false

metaR GCALDD
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110062#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Glycolaldehyde dehydrogenase
is described by: ECO:0000304
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR

metaM CE2838 e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
type: Species
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: C01936
has only substance units: false
name: maltononaose

metaM 3octdece1coa m
initial concentration: 1.0
type: Species
has only substance units: false
name: 3-hydroxyoctadecenoylcoa
is: SBO:0000247
boundary condition: false
is: HMDB06294
initial amount: NaN
constant: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4

metaM cys L c
is: HMDB00574
boundary condition: false
is: CHEBI:17561
name: L-cysteine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR GLYt7 211 r
is described by: ECO:0000269
product: MODEL1310110062#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

metaM sarcs c
constant: false
boundary condition: false
is: C00213
initial amount: NaN
name: Sarcosine
is: CHEBI:3513
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0
is: SBO:0000247
has only substance units: false
is: HMDB00271

metaR r2041
fast: false
modifier: MODEL1310110062#
reversible: false
reactant: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#

metaR CSEPASEly
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
reversible: false
product: MODEL1310110062#

metaM ppa c
type: Species
initial amount: NaN
is: HMDB00237
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
is: SBO:0000247
name: propionate
is: CHEBI:17272
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_325bb170_14d9_4dc5_b856_72001f3fd8c8
has only substance units: false
initial amount: NaN
name: INPP4A
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3631
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_bdaf4181_a5c4_4f46_9260_d5239993fb94
initial amount: NaN
name: AMY1A
initial concentration: NaN
is: Q6NSB3
is: SBO:0000252
is encoded by: hsa:276
constant: false
boundary condition: true
type: Species
has only substance units: false

metaR NACHEXA18ly
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaM 7thf e
is: SBO:0000247
type: Species
constant: false
name: heptaglutamyl folate (THF)
is: HMDB06559
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
initial amount: NaN

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_fbe31122_eaca_4a50_9b49_5e85b615a1c1
initial amount: NaN
is: SBO:0000252
name: CYP27A1
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:1593
is: Q02318
type: Species
boundary condition: true

metaR THP2Ctp
is described by: ECO:0000000
reversible: true
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
fast: false
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is: SBO:0000185
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_094822ff_c78d_404f_89c4_fdcd357ee5dd
name: PRDX2
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:7001
is: P32119

metaM ksii core4 pre1 g
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 1
is: CHEBI:28067
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C36H60N3O25X CHARGE: 0

metaM 3dpdhb me m
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
initial amount: NaN
is: CHEBI:50776
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate

metaM cys L e
is: CHEBI:17561
boundary condition: false
is: SBO:0000247
name: L-cysteine
initial concentration: 1.0
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
type: Species
constant: false
is: HMDB00574
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c4426b2e_d4ff_4ff7_84fd_38f44255991b
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q96QE2
initial amount: NaN
is encoded by: hsa:114134
constant: false
name: SLC2A13
has only substance units: false
type: Species

metaR r2043
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000185

metaR PROD2m
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is version of: http://identifiers.org/ec-code/1.5.99.8
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: Proline dehydrogenase (m)
modifier: MODEL1310110062#
is described by: ECO:0000254
product: MODEL1310110062#
reversible: false

metaR GLYCTDle
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: difussion of glycerol accross the brush border membrane
is: SBO:0000185
reactant: MODEL1310110062#
fast: false
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000134
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_1919ab76_1cc7_4f93_b99c_a225cb0dce65
constant: false
has only substance units: false
boundary condition: true
is: P49327
type: Species
initial amount: NaN
is encoded by: hsa:2194
name: FASN
initial concentration: NaN
is: SBO:0000252

metaM glutcoa m
initial amount: NaN
name: glutaryl-CoA(5-)
constant: false
type: Species
is: HMDB01339
has only substance units: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: CHEBI:57378
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR PPAm
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
fast: false
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.6.1.1
type: Reaction
reactant: MODEL1310110062#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
name: inorganic diphosphatase
modifier: MODEL1310110062#

metaR GALASE10ly
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reversible: false
product: MODEL1310110062#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110062#

metaM nad c
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57540
type: Species
name: Nicotinamide adenine dinucleotide
is: HMDB00902
is: C00003
boundary condition: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305

metaM bilirub r
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
name: bilirubin(2-)
is: CHEBI:57977
is: SBO:0000247
initial concentration: 1.0
is: HMDB00054
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaR FAOXC14C14OHm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaM amet m
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
is: HMDB01185
is: CHEBI:15414
initial amount: NaN
name: S-Adenosyl-L-methionine
boundary condition: false
is: C00019

metaR DUMPtn
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false

metaR S6T6g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_f9836692_45f4_4169_8f1d_3a0b12f79a3a
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:27034
type: Species
initial concentration: NaN
name: ACAD8
is: Q6ZWP6

metaR MECOAS1m
kinetic law: MODEL1310110062#
is described by: ECO:0000304
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110062#
fast: false
type: Reaction
name: mesaconate--CoA ligase (GDP-forming)
reactant: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is: SBO:0000176

metaM ksii core2 pre3 g
is: SBO:0000247
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 3
is: HMDB00175
is: C00130
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN

metaR ALADGLNexR
name: L-alanine/glutamine reversible exchange
type: Reaction
is: SBO:0000185
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110062#
reversible: true
is described by: ECO:0000304
product: MODEL1310110062#

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
reactant: MODEL1310110062#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110062#_aa7e66f5_c597_4a35_84f3_197b3512ec0b
is: Q9UHI7
name: SLC23A1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:9963
type: Species
initial amount: NaN
boundary condition: true

metaR MACACI
fast: false
is described by: ECO:0000269
name: maleylacetoacetate isomerase
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD

metaR FAOXC141C141OHm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaM arg L c
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00517
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: CHEBI:32682
name: L-argininium(1+)
has only substance units: false

metaR GLCt4
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
name: glucose transport via sodium symport
is described by: ECO:0000269
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true
fast: false
reactant: MODEL1310110062#
is: SBO:0000185

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM HC02207 c
name: prostaglandin-c2
type: Species
is: CHEBI:27555
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR AG13T2g
is: SBO:0000176
fast: false
product: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
kinetic law: MODEL1310110062#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_6844a0d5_72e9_46c9_9d2c_0dc0ee9d78f8
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM chol n
is: HMDB00097
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:15354
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: choline
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_12c8b74b_8a81_4c2d_8686_fa3b3f0b167e
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6534
is: Q99884
name: SLC6A7
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_20f65163_437b_4570_88f8_da0b1fb6cb23
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:2629
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: GBA

metaR EX no2 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nitrite exchange
type: Reaction

metaM lnlncgcoa m
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
type: Species
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
is: CHEBI:57363

metaR r1967
modifier: MODEL1310110062#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110062#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GLYSARCNc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaM 2maacoa m
has only substance units: false
is: SBO:0000247
is: HMDB01157
name: 2-methylacetoacetyl-CoA(4-)
initial concentration: 1.0
constant: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species
is: CHEBI:57335
initial amount: NaN
boundary condition: false

metaM pail4p hs n
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaR LTC4CP
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
name: Leukotriene C4 carboxypeptidase

metaM aacoa m
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
constant: false
is: CHEBI:57286
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: acetoacetyl-CoA(4-)
type: Species

metaR PHEACGLNt
is: SBO:0000185
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
name: PHEACGLN extracellular transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
type: Reaction
is described by: ECO:0000000
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_07bfd4d7_0605_40ea_965d_884ac029c0d2
initial concentration: NaN
type: Species
is encoded by: hsa:2109
name: ETFA:ETFB
boundary condition: true
constant: false
is: SBO:0000297
has part: P38117
has only substance units: false
initial amount: NaN

metaM ppa e
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate
initial amount: NaN
has only substance units: false
is: CHEBI:17272

metaM nad n
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57540
name: NAD(1-)
is: HMDB00902
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_dce21b76_669d_4ed8_ba3f_96188b2745f3
constant: false
type: Species
is: SBO:0000252
name: ADCY5
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:111
is: O95622

metaM spc hs c
name: sphingosylphosphorylcholine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: http://identifiers.org/pubchem.compound/5311445
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false

metaM arg L e
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00517
boundary condition: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
has only substance units: false
is: SBO:0000247

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM HC02207 e
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false
type: Species
name: prostaglandin-c2
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR NACHEX9ly
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
modifier: MODEL1310110062#

metaM q10h2 c
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
name: Ubiquinol-10
is: HMDB13111
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_6f6259d7_f426_4bb9_89f9_de2dae6dd9c7
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8897
has only substance units: false
initial amount: NaN
name: MTMR3

http://identifiers.org/biomodels.db/MODEL1310110062#_8b39f574_716b_4412_85c9_c9d2f2a50751
is: SBO:0000252
constant: false
name: NDUFA3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4696
boundary condition: true
is: O95167
type: Species
has only substance units: false

metaM tethex3 e
is: SBO:0000247
name: tetracosahexaenoic acid, n-3
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB02007
boundary condition: false
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-

metaM HC01522 c
is: SBO:0000247
name: Gentisate aldehyde
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
constant: false
is: CHEBI:28508
boundary condition: false

metaM fdp c
constant: false
name: D-Fructose 1,6-bisphosphate
boundary condition: false
is: HMDB01058
is: SBO:0000247
is: C00354
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: http://identifiers.org/pubchem.compound/3647
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:16905

metaM acac m
is: HMDB00060
constant: false
initial concentration: 1.0
is: CHEBI:13705
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: acetoacetate
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR S6TASE9ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
reversible: true
name: N-acetylgalactosamine-6-sulfatase, lysosomal
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110062#
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110062#
is: SBO:0000176

metaM tetpent6coa x
is: C16172
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: tetracosapentaenoyl coenzyme A, n-6

metaR NNATr
name: nicotinate-nucleotide adenylyltransferase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (349565.1) or (23057.2) or (23057.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:12574164,PMID:14516279 NOTES:JLR
modifier: MODEL1310110062#
reversible: true
is: SBO:0000176
product: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#

metaM spc hs e
boundary condition: false
is: http://identifiers.org/pubchem.compound/5311445
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
name: sphingosylphosphorylcholine
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaM hdca r
is: HMDB00220
is: C00249
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
type: Species
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:7896
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_202fa229_94cf_493f_a0f3_652f76757fe5
initial concentration: NaN
is encoded by: hsa:3706
name: ITPKA
is: SBO:0000252
constant: false
initial amount: NaN
is: P23677
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_4b85db76_d182_45f8_bb96_e0dda4cd4080
type: Species
is: SBO:0000297
constant: false
initial amount: NaN
is encoded by: hsa:51227
has only substance units: false
initial concentration: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true

metaR DNDPt33m
reactant: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
name: dGDP transport via dUDP antiport
fast: false
is: SBO:0000185

metaM q10h2 e
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false
type: Species
initial amount: NaN
is: HMDB13111
constant: false
name: Ubiquinol-10
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_90763508_a8fe_4e97_bd59_ab67007f6b98
is encoded by: hsa:4513
has part: P00414
is encoded by: hsa:84701
has part: Q6YFQ2
is encoded by: hsa:170712
is encoded by: hsa:1345
has part: Q6FGA0
has part: Q7GXZ8
is encoded by: hsa:1351
constant: false
is encoded by: hsa:1327
has part: Q53XN1
has part: Q7GXY8
is encoded by: hsa:341947
is encoded by: hsa:1339
is encoded by: hsa:1337
initial amount: NaN
has part: Q8TF08
is encoded by: hsa:1349
is encoded by: hsa:4514
is encoded by: hsa:4512
has part: P24311
has part: H0UI06
has part: Q02221
is encoded by: hsa:1346
is encoded by: hsa:1340
initial concentration: NaN
has part: P20674
has part: P15954
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P14854
is encoded by: hsa:1329
has part: P12074
is: SBO:0000297
has part: Q96KJ9
is encoded by: hsa:1347
is encoded by: hsa:9167
boundary condition: true
has part: Q53YB7
has only substance units: false
has part: P13073
is encoded by: hsa:9377
has part: P24310
has part: P09669
is encoded by: hsa:125965
has part: Q7Z4L0
is encoded by: hsa:1350
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_74749833_6b12_494b_9460_90568f9c90cf
name: _AI640625_1_c
is: SBO:0000252
is encoded by: hsa:AI640625
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR FACOAL170
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
reactant: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110062#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
type: Reaction
name: fatty-acid--CoA ligase

metaM tethex3 c
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
is: HMDB02007
name: tetracosahexaenoic acid, n-3
initial concentration: 1.0
has only substance units: false

metaM nad m
is: C00003
is: CHEBI:57540
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_54003f27_5f06_407e_9d42_ba2929c6c763
constant: false
is encoded by: hsa:9791
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P48651
boundary condition: true
name: PTDSS1

http://identifiers.org/biomodels.db/MODEL1310110062#_366502c9_e50c_4390_b940_750c6175ae1e
boundary condition: true
is: SBO:0000252
name: ACAT2
initial amount: NaN
constant: false
type: Species
is: Q9BWD1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:39

http://identifiers.org/biomodels.db/MODEL1310110062#_5c9d563d_7b22_4641_86fc_be867b07b519
has only substance units: false
name: _PRO1933_1_m
initial amount: NaN
is encoded by: hsa:PRO1933
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaR FAOXC122m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_bea6f268_840e_4d34_a4af_5073db37286e
is encoded by: hsa:63917
name: GALNT11
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: B3KWF4
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_72e63d70_172e_4a50_9b23_48c293cf793a
initial concentration: NaN
type: Species
is encoded by: hsa:55350
is: SBO:0000297
initial amount: NaN
name: VNN3:VNN2:VNN1
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b1f1b1dd_73b5_4086_839c_16bccebe8cc5
is encoded by: hsa:55350
name: VNN3:VNN2:VNN1
is encoded by: hsa:8875
initial concentration: NaN
boundary condition: true
is: SBO:0000297
has part: O95498
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b8292f7a_b0c3_464d_8c97_8313a3f2f901
is: SBO:0000252
type: Species
has only substance units: false
is: Q6IBC0
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:3155
name: HMGCL
initial amount: NaN

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_d426d145_2a74_4f62_9838_25731fe8ce02
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PIGX
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:54965
is: Q8TBF5

http://identifiers.org/biomodels.db/MODEL1310110062#_9401b36d_e308_4f28_92db_47070c81b2db
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51022
is: SBO:0000252
name: GLRX2
has only substance units: false

metaM CE0785 m
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
name: cis,cis-myristo-5,8-dienoyl-CoA
boundary condition: false
is: CHEBI:57795
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_967d8c22_a991_4f08_9f47_eb45ee82fa4b
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: COQ6
is encoded by: hsa:51004
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is: B7Z3K8

metaR THRGLYexR
modifier: MODEL1310110062#
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110062#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000304
product: MODEL1310110062#
fast: false
reversible: true

metaR GRTTx
is version of: http://identifiers.org/ec-code/2.5.1.1
modifier: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110062#
type: Reaction
name: geranyltranstransferase
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110062#
reversible: false
fast: false
product: MODEL1310110062#

metaM C02528 c
is: HMDB00518
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
is: CHEBI:36234
name: chenodeoxycholate

metaM ksi deg17 l
is: CHEBI:12936
constant: false
is: SBO:0000247
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 17
is: HMDB00143
type: Species
boundary condition: false

metaM 2ddecdicoa m
name: 2,6-dodecadienoylcoa
is: HMDB11123
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: C05279
type: Species
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_c397c8a8_6c42_43ae_8cca_f4c2949942e8
initial amount: NaN
is: SBO:0000252
name: _AI697028_1_m
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AI697028

http://identifiers.org/biomodels.db/MODEL1310110062#_034f9eb9_6459_4165_a8b7_a695bd7405f0
is: SBO:0000252
name: COX8C
constant: false
initial concentration: NaN
is encoded by: hsa:341947
has only substance units: false
boundary condition: true
is: Q7Z4L0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_bc29401a_091e_4b7e_b57b_a6c1bc0242a8
type: Species
is: P31040
is encoded by: hsa:6389
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SDHA

metaR GALASE1ly
product: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
modifier: MODEL1310110062#

metaM chol g
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
name: choline
is: HMDB00097
is: SBO:0000247
is: CHEBI:15354
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaR DM dsT antigen g
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaM xylt c
is: HMDB02917
initial amount: NaN
type: Species
boundary condition: false
name: xylitol
constant: false
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM tetpent6 c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06322
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: SBO:0000247
has only substance units: false
name: tetracosapentaenoic acid, n-6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_460be487_a4fc_47da_95fc_63df7be75334
is: SBO:0000252
boundary condition: true
is encoded by: hsa:52
initial concentration: NaN
is: Q59EH3
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: ACP1

metaM HC02208 e
name: prostaglandin-d1
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:27696
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_a4ecaed0_c5c2_4e2c_a10e_1180c71276f6
boundary condition: true
initial concentration: NaN
constant: false
has part: P56134
has only substance units: false
is encoded by: hsa:522
initial amount: NaN
is encoded by: hsa:9551
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297

metaM cs a l
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: HMDB02183
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
boundary condition: false
is: CHEBI:36005

metaR C12DCTD
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaR TDCRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_fbbb4ef7_aaf9_4887_94ae_6f15fe174c78
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5313
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: PKLR
boundary condition: true
is: P30613

metaM cdp c
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
is: CHEBI:58069
type: Species
boundary condition: false
constant: false
is: HMDB01546
initial amount: NaN
has only substance units: false
is: C00112
name: CDP
is: SBO:0000247

metaR r0990
kinetic law: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
fast: false
is described by: ECO:0000000

metaR RPEc
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000134
name: ribulose 5-phosphate 3-epimerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reversible: true
type: Reaction

metaR r0596
fast: false
product: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
is described by: ECO:0000000
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reversible: false

metaR HIStN1
is described by: ECO:0000269
product: MODEL1310110062#
modifier: MODEL1310110062#
name: Histidine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_96970e7a_b8ed_43fe_b345_369cdc0400dd
name: PLCXD2
initial amount: NaN
is: Q0VAA5
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:257068
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_37c5a990_56a6_4c70_9a80_a339781cf8ca
initial concentration: NaN
name: PIGA
constant: false
is: SBO:0000252
is encoded by: hsa:5277
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaR DTTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
reversible: true
fast: false
name: dTTP diffusion in nucleus
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_64b20f3c_8783_4040_be7c_3ea71256cb8c
is encoded by: hsa:8836
initial concentration: NaN
is: SBO:0000252
is: Q92820
initial amount: NaN
boundary condition: true
name: GGH
type: Species
has only substance units: false
constant: false

metaR FAOXC260240x
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
kinetic law: MODEL1310110062#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#
modifier: MODEL1310110062#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110062#

metaR GLUDym
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
modifier: MODEL1310110062#
reactant: MODEL1310110062#
name: glutamate dehydrogenase (NADP), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110062#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.1.3
product: MODEL1310110062#
is described by: ECO:0000269
fast: false

metaR r0993
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
reactant: MODEL1310110062#
product: MODEL1310110062#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM xylt e
type: Species
has only substance units: false
boundary condition: false
constant: false
name: xylitol
is: CHEBI:17151
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: HMDB02917
initial amount: NaN
initial concentration: 1.0

metaM HC02180 e
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: CHEBI:28728
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: thromboxane-b2
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR ALAASNNaEx
product: MODEL1310110062#
type: Reaction
is: SBO:0000185
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)

metaR DNDPt24m
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
name: dTDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110062#

metaM tetpent6 e
boundary condition: false
is: HMDB06322
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
has only substance units: false
name: tetracosapentaenoic acid, n-6
constant: false
initial amount: NaN

metaM 3hmp m
name: 3-hydroxy-2-methylpropanoate
boundary condition: false
constant: false
type: Species
is: HMDB00023
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: CHEBI:11805
is: SBO:0000247

metaR RE2799C
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is: SBO:0000176
type: Reaction
name: RE2799
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_b996679f_f20e_4e8f_be0b_1785c01339ee
initial concentration: NaN
is: P11182
name: DBT
is encoded by: hsa:1629
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaR C4STMO2Pr
reversible: false
name: C-4 methyl sterol oxidase
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.170
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is: SBO:0000176
kinetic law: MODEL1310110062#

metaM ptth c
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
type: Species
boundary condition: false
is: CHEBI:16753
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB03426
initial concentration: 1.0
name: pantetheine

metaR r0594
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reversible: true
product: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_af86214d_ffa4_402b_a1d7_ef9172a58d9a
initial concentration: NaN
is encoded by: hsa:79071
has only substance units: false
is: Q9H5J4
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: ELOVL6
type: Species

metaM s2l2n2m2masn e
is: C00255
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: HMDB00244
has only substance units: false
is: CHEBI:3554
boundary condition: false
name: de-Fuc form of PA6

http://identifiers.org/biomodels.db/MODEL1310110062#_dc0eb80b_3a48_48c7_9682_36d7fccc5f64
initial concentration: NaN
constant: false
is: SBO:0000252
is: P26439
has only substance units: false
is encoded by: hsa:3284
name: HSD3B2
boundary condition: true
initial amount: NaN
type: Species

metaR DM ethamp r
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR SPMDOX
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: beta-Alanine metabolism EC Number: 1.5.99.6 Confidence Level: 2 AUTHORS: PMID:10657958 NOTES:SAB
name: Spermidine:(acceptor) oxidoreductase
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_570a7295_d73e_412d_aac8_c433a40e2e13
initial concentration: NaN
constant: false
is: SBO:0000252
is: O00754
initial amount: NaN
is encoded by: hsa:4125
type: Species
has only substance units: false
boundary condition: true
name: MAN2B1

metaM nad x
initial amount: NaN
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide
is: C00003
is: CHEBI:57540
is: HMDB00902
boundary condition: false
type: Species
is: SBO:0000247

metaR GLCAASE9ly
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110062#
name: beta-glucuronidase, lysosomal

metaM CE5854 e
is: CHEBI:24757
name: gama-CEHC-glucuronide
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
type: Species
initial amount: NaN

metaM eicostet e
boundary condition: false
name: eicosatetranoic acid
is: CHEBI:36033
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1
initial concentration: 1.0
has only substance units: false
is: HMDB02177
type: Species

metaM HC02180 c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
type: Species
is: SBO:0000247
name: thromboxane-b2
is: CHEBI:28728
has only substance units: false
initial amount: NaN

metaM 2dp6mobq m
initial amount: NaN
constant: false
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
is: SBO:0000247
has only substance units: false
is: CHEBI:50773

metaM s2l2n2m2masn l
type: Species
name: de-Fuc form of PA6
is: HMDB00174
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:18287
notes: FORMULA: C84H135N6O61X CHARGE: -2
initial amount: NaN
constant: false
is: SBO:0000247

metaM core4 g
type: Species
is: SBO:0000247
has only substance units: false
name: Core 4
is: CHEBI:16478
notes: FORMULA: C24H40N3O15X CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaM lnlnca c
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388
boundary condition: false
is: SBO:0000247
name: alpha-linolenate
is: CHEBI:32387
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaM ksi deg21 l
constant: false
has only substance units: false
is: HMDB00143
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
name: keratan sulfate I, degradation product 21
is: CHEBI:12936
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_f85de475_bfde_4c68_8d90_dd4524426b85
is: SBO:0000252
is encoded by: hsa:36
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: ACADSB
boundary condition: true
is: P45954
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_a03b1c2a_a5a3_43f6_9877_0178eb33d226
type: Species
is encoded by: hsa:506
boundary condition: true
initial amount: NaN
name: ATP5B
constant: false
initial concentration: NaN
has only substance units: false
is: P06576
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_ee3d7fc9_4c5f_42e0_8fb3_3afa570a6924
type: Species
is encoded by: hsa:AL050025
name: _AL050025_1_c
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_c1b564a9_b450_409e_9bc4_f6587c4a9637
is: P56381
initial concentration: NaN
is encoded by: hsa:514
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: ATP5E

metaM clpndcoa x
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06267
name: clupanodonyl CoA
is: http://identifiers.org/pubchem.compound/47205476
type: Species
has only substance units: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
boundary condition: false
is: C16166

metaR PSSA1 hs
fast: false
modifier: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.8.29
is described by: ECO:0000269
reversible: true
name: Phosphatidylserine synthase homo sapiens
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is: SBO:0000176

metaR MGSA2
product: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
name: methyglyoxylate synthase 2 (from g3p)
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_e3c1ded3_f703_470a_b3a6_e90812dbc371
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: E7ET30
name: AK3
is encoded by: hsa:50808
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_4631cf3d_341a_415c_81b5_7750e66f8b8e
is encoded by: hsa:19
is: SBO:0000252
initial amount: NaN
name: ABCA1
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: O95477

http://identifiers.org/biomodels.db/MODEL1310110062#_be3042ee_80c0_4717_813f_177d11f1bf09
is: SBO:0000252
is: P52790
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: HK3
is encoded by: hsa:3101
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9a6e288f_02f4_4dd8_835a_36f27e82e3a4
is: B3KQH0
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55343
boundary condition: true
name: SLC35C1

http://identifiers.org/biomodels.db/MODEL1310110062#_2b66e8c2_9fab_4d06_8178_5b3970614920
is: P19971
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1890
constant: false
name: TYMP
boundary condition: true

metaM T antigen g
has only substance units: false
initial amount: NaN
name: T antigen (core 1)
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C14H24NO10X CHARGE: 0
is: CHEBI:22783
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_7c54a38f_e2d1_43c8_8def_3251ff384324
is: SBO:0000252
constant: false
initial concentration: NaN
name: PC
initial amount: NaN
is encoded by: hsa:5091
type: Species
has only substance units: false
boundary condition: true

metaM acnam c
type: Species
is: HMDB00230
boundary condition: false
has only substance units: false
name: N-acetylneuraminate
is: SBO:0000247
constant: false
is: CHEBI:35418
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0

metaR FAOXTC101TC102m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_65b69e37_7c7f_4cf6_bf2f_1d072a60df32
initial concentration: NaN
is encoded by: hsa:55808
has only substance units: false
is: Q9NSC7
name: ST6GALNAC1
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252

metaR LNLCt
name: Linoleic acid (n-C18:2) transport in via diffusion
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
fast: false
product: MODEL1310110062#
is described by: ECO:0000000

metaR B3GNT34g
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_cbca2797_0d42_4bc6_b10b_fa095de8e5d6
constant: false
is encoded by: hsa:3939
name: LDHA:LDHB
has only substance units: false
initial amount: NaN
initial concentration: NaN
has part: P00338
boundary condition: true
type: Species
is: SBO:0000297

metaM fe3 e
type: Species
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: HMDB12943
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:29034
name: Fe3+
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_5586ae8a_0365_4842_82f1_34185c5b191d
constant: false
name: PYCR1
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P32322
initial amount: NaN
type: Species
is encoded by: hsa:5831
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_6958a941_826a_44f4_9627_664be45241db
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6817
type: Species
name: SULT1A1
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaM eicostet c
type: Species
boundary condition: false
is: CHEBI:36033
notes: FORMULA: C20H31O2 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: HMDB02177
name: eicosatetranoic acid

metaR HIVCACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaM bamppald c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01106
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: http://identifiers.org/pubchem.compound/7975
type: Species
initial amount: NaN
constant: false
name: beta-Aminopropion aldehyde
has only substance units: false
is: C05665

metaM ksi pre6 g
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00175
initial concentration: 1.0
is: C00130
name: keratan sulfate I biosynthesis, precursor 6
notes: FORMULA: C107H174N7O80SX CHARGE: -2
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:58053

metaM lnlnca e
is: HMDB01388
name: alpha-linolenate
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
initial concentration: 1.0
is: CHEBI:32387

metaM CE0693 m
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
name: 3-oxolaur-6-cis-enoyl-CoA
constant: false
is: CHEBI:28387
boundary condition: false
is: HMDB11123
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM nad r
is: HMDB00902
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57540
initial amount: NaN
name: NAD(1-)
constant: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: SBO:0000247
type: Species

metaM hdca l
type: Species
is: HMDB00220
name: palmitate
has only substance units: false
boundary condition: false
is: CHEBI:7896
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_7d5b9586_ff4d_4a2e_afa6_c51afc12a4b9
is encoded by: hsa:3283
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: HSD3B1
type: Species
initial amount: NaN
is: P14060

http://identifiers.org/biomodels.db/MODEL1310110062#_dbe703d4_1406_440d_893f_3ee4bfb90a22
is: Q9NUB1
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ACSS1
is encoded by: hsa:84532

metaM HC01602 c
constant: false
type: Species
is: C00234
is: CHEBI:57454
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-Formyltetrahydrofolate

metaR r0591
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
reversible: true
modifier: MODEL1310110062#
product: MODEL1310110062#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9

metaR NaKt
name: Na+/K+ exchanging ATPase
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.6.3.9
modifier: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
reversible: false
kinetic law: MODEL1310110062#
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_74557298_f457_4b64_920d_52ec5f7e73ec
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:6519
has only substance units: false
is: Q07837
boundary condition: true
is: SBO:0000252
name: SLC3A1

metaM cdp e
is: CHEBI:58069
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
is: HMDB01546
initial amount: NaN
initial concentration: 1.0
name: CDP(3-)
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_40e07c16_ba17_48b7_8af2_4c4fb1b5dac9
boundary condition: true
is: Q99798
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: ACO2
initial concentration: NaN
is encoded by: hsa:50
has only substance units: false

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR RE1532M
is: SBO:0000176
is described by: ECO:0000000
name: RE1532
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_63330ad7_e165_421a_b6c9_e0c2b2fe475c
is encoded by: hsa:9167
boundary condition: true
has only substance units: false
name: COX7A2L
is: Q6FGA0
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM lnlncgcoa c
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
is: SBO:0000247
constant: false
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
type: Species
is: HMDB06368
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_42649397_677e_44d7_9e9c_0dc126cb78bf
is: O75438
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4707
has only substance units: false
name: NDUFB1
is: SBO:0000252
initial amount: NaN
constant: false

metaR FAOXC121C101m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_a041e633_71ea_480c_8ebe_a952f5ce8f41
name: GALNT10
initial amount: NaN
type: Species
is: Q86SR1
constant: false
is: SBO:0000252
is encoded by: hsa:55568
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM aacoa x
initial amount: NaN
is: HMDB01484
is: CHEBI:57286
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
constant: false
name: acetoacetyl-CoA(4-)

metaR DM T antigen g
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR SR5ARr
reactant: MODEL1310110062#
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
is version of: http://identifiers.org/ec-code/1.3.99.5
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate

metaR FUCASE2ly
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110062#
type: Reaction
name: alpha-fucosidase, lysosomal
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
fast: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110062#

metaR r0590
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
reversible: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_789de12a_d4de_43dc_9490_26f1ef2751ff
has only substance units: false
is encoded by: hsa:2687
constant: false
type: Species
is: P36269
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: GGT5

metaM fe3 c
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: Fe CHARGE: 3
name: Fe3+
is: SBO:0000247
is: HMDB12943

metaR EX ivcrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_34de235f_36ef_414b_84a2_49b3a8720a7a
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:219
constant: false
has only substance units: false
is: P30837
name: ALDH1B1

metaM 5mta e
notes: FORMULA: C11H15N5O3S CHARGE: 0
boundary condition: false
has only substance units: false
name: 5-Methylthioadenosine
initial concentration: 1.0
is: HMDB01173
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: C00170
is: CHEBI:17509

metaR r1606
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true

metaR EX c51crn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_c1b9b9e0_a6ea_44df_97e8_78ca73481863
is: Q9P019
is encoded by: hsa:29085
initial amount: NaN
boundary condition: true
name: PHPT1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_dc4e76bf_b86f_43f0_a851_85a386f65326
type: Species
constant: false
is encoded by: hsa:229
boundary condition: true
is: P05062
initial concentration: NaN
name: ALDOB
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR B MANNASEly
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
fast: false
kinetic law: MODEL1310110062#
name: beta-mannosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.25
reversible: false
is: SBO:0000176
product: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_fc9204f4_4f6f_4d90_833d_69af4423d4b5
name: PRODH
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is: O43272
is encoded by: hsa:5625
initial concentration: NaN
has only substance units: false

metaR RE0830C
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110062#
fast: false
name: RE0830
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_d7f40738_b40b_4aab_983d_8f74ae80933b
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:AA526438
constant: false
name: _AA526438_1_c
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: CHEBI:26174
has only substance units: false
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
boundary condition: false
constant: false
type: Species

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR r1605
fast: false
reversible: true
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_d8fe16da_f599_46be_832a_f5a05d887f27
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: SLC5A10
constant: false
is: SBO:0000252
is: A0PJK1
is encoded by: hsa:125206
has only substance units: false

metaM ser L e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00187
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
type: Species
name: L-serine

metaM pmtcrn c
boundary condition: false
name: L-palmitoylcarnitine
is: CHEBI:17490
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_3d54849d_05d7_4e8f_838e_1d1a8b31c9af
is: SBO:0000252
name: ATP1B1
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:481
initial concentration: NaN
constant: false
is: A3KLL5

metaM HC02208 c
is: CHEBI:27696
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
boundary condition: false
type: Species
constant: false

metaM lgnccoa c
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB06526
has only substance units: false
constant: false
name: lignocericyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1

metaM nadh x
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01487

metaR TAURtcx
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
modifier: MODEL1310110062#
is described by: ECO:0000212
reactant: MODEL1310110062#
fast: false
product: MODEL1310110062#
reversible: true
type: Reaction
is: SBO:0000185
name: taurine transport (sodium symport) (cytosol to peroxisome)

http://identifiers.org/biomodels.db/MODEL1310110062#_fe2167c5_beaa_45f4_ba89_556f0adc1a3b
constant: false
is: SBO:0000252
is encoded by: hsa:AA278423
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: _AA278423_1_m
initial concentration: NaN

metaR ADK1m
modifier: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: adenylate kinase, mitochondrial
fast: false

metaM 5mta c
has only substance units: false
boundary condition: false
name: 5-Methylthioadenosine
initial concentration: 1.0
is: HMDB01173
type: Species
is: C00170
is: CHEBI:17509
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170

metaM 3hexdcoa c
type: Species
initial amount: NaN
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
boundary condition: false
name: 3-hydroxyhexadecanoylcoa
constant: false
initial concentration: 1.0
is: HMDB03932
is: C05258

metaR r1604
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_cb56123f_473a_43e0_a7a3_1adfa8e966ce
initial concentration: NaN
name: TPI1P2
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:286016
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_275bb8bb_08ee_48b7_ac4e_f2b8c9481ecc
name: PIP4K2A
boundary condition: true
is encoded by: hsa:5305
is: P48426
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR C141OHe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaM hdcecrn m
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
name: Hexadecenoyl carnitine
is: HMDB00222
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110062#_07c4af7b_e17c_45be_ae66_736da18cd72c
is encoded by: hsa:7296
has only substance units: false
is: SBO:0000252
name: TXNRD1
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaR GALGALGALTHCRMte
product: MODEL1310110062#
reversible: true
name: galgalgalthcrm hs transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000185
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

http://identifiers.org/biomodels.db/MODEL1310110062#_a54cd799_2bcd_425d_a3ef_a2f6d541fe9f
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: HCST
is: Q9UBK5
initial concentration: NaN
is encoded by: hsa:10870
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_f429367a_8491_4552_9bb6_4eb4766efbd4
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI601100
constant: false
has only substance units: false
name: _AI601100_1_m

metaR CYSGLNNaEx
reactant: MODEL1310110062#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
modifier: MODEL1310110062#
reversible: false

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR r1603
reversible: true
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_ba1adf06_d6d0_44ce_80ca_d3e1e23b1b48
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: GALNT8
initial concentration: NaN
is encoded by: hsa:26290
type: Species
initial amount: NaN
is: Q9NY28

metaR DOPAt4 2 r
name: Dopamine reversible transport in via sodium symport (1:2)
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
is: SBO:0000185
modifier: MODEL1310110062#
type: Reaction
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110062#_71630501_4b61_461e_bbd4_c75b9959d9ca
is encoded by: hsa:1718
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: DHCR24
is: SBO:0000252
is: Q15392
constant: false
type: Species
boundary condition: true

metaR URIK1
name: uridine kinase (ATP:Uridine)
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.48
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
reversible: false
reactant: MODEL1310110062#
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#

metaR C141OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM 3ttetddcoa c
initial concentration: 1.0
constant: false
has only substance units: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB02014

http://identifiers.org/biomodels.db/MODEL1310110062#_af33c520_4645_408b_a114_e104e7a6abc1
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9NY65
is encoded by: hsa:1962
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: EHHADH

metaM g6p r
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
type: Species
is: CHEBI:61548
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01401
is: C00092
has only substance units: false

metaR r0340
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000176
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110062#
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reversible: false
modifier: MODEL1310110062#
type: Reaction

metaR TETTET6t
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110062#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR LDH L
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110062#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#
name: L-lactate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D

metaR r1602
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110062#

metaR CYSALANaEx
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110062#
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
is: SBO:0000185
modifier: MODEL1310110062#

metaR TKT2
name: transketolase
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
reactant: MODEL1310110062#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.1
modifier: MODEL1310110062#
reversible: true

metaM 3ddcrn e
notes: FORMULA: C19H37NO5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: 3-hydroxydodecanoylcarnitine
is: SBO:0000247
is: HMDB00791
boundary condition: false
is: C02838

metaR r2059
type: Reaction
reactant: MODEL1310110062#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110062#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR TIGCRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaR r0129
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reversible: true
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110062#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110062#

metaM mescoa m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27969
constant: false
is: C06028
is: SBO:0000247
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
type: Species
has only substance units: false
name: Mesaconyl-CoA
boundary condition: false

metaM ksii core4 pre4 g
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00175
is: C00130
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 4
has only substance units: false
notes: FORMULA: C61H99N5O43X CHARGE: -1

metaR r0236
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
kinetic law: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reactant: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction

metaM 3hdcoa m
has only substance units: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
name: (S)-3-Hydroxydecanoyl-CoA
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247

metaR TKT1
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.1
name: transketolase
kinetic law: MODEL1310110062#
is: SBO:0000176
fast: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110062#_58760ee4_7582_4bbf_99ff_ed1323cd7fff
type: Species
initial amount: NaN
has part: Q07326
initial concentration: NaN
has part: Q8TEQ8
constant: false
is encoded by: hsa:84720
is: SBO:0000297
has only substance units: false
boundary condition: true
is encoded by: hsa:5281
name: PIGF:PIGO

metaR r1600
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110062#_4b5f51e8_7235_4ee9_8cbe_0f64c6415738
has only substance units: false
is encoded by: hsa:1606
name: DGKA
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P23743

metaM tdcrn e
notes: FORMULA: C21H41NO4 CHARGE: 0
initial concentration: 1.0
constant: false
boundary condition: false
name: myristoyl carnitine
is: SBO:0000247
is: HMDB05066
has only substance units: false
type: Species
initial amount: NaN

metaM HC01115 c
has only substance units: false
name: NeuNGc
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: CHEBI:29025
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_5d0922bc_16ef_4956_8339_446e45a8dce5
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:522
constant: false
type: Species
name: ATP5J
is: P18859
has only substance units: false
initial concentration: NaN

metaM 3ddcrn c
notes: FORMULA: C19H37NO5 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: 3-hydroxydodecanoylcarnitine
type: Species
constant: false
boundary condition: false
is: HMDB00623
is: SBO:0000247

metaR GDPFUCtg
modifier: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
name: GDPFuc Golgi transport via CMP antiport
type: Reaction
reactant: MODEL1310110062#
reversible: true
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
is described by: ECO:0000269
fast: false

metaM ksii core2 pre7 g
notes: FORMULA: C67H108N5O51SX CHARGE: -2
initial amount: NaN
is: CHEBI:58053
is: C00130
boundary condition: false
is: HMDB00175
constant: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 7
initial concentration: 1.0
type: Species

metaR MAN6PI
name: mannose-6-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.8
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000304
kinetic law: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_00a539d0_4a94_43e4_a8f7_2ecc785ba0ef
initial concentration: NaN
name: RPIA
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:22934
is: P49247
type: Species
is: SBO:0000252
constant: false

metaR KAS8
is described by: ECO:0000269
modifier: MODEL1310110062#
reversible: false
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
is: SBO:0000176
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR CYTK11n
kinetic law: MODEL1310110062#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dGTP),nuclear
reactant: MODEL1310110062#
is: SBO:0000176
type: Reaction
product: MODEL1310110062#
reversible: true

metaR AHEXASE2ly
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
reversible: false
modifier: MODEL1310110062#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is described by: ECO:0000000

metaR r0127
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
type: Reaction
modifier: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
product: MODEL1310110062#

metaM 3htdcoa m
constant: false
has only substance units: false
type: Species
is: SBO:0000247
name: (S)-3-Hydroxytetradecanoyl-CoA
is: HMDB02288
initial amount: NaN
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0

metaM ser L c
constant: false
is: HMDB00187
is: CHEBI:17115
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: L-serine

metaR KSII CORE2t
name: keratan sulfate II (core2) transport, golgi to extracellular
kinetic law: MODEL1310110062#
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_3501133f_15e5_4228_a14a_38c1b898d73b
initial amount: NaN
initial concentration: NaN
name: ACSL6
is encoded by: hsa:23305
is: B2RB13
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_b81433cd_b71d_477c_9ed2_f851de42a041
initial amount: NaN
initial concentration: NaN
is: B3KT19
is encoded by: hsa:5295
is: SBO:0000252
constant: false
name: PIK3R1
boundary condition: true
type: Species
has only substance units: false

metaR SIAASE3ly
product: MODEL1310110062#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
is: SBO:0000176

metaR PPA
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000176
reversible: false
reactant: MODEL1310110062#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110062#
name: inorganic diphosphatase
kinetic law: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:

metaM fad r
is: CHEBI:16238
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01248
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false

metaR NACHEX21ly
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
type: Reaction
modifier: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR r0558
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110062#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
fast: false
reactant: MODEL1310110062#
product: MODEL1310110062#

metaM tdcrn c
name: myristoyl carnitine
is: HMDB05066
has only substance units: false
boundary condition: false
notes: FORMULA: C21H41NO4 CHARGE: 0
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR FAOXC1811603m
product: MODEL1310110062#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation fatty acid
is described by: ECO:0000269
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_944c2f12_8cc8_4923_93bb_8e78b3beb18a
has only substance units: false
is: O75355
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:956
name: ENTPD3

http://identifiers.org/biomodels.db/MODEL1310110062#_293caba7_b407_44a3_828f_1a941146a323
is encoded by: hsa:1635
name: DCTD
initial concentration: NaN
initial amount: NaN
is: P32321
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110062#_7201b1d0_61e2_413a_ac65_cec5145ea077
is encoded by: hsa:AI926493
name: _AI926493_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_6c54001a_4211_42e2_a98b_8074a68b9432
initial concentration: NaN
name: DGKD
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:8527

metaM lnlncacoa c
is: CHEBI:51985
initial concentration: 1.0
is: HMDB06290
name: alpha-Linolenoyl-CoA
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_419768c4_df70_4e49_b823_9925edf8a15f
name: DGKZ
is encoded by: hsa:8525
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is: G3V0F6

http://identifiers.org/biomodels.db/MODEL1310110062#_fa2d986f_6e05_4a1b_8e3f_3927eaf5ab14
initial concentration: NaN
has only substance units: false
is: Q03393
constant: false
name: PTS
initial amount: NaN
type: Species
is encoded by: hsa:5805
boundary condition: true
is: SBO:0000252

metaM C04849 e
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
initial concentration: 1.0
is: CHEBI:57449
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849

metaR EX 3ddcrn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaM tetpent3 c
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
name: tetracosapentaenoic acid, n-3
is: HMDB06323

metaR r0559
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110062#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110062#

metaM fuc12gal14acglcgalgluside hs g
is: HMDB00304
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57847
is: SBO:0000247
boundary condition: false
type: Species
name: Type IIH glycolipid
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_620b5a0a_a839_4640_b34e_1e1cfb2f757e
initial amount: NaN
has only substance units: false
name: B3GALNT1
is: SBO:0000252
type: Species
boundary condition: true
is: B3KTQ4
constant: false
initial concentration: NaN
is encoded by: hsa:8706

metaR r0345
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
product: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:

metaR FAOXC142C142OHm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_8e832fd4_08c0_4179_bb76_c45d634d75b8
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P28332
type: Species
constant: false
is: SBO:0000252
name: ADH6
is encoded by: hsa:130

http://identifiers.org/biomodels.db/MODEL1310110062#_19a12d8a_b6cc_42e2_864e_d3f0fc3043ad
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q8N370
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:124935
name: SLC43A2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_1028a203_6599_4356_bd24_5b5d10957166
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q16698
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: DECR1
is encoded by: hsa:1666

http://identifiers.org/biomodels.db/MODEL1310110062#_bf1deed2_1b1e_4b25_8593_78d9e0fea00a
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1593
initial concentration: NaN
name: CYP27A1
constant: false
is: Q02318
type: Species
is: SBO:0000252

metaR PCHOL HSter
is described by: ECO:0000000
fast: false
name: phosphatidylcholine scramblase
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reactant: MODEL1310110062#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_93623be1_42a2_43aa_9e3d_a99a327ed025
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:586
name: BCAT1
is: P54687
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM ksi pre32 g
boundary condition: false
is: CHEBI:28067
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
name: keratan sulfate I biosynthesis, precursor 32

http://identifiers.org/biomodels.db/MODEL1310110062#_c7a9190f_e715_4b4e_acc9_56ef37208425
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2651
constant: false
has only substance units: false
initial amount: NaN
is: Q08M29
name: GCNT2
type: Species
boundary condition: true

metaM 3ttetddcoa m
has only substance units: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02014
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
type: Species

metaM acgal1p c
constant: false
is: CHEBI:55404
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
initial amount: NaN
initial concentration: 1.0
name: N-Acetyl-D-galactosamine 1-phosphate
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06480
has only substance units: false

metaR r0954
name: MCT 1 Transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
product: MODEL1310110062#
reversible: true

metaM ksi pre19 g
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
initial amount: NaN
constant: false
type: Species
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 19
has only substance units: false
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
boundary condition: false
is: C00130

metaM 3hmbcoa m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB01356
has only substance units: false
is: CHEBI:57312
type: Species
boundary condition: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110062#_20f47ed0_66f3_4c45_80b4_77399ecd5bb6
initial amount: NaN
type: Species
is encoded by: hsa:AA977580
has only substance units: false
name: _AA977580_1_c
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_415c084c_b0c8_4e37_bd27_8235145098e6
constant: false
is encoded by: hsa:23533
initial concentration: NaN
is: SBO:0000297
has only substance units: false
name: PIK3R5:PIK3CG
boundary condition: true
has part: Q8WYR1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_39fe6d05_db6d_4cb0_8d0d_f20a4f275e0f
name: COX4I2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:84701
constant: false
is: Q96KJ9
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_a039d142_ebfa_49e9_b4ee_7c85418e81d1
is: P49189
name: ALDH9A1
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:223
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_84813da5_1d60_43ad_9fd8_5a9bba085846
is: SBO:0000252
is: D3DX95
constant: false
name: CHAT
is encoded by: hsa:1103
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

metaM tetpent3 e
name: tetracosapentaenoic acid, n-3
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB06323

metaM nadh r
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
initial concentration: 1.0
is: CHEBI:57945
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01487
boundary condition: false
name: NADH(2-)

http://identifiers.org/biomodels.db/MODEL1310110062#_4fd9eac2_7a33_4d7b_b97f_901ea1ff1ac7
constant: false
boundary condition: true
is: P09972
name: ALDOC
is encoded by: hsa:230
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r2054
fast: false
product: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
reversible: false

metaR FAOXC12C12OHm
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR PI4P3Kn
is: SBO:0000176
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate 3-kinase, nuclear
fast: false
kinetic law: MODEL1310110062#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD

metaR S6T9g
kinetic law: MODEL1310110062#
product: MODEL1310110062#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is: SBO:0000176
modifier: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false

metaM dcsptn1 e
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
name: docosa-4,7,10,13,16-pentaenoic acid
is: http://identifiers.org/pubchem.compound/5282848
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB13123
initial amount: NaN

metaR GALGALGALTHCRMtg
reactant: MODEL1310110062#
reversible: true
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
is: SBO:0000185
name: galgalgalthcrm hs intracellular transport

metaM ttetddcoa m
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
has only substance units: false
name: trans5,8tetradecadienoylcoa
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB02288

metaR S6TASE10ly
product: MODEL1310110062#
name: galactose-6-sulfate sulfatase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110062#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_b00f842b_c13b_4aae_8ec3_fa4898886a7c
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: P36959
name: GMPR
is encoded by: hsa:2766
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_304a6d2b_a2ad_4b76_9cbc_ed6476b63a2e
initial concentration: NaN
constant: false
is: Q96CA6
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:30
name: ACAA1
is: SBO:0000252

metaR LDH D
reversible: true
name: D-lactate dehydrogenase
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
kinetic law: MODEL1310110062#
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.2.4

metaR NACHEXA15ly
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#

metaM 56dthm c
has only substance units: false
is: HMDB00079
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: 5,6-dihydrothymine
type: Species
initial amount: NaN
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: CHEBI:27468

metaR FACOAL184
is: SBO:0000176
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#
name: fatty-acid--CoA ligase
fast: false
is described by: ECO:0000000

metaM l2fn2m2masn g
initial concentration: 1.0
notes: FORMULA: C68H113N4O49X CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: CHEBI:28067
has only substance units: false
type: Species
initial amount: NaN

metaR UDPACGALtl
fast: false
product: MODEL1310110062#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: udpacgal intracellular transport
is: SBO:0000185
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ

http://identifiers.org/biomodels.db/MODEL1310110062#_b3510887_e7c3_4d30_9ee3_4de5058322cf
boundary condition: true
is: Q53Y41
constant: false
is encoded by: hsa:1644
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: DDC

metaM gdpddman c
constant: false
initial amount: NaN
is: CHEBI:57964
initial concentration: 1.0
has only substance units: false
is: HMDB01346
boundary condition: false
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
is: SBO:0000247
type: Species
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222

metaR FRDPtcr
reversible: true
is: SBO:0000185
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is described by: ECO:0000134
fast: false

metaM dtmp e
is: CHEBI:26999
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP(2-)
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: HMDB01227
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR HISyLATtc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Histidine by y+LAT1 or y+LAT2 transporters in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_bd178faa_f4ae_4a63_82d3_a54cef80cd87
has only substance units: false
is: A8K092
type: Species
name: ATP5A1
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:498

metaR RE1521M
is described by: ECO:0000000
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1521
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR NACDe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR r1609
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_04bc232b_59e7_4521_9702_295911b6f998
initial concentration: NaN
has only substance units: false
name: SULT1A3
constant: false
is: Q1ET61
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6818
type: Species

metaR PPCDC
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176
fast: false
reactant: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
kinetic law: MODEL1310110062#
name: phosphopantothenoylcysteine decarboxylase
product: MODEL1310110062#
is described by: ECO:0000269

metaR GLYtp
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
name: glycine passive transport to peroxisome

metaM 4mlacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB02052
name: 4-maleylacetoacetate
is: CHEBI:17105
boundary condition: false
is: SBO:0000247

metaM gacpail hs c
type: Species
is: C00092
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:61548
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: HMDB01401
name: glucosaminyl-acylphosphatidylinositol

metaM dcsptn1 c
name: docosa-4,7,10,13,16-pentaenoic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: SBO:0000247
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/5282848
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB13123
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_c0e91f80_a1b7_4dbe_b903_57212f1549e4
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:114805
is: SBO:0000252
name: GALNT13
is: Q8IUC8
boundary condition: true
type: Species

metaM cspg e l
is: HMDB02183
constant: false
has only substance units: false
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: CHEBI:36005
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM HC01496 m
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
name: 2-Amino-3-oxoadipate
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28095
initial amount: NaN
type: Species
boundary condition: false

metaR RE3568C
type: Reaction
kinetic law: MODEL1310110062#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3568
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176

metaM succoa m
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
initial concentration: 1.0
constant: false
name: Succinyl-CoA
is: HMDB01022
is: CHEBI:57292

metaM nadh m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: C00004
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
constant: false
is: HMDB01487
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN

metaR C142ACBP
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_cc73f842_6a6a_4a19_8d8e_7125d05de843
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: P23378
has only substance units: false
is encoded by: hsa:2731
initial amount: NaN
name: GLDC
is: SBO:0000252

metaR r1608
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#

metaR EX 3octdece1crn
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_f0514e1f_91c9_42a1_bee4_72c7a6e1a1ea
is: SBO:0000252
is: B3KT70
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:80201
initial amount: NaN
has only substance units: false
name: HKDC1

http://identifiers.org/biomodels.db/MODEL1310110062#_4d784724_6b41_48b1_a816_d63e4e76e27b
boundary condition: true
initial amount: NaN
type: Species
is: P34896
initial concentration: NaN
is encoded by: hsa:6470
name: SHMT1
has only substance units: false
constant: false
is: SBO:0000252

metaM pep m
initial concentration: 1.0
has only substance units: false
name: Phosphoenolpyruvate
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: HMDB00263
boundary condition: false
initial amount: NaN
is: CHEBI:18021
is: C00074
constant: false
is: SBO:0000247
type: Species

metaR r1607
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110062#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110062#
reversible: true

metaR r2060
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110062#_93a3e3b7_1760_40f0_9be5_ffb9a0032f52
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2523
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: FUT1
is: Q6IZA2

metaR r0450
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is: SBO:0000176
reversible: true
modifier: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_abaee872_6b1d_4cc3_a633_e613b406fa45
constant: false
is encoded by: hsa:5106
type: Species
initial concentration: NaN
name: PCK2
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q16822
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_08e6b792_bb5a_43da_9529_262a2da38190
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: ABCB4
is encoded by: hsa:5244
initial concentration: NaN
is: A4D1D5
type: Species
has only substance units: false

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM zymstnl r
has only substance units: false
constant: false
is: CHEBI:16608
initial concentration: 1.0
is: HMDB06841
type: Species
name: 5alpha-cholest-8-en-3beta-ol
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
initial amount: NaN
boundary condition: false

metaR COAtn
name: coenzyme A transport, nuclear
is described by: ECO:0000000
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_cad13057_034d_43cf_9faa_727a95f9fe55
type: Species
constant: false
has only substance units: false
is: O00476
is: SBO:0000252
name: SLC17A3
initial amount: NaN
boundary condition: true
is encoded by: hsa:10786
initial concentration: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR OCTAt
name: Octanoate transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: true
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110062#

metaR DAGKn hs
is described by: ECO:0000269
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
type: Reaction
name: Diacylglycerol phosphate kinase (homo sapiens)
modifier: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.107
fast: false
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

metaR ORNDC
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
modifier: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.17
fast: false
is described by: ECO:0000269
reactant: MODEL1310110062#
name: Ornithine Decarboxylase
product: MODEL1310110062#
type: Reaction

metaR COAtm
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
type: Reaction
reversible: true
name: CoA transporter
reactant: MODEL1310110062#
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is: SBO:0000185
is described by: ECO:0000269

metaM fgam c
boundary condition: false
is: HMDB01308
is: SBO:0000247
initial amount: NaN
is: CHEBI:58426
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: C04376
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_308fc3ee_65b8_47f1_8099_d8bf6110dd7c
initial amount: NaN
is encoded by: hsa:2588
name: GALNS:GLB1:NEU1:CTSA
is encoded by: hsa:4758
is encoded by: hsa:5476
has only substance units: false
initial concentration: NaN
has part: P34059
has part: P16278
has part: P10619
is encoded by: hsa:2720
constant: false
type: Species
boundary condition: true
is: SBO:0000297
has part: Q99519

http://identifiers.org/biomodels.db/MODEL1310110062#_328e267d_2851_45df_9515_90cceaded7e8
initial concentration: NaN
is: B7Z792
is encoded by: hsa:4720
has only substance units: false
boundary condition: true
initial amount: NaN
name: NDUFS2
constant: false
is: SBO:0000252
type: Species

metaR NMNATr
name: nicotinamide-nucleotide adenylyltransferase
product: MODEL1310110062#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.1
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269

metaR r1401
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
name: Facilitated diffusion
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.51
is version of: http://identifiers.org/ec-code/2.7.10.1
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.35
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.41

metaR AG13T5g
reversible: false
reactant: MODEL1310110062#
modifier: MODEL1310110062#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR DNDPt23m
is described by: ECO:0000269
reversible: false
is: SBO:0000185
modifier: MODEL1310110062#
reactant: MODEL1310110062#
name: dTDP transport via dGTP antiport
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110062#
type: Reaction

metaM HC01415 m
is: SBO:0000247
has only substance units: false
boundary condition: false
name: (2E)-Octenoyl-CoA
is: CHEBI:27537
type: Species
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
initial concentration: 1.0
initial amount: NaN

metaR TRPt4
is: SBO:0000185
reversible: false
fast: false
product: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
is described by: ECO:0000304
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
name: L-tryptophan transport in via sodium symport

metaM ctdecdcoa m
is: C08277
is: HMDB00792
initial concentration: 1.0
type: Species
name: cis2trans4decadienoylcoa
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR FAOXC123m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR COAtl
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
is described by: ECO:0000000
name: CoA transport in lysosome via diffusion
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_f1701c7e_28f9_44b8_a9ab_e17b8fbc3e99
name: ALG5
is: Q9Y673
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:29880

metaM fad m
is: SBO:0000247
is: HMDB01248
initial amount: NaN
is: CHEBI:16238
type: Species
boundary condition: false
constant: false
is: C00016
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

http://identifiers.org/biomodels.db/MODEL1310110062#_dc5c1847_2055_4a82_a505_1e40ed8717ac
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:AF080579
name: _AF080579_1_c
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM hexc e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
is: CHEBI:31013
boundary condition: false
is: HMDB02356
has only substance units: false
name: cerotate
constant: false

metaM cysam c
constant: false
type: Species
is: CHEBI:58029
initial amount: NaN
is: SBO:0000247
is: HMDB02991
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
name: cysteaminium
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM 3mop c
boundary condition: false
name: 3-methyl-2-oxopentanoate
type: Species
has only substance units: false
is: HMDB00491
is: CHEBI:28654
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

metaM pmtcrn r
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
has only substance units: false
is: CHEBI:17490
type: Species
name: L-palmitoylcarnitine
constant: false
boundary condition: false
is: HMDB00222
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR SEBACACT
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR DDCRNe
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaR DOPABMO
fast: false
name: dopamine beta-monooxygenase
is: SBO:0000176
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
type: Reaction
kinetic law: MODEL1310110062#
is described by: ECO:0000269
modifier: MODEL1310110062#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.17.1

metaR GGT6
reactant: MODEL1310110062#
product: MODEL1310110062#
name: Gamma-glutamyltransferase
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
is: SBO:0000176
kinetic law: MODEL1310110062#

metaR FAOXC2252053m
reversible: false
fast: false
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000000
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is: SBO:0000176
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110062#_8ba09681_e292_427d_838b_fc4080922195
type: Species
constant: false
name: TXNRD1
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7296

metaR RIBt
is: SBO:0000185
reversible: true
type: Reaction
fast: false
product: MODEL1310110062#
is described by: ECO:0000000
name: ribose transport via diffusion
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_beabfac2_2892_4885_adb4_55702afa7765
constant: false
name: RDH8
initial concentration: NaN
is encoded by: hsa:50700
initial amount: NaN
boundary condition: true
is: Q9NYR8
has only substance units: false
is: SBO:0000252
type: Species

metaM pheme e
is: C00032
is: SBO:0000247
constant: false
name: Protoheme
is: HMDB03178
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:17627
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_0a0402e4_52e8_4ad9_be8c_c0fef4fd18f1
has only substance units: false
is encoded by: hsa:155184
name: SLC2A7
type: Species
is: SBO:0000252
is: Q6PXP3
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaM cbasp e
has only substance units: false
is: CHEBI:32814
is: C00438
name: N-Carbamoyl-L-aspartate
is: HMDB00828
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2
initial amount: NaN

metaR q10h2tc
name: transport of ubiquinol into cytosol
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110062#
type: Reaction
fast: false
reversible: true

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM nadh c
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
is: C00004
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
boundary condition: false
is: CHEBI:57945
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
type: Species
initial concentration: 1.0
is: CHEBI:26174
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaR H2O2t
product: MODEL1310110062#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110062#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
kinetic law: MODEL1310110062#
name: hydrogen peroxide transport via diffusion
reversible: true

metaR r1400
is: SBO:0000185
name: Active transport
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reactant: MODEL1310110062#
product: MODEL1310110062#
kinetic law: MODEL1310110062#

metaM hexc c
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
boundary condition: false
has only substance units: false
name: cerotate
type: Species
initial concentration: 1.0
is: HMDB02356
is: CHEBI:31013

metaM mi1345p c
has only substance units: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: SBO:0000247
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: CHEBI:57895
initial concentration: 1.0
is: HMDB01059

metaR AMETr
kinetic law: MODEL1310110062#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110062#
reactant: MODEL1310110062#
name: S-Adenosyl-L-methionine intracellular diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
type: Reaction

metaR PPM
reversible: true
modifier: MODEL1310110062#
name: phosphopentomutase
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/5.4.2.2
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176

metaM xyl D e
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
is: CHEBI:15936
name: aldehydo-D-xylose

http://identifiers.org/biomodels.db/MODEL1310110062#_1729267c_d547_4c5d_aa2e_2503cedd57ce
type: Species
is: E9KL42
constant: false
is encoded by: hsa:641371
name: ACOT1
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_7db734d7_0796_4d0d_bbf2_103e196ba299
has only substance units: false
is: P42765
type: Species
boundary condition: true
constant: false
is encoded by: hsa:10449
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ACAA2

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_8a581108_96f8_4340_a784_dfe38c694ac7
boundary condition: true
name: NDUFS4
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4724
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: O43181

metaR PPAt
product: MODEL1310110062#
type: Reaction
is: SBO:0000185
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
name: Propionate transport, diffusion
reactant: MODEL1310110062#
fast: false

metaR 2DR1PP
is: SBO:0000176
kinetic law: MODEL1310110062#
fast: false
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_b28876e1_8a7c_4035_9076_36f508ad44f5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1349
boundary condition: true
name: COX7B
initial concentration: NaN
is: P24311
type: Species
initial amount: NaN
constant: false

metaR NDPK3n
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110062#
product: MODEL1310110062#
fast: false
reversible: true
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
type: Species
boundary condition: false
has only substance units: false
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
is: SBO:0000247
is: CHEBI:26174

metaR RE0830N
product: MODEL1310110062#
modifier: MODEL1310110062#
type: Reaction
reversible: true
kinetic law: MODEL1310110062#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110062#
name: RE0830

metaR FUMAC
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.7.1.2
reversible: false
is: SBO:0000176
fast: false
name: fumarylacetoacetase

metaR NMNATn
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.7.1
modifier: MODEL1310110062#
fast: false
reversible: false
name: nicotinamide-nucleotide adenylyltransferase
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES:IT
kinetic law: MODEL1310110062#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_166586a2_5b47_487f_b9a5_481209a667ca
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: A8K8P8
name: FUT8
constant: false
is encoded by: hsa:2530
has only substance units: false

metaM pheme c
constant: false
has only substance units: false
boundary condition: false
is: HMDB03178
type: Species
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
name: Protoheme
is: CHEBI:17627
initial concentration: 1.0
initial amount: NaN
is: C00032
is: SBO:0000247

metaM cbasp c
name: N-Carbamoyl-L-aspartate
initial amount: NaN
is: CHEBI:32814
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
boundary condition: false
is: C00438
is: HMDB00828
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_845bd844_3320_41d2_9763_68ace453abbf
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: PEMT
is encoded by: hsa:10400
initial concentration: NaN
boundary condition: true

metaM dcyt c
is: C00881
constant: false
initial concentration: 1.0
initial amount: NaN
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:15698
is: HMDB00014
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110062#_57fa63db_d573_4105_986a_7f1e019e2d7f
initial amount: NaN
is encoded by: hsa:5244
is: P21439
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: ABCB4

metaM chlstol r
constant: false
initial amount: NaN
is: HMDB06842
boundary condition: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial concentration: 1.0
is: CHEBI:16290
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439

metaM dcamp c
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
boundary condition: false
has only substance units: false
is: CHEBI:57567
initial amount: NaN
is: C03794
initial concentration: 1.0
constant: false
name: N6-(1,2-Dicarboxyethyl)-AMP
is: SBO:0000247
type: Species
is: HMDB00536

metaR r1931
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
fast: false
modifier: MODEL1310110062#
reversible: false

metaM mi134p c
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: CHEBI:58414
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: HMDB01143

metaM tetdecdicoa m
type: Species
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB02288
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 5,8-tetradecadienoylcoa

metaM lgnccoa x
constant: false
is: HMDB06526
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
name: lignocericyl coenzyme A
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM xyl D c
is: SBO:0000247
type: Species
name: aldehydo-D-xylose
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:15936
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110062#_c8e94f8a_bf3e_4023_a428_e7db0eb80c5d
initial concentration: NaN
is encoded by: hsa:3422
is: Q13907
name: IDI1
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_ef6b2637_4dc1_4d5c_8b38_bfcfd4fd0e0a
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3145
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P08397
name: HMBS

metaM g3p c
name: Glyceraldehyde 3-phosphate
has only substance units: false
is: CHEBI:58027
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3930
is: C00661
is: HMDB01112

metaR MM7Cbg
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
modifier: MODEL1310110062#
is: SBO:0000176

metaR DGK1
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110062#
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: deoxyguanylate kinase (dGMP:ATP)
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.4.8
fast: false

metaM ksi pre16 g
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 16
is: SBO:0000247
is: CHEBI:58053
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
is: C00130
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110062#_64a81bff_6863_46d0_878c_8225bc0260cb
initial amount: NaN
constant: false
is encoded by: hsa:2182
has only substance units: false
is: Q5JWV8
is: SBO:0000252
boundary condition: true
name: ACSL4
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_f1d0b8b4_e580_4817_a0f6_42fba31180fd
is encoded by: hsa:50
type: Species
has only substance units: false
is: Q99798
name: ACO2
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR FAOXC8C6m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR r1823
kinetic law: MODEL1310110062#
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110062#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FAOXC11C9m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaR DPHMBDCm
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
reversible: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
is: SBO:0000176
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is described by: ECO:0000000
fast: false
type: Reaction

metaM HC01408 m
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial amount: NaN
type: Species
is: CHEBI:27648
has only substance units: false
constant: false
name: 3-Oxohexanoyl-CoA
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM fad c
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
type: Species
is: HMDB01248
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM C05957 r
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: Prostaglandin J2
constant: false
is: HMDB02710
is: CHEBI:27485
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_9071e162_3540_4494_94b8_bbe348941c81
is: SBO:0000252
type: Species
is encoded by: hsa:5288
is: O75747
constant: false
has only substance units: false
boundary condition: true
name: PIK3C2G
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_959df5a6_8adc_4fa5_a459_0bd0a4a50d32
name: SUCLG1:SUCLA2
initial concentration: NaN
type: Species
has part: E5KS60
constant: false
initial amount: NaN
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:8803

metaM pep c
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial amount: NaN
constant: false
is: CHEBI:18021
type: Species
initial concentration: 1.0
is: C00074
is: SBO:0000247
boundary condition: false
name: Phosphoenolpyruvate
has only substance units: false
is: HMDB00263

metaM 3mop m
boundary condition: false
type: Species
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
is: CHEBI:28654
is: HMDB00491
has only substance units: false
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: SBO:0000247
initial amount: NaN

metaR RE0926E
product: MODEL1310110062#
type: Reaction
name: RE0926
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaR r1937
product: MODEL1310110062#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
fast: false
reactant: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110062#

metaM CE4872 m
type: Species
is: HMDB00127
has only substance units: false
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
boundary condition: false
is: CHEBI:15748
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872

metaR r1610
product: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 3hexdcoa m
is: HMDB03932
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
name: 3-hydroxyhexadecanoylcoa
initial amount: NaN
is: C05258
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110062#_8d95d8d6_2d14_4876_9ad6_79785ddecec0
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:23236
has only substance units: false
boundary condition: true
type: Species
name: PLCB1

http://identifiers.org/biomodels.db/MODEL1310110062#_5759def4_fdbb_4adf_b7e5_abe8ab130fa1
constant: false
is: P22352
boundary condition: true
is encoded by: hsa:2878
type: Species
initial concentration: NaN
name: GPX3
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR TDPm
type: Reaction
reversible: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
product: MODEL1310110062#
name: thiamin pyrophosphatase, mitochondrial
kinetic law: MODEL1310110062#
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaM CE2431 m
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
type: Species
name: cis-deca-4-enoyl-CoA
is: CHEBI:57795
initial amount: NaN
boundary condition: false
has only substance units: false

metaM fad e
constant: false
name: Flavin adenine dinucleotide oxidized
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
initial amount: NaN
is: C00016
is: HMDB01248
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16238

metaR CHOLt4
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110062#
type: Reaction
name: choline, sodium cotransport
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
kinetic law: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#
reactant: MODEL1310110062#

metaR MMSAD1m
is version of: http://identifiers.org/ec-code/1.2.1.27
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
type: Reaction
name: methylmalonate-semialdehyde dehydrogenase
reversible: false
fast: false
modifier: MODEL1310110062#
reactant: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000176
is described by: ECO:0000269

metaR 5MTHFt
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110062#
reactant: MODEL1310110062#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
fast: false
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110062#_348506b2_21a5_4798_b357_6a73c03ea3ad
initial concentration: NaN
name: PLCZ1
is encoded by: hsa:89869
is: Q86YW0
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR H2Otly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is: SBO:0000185
name: H2O transport, lysosomal
reversible: true
type: Reaction

metaM lneldccrn c
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Linoelaidyl carnitine
is: HMDB06461
initial concentration: 1.0

metaM ksii core2 deg6 l
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 6
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: HMDB00143
boundary condition: false
is: CHEBI:12936
has only substance units: false

metaR r0801
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
kinetic law: MODEL1310110062#
is: SBO:0000185
fast: false
product: MODEL1310110062#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
modifier: MODEL1310110062#

metaM uppg3 c
initial amount: NaN
initial concentration: 1.0
type: Species
name: Uroporphyrinogen III
is: HMDB01086
is: SBO:0000247
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
has only substance units: false
constant: false
is: C01051
boundary condition: false
is: CHEBI:57308

metaR BDHm
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is: SBO:0000176
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.1.1.30
kinetic law: MODEL1310110062#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_c4938df1_1d5f_431d_ac37_1a360beaa135
constant: false
boundary condition: true
has only substance units: false
name: NDUFA13
initial concentration: NaN
is: Q9P0J0
is encoded by: hsa:51079
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_98ef0cdb_d441_4121_b43f_3dee5c0adcda
is encoded by: hsa:514
initial amount: NaN
name: ATP5E
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false

metaM ksi pre9 g
name: keratan sulfate I biosynthesis, precursor 9
initial amount: NaN
has only substance units: false
constant: false
is: C00130
boundary condition: false
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: SBO:0000247
is: CHEBI:58053
initial concentration: 1.0
type: Species
is: HMDB00175

W3 CDTF: Thu Aug 30 23:21:49 BST 2012

metaM pheme m
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:17627
name: Protoheme
is: HMDB03178
is: C00032

metaR CMPSASn
name: CMP sialic acid synthase, nuclear
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.43
modifier: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
fast: false
reversible: false
kinetic law: MODEL1310110062#

metaR AG13T10g
reactant: MODEL1310110062#
is: SBO:0000176
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
modifier: MODEL1310110062#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110062#

W3 CDTF: Thu Aug 30 23:21:50 BST 2012

metaR COAtr
name: COA transporter, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction

metaR ITCOAL1m
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
is described by: ECO:0000304
is: SBO:0000176
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
reversible: true
modifier: MODEL1310110062#
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110062#

metaM CE5119 m
boundary condition: false
name: trans-3-cis-8-tetradecadienoyl-CoA
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57923
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
initial amount: NaN
type: Species
initial concentration: 1.0

metaR NACHEXA11ly
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110062#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
is: SBO:0000176
product: MODEL1310110062#
kinetic law: MODEL1310110062#
type: Reaction

metaR KSIt
reversible: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110062#
is: SBO:0000185
product: MODEL1310110062#
type: Reaction
fast: false
is described by: ECO:0000000
name: keratan sulfate I transport, golgi to extracellular

W3 CDTF: Thu Aug 30 23:21:49 BST 2012

metaM 3mldz c
has only substance units: false
name: 1-methylimidazole-4-acetaldehyde
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
type: Species
constant: false
is: HMDB04181
is: CHEBI:28104

metaR FAOXC226
product: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
modifier: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false

metaM leu L m
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
initial amount: NaN
name: L-leucine
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00687

metaM amp c
is: CHEBI:3322
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00045
is: C00020
name: AMP

metaM xyl D l
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial amount: NaN
constant: false
name: aldehydo-D-xylose
type: Species
boundary condition: false
is: CHEBI:15936
has only substance units: false

metaR GLYC3PFADm
is described by: ECO:0000134
name: glycerophosphate shuttle for trasnfer of reducing equivalents
reactant: MODEL1310110062#
reversible: false
product: MODEL1310110062#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_c04d32e7_b844_4203_a66f_1680f2b46c34
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: O75947
has only substance units: false
initial amount: NaN
name: ATP5H
is encoded by: hsa:10476
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110062#_d8e9b65a_22bd_4050_882c_9e8fbb7513d3
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI761708
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _AI761708_1_m

metaR CREATt4 2 r
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000269
type: Reaction
name: Creatine transport (sodium symport) (2:1)
modifier: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_34f676a3_9ac0_4881_9243_ec13f79fd6a8
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:57786
name: RBAK
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9NYW8

metaM docohepcoa m
type: Species
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
constant: false
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB06294
is: SBO:0000247

metaM dump c
initial concentration: 1.0
has only substance units: false
is: CHEBI:246422
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
constant: false
is: HMDB01409
boundary condition: false
is: C00365

http://identifiers.org/biomodels.db/MODEL1310110062#_cb2fb97b_6b19_4978_ae80_c9d163feb0a8
boundary condition: true
name: DGKE
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:8526
initial amount: NaN
is: SBO:0000252
constant: false
is: A1L4Q0

http://identifiers.org/biomodels.db/MODEL1310110062#_92c22be0_4df7_4af6_9386_79ade4fe94a1
is encoded by: hsa:9962
has only substance units: false
initial concentration: NaN
is: Q9UGH3
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: SLC23A2

metaR r0456
reversible: false
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.1.32
kinetic law: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#
type: Reaction
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
fast: false
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
product: MODEL1310110062#

http://identifiers.org/biomodels.db/MODEL1310110062#_9d7faff6_e6e4_4549_9ff9_f3d8ab1ad4c2
is encoded by: hsa:9990
is: SBO:0000252
initial concentration: NaN
is: Q9UHW9
boundary condition: true
name: SLC12A6
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM thp2c x
type: Species
boundary condition: false
is: HMDB12130
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
name: 1-piperideine-6-carboxylate
initial amount: NaN
has only substance units: false
is: CHEBI:16987

metaR COAtp
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: coenzyme A transport, peroxisomal

metaR ABUTD
type: Reaction
modifier: MODEL1310110062#
name: Aminobutyraldehyde dehydrogenase
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
kinetic law: MODEL1310110062#
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM CE2422 m
is: CHEBI:28387
boundary condition: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
constant: false
has only substance units: false
is: HMDB11123
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_0be02366_4f98_4f13_b14b_f70ef3162d71
is: SBO:0000252
constant: false
boundary condition: true
is: Q99714
name: HSD17B10
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3028

metaR ACACt2
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
product: MODEL1310110062#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
type: Reaction
is: SBO:0000185
modifier: MODEL1310110062#
is described by: ECO:0000269
name: acetoacetate transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110062#_0ae495fe_16e0_4768_9bd3_ab881c72ab9a
type: Species
initial concentration: NaN
boundary condition: true
name: RRM2B
is encoded by: hsa:50484
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q7LG56

metaM HC01842 c
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: Phosphodimethylethanolamine
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:31997

metaM decdp c
constant: false
is: HMDB06288
is: SBO:0000247
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
has only substance units: false
initial amount: NaN
name: all trans Decaprenyl diphosphate
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_696f56ce_589b_4911_9d99_21c0cd088f1f
is encoded by: hsa:BE042354
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: _BE042354_1_m
has only substance units: false
initial concentration: NaN

metaR GK1
reactant: MODEL1310110062#
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.8
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
name: guanylate kinase (GMP:ATP)
product: MODEL1310110062#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_0501406b_2f14_4377_94d4_f661952bcacf
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4513
name: COX2
initial concentration: NaN
is: Q7GXZ8
has only substance units: false
is: SBO:0000252
boundary condition: true

W3 CDTF: Thu Aug 30 23:21:50 BST 2012

metaR r0560
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
kinetic law: MODEL1310110062#
is: SBO:0000176

metaM dlnlcgcoa r
type: Species
constant: false
boundary condition: false
name: dihomo-gamma-linolenyl coenzyme A
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27979
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: C03595
has only substance units: false

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaM amp e
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
is: CHEBI:456215
is: SBO:0000247
constant: false
type: Species
is: C00020
name: AMP
is: HMDB00045
boundary condition: false
initial amount: NaN

metaM dttp n
is: CHEBI:37568
initial concentration: 1.0
name: dTTP
is: C00459
is: SBO:0000247
is: HMDB01342
constant: false
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
type: Species
initial amount: NaN

metaM co2 e
is: HMDB01967
has only substance units: false
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00011
is: SBO:0000247
type: Species
name: CO2

metaM cmp e
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:60377
is: HMDB00095
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
name: CMP(2-)

metaM CE5236 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28002
is: SBO:0000247
constant: false

metaR r1616
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#
fast: false
type: Reaction

metaR r0021
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#
type: Reaction
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110062#
is: SBO:0000176
modifier: MODEL1310110062#
fast: false
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7

http://identifiers.org/biomodels.db/MODEL1310110062#_55332b6c_b593_438b_ae36_3e9ad1eb6980
has only substance units: false
constant: false
name: PIK3C2A
is encoded by: hsa:5286
boundary condition: true
is: O00443
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM 34dhoxpeg e
name: 3,4-Dihydroxyphenylethyleneglycol
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/7902
is: HMDB00318
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C05576
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576

metaM udpgal g
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00302
initial amount: NaN
is: CHEBI:58439
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
is: SBO:0000247
name: UDP-D-galactose(2-)

metaM ala L m
name: L-alanine
is: HMDB00161
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:16977
constant: false

metaR F1PGT
is: SBO:0000176
reactant: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#
fast: false
reversible: true
kinetic law: MODEL1310110062#
product: MODEL1310110062#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.30
name: fucose-1-phosphate guanylyltransferase
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110062#_metaR_EX_acnacngal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3',8'-LD1 exchange
type: Reaction

metaR C226CPT2
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: false
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
name: C226 transport into the mitochondria
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110062#_827a9ab8_793b_4277_aa3f_cbdf4a6aedee
boundary condition: true
has only substance units: false
type: Species
name: AK4
constant: false
is: P27144
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:205
initial amount: NaN

metaM dttp c
boundary condition: false
constant: false
initial concentration: 1.0
is: C00459
is: CHEBI:37568
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01342
has only substance units: false
name: dTTP

metaM gly c
initial concentration: 1.0
boundary condition: false
is: HMDB00123
is: C00037
name: Glycine
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:3339
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaM leuktrC4 r
constant: false
initial concentration: 1.0
is: CHEBI:57973
is: HMDB01198
has only substance units: false
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: SBO:0000247
name: leukotriene C4(2-)
initial amount: NaN
boundary condition: false

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR GTHP
product: MODEL1310110062#
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.9
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.15
reactant: MODEL1310110062#
fast: false
reversible: true
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.11.1.12

metaR r0022
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110062#
fast: false
type: Reaction
product: MODEL1310110062#
kinetic law: MODEL1310110062#
is: SBO:0000176
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110062#

metaR r1615
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
reversible: true
reactant: MODEL1310110062#
product: MODEL1310110062#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110062#_0126a5ac_a31c_4e11_9032_88aa5e67060c
name: AKR7A2
is: O43488
is encoded by: hsa:8574
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR P45027A1m
product: MODEL1310110062#
reversible: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: Cytochrome P450 27
fast: false
is described by: ECO:0000269
is: SBO:0000176

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR TRPHYDRO2
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
type: Reaction
modifier: MODEL1310110062#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.14.16.4

http://identifiers.org/biomodels.db/MODEL1310110062#_4bd773f1_b79e_4690_9321_59c3e4211e3a
name: ALPP
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P05187
is encoded by: hsa:250

metaR r0960
is: SBO:0000185
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_44ffc567_00b6_4fb6_be8a_5dee87ceaa48
is: Q5TDP6
is: SBO:0000252
boundary condition: true
name: LGSN
is encoded by: hsa:51557
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110062#
fast: false
kinetic law: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
product: MODEL1310110062#
is described by: ECO:0000304
reversible: true
reactant: MODEL1310110062#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is: SBO:0000176

metaR CYTDt
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110062#
fast: false
type: Reaction
name: cytidine facilated transport in cytosol
kinetic law: MODEL1310110062#
product: MODEL1310110062#
is: SBO:0000185
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

metaM cmp g
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
type: Species
is: CHEBI:60377
initial amount: NaN
name: CMP(2-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00095
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_91a395fe_9f65_401f_ba72_32eac04d9223
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:5150
name: PDE7A
boundary condition: true
initial amount: NaN
constant: false

metaR GTHO
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione oxidoreductase
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
reversible: false
modifier: MODEL1310110062#
fast: false
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2

metaM 34dhoxpeg c
constant: false
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/7902
type: Species
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
initial amount: NaN
name: 3,4-Dihydroxyphenylethyleneglycol
initial concentration: 1.0
is: C05576
is: HMDB00318
is: SBO:0000247

metaR r1618
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110062#
modifier: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110062#_6c4c40e8_46f9_4272_b44c_0df475ae2413
type: Species
is encoded by: hsa:275
has part: P23434
constant: false
initial amount: NaN
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:2731
is: SBO:0000297
has only substance units: false
boundary condition: true
is encoded by: hsa:2653
has part: P23378
has part: P48728
initial concentration: NaN

metaM ha pre1 l
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: CHEBI:16126
constant: false
is: SBO:0000247
name: hyaluronan biosynthesis, precursor 1
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM tre e
is: SBO:0000247
has only substance units: false
is: C01083
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: Trehalose
is: HMDB00975
is: CHEBI:16551

metaM c226coa c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
constant: false
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110062#_db95a89f_355d_4ca1_9c70_576fe2120f4c
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: P11166
initial concentration: NaN
constant: false
is encoded by: hsa:6513
name: SLC2A1

http://identifiers.org/biomodels.db/MODEL1310110062#_0186fe44_b973_4ff5_a596_61964b4680ee
has only substance units: false
initial amount: NaN
is encoded by: hsa:8706
initial concentration: NaN
name: B3GALNT1
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: O75752

metaR XYLTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
name: Xylitol transport via passive diffusion
reversible: true
is: SBO:0000185
product: MODEL1310110062#
kinetic law: MODEL1310110062#
fast: false
type: Reaction
reactant: MODEL1310110062#
is described by: ECO:0000000

metaR FAOXC185C164m
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaM gly e
is: SBO:0000247
initial concentration: 1.0
is: C00037
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0
type: Species
name: Glycine
has only substance units: false
is: CHEBI:3339
boundary condition: false
initial amount: NaN
is: HMDB00123

http://identifiers.org/biomodels.db/MODEL1310110062#_593c4dd3_1bfe_4d59_84d5_0fa517a92c92
has part: A7E2E0
is encoded by: hsa:5293
type: Species
has only substance units: false
has part: Q92569
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:8503
name: PIK3CD:PIK3R3

metaM ksii core2 g
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57255
is: SBO:0000247
is: HMDB01014
type: Species
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)

metaM dutp n
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB01191
initial amount: NaN

metaR ASCBt4
is: SBO:0000185
name: L-ascorbate transport via proton symport
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#
kinetic law: MODEL1310110062#
reversible: true
modifier: MODEL1310110062#

metaM c12dccoa c
constant: false
is: HMDB00623
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
initial amount: NaN
name: dodecanedioylcoa
initial concentration: 1.0
type: Species

metaR r0961
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110062#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction
fast: false
reactant: MODEL1310110062#

metaM 2dpmhobq m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: SBO:0000247
is: CHEBI:50771
constant: false
has only substance units: false
is: HMDB06484
type: Species
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+

http://identifiers.org/biomodels.db/MODEL1310110062#_eef1e6ef_e6a8_4831_b14c_dfb73d46fb17
initial amount: NaN
is encoded by: hsa:7054
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: TH
type: Species
boundary condition: true

metaR ACACT10m
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reversible: true
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110062#
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110062#

metaM succ x
is: C00042
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00254
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate

metaR HMGCOAtm
product: MODEL1310110062#
fast: false
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000185
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
reactant: MODEL1310110062#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD

metaM 5adtststerones e
has only substance units: false
name: 5alpha-Dihydrotestosterone sulfate
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial concentration: 1.0
is: HMDB06278

metaR r1617
kinetic law: MODEL1310110062#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110062#
reactant: MODEL1310110062#

metaM pyr m
type: Species
is: HMDB00243
name: pyruvate
constant: false
is: CHEBI:15361
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN
is: C00022

metaM 3mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
initial concentration: 1.0
type: Species
is: CHEBI:57344
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01493
boundary condition: false
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110062#_670a08b0_ce0c_49b6_92c3_23e44e8012f2
initial concentration: NaN
is encoded by: hsa:55907
initial amount: NaN
type: Species
name: CMAS
is: Q8NFW8
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR M13N2Tg
reactant: MODEL1310110062#
reversible: false
fast: false
kinetic law: MODEL1310110062#
type: Reaction
is: SBO:0000176
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.101
modifier: MODEL1310110062#
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD

metaR NADtn
is described by: ECO:0000000
name: NAD transport, nuclear through pores
is: SBO:0000185
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
product: MODEL1310110062#
reactant: MODEL1310110062#
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110062#_7c4b2c3d_6452_490e_877b_c479d9a56884
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P11168
initial concentration: NaN
name: SLC2A2
is encoded by: hsa:6514
type: Species

metaM phe L c
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: L-phenylalanine
has only substance units: false
is: CHEBI:17295
is: HMDB00159
boundary condition: false

metaR C226CPT1
product: MODEL1310110062#
fast: false
reactant: MODEL1310110062#
name: carnitine C22:6 transferase
modifier: MODEL1310110062#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110062#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110062#_43de29ca_a876_4232_929a_7d23aa045526
boundary condition: true
is: SBO:0000252
name: ALDH1A1
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:216
is: P00352
has only substance units: false

metaM 5adtststerone c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB02961
constant: false
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: SBO:0000247
type: Species

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM dutp m
is: CHEBI:17625
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
initial amount: NaN
constant: false
is: HMDB01191
name: dUTP
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110062#_9d245186_ebec_427b_9699_4fb7a7d43f81
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: RPN2
initial concentration: NaN
has only substance units: false
is: P04844
constant: false
is encoded by: hsa:6185
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_713361ac_1e81_4daf_950a_08b8520c7f67
initial concentration: NaN
constant: false
boundary condition: true
is: P16260
is: SBO:0000252
has only substance units: false
name: SLC25A16
is encoded by: hsa:8034
type: Species
initial amount: NaN

metaR MG2er
fast: false
product: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110062#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
modifier: MODEL1310110062#
reversible: true
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
kinetic law: MODEL1310110062#

metaR r0249
kinetic law: MODEL1310110062#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is: SBO:0000176
reactant: MODEL1310110062#
is described by: ECO:0000000
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110062#
fast: false
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6

http://identifiers.org/biomodels.db/MODEL1310110062#_3e2a55b2_4275_4024_af18_13dbc1681363
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:6390
initial amount: NaN
name: SDHB
is: P21912
initial concentration: NaN
constant: false
boundary condition: true

metaR r1612
reactant: MODEL1310110062#
product: MODEL1310110062#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110062#
modifier: MODEL1310110062#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR M1316Mg
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
fast: false
type: Reaction
kinetic law: MODEL1310110062#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.114
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
product: MODEL1310110062#
modifier: MODEL1310110062#

metaR PIPLCn
modifier: MODEL1310110062#
reversible: false
product: MODEL1310110062#
name: phosphatidylinositol phospholipase C, nucleus
is described by: ECO:0000000
reactant: MODEL1310110062#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110062#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD

metaR C10OHc
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM CE4794 m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial amount: NaN
is: CHEBI:57923
name: cis-6-dodecenoyl-CoA
has only substance units: false

metaM amp m
has only substance units: false
type: Species
is: CHEBI:456215
constant: false
boundary condition: false
name: AMP(2-)
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
initial concentration: 1.0
is: HMDB00045

metaR r0354
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110062#
is: SBO:0000176
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110062#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110062#
reversible: false
modifier: MODEL1310110062#
type: Reaction

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_a0170eb6_4777_4c44_8763_a9fd6d47e454
constant: false
initial amount: NaN
is encoded by: hsa:1892
is: SBO:0000252
name: ECHS1
type: Species
has only substance units: false
initial concentration: NaN
is: P30084
boundary condition: true

metaM leu L c
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
is: SBO:0000247
initial amount: NaN
is: CHEBI:15603
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: L-leucine

http://identifiers.org/biomodels.db/MODEL1310110062#_c7a52bae_2807_4c89_8180_c1bde438fc72
name: PDE7B
is: Q9NP56
is encoded by: hsa:27115
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r0818
reversible: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
fast: false
is described by: ECO:0000000
product: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
name: Transport reaction
type: Reaction
is: SBO:0000185

metaM udpgal c
is: CHEBI:58439
boundary condition: false
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: HMDB00302

metaM ksii core2 e
name: keratan sulfate II (core 2-linked)
is: HMDB00211
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:17268
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: SBO:0000247

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaM bildglcur c
boundary condition: false
constant: false
is: HMDB03325
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
type: Species
has only substance units: false

metaR PRODt2r
modifier: MODEL1310110062#
reversible: true
name: D-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
kinetic law: MODEL1310110062#
type: Reaction
reactant: MODEL1310110062#
fast: false
is: SBO:0000185
product: MODEL1310110062#
is described by: ECO:0000304

metaR r0355
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110062#
product: MODEL1310110062#
reactant: MODEL1310110062#
modifier: MODEL1310110062#
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction

metaR r1611
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110062#
is: SBO:0000185
kinetic law: MODEL1310110062#
reversible: true
fast: false

metaR r0139
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110062#
type: Reaction
modifier: MODEL1310110062#
is: SBO:0000176
reactant: MODEL1310110062#
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110062#
reversible: true
fast: false
is described by: ECO:0000000

metaM glyc e
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial concentration: 1.0
has only substance units: false
name: Glycerol
is: HMDB00131
is: CHEBI:17754
type: Species
is: C00116
is: SBO:0000247

metaM m4masn g
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C46H77N2O35X CHARGE: 0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
is: C05881

metaM 5adtststerone e
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16330
is: HMDB02961
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247

metaM HC01231 m
constant: false
initial concentration: 1.0
is: CHEBI:58480
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
name: N-[(R)-pantothenoyl]-L-cysteinate

metaR GLCMter
type: Reaction
name: glucose transport via membrane vesicle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
fast: false
is: SBO:0000185
reactant: MODEL1310110062#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110062#
product: MODEL1310110062#

metaM adrnl c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:33568
boundary condition: false
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
type: Species
is: HMDB00068
has only substance units: false
name: Adrenaline
initial amount: NaN
constant: false

metaM phe L e
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:17295
name: L-phenylalanine
has only substance units: false
is: HMDB00159
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079

http://identifiers.org/biomodels.db/MODEL1310110062#_4028bc27_467d_482f_a33d_eea0ec537ff5
has only substance units: false
boundary condition: true
is: Q7KZA3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:2235
name: FECH

http://identifiers.org/biomodels.db/MODEL1310110062#_fc9e39d9_23eb_4894_b80e_2113269975aa
type: Species
is: Q96CD2
name: PPCDC
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:60490
boundary condition: true
initial concentration: NaN

metaM 2mop c
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: HMDB01172
name: 2-methyl-3-oxopropanoate
constant: false
is: CHEBI:57700

metaM c101crn e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C17H31NO4 CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
has only substance units: false
is: HMDB13205
name: decenoyl carnitine

metaM udp l
name: UDP(3-)
is: SBO:0000247
is: CHEBI:58223
constant: false
is: HMDB00295
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110062#_2523c1e6_13d2_4b9e_9fce_f76c9e54d280
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:284098
constant: false
name: PIGW
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q7Z7B1

metaR r1614
kinetic law: MODEL1310110062#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110062#
type: Reaction
is: SBO:0000185
fast: false

metaR APOC LYS BTNPm
fast: false
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
is described by: ECO:0000000
name: proteolysis of apoC-Lys-btn, mitochondrial
product: MODEL1310110062#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
type: Reaction

metaR r0027
modifier: MODEL1310110062#
fast: false
product: MODEL1310110062#
reactant: MODEL1310110062#
type: Reaction
kinetic law: MODEL1310110062#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39

http://identifiers.org/biomodels.db/MODEL1310110062#_9cdba558_0899_40f1_b4f6_cd004ceafe1c
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:9551
name: ATP5J2
has only substance units: false
is: Q6IBB3
boundary condition: true
initial amount: NaN

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110062#
reactant: MODEL1310110062#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110062#_014e236b_60a5_4258_a0ff_86192a168a73
is: O76062
type: Species
boundary condition: true
is: SBO:0000252
name: TM7SF2
initial concentration: NaN
is encoded by: hsa:7108
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110062#_3f0d7104_0b4a_4dec_99db_429f1e8f448a
is encoded by: hsa:9517
initial amount: NaN
name: SPTLC1:SPTLC2
has part: O15270
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000297
has part: O15269
constant: false
is encoded by: hsa:10558