metaM datp n
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:61404
has only substance units: false
is: C00131
name: dATP
constant: false
is: HMDB01532

metaM arachcrn c
is: SBO:0000247
name: arachidyl carnitine
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial amount: NaN
is: HMDB06460
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_3d412234_17f0_4e42_b9fe_2b173029a49a
type: Species
is encoded by: hsa:3939
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: LDHA
constant: false
is: P00338

metaM 2hb c
name: 2-Hydroxybutyrate
is: HMDB00008
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
boundary condition: false
is: CHEBI:1148
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

W3 CDTF: Fri Aug 31 01:17:36 BST 2012

metaM gluside hs r
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:18368
has only substance units: false
initial concentration: 1.0
type: Species

metaM HC02193 c
has only substance units: false
constant: false
name: glycolithocholate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1
is: CHEBI:60008
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_8a818616_0afc_4ece_8d35_044f798df821
is encoded by: hsa:H53099
boundary condition: true
constant: false
name: _H53099_1_m
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM h2o2 n
is: HMDB03125
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
name: hydrogen peroxide
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16240

metaR CYSO
modifier: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is version of: http://identifiers.org/ec-code/1.13.11.20
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110060#
name: cysteine oxidase
fast: false
product: MODEL1310110060#

metaM dmnoncrn m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
boundary condition: false
has only substance units: false
is: HMDB06202
initial concentration: 1.0
constant: false
name: 4,8 dimethylnonanoyl carnitine
type: Species

metaR MAN1PT2
modifier: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: false
name: mannose-1-phosphate guanylyltransferase (GDP)
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.13
fast: false
reactant: MODEL1310110060#
is: SBO:0000176

metaR PI345P5P
is: SBO:0000176
product: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110060#

metaM core2 g
type: Species
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
initial amount: NaN
name: Core 2
is: CHEBI:15876
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_49bdf3fc_4ab4_48de_a8d8_7752af1a0d35
initial concentration: NaN
is encoded by: hsa:D87002
name: _D87002_1_e
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM retinol cis 11 e
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06216
boundary condition: false
name: 11-cis-retinol
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16302

metaR r1568
fast: false
kinetic law: MODEL1310110060#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110060#

metaR FAOXC16OHC16r
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM o2 m
is: SBO:0000247
type: Species
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
boundary condition: false
has only substance units: false
constant: false
is: HMDB01377
name: O2
initial amount: NaN
initial concentration: 1.0

metaR DM fol
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR r0587
fast: false
modifier: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is: SBO:0000176
product: MODEL1310110060#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_ce2b534d_abb6_4392_955e_3240507489ce
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: HAO2
type: Species
is encoded by: hsa:51179
initial concentration: NaN
boundary condition: true

metaM mi14p c
is: SBO:0000247
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00968
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: CHEBI:58282

metaM 34hpp e
has only substance units: false
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
name: 3-(4-hydroxyphenyl)pyruvate
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:36242
type: Species
initial concentration: 1.0
is: HMDB00707

http://identifiers.org/biomodels.db/MODEL1310110060#_1b5483c3_0bd4_4c68_b5e3_78899163b461
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: Q8N142
is encoded by: hsa:122622
is: SBO:0000252
initial amount: NaN
name: ADSSL1

W3 CDTF: Fri Aug 31 01:17:36 BST 2012

metaM bilirub c
name: bilirubin(2-)
is: CHEBI:57977
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
constant: false
has only substance units: false

metaM 10fthf m
name: 10-formyltetrahydrofolate(2-)
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
is: CHEBI:57454
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00972

metaM 3hmp m
is: HMDB00023
has only substance units: false
is: CHEBI:11805
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_1d35d012_ba5c_4d6d_90c9_90f89b0e77e8
is: E9PH29
is: SBO:0000252
is encoded by: hsa:10935
has only substance units: false
name: PRDX3
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaR r1671
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000185
type: Reaction
product: MODEL1310110060#

metaR r1569
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_345ed2a1_be69_4a70_8cee_45bf389a17e8
constant: false
is encoded by: hsa:221
initial concentration: NaN
is: SBO:0000252
name: ALDH3B1
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: P43353

metaM pyr c
is: SBO:0000247
name: pyruvate
is: CHEBI:15361
initial amount: NaN
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1
is: http://identifiers.org/pubchem.compound/3324
constant: false
boundary condition: false
is: C00022
has only substance units: false
initial concentration: 1.0
is: HMDB00243

metaM 3mop c
type: Species
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00491
initial amount: NaN
initial concentration: 1.0

metaM aicar e
is: C04677
constant: false
has only substance units: false
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01517

http://identifiers.org/biomodels.db/MODEL1310110060#_10fe6788_d690_4a13_a9b7_1a074a4a3db6
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9BVK2
type: Species
initial amount: NaN
is encoded by: hsa:79053
name: ALG8

metaR OAADC
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

metaM 2hb e
is: HMDB00008
name: 2-Hydroxybutyrate
is: CHEBI:1148
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM leuktrD4 c
is: HMDB03080
initial amount: NaN
is: CHEBI:28666
boundary condition: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
type: Species
is: SBO:0000247
name: Leukotriene D4
initial concentration: 1.0
has only substance units: false

W3 CDTF: Fri Aug 31 01:17:37 BST 2012

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR S6TASE26ly
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
reversible: true
fast: false

metaM HC01434 m
constant: false
boundary condition: false
name: oxalatosuccinate(3-)
is: CHEBI:58931
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_260637d8_5207_4cf4_ba7a_38478ef12480
is encoded by: hsa:4719
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: NDUFS1
is: P28331
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR RE3566C
reversible: true
name: RE3566
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaM 5htrp c
initial amount: NaN
is: CHEBI:17780
name: 5-hydroxy-L-tryptophan
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00472
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643

metaM mev R c
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00227
is: CHEBI:36464
boundary condition: false
has only substance units: false
constant: false
name: (R)-mevalonate

http://identifiers.org/biomodels.db/MODEL1310110060#_d1d66a74_33b9_4f7e_b8d4_923acbc05d97
has only substance units: false
name: SLC35B2
is encoded by: hsa:347734
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: Q8TB61
initial concentration: NaN

metaM ksi deg27 l
type: Species
initial amount: NaN
is: CHEBI:12936
has only substance units: false
is: HMDB00143
is: SBO:0000247
name: keratan sulfate I, degradation product 27
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
boundary condition: false
initial concentration: 1.0
constant: false

metaR ASNtN1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
name: Asparagine transport (Na, H coupled)
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#

metaM arachdcoa c
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
is: HMDB06523
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
name: arachidonoyl-CoA(4-)

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM retinol cis 11 c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
boundary condition: false
name: 11-cis-retinol
constant: false
initial amount: NaN
is: HMDB06216
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16302

metaR HS1ly
reversible: false
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000000
name: heparan-N-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.10.1.1
fast: false

metaR r1566
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: true

metaM pmtcoa x
is: C00154
is: HMDB01338
is: CHEBI:57379
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

metaM pnto R e
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB00210
has only substance units: false
is: SBO:0000247
name: (R)-Pantothenate

metaM h g
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:24636
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaM fadh2 c
initial concentration: 1.0
is: HMDB01197
boundary condition: false
initial amount: NaN
name: FADH2(2-)
constant: false
is: CHEBI:58307
has only substance units: false
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_6793eaa0_36f0_420e_b5a0_d93d25ae5a5e
type: Species
is encoded by: hsa:8654
name: PDE5A
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O76074

metaR RDH1a
product: MODEL1310110060#
is described by: ECO:0000269
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110060#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.105
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
type: Reaction
name: retinol dehydrogenase (all-trans,NADPH)

metaM na1 c
is: C01330
is: SBO:0000247
type: Species
name: Sodium
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
constant: false
is: CHEBI:4541
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a74044bd_d742_40bb_b3a7_cdd6d897a8a6
type: Species
boundary condition: true
initial amount: NaN
name: FTCD
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10841
constant: false
is: O95954

http://identifiers.org/biomodels.db/MODEL1310110060#_c5637efe_408a_4d5c_83db_a90c54ca940f
type: Species
is: Q16878
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: CDO1
is encoded by: hsa:1036
is: SBO:0000252
boundary condition: true

metaR CORE2GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110060#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_75321f3f_a8c6_4e10_a441_73fdfe3b556a
is encoded by: hsa:200010
type: Species
is: E9PAK4
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: SLC5A9
has only substance units: false
is: SBO:0000252

W3 CDTF: Fri Aug 31 01:17:37 BST 2012

metaM bilirub e
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
is: HMDB00054
name: bilirubin(2-)

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaM na1 e
has only substance units: false
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: Sodium
is: CHEBI:4541
initial concentration: 1.0
is: C01330

metaR RETFA
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000176
name: retinol acyltransferase
reversible: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
product: MODEL1310110060#

metaM glx x
is: CHEBI:36655
name: glyoxylate
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
type: Species
is: HMDB00119
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6b30f686_35d2_41b6_b12d_9bf00034d834
name: PRDX2
is encoded by: hsa:7001
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR OCDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000185

metaM gmp g
has only substance units: false
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
is: SBO:0000247
name: GMP(3-)
is: CHEBI:58115
is: HMDB01397
initial amount: NaN
constant: false
initial concentration: 1.0

metaR GULLACter
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: gulonolactone endoplasmic reticular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#

metaM cit e
name: citrate(3-)
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
boundary condition: false
is: CHEBI:16947
is: HMDB00094
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_d7d21195_d382_4714_b289_71d380bbf9fa
initial concentration: NaN
is encoded by: hsa:3425
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: IDUA
type: Species
is: SBO:0000252
is: P35475

metaR 2HBt2
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
name: 2-hydroxybutyrate cotransport with proton
type: Reaction
modifier: MODEL1310110060#
is: SBO:0000185
reversible: true
reactant: MODEL1310110060#
is described by: ECO:0000269

metaR THRGLNexR
type: Reaction
name: L-threonine/glycine reversible exchange
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110060#
reactant: MODEL1310110060#

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaM pyr e
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species
name: pyruvate
constant: false
boundary condition: false
is: HMDB00243
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:15361
initial amount: NaN

metaR DAGK hs
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110060#
fast: false
product: MODEL1310110060#
name: Diacylglycerol phosphate kinase (homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.1.107
is described by: ECO:0000269
reactant: MODEL1310110060#
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110060#

metaM o2 n
initial amount: NaN
constant: false
is: CHEBI:15379
name: dioxygen
is: HMDB01377
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR r1567
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SUCRe
name: sucrose hydrolyzing enxyme, extracellular
is version of: http://identifiers.org/ec-code/3.2.1.10
fast: false
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
type: Reaction
product: MODEL1310110060#
reversible: false
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.20

metaM 2mop m
initial concentration: 1.0
is: HMDB01172
has only substance units: false
boundary condition: false
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: CHEBI:57700
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_35c4100e_0c89_418d_8612_8fdde335ce28
name: PKLR
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:5313
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is: P30613

http://identifiers.org/biomodels.db/MODEL1310110060#_88b9d298_2885_4d2b_a8bf_c205f1a301d8
has only substance units: false
initial amount: NaN
name: ALDH3B2
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: P48448
is encoded by: hsa:222
boundary condition: true

metaM h m
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
initial concentration: 1.0
is: CHEBI:24636
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: C00080
name: proton

http://identifiers.org/biomodels.db/MODEL1310110060#_c1b1f47f_d16a_4a99_8b84_32408e640ae1
is: P13995
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10797
name: MTHFD2
constant: false
type: Species
initial concentration: NaN

metaR FRDPtc
is: SBO:0000185
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reversible: true
reactant: MODEL1310110060#
fast: false
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_3f20cf47_bd41_4719_bddf_07546e8251e1
initial amount: NaN
constant: false
name: FUT8
boundary condition: true
is encoded by: hsa:2530
is: SBO:0000252
initial concentration: NaN
is: Q546E0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_428ad601_984f_40a1_b5e5_ab5e9ca90520
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: ACADS
is: P16219
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:35

metaR CHSTEROLt1
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000304
name: cholesterol intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110060#_0a4d3f8f_b6c3_4928_b25b_bf35f02e7c80
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q96AT9
is encoded by: hsa:6120
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: RPE

http://identifiers.org/biomodels.db/MODEL1310110060#_c80d2fc8_c29e_4e2a_b095_4920e56800e6
has part: Q86TM7
has only substance units: false
name: DPM3:DPM1:DPM2
is encoded by: hsa:8818
has part: O94777
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
boundary condition: true
has part: O60762
is encoded by: hsa:8813
type: Species
is encoded by: hsa:54344
constant: false

metaR FALDH
is described by: ECO:0000269
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
reversible: true
modifier: MODEL1310110060#
name: formaldehyde dehydrogenase
is: SBO:0000176
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_47d199df_1c82_45cb_aec0_d69161888fd2
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6520
name: SLC7A10:SLC3A2
constant: false
has part: Q9NS82
is encoded by: hsa:56301
is: SBO:0000297
has part: P08195

metaM pmtcoa r
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: C00154
is: SBO:0000247
is: CHEBI:3454
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01338
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)

metaR ACOAD10m
modifier: MODEL1310110060#
is described by: ECO:0000269
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
reversible: false
is: SBO:0000176
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110060#_b04c322f_d231_401e_a22c_500c9f2037ec
has only substance units: false
type: Species
is encoded by: hsa:2539
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is: P11413
name: G6PD

metaR RE2660N
fast: false
reactant: MODEL1310110060#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is: SBO:0000176
product: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE2660
kinetic law: MODEL1310110060#

metaR r1564
is described by: ECO:0000000
product: MODEL1310110060#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_d9568a18_7bdc_4b13_9040_f9470f29abde
initial amount: NaN
is encoded by: hsa:55753
boundary condition: true
is: Q9ULD0
constant: false
initial concentration: NaN
name: OGDHL
has only substance units: false
is: SBO:0000252
type: Species

metaM clpn hs c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CHARGE: 0
constant: false
is: SBO:0000247
type: Species
is: HMDB02704
initial amount: NaN
has only substance units: false
name: clpn_hs[c]
is: CHEBI:21338

metaM CE0849 m
name: cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57795

metaM Rtotal3coa c
name: R total 3 Coenzyme A
is: CHEBI:16189
is: HMDB01448
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM ksii core2 deg5 l
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: CHEBI:12936
has only substance units: false
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 5
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_cee868ce_43eb_4995_a822_1ba0c388e4ec
constant: false
name: MPO
boundary condition: true
is: P05164
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4353

metaM h l
initial concentration: 1.0
has only substance units: false
is: C00080
boundary condition: false
is: SBO:0000247
type: Species
name: proton
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
is: CHEBI:24636

metaM ksi deg28 l
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57455
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
boundary condition: false
is: HMDB01354
name: keratan sulfate I, degradation product 28

metaM xyl D c
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15936
name: aldehydo-D-xylose

metaR GALASE6ly
product: MODEL1310110060#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110060#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.23

http://identifiers.org/biomodels.db/MODEL1310110060#_b3e58170_80f2_47e2_8d4c_3cd2986d4c7c
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:51205
is: Q9NPH0
initial concentration: NaN
has only substance units: false
type: Species
name: ACP6

metaM dcmp n
type: Species
name: dCMP(2-)
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
constant: false
is: CHEBI:57566
boundary condition: false
initial concentration: 1.0

metaR BILIRUBt2
name: bilirubin transport via bicarbonate countertransport
reversible: true
reactant: MODEL1310110060#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_4a28195c_02fd_4b20_9ecc_fad71b0be560
boundary condition: true
type: Species
has only substance units: false
name: PLCB1
is: Q9NQ66
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:23236
initial concentration: NaN

metaM ksi deg30 l
has only substance units: false
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
name: keratan sulfate I, degradation product 30
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:12936
type: Species
boundary condition: false

metaR KSItly
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: false
fast: false
name: keratan sulfate I transport, extracellular to lysosome
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110060#_3f7abc80_fb7c_41ea_a823_f9297d2cd3a8
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8818
type: Species
has only substance units: false
constant: false
boundary condition: true
name: DPM2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_d3566363_a0f9_4070_b2ca_3d465ede2800
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: _AI934540_1_c
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AI934540

metaR r1565
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR S6T3g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
product: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110060#
is: SBO:0000176
fast: false

metaM h2o2 l
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
name: hydrogen peroxide
is: SBO:0000247
is: CHEBI:16240
type: Species
boundary condition: false
is: HMDB03125

http://identifiers.org/biomodels.db/MODEL1310110060#_9dcb7285_08ce_47ef_b035_13411f823f2f
is: P15531
type: Species
is: SBO:0000252
name: NME1
is encoded by: hsa:4830
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM glyc3p c
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:57597
constant: false
is: HMDB00126
name: Glycerol 3-phosphate
initial concentration: 1.0
boundary condition: false

metaR S6T18g
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.8.2.21
is version of: http://identifiers.org/ec-code/2.8.2.17
type: Reaction
fast: false
reversible: false
product: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110060#_71b5575c_e748_47a0_a7e4_5f226d362387
is: SBO:0000252
initial amount: NaN
constant: false
is: Q6P1K9
initial concentration: NaN
is encoded by: hsa:80025
name: PANK2
boundary condition: true
type: Species
has only substance units: false

metaR G14Tg
is: SBO:0000176
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000269
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reversible: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false

metaR CHSTEROLt3
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
name: cholesterol intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110060#_33861c07_3b93_4ec0_989a_52c89045e882
type: Species
is encoded by: hsa:728441
constant: false
has only substance units: false
boundary condition: true
name: GGT2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM retinol 9 cis c
constant: false
initial concentration: 1.0
has only substance units: false
name: 9-cis-retinol
boundary condition: false
is: HMDB06217
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
type: Species
is: CHEBI:17336

metaR r1988
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110060#

metaM chol e
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15354
is: HMDB00097
has only substance units: false
constant: false
name: Choline
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_2fe8f0ef_2397_42ed_8991_8cf0a9a8a758
is: Q14117
is encoded by: hsa:1807
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: DPYS

http://identifiers.org/biomodels.db/MODEL1310110060#_2296cc78_6075_49e0_8295_4e526d0ddb5a
is encoded by: hsa:8534
constant: false
is: SBO:0000252
is: O43916
boundary condition: true
name: CHST1
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaM HC01609 e
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: UroporphyrinogenI
type: Species
is: CHEBI:28766
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766

http://identifiers.org/biomodels.db/MODEL1310110060#_8816cc90_d266_4cb0_bef5_4dd771bc014d
name: CCBL1
is: SBO:0000252
constant: false
is encoded by: hsa:883
is: Q16773
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaM thbpt4acam n
constant: false
is: SBO:0000247
is: HMDB02281
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: 4a-hydroxytetrahydrobiopterin
is: CHEBI:15374
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_02a9239b_1185_4e01_8462_6d16a5c01e95
type: Species
is encoded by: hsa:374291
initial amount: NaN
name: NDUFS7
boundary condition: true
initial concentration: NaN
is: O75251
constant: false
is: SBO:0000252
has only substance units: false

metaR GALASE14ly
type: Reaction
reversible: false
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaM HC02193 e
is: SBO:0000247
name: glycolithocholate
is: CHEBI:60008
type: Species
constant: false
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

metaM ksii core2 pre2 g
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 2
boundary condition: false
has only substance units: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: HMDB00175
initial amount: NaN
is: C00130

metaR r1562
kinetic law: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_d517f988_5c5b_418b_a424_bca03712569f
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6389
initial amount: NaN
type: Species
boundary condition: true
is: P31040
name: SDHA

metaM h2o2 m
constant: false
has only substance units: false
name: Hydrogen peroxide
boundary condition: false
is: HMDB03125
is: SBO:0000247
is: CHEBI:16240
type: Species
initial concentration: 1.0
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN

metaM methf m
initial concentration: 1.0
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01354
name: (6R)-5,10-methenyltetrahydrofolate
is: CHEBI:57455

http://identifiers.org/biomodels.db/MODEL1310110060#_3015a51d_fa70_40cd_96de_ce1ae13d534f
is: SBO:0000252
has only substance units: false
type: Species
is: Q9HC21
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:60386
boundary condition: true
name: SLC25A19
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_4259c350_c7a9_4cbc_8fa5_1b4b9f1a93cc
has only substance units: false
is encoded by: hsa:4697
name: NDUFA4
boundary condition: true
type: Species
is: O00483
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM xyl D e
name: aldehydo-D-xylose
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:15936
boundary condition: false

metaR CHSTEROLt2
reactant: MODEL1310110060#
is described by: ECO:0000000
name: cholesterol intracellular transport
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
product: MODEL1310110060#

metaM chsterol c
initial concentration: 1.0
name: cholesterol
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
has only substance units: false
is: CHEBI:16113
constant: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR r0584
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
reversible: true

metaM biliverd c
is: CHEBI:57991
boundary condition: false
constant: false
name: biliverdin(2-)
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01008
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_7407a930_fbc3_4be6_ade0_bc7bf157be6a
boundary condition: true
name: DPM3:DPM1:DPM2
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:8818
is: SBO:0000297
is encoded by: hsa:54344
has part: Q9P2X0
has only substance units: false
initial concentration: NaN

metaR r1677
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#

metaM aicar c
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: C04677
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58475
is: HMDB01517
type: Species
initial amount: NaN

metaM 3mop e
is: CHEBI:28654
initial concentration: 1.0
constant: false
name: 3-methyl-2-oxopentanoate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: HMDB00491
has only substance units: false
boundary condition: false
type: Species

metaR GALASE20ly
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM acetol c
initial amount: NaN
constant: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
boundary condition: false
has only substance units: false
is: HMDB06961
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27957
name: hydroxyacetone
type: Species

metaM o2 r
initial concentration: 1.0
is: HMDB01377
has only substance units: false
name: O2
constant: false
initial amount: NaN
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: CHEBI:15379
type: Species
is: SBO:0000247

metaR GCCcm
product: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoylprotein), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#

metaM hs deg5 l
is: HMDB00158
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: heparan sulfate, degradation product 5
boundary condition: false
initial concentration: 1.0
is: CHEBI:17895
type: Species
notes: FORMULA: C67H97N4O86S10 CHARGE: -11

http://identifiers.org/biomodels.db/MODEL1310110060#_3bfcc756_ea67_4bb8_a5aa_44c652c34aba
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: _H77542_1_c
is: SBO:0000252
is encoded by: hsa:H77542

metaR r1563
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_2c9831df_4807_46d0_9bee_703568b8bcde
name: NDUFB1
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:4707
is: O75438

metaM g3p c
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
constant: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3930
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB01112
is: C00661
name: Glyceraldehyde 3-phosphate
type: Species
is: CHEBI:58027

metaM fadh2 m
has only substance units: false
is: SBO:0000247
is: HMDB01197
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
constant: false
is: CHEBI:58307
initial concentration: 1.0
type: Species
is: C01352
name: Flavin adenine dinucleotide reduced
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_c94a473e_4ed5_4e85_b7b6_64f062b48265
is encoded by: hsa:AA419122
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: _AA419122_1_c
is: SBO:0000252
has only substance units: false

metaR r2344
reversible: true
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM leu L m
name: L-leucine
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
is: CHEBI:15603
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR NODe
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
type: Reaction
name: NODe
is described by: ECO:0000134

metaR r0474
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: true
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#

metaR DCK2n
reactant: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (UTP)
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is: SBO:0000176

metaM arachdcoa m
is: CHEBI:57368
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
constant: false
name: arachidonoyl-CoA(4-)
has only substance units: false
boundary condition: false

metaR H2O2tly
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#
is: SBO:0000185
name: hydrogen peroxide lysosomal transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110060#_b40375a0_becb_4826_bd5f_a61f228b8666
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:23563
initial amount: NaN
name: CHST5

metaR RE0926E
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110060#
reactant: MODEL1310110060#
name: RE0926
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_8188cf92_7a44_48af_b5c0_270323d76f3f
constant: false
has only substance units: false
is: P50747
is encoded by: hsa:3141
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: HLCS
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_0b467a02_d204_490b_8bea_7050b6f3aab4
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _H45672_1_m
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:H45672

http://identifiers.org/biomodels.db/MODEL1310110060#_0bc4c043_2d97_46bf_9bd9_c55324108158
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:278
initial amount: NaN
boundary condition: true
name: AMY1C
constant: false
is: P04745

metaR CORE4GTg
is: SBO:0000176
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.102
product: MODEL1310110060#
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
modifier: MODEL1310110060#
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000254
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.5.4.9

metaR ASCBOX
name: ascorbic acid oxidase
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_fe50ee93_3197_4267_b5e8_f97335f3faf7
is encoded by: hsa:4830
type: Species
initial concentration: NaN
name: NME1
boundary condition: true
initial amount: NaN
is: P15531
constant: false
is: SBO:0000252
has only substance units: false

metaM 3snpyr c
constant: false
has only substance units: false
is: SBO:0000247
name: 3-Sulfinopyruvate
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:1665
initial concentration: 1.0
is: HMDB02332

metaR AG13T7g
modifier: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is: SBO:0000176

metaR TYRt
name: L-tyrosine transport
product: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
is described by: ECO:0000269
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_ff629593_41b9_42d8_a6fb_86ebc0c8323c
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: P43353
name: ALDH3B1
boundary condition: true
is encoded by: hsa:221

metaM leuktrA4 e
is: HMDB01337
has only substance units: false
is: CHEBI:57463
name: leukotriene A4(1-)
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaM h2o2 x
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: SBO:0000247
initial amount: NaN
is: CHEBI:16240
constant: false
name: Hydrogen peroxide
type: Species

metaM HC00250 c
is: SBO:0000247
has only substance units: false
boundary condition: false
name: hydrosulfide
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:29919

metaR ME1m
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.38
is: SBO:0000176
modifier: MODEL1310110060#
reversible: false
name: malic enzyme (NAD), mitochondrial
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaR RE2660C
type: Reaction
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true

metaM Lcystin c
has only substance units: false
is: CHEBI:16283
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: L-cystine
constant: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_ffd5f488_6faf_4122_aed4_bae7c130f4cd
is encoded by: hsa:7355
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC35A2
type: Species
is: P78381
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_0ee37032_c227_47c8_8486_e44ab87027b7
has only substance units: false
initial amount: NaN
name: PDE5A
constant: false
is encoded by: hsa:8654
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaM ficytC m
constant: false
is: CHEBI:15991
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Ferricytochrome c
type: Species
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_58492e92_9fe5_44fc_85f9_2d88b9345a6d
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5091
constant: false
name: PC
has only substance units: false

metaM 10fthf e
is: HMDB00972
has only substance units: false
initial amount: NaN
is: CHEBI:57454
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
type: Species
initial concentration: 1.0

metaM HC01434 x
boundary condition: false
has only substance units: false
is: CHEBI:58931
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_38f24450_9875_452e_a21c_5c597adcb484
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:5315
boundary condition: true
is: SBO:0000252
is: P14618
initial concentration: NaN
name: PKM2

http://identifiers.org/biomodels.db/MODEL1310110060#_9fc62123_da33_40df_8b54_fcd003e2816a
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P00441
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6647
constant: false
name: SOD1

metaR r1453
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reversible: true
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000176
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_d5319245_cc14_480c_9489_2d96d11cd941
initial amount: NaN
boundary condition: true
name: DPYSL2
type: Species
is encoded by: hsa:1808
is: SBO:0000252
has only substance units: false
is: B4DR31
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_d5cd55e2_6db4_4663_a108_3db46a5eadd9
constant: false
is: SBO:0000252
is: P06737
boundary condition: true
is encoded by: hsa:5836
has only substance units: false
name: PYGL
type: Species
initial concentration: NaN
initial amount: NaN

metaM man c
is: CHEBI:16024
initial amount: NaN
name: D-Mannose
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
is: HMDB00169
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

metaM gdp g
is: HMDB01201
initial concentration: 1.0
initial amount: NaN
type: Species
name: GDP(3-)
is: CHEBI:58189
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
constant: false
is: SBO:0000247

metaR r0267
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.5.1.9
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:

metaM dmnoncrn c
initial concentration: 1.0
notes: FORMULA: C18H37NO4 CHARGE: 0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: HMDB06202
initial amount: NaN
has only substance units: false
name: 4,8-dimethylnonanoyl carnitine

metaM CE2435 m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: trans,cis-deca-2,4-dienoyl-CoA
is: CHEBI:57795

metaR S6TASE10ly
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r2346
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110060#_ad40cd97_e8aa_4471_8d96_bd3cc419c58c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: Q5QPH3
name: ACSS2
constant: false
has only substance units: false
is encoded by: hsa:55902

http://identifiers.org/biomodels.db/MODEL1310110060#_e6ec29e9_ace5_4130_92a0_2becdd81de5d
is: SBO:0000252
is encoded by: hsa:43
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ACHE
constant: false

metaM dhap x
initial concentration: 1.0
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3411
is: HMDB01473
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57642
name: Dihydroxyacetone phosphate
is: C00111
is: SBO:0000247

metaR RE1521M
is: SBO:0000176
type: Reaction
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
name: RE1521
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_2cb14e46_bc61_4f8d_ba89_bfe2d3a73e62
is encoded by: hsa:4720
is: B7Z792
boundary condition: true
type: Species
name: NDUFS2
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_c975dfc8_4901_4557_94f7_23b995071741
is: Q6PCB7
name: SLC27A1
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:376497

metaR GLYt7 211 r
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
is described by: ECO:0000269
name: glycine reversible transport via sodium and chloride symport (2:1:1)
type: Reaction
modifier: MODEL1310110060#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_0bf10416_7bd7_4be7_aa03_9416a325ef75
has only substance units: false
boundary condition: true
is: Q9NRA2
type: Species
name: SLC17A5
initial concentration: NaN
is encoded by: hsa:26503
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_4bb00374_bcb0_4aba_80a9_d9fe01cf6e1d
name: _D87002_1_m
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:D87002
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaR PVD3
product: MODEL1310110060#
name: Previtamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is described by: ECO:0000134
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
fast: false
is: SBO:0000176
reversible: true

metaR r1454
product: MODEL1310110060#
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000185
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110060#

metaR SADT
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
name: sulfate adenylyltransferase
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.1.25
product: MODEL1310110060#

metaR FAOXC160
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110060#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110060#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM cit m
has only substance units: false
constant: false
is: SBO:0000247
name: Citrate
initial amount: NaN
is: HMDB00094
type: Species
is: C00158
is: CHEBI:16947
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0

metaM m3mpdol U c
is: CHEBI:37632
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
initial amount: NaN
boundary condition: false

metaR GLCNACASE5ly
fast: false
type: Reaction
product: MODEL1310110060#
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
modifier: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false

metaR r0268
reactant: MODEL1310110060#
is described by: ECO:0000000
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is: SBO:0000176
reversible: true
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.3.2
is version of: http://identifiers.org/ec-code/3.1.3.1

metaR NTD7
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110060#
reversible: false
product: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
name: 5'-nucleotidase (AMP)

metaR r0475
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaM 3hpcoa m
initial concentration: 1.0
is: SBO:0000247
name: 3-hydroxypropanoyl-CoA(4-)
boundary condition: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:58528

metaR r2347
is: SBO:0000185
fast: false
product: MODEL1310110060#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_aed54485_760e_461b_ab28_63f66bb8a6bd
boundary condition: true
name: LDHD
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:197257
has only substance units: false
constant: false

metaM adprbp e
has only substance units: false
boundary condition: false
name: ADP-D-ribose 2'-phosphate(4-)
is: HMDB06336
notes: FORMULA: C15H20N5O17P3 CHARGE: -4 INCHI: InChI=1S/C15H24N5O17P3/c16-12-7-13(18-3-17-12)20(4-19-7)14-11(35-38(25,26)27)9(23)6(33-14)2-32-39(28,29)37-40(30,31)36-15-10(24)8(22)5(1-21)34-15/h3-6,8-11,14-15,21-24H,1-2H2,(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/p-4/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C03246
is: CHEBI:58673
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR EX adprib LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose exchange
type: Reaction

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaM 10fthf c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
is: HMDB00972
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: C00234
initial concentration: 1.0
has only substance units: false
type: Species

metaR 34DHPLACOX
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
is: SBO:0000176
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
product: MODEL1310110060#
type: Reaction
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000269

metaM gdpmann c
boundary condition: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57527
name: GDP-alpha-D-mannose(2-)
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01163

metaR r1459
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110060#
name: Transport reaction
type: Reaction
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: true

metaR RE0383C
type: Reaction
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
name: RE0383

metaM HC01405 m
is: SBO:0000247
has only substance units: false
constant: false
name: (S)-Hydroxyoctanoyl-CoA
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
boundary condition: false
initial concentration: 1.0
is: CHEBI:28632
initial amount: NaN
type: Species

metaR PMTCOAtx
is described by: ECO:0000000
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110060#
fast: false
type: Reaction
reactant: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_e82ac90c_29a4_48fd_a1fc_84e52dfc621f
initial concentration: NaN
is: SBO:0000252
is: G3XA95
name: PPAP2A
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8611

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_6c9f4c09_f710_4b10_97bc_d9c4e3b1efb5
is encoded by: hsa:55577
name: NAGK
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9UJ70
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaM pnto R c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916
is: HMDB00210
constant: false
is: SBO:0000247
name: (R)-Pantothenate
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_0bdf630d_f1ad_43f7_b56b_cea949c44202
is: SBO:0000252
initial concentration: NaN
name: NDUFA4
is: O00483
has only substance units: false
is encoded by: hsa:4697
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaM h e
type: Species
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: SBO:0000247
constant: false
name: proton
is: CHEBI:24636
has only substance units: false
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "

http://identifiers.org/biomodels.db/MODEL1310110060#_803e3f42_c5a7_408b_9cd3_b8c89e1804ed
initial amount: NaN
is: Q6IBE6
is encoded by: hsa:6484
boundary condition: true
constant: false
name: ST3GAL4
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM xyl D l
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:15936
has only substance units: false
constant: false

metaR CMPACNAtg
reversible: true
name: CMP-Sia Golgi transport via CMP antiport
fast: false
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110060#
modifier: MODEL1310110060#

metaR PHEMEt
reactant: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
kinetic law: MODEL1310110060#
is described by: ECO:0000269
name: heme transport
product: MODEL1310110060#
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110060#

metaR 4NPHSFte
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
reversible: true
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
name: xenobiotic transport
fast: false

metaM leuktrD4 e
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
is: HMDB03080
constant: false
type: Species
initial amount: NaN
is: CHEBI:28666
has only substance units: false
name: Leukotriene D4
is: SBO:0000247
boundary condition: false

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaM thbpt4acam c
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:15374
boundary condition: false
initial concentration: 1.0
is: HMDB02281
constant: false
has only substance units: false

metaR UGALNACtg
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
product: MODEL1310110060#
name: UDP-GalNAc Golgi transport via CMP antiport
type: Reaction
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaR RE3346C
name: RE3346
reactant: MODEL1310110060#
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110060#

metaR G14T8g
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
modifier: MODEL1310110060#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR PI45PLC
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reactant: MODEL1310110060#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false
reversible: false
modifier: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11

http://identifiers.org/biomodels.db/MODEL1310110060#_94acd89d_7a1d_44d6_bae2_50d3e035b6fc
name: _AI348006_1_c
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI348006
has only substance units: false
type: Species

metaM prostgh2 c
is: SBO:0000247
is: CHEBI:57405
name: prostaglandin H2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
is: HMDB01381

metaR r2341
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110060#

metaM paf hs e
type: Species
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: CHEBI:36707
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: 1-alkyl 2-acteylglycerol 3-phosphocholine

metaM o2 x
is: CHEBI:15379
is: HMDB01377
type: Species
has only substance units: false
name: O2
boundary condition: false
initial amount: NaN
is: C00007
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a9caf641_8411_4c28_a1b8_f6ada33d4687
initial concentration: NaN
is: P36957
initial amount: NaN
name: DLST
has only substance units: false
constant: false
is encoded by: hsa:1743
is: SBO:0000252
type: Species
boundary condition: true

metaR LTC4CP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110060#
name: Leukotriene C4 carboxypeptidase
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_b21e4158_9673_49d4_b03f_c70efde901cf
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: PLCL1
is encoded by: hsa:5334
is: Q15111
has only substance units: false
boundary condition: true
type: Species

metaR THRD L
is version of: http://identifiers.org/ec-code/4.3.1.17
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: L-threonine deaminase
reversible: false
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
type: Reaction
is described by: ECO:0000269
fast: false

metaR LEUKTRD4t
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
name: leukotriene D4 transport
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false

metaM chol n
constant: false
name: choline
is: HMDB00097
has only substance units: false
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_3095be5d_2d8e_4d14_8eee_42cb679c8742
constant: false
name: PDE3B
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: A7E2E5
is: SBO:0000252
type: Species
is encoded by: hsa:5140
boundary condition: true

metaR DIGALSIDEtg
reactant: MODEL1310110060#
type: Reaction
name: digalside hs intracellular transport
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#

metaR AG13T11g
kinetic law: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false

metaR DCYTDn
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
fast: false
kinetic law: MODEL1310110060#
name: deoxycytidine deaminase, nuclear
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110060#
is described by: ECO:0000254
product: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_68d2c50f_4fc4_4a3b_be8c_3db9f905f995
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2720
constant: false
name: GLB1
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P16278

metaM gdp c
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
is: CHEBI:58189
name: GDP
is: HMDB01201
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: C00035

metaM h c
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: C00080
is: SBO:0000247
is: CHEBI:24636
constant: false
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "

http://identifiers.org/biomodels.db/MODEL1310110060#_652c4acd_c16e_47dc_be6c_fcf39b62bb0a
initial amount: NaN
name: NDUFA2
constant: false
initial concentration: NaN
is encoded by: hsa:4695
is: SBO:0000252
is: O43678
type: Species
boundary condition: true
has only substance units: false

metaR SERDGLYexR
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000304
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110060#
name: D-Serine/Glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110060#
type: Reaction

metaM C05965 e
has only substance units: false
name: 12(S)-HPETE(1-)
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57444
initial amount: NaN
initial concentration: 1.0
is: HMDB04243
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965

http://identifiers.org/biomodels.db/MODEL1310110060#_c3af7070_2056_4b3a_9351_10b007b87ad7
constant: false
name: ADH1B
is: SBO:0000252
is encoded by: hsa:125
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: P00325

metaM methf c
is: HMDB01354
type: Species
is: C00445
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
has only substance units: false
name: 5,10-Methenyltetrahydrofolate
is: CHEBI:57455

http://identifiers.org/biomodels.db/MODEL1310110060#_eb1ced21_fd8e_4ff4_8d0e_c225e0797816
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2650
initial concentration: NaN
name: GCNT1
is: Q02742

http://identifiers.org/biomodels.db/MODEL1310110060#_e85edb4b_c7b7_4c48_b320_2feeeb5858ec
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:C7orf24
initial concentration: NaN
has only substance units: false
type: Species
name: _C7orf24_1_m
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_34c1f897_c76e_4d05_81cc_727ff85aba57
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: CA12
is encoded by: hsa:771

metaM mi1345p c
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
initial concentration: 1.0
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial amount: NaN
is: CHEBI:57895
is: SBO:0000247
type: Species
constant: false
has only substance units: false
boundary condition: false
is: HMDB01059

metaR EX 34hpp
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_382c3a3b_fbd9_4ea4_bcec_e1aae7f1e9f8
type: Species
name: IMPA1
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: B7Z6Q4
initial concentration: NaN
is encoded by: hsa:3612
constant: false

metaM l2fn2m2masn g
initial concentration: 1.0
has only substance units: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: CHEBI:28067
type: Species
constant: false
boundary condition: false
notes: FORMULA: C68H113N4O49X CHARGE: 0
is: SBO:0000247
initial amount: NaN

metaM arachcrn m
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
name: arachidyl carnitine
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: HMDB06460
initial concentration: 1.0
boundary condition: false
constant: false

metaM dcmp c
type: Species
name: dCMP
has only substance units: false
initial amount: NaN
is: HMDB01202
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
is: C00239
constant: false
is: SBO:0000247
is: CHEBI:57566

http://identifiers.org/biomodels.db/MODEL1310110060#_c8d00054_c66f_456e_a404_bb8594d27f20
has only substance units: false
name: PKLR
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5313
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_4244f202_4ad0_4414_9799_d409c13aa509
type: Species
name: SLC6A5
constant: false
has only substance units: false
is encoded by: hsa:9152
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9Y345
boundary condition: true

metaM chol m
name: choline
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
is: HMDB00097
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_538bf327_4810_4e7c_88a4_237d9a01abab
has only substance units: false
name: ADHFE1
is encoded by: hsa:137872
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: Q8IWW8
type: Species

metaM HC00250 e
name: hydrosulfide
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
has only substance units: false
constant: false
boundary condition: false

metaR NDPK2n
fast: false
is: SBO:0000176
kinetic law: MODEL1310110060#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_3e5205ba_40a2_4942_9c84_845875e6931a
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:622
constant: false
initial amount: NaN
has only substance units: false
name: BDH1

http://identifiers.org/biomodels.db/MODEL1310110060#_6d45839a_3f3d_45f8_a583_f94767d6c2ab
type: Species
is encoded by: hsa:2592
boundary condition: true
name: GALT
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: B2RAT6

http://identifiers.org/biomodels.db/MODEL1310110060#_ee1dc051_08a2_42c7_90c1_82e85c13834f
initial amount: NaN
has part: Q5VYT2
boundary condition: true
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000297
is encoded by: hsa:4712
is encoded by: hsa:4731
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_e597974c_5ffb_489f_a789_725c5d61ba60
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is: Q9HBF5
name: ST20
is encoded by: hsa:400410
initial amount: NaN

metaM ksi pre7 g
is: C00130
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C115H187N8O85SX CHARGE: -2
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 7

http://identifiers.org/biomodels.db/MODEL1310110060#_ebf8566a_1753_43e9_a813_0d7276171877
initial amount: NaN
is: P42765
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10449
has only substance units: false
constant: false
name: ACAA2

metaM leuktrA4 c
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: CHEBI:57463
initial concentration: 1.0
name: leukotriene A4(1-)
is: HMDB01337
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_7fc8f136_cf76_4531_900f_2fb89cd6479b
is encoded by: hsa:54539
has only substance units: false
constant: false
boundary condition: true
is: Q9NX14
initial concentration: NaN
type: Species
is: SBO:0000252
name: NDUFB11
initial amount: NaN

metaM bilirub r
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
name: bilirubin(2-)
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57977

metaM r5p c
boundary condition: false
has only substance units: false
is: HMDB00618
is: CHEBI:18189
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
name: alpha-D-Ribose 5-phosphate
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C00117
constant: false

metaM udpglcur r
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:58052
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
name: UDP-D-glucuronate
is: SBO:0000247
is: HMDB00935
is: C00167

metaR CYSGLYexR
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
name: L-cysteine/glycine reversible exchanger
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
fast: false

metaR GCHOLAtx
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
product: MODEL1310110060#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport

metaM gmp c
is: CHEBI:58115
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: C00144
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01397
boundary condition: false
name: GMP

metaM 3sala c
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: C00606
initial amount: NaN
is: CHEBI:61085
name: 3-Sulfino-L-alanine
is: SBO:0000247
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
boundary condition: false

metaM hs deg21 l
is: SBO:0000247
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:16126
constant: false
has only substance units: false

metaM 34hpp c
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
initial amount: NaN
is: HMDB00707
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36242
boundary condition: false
constant: false

metaR EX ins LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Inosine exchange
type: Reaction

metaR EBP1r
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000134
kinetic law: MODEL1310110060#
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
is version of: http://identifiers.org/ec-code/5.3.3.5
reversible: false
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is: SBO:0000176

metaR PI4PLC
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4-phosphate phospholipase C
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
fast: false

metaR RE2649C
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reactant: MODEL1310110060#
is described by: ECO:0000000
name: RE2649
modifier: MODEL1310110060#
reversible: true

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR DOPAtu
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Dopamine uniport
is described by: ECO:0000269

metaM fe2 c
is: CHEBI:29033
is: C00023
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00692
has only substance units: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial concentration: 1.0
name: Fe2+

http://identifiers.org/biomodels.db/MODEL1310110060#_256522f6_5b22_44da_8e8f_cdb70ae61efc
initial amount: NaN
is encoded by: hsa:79695
name: GALNT12
is: Q8IXK2
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM dnad c
is: CHEBI:18304
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: Deamino-NAD+
initial amount: NaN
is: C00857
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
constant: false
is: HMDB01179
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_d3b5fd32_3889_45d3_b018_f8d65c507bb3
is: Q59FD4
constant: false
is: SBO:0000252
name: HK1
is encoded by: hsa:3098
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR CREATt4 2 r
kinetic law: MODEL1310110060#
is described by: ECO:0000269
modifier: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
name: Creatine transport (sodium symport) (2:1)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_e8c16523_1186_4471_97af_91dc6da01f2d
type: Species
name: COX7A2
is: H0UI06
is encoded by: hsa:1347
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR r0706
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is: SBO:0000176
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.10
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110060#_904a97ed_84f9_4b4c_babe_2a1e2d45fb8e
initial concentration: NaN
is encoded by: hsa:6392
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O14521
type: Species
constant: false
name: SDHD
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_32396e28_be70_4918_8cf5_6d00782e51cb
is: P35573
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: AGL
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:178

metaM 2dr5p c
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: HMDB01031
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57651
type: Species
constant: false

metaR ACHEe
fast: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
name: Acetylcholinesterase
reactant: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110060#
reversible: false
product: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.1.7

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM no e
is: SBO:0000247
is: HMDB03378
constant: false
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: C00533
name: Nitric oxide
initial concentration: 1.0

metaM gtp c
is: C00044
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: HMDB01273
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: GTP
is: CHEBI:37565

metaM meoh e
type: Species
is: CHEBI:17790
boundary condition: false
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: HMDB01875
has only substance units: false
name: methanol
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a32f46a9_3cbd_4a20_9104_97b14666e8d1
type: Species
is: Q16760
is: SBO:0000252
name: DGKD
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8527
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_d1d4393d_e06b_4377_865d_c11a0300c5d2
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: P48067
initial concentration: NaN
is encoded by: hsa:6536
is: SBO:0000252
name: SLC6A9

http://identifiers.org/biomodels.db/MODEL1310110060#_93d77704_3b24_4378_a8b6_62ac6a53ff05
name: SLC7A8
is encoded by: hsa:23428
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q86U05

http://identifiers.org/biomodels.db/MODEL1310110060#_0e247e3d_8fdb_42a2_b453_d9e9705d1d80
has only substance units: false
name: GGCT
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: B8ZZR8
boundary condition: true
is encoded by: hsa:79017

metaR r1826
is: SBO:0000185
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Y+LAT2 Utilized transport
product: MODEL1310110060#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_604fd3f3_cf71_486d_bce3_4e18100e6807
initial concentration: NaN
is: A6NDW6
constant: false
is: SBO:0000252
is encoded by: hsa:79053
initial amount: NaN
has only substance units: false
boundary condition: true
name: ALG8
type: Species

metaR 2AMADPTm
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
product: MODEL1310110060#
fast: false
is described by: ECO:0000269
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
is: SBO:0000185
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaM na1 r
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
type: Species
has only substance units: false
name: sodium(1+)
is: HMDB00588
boundary condition: false
constant: false
is: CHEBI:29101

metaM HC00319 m
boundary condition: false
is: CHEBI:30794
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
constant: false
name: Malonate
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_dbe0a729_997e_4785_92a7_a0b91249ee2c
constant: false
initial concentration: NaN
is: Q14032
initial amount: NaN
is encoded by: hsa:570
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: BAAT

http://identifiers.org/biomodels.db/MODEL1310110060#_b0a26279_dc7a_4c70_b441_2cea71440a87
initial amount: NaN
constant: false
is: SBO:0000252
name: ABAT
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:18
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_70ad3963_55bf_4c6a_9126_4e7e4b1622f3
is encoded by: hsa:9245
constant: false
initial concentration: NaN
name: GCNT3
is: O95395
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaR N4Tg
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
reversible: false
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110060#

metaR CHOLt4
fast: false
kinetic law: MODEL1310110060#
type: Reaction
name: choline, sodium cotransport
reversible: true
modifier: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_991fc4dc_5fe8_473f_a2e5_340b99ff7826
boundary condition: true
constant: false
has only substance units: false
is: Q99999
is encoded by: hsa:9514
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: GAL3ST1

http://identifiers.org/biomodels.db/MODEL1310110060#_ad8b59a6_23ef_411c_875a_a2d8c4f75ea5
is encoded by: hsa:4831
initial concentration: NaN
constant: false
name: NME2
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: P22392
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_a97f9f57_37e1_4f68_861b_e74fff5b041b
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: O14735
type: Species
name: CDIPT
is encoded by: hsa:10423
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_82dcc6f4_c970_4051_b49b_88cba22ac5ee
is: SBO:0000252
type: Species
boundary condition: true
name: _AF116616_1_m
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AF116616

http://identifiers.org/biomodels.db/MODEL1310110060#_193bcac8_17bc_4ca1_b3c7_7c03f94523e7
has only substance units: false
boundary condition: true
name: _100128062_1_m
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:100128062
is: SBO:0000252
constant: false

metaR r1299
is: SBO:0000185
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
name: Vesicular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
reactant: MODEL1310110060#
type: Reaction

metaR ARGtm
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is: SBO:0000185
name: arginine mitochondrial transport via ornithine carrier
is described by: ECO:0000269
type: Reaction

metaM L2aadp6sa c
name: L-allysine
initial concentration: 1.0
is: HMDB01263
type: Species
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: CHEBI:17917
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_546c0624_800a_41ec_98a9_86cdc8667b87
initial amount: NaN
initial concentration: NaN
is: Q7KZA3
is: SBO:0000252
is encoded by: hsa:2235
type: Species
boundary condition: true
constant: false
name: FECH
has only substance units: false

metaM fe2 e
initial concentration: 1.0
is: HMDB00692
is: CHEBI:29033
initial amount: NaN
is: C00023
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
type: Species
name: Fe2+
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR r1829
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
reversible: false
modifier: MODEL1310110060#
name: Y+LAT2 Utilized transport
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110060#
is: SBO:0000185

metaM ksi deg26 l
type: Species
is: CHEBI:58343
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 26
constant: false
boundary condition: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: HMDB00061

metaR ITPtn
product: MODEL1310110060#
name: ITP nuclear transport
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_187d5b4e_e2f9_4433_8514_514b98a225f3
is encoded by: hsa:10327
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: AKR1A1
constant: false
boundary condition: true
is: SBO:0000252

metaM 1pipdn2c x
type: Species
initial concentration: 1.0
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: CHEBI:16187
is: SBO:0000247
name: 1-piperideine-2-carboxylate
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01084
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f2527f28_cd99_44ad_ab65_a25b45735cb3
is encoded by: hsa:6532
name: SLC6A4
boundary condition: true
initial concentration: NaN
is: P31645
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species

metaM 11 cis retfa e
is: HMDB00972
constant: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
has only substance units: false
name: fatty acid 11-cis-retinol
initial amount: NaN
is: CHEBI:57454
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247

metaR CDS
is described by: ECO:0000000
modifier: MODEL1310110060#
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.41
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
name: phosphatidate cytidylyltransferase
product: MODEL1310110060#
reactant: MODEL1310110060#

metaM HC02214 e
is: CHEBI:28852
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
type: Species
name: prostaglandin-f1alpha
initial concentration: 1.0
initial amount: NaN

metaM ru5p D c
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: SBO:0000247
name: D-ribulose 5-phosphate(2-)
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: HMDB00618

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR PRPPS
name: phosphoribosylpyrophosphate synthetase
is version of: http://identifiers.org/ec-code/2.7.6.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110060#
is: SBO:0000176
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_ec57f430_3d39_4f08_bf42_82ff7d27bd1a
is encoded by: hsa:178
type: Species
name: AGL
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_c81dcf8d_9d41_4cde_9bae_146683f90010
constant: false
type: Species
boundary condition: true
is: SBO:0000297
is encoded by: hsa:4830
name: NME1:NME2
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM prostgh2 e
is: HMDB01381
constant: false
is: CHEBI:57405
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
name: prostaglandin H2(1-)

metaM meoh c
name: methanol
has only substance units: false
initial amount: NaN
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: HMDB01875
is: CHEBI:17790
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

metaM his L m
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: SBO:0000247
type: Species
is: CHEBI:15971
name: L-histidine
constant: false
initial concentration: 1.0
is: HMDB00177
initial amount: NaN
boundary condition: false

metaM no c
boundary condition: false
initial amount: NaN
is: CHEBI:16480
has only substance units: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
type: Species
name: Nitric oxide
is: C00533
is: SBO:0000247
is: HMDB03378
constant: false
initial concentration: 1.0

metaR UDPG4E
is version of: http://identifiers.org/ec-code/5.1.3.2
fast: false
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000134
name: UDPglucose 4-epimerase
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
reversible: true

metaM bamppald c
is: HMDB01106
is: C05665
is: SBO:0000247
name: beta-Aminopropion aldehyde
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
has only substance units: false
is: http://identifiers.org/pubchem.compound/7975
constant: false

metaM ksi deg3 l
is: HMDB01166
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57316
boundary condition: false
name: keratan sulfate I, degradation product 3
has only substance units: false
is: SBO:0000247
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
initial amount: NaN

metaR RE3347C
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
type: Reaction
name: RE3347
is: SBO:0000176
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_465c0725_6f98_480b_a045_7c96d169cb69
name: _H17063_1_m
is encoded by: hsa:H17063
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaR GGH 10FTHF7GLUe
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110060#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110060#
reversible: false

metaM ksi pre15 g
is: HMDB00175
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: C00130
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 15
constant: false

metaM ade c
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: HMDB00034
is: CHEBI:16708
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C00147
type: Species
name: Adenine
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_65224dc8_95e5_4435_9e84_f0df8de74b70
name: ZADH2
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:284273
is: Q8N4Q0
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_817919ec_d035_43e5_b2bb_ad432c67c056
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5152
type: Species
boundary condition: true
is: SBO:0000252
name: PDE9A
constant: false
has only substance units: false

metaR GLYt2r
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
modifier: MODEL1310110060#
name: glycine reversible transport via proton symport
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304

metaM 3ddcrn c
notes: FORMULA: C19H37NO5 CHARGE: 0
name: 3-hydroxydodecanoylcarnitine
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB04047
is: C14143
initial concentration: 1.0
constant: false

metaM C04849 e
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: CHEBI:57449
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_7157d3ee_402b_46f9_becd_ef9c4fc3e4f6
type: Species
boundary condition: true
constant: false
name: ACLY
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:47
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_1d280e50_65af_41d0_b663_de0c8379fe82
has only substance units: false
is: Q6IBC4
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4726
name: NDUFS6

metaR NACHEX18ly
modifier: MODEL1310110060#
reversible: false
kinetic law: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_124a14b2_8ba0_494d_a09e_0c16178b4ece
is encoded by: hsa:4710
boundary condition: true
type: Species
is: O95168
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: NDUFB4

metaR ADRNCOAtx
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
name: fatty acid intracellular transport
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR DINt
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoxyinosine transport via diffusion
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
product: MODEL1310110060#

metaR FAOXC2252053m
modifier: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
reversible: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110060#

metaR ACNAMPH
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
reversible: false
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_c5710020_78e0_4e06_843f_c2cf6b21efcc
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC25A15
boundary condition: true
is: Q9Y619
is encoded by: hsa:10166
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_53fac3f9_3ef8_4443_baa6_538ef89b8914
name: B3GNT2
constant: false
is encoded by: hsa:10678
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57795
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
constant: false

metaR UMPK5n
fast: false
is: SBO:0000176
product: MODEL1310110060#
name: UMP kinase (dATP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110060#

metaR PCHOLPm hs
is described by: ECO:0000269
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110060#
reversible: false
name: choline phosphatase
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_dbe7f156_3a91_4ec6_a22d_fe4bad27b9c6
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q86YT5
constant: false
is encoded by: hsa:284111
name: SLC13A5
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_cf855819_13cf_4e61_b4ee_4ca1173917d9
initial concentration: NaN
type: Species
boundary condition: true
is: Q16718
constant: false
is encoded by: hsa:4698
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: NDUFA5

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR DHPR2
name: 6,7-dihydropteridine reduction
reversible: false
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110060#

metaM 3hddcoa c
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: C14143
initial amount: NaN
constant: false
is: HMDB04047
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_58732cb1_ee82_4305_bd47_e84995d5d6b9
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: _AI601100_1_m
is encoded by: hsa:AI601100

http://identifiers.org/biomodels.db/MODEL1310110060#_45fc31d3_af1a_48fc_b091_af72b44dda67
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:2974
initial concentration: NaN
has part: D6RDW3
boundary condition: true
is: SBO:0000297
name: GUCY1B2:GUCY1A3
constant: false
is encoded by: hsa:2982

http://identifiers.org/biomodels.db/MODEL1310110060#_9977979f_7716_47ab_a19a_683e5c0bd301
is: SBO:0000252
is encoded by: hsa:6508
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SLC4A3
constant: false
is: P48751

metaM Asn X Ser Thr l
name: protein-linked asparagine residue (N-glycosylation site)
is: C01342
notes: FORMULA: XH CHARGE: 0
type: Species
has only substance units: false
is: CHEBI:28938
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00051

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_68fb460e_2318_4100_b0a2_0912c2aec736
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NT5C3
is: SBO:0000252
is encoded by: hsa:51251
type: Species
constant: false
boundary condition: true
is: Q9H0P0

metaM arachdcoa r
is: CHEBI:57368
type: Species
constant: false
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06523

http://identifiers.org/biomodels.db/MODEL1310110060#_44f32e8b_c823_4c84_a8aa_86d8da4dd7fa
is encoded by: hsa:10380
has only substance units: false
constant: false
initial concentration: NaN
name: BPNT1
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: O95861

http://identifiers.org/biomodels.db/MODEL1310110060#_d78f5a65_2997_45f8_9a67_0d9dcee112cd
is: P49448
initial concentration: NaN
has only substance units: false
name: GLUD2
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:2747
initial amount: NaN

metaR LCADi
is described by: ECO:0000304
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
product: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
name: lactaldehyde dehydrogenase
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: false
modifier: MODEL1310110060#

metaR P45027A11m
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000269
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
type: Reaction
fast: false
kinetic law: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
product: MODEL1310110060#
modifier: MODEL1310110060#

metaR CYTK8n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
name: cytidylate kinase (CMP,dATP),nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

metaR DNDPt28m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reversible: false
name: dCDP transport via dGDP antiport
is: SBO:0000185
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_9fe13cc2_a398_4b2e_8214_1af4eb360bd8
is: P48764
constant: false
is encoded by: hsa:6550
type: Species
initial concentration: NaN
name: SLC9A3
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR BPNT
name: 3',5'-bisphosphate nucleotidase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.3.7
reversible: false
reactant: MODEL1310110060#
is described by: ECO:0000269
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
type: Reaction

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaM 4aphdob c
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: HMDB00978
has only substance units: false
constant: false
is: CHEBI:58147
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate

http://identifiers.org/biomodels.db/MODEL1310110060#_e3855fe6_b3e6_467e_95ea_cf3e2c566ee9
has only substance units: false
initial amount: NaN
is encoded by: hsa:51727
name: CMPK1
is: B2R6S5
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM HC02214 c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
boundary condition: false
is: CHEBI:28852
constant: false
initial concentration: 1.0
name: prostaglandin-f1alpha
type: Species

metaM ksii core2 pre3 g
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C47H76N4O33X CHARGE: -1
has only substance units: false
is: HMDB00175
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110060#_32fadd3b_b140_4e2c_adc9_7b302cf47add
initial amount: NaN
is: SBO:0000252
is: Q549M5
constant: false
has only substance units: false
is encoded by: hsa:4718
initial concentration: NaN
boundary condition: true
name: NDUFC2
type: Species

metaR DOLGLCP Uter
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
fast: false
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reversible: false

metaM ade e
type: Species
name: adenine
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16708
has only substance units: false
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial amount: NaN
is: HMDB00034

metaM 3ddcrn e
is: C14143
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C19H37NO5 CHARGE: 0
name: 3-hydroxydodecanoylcarnitine
boundary condition: false
initial amount: NaN
is: HMDB04047

metaM Ser Gly Ala X Gly l
notes: FORMULA: XH CHARGE: 0
constant: false
is: CHEBI:17650
initial amount: NaN
is: HMDB00063
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: protein-linked serine residue (glycosaminoglycan attachment site)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_db26c035_c13a_4ec2_b95b_f820e3963bfc
name: ENPP3
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:5169
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q308M7

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR PAIL45P HStn
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
fast: false
reversible: true
reactant: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_303a9e9b_6243_4a60_a55f_8474d9015857
is encoded by: hsa:5335
name: PLCG1
type: Species
constant: false
has only substance units: false
boundary condition: true
is: Q9UFY1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_45e5ad88_2689_49ff_b25c_c196fcb2655d
has only substance units: false
initial amount: NaN
constant: false
name: GPX4
is encoded by: hsa:2879
boundary condition: true
is: P36969
initial concentration: NaN
is: SBO:0000252
type: Species

metaR AKGMALtm
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
modifier: MODEL1310110060#
is described by: ECO:0000269
name: alpha-ketoglutarate/malate transporter
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000185
reversible: true

metaR FCLTm
modifier: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
name: Ferrochelatase, mitochondrial
is version of: http://identifiers.org/ec-code/4.99.1.1
reversible: false
type: Reaction

metaR NDPK9n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000269
reversible: true
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear

metaR DNDPt15m
modifier: MODEL1310110060#
is described by: ECO:0000269
reversible: false
is: SBO:0000185
name: dUDP transport via dGDP antiport
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction

metaR CO2t
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
kinetic law: MODEL1310110060#
name: CO2 transporter via diffusion
reversible: true
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_059ecd05_4f86_40d1_b96f_2286b0fba00d
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: _2544_1_c
constant: false
is encoded by: hsa:2544

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_ef088194_a0ad_42a1_a3c1_cc75c5eca9fc
is: Q53H96
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:65263
has only substance units: false
initial amount: NaN
name: PYCRL
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_8c21327d_38d7_4008_96e6_073f3efb9b8a
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:6448
initial concentration: NaN
type: Species
is: P51688
is: SBO:0000252
has only substance units: false
name: SGSH

http://identifiers.org/biomodels.db/MODEL1310110060#_10e28b4b_8e1c_43da_a025_e4de15044930
has only substance units: false
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:55350
boundary condition: true
type: Species
constant: false
name: VNN3:VNN2:VNN1

metaR GGH 6DHFe
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
fast: false
type: Reaction

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR r0829
fast: false
modifier: MODEL1310110060#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.37
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#

metaM dump n
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
is: HMDB01409
type: Species
is: CHEBI:246422
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: dUMP(2-)

metaR r0330
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
modifier: MODEL1310110060#
reversible: false

metaM ppcoa m
boundary condition: false
name: Propanoyl-CoA
is: C00100
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01275
initial concentration: 1.0
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaR UDPGLCAter
type: Reaction
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
kinetic law: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
is: SBO:0000185
fast: false

metaR HAS2
is described by: ECO:0000269
kinetic law: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.212
type: Reaction
modifier: MODEL1310110060#
reversible: false
product: MODEL1310110060#
name: hyaluronan synthase
is: SBO:0000185
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD

metaR MI1PS
modifier: MODEL1310110060#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
reactant: MODEL1310110060#
name: myo-Inositol-1-phosphate synthase
product: MODEL1310110060#
is described by: ECO:0000269
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/5.5.1.4
fast: false
type: Reaction

metaR r0119
reactant: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_73389bbd_4d46_4b67_9106_775d2fa179d4
constant: false
is encoded by: hsa:9107
has only substance units: false
name: MTMR6
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9Y217
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_67f5902f_367c_42dd_948d_10b6ead14884
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM ptth c
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
boundary condition: false
name: pantetheine
is: CHEBI:16753
constant: false
type: Species
initial concentration: 1.0
is: HMDB03426

metaR GTHP
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
product: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.9
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
reversible: true
is described by: ECO:0000134
type: Reaction
fast: false
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.11.1.12
kinetic law: MODEL1310110060#

metaM ksi deg22 l
name: keratan sulfate I, degradation product 22
is: CHEBI:57455
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
constant: false
is: HMDB01354

http://identifiers.org/biomodels.db/MODEL1310110060#_14a7cb36_69cf_465b_9c4a_95f63fb551d2
constant: false
boundary condition: true
is: SBO:0000252
name: GBA
has only substance units: false
is: B7Z6S1
is encoded by: hsa:2629
initial amount: NaN
initial concentration: NaN
type: Species

metaM ksi deg37 l
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01354
is: CHEBI:57455
notes: FORMULA: C62H104N4O46 CHARGE: 0
constant: false
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I, degradation product 37

metaR KSII CORE4tly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110060#
reversible: false
name: keratan sulfate II (core 4) transport, extracellular to lysosome
product: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_334172bf_c734_4be7_a19d_e9f7677cb6ab
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2954
type: Species
initial concentration: NaN
constant: false
name: GSTZ1

metaM o2 c
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
is: SBO:0000247
is: C00007
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01377
is: CHEBI:15379
name: O2
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_c8913b0b_2784_4c1b_9205_28ddb4e4ba26
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
name: DHCR24
is: SBO:0000252
is encoded by: hsa:1718
is: Q15392

metaR r0472
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
kinetic law: MODEL1310110060#
fast: false
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176

metaM utp n
name: UTP(4-)
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:46398
is: HMDB00285
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_6c5eccea_0db7_40f4_b202_1c39159d1cfe
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8790
constant: false
name: FPGT
is: O14772
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM malthp e
is: C01936
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
constant: false
type: Species
has only substance units: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: maltoheptaose

metaR GALASE9ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_45107371_7a1f_43cb_9b86_f8f677cace8f
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:27068
constant: false
name: PPA2
initial concentration: NaN

metaR r0698
modifier: MODEL1310110060#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.27
fast: false
reactant: MODEL1310110060#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#

metaR GTMLTe
modifier: MODEL1310110060#
is: SBO:0000185
reversible: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
is version of: http://identifiers.org/ec-code/2.3.2.2
is described by: ECO:0000269
name: g-glutamyltransferase (e)
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction

metaM xtsn c
is: HMDB00299
constant: false
type: Species
initial concentration: 1.0
name: xanthosine
is: CHEBI:18107
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762

metaR r1561
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_d5593079_1641_4223_bf5d_74d0ffc692b2
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:126328
constant: false
is: C9JT23
is: SBO:0000252
name: NDUFA11
initial concentration: NaN
has only substance units: false

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaR S6TASE23ly
modifier: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110060#
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction

metaR RE3004M
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is: SBO:0000176
reactant: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: RE3004

metaM ddcacoa x
initial concentration: 1.0
is: CHEBI:57375
is: C01832
type: Species
has only substance units: false
boundary condition: false
is: HMDB03571
is: SBO:0000247
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial amount: NaN

metaR r1292
fast: false
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Postulated transport reaction
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: true

metaM adp m
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:456216
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C00008
type: Species
is: http://identifiers.org/pubchem.compound/3310
name: ADP
is: HMDB01341

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaR r2309
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_133a4315_6387_4a7d_954d_51ae69c98ab1
initial amount: NaN
is: P51687
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6821
initial concentration: NaN
name: SUOX
has only substance units: false
type: Species

metaM ppcoa x
constant: false
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
is: HMDB01275
name: Propanoyl-CoA
has only substance units: false
is: SBO:0000247
is: CHEBI:57392
boundary condition: false
is: C00100
type: Species

metaR M4MPDOL Uter
type: Reaction
reactant: MODEL1310110060#
reversible: false
name: m4mpdol flippase
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false

metaR RBTt
type: Reaction
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
name: ribitol transport via passive diffusion
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

metaR GTHO
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
reversible: false
reactant: MODEL1310110060#
is described by: ECO:0000254
name: glutathione oxidoreductase

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaM ser L e
type: Species
constant: false
boundary condition: false
is: CHEBI:17115
is: SBO:0000247
name: L-serine
has only substance units: false
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial concentration: 1.0
initial amount: NaN

metaM omhpal c
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: w-hydroxypalmiticacid
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H30O3 CHARGE: -1
is: HMDB06294

metaR r1560
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185

metaR NACHEX25ly
reactant: MODEL1310110060#
fast: false
reversible: false
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM chol c
is: SBO:0000247
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: Choline
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00097
type: Species
is: C00114

metaR r1291
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110060#
name: Postulated transport reaction
is described by: ECO:0000000
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#

metaM cholcoar x
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
is: SBO:0000247
is: HMDB02178
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58677
constant: false

metaM o2 e
initial concentration: 1.0
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
is: C00007
boundary condition: false
name: O2
is: CHEBI:15379
is: HMDB01377
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR r2308
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#

metaM ksii core4 pre1 g
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: SBO:0000247
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 1
constant: false
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110060#_06e4f9d9_8e3c_4abf_b3d0_a402346f5eb0
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM C05957 r
initial amount: NaN
name: Prostaglandin J2
constant: false
boundary condition: false
is: CHEBI:27485
is: SBO:0000247
is: HMDB02710
has only substance units: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
initial concentration: 1.0

metaR HDCEAtr
name: fatty acid transport via diffusion
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_c4fd81f4_84bc_4618_899d_82a75e7b4436
initial amount: NaN
name: BTD
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:686
is: SBO:0000252
is: P43251
type: Species

metaR r2023
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
reversible: false
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction

metaM adp n
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01341
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
is: SBO:0000247
name: ADP(3-)
constant: false

metaR GBA
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
reactant: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
is: SBO:0000176
reversible: false
name: Glucosylceramidase
is described by: ECO:0000000
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.45

http://identifiers.org/biomodels.db/MODEL1310110060#_6e58e976_acd0_48d7_86b2_1ad97c2538b0
has only substance units: false
is encoded by: hsa:4126
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: MANBA
is: O00462
initial amount: NaN
is: SBO:0000252

metaR r0580
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.99.7
reversible: true
product: MODEL1310110060#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_12d5b777_83cc_43bc_8c6e_29ecef638846
has only substance units: false
is: SBO:0000252
name: SLC35D1
initial concentration: NaN
is: Q9NTN3
boundary condition: true
type: Species
is encoded by: hsa:23169
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_8f6e185a_706e_4540_ac40_c2b203676d17
is: Q9BX95
boundary condition: true
is: SBO:0000252
is encoded by: hsa:81537
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: SGPP1
initial concentration: NaN

metaM g3m8masn r
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05873
notes: FORMULA: C88H147N2O70X CHARGE: 0
has only substance units: false

metaR RE1447N
is: SBO:0000176
name: RE1447
reactant: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:

metaR LTD4DP
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
fast: false
is described by: ECO:0000000
name: Leukotriene D4 dipeptidase
type: Reaction
reversible: true
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176

metaM 3hddcoa m
is: HMDB04047
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C14143
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
constant: false

metaR SERtN1
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reversible: true
fast: false
reactant: MODEL1310110060#
name: Serine transport (Na, H coupled)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
is: SBO:0000185
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_29dec728_4f1e_4179_9d78_32d3dd8c75af
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ADCY3
type: Species
is encoded by: hsa:109
boundary condition: true
constant: false
is: SBO:0000252
is: B3KT86

http://identifiers.org/biomodels.db/MODEL1310110060#_397a7ee1_4bb2_404e_97ea_8b2e8391fdbf
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:U37519
has only substance units: false
constant: false
initial amount: NaN
name: _U37519_1_m

metaR MI1PP
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.3.25
product: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: myo-inositol 1-phosphatase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_ec0a4080_8c0d_4aae_8d04_1ee83fd83bd9
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3155
is: Q6IBC0
constant: false
name: HMGCL
is: SBO:0000252
type: Species
initial amount: NaN

metaR BALAtmr
reversible: true
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
name: Beta-alanine reversible mitochondrial transport (diffusion)
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_904be601_b318_49a1_a472_2d52b6ba3f31
has only substance units: false
type: Species
is: Q9UHV8
boundary condition: true
is: SBO:0000252
name: LGALS13
initial concentration: NaN
is encoded by: hsa:29124
initial amount: NaN
constant: false

metaR DHFR
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
name: dihydrofolate reductase
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is described by: ECO:0000254
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_8d8b1173_49c3_47f9_8eac_7a44df0b4549
is: Q9UJM8
is: SBO:0000252
name: HAO1
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:54363
initial amount: NaN
boundary condition: true
has only substance units: false

metaR DHCRD2
fast: false
reactant: MODEL1310110060#
name: dihydroceramide desaturase
modifier: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR r0936
kinetic law: MODEL1310110060#
name: Transport reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: false
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#

metaM vitd3 e
is: CHEBI:28940
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: calciol
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00876

http://identifiers.org/biomodels.db/MODEL1310110060#_2b696724_c307_4c65_9bcf_b918525f764e
initial amount: NaN
boundary condition: true
name: HSD17B4
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: E9PB82
is encoded by: hsa:3295
initial concentration: NaN

metaR RE1447M
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000000
name: RE1447
product: MODEL1310110060#
reversible: true
type: Reaction
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110060#
fast: false

metaR G14T14g
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
product: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f8dae8aa_7825_41aa_9e8d_a95646614e04
name: _AA177072_1_c
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:AA177072
initial concentration: NaN
is: SBO:0000252

metaR r0937
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
reactant: MODEL1310110060#
reversible: true
is described by: ECO:0000000
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_598ff9a1_8483_4205_a186_dff0532c64b9
boundary condition: true
is: SBO:0000252
name: SLC7A8
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: Q9UHI5
is encoded by: hsa:23428

http://identifiers.org/biomodels.db/MODEL1310110060#_a17fb8a8_eba3_41d0_955b_18b3b0c8eb39
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: ST3GAL3
is: SBO:0000252
is encoded by: hsa:6487
initial amount: NaN
boundary condition: true

metaR HEXDIACTD
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaR GCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
name: bile acid intracellular transport
reversible: true
kinetic law: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_4147c7fd_3fab_4337_8668_7637441d3f1f
boundary condition: true
is: P45954
constant: false
is encoded by: hsa:36
initial concentration: NaN
name: ACADSB
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM retn c
is: SBO:0000247
initial amount: NaN
name: all-trans-retinoate
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM glyald c
has only substance units: false
is: CHEBI:17378
name: D-Glyceraldehyde
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: C00577
is: HMDB01051
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_2da2690d_6107_4458_914d_402fa2a29c8b
name: ACAA1
is: Q96CA6
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:30
type: Species

metaR r0113
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110060#
is: SBO:0000176
reversible: false
reactant: MODEL1310110060#
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_b9399b7f_6412_467f_864b_3a6af6905838
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P00568
name: AK1
is encoded by: hsa:203
initial concentration: NaN
constant: false

metaM ksii core2 pre8 g
type: Species
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 8
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: C00130
has only substance units: false
initial concentration: 1.0
is: HMDB00175
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58053

metaM utp c
name: UTP
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
is: C00075
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:46398
type: Species
initial concentration: 1.0

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaM ksi deg41 l
name: keratan sulfate I, degradation product 41
notes: FORMULA: C34H58N2O26 CHARGE: 0
initial concentration: 1.0
is: HMDB00143
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:12936
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_56a35c69_cd00_46aa_b958_febe6b93994a
is: Q02338
name: BDH1
is encoded by: hsa:622
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_0b0a3c67_a332_4d5a_9397_3f3228c0b635
constant: false
name: GYS2
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2998
is: P54840
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_cda22de9_0e80_452c_86ea_7ae1ba6d65a3
type: Species
name: SLC24A1
boundary condition: true
is: B4DUG1
constant: false
is encoded by: hsa:9187
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR P45027A1m
reversible: false
kinetic law: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110060#
name: Cytochrome P450 27
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
type: Reaction

metaM retinal cis 13 r
name: 13-cis-retinal
is: HMDB06220
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
initial amount: NaN
type: Species
is: CHEBI:45487
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_4c727203_f2ab_4479_9d4f_88632ec609ec
initial amount: NaN
name: PPA2
constant: false
is encoded by: hsa:27068
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: F8WDN9

metaM HC02206 e
type: Species
name: prostaglandin C1(1-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57399
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
boundary condition: false

metaM udpglcur c
is: HMDB00935
constant: false
name: UDP-D-glucuronate
has only substance units: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
type: Species
is: CHEBI:58052
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM vitd3 c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28940
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
boundary condition: false
constant: false
name: calciol
has only substance units: false
type: Species
is: HMDB00876

http://identifiers.org/biomodels.db/MODEL1310110060#_d43cb15c_899a_4759_9ce1_c66dcb7a8e97
is: SBO:0000252
is: Q96Q11
is encoded by: hsa:51095
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: TRNT1

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR RE3565C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
type: Reaction
name: RE3565
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_c7509e16_3e69_4d6c_b57c_56921baaeae5
type: Species
is: SBO:0000252
is: O60331
is encoded by: hsa:23396
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: PIP5K1C
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_0085f645_e47b_4ec1_b667_6ab473fb0cf9
type: Species
boundary condition: true
has only substance units: false
name: PDE4D
is: Q08499
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5144

http://identifiers.org/biomodels.db/MODEL1310110060#_a1e8160e_5213_4362_9209_639bb551a5f0
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:84532
boundary condition: true
is: SBO:0000252
type: Species
name: ACSS1
constant: false
is: Q9NUB1

metaM btn m
constant: false
type: Species
is: CHEBI:57586
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00030
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
name: biotinate

metaR r1298
is described by: ECO:0000000
is: SBO:0000185
name: Vesicular transport
reversible: false
kinetic law: MODEL1310110060#
fast: false
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR DCYTt
fast: false
type: Reaction
name: deoxycytidine transport via diffusion
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaM retn e
initial amount: NaN
constant: false
is: HMDB01852
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:35291
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
name: all-trans-retinoate

http://identifiers.org/biomodels.db/MODEL1310110060#_fc3edad5_452b_447f_81d5_2c14c6d8cc41
is encoded by: hsa:4731
type: Species
boundary condition: true
name: NDUFV3
is: P56181
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM utp e
initial concentration: 1.0
constant: false
is: SBO:0000247
name: UTP(4-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
has only substance units: false
type: Species
is: HMDB00285

metaM hpyr c
name: 3-hydroxypyruvate
is: CHEBI:17180
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01352
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
constant: false
has only substance units: false

metaM ser L c
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: L-serine
has only substance units: false
is: SBO:0000247
is: CHEBI:17115
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187

metaM arachdcoa x
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN
is: CHEBI:57368
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
name: arachidonoyl-CoA(4-)
constant: false
initial concentration: 1.0
is: HMDB06523

http://identifiers.org/biomodels.db/MODEL1310110060#_a90bd753_7ae5_4d6e_83b9_cb4132e596a3
name: SLC2A12
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:154091
is: SBO:0000252
is: Q8TD20
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_27284d13_0983_4229_ae20_06c9d2fdc093
initial concentration: NaN
boundary condition: true
name: CHAT
is: Q6LEN5
is encoded by: hsa:1103
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM btn n
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00030
initial amount: NaN
is: CHEBI:57586
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
name: biotinate
constant: false
boundary condition: false

metaM dmnoncrn x
initial amount: NaN
is: SBO:0000247
name: 4,8-dimethylnonanoyl carnitine
notes: FORMULA: C18H37NO4 CHARGE: 0
boundary condition: false
has only substance units: false
is: HMDB06202
constant: false
initial concentration: 1.0
type: Species

metaM ksi pre26 g
is: CHEBI:28067
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 26
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_23d651c0_9a54_497c_9a8d_b1a2cd85a64b
name: NDUFA8
is encoded by: hsa:4702
has only substance units: false
is: B1AM93
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM tym c
boundary condition: false
is: CHEBI:327995
constant: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
name: tyraminium
initial concentration: 1.0
is: HMDB00306

metaM damp c
initial amount: NaN
constant: false
name: dAMP(2-)
is: SBO:0000247
is: CHEBI:58245
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00905
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_58b0ee53_0465_4fda_9021_dc0576cc2e37
is: P49619
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1608
type: Species
initial amount: NaN
constant: false
name: DGKG
has only substance units: false

metaM HC02206 c
name: prostaglandin C1(1-)
has only substance units: false
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR RE3242R
fast: false
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
name: RE3242
reversible: true

metaR r0074
product: MODEL1310110060#
type: Reaction
reversible: true
is: SBO:0000176
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reactant: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110060#

metaR PPPGOm
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
reversible: false
kinetic law: MODEL1310110060#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.3.3.4
name: protoporphyrinogen oxidase, mitochondrial
modifier: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction

metaR NP1
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000304
name: nucleotide phosphatase
type: Reaction

metaR UMPKn
reactant: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is described by: ECO:0000269
reversible: true
name: UMP kinase, nuclear
is: SBO:0000176
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0339
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.22
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110060#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reversible: false
modifier: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction

metaR r1670
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
name: Y+LAT2 Utilized transport

metaM hs deg17 l
initial concentration: 1.0
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
type: Species
constant: false
name: heparan sulfate, degradation product 17
is: SBO:0000247
is: CHEBI:21338
initial amount: NaN
boundary condition: false
is: HMDB02704
has only substance units: false

metaM arach e
initial concentration: 1.0
is: CHEBI:32360
constant: false
initial amount: NaN
boundary condition: false
is: HMDB02212
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
has only substance units: false
is: SBO:0000247
name: arachidate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_faabb574_f738_40d6_acf5_c892488a561f
is encoded by: hsa:56623
is: Q9NRR6
type: Species
boundary condition: true
initial concentration: NaN
name: INPP5E
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f7e69b8e_9252_4cf8_adde_953d51d3e469
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: IDS
is: B4DGD7
initial amount: NaN
type: Species
is encoded by: hsa:3423
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_e455f14e_7a63_4bf6_82a0_b8276ff97027
initial amount: NaN
type: Species
name: SLC24A4
is: Q8NFF2
is: SBO:0000252
is encoded by: hsa:123041
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_0feceb0d_3d64_42ee_8510_53a52517cab2
name: NDUFA6
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: P56556
constant: false
boundary condition: true
is encoded by: hsa:4700
is: SBO:0000252

metaM r5p r
name: alpha-D-Ribose 5-phosphate
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: HMDB00618
has only substance units: false
is: CHEBI:18189
initial concentration: 1.0

metaM HC00319 c
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
is: CHEBI:30794
name: Malonate

http://identifiers.org/biomodels.db/MODEL1310110060#_11a82f6d_ef75_4b42_b491_ff029dd2ad39
name: PTGDS
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: P41222
is encoded by: hsa:5730
is: SBO:0000252
has only substance units: false

metaR S6TASE21ly
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
modifier: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110060#_56e72414_ee68_465f_a345_d930ed79d153
is encoded by: hsa:4726
is: Q6IBC4
type: Species
name: NDUFS6
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaM ru5p D r
boundary condition: false
type: Species
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: CHEBI:58121
initial amount: NaN
has only substance units: false
name: D-ribulose 5-phosphate(2-)
is: HMDB00618
is: SBO:0000247
initial concentration: 1.0

metaM 1pyr5c c
initial amount: NaN
is: C03912
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01301
is: SBO:0000247
has only substance units: false
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_34d8bf41_829a_4618_91d2_01cc80829636
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: Q9BV79
is encoded by: hsa:51102
name: MECR
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_f679631d_c06f_4e96_bca5_aafe9799b91a
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is: Q9UI40
is encoded by: hsa:25769
boundary condition: true
name: SLC24A2

metaR OMHPALTD
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM HC02217 e
boundary condition: false
is: CHEBI:27647
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: prostaglandin-g2

metaR r1554
reversible: true
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM f6p c
initial concentration: 1.0
is: CHEBI:57579
constant: false
is: http://identifiers.org/pubchem.compound/3385
is: SBO:0000247
type: Species
boundary condition: false
name: D-Fructose 6-phosphate
is: C00085
has only substance units: false
initial amount: NaN
is: HMDB00124

metaR r1662
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
fast: false

metaR r2509
reactant: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM retn r
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
is: CHEBI:35291
is: SBO:0000247
name: all-trans-retinoate
is: HMDB01852
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM tsul c
is: SBO:0000247
initial amount: NaN
is: HMDB00257
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
name: thiosulfate(2-)
is: CHEBI:16094
type: Species
boundary condition: false
constant: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR PAPtg
name: adenosine 3',5'-bisphosphate Golgi transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000185

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_ce629ec0_9669_4a13_9906_21cac1213675
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: EHHADH
is encoded by: hsa:1962
is: Q9NY65
type: Species

metaR H2Otg
type: Reaction
kinetic law: MODEL1310110060#
fast: false
name: H2O transport, Golgi apparatus
is: SBO:0000185
reversible: true
reactant: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM adp c
is: http://identifiers.org/pubchem.compound/3310
is: SBO:0000247
type: Species
is: CHEBI:16761
initial amount: NaN
is: C00008
initial concentration: 1.0
is: HMDB01341
name: ADP
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_ac106cf8_c913_4ffb_8d5e_08e9d62169d2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC22A1
initial amount: NaN
is: O15245
is encoded by: hsa:6580
type: Species
constant: false
has only substance units: false

metaM tmndnccoa m
is: SBO:0000247
has only substance units: false
constant: false
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
boundary condition: false
is: HMDB06514
type: Species
initial concentration: 1.0

metaM m6mpdol U r
has only substance units: false
boundary condition: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: CHEBI:37635
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20

metaM udp e
is: CHEBI:58223
name: UDP(3-)
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00295
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
constant: false

metaR r1661
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaM glyb c
type: Species
is: CHEBI:17750
is: SBO:0000247
boundary condition: false
name: glycine betaine
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043

http://identifiers.org/biomodels.db/MODEL1310110060#_82696104_13a8_495e_a7c7_d5443c51d28d
type: Species
is encoded by: hsa:AA977580
initial amount: NaN
constant: false
has only substance units: false
name: _AA977580_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM tchola c
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
name: taurocholic acid
is: SBO:0000247
is: HMDB00036
is: CHEBI:36257
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
boundary condition: false

metaR HS2ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.10.1.1
reversible: false
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r2508
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
name: Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
reversible: true
is: SBO:0000185

metaR RE3524R
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110060#
reversible: true
name: RE3524

http://identifiers.org/biomodels.db/MODEL1310110060#_5766d0bc_53ad_4032_b4fe_03d80688e21d
is encoded by: hsa:2030
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SLC29A1
is: Q99808

metaR RE3567C
fast: false
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000176
type: Reaction
name: RE3567
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_b614a802_9622_4517_b9d9_e5a441fa42e1
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:8802
is: P53597
name: SUCLG1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_92406133_1baf_4734_ad77_a3d3eed05d37
has only substance units: false
is encoded by: hsa:FLJ44968
boundary condition: true
name: _FLJ44968_1_m
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species

metaM lys L e
type: Species
is: CHEBI:32551
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
initial amount: NaN
name: L-lysinium(1+)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_e9c052b3_db82_4283_b688_bfd624b3b306
is: SBO:0000252
boundary condition: true
name: SLC5A11
is encoded by: hsa:115584
initial amount: NaN
has only substance units: false
is: Q8WWX8
constant: false
type: Species
initial concentration: NaN

metaR S6T17g
product: MODEL1310110060#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reversible: false
fast: false

metaR PYK
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: pyruvate kinase
modifier: MODEL1310110060#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110060#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110060#_686b072d_82dc_4a0b_8add_11e2b12ac3b7
boundary condition: true
has only substance units: false
name: PMM1
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is: A8K003
is encoded by: hsa:5372
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_c70ebe09_1095_4b95_8d1d_484515a962d6
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:10164
is: Q8NCG5
initial concentration: NaN
initial amount: NaN
name: CHST4
has only substance units: false

metaR r1556
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110060#

metaM lnlnca c
initial concentration: 1.0
is: CHEBI:32387
is: HMDB01388
name: alpha-linolenate
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_27fe0c9c_3f44_47bf_b107_8b899cb11217
initial amount: NaN
constant: false
initial concentration: NaN
is: B4DK61
name: ACOX1
is encoded by: hsa:51
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaR Coqe
is: SBO:0000185
product: MODEL1310110060#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Transport of q10
reversible: true
is described by: ECO:0000134

metaR r0575
modifier: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
reversible: true

metaM HC02217 c
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-g2
is: CHEBI:27647
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

http://identifiers.org/biomodels.db/MODEL1310110060#_5af70a64_d6d8_4b7b_a79f_fc53d67e6ad0
has only substance units: false
initial amount: NaN
is: Q9HBH5
name: RDH14
is: SBO:0000252
is encoded by: hsa:57665
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaM ppbng c
constant: false
is: CHEBI:58126
name: Porphobilinogen
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
initial concentration: 1.0
boundary condition: false
is: HMDB00245
is: C00931
type: Species

metaR r2507
reactant: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR RE1254C
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110060#
name: RE1254
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
reversible: true

metaR NH4t3r
kinetic law: MODEL1310110060#
is described by: ECO:0000269
reactant: MODEL1310110060#
name: ammonia transport via proton antiport
reversible: true
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
product: MODEL1310110060#

metaR FUMSO3tm
modifier: MODEL1310110060#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
name: Fumarate:sulfite antiport, mitochondrial
product: MODEL1310110060#
reactant: MODEL1310110060#

metaR r1660
is: SBO:0000185
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110060#_d5760721_ed27_470e_8007_7ca6bb5f2d0d
is: SBO:0000252
is encoded by: hsa:205
has only substance units: false
initial amount: NaN
name: AK4
is: P27144
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaR ACOAD9m
kinetic law: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000269
reactant: MODEL1310110060#
reversible: false
fast: false
modifier: MODEL1310110060#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110060#_86fb8174_525b_43da_b11b_37bfefd86ec6
is: Q7LG56
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:50484
name: RRM2B
constant: false
type: Species

metaM ksi pre31 g
initial amount: NaN
is: HMDB00175
constant: false
type: Species
is: C00130
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
boundary condition: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 31
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_0d0a2c21_f975_4711_b10b_de6e45d97955
is encoded by: hsa:5152
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110060#_a1f08979_48ba_424f_a00e_d50e56e769e1
boundary condition: true
initial amount: NaN
name: AKR7A2
is: SBO:0000252
is: O43488
is encoded by: hsa:8574
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaM dump c
initial amount: NaN
is: HMDB01409
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
is: SBO:0000247
boundary condition: false
is: C00365
is: CHEBI:246422
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

metaR r1557
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#

metaM udp g
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00295
type: Species
initial concentration: 1.0
name: UDP(3-)
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
is: CHEBI:58223

metaR HSD3A1r
reversible: true
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110060#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.225

metaR Q10H2e
product: MODEL1310110060#
reversible: true
name: transport of ubiquinol into lymph
fast: false
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

http://identifiers.org/biomodels.db/MODEL1310110060#_c694bc38_4f71_40b7_93c8_deb6aeaa89d2
constant: false
is: Q9NY28
is encoded by: hsa:26290
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: GALNT8

metaR r2506
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Utilized transport
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185

metaM hs deg3 l
initial concentration: 1.0
is: CHEBI:16126
constant: false
type: Species
name: heparan sulfate, degradation product 3
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_d5b43cc1_9b1d_4eba_8fd5_cfdb6137928a
type: Species
initial amount: NaN
is encoded by: hsa:8402
is: SBO:0000252
constant: false
is: F5GY65
boundary condition: true
initial concentration: NaN
name: SLC25A11
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_60db4ac1_2170_4974_89cb_099c370d1617
initial concentration: NaN
name: CTH
is: P32929
boundary condition: true
is encoded by: hsa:1491
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_083671be_3949_43b7_9454_6704040d0f74
is: SBO:0000252
is: P04746
is encoded by: hsa:279
type: Species
has only substance units: false
name: AMY2A
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_b1744b02_a8f4_4ca3_ae12_ec22a35e0e38
boundary condition: true
is encoded by: hsa:6480
initial amount: NaN
has only substance units: false
is: B2R513
constant: false
is: SBO:0000252
name: ST6GAL1
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_0fab5805_f9e7_43f9_b7c3_85c17fcaae5b
is: SBO:0000252
is: B4DFS7
has only substance units: false
is encoded by: hsa:2530
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: FUT8

metaR DCSPTN1CRNt
is: SBO:0000185
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
reversible: false
modifier: MODEL1310110060#
fast: false
product: MODEL1310110060#

metaR F1Atg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110060#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction
name: F1alpha transport (from golgi to lysosome)
reactant: MODEL1310110060#

metaM hmgcoa c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
constant: false
boundary condition: false
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
type: Species
is: CHEBI:15467
is: SBO:0000247

metaM ksii core2 g
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
is: CHEBI:57255
name: keratan sulfate II (core 2-linked)
has only substance units: false
constant: false
type: Species
is: HMDB01014

metaR r1666
is described by: ECO:0000000
modifier: MODEL1310110060#
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_a7ae4684_c4a4_4428_b3d3_d7a9fa9349bc
is: B7Z9T9
is encoded by: hsa:5158
is: SBO:0000252
name: PDE6B
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaM odecoa m
is: CHEBI:57387
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
has only substance units: false
constant: false

metaM dhap c
type: Species
name: Dihydroxyacetone phosphate
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
constant: false
initial amount: NaN
is: CHEBI:57642
is: HMDB01473
is: C00111
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r2443
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5

http://identifiers.org/biomodels.db/MODEL1310110060#_139ff811_83d6_4711_ba17_defe2e29374d
is encoded by: hsa:123041
constant: false
boundary condition: true
is: SBO:0000252
name: SLC24A4
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaR CYSTA
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
name: cysteine transaminase
modifier: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
fast: false

metaR ALR2
product: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110060#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110060#
name: aldose reductase (methylglyoxal)
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_19c8da87_a78e_4302_b43e_04ec48dfd99c
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: _AI972237_1_c
is encoded by: hsa:AI972237
has only substance units: false
type: Species
initial amount: NaN

metaR RE3003M
fast: false
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
reversible: true
is: SBO:0000176
name: RE3003

metaM thf e
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: SBO:0000247
is: CHEBI:57453
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01846
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_048b0e1d_fdf6_4bdb_bfd4_01a75c61783d
is: Q9C0J1
has only substance units: false
boundary condition: true
is encoded by: hsa:79369
initial concentration: NaN
type: Species
constant: false
name: B3GNT4
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_dd242894_36fd_4850_923f_e0accf6b22ac
initial amount: NaN
is encoded by: hsa:11001
boundary condition: true
initial concentration: NaN
is: O14975
type: Species
name: SLC27A2
is: SBO:0000252
has only substance units: false
constant: false

metaR 2DR1PP
reversible: false
is: SBO:0000176
reactant: MODEL1310110060#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
kinetic law: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
product: MODEL1310110060#
is described by: ECO:0000000
fast: false

metaM 5oxpro e
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 5-oxoprolinate
is: CHEBI:57606
is: HMDB00267

http://identifiers.org/biomodels.db/MODEL1310110060#_766f9ff3_a235_4124_ba75_3799d8c43176
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: CH25H
has only substance units: false
is: O95992
constant: false
is encoded by: hsa:9023
initial amount: NaN

metaR r1551
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM btn e
type: Species
is: HMDB00030
has only substance units: false
is: CHEBI:3420
boundary condition: false
is: C00120
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial amount: NaN
name: Biotin
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR r1665
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_e5d68660_e918_4c0a_87f3_51445441c3c3
type: Species
has only substance units: false
is: SBO:0000252
name: AKR1D1
initial concentration: NaN
is: P51857
initial amount: NaN
is encoded by: hsa:6718
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_afadb92d_d8ab_41bc_9847_018e8e788d39
type: Species
constant: false
initial concentration: NaN
name: EGFL8
has only substance units: false
is encoded by: hsa:80864
is: Q99944
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR PPD2CSPp
kinetic law: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
fast: false
name: PPD2CSPp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reversible: false

metaR CERT1gt
name: ceramide transport protein
fast: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000304
reversible: true
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_b137b33d_aeab_418b_b385_3113db57ac01
name: SLC27A1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:376497

metaM CE5236 n
is: CHEBI:28002
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
type: Species
is: HMDB03952
name: O2'-4a-cyclic-tetrahydrobiopterin
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR RE2626C
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is described by: ECO:0000000
reversible: true
name: RE2626
kinetic law: MODEL1310110060#

metaR DADNt4
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
reversible: true
name: deoxyadenosine transport via diffusion
is described by: ECO:0000000
fast: false

metaR RE3624M
reactant: MODEL1310110060#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
name: RE3624
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176

metaR S6T4g
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
fast: false
is: SBO:0000176

metaR r1664
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110060#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: true
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false

metaR RE1233C
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
name: RE1233
type: Reaction
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
reversible: true
modifier: MODEL1310110060#

metaR r1552
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_c7843182_88ad_4e82_a696_82d65cd4543f
is: Q6P1K9
boundary condition: true
name: PANK2
is encoded by: hsa:80025
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM dolp U r
initial amount: NaN
boundary condition: false
name: dolichyl phosphate(2-)
is: SBO:0000247
is: CHEBI:57683
type: Species
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
has only substance units: false
constant: false

metaM ksii core2 pre1 g
type: Species
is: CHEBI:28067
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H53N3O23X CHARGE: -1
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 1

metaM dhap e
is: SBO:0000247
name: glycerone phosphate(2-)
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
constant: false
initial amount: NaN
is: HMDB01473
is: CHEBI:57642
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species

metaM g2m8masn r
type: Species
boundary condition: false
is: C05874
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C82H137N2O65X CHARGE: 0
has only substance units: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN

metaM ksii core2 e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
name: keratan sulfate II (core 2-linked)
is: CHEBI:17268
has only substance units: false
type: Species
constant: false
is: HMDB00211

http://identifiers.org/biomodels.db/MODEL1310110060#_f9bb16a5_4139_4d69_a186_52c56763c518
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PLCH2
constant: false
initial amount: NaN
is encoded by: hsa:9651
is: O75038
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_96f051dc_7744_4aec_968e_196c4134f4c5
name: SHMT2
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6472
constant: false
is: B4DJQ3

metaM 4abut m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
initial amount: NaN
type: Species
is: HMDB00112
is: CHEBI:16865
initial concentration: 1.0
name: 4-Aminobutanoate
has only substance units: false
constant: false
is: C00334

metaM ksi deg5 l
is: CHEBI:12936
type: Species
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: HMDB00143
name: keratan sulfate I, degradation product 5
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN

metaR 5MTHFt2le
name: 5-methyltetrahydrofolate transport via anion exchange
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110060#

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaM thf c
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453
constant: false
is: HMDB01846
type: Species
is: C00101
initial concentration: 1.0
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
boundary condition: false
initial amount: NaN
has only substance units: false

metaM 5oxpro c
initial amount: NaN
is: HMDB00267
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: 5-oxoprolinate
is: SBO:0000247
is: CHEBI:57606

http://identifiers.org/biomodels.db/MODEL1310110060#_8106b95d_d1d1_483a_a06c_a2649ae8c615
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4711
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: NDUFB5
is: O43674

metaM dopa c
name: dopaminium(1+)
has only substance units: false
is: HMDB00073
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:59905
type: Species

metaM ksi deg35 l
constant: false
name: keratan sulfate I, degradation product 35
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00143
type: Species
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
is: CHEBI:12936
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_d7945033_968a_45d8_a9a5_f8f817042e98
constant: false
boundary condition: true
name: NDUFS8
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4728
is: O00217

http://identifiers.org/biomodels.db/MODEL1310110060#_97502356_bfd5_4227_9b5e_98cbbe9153df
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:AA278423
name: _AA278423_1_c
constant: false
boundary condition: true
initial concentration: NaN

metaM btn c
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1
boundary condition: false
is: CHEBI:3420
is: C00120
name: Biotin
initial amount: NaN
initial concentration: 1.0

metaM tchola e
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0
name: taurocholic acid
is: SBO:0000247
is: HMDB00036
has only substance units: false

metaR r1553
reactant: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction

metaM HC01115 c
name: NeuNGc
has only substance units: false
boundary condition: false
is: CHEBI:29025
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: SBO:0000247
constant: false

metaR r0570
modifier: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.3.2
fast: false
is described by: ECO:0000000
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_36008cc5_fe95_4d02_9311_f870cac09025
name: PCBD2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:84105
has only substance units: false
is: SBO:0000252
is: Q9H0N5
type: Species
initial amount: NaN
constant: false

metaR r1776
is: SBO:0000185
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
reversible: false
modifier: MODEL1310110060#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaR SUCOASm
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
modifier: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
name: Succinate--CoA ligase (ADP-forming)
is: SBO:0000176
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is version of: http://identifiers.org/ec-code/6.2.1.4

http://identifiers.org/biomodels.db/MODEL1310110060#_0594df30_bd0f_4bad_8495_8d8048776f91
initial concentration: NaN
is encoded by: hsa:5145
has part: B7Z9T9
is encoded by: hsa:5158
has only substance units: false
boundary condition: true
name: PDE6A:PDE6H:PDE6B
constant: false
is encoded by: hsa:5149
type: Species
is: SBO:0000297
has part: Q13956
has part: P16499
initial amount: NaN

metaM prostgi2 e
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01335
is: SBO:0000247
name: prostaglandin I2(1-)
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403

http://identifiers.org/biomodels.db/MODEL1310110060#_052184b5_025d_4ac5_8e14_a6eb7093bef0
is encoded by: hsa:4967
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000297
name: DLD:DLST:OGDH:PDHX
has part: B4E3E9

metaR r0464
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3

metaR r2334
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaR G3PD1
product: MODEL1310110060#
is described by: ECO:0000269
reactant: MODEL1310110060#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.8
fast: false
is: SBO:0000176
modifier: MODEL1310110060#
name: glycerol-3-phosphate dehydrogenase (NAD)
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2

metaM hmbil c
type: Species
is: C01024
is: HMDB01137
boundary condition: false
is: CHEBI:57845
initial amount: NaN
initial concentration: 1.0
name: Hydroxymethylbilane
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024

metaM udp l
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00295
is: SBO:0000247
is: CHEBI:58223
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)

metaM pchol hs c
is: HMDB02704
is: CHEBI:21338
has only substance units: false
name: pchol_hs[c]
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_25ec5a83_0a3e_4c01_bbec_2d5cd61d5f4a
is: SBO:0000252
has only substance units: false
name: ST3GAL1
type: Species
initial concentration: NaN
is encoded by: hsa:6482
boundary condition: true
constant: false
initial amount: NaN

metaR S6TASE15ly
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
modifier: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_15619c5e_93f2_424f_9146_bf6160ded53c
is: SBO:0000252
is encoded by: hsa:BF195998
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: _BF195998_1_x
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_0fdebb9e_3d8c_4ea4_9b4a_a5d972cd1e41
initial amount: NaN
is: O14734
is: SBO:0000252
type: Species
has only substance units: false
name: ACOT8
constant: false
initial concentration: NaN
is encoded by: hsa:10005
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_9808174a_727a_49a1_9dae_a41a1a00152c
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4245
name: MGAT1
is: P26572
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaM CE1617 r
initial concentration: 1.0
initial amount: NaN
constant: false
name: 9-cis-retinoate
is: CHEBI:17898
type: Species
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
is: SBO:0000247
has only substance units: false
is: HMDB01358

http://identifiers.org/biomodels.db/MODEL1310110060#_f2e24a22_386e_45d5_bc81_1a19c6a759b9
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:29085
is: Q9P019
initial amount: NaN
name: PHPT1
is: SBO:0000252

metaR r2109
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM omhpal r
boundary condition: false
initial amount: NaN
type: Species
name: w-hydroxypalmiticacid
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB06294
notes: FORMULA: C16H30O3 CHARGE: -1

metaM 5adtststerone c
initial amount: NaN
is: CHEBI:16330
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
constant: false
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR DURAD
reactant: MODEL1310110060#
name: dihydrouracil dehydrogenase (NADP)
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110060#
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

metaR r0463
fast: false
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_800cbc88_3a36_46d4_9e2f_8deb24afe9ed
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3032
name: HADHB
is: P55084
is: SBO:0000252
type: Species

metaR Ser Thrtg
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
name: Ser/Thr transport (from golgi to lysosome)
type: Reaction
product: MODEL1310110060#
is: SBO:0000185

metaR r1669
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction

metaM crm hs c
name: N-acylsphingosine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:52639

http://identifiers.org/biomodels.db/MODEL1310110060#_b93b23cf_0653_4dfd_98ca_4c686a4c2234
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: ESD
is: P10768
is encoded by: hsa:2098
has only substance units: false

metaM ura e
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
initial concentration: 1.0
is: CHEBI:17568
has only substance units: false
name: uracil
type: Species
initial amount: NaN

metaM cyan c
initial concentration: 1.0
is: CHEBI:18407
name: hydrogen cyanide
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
is: HMDB02084
initial amount: NaN
is: SBO:0000247

metaM ksi pre13 g
is: CHEBI:58053
has only substance units: false
initial amount: NaN
is: C00130
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 13
is: HMDB00175
constant: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaM dopa e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00073
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: SBO:0000247
type: Species
constant: false
is: CHEBI:59905
has only substance units: false

metaM meoh l
is: CHEBI:17790
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01875
constant: false
type: Species
name: methanol
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: SBO:0000247

metaR 2HBO
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_ed7d7269_c86c_44a4_aa50_d2eb7c7b0dfb
name: COX6A1
is: SBO:0000252
boundary condition: true
is: P12074
has only substance units: false
initial amount: NaN
is encoded by: hsa:1337
type: Species
constant: false
initial concentration: NaN

metaR H2Otp
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: H2O transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r2108
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_c267858a_2e72_42d6_9a4d_44367508f771
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: _AA081045_1_e
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA081045
initial amount: NaN

metaM glyald m
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:17378
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
has only substance units: false
name: D-glyceraldehyde
is: SBO:0000247
type: Species
is: HMDB01051
initial concentration: 1.0

metaR AG13T10g
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110060#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_8777bd39_61f0_44b2_bff3_21d66294d68d
is encoded by: hsa:57171
is: SBO:0000252
initial amount: NaN
name: DOLPP1
constant: false
initial concentration: NaN
is: Q86YN1
type: Species
boundary condition: true
has only substance units: false

metaM tymsf e
initial amount: NaN
constant: false
name: Tyramine O-sulfate
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB06409

metaM occoa x
has only substance units: false
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
is: CHEBI:57386
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
is: SBO:0000247
is: C01944
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_1904c322_64e0_4eaa_b32c_d4534a35cf35
is encoded by: hsa:51727
initial amount: NaN
type: Species
constant: false
name: CMPK1
is: B2R6S5
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r1668
modifier: MODEL1310110060#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_70bc9198_0d44_4a4d_b60f_7ef5b4df5343
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: TPI1P2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:286016

metaR r2332
fast: false
product: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_88bfdc8b_40e9_4cb3_b37a_e1543702bd5f
initial concentration: NaN
boundary condition: true
name: SLC24A3
type: Species
is encoded by: hsa:57419
has only substance units: false
is: SBO:0000252
is: Q9HC58
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_f34ef71c_f707_4265_90d8_4e06e1fa5228
type: Species
boundary condition: true
is: Q9NRA0
is encoded by: hsa:56848
has only substance units: false
initial concentration: NaN
name: SPHK2
initial amount: NaN
constant: false
is: SBO:0000252

metaM 1pyr5c m
initial concentration: 1.0
boundary condition: false
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
is: CHEBI:15893
constant: false
has only substance units: false
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: HMDB01301
initial amount: NaN
is: C03912

metaM C02470 c
initial concentration: 1.0
constant: false
is: SBO:0000247
name: Xanthurenic acid
is: HMDB00881
has only substance units: false
is: http://identifiers.org/pubchem.compound/5485
initial amount: NaN
is: C02470
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
type: Species
boundary condition: false

metaM udp n
initial concentration: 1.0
is: HMDB00295
boundary condition: false
constant: false
is: CHEBI:58223
type: Species
is: SBO:0000247
name: UDP(3-)
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_e55b2633_0980_4465_8aaf_98acefd98894
type: Species
is encoded by: hsa:6240
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P23921
name: RRM1

metaR ADEt
type: Reaction
name: adenine reversible transport, cytosol
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
is: SBO:0000185
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269
reversible: true

metaR SGPL12r
is: SBO:0000176
name: Sphingosine-1-phosphate lyase
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000304

metaR RE1520M
reactant: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is: SBO:0000176
name: RE1520
type: Reaction
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM dctp c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: C00458
type: Species
name: dCTP
is: CHEBI:16311
is: HMDB00998
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458

http://identifiers.org/biomodels.db/MODEL1310110060#_8778ff11_76c8_413e_9ac5_429b306b1c00
constant: false
boundary condition: true
has only substance units: false
is: A8K7W0
is encoded by: hsa:8875
initial concentration: NaN
name: VNN2
initial amount: NaN
is: SBO:0000252
type: Species

metaR LEUKTRF4t
type: Reaction
is: SBO:0000185
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: leukotriene F4 transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR ALR3
name: aldose reductase (acetol)
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269
reversible: false

metaR r2107
reactant: MODEL1310110060#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_88eeefbb_cd84_434c_9670_0bb74f9af883
type: Species
name: NDUFV1
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4723
is: E5KNH5

metaR H2Otm
type: Reaction
reversible: true
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
name: H2O transport, mitochondrial
fast: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269

metaM m2mn l
initial amount: NaN
is: HMDB06537
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
initial concentration: 1.0

metaR r2333
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110060#
reversible: true
type: Reaction

metaM sphmyln hs c
constant: false
is: HMDB02704
notes: FORMULA: CHARGE: 0
name: sphmyln_hs[c]
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:21338

metaR r1667
is: SBO:0000185
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
modifier: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaR UGLT
is: SBO:0000176
name: UDPglucose--hexose-1-phosphate uridylyltransferase
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.7.12
reversible: true

metaM cyan e
is: CHEBI:18407
initial concentration: 1.0
constant: false
boundary condition: false
name: hydrogen cyanide
has only substance units: false
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
is: HMDB02084
is: SBO:0000247

metaR M1316Mg
is version of: http://identifiers.org/ec-code/3.2.1.114
reversible: false
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
product: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_3e5a0bec_2b82_46a3_b7c8_2926ae311131
initial concentration: NaN
name: PCBD1
initial amount: NaN
is encoded by: hsa:5092
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_2bd78bbe_3e60_4905_9ee0_2ae011a99cdf
boundary condition: true
initial concentration: NaN
has part: O95497
is encoded by: hsa:55350
initial amount: NaN
is encoded by: hsa:8875
has part: A8K7W0
has only substance units: false
type: Species
name: VNN3:VNN2:VNN1
is encoded by: hsa:8876
is: SBO:0000297
constant: false

metaR GALASE13ly
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_f9e70472_e7dd_4e88_a100_b5adbcd113f8
type: Species
has only substance units: false
boundary condition: true
is: Q96E98
constant: false
initial amount: NaN
name: RHAG
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6005

http://identifiers.org/biomodels.db/MODEL1310110060#_11f9683c_b4b7_4006_86fa_2a80789cbbd6
is: SBO:0000252
name: _H17063_1_c
is encoded by: hsa:H17063
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_596a6d8f_4e5f_47d2_87b8_fa8fff4e0baf
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9H3H5
type: Species
has only substance units: false
name: DPAGT1
boundary condition: true
is encoded by: hsa:1798
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_067c5911_de42_4028_960e_ab22ecf73689
has only substance units: false
is encoded by: hsa:2629
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: GBA
boundary condition: true
initial concentration: NaN

metaR r2106
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110060#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_cacf3fbe_cc0d_4eaf_b207_9fc9c0a3cbe3
name: PDE7B
initial amount: NaN
is: Q9NP56
boundary condition: true
is encoded by: hsa:27115
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_1e8b9bbd_0306_47cb_bf1b_f69832fe2df1
is: P35557
initial amount: NaN
constant: false
is encoded by: hsa:2645
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: GCK

metaR H2Otn
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reversible: true
type: Reaction
name: H2O transport, nuclear
is described by: ECO:0000000
is: SBO:0000185

metaM hs deg7 l
is: HMDB01352
boundary condition: false
initial concentration: 1.0
is: CHEBI:17180
has only substance units: false
name: heparan sulfate, degradation product 7
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaR ALAR
fast: false
name: alanine racemase
type: Reaction
is described by: ECO:0000212
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
modifier: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true

metaR PDE4
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.35
product: MODEL1310110060#
is: SBO:0000176
name: 3',5'-cyclic-nucleotide phosphodiesterase
is described by: ECO:0000269
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
modifier: MODEL1310110060#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.17

metaR CYTK14
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110060#
reactant: MODEL1310110060#
name: cytidylate kinase (dCMP,UTP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaM hLkynr c
constant: false
initial amount: NaN
name: 3-hydroxy-L-kynurenine
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: HMDB11631
type: Species
is: CHEBI:17380

metaR r2330
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true

metaR NDPK1m
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
reactant: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM srtn c
boundary condition: false
name: serotonin(1+)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00259
has only substance units: false
is: CHEBI:350546
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species

metaM lys L c
is: HMDB00182
name: L-lysinium(1+)
initial concentration: 1.0
boundary condition: false
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000247

metaR G14T7g
reversible: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_16354a55_49e9_418c_bba2_fc4df06f39bb
is encoded by: hsa:6647
is: SBO:0000252
constant: false
boundary condition: true
is: P00441
has only substance units: false
name: SOD1
initial concentration: NaN
initial amount: NaN
type: Species

metaR FRUt4
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
name: D-fructose transport via sodium cotransport
fast: false
type: Reaction
reversible: true

metaM hdca e
initial amount: NaN
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
is: HMDB00220
is: C00249
has only substance units: false
is: CHEBI:0
notes: FORMULA: C16H31O2 CHARGE: -1
type: Species
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_e9c935cb_4fd3_41fb_973b_0f54b7ac7fc5
name: PAPSS1
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9061
initial amount: NaN
is: O43252
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_c1e6ac3a_83b0_4401_a74e_95ee567ba411
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: DDOST
is encoded by: hsa:1650
has only substance units: false
constant: false
is: P39656

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110060#
fast: false

metaM spc hs c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5311445
type: Species
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial amount: NaN
has only substance units: false
name: sphingosylphosphorylcholine
constant: false
boundary condition: false
initial concentration: 1.0

metaR AG13T8g
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_53147097_a3b4_4b56_a9ed_fbff3744964f
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q99798
initial amount: NaN
type: Species
is encoded by: hsa:50
has only substance units: false
constant: false
name: ACO2

http://identifiers.org/biomodels.db/MODEL1310110060#_ecdf3067_3d06_4a6e_851f_be58b3f834cf
has only substance units: false
type: Species
name: FADS1
boundary condition: true
constant: false
is encoded by: hsa:3992
initial concentration: NaN
is: O60427
initial amount: NaN
is: SBO:0000252

metaR r2331
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
type: Reaction

metaM crm hs g
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
is: CHEBI:52639
initial amount: NaN
boundary condition: false
name: N-acylsphingosine
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaR ME2m
is version of: http://identifiers.org/ec-code/1.1.1.38
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.40
name: malic enzyme (NADP), mitochondrial
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
fast: false
product: MODEL1310110060#
is: SBO:0000176

metaM ptth m
is: HMDB03426
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_2b8a7416_c791_4a93_b54a_dc1b1fce9dee
is encoded by: hsa:26
constant: false
name: ABP1
has only substance units: false
is: P19801
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaM malt e
is: C00208
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
has only substance units: false
boundary condition: false
is: HMDB00163
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:17306
type: Species
constant: false
name: Maltose

http://identifiers.org/biomodels.db/MODEL1310110060#_3aba8781_8ab4_4406_99a5_04fad45f6b2d
type: Species
is: SBO:0000252
name: HAO2
is: Q9NYQ3
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:51179
boundary condition: true

metaR r1559
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110060#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction

metaM CE5236 c
name: O2'-4a-cyclic-tetrahydrobiopterin
type: Species
has only substance units: false
is: CHEBI:28002
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: HMDB03952
is: SBO:0000247
initial concentration: 1.0

metaM srtn e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: HMDB00259
constant: false
boundary condition: false
name: serotonin(1+)
has only substance units: false
type: Species
is: CHEBI:350546

metaM xol7ah c
is: HMDB06892
has only substance units: false
is: CHEBI:2290
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
name: 7alpha-hydroxy-5beta-cholestan-3-one
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247

metaM gluala e
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6503
is: C03740
constant: false
is: HMDB06248
initial amount: NaN
name: 5-L-Glutamyl-L-alanine
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_452fbc97_7329_4a5f_9c3f_2bfa8f6b51cb
type: Species
is: SBO:0000252
initial amount: NaN
name: NME2
is encoded by: hsa:4831
has only substance units: false
is: P22392
initial concentration: NaN
boundary condition: true
constant: false

metaM malcoa r
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01175
boundary condition: false
is: CHEBI:57384
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
name: malonyl-CoA(4-)
initial amount: NaN
constant: false
has only substance units: false

metaR URATEt
reversible: false
name: urate export from cytosol
product: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110060#
type: Reaction

metaR LEUKTRB4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene B4 transport
reversible: true
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_fe4c878b_8d87_402d_895a_0ca02867fa12
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:83549
name: UCK1
type: Species
is: Q5JT09
boundary condition: true
initial amount: NaN

metaR r0579
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.13.11.19
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaR GGNG
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.11
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.186
notes: GENE_ASSOCIATION: (8908.1) and (2998.1) or (2998.1) and (2992.1) or (2997.1) and (2992.1) or (8908.1) and (2997.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15238248,PMID:8602861,PMID:9857012 NOTES:NCD
modifier: MODEL1310110060#
name: glycogenin self-glucosylation
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110060#
product: MODEL1310110060#

metaM ksi deg9 l
is: CHEBI:12936
initial amount: NaN
has only substance units: false
is: HMDB00143
name: keratan sulfate I, degradation product 9
constant: false
boundary condition: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR MDHm
reversible: true
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.37
kinetic law: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
name: malate dehydrogenase, mitochondrial
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_38341cb0_84e1_43ec_b1e1_060c408a3ff1
name: PRDX2
constant: false
initial amount: NaN
type: Species
is: P32119
initial concentration: NaN
is encoded by: hsa:7001
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR CYTK12
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110060#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dCTP)

metaM prostgi2 c
initial concentration: 1.0
is: CHEBI:57403
has only substance units: false
name: prostaglandin I2(1-)
constant: false
is: HMDB01335
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN
boundary condition: false

metaM 34dhpac c
initial amount: NaN
is: HMDB03791
boundary condition: false
has only substance units: false
name: 3,4-Dihydroxyphenylacetaldehyde
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
initial concentration: 1.0
is: CHEBI:27978

http://identifiers.org/biomodels.db/MODEL1310110060#_150c39e3_2786_4c32_acaa_4077a6222d8a
has only substance units: false
is: Q86T14
name: GMPR2
is encoded by: hsa:51292
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_12ada6ab_c41a_48f6_977f_dcec0edb5e53
constant: false
boundary condition: true
type: Species
is: P16066
initial amount: NaN
is encoded by: hsa:4881
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NPR1

http://identifiers.org/biomodels.db/MODEL1310110060#_280545b9_0119_4792_8fd1_9fda6f158019
boundary condition: true
is: Q9HAS3
constant: false
name: SLC28A3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:64078
initial amount: NaN
initial concentration: NaN
type: Species

metaM odecoa c
is: CHEBI:3793
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01322
name: Octadecenoyl-CoA (n-C18:1CoA)
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM dolmanp U c
name: Dolichyl phosphate D-mannose, human uterine homolog
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:15809
initial amount: NaN

metaM 5adtststerone e
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
is: HMDB02961

http://identifiers.org/biomodels.db/MODEL1310110060#_21ab0bc2_fe50_4764_88e7_d2f2a1b1fa91
is: P05187
is: SBO:0000252
name: ALPP
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:250
type: Species
has only substance units: false

metaM udp r
is: CHEBI:58223
constant: false
is: C00015
name: UDP
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00295

metaR RE1810M
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176
name: RE1810
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reversible: true

metaR PDE1
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is: SBO:0000176
type: Reaction
product: MODEL1310110060#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.17
fast: false
name: 3',5'-cyclic-nucleotide phosphodiesterase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.35
reactant: MODEL1310110060#

metaM hdca c
constant: false
is: SBO:0000247
name: palmitate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false
is: HMDB00220
boundary condition: false
type: Species
is: CHEBI:7896

metaR CYTK13
modifier: MODEL1310110060#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP)
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000176
product: MODEL1310110060#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110060#

metaM spc hs e
is: http://identifiers.org/pubchem.compound/5311445
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: sphingosylphosphorylcholine
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
type: Species
initial concentration: 1.0

metaR r0578
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction

metaM ura c
initial amount: NaN
is: C00106
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
name: Uracil
is: HMDB00300
is: CHEBI:17568
is: SBO:0000247
boundary condition: false

metaM glyb e
initial amount: NaN
boundary condition: false
is: HMDB00043
type: Species
name: glycine betaine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
has only substance units: false
is: SBO:0000247
is: CHEBI:17750
initial concentration: 1.0
constant: false

metaM malt c
is: C00208
is: CHEBI:17306
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
type: Species
initial concentration: 1.0
is: HMDB00163
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: Maltose

http://identifiers.org/biomodels.db/MODEL1310110060#_eb706c10_100f_43e6_beaf_efc486296bc0
initial concentration: NaN
is encoded by: hsa:79087
is: SBO:0000252
name: ALG12
constant: false
has only substance units: false
type: Species
boundary condition: true
is: Q9BV10
initial amount: NaN

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR RPE
is version of: http://identifiers.org/ec-code/5.1.3.1
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
name: ribulose 5-phosphate 3-epimerase
reversible: true
modifier: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#

metaM crm hs e
is: CHEBI:52639
boundary condition: false
name: N-acylsphingosine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
has only substance units: false
constant: false

metaR MALSO3tm
reactant: MODEL1310110060#
product: MODEL1310110060#
name: Malate:sulfite antiport, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000269

metaM pep c
is: C00074
type: Species
constant: false
is: CHEBI:18021
name: Phosphoenolpyruvate
has only substance units: false
is: HMDB00263
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074

metaR ASCBt
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
name: L-ascorbate transport via facilitated diffusion
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110060#_5d08d5a7_8bf5_4616_88d7_7ea1126901c9
type: Species
is: SBO:0000252
is: Q16222
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: UAP1
is encoded by: hsa:6675
initial concentration: NaN

metaR ALADGLYexR
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
name: D-alanine/glycine reversible exchange
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000304
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_fe65de39_a006_4de0_96db_78bf178569f1
type: Species
initial concentration: NaN
boundary condition: true
name: PCBD1
initial amount: NaN
is: P61457
has only substance units: false
is encoded by: hsa:5092
constant: false
is: SBO:0000252

metaM ksi pre16 g
constant: false
name: keratan sulfate I biosynthesis, precursor 16
is: C00130
is: HMDB00175
type: Species
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:58053

metaM amet m
name: S-Adenosyl-L-methionine
constant: false
has only substance units: false
is: C00019
is: CHEBI:15414
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
boundary condition: false
is: HMDB01185
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_e7539996_cfc9_4c3e_9dee_fb88ae01e27a
initial amount: NaN
is encoded by: hsa:2954
is: O43708
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GSTZ1
constant: false
initial concentration: NaN

metaR r2100
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110060#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_3d0da74d_f2eb_4867_b335_1df61e783d51
constant: false
initial amount: NaN
is: SBO:0000252
name: PYGM
boundary condition: true
has only substance units: false
is encoded by: hsa:5837
type: Species
initial concentration: NaN
is: P11217

metaM dctp n
is: HMDB00998
is: CHEBI:16311
has only substance units: false
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00458
is: SBO:0000247
type: Species
boundary condition: false

metaR SO4t4 2
name: sulfate transport via sodium symport
type: Reaction
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
reversible: true
reactant: MODEL1310110060#
is described by: ECO:0000269
fast: false
product: MODEL1310110060#
is: SBO:0000185
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_2a1653e7_4754_4f37_9d3d_64975a54926e
is encoded by: hsa:50808
constant: false
is: E7ET30
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: AK3
initial concentration: NaN
has only substance units: false

metaM cholate c
initial concentration: 1.0
type: Species
is: HMDB00619
is: CHEBI:29747
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: Cholate
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695

metaM cl c
type: Species
is: HMDB00492
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:3966
initial concentration: 1.0
is: C00115
name: Chloride
constant: false
has only substance units: false
notes: FORMULA: Cl CHARGE: -1

metaM occoa m
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
is: SBO:0000247
is: C01944
initial amount: NaN
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
is: CHEBI:57386
is: HMDB01070
type: Species
constant: false

metaR FACOAL160i
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is: SBO:0000176
name: C160 fatty acid activation
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
reversible: false

metaM lnlnca r
type: Species
name: alpha-linolenate
initial amount: NaN
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: HMDB01388
is: CHEBI:32387
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM pchol hs m
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16110
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR PPItr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
reactant: MODEL1310110060#
fast: false
is: SBO:0000185
product: MODEL1310110060#
reversible: true
name: Diphosphate transporter, endoplasmic reticulum
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaM fe3 c
has only substance units: false
constant: false
is: HMDB12943
name: Fe3+
notes: FORMULA: Fe CHARGE: 3
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_e900a871_4477_4d3b_910f_8c84d3cb1449
is: SBO:0000252
constant: false
type: Species
name: _AL525798_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AL525798

metaR GTHDH
product: MODEL1310110060#
fast: false
type: Reaction
name: Glutathione dehydrogenase (dehydroascorbate reductase)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
kinetic law: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000134
reversible: false

metaR r1177
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110060#
name: EC:3.1.1.13
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: false
fast: false

metaR NADtpu
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
reversible: false
is: SBO:0000185
fast: false
name: NAD transporter, peroxisome
product: MODEL1310110060#

metaM acgam1p c
constant: false
boundary condition: false
is: HMDB01367
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
is: CHEBI:7125
name: N-Acetyl-D-glucosamine 1-phosphate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_1189792f_9e39_4799_be0e_192a71a6d6ab
initial amount: NaN
initial concentration: NaN
name: SLC25A1
constant: false
is encoded by: hsa:6576
type: Species
boundary condition: true
is: D9HTE9
has only substance units: false
is: SBO:0000252

metaM gluside hs c
boundary condition: false
is: CHEBI:18368
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
type: Species
constant: false
is: SBO:0000247

metaR CYTK11
fast: false
reactant: MODEL1310110060#
name: cytidylate kinase (dCMP,dGTP)
product: MODEL1310110060#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true

metaM man l
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-mannose
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00169
boundary condition: false
is: CHEBI:16024
initial amount: NaN

metaM prpncoa m
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
name: acryloyl-CoA(4-)
is: HMDB02307
is: CHEBI:57367
type: Species
boundary condition: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894

http://identifiers.org/biomodels.db/MODEL1310110060#_00222618_1183_4b4a_a329_b726007ac385
constant: false
is: Q11203
type: Species
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r2101
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110060#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110060#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction

metaR CYTK9n
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
modifier: MODEL1310110060#
name: cytidylate kinase (CMP,dCTP),nuclear
reversible: true
fast: false

metaM q10 m
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
type: Species
is: HMDB01072
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:46245
name: ubiquinone-10

metaR FRDPtcr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
type: Reaction
is: SBO:0000185
product: MODEL1310110060#
is described by: ECO:0000134
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
name: transport of Farnesyl diphosphate into the endoplasmic reticulum

metaM dcyt e
is: C00881
name: Deoxycytidine
initial concentration: 1.0
is: HMDB00014
boundary condition: false
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:15698
constant: false

metaR CYTK10n
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110060#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000176
name: cytidylate kinase (CMP,dGTP),nuclear
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_bc80cf74_2802_4d61_9028_bfe692a3596a
name: B3GNTL1
is: Q67FW5
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:146712
type: Species
initial amount: NaN

metaR UDPGLCter
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: true
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
fast: false
product: MODEL1310110060#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport

metaR HSAT3ly
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110060#

metaR FACOAL80i
modifier: MODEL1310110060#
fast: false
name: fatty-acid--CoA ligase (octanoate)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
type: Reaction
reversible: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaR CYTK10
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dGTP)
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_dbc170e6_77a5_4edf_9c89_350a46e179ed
is encoded by: hsa:10201
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: O75414
has only substance units: false
is: SBO:0000252
name: NME6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_f79af1f9_9956_479f_8219_c22eba2b08b6
has only substance units: false
boundary condition: true
name: SULT1A3
type: Species
is: Q1ET61
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6818
initial concentration: NaN
constant: false

metaR SMPD4
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
kinetic law: MODEL1310110060#
is: SBO:0000176
name: sphingomyelinase
is described by: ECO:0000000
reversible: false
product: MODEL1310110060#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f7c621cf_b7ac_4d68_9f45_bba8de0fa0fd
is encoded by: hsa:AI291895
type: Species
name: _AI291895_1_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM fe3 e
is: HMDB12943
is: CHEBI:29034
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
has only substance units: false
name: Fe3+
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_d4deeb3d_8490_44b3_8c5c_43d32b540628
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2876
is: P07203
constant: false
name: GPX1
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_b49aea8e_8ee7_4a73_86cf_fbb824f13ba3
is encoded by: hsa:8395
constant: false
initial concentration: NaN
is: O14986
is: SBO:0000252
type: Species
name: PIP5K1B
has only substance units: false
initial amount: NaN
boundary condition: true

metaM cholate e
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
is: HMDB00619
initial concentration: 1.0
type: Species
is: CHEBI:29747
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

metaM h x
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
is: C00080
name: proton
constant: false
is: CHEBI:24636
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
type: Species
has only substance units: false

metaR D3AIBTm
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
type: Reaction
reversible: true
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110060#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
kinetic law: MODEL1310110060#

metaM pd3 c
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial amount: NaN
type: Species
name: Previtamin D3
is: HMDB06500
initial concentration: 1.0

metaM pppg9 c
has only substance units: false
name: Protoporphyrinogen IX
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01097
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
is: C01079
is: CHEBI:57307

metaR NDPK1n
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
fast: false
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_5cf1488d_f7b7_4b0f_8463_581f51387631
type: Species
boundary condition: true
is encoded by: hsa:M68895
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: _M68895_1_c

metaM L2aadp c
is: SBO:0000247
initial amount: NaN
is: CHEBI:58672
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: L-2-aminoadipate(1-)
is: HMDB00510
has only substance units: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaR ADNCYC
reactant: MODEL1310110060#
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.6.1.1
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
name: adenylate cyclase
is described by: ECO:0000269
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false

metaR RPI
reversible: true
fast: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/5.3.1.6
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
is: SBO:0000176
name: ribose-5-phosphate isomerase

http://identifiers.org/biomodels.db/MODEL1310110060#_dde9e985_1473_4600_b98c_596c981bbc2e
initial concentration: NaN
type: Species
has only substance units: false
name: CHAT
is: D3DX95
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1103

metaR r2193
kinetic law: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110060#
reactant: MODEL1310110060#

metaR r0717
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_24523950_c497_4ed0_bcc6_fe13f2962a47
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:57786
is: Q9NYW8
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: RBAK

metaM chsterol l
initial concentration: 1.0
has only substance units: false
name: cholesterol
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
type: Species
is: CHEBI:16113
constant: false
initial amount: NaN
is: HMDB00067

metaR UPP3S
product: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.75
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
type: Reaction
name: uroporphyrinogen-III synthase
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_ae0b6027_06e4_4818_8359_f616c4883737
constant: false
is encoded by: hsa:219
is: P30837
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: ALDH1B1
initial concentration: NaN
is: SBO:0000252

metaM Ser Thr g
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: XH CHARGE: 0
type: Species
is: CHEBI:58336
has only substance units: false
is: HMDB00645
initial amount: NaN
initial concentration: 1.0

metaR RE1342C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
name: RE1342
fast: false

metaM dcyt c
name: Deoxycytidine
initial concentration: 1.0
is: C00881
boundary condition: false
is: HMDB00014
has only substance units: false
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
initial amount: NaN
is: CHEBI:15698
constant: false

metaM etoh c
name: ethanol
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:16236
is: HMDB00108

metaR r0345
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110060#

metaR r0680
modifier: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.137
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaM CE5788 e
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:27485
is: HMDB02710
name: kinetensin 1-7
has only substance units: false

metaM ksi pre34 g
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
is: HMDB00175
is: C00130
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 34
has only substance units: false
boundary condition: false

metaR r0068
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
kinetic law: MODEL1310110060#
type: Reaction
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
is described by: ECO:0000000
modifier: MODEL1310110060#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.1
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR RE1530C
name: RE1530
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reversible: true
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110060#

metaM chsterol m
initial amount: NaN
name: cholesterol
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00067
is: CHEBI:16113
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaR r0716
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reactant: MODEL1310110060#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110060#

metaR r0603
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110060#
modifier: MODEL1310110060#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.12
type: Reaction
reversible: true
kinetic law: MODEL1310110060#

metaM 34dhmald c
boundary condition: false
constant: false
name: 3,4-Dihydroxymandelaldehyde
is: HMDB06242
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
initial concentration: 1.0
initial amount: NaN
is: C05577
is: http://identifiers.org/pubchem.compound/7903
is: SBO:0000247
has only substance units: false
type: Species

metaR r0817
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
modifier: MODEL1310110060#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r2104
type: Reaction
fast: false
modifier: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR ALAt2r
kinetic law: MODEL1310110060#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
product: MODEL1310110060#
name: L-alanine reversible transport via proton symport
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is: SBO:0000185

metaM 3dhguln c
name: 3-dehydro-L-gulonate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: HMDB06334
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57655
type: Species

metaR S6TASE17ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#
type: Reaction

metaR SPC HSt
reactant: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
fast: false
name: sphingosylphosphorylcholine transport (diffusion)
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is: SBO:0000185
product: MODEL1310110060#

metaR r2195
kinetic law: MODEL1310110060#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110060#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaM ksii core4 deg4 l
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01354
name: keratan sulfate II (core 4-linked), degradation product 4
type: Species
is: CHEBI:57455
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C66H108N6O48SX CHARGE: -1

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_917d318e_9876_45d6_979d_c181f174dcbe
is encoded by: hsa:10873
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: ME3
initial amount: NaN
initial concentration: NaN
is: Q6TCH8
constant: false

metaM dtmp e
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: SBO:0000247
is: HMDB01227
initial amount: NaN
is: CHEBI:26999
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: dTMP(2-)

metaM cgly c
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00078
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
initial amount: NaN
initial concentration: 1.0
name: L-cysteinylglycine
is: CHEBI:4047

http://identifiers.org/biomodels.db/MODEL1310110060#_62270080_e4bb_4a79_b382_0f47007411b8
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: HSD3B1
is: P14060
is encoded by: hsa:3283
has only substance units: false

metaR r0276
type: Reaction
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110060#
is: SBO:0000176
reversible: true
fast: false

metaR S3TASE3ly
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaR FAOXC180
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#
type: Reaction
name: Beta oxidation of long chain fatty acid

metaM fru c
is: C00095
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15824
name: D-Fructose
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
constant: false
type: Species
is: HMDB00660

metaM acnamp c
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:27438
initial amount: NaN
is: HMDB06268
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
initial concentration: 1.0
name: N-Acetylneuraminate 9-phosphate
constant: false
has only substance units: false

metaM etoh e
initial concentration: 1.0
has only substance units: false
name: ethanol
boundary condition: false
initial amount: NaN
is: HMDB00108
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16236

metaR r1172
reversible: false
kinetic law: MODEL1310110060#
fast: false
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: EC:3.1.1.13
product: MODEL1310110060#

metaM pyr x
is: C00022
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
constant: false
is: CHEBI:15361
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate

metaM 44mctr r
is: CHEBI:17813
initial concentration: 1.0
is: HMDB01023
boundary condition: false
has only substance units: false
constant: false
type: Species
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: SBO:0000247

metaR r2105
reversible: true
reactant: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false
product: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR AKR1D2
is version of: http://identifiers.org/ec-code/1.3.1.3
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is described by: ECO:0000269
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
modifier: MODEL1310110060#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000176

metaM pheme c
is: CHEBI:17627
is: HMDB03178
constant: false
type: Species
is: SBO:0000247
name: Protoheme
initial concentration: 1.0
is: C00032
boundary condition: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
has only substance units: false
initial amount: NaN

metaR DNDPt14m
reversible: false
is: SBO:0000185
product: MODEL1310110060#
type: Reaction
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
name: dUDP transport via dTDP antiport

metaR RE1573M
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110060#
is: SBO:0000176
name: RE1573

metaR r2194
type: Reaction
product: MODEL1310110060#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM dgsn c
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial amount: NaN
initial concentration: 1.0
is: C00330
constant: false
type: Species
has only substance units: false
is: CHEBI:17172
is: SBO:0000247
boundary condition: false
is: HMDB00085

metaR G12MT1 U
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_d94503d3_1510_4978_9df9_319a96862242
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6390
is: P21912
constant: false
is: SBO:0000252
type: Species
name: SDHB

metaM datp c
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
is: HMDB01532
is: C00131
type: Species
name: dATP
boundary condition: false
initial concentration: 1.0
is: CHEBI:61404

metaM HC00718 c
type: Species
initial concentration: 1.0
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: SBO:0000247
constant: false
has only substance units: false
name: N-methylethanolaminium phosphate(1-)
initial amount: NaN
is: CHEBI:57781
boundary condition: false

metaM man g
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: D-mannose
is: CHEBI:16024
is: HMDB00169
boundary condition: false

metaR r2338
fast: false
product: MODEL1310110060#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
kinetic law: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reactant: MODEL1310110060#
fast: false
type: Reaction
kinetic law: MODEL1310110060#

metaR SUCD1m
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110060#
type: Reaction
name: succinate dehydrogenase
is: SBO:0000176
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.5.1
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
modifier: MODEL1310110060#

metaR S26Tg
is version of: http://identifiers.org/ec-code/2.4.99.1
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (6480.1) or (6480.3) or (6480.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.99.1 Confidence Level: 0 AUTHORS: PMID:8027041 NOTES:NCD
type: Reaction
name: beta-galactoside alpha-2,6-sialyltransferase

metaM g3pc c
name: sn-Glycero-3-phosphocholine
has only substance units: false
is: CHEBI:16870
initial concentration: 1.0
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
is: HMDB00086
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR IDOURte
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110060#
is: SBO:0000185
reversible: true
type: Reaction
name: L-iduronate transport, extracellular
kinetic law: MODEL1310110060#

metaM zymstnl r
is: SBO:0000247
boundary condition: false
is: CHEBI:16608
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB06841
name: 5alpha-cholest-8-en-3beta-ol
has only substance units: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845

metaM dolp U c
boundary condition: false
is: CHEBI:57683
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
is: SBO:0000247
type: Species

metaR SPHS1Pte
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
reversible: true
name: sphingosine-1-phosphate transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaM hdca l
name: palmitate
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00220
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896

metaM hs deg18 l
name: heparan sulfate, degradation product 18
is: HMDB01352
has only substance units: false
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17180

metaR RPEc
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000176
name: ribulose 5-phosphate 3-epimerase
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reversible: true

metaM tymsf c
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
name: Tyramine O-sulfate
boundary condition: false
is: HMDB06409
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_9f6a45d2_4fc8_4775_98fc_b2479c6e7eaf
is encoded by: hsa:6817
type: Species
name: SULT1A1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaM CE5118 m
type: Species
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
initial amount: NaN
is: CHEBI:12947
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_26efe919_57b7_4426_9809_5eeaf488129a
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2629
name: GBA
type: Species
is: P04062
constant: false
has only substance units: false
initial amount: NaN

metaM pmtcoa c
is: C00154
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
initial concentration: 1.0
is: CHEBI:3454
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4

metaR r2197
modifier: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true

metaM Ser Thr l
constant: false
is: CHEBI:58190
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
type: Species
name: protein-linked serine or threonine residue (O-glycosylation site)
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00224

metaR CO2tp
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
name: CO2 peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110060#_fae52765_302d_4448_875a_9643bd034509
is: O00217
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NDUFS8
has only substance units: false
constant: false
is encoded by: hsa:4728
type: Species

metaR r2102
is: SBO:0000185
type: Reaction
modifier: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_f6a792d3_84b2_4a40_b9d6_2f4fb4b00133
initial concentration: NaN
is: Q13232
has only substance units: false
initial amount: NaN
name: NME3
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:4832

metaM cgly e
is: CHEBI:4047
initial amount: NaN
name: L-cysteinylglycine
constant: false
is: SBO:0000247
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: HMDB00078
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_d402a4b1_ebae_484d_99e2_34ed2895b9d9
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:220
has only substance units: false
is: P47895
name: ALDH1A3

metaM chsterol r
has only substance units: false
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16113

metaM glyb m
has only substance units: false
name: glycine betaine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
type: Species
is: SBO:0000247
is: CHEBI:17750

metaM fru e
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:15824
constant: false
initial concentration: 1.0
name: D-Fructose
is: HMDB00660
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: SBO:0000247
is: C00095

http://identifiers.org/biomodels.db/MODEL1310110060#_2684f6a9_deca_4e26_bb60_0724b0925df4
type: Species
boundary condition: true
is: Q8N5Z0
initial concentration: NaN
constant: false
is encoded by: hsa:51166
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: AADAT

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR r0340
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
fast: false
type: Reaction
is: SBO:0000176

metaR r0796
modifier: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
kinetic law: MODEL1310110060#
fast: false
type: Reaction
product: MODEL1310110060#

metaR r0683
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reversible: false
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110060#

metaM cl e
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00492
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
is: C00115
name: Chloride
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_090c441d_ccf9_4479_9b3a_2a3baae864d0
boundary condition: true
is: Q6UWQ5
initial amount: NaN
initial concentration: NaN
name: LYZL1
is encoded by: hsa:84569
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaR IDPtn
name: IDP nuclear transport
reversible: true
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110060#_ec082a31_b89d_41ec_9beb_73179fb3f8e3
constant: false
initial amount: NaN
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_m
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR SBTR
reactant: MODEL1310110060#
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
name: D-sorbitol reductase
fast: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
modifier: MODEL1310110060#

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110060#

metaM pheme e
is: SBO:0000247
type: Species
name: Protoheme
is: C00032
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: HMDB03178
has only substance units: false
is: CHEBI:17627
constant: false

metaR r2103
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR r0797
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
reversible: true
name: glycine N-choloyltransferase EC:2.3.1.65
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
fast: false

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM man e
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0
name: D-Mannose
type: Species
is: SBO:0000247
has only substance units: false
is: C00159
constant: false
initial amount: NaN
is: CHEBI:16024
boundary condition: false
is: HMDB00169

http://identifiers.org/biomodels.db/MODEL1310110060#_db508247_164f_414c_8983_cf05e98a74a4
type: Species
initial amount: NaN
name: RPN1
is encoded by: hsa:6184
constant: false
is: SBO:0000252
boundary condition: true
is: P04843
has only substance units: false
initial concentration: NaN

metaR r2196
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reactant: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_de06de22_cf93_4c91_8eb4_7234e9edf785
is: SBO:0000252
name: DGKE
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:8526
initial concentration: NaN
type: Species
has only substance units: false
is: A1L4Q0

http://identifiers.org/biomodels.db/MODEL1310110060#_da89401d_fe0b_46b4_8eb0_6365295d95c3
name: SGPL1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:8879
constant: false
is: O95470
initial amount: NaN
boundary condition: true

metaR NACHEX15ly
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
fast: false

metaR UMPK4n
is: SBO:0000176
fast: false
name: UMP kinase (GTP),nuclear
product: MODEL1310110060#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_4c4913c5_2bfd_4189_8889_84446b7b2b72
is: P21589
is encoded by: hsa:4907
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: NT5E

metaR r0812
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
is described by: ECO:0000000
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
type: Reaction

metaR DRPA
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
reversible: false
name: deoxyribose-phosphate aldolase
reactant: MODEL1310110060#

metaR S3TASE2ly
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110060#
name: N-acetylglucosamine-3-sulfatase, lysosomal
fast: false

metaR PIter
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000212
is: SBO:0000185
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
name: phosphate transport, endoplasmic reticulum
modifier: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_fd2c87f4_a31f_4acc_9879_2ce890f517df
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q5QPH3
is: SBO:0000252
name: ACSS2
boundary condition: true
is encoded by: hsa:55902
initial concentration: NaN

metaR NAGLCAly
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
name: N-acetylglucosaminidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
kinetic law: MODEL1310110060#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_161008d1_5795_4d60_8d89_304bdf12b63e
type: Species
name: SLC2A11
initial concentration: NaN
is encoded by: hsa:66035
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is: Q8WXF9

metaR GCCam
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
product: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110060#
reversible: true
is described by: ECO:0000269

metaM pppg9 m
initial amount: NaN
name: Protoporphyrinogen IX
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57307
is: HMDB01097
is: C01079
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079

metaR P4508B11r
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000269
reversible: false
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
is version of: http://identifiers.org/ec-code/1.14.13.95
modifier: MODEL1310110060#
fast: false
name: sterol 12-alpha-hydroxylase

http://identifiers.org/biomodels.db/MODEL1310110060#_19bfba5c_8072_4016_8d97_cdcb807fbeec
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: AGXT2
boundary condition: true
constant: false
is encoded by: hsa:64902
is: Q9BYV1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_e8d579e7_1281_4f7f_a69e_c18e239a62f5
boundary condition: true
constant: false
is encoded by: hsa:2582
name: GALE
is: SBO:0000252
initial amount: NaN
is: Q14376
initial concentration: NaN
has only substance units: false
type: Species

metaM dcyt n
initial concentration: 1.0
name: 2'-deoxycytidine
constant: false
is: HMDB00014
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
type: Species
is: CHEBI:15698
boundary condition: false
has only substance units: false
initial amount: NaN

metaM 4abut c
is: HMDB00112
is: SBO:0000247
is: CHEBI:3628
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
is: C00334
initial concentration: 1.0
name: 4-Aminobutanoate
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaM thymd c
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: CHEBI:17748
initial amount: NaN
is: SBO:0000247
is: C00214
type: Species
initial concentration: 1.0
name: Thymidine
is: HMDB00273
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_57c45927_02cc_4cc7_b9fc_93b06c8e946d
is: Q9P0J0
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: NDUFA13
is encoded by: hsa:51079
type: Species
has only substance units: false

metaM dtdp m
boundary condition: false
initial amount: NaN
is: HMDB01274
is: SBO:0000247
name: dTDP
has only substance units: false
type: Species
is: CHEBI:58369
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: C00363

http://identifiers.org/biomodels.db/MODEL1310110060#_26bc2b31_e718_47f9_9619_34416afb764d
name: SLC37A4
boundary condition: true
is encoded by: hsa:2542
initial amount: NaN
has only substance units: false
is: A8K0S7
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaM h n
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: proton
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

http://identifiers.org/biomodels.db/MODEL1310110060#_a0ca485c_5104_4222_972a_1dbaf7124406
boundary condition: true
is: Q96L53
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: ST3GAL3
is encoded by: hsa:6487
type: Species

metaM hdca r
constant: false
is: C00249
is: HMDB00220
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
is: CHEBI:7896
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
has only substance units: false

metaM pyr m
constant: false
is: HMDB00243
is: http://identifiers.org/pubchem.compound/3324
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false
name: pyruvate
is: C00022
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:15361
initial amount: NaN
is: SBO:0000247

metaR r0926
name: Postulated transport reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
product: MODEL1310110060#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000185
type: Reaction

metaM imp c
name: IMP
has only substance units: false
is: CHEBI:58053
is: C00130
constant: false
boundary condition: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00175
initial concentration: 1.0

metaR ALADGLNexR
reactant: MODEL1310110060#
is described by: ECO:0000304
fast: false
name: L-alanine/glutamine reversible exchange
reversible: true
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110060#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110060#

metaR ARAB Lt
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
product: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
name: L-arabinoase extracellular transport
type: Reaction

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_8fd0f294_4fcb_4c00_9345_af009ed9f497
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:953
is: Q86VV3
name: ENTPD1
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_97a23546_4a6d_40ab_8438_31b72f7b28cf
boundary condition: true
is encoded by: hsa:8818
initial amount: NaN
constant: false
is: O94777
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: DPM2

http://identifiers.org/biomodels.db/MODEL1310110060#_38e25767_be48_4ad0_b3bc_1ee7dea4ff32
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q96CD2
constant: false
type: Species
is encoded by: hsa:60490
name: PPCDC
initial concentration: NaN

metaM dtdp n
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
boundary condition: false
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial amount: NaN
is: HMDB01274
is: SBO:0000247
is: CHEBI:58369

metaM ksi deg12 l
boundary condition: false
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
type: Species
name: keratan sulfate I, degradation product 12
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_475f0838_30e6_42c4_ba1e_717ef00772a4
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:7296
name: TXNRD1
is: SBO:0000252
initial concentration: NaN

metaM L2aadp m
is: CHEBI:58672
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
type: Species
is: SBO:0000247
name: L-2-aminoadipate(1-)
is: HMDB00510
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_6b51c73f_5754_4c68_a9b9_02440f818405
boundary condition: true
is encoded by: hsa:6548
has only substance units: false
name: SLC9A1
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: P19634

metaR FERO
name: ferroxidase
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000134
reversible: false
is: SBO:0000176
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR r0129
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110060#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40

http://identifiers.org/biomodels.db/MODEL1310110060#_b4a5935e_b1de_45bc_9ecb_d77f041634af
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: GGT7
is encoded by: hsa:2686
type: Species
has only substance units: false
is: A0PJJ9

http://identifiers.org/biomodels.db/MODEL1310110060#_f95f7261_0457_435c_b0ab_bb74c3af22d9
initial concentration: NaN
name: EHHADH
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: Q9NY65
initial amount: NaN
is encoded by: hsa:1962
constant: false

metaR SPHS1Ptr
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
name: sphingosine-1-phosphate transport
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_261a1640_558f_40b6_8e53_1b926804e9ad
is: P36969
constant: false
is encoded by: hsa:2879
type: Species
boundary condition: true
name: GPX4
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_8f138541_b5eb_4342_b6e0_9af5946ee1cd
constant: false
is encoded by: hsa:144195
type: Species
has only substance units: false
is: Q8TDB8
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC2A14
is: SBO:0000252

metaR G14T2g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
kinetic law: MODEL1310110060#

metaM chsterol e
initial amount: NaN
has only substance units: false
name: cholesterol
is: HMDB00067
initial concentration: 1.0
type: Species
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
constant: false
is: SBO:0000247

metaR N3Tg
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
fast: false
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110060#
reversible: false
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.122

metaM crm hs r
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:52639
type: Species
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
has only substance units: false
name: N-acylsphingosine

metaM lnlnca l
initial amount: NaN
initial concentration: 1.0
name: alpha-linolenate
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01388
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_73e0af33_ea24_44ad_89a2_fb5eb706ab0a
type: Species
is encoded by: hsa:4830
constant: false
name: NME1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_f77683d3_ff7a_4493_b110_93a266294103
name: _T83654_1_e
constant: false
initial concentration: NaN
is encoded by: hsa:T83654
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaR RE3241R
reversible: false
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
kinetic law: MODEL1310110060#
type: Reaction
fast: false
name: RE3241
modifier: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_ad3de3f3_3eda_4c87_b230_2ba8be9cbc93
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q969I6
is encoded by: hsa:55089
constant: false
initial amount: NaN
name: SLC38A4
type: Species
initial concentration: NaN

metaR r0688
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
fast: false
is: SBO:0000176
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction

metaM tsul m
initial amount: NaN
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247
is: HMDB00257
is: CHEBI:16094
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_66280165_25c1_437f_b0d6_c3cb99d947a7
has only substance units: false
type: Species
is encoded by: hsa:AU149534
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: _AU149534_1_m
initial concentration: NaN

metaR G6Pter
reactant: MODEL1310110060#
type: Reaction
reversible: true
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
is described by: ECO:0000269
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false

metaR CO2tm
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
name: CO2 transport (diffusion), mitochondrial
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_b21124fa_1fdc_42b3_9f79_7b617b919a87
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: O95263
name: PDE8B
type: Species
is encoded by: hsa:8622

http://identifiers.org/biomodels.db/MODEL1310110060#_2e78bf3a_37a1_459d_8f05_811f276d1e0e
is encoded by: hsa:248
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: ALPI
is: P09923
initial amount: NaN
initial concentration: NaN

metaR HOXG
is: SBO:0000176
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
reversible: false
type: Reaction
fast: false
name: Heme oxygenase 1
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.14.99.3
is described by: ECO:0000134
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#

metaR r0715
type: Reaction
product: MODEL1310110060#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.5
reversible: false
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaM dolmanp U r
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:15809
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human uterine homolog
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species

metaR r2030
product: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110060#
type: Reaction
reversible: false
kinetic law: MODEL1310110060#

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_afa3045f_3ab8_4259_9a69_1ffb7fdd4e4e
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC5A3
type: Species
is encoded by: hsa:6526
constant: false
boundary condition: true
is: P53794

metaR NDP7er
product: MODEL1310110060#
reversible: false
kinetic law: MODEL1310110060#
type: Reaction
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum

metaM ksii core4 pre2 g
is: C00130
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: keratan sulfate II boisynthesis, precursor 2
is: HMDB00175
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110060#_c082abd6_0206_4f1f_a3d1_0e318f5d93f1
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: GMPR2
is encoded by: hsa:51292
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM pmtcoa m
is: CHEBI:57379
has only substance units: false
constant: false
is: C00154
is: HMDB01338
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_2ca2bfa0_44e4_4b7b_9037_64e5920206ba
is: B3KXN9
initial concentration: NaN
name: ADO
constant: false
boundary condition: true
is encoded by: hsa:84890
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM h r
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: C00080
is: http://identifiers.org/pubchem.compound/3380
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110060#_23c4e327_ad51_4eff_8969_7741b9b29399
is encoded by: hsa:5140
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q13370
name: PDE3B
type: Species
constant: false

metaM thf m
is: SBO:0000247
is: C00101
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0
is: HMDB01846
has only substance units: false
initial amount: NaN
type: Species
name: 5,6,7,8-Tetrahydrofolate
boundary condition: false
is: CHEBI:57453

metaM ksi deg40 l
is: HMDB00143
has only substance units: false
name: keratan sulfate I, degradation product 40
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C40H68N2O31 CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_1ceb04f6_dc3b_4171_87b0_897f84159b2d
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4645
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q9H6Y6
initial amount: NaN
name: MYO5B

metaR GLCNACPT U
fast: false
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.8.15
reversible: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
type: Reaction

metaR r0714
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110060#
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#

metaM din e
type: Species
is: SBO:0000247
is: HMDB00071
is: CHEBI:28997
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C05512
initial amount: NaN
constant: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
name: Deoxyinosine

http://identifiers.org/biomodels.db/MODEL1310110060#_555faf59_ff6b_41ef_9ccd_dfca8f3cc2ac
name: SULT1A1
boundary condition: true
is encoded by: hsa:6817
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaM lnlnca e
name: alpha-linolenate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:32387
type: Species
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388
constant: false

metaM ksi pre6 g
notes: FORMULA: C107H174N7O80SX CHARGE: -2
name: keratan sulfate I biosynthesis, precursor 6
type: Species
is: CHEBI:58053
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
has only substance units: false
is: C00130

metaR RE2626M
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction
reversible: true
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
fast: false
is: SBO:0000176
name: RE2626
product: MODEL1310110060#

metaM focytC m
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: Ferrocytochrome C
is: CHEBI:16928
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
boundary condition: false
initial concentration: 1.0

metaM zymst r
is: SBO:0000247
name: zymosterol
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
initial concentration: 1.0
boundary condition: false
is: CHEBI:18252
is: HMDB06271
type: Species
has only substance units: false
constant: false

metaR r0791
fast: false
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_da5cb312_1bbf_4736_b3c1_5c030eb0ad70
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: PDE4C
constant: false
is encoded by: hsa:5143
has only substance units: false
is: Q7KYS4
type: Species
is: SBO:0000252

metaM malcoa c
constant: false
is: CHEBI:57384
has only substance units: false
type: Species
name: Malonyl-CoA
is: HMDB01175
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00083
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_fee6c638_c985_4e97_b0af_b51c5ec41a04
is: P30520
constant: false
type: Species
is encoded by: hsa:159
name: ADSS
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR S23Tg
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110060#
modifier: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
type: Reaction
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_fd681cae_95ee_4a52_99a5_a8048649875b
initial amount: NaN
name: HEPH
is encoded by: hsa:9843
constant: false
boundary condition: true
is: SBO:0000252
is: E9PHN8
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_43564d9a_64c9_45f1_9142_0cf0e816a9f8
name: ENTPD8
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q5MY95
has only substance units: false
is encoded by: hsa:377841

http://identifiers.org/biomodels.db/MODEL1310110060#_62362869_887c_4ebe_aeaa_f264e83c3bce
name: _AI971036_1_x
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI971036
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_aabe1021_9a35_4f7e_95ca_0df4bb44633b
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: P49902
type: Species
is: SBO:0000252
is encoded by: hsa:22978
name: NT5C2
boundary condition: true

metaR KCCt
modifier: MODEL1310110060#
name: K+-Cl- cotransport
is: SBO:0000185
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
reactant: MODEL1310110060#

metaR IDOAASE3ly
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.76
name: alpha-L-iduronidase, lysosomal
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176

metaM 2mop c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01172
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: CHEBI:57700
constant: false
has only substance units: false
type: Species

metaR CSNAT2x
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.137
is described by: ECO:0000269
modifier: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR VALTAm
is described by: ECO:0000269
reversible: true
name: valine transaminase, mitochondiral
reactant: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is: SBO:0000176
product: MODEL1310110060#

metaR PPItm
type: Reaction
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
kinetic law: MODEL1310110060#
name: diphopshate transporter, mitochondrial
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
fast: false

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM ksii core2 l
type: Species
is: HMDB01014
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:57255
is: SBO:0000247
name: keratan sulfate II (core 2-linked)
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_12418914_5a5e_47da_a9ef_7f9db8151599
has only substance units: false
name: ALG3
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:10195
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_83136c9a_4118_44de_b656_b8c45b23c426
initial amount: NaN
name: SI
is: P14410
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:6476
constant: false
has only substance units: false

metaM btcoa m
is: CHEBI:57371
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: Butanoyl-CoA
is: C00136
is: HMDB01088

metaR NDP7g
modifier: MODEL1310110060#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reversible: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR GUAt
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
product: MODEL1310110060#
is: SBO:0000185
modifier: MODEL1310110060#
name: Guanine transport
reversible: true
reactant: MODEL1310110060#
is described by: ECO:0000269
type: Reaction

metaM ksi pre2 g
is: C00130
initial amount: NaN
boundary condition: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
constant: false
is: SBO:0000247
type: Species
is: HMDB00175
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 2

metaR RE0691C
kinetic law: MODEL1310110060#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: RE0691
product: MODEL1310110060#

metaM amet c
initial amount: NaN
is: C00019
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
is: SBO:0000247
has only substance units: false
name: S-Adenosyl-L-methionine
constant: false
type: Species
initial concentration: 1.0
is: HMDB01185

http://identifiers.org/biomodels.db/MODEL1310110060#_217a7abb_9fea_41b4_ac0c_13f0125099af
is encoded by: hsa:171425
is: SBO:0000252
constant: false
name: CLYBL
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false

metaR GluForTx
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
reversible: false
is described by: ECO:0000269
fast: false
name: Glutamate formimidoyltransferase
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.1.2.5

metaR HMGCOARc
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000134
type: Reaction
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
kinetic law: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: false

metaR RE2069C
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
name: RE2069
reversible: true
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#

metaM thymd e
has only substance units: false
initial concentration: 1.0
name: Thymidine
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: C00214
constant: false
is: HMDB00273
is: CHEBI:17748

metaR PAIL HStn
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
name: phosphatidylinositol nuclear transport (diffusion)
product: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true

metaM cit c
is: SBO:0000247
is: HMDB00094
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
initial amount: NaN
boundary condition: false
type: Species
is: C00158
constant: false
initial concentration: 1.0
has only substance units: false
name: Citrate

metaM 4abut e
is: SBO:0000247
is: CHEBI:3628
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: 4-Aminobutanoate
has only substance units: false
initial concentration: 1.0
is: HMDB00112

metaR r2031
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110060#

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM din c
type: Species
is: HMDB00071
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28997
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: C05512
name: Deoxyinosine
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_5d761b03_1d4c_4cbe_8202_f0082ddddc1e
initial amount: NaN
is: Q53H96
constant: false
is encoded by: hsa:65263
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PYCRL
initial concentration: NaN

metaR NACHEX24ly
kinetic law: MODEL1310110060#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
modifier: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000176
product: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110060#_f363abca_f7d4_40e7_9ff4_6ebcb34a5519
is encoded by: hsa:63917
is: B3KWF4
has only substance units: false
boundary condition: true
name: GALNT11
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaM pheme m
boundary condition: false
is: HMDB03178
initial concentration: 1.0
is: SBO:0000247
is: C00032
initial amount: NaN
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: CHEBI:17627
type: Species
constant: false
name: Protoheme

http://identifiers.org/biomodels.db/MODEL1310110060#_29c95a21_1c16_40b6_b208_958fccc0e283
is: SBO:0000252
is: P22413
type: Species
has only substance units: false
name: ENPP1
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5167

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR G14T13g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110060#

metaR PSFLIPm
name: phosphatidylserine flippase
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.6.3.1
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
reversible: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185

metaM HC01672 c
constant: false
is: CHEBI:37666
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Acetyl adenylate

http://identifiers.org/biomodels.db/MODEL1310110060#_63b8c73e_c242_4d8d_9424_5e88f102cee2
constant: false
initial concentration: NaN
is encoded by: hsa:412
has only substance units: false
type: Species
boundary condition: true
name: STS
is: P08842
initial amount: NaN
is: SBO:0000252

metaR CYSt4
fast: false
name: L-cysteine reversible transport via sodium symport
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is: SBO:0000185
reversible: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
is described by: ECO:0000304
reactant: MODEL1310110060#

metaR DURIt
kinetic law: MODEL1310110060#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
name: deoxyuridine transport via diffusion
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
reactant: MODEL1310110060#

metaM strdnccoa m
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
name: stearidonyl coenzyme A
initial amount: NaN
is: HMDB06519
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205473
is: C16163
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_e0314251_0410_4319_aac5_1aebfc536b35
boundary condition: true
name: ND1
type: Species
constant: false
has only substance units: false
is: Q85KV6
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4535
is: SBO:0000252

metaM hs deg2 l
constant: false
initial concentration: 1.0
is: CHEBI:17180
name: heparan sulfate, degradation product 2
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
is: HMDB01352

metaR KSII CORE4t
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false
type: Reaction
kinetic law: MODEL1310110060#
name: keratan sulfate II (core4) transport, golgi to extracellular

metaR r1652
modifier: MODEL1310110060#
fast: false
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR O2tp
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: O2 transport, peroxisomal
product: MODEL1310110060#
reactant: MODEL1310110060#

metaR r1588
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction

metaR OBDHc
is: SBO:0000176
kinetic law: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
name: 2-Oxobutanoate dehydrogenase, cytosolic
fast: false
type: Reaction

metaR AKR1C42
type: Reaction
fast: false
modifier: MODEL1310110060#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
kinetic law: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_b188999b_ca24_4caa_a257_28200f5272f6
constant: false
has only substance units: false
is: SBO:0000252
is: P60891
is encoded by: hsa:5631
initial amount: NaN
name: PRPS1
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_892c0096_7dac_4e9c_9306_6b6e888c720b
is encoded by: hsa:55350
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: VNN3
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_eaa8d3ec_9c25_4aea_a773_3d29dafedb1c
has only substance units: false
boundary condition: true
is encoded by: hsa:4967
name: OGDH
initial amount: NaN
is: B4E3E9
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r1589
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_7c413495_a581_4048_96e0_ab5f5a28de86
name: IMPDH2
has only substance units: false
is: SBO:0000252
type: Species
is: P12268
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3615
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_e82a66cb_2fc7_47fe_b5d8_cdd3f366e73a
is encoded by: hsa:11112
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: P31937
initial concentration: NaN
is: SBO:0000252
name: HIBADH

http://identifiers.org/biomodels.db/MODEL1310110060#_b303bebe_550b_43e6_bdc9_2c119ebbfbc8
name: HK3
is encoded by: hsa:3101
initial amount: NaN
constant: false
type: Species
is: P52790
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR DOLPH Uer
product: MODEL1310110060#
fast: false
name: Dolichol-phosphate phosphohydrolase, human (uterus)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#

metaR AG13T5g
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_b823bcf9_0645_41d2_bf06_aca39c52102e
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI769281
boundary condition: true
is: SBO:0000252
name: _AI769281_1_e
initial amount: NaN
type: Species

metaR r1651
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
modifier: MODEL1310110060#
fast: false

metaM 13dpg c
constant: false
is: CHEBI:57604
boundary condition: false
is: http://identifiers.org/pubchem.compound/3535
is: HMDB01270
is: C00236
is: SBO:0000247
initial amount: NaN
name: 3-Phospho-D-glyceroyl phosphate
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
initial concentration: 1.0
type: Species
has only substance units: false

metaR r0308
reactant: MODEL1310110060#
reversible: false
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000000
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
is: SBO:0000176
fast: false

metaR r2514
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
reversible: true
type: Reaction

metaR GLCAASE8ly
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110060#
is: SBO:0000176
name: beta-glucuronidase, lysosomal
product: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110060#
reversible: false

metaR S6TASE2ly
is described by: ECO:0000000
product: MODEL1310110060#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110060#
reversible: true
type: Reaction
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is: SBO:0000176
kinetic law: MODEL1310110060#

metaM CE0785 m
is: CHEBI:57795
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
name: cis,cis-myristo-5,8-dienoyl-CoA
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
has only substance units: false

metaR 5AOPtm
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
fast: false
reversible: true
is: SBO:0000185
name: 5-Aminolevulinate mitochondrial transport

http://identifiers.org/biomodels.db/MODEL1310110060#_3582d2ce_9617_4de1_9eaa_a3932a929781
boundary condition: true
initial concentration: NaN
constant: false
is: O95139
type: Species
name: NDUFB6
initial amount: NaN
is encoded by: hsa:4712
has only substance units: false
is: SBO:0000252

metaM retinol c
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
name: retinol
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:50211
is: HMDB00305
initial amount: NaN

metaR ALCD21 L
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
fast: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: false
name: alcohol dehydrogenase (L-1,2-propanediol)
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.99.24
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_be56b613_f661_4585_97ab_6dc6ed16b602
is: SBO:0000252
constant: false
boundary condition: true
name: _AI924226_1_m
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI924226
initial concentration: NaN

metaM ksi deg6 l
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
has only substance units: false
name: keratan sulfate I, degradation product 6
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_cb14fc69_2b4d_4dad_af4e_70be524e0922
boundary condition: true
is: P33908
name: MAN1A1
is: SBO:0000252
is encoded by: hsa:4121
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_aecc0fa4_bf98_4104_a528_3dbe4f390399
initial concentration: NaN
is encoded by: hsa:AI345944
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: _AI345944_1_m

http://identifiers.org/biomodels.db/MODEL1310110060#_0fe3b45b_6877_4f3e_ad5e_654aefcab24f
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: NDUFB2
boundary condition: true
initial amount: NaN
is encoded by: hsa:4708
is: H7C5B8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_85b2669b_3b6b_4d95_8389_ac079f6a9ba7
is: SBO:0000252
is encoded by: hsa:T83654
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _T83654_1_m
has only substance units: false

metaR RDH3a
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
fast: false
modifier: MODEL1310110060#
product: MODEL1310110060#
name: retinol dehydrogenase (11-cis,NADPH)
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reactant: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.300
kinetic law: MODEL1310110060#
reversible: true

metaR PRO1x
reversible: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
type: Reaction
name: L-ProlineNAD+ 5-oxidoreductase
fast: false
is version of: http://identifiers.org/ec-code/1.5.99.8
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110060#_14bbd378_5746_4856_84cb_ffc1bc1e8569
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: P18545
is encoded by: hsa:5148
name: PDE6G
has only substance units: false
constant: false

metaR r0730
is described by: ECO:0000000
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reversible: false
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR r1586
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_4e9bc12c_c4e0_486e_aaff_ab74f81e2c7a
has only substance units: false
constant: false
initial concentration: NaN
name: DDC
type: Species
boundary condition: true
is encoded by: hsa:1644
is: SBO:0000252
initial amount: NaN
is: Q53Y41

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR r1654
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110060#
fast: false
is: SBO:0000185
reactant: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE3568C
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
name: RE3568
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_5096583c_f940_4143_9bb2_25610dc3525d
type: Species
constant: false
is encoded by: hsa:5634
is: P11908
has only substance units: false
name: PRPS2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR DCTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110060#
name: dCTP diffusion in nucleus

metaM HC10852 r
is: SBO:0000247
is: CHEBI:61540
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
has only substance units: false
boundary condition: false
name: palmitoleyl-CoA(4-)
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_d36b3c7c_9d7b_42dc_8b02_05a10d50f86d
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR r0509
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000176
type: Reaction
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
product: MODEL1310110060#

metaR RE1516M
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110060#
is: SBO:0000176
name: RE1516
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_5cc0707a_02b2_491e_9d45_d9b5343e3d15
name: ACSL3
type: Species
is: B3KMA6
has only substance units: false
boundary condition: true
is encoded by: hsa:2181
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_1f3cd09a_ad6c_421b_beb6_a41a1ebc8dcd
constant: false
is: D3DNH0
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:2992
is: SBO:0000252
name: GYG1

metaR S6TASE12ly
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_bf630833_de4d_4da6_8ed3_d923f8257cb5
constant: false
is encoded by: hsa:1607
boundary condition: true
name: DGKB
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaR r2516
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
reactant: MODEL1310110060#
type: Reaction
reversible: true

metaR r1587
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
is: SBO:0000185

metaM ksii core2 pre4 g
is: C00130
is: CHEBI:58053
constant: false
notes: FORMULA: C53H86N4O38X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 4
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00175

metaR r0731
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000000
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110060#
reversible: false
fast: false
type: Reaction
product: MODEL1310110060#

metaR DOLPGT2 Uer
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
fast: false
modifier: MODEL1310110060#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.265
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_2e72afc1_f4e1_453a_8ac2_4315b5796b06
name: PYCR2
type: Species
initial amount: NaN
is: Q96C36
constant: false
has only substance units: false
is encoded by: hsa:29920
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR 1PPDCRp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaR r1653
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110060#
fast: false
product: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_91b7de88_c1ec_4a35_bd34_724b5dc97b8d
has only substance units: false
name: HK1
type: Species
boundary condition: true
initial amount: NaN
is: B3KXY9
constant: false
is encoded by: hsa:3098
initial concentration: NaN
is: SBO:0000252

metaM retinol e
is: CHEBI:50211
boundary condition: false
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial concentration: 1.0
type: Species
name: retinol
is: HMDB00305
is: SBO:0000247
initial amount: NaN
constant: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_33b05407_c156_4262_bec9_74871ce9720e
constant: false
initial concentration: NaN
is: F5GWS5
boundary condition: true
is encoded by: hsa:55811
is: SBO:0000252
has only substance units: false
name: ADCY10
initial amount: NaN
type: Species

metaR r0502
is: SBO:0000176
modifier: MODEL1310110060#
product: MODEL1310110060#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#

metaR RTOTALt
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
reversible: true
product: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: RTOTAL transport
reactant: MODEL1310110060#

metaR r2519
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
name: Utilized transport
kinetic law: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction

metaM 4mlacac c
constant: false
is: CHEBI:17105
initial amount: NaN
name: 4-maleylacetoacetate
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
initial concentration: 1.0
is: HMDB02052
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_86b375c8_4fb3_40a3_9406_c00ca641f64a
initial amount: NaN
is encoded by: hsa:7166
is: SBO:0000252
constant: false
initial concentration: NaN
name: TPH1
is: P17752
has only substance units: false
type: Species
boundary condition: true

metaM 7dhf e
initial concentration: 1.0
constant: false
name: heptaglutamyl folate (DHF)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
boundary condition: false
type: Species
is: HMDB06559
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_d0a18d9a_3669_4a98_88c0_e00fea269d35
initial concentration: NaN
has only substance units: false
constant: false
is: Q16739
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: UGCG
is encoded by: hsa:7357

metaM pail345p hs c
is: CHEBI:57836
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial concentration: 1.0
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
has only substance units: false
constant: false

MODEL1310110060
reaction: metaR EX CE5786 LPAREN e RPAREN
reaction: metaR DIDPtn
species: metaM nadp r
species: metaM adn e
species: metaM dpcoa c
species: metaM ksi pre17 g
species: metaM CE0849 m
reaction: metaR r1596
species: metaM dadp m
species: metaM nac c
reaction: metaR r2403
reaction: metaR RE1342C
reaction: metaR EX g1p LPAREN e RPAREN
species: metaM atp m
reaction: metaR P450SCC1m
reaction: metaR CGLYt3 2
reaction: metaR RAI1
reaction: metaR r0210
reaction: metaR AICARte
reaction: metaR r1603
reaction: metaR GGH 7DHFe
reaction: metaR CYTK12
species: metaM mthgxl c
reaction: metaR UMPK7
reaction: metaR r2358
species: metaM HC00361 c
species: metaM HC02204 e
reaction: metaR EX rib D LPAREN e RPAREN
reaction: metaR PETOHMm hs
reaction: metaR FAOXC1811603m
reaction: metaR CLOHtex2
reaction: metaR INSTt2r
reaction: metaR S6TASE25ly
species: metaM f1a l
reaction: metaR DURAD
species: metaM crn r
reaction: metaR AG13T17g
species: metaM amet m
reaction: metaR SPHK21c
reaction: metaR ACCOAC
reaction: metaR NDPK4n
reaction: metaR PHEMEtm
species: metaM coa c
reaction: metaR r0413
reaction: metaR HEX7
reaction: metaR ADK3m
reaction: metaR r2090
species: metaM 1pyr5c m
reaction: metaR UGLT
species: metaM CE2432 m
species: metaM CE5160 r
species: metaM acald m
species: metaM meoh l
reaction: metaR SCP22x
reaction: metaR r0173
reaction: metaR 4MOPt2im
species: metaM glc D c
reaction: metaR r0668
reaction: metaR EX ksi LPAREN e RPAREN
reaction: metaR PROSTGE2t2
reaction: metaR PUNP4
reaction: metaR r0885
species: metaM crm hs c
reaction: metaR TDCHOLAte
species: metaM ksi pre10 g
reaction: metaR GGT6
species: metaM pi e
reaction: metaR MTHFDm
reaction: metaR MECOALm
reaction: metaR r2364
reaction: metaR EX co LPAREN e RPAREN
reaction: metaR ETOHt
reaction: metaR GLCNACASE4ly
species: metaM didp c
reaction: metaR CYTK4n
reaction: metaR r2111
species: metaM hdcea e
reaction: metaR HCO3 CLt
species: metaM nadph m
species: metaM ksi pre29 g

metaM mescoa m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: SBO:0000247
type: Species
is: C06028
name: Mesaconyl-CoA
initial amount: NaN
is: CHEBI:27969
has only substance units: false
constant: false

metaM dudp c
constant: false
is: CHEBI:60471
is: C01346
is: SBO:0000247
type: Species
boundary condition: false
name: dUDP
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_4e29edf9_085a_4bb0_aa42_3ac6b7feda42
constant: false
is encoded by: hsa:6487
is: Q5T4Y1
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ST3GAL3

metaM crn e
constant: false
initial concentration: 1.0
is: C00318
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16347
name: L-Carnitine

http://identifiers.org/biomodels.db/MODEL1310110060#_e32f9022_042b_4bc1_8f03_7b45951ad1c7
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:5373
constant: false
is: O15305
name: PMM2
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR O2tm
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
fast: false
reversible: true
name: O2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is: SBO:0000185

metaR ACNAM9PL
product: MODEL1310110060#
type: Reaction
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.5.1.56
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110060#
reversible: false

metaR r1378
kinetic law: MODEL1310110060#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reversible: true
reactant: MODEL1310110060#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
product: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_f9be7f26_b715_4ffd_995f_64713188ab25
boundary condition: true
constant: false
name: SULT1A1
is encoded by: hsa:6817
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P50225

metaM bglc e
name: beta-glucans
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00672
notes: FORMULA: C1200000H2200000O1100000 CHARGE: 0
has only substance units: false
constant: false
boundary condition: false
is: C08260

metaM dtdp c
constant: false
type: Species
is: HMDB01274
name: dTDP
is: SBO:0000247
boundary condition: false
is: C00363
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
is: CHEBI:58369
has only substance units: false

metaM anth e
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: HMDB01123
has only substance units: false
is: CHEBI:16567
name: anthranilate

metaM for e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: formate
is: CHEBI:15740
constant: false
type: Species
has only substance units: false
is: HMDB00142
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM ahcys m
type: Species
initial amount: NaN
is: HMDB00939
is: SBO:0000247
constant: false
has only substance units: false
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
is: CHEBI:16680
boundary condition: false
is: C00021
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

metaM cys L e
initial amount: NaN
boundary condition: false
is: CHEBI:17561
name: L-cysteine
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
has only substance units: false
is: HMDB00574
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a39fc149_fe7a_43f1_8ffa_a669256a159b
has only substance units: false
is encoded by: hsa:762
constant: false
is: Q6FHI7
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: CA4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_b8b9c212_aa87_4cc4_92ab_f4375409787e
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is: Q548A7
name: SLC26A6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:65010

http://identifiers.org/biomodels.db/MODEL1310110060#_b55b757c_b733_4fb6_b7f2_f06dee81a91c
is: P11310
is encoded by: hsa:34
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: ACADM
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_0f5ed468_a793_4bb8_8ae6_115cdf601ba7
name: GPX6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:257202
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: P59796

metaR r0504
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: true
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is: SBO:0000176
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2

metaR r1650
modifier: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110060#

metaR r1377
reversible: true
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_dcbf33b4_c359_4fd3_a9c0_0810912ba8e6
name: CPT1B
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q92523
constant: false
is encoded by: hsa:1375
type: Species
initial amount: NaN

metaR O2tn
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: O2 nuclear transport
is described by: ECO:0000000
product: MODEL1310110060#
reversible: true

metaR MANtly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
is: SBO:0000185
name: mannose efflux from lysosome
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000

metaR CYOOm3
name: cytochrome c oxidase, mitochondrial Complex IV
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.9.3.1
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
product: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
is described by: ECO:0000134
modifier: MODEL1310110060#
is: SBO:0000185
type: Reaction
fast: false

metaR INSTt4
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
modifier: MODEL1310110060#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110060#
name: inositol transport via sodium symport
product: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_307a24f4_a1f2_47eb_9cef_da1746dfad07
is encoded by: hsa:27068
initial amount: NaN
name: PPA2
is: SBO:0000252
initial concentration: NaN
constant: false
is: F8WDN9
boundary condition: true
has only substance units: false
type: Species

metaR DSAT
type: Reaction
fast: false
product: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
name: dihydrosphingosine N-acyltransferase
kinetic law: MODEL1310110060#

metaM hdd2coa m
is: SBO:0000247
name: trans-Hexadec-2-enoyl-CoA
is: CHEBI:61526
has only substance units: false
is: HMDB03945
initial amount: NaN
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
boundary condition: false
is: C05272
initial concentration: 1.0

metaM CE5117 m
is: CHEBI:12947
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
constant: false
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM CE5120 m
is: CHEBI:12947
has only substance units: false
boundary condition: false
name: trans-2-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_3c58f4dc_80e4_47ab_a7b6_264f2c97a141
name: CYP8B1
initial concentration: NaN
constant: false
is encoded by: hsa:1582
boundary condition: true
is: SBO:0000252
is: Q9UNU6
type: Species
initial amount: NaN
has only substance units: false

metaR S6T16g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is: SBO:0000176
reactant: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM mmcoa S m
constant: false
is: HMDB02310
has only substance units: false
is: SBO:0000247
name: (S)-methylmalonyl-CoA(5-)
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
is: CHEBI:57327
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR PPAm
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
name: inorganic diphosphatase
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110060#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f4edd58e_d636_4990_8d97_3d6cc2d5f97d
constant: false
has only substance units: false
is: B3KQ63
is: SBO:0000252
name: HPD
initial amount: NaN
boundary condition: true
is encoded by: hsa:3242
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_a991795f_98aa_4f6e_8d77_f585e20b3d48
is encoded by: hsa:27124
boundary condition: true
initial concentration: NaN
name: INPP5J
has only substance units: false
is: Q15735
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaM crn c
is: SBO:0000247
boundary condition: false
is: HMDB00062
constant: false
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
is: C00318
has only substance units: false
is: CHEBI:16347
initial amount: NaN
type: Species

metaR S6T5g
kinetic law: MODEL1310110060#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110060#
fast: false
reversible: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110060#
is: SBO:0000176

metaM xol7aone r
boundary condition: false
is: HMDB01993
constant: false
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:17899
type: Species
name: 7alpha-hydroxycholest-4-en-3-one

http://identifiers.org/biomodels.db/MODEL1310110060#_c413937c_a623_4d2e_827d_9dd9159129ba
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC26A6
has only substance units: false
is encoded by: hsa:65010
is: Q9Y3Y1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_b862976f_4ab7_4910_b406_474c30f402eb
initial amount: NaN
is: P33897
name: ABCD1
has only substance units: false
is encoded by: hsa:215
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaM ump r
type: Species
name: UMP
is: CHEBI:57865
is: HMDB00288
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_62848450_800f_44fd_8bcd_b4a9255a2dab
name: PDE6H
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q13956
is encoded by: hsa:5149

metaM CE5101 m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
is: CHEBI:57795
constant: false
boundary condition: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_fd5aa718_b8f9_438d_8525_629cd3d1419c
is encoded by: hsa:11238
type: Species
is: SBO:0000252
is: Q9Y2D0
initial amount: NaN
boundary condition: true
constant: false
name: CA5B
has only substance units: false
initial concentration: NaN

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_f5e3c821_3c88_4fc6_9af7_fbf65f05b164
is: P51570
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2584
type: Species
constant: false
boundary condition: true
name: GALK1
has only substance units: false
initial amount: NaN

metaM dtdp e
boundary condition: false
is: HMDB01274
constant: false
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_d8ce7fb3_a539_45fa_b1a0_2aa7bef368d5
has only substance units: false
is: SBO:0000252
type: Species
is: Q13011
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: ECH1
is encoded by: hsa:1891

metaM cys L c
is: HMDB00574
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: L-cysteine
initial concentration: 1.0
is: CHEBI:17561
constant: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
boundary condition: false

metaM anth c
is: HMDB01123
initial concentration: 1.0
is: CHEBI:16567
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial amount: NaN
constant: false
boundary condition: false
name: anthranilate
is: SBO:0000247
has only substance units: false
type: Species

metaM uacgam g
has only substance units: false
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
is: CHEBI:57705

metaR IDOAASE1ly
name: alpha-L-iduronidase, lysosomal
kinetic law: MODEL1310110060#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110060#
reversible: false
product: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reactant: MODEL1310110060#

metaM hdd2coa x
type: Species
constant: false
is: CHEBI:61526
initial amount: NaN
name: (E)-hexadec-2-enoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
is: HMDB03945
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272

metaM asn L e
name: L-asparagine
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
boundary condition: false
is: CHEBI:17196
has only substance units: false

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR GMPtg
is described by: ECO:0000269
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000185
name: GMP transport (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
fast: false
reversible: true
reactant: MODEL1310110060#
product: MODEL1310110060#

metaR PRDXl
is described by: ECO:0000000
name: Peroxidase (multiple substrates)
fast: false
type: Reaction
product: MODEL1310110060#
reversible: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (4353.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10777476,PMID:14972011 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.11.2.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_7acd65ab_a90e_4c86_bcf2_3219dd57ac2b
is: Q9UN76
has only substance units: false
name: SLC6A14
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:11254

http://identifiers.org/biomodels.db/MODEL1310110060#_5032eed3_fe98_496a_88dd_5534648a73cf
type: Species
has only substance units: false
initial amount: NaN
name: PDE9A
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:5152

metaR r1435
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Transport reaction
product: MODEL1310110060#

metaR HSPGtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: heparan sulfate transport, extracellular to lysosome
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
fast: false
reversible: false

metaM dgchol x
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
boundary condition: false
is: HMDB00637
type: Species
is: CHEBI:36252
initial concentration: 1.0
name: glycochenodeoxycholate
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_9275597a_0a37_48d5_8f59_c3b4f195b88d
is encoded by: hsa:4200
type: Species
has only substance units: false
is: P23368
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ME2
initial amount: NaN

metaR CRNt
product: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: L-carnitine reversible transport
fast: false
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_f1800d5d_3d64_43e2_91a5_499fa483d957
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2592
initial concentration: NaN
initial amount: NaN
name: GALT
type: Species
has only substance units: false
is: B4E097

metaM gdpfuc g
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
name: GDP-L-fucose(2-)
is: HMDB01095
is: CHEBI:57984
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

http://identifiers.org/biomodels.db/MODEL1310110060#_ad59b3ef_2775_4dc8_9dac_e3f0812a5f8f
initial amount: NaN
boundary condition: true
constant: false
name: ACAT2
initial concentration: NaN
type: Species
is encoded by: hsa:39
has only substance units: false
is: SBO:0000252
is: Q9BWD1

http://identifiers.org/biomodels.db/MODEL1310110060#_24f0e434_88f7_407a_adc2_1acfc7913a6f
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI620219
has only substance units: false
type: Species
constant: false
name: _AI620219_1_c
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_d04f1e7a_9687_4de7_bf56_a0c9e0d8268a
initial amount: NaN
initial concentration: NaN
name: ENPP3
has only substance units: false
is: Q308M7
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:5169
constant: false

metaM dudp n
is: SBO:0000247
name: dUDP(3-)
is: HMDB01000
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:60471
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false

metaR GGH 10FTHF5GLUe
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
is: SBO:0000176
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular

http://identifiers.org/biomodels.db/MODEL1310110060#_6c1ea3d9_1804_4b1d_990a_cd1648a861ca
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:217
name: ALDH2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P05091
constant: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_fb8da8ac_c910_4b2f_bef7_f62a745a99c2
initial amount: NaN
is: D3DX95
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1103
constant: false
name: CHAT
is: SBO:0000252

metaR r1659
modifier: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#

metaR ABTD
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
reactant: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
name: L-arabinitol 4-dehydrogenase
fast: false
type: Reaction
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000176

metaR NACHEX22ly
is: SBO:0000176
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_fed463ae_d7bb_43ec_9239_a1d082f4d49f
name: ST6GAL1
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P15907
is encoded by: hsa:6480
initial concentration: NaN
has only substance units: false
type: Species

metaR CLOHtex2
reversible: false
is described by: ECO:0000304
reactant: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
name: chloride transport via hydroxide countertransport (2:1)
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction

metaR BHBtm
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
fast: false
product: MODEL1310110060#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport

http://identifiers.org/biomodels.db/MODEL1310110060#_d5aadf13_7b74_42c7_a49e_11e2846f61c1
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFA7
is encoded by: hsa:4701
has only substance units: false
is: Q6FG42
initial amount: NaN
boundary condition: true
constant: false

metaM bildglcur e
is: HMDB03325
is: CHEBI:58471
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: bis(beta-glucosyluronate)bilirubin

metaM asn L c
initial concentration: 1.0
is: CHEBI:17196
type: Species
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: L-asparagine
is: HMDB00168

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR RE3627M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3627
modifier: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
type: Reaction

metaR CHOLtu
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is described by: ECO:0000269
name: Choline uniport
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_f189f0d0_1deb_4ef1_91c2_cfd0aa8596d2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5330
is: Q59F77
has only substance units: false
name: PLCB2
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaR LPS3e
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
reversible: false
name: lipase, extracellular
is: SBO:0000176
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_839a85f9_8121_4152_a721_7bff697a4c6a
has only substance units: false
boundary condition: true
name: NIT2
type: Species
constant: false
is: SBO:0000252
is: Q9NQR4
initial concentration: NaN
is encoded by: hsa:56954
initial amount: NaN

metaM ksi pre1 g
type: Species
constant: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 1
is: HMDB00175
boundary condition: false
is: CHEBI:58053
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00130

metaR r2471
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
reactant: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
is: SBO:0000185

metaR KSII CORE2tly
fast: false
reactant: MODEL1310110060#
reversible: false
product: MODEL1310110060#
is: SBO:0000185
name: keratan sulfate II (core 2) transport, extracellular to lysosome
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM apoC Lys m
is: CHEBI:32551
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0
is: HMDB00182
initial concentration: 1.0
name: Apocarboxylase (Lys residue)
is: SBO:0000247

metaM HC00591 c
is: CHEBI:16769
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_988f90e5_49e3_43a6_86cf_68d0817008f8
initial concentration: NaN
type: Species
is encoded by: hsa:3145
initial amount: NaN
has only substance units: false
name: HMBS
boundary condition: true
constant: false
is: P08397
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_4bf01253_d491_4564_a78c_5a86cab2312c
name: GGT2
is encoded by: hsa:728441
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_07a025ee_613d_4c1b_8d17_4aa892dbff0a
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:AA021081
name: _AA021081_1_r
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a4c643b5_8fc0_45e7_8b9b_264dfafd8ceb
is: SBO:0000252
is: Q9HBH5
is encoded by: hsa:57665
constant: false
boundary condition: true
name: RDH14
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_49a25a47_4809_438b_931f_941a934474e2
constant: false
initial concentration: NaN
is: P07205
name: PGK2
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5232

http://identifiers.org/biomodels.db/MODEL1310110060#_17243548_79c5_40e9_bb8a_fd560db96870
is: SBO:0000252
constant: false
name: ATG9B
is encoded by: hsa:285973
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q674R7
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_1db439de_1d8c_41db_9d80_9b3bc4344567
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:788
constant: false
type: Species
name: SLC25A20
is: O43772
boundary condition: true
is: SBO:0000252

metaR r0960
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reversible: true

metaR CDPDAGtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction
is described by: ECO:0000000
name: intracellular transport
product: MODEL1310110060#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true

metaR r0456
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.32
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110060#_1eff8744_efcd_49b0_b35c_3ae56c7096de
type: Species
constant: false
is: P08319
has only substance units: false
initial amount: NaN
name: ADH4
is encoded by: hsa:127
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR FAOXC2251836m
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
fast: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
name: Beta oxidation of fatty acid
is: SBO:0000176
reactant: MODEL1310110060#
modifier: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

http://identifiers.org/biomodels.db/MODEL1310110060#_d427a313_2971_4fcb_88b8_ff66bd2ee30b
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC4A9
constant: false
is encoded by: hsa:83697
is: E9PDK1
boundary condition: true
is: SBO:0000252

metaM ppi x
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
has only substance units: false
boundary condition: false
is: C00013
name: Diphosphate
is: CHEBI:33019
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_b2bed5d7_974d_4dbe_adc0_ef27cb6e7aba
constant: false
is encoded by: hsa:93034
is: SBO:0000252
initial concentration: NaN
type: Species
name: NT5C1B
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q96P26

http://identifiers.org/biomodels.db/MODEL1310110060#_f9c6f642_9ae1_42b6_b03e_36e12526acce
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6535
initial amount: NaN
initial concentration: NaN
constant: false
is: B4DIA3
type: Species
name: SLC6A8

metaR 3MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: Transport of 3-methyl-2-oxopentanoate
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
is described by: ECO:0000134
reversible: true
type: Reaction
reactant: MODEL1310110060#

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_a4e4e950_9967_4786_b0f1_9188a273f0d3
is: E9KL44
type: Species
boundary condition: true
has only substance units: false
constant: false
name: HADHA
is: SBO:0000252
is encoded by: hsa:3030
initial concentration: NaN
initial amount: NaN

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_48ead884_391a_4226_8886_0a80b7a19905
initial amount: NaN
is encoded by: hsa:AA854479
name: _AA854479_1_m
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaR HSD3A2r
is: SBO:0000176
kinetic law: MODEL1310110060#
type: Reaction
fast: false
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ

metaM Rtotalcoa c
is: HMDB01448
type: Species
initial concentration: 1.0
is: CHEBI:16189
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: SBO:0000247
name: R total Coenzyme A

metaR r1434
is described by: ECO:0000000
reversible: false
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
name: Transport reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction

metaM ump n
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00288
name: UMP(2-)
has only substance units: false
type: Species
is: CHEBI:57865
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

http://identifiers.org/biomodels.db/MODEL1310110060#_4a2b9970_a311_4a42_96da_956cfd7b6f0b
initial amount: NaN
is encoded by: hsa:9962
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC23A2

http://identifiers.org/biomodels.db/MODEL1310110060#_d23dd2b1_302c_43bc_b867_1f101bebad9f
boundary condition: true
is: SBO:0000252
is: Q16836
name: HADH
is encoded by: hsa:3033
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_994660d1_ee02_41d2_88d9_ed2886b68f5d
is encoded by: hsa:8875
is: SBO:0000297
name: VNN3:VNN2:VNN1
has part: O95498
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:55350

metaR FAOXC140
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
fast: false
name: Beta oxidation of long chain fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176

metaM bildglcur c
is: HMDB03325
is: CHEBI:58471
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
constant: false

metaM gullac r
is: SBO:0000247
is: CHEBI:17587
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03466
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
name: L-gulono-1,4-lactone

http://identifiers.org/biomodels.db/MODEL1310110060#_b8c33fe8_2de9_4b3c_b9c5_309e6511d86a
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AU149534
is: SBO:0000252
initial amount: NaN
name: _AU149534_1_c
boundary condition: true
constant: false

metaR r2119
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_fb478ca1_5f31_4a11_8b9a_9c9782349893
initial amount: NaN
has only substance units: false
boundary condition: true
name: _AD000092_1_c
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:AD000092

metaM ksii core2 deg9 l
is: HMDB00143
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 9
type: Species
is: SBO:0000247
notes: FORMULA: C30H50N3O20X CHARGE: 0
has only substance units: false

metaM ksii core4 pre6 g
type: Species
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C69H111N6O51SX CHARGE: -2
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 6
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR AG13T18g
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110060#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f95ac134_3eb1_473a_89c9_d0aa6ba763fa
is: P10619
boundary condition: true
type: Species
name: CTSA
is: SBO:0000252
constant: false
is encoded by: hsa:5476
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM q10 c
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial amount: NaN
is: HMDB01072
initial concentration: 1.0
type: Species
is: CHEBI:46245
has only substance units: false
is: SBO:0000247
boundary condition: false
name: ubiquinone-10

http://identifiers.org/biomodels.db/MODEL1310110060#_9ee789b6_003c_44ad_8adc_69d2e5ac103e
name: NUDT12
initial amount: NaN
is: Q9BQG2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:83594
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaM uacgam c
is: CHEBI:57705
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
boundary condition: false
type: Species
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_f2de2862_f776_4403_bbbd_9ca51cef3031
name: ALDH3B2
is: P48448
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:222
initial concentration: NaN
type: Species
initial amount: NaN

metaR CHOLtn
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reactant: MODEL1310110060#
is described by: ECO:0000000
name: Choline transport, nuclear through pores
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: true

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR HSAT2ly
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110060#
is: SBO:0000185

metaR r0450
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110060#

metaR r1656
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
reversible: true

metaR r2320
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_573ca147_2429_4e09_9193_22f1e22e362f
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6470
is: SBO:0000252
name: SHMT1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f3b7d3c5_05e4_41d7_a939_7f4976423efb
name: RHBG
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:57127
has only substance units: false
is: SBO:0000252
is: Q9H310
type: Species
boundary condition: true

metaR GLYCTO1p
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000269
fast: false
name: Glycolate oxidase, peroxisome
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.3.15
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
kinetic law: MODEL1310110060#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_9d9d0caa_bfaa_4b05_b431_2315eb0bd3e2
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: E7EPA7
name: TKT
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7086

http://identifiers.org/biomodels.db/MODEL1310110060#_8a37866d_15d9_4253_b096_7de9f2c632fb
is encoded by: hsa:83884
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q9BXI2
initial amount: NaN
constant: false
name: SLC25A2

metaR UROLACer
name: uronolactonase, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110060#

metaM itacon m
has only substance units: false
boundary condition: false
type: Species
is: HMDB02092
initial amount: NaN
name: itaconate(2-)
constant: false
is: CHEBI:17240
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial concentration: 1.0
is: SBO:0000247

metaR r2118
fast: false
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_9fa7cd3c_beb5_4e78_9851_64db4ba40e13
type: Species
initial concentration: NaN
is: O95169
is: SBO:0000252
name: NDUFB8
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4714

metaM dttp n
is: C00459
initial amount: NaN
is: CHEBI:37568
boundary condition: false
is: HMDB01342
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
name: dTTP
is: SBO:0000247

metaM ppi r
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
is: CHEBI:33019
has only substance units: false
name: Diphosphate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00013
is: SBO:0000247
type: Species
constant: false

metaM guln r
has only substance units: false
constant: false
type: Species
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
initial amount: NaN
is: CHEBI:13115
name: L-gulonate
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM ump g
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: UMP(2-)
is: CHEBI:57865
is: HMDB00288
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaM ksi pre28 g
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00175
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 28
is: SBO:0000247
is: CHEBI:58053
boundary condition: false
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110060#_50b61f03_b8f2_4db9_98bf_a42497b94e15
initial concentration: NaN
is: E2QRH8
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: PLCB4
has only substance units: false
initial amount: NaN
is encoded by: hsa:5332

metaM triodthy c
is: HMDB00265
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18258

metaR 3MOBt2im
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
fast: false

metaM leuktrB4 e
name: leukotriene B4(1-)
is: HMDB01085
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57461
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165

http://identifiers.org/biomodels.db/MODEL1310110060#_4f29eb8d_0924_403a_b601_601b55b36266
is: Q9H845
type: Species
is encoded by: hsa:28976
is: SBO:0000252
initial concentration: NaN
name: ACAD9
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_169a5e0d_280b_4841_b8cf_e4ee443d1710
constant: false
boundary condition: true
is encoded by: hsa:6799
has only substance units: false
is: SBO:0000252
type: Species
name: SULT1A2
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_b6df6e3b_07be_44e0_8f64_60a35c136521
constant: false
name: ACOX1
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q15067
is encoded by: hsa:51
is: SBO:0000252

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR DOLASNT Uer
type: Reaction
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
is: SBO:0000176
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.119
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110060#
reactant: MODEL1310110060#

metaM nm4masn g
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C54H90N3O40X CHARGE: 0
is: C05882
has only substance units: false
initial concentration: 1.0
type: Species
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

metaR PPAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
is described by: ECO:0000000
product: MODEL1310110060#
reversible: false
is: SBO:0000185
fast: false
name: Propionate transport, diffusion
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#

metaR r2321
fast: false
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaR r1010
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
name: Postulated transport reaction
reactant: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR r1701
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaR r1655
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#

metaM hmgcoa x
is: HMDB01375
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_e45969f9_d2f5_4a85_8b23_bfbf5c82128b
is encoded by: hsa:216
name: ALDH1A1
initial concentration: NaN
initial amount: NaN
is: P00352
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false

metaM dudp m
constant: false
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
initial concentration: 1.0
is: CHEBI:60471
is: SBO:0000247
name: dUDP(3-)

metaR MEOHtly
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NCD
is: SBO:0000185
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
name: Methanol transporter, lysosome
reversible: true
reactant: MODEL1310110060#

metaM q10 e
initial amount: NaN
name: ubiquinone-10
is: HMDB01072
initial concentration: 1.0
type: Species
is: CHEBI:46245
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_0979ec95_c421_48a5_b719_b0daf26e4825
boundary condition: true
is encoded by: hsa:29922
constant: false
is: SBO:0000252
name: NME7
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

metaR r2198
product: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR MG1er
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.106
product: MODEL1310110060#
is described by: ECO:0000000
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction
is: SBO:0000176
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110060#_b065b5e3_97a6_4091_b518_994cff725afa
boundary condition: true
type: Species
is: O75874
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: IDH1
initial concentration: NaN
is encoded by: hsa:3417

http://identifiers.org/biomodels.db/MODEL1310110060#_2b08d016_8822_494b_99c3_0bb8f030f6dc
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5831
is: A6NFM2
boundary condition: true
name: PYCR1
has only substance units: false
initial concentration: NaN

metaR r2513
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reactant: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_9597ddd5_6d7d_49c4_b7c0_211540f6f904
is: SBO:0000252
is encoded by: hsa:123041
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: SLC24A4
initial concentration: NaN
type: Species

metaR GALASE15ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110060#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal

metaM Rtotal2 e
type: Species
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB00244
name: R total 2 position
is: CHEBI:3554
boundary condition: false
is: C00255
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR NRPPHRSULT
fast: false
modifier: MODEL1310110060#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110060#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.8.2.1
name: Norepinephrine Sulfotransferase

metaR GALASE10ly
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110060#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110060#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_9ae19b10_96ab_4340_8cd7_f52a8cb19c8e
has only substance units: false
type: Species
is: Q96KJ9
initial amount: NaN
constant: false
is encoded by: hsa:84701
is: SBO:0000252
name: COX4I2
boundary condition: true
initial concentration: NaN

metaR NACHEX20ly
modifier: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
type: Reaction
fast: false
is described by: ECO:0000000

metaR r2322
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_28aac13d_ea4f_49ec_a7eb_119ced9dd253
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:R33828
is: SBO:0000252
initial amount: NaN
name: _R33828_1_c

http://identifiers.org/biomodels.db/MODEL1310110060#_84baaf9c_2047_489d_bf22_1d95cde03766
boundary condition: true
initial concentration: NaN
is: Q8WUM9
constant: false
initial amount: NaN
name: SLC20A1
is encoded by: hsa:6574
type: Species
has only substance units: false
is: SBO:0000252

metaR FK
is: SBO:0000176
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
modifier: MODEL1310110060#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.52
product: MODEL1310110060#
name: Fucokinase

metaM cysam c
type: Species
constant: false
is: CHEBI:58029
has only substance units: false
initial concentration: 1.0
name: cysteaminium
boundary condition: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: HMDB02991
is: SBO:0000247
initial amount: NaN

metaR GHMT2r
is: SBO:0000176
fast: false
name: glycine hydroxymethyltransferase, reversible
type: Reaction
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.1.2.1
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD

metaR r2199
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
fast: false
type: Reaction

metaR AKR1C41
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
reversible: false

metaM sT antigen g
boundary condition: false
type: Species
notes: FORMULA: C25H40N2O18X CHARGE: -1
is: SBO:0000247
is: CHEBI:16565
has only substance units: false
name: sialyl-T antigen
constant: false
initial amount: NaN
initial concentration: 1.0

metaM 13dampp c
initial concentration: 1.0
constant: false
is: SBO:0000247
name: trimethylenediaminium
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00002
type: Species
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: CHEBI:57484

http://identifiers.org/biomodels.db/MODEL1310110060#_9473417f_4395_4463_879f_2052279c9dcd
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: Q9NQU1
name: SLC26A6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:65010

metaM lald L c
name: (S)-lactaldehyde
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB03052
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
has only substance units: false
initial concentration: 1.0
is: CHEBI:18041
boundary condition: false
type: Species

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

metaR MI145PP
product: MODEL1310110060#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.86
name: inositol-1,4,5-trisphosphate 5-phosphatase
reactant: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.3.56
modifier: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false

metaR CYTK5n
name: cytidylate kinase (CMP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
fast: false
reversible: true
product: MODEL1310110060#
modifier: MODEL1310110060#

metaR DITPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true
name: dITP nuclear transport

metaR r1657
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR r2323
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_5ca4a9c0_e17e_4747_9556_d7b32e2cf75c
constant: false
type: Species
name: SDHB
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6390
boundary condition: true
is: P21912

http://identifiers.org/biomodels.db/MODEL1310110060#_712b79e9_3ac9_4f45_a482_380fc4ae9f83
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55229
constant: false
is: Q9NVE7
name: PANK4
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR PROSTGE2t
reversible: true
is: SBO:0000185
modifier: MODEL1310110060#
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110060#
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110060#_5d0c07fc_8f91_454d_bf36_d412645a2c8e
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P16499
is encoded by: hsa:5145
name: PDE6A
initial amount: NaN

metaR r2325
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110060#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM HC01162 c
type: Species
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
has only substance units: false
constant: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: CHEBI:58376
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_e764de6f_5071_444a_8d2b_e60d4ae42f2b
name: GALT
constant: false
is encoded by: hsa:2592
initial concentration: NaN
has only substance units: false
is: E7ET32
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaR DM T antigen g
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_5d9239cf_76ad_4e7d_a613_12bd819a8b30
constant: false
name: ALDH3B2
is: P48448
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:222
boundary condition: true

metaM maltpt e
is: http://identifiers.org/pubchem.compound/5141
boundary condition: false
is: C02052
is: HMDB01296
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
name: maltopentaose
type: Species
initial amount: NaN
initial concentration: 1.0

metaM ile L c
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191
constant: false
name: L-isoleucine
is: HMDB00172
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_b22c859c_460a_4a4c_b2cb_34866f82522b
name: GGT5
is encoded by: hsa:2687
type: Species
initial concentration: NaN
is: P36269
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_bc93500f_9431_4bee_9359_04e71982c65e
name: DGKB
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1607
has only substance units: false
is: Q9Y6T7
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR r2114
reversible: true
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_4d122191_2667_435d_94ec_05eac7b234f5
name: SLC2A9
is encoded by: hsa:56606
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q9NRM0
type: Species
constant: false
initial amount: NaN

metaR UMPK4
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110060#
name: UMP kinase (GTP)
modifier: MODEL1310110060#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_b692a3b6_1754_464a_b2ec_081e93c3081b
initial concentration: NaN
name: PDE5A
is: G5E9C5
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:8654
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_93fdd4da_ba79_4fe7_b27f_ed30a0197895
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6576
has only substance units: false
initial amount: NaN
is: D9HTE9
initial concentration: NaN
name: SLC25A1

metaM ppi n
boundary condition: false
is: HMDB00250
is: CHEBI:33019
initial concentration: 1.0
constant: false
type: Species
name: diphosphate(3-)
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR RE1527M
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1527

metaM inost c
has only substance units: false
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
is: SBO:0000247
name: myo-inositol
is: CHEBI:17268
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaM gal l
constant: false
initial amount: NaN
is: SBO:0000247
name: D-galactose
type: Species
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: HMDB00143
has only substance units: false

metaR r0801
reversible: true
kinetic law: MODEL1310110060#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
modifier: MODEL1310110060#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000185
reactant: MODEL1310110060#

metaR r2324
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110060#
reversible: true
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

metaR FACOAL204
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
fast: false
type: Reaction
reversible: true

metaR r0672
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110060#
reversible: true
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
type: Reaction
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_eb00f1b5_073c_442d_abf9_6797e431b184
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:229
is: P05062
name: ALDOB
has only substance units: false

metaR r0208
is: SBO:0000176
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
reversible: true
is version of: http://identifiers.org/ec-code/4.4.1.1
product: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false

metaR COAtr
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
name: COA transporter, endoplasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR GLCAASE9ly
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
name: beta-glucuronidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110060#_768484a0_7b54_43da_a404_794cd83571ac
type: Species
is encoded by: hsa:53354
boundary condition: true
has only substance units: false
constant: false
name: PANK1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR RE2655R
is described by: ECO:0000000
name: RE2655
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_2981f5aa_b5a2_4a40_801c_73d6efecd6aa
has only substance units: false
constant: false
name: HMGCS1
boundary condition: true
initial amount: NaN
is encoded by: hsa:3157
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q01581

metaR UMPK3
type: Reaction
is: SBO:0000176
name: UMP kinase (UTP)
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110060#
reversible: true
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110060#
product: MODEL1310110060#

metaR FAEL183
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is described by: ECO:0000000
modifier: MODEL1310110060#
fast: false
name: fatty-acyl-CoA elongation (n-C18:3CoA)
reversible: false
kinetic law: MODEL1310110060#

metaR r2115
fast: false
modifier: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_7f7f7634_13c5_4fee_84ac_6512b4045f99
initial concentration: NaN
initial amount: NaN
is: B4DG68
is encoded by: hsa:4842
is: SBO:0000252
has only substance units: false
boundary condition: true
name: NOS1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_702ab92a_12a6_4dc4_902f_fc22c62a1c16
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P02730
name: SLC4A1
type: Species
is encoded by: hsa:6521

metaM m5masnC g
initial amount: NaN
is: HMDB00968
initial concentration: 1.0
type: Species
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: CHEBI:58282
boundary condition: false
constant: false
is: SBO:0000247
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_26bd3321_2202_497d_93b6_1c86e4c7dcf2
initial amount: NaN
is: SBO:0000252
is: P30566
boundary condition: true
name: ADSL
is encoded by: hsa:158
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaR GLCMter
product: MODEL1310110060#
name: glucose transport via membrane vesicle
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
kinetic law: MODEL1310110060#

metaM ppi m
initial concentration: 1.0
is: C00013
initial amount: NaN
is: SBO:0000247
is: HMDB00250
has only substance units: false
boundary condition: false
constant: false
type: Species
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019

metaM ksi deg7 l
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
constant: false
is: HMDB01354
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I, degradation product 7
has only substance units: false
is: CHEBI:57455
type: Species

metaR MALtm
name: malate transport, mitochondrial
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
kinetic law: MODEL1310110060#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110060#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_5111648f_fcbc_4ded_b1c5_cfbb534cfcf2
name: SLC22A5
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6584
is: SBO:0000252
is: O76082
constant: false
initial concentration: NaN

metaR CHOLATEt
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
name: cholate transport via bicarbonate countertransport
is: SBO:0000185
reactant: MODEL1310110060#

metaR ADA
name: Adenosine deaminase
is: SBO:0000176
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
reversible: false

metaR G12MT2 U
product: MODEL1310110060#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_26fb5b37_5f80_4401_86e5_464b6fb7ad34
is encoded by: hsa:1376
is: P23786
has only substance units: false
type: Species
constant: false
boundary condition: true
name: CPT2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR GALK
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.157
reactant: MODEL1310110060#
reversible: false
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
name: galactokinase
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.6
fast: false

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaR MALT
notes: GENE_ASSOCIATION: (2595.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:12370436,PMID:7018580 NOTES:IF
reactant: MODEL1310110060#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.20
is: SBO:0000176
product: MODEL1310110060#
modifier: MODEL1310110060#
reversible: false
name: alpha-glucosidase
type: Reaction
kinetic law: MODEL1310110060#

metaR GALASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR BHBt
fast: false
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport

metaR RTOTAL3FATPc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_e2b79ef3_3611_4eaf_affe_01b02b4e4535
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SULT1A1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6817

metaR r2327
fast: false
reversible: true
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110060#

metaR URIt5le
reactant: MODEL1310110060#
type: Reaction
reversible: false
modifier: MODEL1310110060#
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is: SBO:0000185

metaR r2116
type: Reaction
reactant: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaR HSD11B2r
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.146
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
name: 11-beta-hydroxysteroid dehydrogenase type 2
reversible: true
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#

metaM triodthy e
boundary condition: false
type: Species
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: SBO:0000247
is: HMDB00265
is: CHEBI:18258

metaM ksi deg23 l
name: keratan sulfate I, degradation product 23
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
is: HMDB00143
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110060#_afa80c04_d3cc_4efb_82cf_1b58ee1dfb25
boundary condition: true
has only substance units: false
name: _AI091231_1_c
is encoded by: hsa:AI091231
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaM hexdicoa r
initial amount: NaN
is: HMDB00672
has only substance units: false
name: hexadecanedioylcoa
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: C08260

http://identifiers.org/biomodels.db/MODEL1310110060#_bff83530_17b0_44ef_b9ce_82c48c0bd923
is: SBO:0000252
is: Q5JWV8
initial concentration: NaN
constant: false
boundary condition: true
name: ACSL4
is encoded by: hsa:2182
type: Species
initial amount: NaN
has only substance units: false

metaR UMPK6
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: UMP kinase (dCTP)
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM leuktrB4 c
is: SBO:0000247
boundary condition: false
is: HMDB01085
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
has only substance units: false
name: leukotriene B4(1-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_fbfb6681_f1f3_4adc_92ea_46f2900dd5df
initial concentration: NaN
is encoded by: hsa:5152
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PDE9A
type: Species
has only substance units: false
constant: false

metaM prostgd2 e
type: Species
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
is: CHEBI:57406
initial amount: NaN
name: prostaglandin D2(1-)
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_7422a8bc_b266_4392_acde_9953fe51c4ee
constant: false
name: RDH13
initial amount: NaN
boundary condition: true
is encoded by: hsa:112724
is: B3KVA3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaM lac L e
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00190
constant: false
is: CHEBI:16651
has only substance units: false
name: (S)-lactate

http://identifiers.org/biomodels.db/MODEL1310110060#_66209678_fa6a_4fc9_bd02_6a001be85091
initial concentration: NaN
constant: false
is encoded by: hsa:8776
type: Species
has only substance units: false
name: MTMR1
is: Q13613
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_bd9c4054_def7_46b9_ae5c_62717e8d8f69
is encoded by: hsa:218
initial amount: NaN
is: SBO:0000252
name: ALDH3A1
constant: false
is: P30838
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_a0fe3ab1_78c3_443d_9a61_934b2671a359
boundary condition: true
is: P34059
has only substance units: false
name: GALNS
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:2588
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_318e57bb_50e3_4aad_ba97_536e79c1b61e
initial amount: NaN
initial concentration: NaN
name: PPCDC
is encoded by: hsa:60490
is: Q96CD2
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false

metaM man1p c
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
type: Species
is: HMDB06330
has only substance units: false
constant: false
initial concentration: 1.0
name: D-Mannose 1-phosphate
boundary condition: false
is: SBO:0000247
is: CHEBI:35374

http://identifiers.org/biomodels.db/MODEL1310110060#_1c108eee_20d3_4088_b2c7_e60799412d4c
type: Species
boundary condition: true
initial concentration: NaN
is: O75610
name: LEFTY1
is encoded by: hsa:10637
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR r0287
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
is described by: ECO:0000000
product: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_2781e78f_0345_4fd5_9e08_02aa021e83ad
name: CPOX
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: P36551
is encoded by: hsa:1371
boundary condition: true

metaR COAtp
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction
name: coenzyme A transport, peroxisomal
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM ksii core4 pre10 g
has only substance units: false
is: CHEBI:28067
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
constant: false
is: SBO:0000247

metaR URCN
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.49
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000269
fast: false
name: URCN

metaR r2326
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110060#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_d89092b0_9922_4b6f_a916_9175cd205586
boundary condition: true
name: ELOVL4
initial concentration: NaN
constant: false
is: Q9GZR5
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6785

http://identifiers.org/biomodels.db/MODEL1310110060#_d8109a76_a77c_4c0d_aafb_601b9a6f4f0e
is: Q9H2X9
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:57468
name: SLC12A5
boundary condition: true

metaR UMPK5
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dATP)
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176

metaM prostge2 c
boundary condition: false
name: prostaglandin E2(1-)
constant: false
is: CHEBI:606564
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: HMDB01220
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f76fc6dd_f9ef_4e4e_bf1f_d1b3ccd230c6
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:389015
name: SLC9A4
is: Q6AI14
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR GPDDA1
reversible: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
product: MODEL1310110060#

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR r2117
product: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110060#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110060#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_2e603241_5b67_4b25_9804_f807afe99110
initial amount: NaN
boundary condition: true
name: FOLR1
is encoded by: hsa:2348
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM thcholstoic c
is: SBO:0000247
is: CHEBI:18402
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
initial amount: NaN

metaR TRIODTHYt2
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
reversible: true
modifier: MODEL1310110060#
fast: false
name: T3 transport via facilitated diffusion
is described by: ECO:0000269
product: MODEL1310110060#

metaM crn x
name: L-Carnitine
is: C00318
has only substance units: false
is: CHEBI:16347
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
constant: false
is: HMDB00062
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_ffb5a963_ba70_40fe_9fb8_21668b999a68
type: Species
boundary condition: true
is encoded by: hsa:10841
initial concentration: NaN
name: FTCD
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR r1018
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110060#
name: Transport reaction
type: Reaction
is described by: ECO:0000000

metaR r2329
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110060#
fast: false

metaM glutcoa m
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
name: glutaryl-CoA(5-)
type: Species
constant: false
is: CHEBI:57378
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01339
boundary condition: false
has only substance units: false

metaR DDCRNe
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaM xoldioloneh c
initial concentration: 1.0
is: HMDB06887
is: CHEBI:2288
boundary condition: false
is: SBO:0000247
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
constant: false
type: Species
has only substance units: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
initial amount: NaN

metaM 2mp2coa m
initial amount: NaN
initial concentration: 1.0
name: 2-Methylprop-2-enoyl-CoA
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: HMDB01011
constant: false
is: CHEBI:27754
has only substance units: false

metaR r0899
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
reversible: true
reactant: MODEL1310110060#
name: Amino acid transporter ATB0+ Facilitated diffusion
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_eff85f40_6651_4e72_b2ce_6c8f22b820c0
name: CPT1B
boundary condition: true
is: B7Z5T8
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1375
constant: false
initial concentration: NaN
has only substance units: false

metaM gal1p c
type: Species
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
has only substance units: false
is: CHEBI:58336
constant: false
is: HMDB00645
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
initial amount: NaN
initial concentration: 1.0

metaR SCPx
type: Reaction
reversible: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.176
fast: false
is: SBO:0000176
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
is described by: ECO:0000269
name: peroxisomal thiolase 2
modifier: MODEL1310110060#

metaR r0391
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:

metaR GLCAASE1ly
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110060#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is: SBO:0000176
reversible: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_6590b997_944f_43be_84ee_664ad566ba41
initial concentration: NaN
is encoded by: hsa:6487
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: ST3GAL3
initial amount: NaN

metaM hmgcoa m
boundary condition: false
is: CHEBI:15467
initial concentration: 1.0
is: HMDB01375
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
type: Species
name: Hydroxymethylglutaryl-CoA
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM m4masn g
is: C05881
constant: false
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
notes: FORMULA: C46H77N2O35X CHARGE: 0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

metaR COAtm
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110060#
name: CoA transporter
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
fast: false
product: MODEL1310110060#

metaR r2110
product: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110060#_e517d1e6_5f24_46f4_80d1_36cc111db045
constant: false
boundary condition: true
is: Q02153
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: GUCY1B3
type: Species
is encoded by: hsa:2983

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaM dgchol c
constant: false
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
boundary condition: false
type: Species
is: HMDB00637
has only substance units: false
name: glycochenodeoxycholate
is: CHEBI:36252
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_d5e19d30_d49b_43e6_b548_9c265c5f9535
initial amount: NaN
name: NDUFA6
is: P56556
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4700
boundary condition: true
constant: false
has only substance units: false

metaR NDPK7n
reversible: true
product: MODEL1310110060#
fast: false
type: Reaction
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
kinetic law: MODEL1310110060#
is: SBO:0000176

metaR COAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110060#
name: coenzyme A transport, nuclear
type: Reaction
reactant: MODEL1310110060#

metaM 4abutn m
initial amount: NaN
is: CHEBI:58264
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01080
initial concentration: 1.0
name: 4-ammoniobutanal
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaM gdpfuc c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: CHEBI:57984
is: HMDB01095

metaR INSt
is: SBO:0000185
name: Inosine transport (diffusion)
type: Reaction
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
is described by: ECO:0000269
fast: false
reversible: true

metaM lcts e
is: C00243
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
name: Lactose
is: CHEBI:17716
initial concentration: 1.0
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: HMDB00186
has only substance units: false

metaR MI145PK
is version of: http://identifiers.org/ec-code/2.7.1.127
kinetic law: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#
name: inositol-1,4,5-trisphosphate 3-kinase
fast: false
reversible: false
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD

metaM mn l
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
name: beta-1,4-mannose-N-acetylglucosamine
boundary condition: false
is: HMDB06535
constant: false
type: Species
initial amount: NaN
is: SBO:0000247

metaR r0390
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#

metaR r2007
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR RE0958E
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
type: Reaction
name: RE0958
fast: false

metaR r2111
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110060#

metaR UMPK7
is: SBO:0000176
modifier: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is described by: ECO:0000269
name: UMP kinase (dGTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110060#_27f30967_0d44_47f1_a6e0_c119e91b2904
initial amount: NaN
has only substance units: false
name: ALDH3A1
constant: false
type: Species
is: P30838
is: SBO:0000252
is encoded by: hsa:218
boundary condition: true
initial concentration: NaN

metaM prostge2 e
type: Species
is: CHEBI:606564
boundary condition: false
name: prostaglandin E2(1-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01220
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
has only substance units: false
constant: false

metaM adrn e
boundary condition: false
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
name: adrenic acid
constant: false
is: CHEBI:53487
initial amount: NaN
type: Species
is: HMDB02226
initial concentration: 1.0

metaM mi13p c
is: HMDB06234
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
initial concentration: 1.0
is: SBO:0000247
name: 1D-myo-Inositol 1,3-bisphosphate
is: CHEBI:18225
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a3cdeef9_0400_44ca_b431_5bf0f6fa1ad2
constant: false
boundary condition: true
initial concentration: NaN
name: _AA278423_1_m
is: SBO:0000252
is encoded by: hsa:AA278423
initial amount: NaN
has only substance units: false
type: Species

metaM ala B c
is: CHEBI:16958
is: SBO:0000247
has only substance units: false
is: HMDB00056
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
type: Species

metaM mlthf m
name: 5,10-Methylenetetrahydrofolate
boundary condition: false
is: CHEBI:15636
is: SBO:0000247
is: C00143
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
is: HMDB01533
type: Species
initial amount: NaN

metaM xan c
is: C00385
constant: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
boundary condition: false
name: Xanthine
has only substance units: false
is: CHEBI:17712
is: SBO:0000247
initial concentration: 1.0
is: HMDB00292
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_1c8bda85_5e5f_473a_abea_f1692d3c9390
initial concentration: NaN
name: DUT
constant: false
has only substance units: false
boundary condition: true
is: P33316
type: Species
is: SBO:0000252
is encoded by: hsa:1854
initial amount: NaN

metaR r0310
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
product: MODEL1310110060#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaM mmcoa R m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
name: (R)-methylmalonyl-CoA(5-)
constant: false
boundary condition: false
type: Species
is: HMDB01269
is: SBO:0000247
initial amount: NaN
is: CHEBI:57326
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_9c44edd4_e1a7_4b89_96f6_39a8e190b3c4
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: NDUFS4
has only substance units: false
boundary condition: true
is encoded by: hsa:4724
is: O43181

http://identifiers.org/biomodels.db/MODEL1310110060#_639947b2_6b30_4590_9ee3_fb99e1ceafc7
is encoded by: hsa:5151
initial amount: NaN
is: SBO:0000252
is: H0YMZ7
boundary condition: true
name: PDE8A
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaM ile L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:17191
name: L-isoleucine
is: HMDB00172

metaR r2112
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaM dadp c
initial amount: NaN
initial concentration: 1.0
is: HMDB01508
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57667
is: C00206
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
name: dADP

metaM ksii core2 deg3 l
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00143
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 3
is: CHEBI:12936
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
boundary condition: false
type: Species

metaR r1019
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
name: Postulated transport reaction

metaR r1164
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110060#
name: EC:2.3.1.26
reactant: MODEL1310110060#

metaR ACALDt
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
name: acetaldehyde reversible transport
is: SBO:0000185
fast: false
reversible: true

metaR RE3244R
type: Reaction
is: SBO:0000176
reactant: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
name: RE3244
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaM lys L x
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:32551
name: L-lysinium(1+)
constant: false
is: SBO:0000247
is: HMDB00182
initial concentration: 1.0
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

metaR r0311
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110060#

metaM ksi pre22 g
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00175
is: C00130
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 22
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_5df230e6_4f2f_457b_97e5_9e89a4106288
name: PECR
is: Q9BY49
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:55825
boundary condition: true
is: SBO:0000252

metaM idour l
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
is: CHEBI:21338
initial amount: NaN
name: L-iduronate
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_9c0dc774_3ee4_4c91_b5af_b51da4b941b1
name: ACLY
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:47
is: P53396
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaM ala B e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
is: CHEBI:16958
is: HMDB00056
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: beta-alanine

metaR r2113
modifier: MODEL1310110060#
fast: false
type: Reaction
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185

metaR RETI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reversible: true
name: retinol isomerase (9-cis)
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
type: Reaction
is described by: ECO:0000000

metaM adrn c
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
name: adrenic acid
is: SBO:0000247
is: CHEBI:53487
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false

metaM HC01397 x
is: CHEBI:27402
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258

http://identifiers.org/biomodels.db/MODEL1310110060#_1e050570_3f23_45b7_a593_c09cdbdb6c5c
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: B3GNT8
initial amount: NaN
is encoded by: hsa:374907

http://identifiers.org/biomodels.db/MODEL1310110060#_f4118591_09e0_4c82_ae1f_4aa017d25c17
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4537
is: SBO:0000252
name: ND3
is: P03897
has only substance units: false

metaR CITt4 4
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
name: citrate transport via sodium symport
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
is: SBO:0000185

metaR r2005
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_b07ad049_88aa_4ddf_9277_0916b4cef43c
initial concentration: NaN
name: SLC5A8
has only substance units: false
is: SBO:0000252
is: Q8N695
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:160728
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_ca564b64_cd4f_4729_89a0_69d7e0c580b6
type: Species
is encoded by: hsa:231
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P15121
constant: false
name: AKR1B1
boundary condition: true
initial concentration: NaN

metaR RETI1
is: SBO:0000176
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
name: retinol isomerase (11-cis)
reversible: true
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_8fd6704a_9fd7_4008_8fb6_2203b1e8dea9
has only substance units: false
is: O43674
name: NDUFB5
boundary condition: true
is encoded by: hsa:4711
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR DOLMANP Uter
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
name: dolichol-phosphate mannose flippase (uterus)
fast: false

metaR FUMtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000269
modifier: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
name: fumarate transport, mitochondrial

metaR r0051
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: true
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
kinetic law: MODEL1310110060#
is: SBO:0000176
fast: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR AMPtp
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reversible: true
is: SBO:0000185
name: AMP transporter, peroxisome
is described by: ECO:0000000

metaM gullac c
initial amount: NaN
is: HMDB03466
is: SBO:0000247
name: L-gulono-1,4-lactone
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
boundary condition: false
is: CHEBI:17587
type: Species
constant: false
has only substance units: false

metaR r1167
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110060#
name: EC:2.3.1.26
reversible: false

metaR CYTK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110060#
name: cytidylate kinase (dCMP)
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#

metaR GLNtN1
is described by: ECO:0000269
reactant: MODEL1310110060#
name: Glutamine transport (Na, H coupled)
reversible: true
kinetic law: MODEL1310110060#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110060#
modifier: MODEL1310110060#

metaR GLCNACASE3ly
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
is: SBO:0000176

metaR r0395
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaR r0679
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
modifier: MODEL1310110060#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
product: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_716a5f7c_7dca_4ec1_bcfd_8d5fe83411ca
initial amount: NaN
is encoded by: hsa:6534
name: SLC6A7
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: Q99884

metaR r1581
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM cytd e
is: C00475
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: HMDB00089
is: CHEBI:17562
boundary condition: false
has only substance units: false
name: Cytidine
initial amount: NaN

metaR S6TASE13ly
is described by: ECO:0000000
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM hexdicoa x
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial amount: NaN
is: HMDB04047
name: hexadecanedioylcoa
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C14143
is: SBO:0000247
type: Species

metaR r1580
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR ACt2m
is described by: ECO:0000000
product: MODEL1310110060#
name: acetate mitochondrial transport via proton symport
kinetic law: MODEL1310110060#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD

metaM ksi pre12 g
is: C00130
has only substance units: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 12
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
is: HMDB00175
type: Species
initial concentration: 1.0
constant: false

metaR S6T15g
product: MODEL1310110060#
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.8.2.21
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.8.2.17
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110060#

metaR r0281
fast: false
reversible: true
kinetic law: MODEL1310110060#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
product: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
reactant: MODEL1310110060#
is: SBO:0000176

metaM hs deg19 l
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: HMDB01352
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17180
type: Species
is: SBO:0000247
name: heparan sulfate, degradation product 19
initial amount: NaN
initial concentration: 1.0

metaM crn r
initial concentration: 1.0
constant: false
is: HMDB00062
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
is: CHEBI:16347
name: (R)-carnitine
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_5a2c4894_fc1b_47cd_b38f_68c4be3c8450
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: B7Z6S9
is encoded by: hsa:2629
boundary condition: true
constant: false
name: GBA

metaR BTNDm
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false
modifier: MODEL1310110060#
reactant: MODEL1310110060#
name: biotinidase (biotin), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
product: MODEL1310110060#

metaR ADKd
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is: SBO:0000176
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000269
name: adenylate kinase (d form)
product: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#

metaR CYTK4
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
name: cytidylate kinase (dCMP)(GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269

metaR DGK1
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: deoxyguanylate kinase (dGMP:ATP)
modifier: MODEL1310110060#
reversible: true

metaM xylt c
initial concentration: 1.0
name: xylitol
type: Species
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:17151
constant: false
is: HMDB02917

metaR FAOXC183806m
is: SBO:0000176
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: Beta oxidation of fatty acid
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM ppi e
is: CHEBI:33019
constant: false
is: C00013
is: SBO:0000247
initial concentration: 1.0
is: HMDB00250
name: Diphosphate
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_5445b65b_da62_4485_8c15_e05469155a64
initial concentration: NaN
boundary condition: true
name: AOC3
is: Q16853
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8639
type: Species
constant: false
initial amount: NaN

metaR r0394
product: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
fast: false
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_69053fc1_5cad_41ff_b042_b4de05a95d20
is: SBO:0000252
constant: false
name: ALG3
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:10195
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_47a97422_31d6_482d_8444_80f861891def
boundary condition: true
is: O76062
name: TM7SF2
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7108

metaR PROSTGE2t2
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110060#
reversible: true
is described by: ECO:0000269
name: prostaglandin uniport
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000185

metaR PPPG9tm
is: SBO:0000185
name: protoporphyrinogen IX mitochondrial transport
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_fe7048a7_19ed_4280_b711_fddb0cb359bd
is encoded by: hsa:1375
type: Species
is: SBO:0000252
name: CPT1B
constant: false
initial concentration: NaN
is: Q53FV7
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_9219c775_5cec_4620_80b1_26639122c294
is: P04745
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:277
constant: false
name: AMY1B
type: Species

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110060#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#

metaM pe hs c
is: SBO:0000247
initial concentration: 1.0
constant: false
name: pe_hs[c]
is: CHEBI:21338
is: HMDB02704
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: CHARGE: 0
has only substance units: false

metaR CITL
name: Citrate lyase
product: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR

metaR r0728
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_24bd35f0_6cab_4461_9953_7826819b0d0d
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: PDE10A
is: Q9Y233
is encoded by: hsa:10846

metaM retinal 11 cis c
type: Species
boundary condition: false
name: 11-cis-retinal
is: CHEBI:16066
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB02152
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: SBO:0000247

metaR EX nad LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide exchange
type: Reaction

metaR BACCL
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
modifier: MODEL1310110060#
product: MODEL1310110060#
name: biotin-[acetyl-CoA-carboxylase] ligase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110060#

metaM for c
constant: false
is: CHEBI:15740
boundary condition: false
name: Formate
is: C00058
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142

http://identifiers.org/biomodels.db/MODEL1310110060#_742d798b_2cf4_408a_bc17_f1c0e4cc70bd
is encoded by: hsa:4645
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9H6Y6
boundary condition: true
name: MYO5B
constant: false
initial amount: NaN

metaR r0393
type: Reaction
product: MODEL1310110060#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
fast: false
reversible: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_21ba9b4c_08d5_41e3_a283_b6450f8994e4
is: P21399
has only substance units: false
initial amount: NaN
boundary condition: true
name: ACO1
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:48

metaM udpg r
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: HMDB00286
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: CHEBI:58367

metaM nac c
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01488
is: C00253
has only substance units: false
notes: FORMULA: C6H4NO2 CHARGE: -1
constant: false
name: Nicotinate
is: CHEBI:0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_552dc19e_fd5a_4f13_b7e4_a1ecef53f393
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4191
is: P40926
has only substance units: false
boundary condition: true
name: MDH2
type: Species

metaR CYTK7
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
name: cytidylate kinase (CMP,UTP)
type: Reaction

metaM dhor S c
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
is: CHEBI:30864
constant: false
name: (S)-dihydroorotate
has only substance units: false
initial concentration: 1.0
is: HMDB03349

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_3a21ca3c_c357_403b_b91f_95813741a99a
is encoded by: hsa:3290
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: HSD11B1
has only substance units: false
is: P28845

metaM cytd c
initial amount: NaN
is: C00475
initial concentration: 1.0
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
is: SBO:0000247
constant: false
name: Cytidine
boundary condition: false
is: HMDB00089
is: CHEBI:17562

metaR DOPAt4 2 r
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110060#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110060#
is described by: ECO:0000269
kinetic law: MODEL1310110060#
type: Reaction
name: Dopamine reversible transport in via sodium symport (1:2)

metaM 4izp c
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01014
type: Species
is: CHEBI:57255
name: 4-Imidazolone-5-propanoate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
has only substance units: false

metaR r1500
fast: false
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
kinetic law: MODEL1310110060#
is: SBO:0000185
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_c38f2acf_8a94_47b5_8fd0_a37613131e5b
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:93034
initial amount: NaN
name: NT5C1B
is: B3KUK6
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_10e454b7_2152_49c5_80b9_9697c91eb359
initial concentration: NaN
type: Species
is: P17174
has only substance units: false
is: SBO:0000252
constant: false
name: GOT1
initial amount: NaN
is encoded by: hsa:2805
boundary condition: true

metaM mag hs e
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
name: monoacylglycerol 2
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:60479
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR DGULND
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110060#
name: dehydro-L-gulonate decarboxylase

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_f8ec38f9_7c39_42ff_b971_415de81a7ccd
constant: false
initial concentration: NaN
is: SBO:0000252
is: P42765
is encoded by: hsa:10449
has only substance units: false
type: Species
name: ACAA2
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_c383788a_6e28_4919_b708_77584bceab44
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: GALNT7
is: Q86SF2
boundary condition: true
has only substance units: false
is encoded by: hsa:51809
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_be16b0ee_b863_4352_b7a6_a52cc62708b6
initial concentration: NaN
is encoded by: hsa:4846
type: Species
constant: false
has only substance units: false
is: A0S0A7
name: NOS3
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r0392
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110060#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#

metaR G14T12g
fast: false
modifier: MODEL1310110060#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR XYLt
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
type: Reaction
product: MODEL1310110060#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reactant: MODEL1310110060#
name: D-xylose reversible transport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110060#_daaee965_e998_42e2_b4a7_88ff76e4ae92
has only substance units: false
initial concentration: NaN
is encoded by: hsa:131
is: P40394
is: SBO:0000252
initial amount: NaN
name: ADH7
constant: false
type: Species
boundary condition: true

metaR CYTK6
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (CMP,CTP)
is: SBO:0000176
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110060#

metaR r0202
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110060#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true

metaR O2Stx
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: superoxide anion transport via diffusion (peroxisome)

http://identifiers.org/biomodels.db/MODEL1310110060#_4b6a7fa7_ebf2_48ea_8ebc_a6e89201f9fe
initial amount: NaN
constant: false
name: GYG2
boundary condition: true
type: Species
is encoded by: hsa:8908
is: O15488
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM dgchol e
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
name: glycochenodeoxycholate
has only substance units: false
initial concentration: 1.0
is: HMDB00637
boundary condition: false
constant: false
is: CHEBI:36252
is: SBO:0000247
type: Species

metaR r0512
is: SBO:0000176
product: MODEL1310110060#
modifier: MODEL1310110060#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
kinetic law: MODEL1310110060#

metaR r0726
reversible: true
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110060#

metaR UMPK7n
name: UMP kinase (dGTP),nuclear
product: MODEL1310110060#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110060#
is described by: ECO:0000269

metaM HC01407 m
is: SBO:0000247
constant: false
is: CHEBI:28276
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: (S)-Hydroxyhexanoyl-CoA
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
initial concentration: 1.0

metaR BUTt2r
modifier: MODEL1310110060#
name: Butyrate transport via proton symport, reversible
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM 4abutn c
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: C00555
is: SBO:0000247
name: 4-Aminobutanal
is: HMDB01080
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58264

metaM lac L c
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
has only substance units: false
name: (S)-lactate
is: HMDB00190
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_850dc722_2a7e_4252_b34a_1145612b5aac
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM mescon m
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36986
name: Mesaconate
type: Species
is: HMDB00749
boundary condition: false
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+

metaM idour c
is: HMDB02704
is: SBO:0000247
is: CHEBI:21338
name: L-iduronate
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_90a1dba7_254c_4005_830e_ccf883c42b6c
name: GBA
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2629
is: B7Z5G2
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_e9fd633e_4689_46d5_a8b8_c811c0938df9
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: Q5QPH3
initial concentration: NaN
is encoded by: hsa:55902
name: ACSS2
type: Species
boundary condition: true

metaM g1m8masn r
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: C05875
notes: FORMULA: C76H127N2O60X CHARGE: 0
type: Species
has only substance units: false
is: SBO:0000247
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaM tag hs e
is: CHEBI:17855
is: SBO:0000247
initial amount: NaN
name: triglyceride
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
type: Species

metaR r1585
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_551f7319_813b_4e70_b4b1_14aeca1c8d47
is encoded by: hsa:80308
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: FLAD1

metaM ksi pre9 g
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
is: C00130
type: Species
initial amount: NaN
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
name: keratan sulfate I biosynthesis, precursor 9
has only substance units: false
constant: false
initial concentration: 1.0

metaR CYTK1
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#
fast: false
type: Reaction
reactant: MODEL1310110060#
name: cytidylate kinase (CMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_9a08ba89_a705_4d30_8ea0_cdd8a87e9aa8
has only substance units: false
type: Species
initial amount: NaN
name: PKM2
constant: false
initial concentration: NaN
is encoded by: hsa:5315
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_7cbdc7a1_57a9_4239_84ae_6f60a35dc032
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: HIBCH
is encoded by: hsa:26275
initial concentration: NaN
is: Q6NVY1

metaR ALAGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000304
name: L-alanine/glycine reversible exchange
modifier: MODEL1310110060#
product: MODEL1310110060#

metaR r0399
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
fast: false
product: MODEL1310110060#
modifier: MODEL1310110060#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
type: Reaction
reactant: MODEL1310110060#

metaM 3oddcoa m
name: 3-Oxododecanoyl-CoA
is: CHEBI:27868
type: Species
is: HMDB03937
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaM gltcho e
boundary condition: false
constant: false
name: beta glucan-taurocholic acid complex
initial amount: NaN
type: Species
notes: FORMULA: C1200026H2200045NO1100007S CHARGE: 0
is: HMDB00672
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C08260

metaM co c
type: Species
is: CHEBI:17245
initial amount: NaN
name: carbon monoxide
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: HMDB01361
is: SBO:0000247
constant: false
has only substance units: false

metaM crn m
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
is: HMDB00062
is: C00318
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16347
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR DADA
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
modifier: MODEL1310110060#
is: SBO:0000176
reversible: false
name: Deoxyadenosine deaminase
is described by: ECO:0000269
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_09dea55f_2dff_4d6e_88d2_ec5d9fb8d47b
constant: false
has only substance units: false
is encoded by: hsa:11136
is: P82251
initial amount: NaN
name: SLC7A9
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM 56dura c
name: 5,6-dihydrouracil
type: Species
is: HMDB00076
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15901
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_ea2fa5f0_e10e_49ff_9f3a_ec3098ab0405
has only substance units: false
is encoded by: hsa:2589
is: SBO:0000252
is: Q10472
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: GALNT1

http://identifiers.org/biomodels.db/MODEL1310110060#_0d519a48_7ff1_4cb5_86b7_682a332e59dc
is encoded by: hsa:2181
type: Species
initial amount: NaN
is: SBO:0000252
is: O95573
name: ACSL3
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true

metaR TRPt
product: MODEL1310110060#
fast: false
is described by: ECO:0000269
name: L-tryptophan transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
modifier: MODEL1310110060#
type: Reaction
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_5fdc0d41_3596_4457_b27d_290acb504660
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: O00754
name: MAN2B1
initial concentration: NaN
is encoded by: hsa:4125
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_291af5f4_7961_4378_ae23_577aee04e9c2
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110060#_8838fcb4_2ed9_4c1e_9878_58a633935f5c
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: P14618
is encoded by: hsa:5315
constant: false
type: Species
name: PKM2
is: SBO:0000252

metaR S2L2FN2M2MASNt
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
name: s2l2fn2m2masn transport, Golgi to extracellular

http://identifiers.org/biomodels.db/MODEL1310110060#_734037d0_0e62_4458_9473_ed49636ce34c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P06865
is encoded by: hsa:3073
boundary condition: true
name: HEXA
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_26ecb8bb_75e8_49af_bb32_7077987cc87c
boundary condition: true
initial amount: NaN
name: SLC16A3
is encoded by: hsa:9123
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is: O15427

metaM lys L m
name: L-lysinium(1+)
type: Species
has only substance units: false
is: CHEBI:32551
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
constant: false
is: HMDB00182

metaR GALU
kinetic law: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.9
name: UTP-glucose-1-phosphate uridylyltransferase
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y

metaM 4abutn e
name: 4-ammoniobutanal
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:58264
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR GALT
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
name: galactose-1-phosphate uridylyltransferase
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
modifier: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_508795f4_1b63_4e65_ad85_2d9b3f4f07c0
has only substance units: false
name: GALNT2
is: SBO:0000252
is: Q10471
is encoded by: hsa:2590
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR r0317
is: SBO:0000176
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR r1584
is: SBO:0000185
product: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110060#

metaR XOL7AONEtr
fast: false
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
reversible: true

metaR r0892
reversible: true
is: SBO:0000185
modifier: MODEL1310110060#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.2.27

metaM HC01397 m
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: CHEBI:27402
initial amount: NaN

metaM prostgd2 r
is: HMDB01403
is: CHEBI:57406
constant: false
initial amount: NaN
has only substance units: false
name: prostaglandin D2(1-)
type: Species
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_3764a500_041d_4a35_ba20_6fcde53f2191
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:AA614647
boundary condition: true
name: _AA614647_1_c
constant: false
initial amount: NaN
has only substance units: false

metaR r1954
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM c14dccoa x
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: HMDB04047
is: C14143
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
is: SBO:0000247
name: tetradecanedioylcoa

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR RE0512M
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
product: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE0512
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110060#_521d0e55_4a64_4532_b6be_598dd5645476
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9NSW9
is encoded by: hsa:6553
name: SLC9A5
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_95e101d2_9d79_4bac_bbfb_c79d6f2727ab
is: P47895
name: ALDH1A3
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:220
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM tag hs c
is: CHEBI:17855
constant: false
name: triglyceride
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
has only substance units: false

metaM inost e
type: Species
is: HMDB00211
is: CHEBI:17268
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: myo-inositol
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_5324a29e_522f_4676_ad92_7de7836bdf16
is encoded by: hsa:223
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: ALDH9A1
initial concentration: NaN
boundary condition: true
is: P49189

metaM hs deg22 l
is: HMDB02704
boundary condition: false
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: CHEBI:21338
notes: FORMULA: C37H56NO35S CHARGE: -3
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_7c318fb5_a5d6_4060_8d58_b93407628802
constant: false
is encoded by: hsa:4833
name: NME4
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: O00746

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM 1p3h5c m
is: SBO:0000247
initial amount: NaN
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: CHEBI:6151
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
constant: false
is: HMDB01369
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_0fcf9e0b_4cd9_43c1_ae63_1ef7e3a7f92c
is: P46721
is encoded by: hsa:6579
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: SLCO1A2

metaM lys L n
is: HMDB00182
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: L-lysinium(1+)
is: CHEBI:32551
constant: false

metaR UMPK2
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
name: UMP kinase (CTP)
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaM idour e
is: SBO:0000247
is: CHEBI:21338
name: L-iduronate
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
boundary condition: false
has only substance units: false
type: Species

metaM ala B m
initial concentration: 1.0
type: Species
is: CHEBI:16958
is: HMDB00056
initial amount: NaN
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

metaR BILGLCURtr
name: glucuronidated compound transport
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reversible: true
product: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is: SBO:0000185

metaR CYTK3
type: Reaction
kinetic law: MODEL1310110060#
fast: false
name: cytidylate kinase (CMP)(GTP)
modifier: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269

metaR r1583
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR DNDPt35m
product: MODEL1310110060#
reactant: MODEL1310110060#
name: dGDP transport via dADP antiport
modifier: MODEL1310110060#
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110060#

metaR 4NPHSULT
modifier: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
name: 4-Nitrophenol Sulfotransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
is: SBO:0000176
kinetic law: MODEL1310110060#
product: MODEL1310110060#

metaR NACHEX11ly
reactant: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: false
modifier: MODEL1310110060#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110060#_6f7a7e19_4a27_4552_afc7_7b6b58886b46
boundary condition: true
has only substance units: false
name: TKTL1
is: B7Z7I0
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8277
constant: false

metaM odecoa r
initial concentration: 1.0
has only substance units: false
is: HMDB01322
is: CHEBI:57387
type: Species
boundary condition: false
name: oleoyl-CoA(4-)
constant: false
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
initial amount: NaN

metaR ACt2r
type: Reaction
reactant: MODEL1310110060#
name: acetate reversible transport via proton symport
product: MODEL1310110060#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110060#_297d3b06_cffe_45fa_8df2_25f78e38c05a
is encoded by: hsa:2632
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q04446
constant: false
type: Species
name: GBE1

http://identifiers.org/biomodels.db/MODEL1310110060#_7e170abd_c55f_46be_bf00_2f40d0302470
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1376
type: Species
initial concentration: NaN
is: P23786
name: CPT2

metaM guln c
is: SBO:0000247
boundary condition: false
name: L-gulonate
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB03290
initial amount: NaN
is: CHEBI:13115
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800

metaM CE1944 c
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:36781
is: SBO:0000247
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
constant: false
name: 1-pyrrolinium
boundary condition: false

metaM uacgam r
constant: false
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
has only substance units: false
is: CHEBI:57705
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false

metaM co e
is: SBO:0000247
constant: false
is: HMDB01361
boundary condition: false
type: Species
is: CHEBI:17245
has only substance units: false
initial concentration: 1.0
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
name: carbon monoxide
initial amount: NaN

metaM xylt e
boundary condition: false
name: xylitol
initial amount: NaN
is: HMDB02917
is: CHEBI:17151
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_c330386e_d605_463c_99cb_3d4f71651b1d
name: SLC16A1
initial concentration: NaN
is: SBO:0000252
is: B4DKS0
has only substance units: false
is encoded by: hsa:6566
initial amount: NaN
constant: false
boundary condition: true
type: Species

metaR ACOAD1fm
reversible: false
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)

http://identifiers.org/biomodels.db/MODEL1310110060#_f1ee411c_4dfc_49c2_8733_b6498afb1177
boundary condition: true
name: NDUFA9
initial amount: NaN
is: SBO:0000252
type: Species
is: Q16795
is encoded by: hsa:4704
has only substance units: false
constant: false
initial concentration: NaN

metaM k c
constant: false
is: HMDB00586
initial concentration: 1.0
is: C00238
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
name: potassium
boundary condition: false
is: CHEBI:29103

metaM ahcys c
initial concentration: 1.0
is: SBO:0000247
is: C00021
is: HMDB00939
type: Species
has only substance units: false
is: CHEBI:16680
initial amount: NaN
name: S-Adenosyl-L-homocysteine
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
boundary condition: false

metaR CYTK2
reversible: true
name: cytidylate kinase (dCMP)
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
modifier: MODEL1310110060#

metaR C204CRNt
fast: false
name: arachidonic acid transport into the mitochondria
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
is described by: ECO:0000000
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_6d79c5ed_e81b_494c_91ec_1d2432a0cb49
is: SBO:0000252
name: CYBRD1
constant: false
type: Species
is encoded by: hsa:79901
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: B4DWD7

metaR r0722
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.3.12
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110060#
is: SBO:0000176
fast: false
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_f8eb4262_951e_43a4_8498_a4256494b25c
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: HEXB
is encoded by: hsa:3074
is: P07686

metaR URIt
is described by: ECO:0000269
fast: false
reversible: true
reactant: MODEL1310110060#
name: uridine facilated transport in cytosol
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
modifier: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_bd136b79_5e85_4433_a1ea_6289b385e617
name: ADH5
is encoded by: hsa:128
type: Species
boundary condition: true
is: Q6IRT1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaM dag hs c
constant: false
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

metaR APAT2rm
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/2.6.1.19
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_00ff7d3a_90f9_411d_aebc_155d682525bb
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: A6H8L5
name: LIPC
constant: false
type: Species
is encoded by: hsa:3990
initial amount: NaN
boundary condition: true

metaM ppi c
name: Diphosphate
is: SBO:0000247
is: C00013
boundary condition: false
type: Species
constant: false
is: CHEBI:0
notes: FORMULA: HO7P2 CHARGE: -3
is: HMDB00250
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR MI134P4P
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 4-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_0be8cb48_e424_4940_8d80_236e5fe0ccd6
has only substance units: false
boundary condition: true
is: B7Z2M9
type: Species
is: SBO:0000252
is encoded by: hsa:8525
constant: false
initial concentration: NaN
initial amount: NaN
name: DGKZ

http://identifiers.org/biomodels.db/MODEL1310110060#_cb71daa9_a696_43f0_a39e_e21301436375
has only substance units: false
name: COL4A3BP
constant: false
initial amount: NaN
is: Q9Y5P4
initial concentration: NaN
is encoded by: hsa:10087
type: Species
is: SBO:0000252
boundary condition: true

metaR HISSNAT5tc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1574
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_979a2ddc_a370_4363_82db_3da7e8469bb3
name: IMPA2
is: SBO:0000252
is encoded by: hsa:3613
constant: false
initial concentration: NaN
initial amount: NaN
is: O14732
boundary condition: true
type: Species
has only substance units: false

metaR r1642
modifier: MODEL1310110060#
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_5b578895_c800_44d1_b7d8_dfa23eb58e02
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:276
constant: false
is: SBO:0000252
is: Q6NSB3
name: AMY1A
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_db7c1194_9f49_4fca_81b7_6b758edbad76
initial amount: NaN
is: O43570
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:771
name: CA12
is: SBO:0000252
initial concentration: NaN

metaR DCK1n
type: Reaction
fast: false
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
name: Deoxycytidine kinase, nuclear (ATP)
is described by: ECO:0000269
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaR r1429
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Free diffusion

metaM mi134p c
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58414
initial concentration: 1.0
is: HMDB01143
has only substance units: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)

metaM 6pgl c
name: 6-phospho-D-glucono-1,5-lactone
initial concentration: 1.0
is: C01236
notes: FORMULA: C6H9O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: HMDB01127
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57955
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_0160dee6_85bd_4a63_855a_4ea9ccc37843
constant: false
has only substance units: false
boundary condition: true
name: _7359_1_c
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7359
initial concentration: NaN

metaR MM8Cg
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
is: SBO:0000176
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

metaM udpacgal c
is: SBO:0000247
is: HMDB00304
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
type: Species

metaM ctp m
boundary condition: false
has only substance units: false
is: HMDB00082
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37563
name: CTP(4-)
constant: false

metaR MCPST
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.1.2
modifier: MODEL1310110060#
name: 3-mercaptopyruvate sulfurtransferase
is described by: ECO:0000134
product: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
type: Reaction

metaR GK1
reactant: MODEL1310110060#
reversible: true
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
name: guanylate kinase (GMP:ATP)

http://identifiers.org/biomodels.db/MODEL1310110060#_f4bf86af_2b78_4662_9060_0984fdda331e
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:3939
is: SBO:0000252
type: Species
initial amount: NaN
is: P00338
name: LDHA

metaR SUCCTD
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_8326aac8_5d3e_4c33_a9e3_5c686cdd5a9e
initial amount: NaN
constant: false
is encoded by: hsa:100287639
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: _100287639_1_c

metaR r1575
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_dbb69618_e1cc_4910_84fe_c29bf9a44333
boundary condition: true
is: P09960
constant: false
type: Species
is encoded by: hsa:4048
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: LTA4H

metaR r1641
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DOLPMT2 Uer
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110060#
reversible: false
type: Reaction
reactant: MODEL1310110060#

metaR r0596
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4

metaM dpcoa c
initial amount: NaN
is: CHEBI:57328
is: SBO:0000247
constant: false
name: Dephospho-CoA
has only substance units: false
boundary condition: false
is: C00882
initial concentration: 1.0
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373

metaM 4hpro LT m
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:18095
name: trans-4-hydroxy-L-proline
boundary condition: false
is: HMDB00725
constant: false
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false

metaM nadh m
initial amount: NaN
is: SBO:0000247
is: C00004
constant: false
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
type: Species
boundary condition: false
is: HMDB01487
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_182ec3ac_b883_450d_8b2b_2a969d52bc24
is encoded by: hsa:6342
is: C9JC79
has only substance units: false
initial concentration: NaN
name: SCP2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaM orn c
is: HMDB00214
is: CHEBI:0
initial concentration: 1.0
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: Ornithine
initial amount: NaN
has only substance units: false

metaM ksii core2 deg8 l
is: CHEBI:12936
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00143
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 8

http://identifiers.org/biomodels.db/MODEL1310110060#_476c0974_310c_4f38_ba5b_1bb25f2e6319
name: CA13
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q8N1Q1
has only substance units: false
is encoded by: hsa:377677
is: SBO:0000252
type: Species

metaM ctp n
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
has only substance units: false
is: SBO:0000247
is: CHEBI:37563
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaM 6pgc r
type: Species
is: CHEBI:58759
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01316
name: 6-phosphonatooxy-D-gluconate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345

metaM naglc2p U c
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
is: SBO:0000247
boundary condition: false
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
has only substance units: false
is: CHEBI:18278
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false

metaR r1640
modifier: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
fast: false
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaM so3 m
type: Species
is: CHEBI:17137
initial concentration: 1.0
is: HMDB00240
constant: false
has only substance units: false
name: hydrogensulfite
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false

metaM ncam e
name: Nicotinamide
has only substance units: false
constant: false
is: C00153
initial concentration: 1.0
is: CHEBI:0
notes: FORMULA: C6H6N2O CHARGE: 0
is: SBO:0000247
boundary condition: false
is: HMDB01406
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_fc24469e_d313_4d99_9844_7b3e9d9159dd
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA532636
initial amount: NaN
name: _AA532636_1_m
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_182c3cba_40ba_4de7_b384_7b4a561e20f0
name: SLC2A8
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: Q9NY64
is encoded by: hsa:29988

http://identifiers.org/biomodels.db/MODEL1310110060#_01485570_ee98_47b8_a1a5_ceb870e969b7
is encoded by: hsa:10400
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PEMT
constant: false

metaR SCP22x
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.176
product: MODEL1310110060#
name: Sterol carrier protein 2
reversible: true
reactant: MODEL1310110060#
type: Reaction
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
modifier: MODEL1310110060#

metaM val L m
is: HMDB00883
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
name: L-valine
has only substance units: false
boundary condition: false
is: CHEBI:16414

metaR r1576
kinetic law: MODEL1310110060#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_5bbb5795_cc27_4bf3_9e62_30f3731f7c91
is: Q709F0
has only substance units: false
constant: false
is encoded by: hsa:84129
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ACAD11

metaM dadp n
name: dADP(3-)
has only substance units: false
is: HMDB01508
is: CHEBI:57667
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaR PHEMEtm
name: Heme transport to cytosol
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true

metaR GLYCTDle
product: MODEL1310110060#
name: difussion of glycerol accross the brush border membrane
is: SBO:0000185
kinetic law: MODEL1310110060#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_cd855844_668d_4aec_952e_0b1ea9534272
boundary condition: true
type: Species
is: Q16842
is: SBO:0000252
name: ST3GAL2
constant: false
is encoded by: hsa:6483
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_3837a010_8c42_42ee_8d42_5538ea9c40ca
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: FOLR1
is encoded by: hsa:2348
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_4f1304b1_72f8_42d0_a44b_d64a9cb811e9
initial amount: NaN
name: GMPPA
constant: false
is encoded by: hsa:29926
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaM cytd n
boundary condition: false
has only substance units: false
is: CHEBI:17562
is: SBO:0000247
is: HMDB00089
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
type: Species
name: cytidine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_ab010fd3_8be7_4988_b873_61ad61653c1f
is encoded by: hsa:2678
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: P19440
name: GGT1

http://identifiers.org/biomodels.db/MODEL1310110060#_eca83408_d21c_40c2_bcec_2adbe6d750d2
is: Q9NS00
name: C1GALT1
is encoded by: hsa:56913
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR ABTti
is described by: ECO:0000000
name: L-arabinitol transport via passive diffusion
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false

metaR ECOAH1m
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
reactant: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
kinetic law: MODEL1310110060#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r2526
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#

metaR TREHe
is version of: http://identifiers.org/ec-code/3.2.1.28
reactant: MODEL1310110060#
product: MODEL1310110060#
name: alpha,alpha-trehalase
modifier: MODEL1310110060#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
type: Reaction
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000269

metaR ACGAMK
kinetic law: MODEL1310110060#
reversible: false
is: SBO:0000176
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
name: N-acetylglucosamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.59
is described by: ECO:0000269
fast: false

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508
is: CHEBI:57667
name: dADP(3-)
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaR r0594
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110060#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reactant: MODEL1310110060#

metaM cmpacna c
constant: false
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57812
is: HMDB01176
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)

metaM dpcoa e
is: CHEBI:57328
constant: false
is: C00882
boundary condition: false
name: Dephospho-CoA
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: HMDB01373
initial amount: NaN
is: SBO:0000247

metaR CSNt
is: SBO:0000185
product: MODEL1310110060#
name: cytosine transport via facilated diffusion
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110060#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_24bdc001_f0ff_4679_861a_d322a910c8a7
is: P17568
has only substance units: false
is encoded by: hsa:4713
constant: false
initial concentration: NaN
boundary condition: true
name: NDUFB7
is: SBO:0000252
type: Species
initial amount: NaN

metaR VD3
reversible: true
product: MODEL1310110060#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
fast: false
is: SBO:0000176
name: Vitamin D3 formation

metaR UDPDOLPT U
product: MODEL1310110060#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
modifier: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
fast: false
reactant: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.117
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110060#

metaM hs deg1 l
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:17180
is: SBO:0000247
is: HMDB01352
type: Species
name: heparan sulfate, degradation product 1
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_cec0be8c_4528_420e_a11d_91e0a2fead92
is: P16885
name: PLCG2
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:5336
boundary condition: true
type: Species
is: SBO:0000252

metaM orn e
is: CHEBI:0
boundary condition: false
initial concentration: 1.0
is: HMDB00214
name: Ornithine
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
is: C01602
constant: false
is: SBO:0000247
type: Species

metaR NADH2 u10m
is described by: ECO:0000134
is: SBO:0000185
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: false
is version of: http://identifiers.org/ec-code/1.6.99.3
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
name: NADH dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.6.5.3
kinetic law: MODEL1310110060#
type: Reaction

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM cytd m
name: cytidine
constant: false
is: HMDB00089
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
is: CHEBI:17562
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_f5fd27d6_d43a_4313_91a8_ac8ac484a942
name: MTHFD1L
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: B2RD24
initial amount: NaN
is encoded by: hsa:25902
boundary condition: true
has only substance units: false

metaR S6TASE19ly
product: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false

metaM 56dthm c
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial concentration: 1.0
is: HMDB00079
is: SBO:0000247
name: 5,6-dihydrothymine
initial amount: NaN
has only substance units: false
is: CHEBI:27468
type: Species
boundary condition: false
constant: false

metaM fol c
boundary condition: false
is: HMDB00121
has only substance units: false
is: SBO:0000247
name: Folate
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
type: Species

metaM dha e
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
type: Species
has only substance units: false
name: glycerone
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16016
initial amount: NaN
is: HMDB01882
boundary condition: false
constant: false

metaR r1578
reversible: true
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110060#_7cc4fad7_1b40_4ad6_99f3_8026a49a66cf
is: SBO:0000252
is: E9PAY8
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: PPAP2C
is encoded by: hsa:8612

metaR DGCHOLtx
reversible: true
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110060#
is: SBO:0000185
name: bile acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110060#_89d79405_6fe1_4702_94fc_db43c1d8fc81
type: Species
is: Q92819
name: HAS2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3037
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_ea74af9c_4f1f_485e_94ff_04fef574a83a
name: ALAD
has only substance units: false
is: P13716
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:210
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_ebd391dd_6d0d_4552_a94a_b7307173a8b0
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: P36959
initial amount: NaN
type: Species
is encoded by: hsa:2766
boundary condition: true
name: GMPR

metaR PGK
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.2.3
is described by: ECO:0000134
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
name: phosphoglycerate kinase
kinetic law: MODEL1310110060#
fast: false

metaM thcholstoic x
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
boundary condition: false
is: CHEBI:18402
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_87dd103c_c8a7_428a_a826_6cdedfeae51f
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: Q9BYZ2
is encoded by: hsa:92483
has only substance units: false
initial amount: NaN
constant: false
name: LDHAL6B

metaM msa m
name: 3-oxopropanoate
is: CHEBI:33190
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB11111
initial concentration: 1.0
constant: false

metaM udpacgal g
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
is: HMDB00304
boundary condition: false
constant: false
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
is: CHEBI:57847

metaR NACHEXA13ly
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
reversible: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_4684a309_614e_4be2_814a_36d051cdef27
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:6185
is: SBO:0000252
type: Species
is: P04844
initial concentration: NaN
name: RPN2

metaM ethamp r
name: O-phosphonatoethanaminium(1-)
boundary condition: false
is: HMDB00224
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190
initial amount: NaN
is: SBO:0000247
type: Species

metaM ksi deg32 l
name: keratan sulfate I, degradation product 32
constant: false
boundary condition: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
is: HMDB00143
type: Species

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_63bcb817_c2dc_467b_bbdf_62af0f81d4fe
is: P31350
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6241
constant: false
has only substance units: false
boundary condition: true
name: RRM2

http://identifiers.org/biomodels.db/MODEL1310110060#_6af15e86_4572_40e2_963b_f0543043ad52
initial amount: NaN
boundary condition: true
is encoded by: hsa:4952
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: OCRL
is: Q01968
has only substance units: false

metaR r1579
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110060#

metaR r0517
is: SBO:0000176
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: true
reactant: MODEL1310110060#
fast: false
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110060#
type: Reaction

metaM 4nph e
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57917
initial concentration: 1.0
is: HMDB01232
name: 4-nitrophenolate
initial amount: NaN
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species

metaR HSAT1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reversible: false
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_4cb76c97_bbe8_44cf_aab5_83b6506e2e75
name: CPT1C
constant: false
type: Species
is: Q8TCG5
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:126129
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_5e3ef2c8_dde4_469d_ad34_6c1bc884c446
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:760
is: P00918
name: CA2

metaR G14T19g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110060#
reversible: false
type: Reaction
modifier: MODEL1310110060#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176

metaR ENGASE3ly
product: MODEL1310110060#
fast: false
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
name: endo-beta-N-acetylglucosaminidase, lysosomal
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_ad22ad65_392b_431b_9b91_cfed6de5f826
name: COX6A2
boundary condition: true
is: Q02221
is encoded by: hsa:1339
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR GLCt1r
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
product: MODEL1310110060#
modifier: MODEL1310110060#
name: glucose transport (uniport)
fast: false
is described by: ECO:0000269
reversible: true

metaR ATPtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110060#
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
name: ATP transporter, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110060#_6ed49910_a5c1_45d5_b25f_b6213ab06e85
is: SBO:0000252
is: P31350
name: RRM2
boundary condition: true
is encoded by: hsa:6241
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaR HISD
kinetic law: MODEL1310110060#
is described by: ECO:0000269
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.3.1.3
reversible: false
name: histidase
is: SBO:0000176
fast: false
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:

metaR RE3001M
modifier: MODEL1310110060#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.34
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3001
product: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false

metaR UGLCNACtg
is: SBO:0000185
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
name: UDP-GlcNAc Golgi transport via CMP antiport
is described by: ECO:0000269
product: MODEL1310110060#
reversible: true
type: Reaction
modifier: MODEL1310110060#

metaR ACNAMlt
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
name: N-acetylneuraminate transport into lysososme
modifier: MODEL1310110060#
fast: false
is described by: ECO:0000269
is: SBO:0000185

metaR r1427
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110060#

metaM fum c
is: C00122
is: HMDB00134
name: Fumarate
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false
is: SBO:0000247

metaM fol e
type: Species
is: SBO:0000247
name: Folate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1

metaR CYTK8
is described by: ECO:0000269
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000176
name: cytidylate kinase (CMP,dATP)

metaR RADH2
kinetic law: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110060#
name: retinal dehydrogenase (NADPH)
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_93dde479_8ea8_4c97_a4ac_8aff200e0ec9
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: HSD17B4
has only substance units: false
boundary condition: true
is: E9PB82
is encoded by: hsa:3295
type: Species
constant: false

metaR r1365
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
name: Vesicular transport
product: MODEL1310110060#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6063bad3_dde3_40a4_a66c_fc71cc066d1e
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: F8W1L5
is: SBO:0000252
is encoded by: hsa:2819
type: Species
constant: false
boundary condition: true
name: GPD1

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR PGI
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
reversible: true
kinetic law: MODEL1310110060#
name: glucose-6-phosphate isomerase
reactant: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.9
type: Reaction
product: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110060#_7dd7b18e_8752_4d8d_831c_9f787fb1f882
initial amount: NaN
is: Q9Y5P6
is encoded by: hsa:29925
initial concentration: NaN
name: GMPPB
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_e36efcb4_7681_465c_9ac5_795b55ce5a59
type: Species
name: HADHB
initial concentration: NaN
is encoded by: hsa:3032
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: P55084
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_54574be7_3bb8_46b4_a326_b4a1a54b2971
boundary condition: true
has only substance units: false
constant: false
name: DHCR7
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9UBM7
is encoded by: hsa:1717
initial concentration: NaN

metaR S6T6g
fast: false
is: SBO:0000176
kinetic law: MODEL1310110060#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110060#

metaR SIAASE3ly
type: Reaction
kinetic law: MODEL1310110060#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
name: sialidase, lysosomal
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR GNDer
is described by: ECO:0000000
product: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
type: Reaction
name: phosphogluconate dehydrogenase, endoplasmic reticulum

metaR RE3626M
modifier: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3626
reactant: MODEL1310110060#
reversible: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110060#

metaR IZPN
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110060#
reversible: false
name: Imidazolonepropionase
fast: false

metaM ksi deg25 l
name: keratan sulfate I, degradation product 25
is: SBO:0000247
boundary condition: false
is: CHEBI:57455
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
is: HMDB01354
initial amount: NaN

metaM arach c
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
boundary condition: false
constant: false
is: CHEBI:32360
is: HMDB02212
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: arachidate
initial amount: NaN

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM tdcoa x
is: C02593
type: Species
constant: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: CHEBI:57385
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521
has only substance units: false

metaR LNLNCAt
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000185
reversible: true

metaR G14T11g
is described by: ECO:0000000
modifier: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction

metaR NRPPHRSFt
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
name: norepinephrine sulfate transport (diffusion)
reversible: false
fast: false

metaM CE0713 m
initial amount: NaN
is: SBO:0000247
name: 3-oxolinoleoyl-CoA
is: HMDB02329
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:30623
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713

metaR APOC LYS BTNP
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110060#
is: SBO:0000176
name: proteolysis of apoC-Lys-btn
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
fast: false

metaR AGTim
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.6.1.44
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
is described by: ECO:0000269
reversible: false

metaM btamp m
is: SBO:0000247
constant: false
is: CHEBI:3110
type: Species
is: HMDB04220
name: Biotinyl-5'-AMP
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false
initial amount: NaN

metaR CYTK9
product: MODEL1310110060#
type: Reaction
name: cytidylate kinase (CMP,dCTP)
kinetic law: MODEL1310110060#
is described by: ECO:0000269
modifier: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110060#
fast: false
reversible: true

metaR r1364
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110060#
reversible: false
is: SBO:0000185
name: Vesicular transport
reactant: MODEL1310110060#
fast: false

metaR r1428
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false
reversible: true

metaM cmpacna g
is: SBO:0000247
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species
is: HMDB01176
boundary condition: false
initial concentration: 1.0
is: CHEBI:57812

metaM ser L m
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-serine
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
is: CHEBI:17115
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_cc38b15e_e9dd_484e_a84a_7a451ea885f1
is encoded by: hsa:3038
initial amount: NaN
type: Species
boundary condition: true
name: HAS3
is: O00219
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR PItg
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110060#
name: phosphate transport, Golgi apparatus
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_a96d9d3d_8f2e_4f13_bd22_88c18c329b1c
initial amount: NaN
name: MIA3
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: Q5JRA6
constant: false
is encoded by: hsa:375056

http://identifiers.org/biomodels.db/MODEL1310110060#_acfb7f23_6ac5_4d26_83f3_bd40fb31e0e1
is: Q8N0X4
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:171425
type: Species
name: CLYBL

metaM 4nphsf c
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: CHEBI:35422
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 4-Nitrophenyl sulfate
constant: false
boundary condition: false
has only substance units: false
is: HMDB06492
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_8d7df9f6_4966_4032_b835_32f03269bbbb
has only substance units: false
boundary condition: true
is: P15328
initial concentration: NaN
constant: false
name: FOLR1
is: SBO:0000252
is encoded by: hsa:2348
initial amount: NaN
type: Species

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_5e05b2f8_a7fa_4013_8c05_89e64303765c
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4695
name: NDUFA2
is: O43678
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_8d975251_02c8_4cfa_9062_53f47e448300
is encoded by: hsa:10905
initial concentration: NaN
initial amount: NaN
constant: false
is: O60476
is: SBO:0000252
boundary condition: true
name: MAN1A2
has only substance units: false
type: Species

metaR LINKDEG1ly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110060#
name: degradation of proteoglycan linkage region, lysosomal
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_04a80e6a_8dcb_4144_87c4_aa5ca4f8843b
type: Species
is encoded by: hsa:53354
boundary condition: true
has only substance units: false
is: Q8TE04
name: PANK1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_df32ae21_799b_4ac4_bc4d_42f58e0632df
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6487
is: Q5T4W8
name: ST3GAL3
boundary condition: true
is: SBO:0000252

metaM ksi deg17 l
boundary condition: false
is: SBO:0000247
is: HMDB00143
type: Species
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
initial amount: NaN
name: keratan sulfate I, degradation product 17

metaM hs deg12 l
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: heparan sulfate, degradation product 12
has only substance units: false
is: CHEBI:17180
is: HMDB01352
initial concentration: 1.0
constant: false
type: Species

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR RE2666C
is described by: ECO:0000000
name: RE2666
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: false
product: MODEL1310110060#
is: SBO:0000176

metaM g3m8mpdol U r
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: C05873
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM HC02175 c
is: SBO:0000247
name: caprate
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial concentration: 1.0
is: CHEBI:27689

metaM ddcacoa m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: HMDB03571
has only substance units: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species
is: CHEBI:57375
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832

metaM ditp c
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial concentration: 1.0
initial amount: NaN
is: CHEBI:61382
boundary condition: false
has only substance units: false
name: dITP(4-)
is: HMDB03537
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_6d26fbcc_5d2c_4330_a589_7a404dafee37
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AI653169_1_c
is encoded by: hsa:AI653169
boundary condition: true

metaR DOPASFt
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reversible: false
name: Dopamine 3-0-sulfate transport (diffusion)
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate

metaR r1421
reactant: MODEL1310110060#
name: Free diffusion
reversible: true
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000185
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_7463c852_9731_4341_bfbf_5d833dd1e1e0
name: _AI684467_1_m
constant: false
type: Species
is encoded by: hsa:AI684467
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_348d62ac_3807_4458_ae42_d315ae5b9527
has only substance units: false
type: Species
name: ACSS3
is: Q9H6R3
is encoded by: hsa:79611
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM glygn4 e
initial amount: NaN
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
is: HMDB00122
constant: false
notes: FORMULA: C18H31O16X CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:4167
has only substance units: false
boundary condition: false

metaR r2521
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
reversible: true
fast: false
is described by: ECO:0000000
name: Utilized transport
is: SBO:0000185
reactant: MODEL1310110060#

metaR GLCURter
type: Reaction
reactant: MODEL1310110060#
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110060#
name: glucuronate endoplasmic reticular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110060#

metaM retinal cis 9 c
is: SBO:0000247
is: HMDB01358
has only substance units: false
is: CHEBI:17898
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: all-trans-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
boundary condition: false

metaM so3 c
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:17137
type: Species
is: HMDB00240
name: Sulfite
is: SBO:0000247
is: C00094
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_65e96809_caaf_48ed_8750_6e81a438de27
initial amount: NaN
has only substance units: false
name: B3GNT2
is: Q9NY97
is: SBO:0000252
type: Species
is encoded by: hsa:10678
initial concentration: NaN
boundary condition: true
constant: false

metaR HMGCOAtx
is: SBO:0000185
is described by: ECO:0000000
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
reversible: true
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR CERT2rt
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
name: ceramide transport protein
reversible: true
reactant: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
type: Reaction
fast: false
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_156ec4db_14e8_462a_9549_5e2f2b39eae7
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: _AI539321_1_c
is encoded by: hsa:AI539321

http://identifiers.org/biomodels.db/MODEL1310110060#_6ac713c3_d52a_413c_a1c3_45d7fa1838ad
constant: false
type: Species
name: IMPDH1
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3614
is: B3KRZ3
initial concentration: NaN
is: SBO:0000252

metaM 4nphsf e
is: CHEBI:35422
is: HMDB06492
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
name: 4-Nitrophenyl sulfate

metaR r0443
reactant: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110060#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42

metaR r2520
fast: false
reactant: MODEL1310110060#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR r1649
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#

metaM core6 g
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
has only substance units: false
is: CHEBI:16478

http://identifiers.org/biomodels.db/MODEL1310110060#_08d8d522_4a8f_4a63_a473_1e0d13564f48
name: SLC5A7
is encoded by: hsa:60482
is: SBO:0000252
is: Q9GZV3
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR CITtam
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
type: Reaction
name: citrate transport, mitochondrial
reversible: true
product: MODEL1310110060#
is described by: ECO:0000269
fast: false
is: SBO:0000185
reactant: MODEL1310110060#
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_aac39f24_a198_40cd_9482_eff21e9a08a1
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _AI378339_1_m
is encoded by: hsa:AI378339

http://identifiers.org/biomodels.db/MODEL1310110060#_65061396_7893_48f9_9501_ef2bc3583e9e
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: Q8IYH3
name: HAS1
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:3036

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM HC02175 e
name: caprate
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:27689
type: Species

metaM ksi pre33 g
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 33
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: C00130
is: CHEBI:58053
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00175

metaR VITD3t2
name: Vitamin D3 uptake
is: SBO:0000185
reversible: false
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
fast: false

metaM thcholstoic m
initial concentration: 1.0
boundary condition: false
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:18402
constant: false
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

metaM nadh x
is: HMDB01487
has only substance units: false
boundary condition: false
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
constant: false
is: SBO:0000247
is: C00004
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
initial concentration: 1.0
type: Species

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR LEUt5m
name: leucine mitochondrial transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110060#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR Htg
name: proton diffusion (Golgi)
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110060#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_abdfa3a5_9f3d_4721_9888_006567b6200c
is: SBO:0000252
initial amount: NaN
name: HSD11B2
is encoded by: hsa:3291
type: Species
boundary condition: true
has only substance units: false
is: P80365
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_1d87ea0e_568e_4008_981c_d980f85a2b48
initial amount: NaN
is: Q9Y5B8
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:29922
name: NME7
boundary condition: true

metaR r1423
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reversible: false
is: SBO:0000185
type: Reaction
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#

metaR RIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110060#
fast: false
name: ribose transport via diffusion
type: Reaction

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR r1648
fast: false
is: SBO:0000185
product: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110060#_c9ad6636_4f1a_4e31_b20c_146483ed370c
type: Species
is: SBO:0000252
initial concentration: NaN
is: E7EQF2
is encoded by: hsa:54677
constant: false
has only substance units: false
initial amount: NaN
name: CROT
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_95b6d098_9a56_40cc_be3d_bc41e110f655
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: ENTPD4
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9583
is: Q9Y227

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR PNTEH
is described by: ECO:0000269
kinetic law: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.5.1.92
type: Reaction
reactant: MODEL1310110060#
name: Hydrolase Class ( RXN R02973)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_771b14c0_e94e_42c8_8c17_bc9a110d89b4
initial amount: NaN
is encoded by: hsa:1716
is: E5KSL6
initial concentration: NaN
boundary condition: true
name: DGUOK
is: SBO:0000252
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_325e31f8_b36b_4fe5_976b_9bfc57bde0f3
has only substance units: false
type: Species
name: IK
initial concentration: NaN
is: Q13123
is encoded by: hsa:3550
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaM dpcoa m
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: SBO:0000247
type: Species
has only substance units: false
name: 3'-dephospho-CoA(2-)
initial concentration: 1.0
is: HMDB01373
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57328

http://identifiers.org/biomodels.db/MODEL1310110060#_c0fa8852_dc46_4878_890a_97295707bd0f
is: SBO:0000252
type: Species
is: C9JZ62
name: TMEM91
constant: false
is encoded by: hsa:641649
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR 34DHPLACOX NADP
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110060#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
type: Reaction

metaR PALFATPtc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_5ef1758e_8b92_4719_8d62_5b3e7db7710e
initial concentration: NaN
initial amount: NaN
is: P25092
type: Species
name: GUCY2C
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2984
boundary condition: true

metaM 4nph c
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
name: 4-nitrophenolate
initial amount: NaN
is: HMDB01232
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:57917

metaM ser D e
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
type: Species
initial amount: NaN
name: D-serine
is: HMDB03406
boundary condition: false
is: CHEBI:16523
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM arachd x
initial amount: NaN
is: SBO:0000247
name: arachidonate
is: CHEBI:32395
boundary condition: false
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial concentration: 1.0
has only substance units: false
is: HMDB01043
constant: false

metaR r0879
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
reactant: MODEL1310110060#
is: SBO:0000185

metaM orn m
is: C01602
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00214
initial amount: NaN
type: Species
name: Ornithine
is: CHEBI:46912
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_7fb81186_e05c_4faf_9fb7_005c2f59381d
has only substance units: false
is: SBO:0000252
is encoded by: hsa:NOS2A
type: Species
name: _NOS2A_1_e
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r0441
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
product: MODEL1310110060#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaR UGT1A10r
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.17
reversible: true
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#

metaR r1647
fast: false
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
modifier: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_cdf4d03a_44f5_45f7_ae5b_b722f397e3e8
name: NDUFA10
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: O95299
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:4705

http://identifiers.org/biomodels.db/MODEL1310110060#_1d09d551_23fe_4f82_bac0_1ef313a47622
is encoded by: hsa:2821
constant: false
is: P06744
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: GPI
has only substance units: false
boundary condition: true
type: Species

metaR r1381
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: true
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_594c121d_ba6f_4911_b921_836ce88ae8ed
initial concentration: NaN
is: O75610
type: Species
constant: false
is encoded by: hsa:10637
is: SBO:0000252
name: LEFTY1
initial amount: NaN
boundary condition: true
has only substance units: false

metaR AG13T17g
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110060#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR GLYSNAT5tc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR RE3421R
reactant: MODEL1310110060#
reversible: true
product: MODEL1310110060#
name: RE3421
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
fast: false
is: SBO:0000176

metaR r1090
fast: false
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction

metaM CE4790 m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
has only substance units: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
type: Species
is: SBO:0000247
is: CHEBI:12947

metaM glyc3p x
name: Glycerol 3-phosphate
is: SBO:0000247
is: C00093
is: HMDB00126
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6269eb32_e9c5_40b5_b488_8e12ed9f1f3f
is: SBO:0000252
has only substance units: false
type: Species
name: MOGS
boundary condition: true
initial amount: NaN
is: F5H6D0
constant: false
initial concentration: NaN
is encoded by: hsa:7841

metaR r1843
reversible: false
fast: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110060#
name: Y+LAT2 Utilized transport

metaR r1646
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
is: SBO:0000185
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2310
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR GDPtg
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
name: GDP intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
type: Reaction
fast: false
product: MODEL1310110060#
is: SBO:0000185

metaM nadh r
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
initial amount: NaN
initial concentration: 1.0
name: NADH(2-)
has only substance units: false
is: SBO:0000247
is: CHEBI:57945
is: HMDB01487
boundary condition: false
constant: false
type: Species

metaR NACHEX13ly
product: MODEL1310110060#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
kinetic law: MODEL1310110060#
type: Reaction

metaR r2525
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110060#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false

metaR ARACHCRNt
reversible: false
reactant: MODEL1310110060#
name: transport into the mitochondria (carnitine)
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110060#

metaR 34HPPOR
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
type: Reaction
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.13.11.27
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110060#_a0c4ca2d_e0f3_49be_ab6d_d316bb962098
is: Q9NS82
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC7A10
boundary condition: true
type: Species
constant: false
is encoded by: hsa:56301
initial concentration: NaN

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_b0f50f55_2955_4e07_b6cf_91a33051b007
type: Species
is: Q99714
is encoded by: hsa:3028
constant: false
boundary condition: true
name: HSD17B10
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r1380
product: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction

metaM fe2 m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00692
has only substance units: false
constant: false
type: Species
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
boundary condition: false
is: CHEBI:29033
name: Fe2+

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaM dhcholestanate c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
has only substance units: false
boundary condition: false
is: HMDB00359
type: Species
initial concentration: 1.0

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR r2089
type: Reaction
reversible: true
modifier: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
product: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR 5OXPROt
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110060#
is described by: ECO:0000134
name: Transport of 5-oxoprolinate
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_b57d49c9_14c6_4d2f_8b9b_3fef4ac0b8e3
boundary condition: true
constant: false
name: NDUFA3
is encoded by: hsa:4696
initial concentration: NaN
type: Species
is: O95167
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM ksi pre21 g
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00175
constant: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
name: keratan sulfate I biosynthesis, precursor 21
has only substance units: false
type: Species
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110060#_8ab8a859_9454_40b0_87e5_f85094ce1505
boundary condition: true
is encoded by: hsa:113026
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: Q8N3E9
name: PLCD3
is: SBO:0000252

metaM m8mpdol U r
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
initial concentration: 1.0
constant: false
is: CHEBI:59093
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM core6 l
initial concentration: 1.0
constant: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species
boundary condition: false
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
initial amount: NaN
name: Core 6
has only substance units: false

metaR CRNrtx
is: SBO:0000185
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
name: reversible transport of L-Carnitine in peroxisome
reactant: MODEL1310110060#
type: Reaction
fast: false
kinetic law: MODEL1310110060#
reversible: true
is described by: ECO:0000134

metaR r1645
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_bd266c74_2249_42b6_bbaf_825d24dbfb6a
name: SLC2A13
is encoded by: hsa:114134
is: Q96QE2
type: Species
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM xol27oh r
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
name: 26-hydroxycholesterol
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:17703
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_691688e3_8a9e_4011_8140_9ffdad386484
name: PRDX1
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:5052
is: Q06830
initial amount: NaN
initial concentration: NaN

metaR r2311
kinetic law: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
fast: false
product: MODEL1310110060#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reactant: MODEL1310110060#

metaM ser D c
boundary condition: false
constant: false
name: D-serine
is: HMDB03406
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:16523
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

metaM arachd r
is: HMDB01043
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: arachidonate

metaR AG13T6g
modifier: MODEL1310110060#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110060#

metaR GLYCtm
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
name: glycerol transport
kinetic law: MODEL1310110060#

metaM pail45p hs c
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0

metaM ksi pre27 g
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00130
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 27
has only substance units: false

metaR PItn
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
type: Reaction
name: phosphate transport, nuclear
fast: false
is described by: ECO:0000000
product: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_a1bce643_2373_48bb_b14f_15509d7b8ff5
initial amount: NaN
is: O15056
is: SBO:0000252
is encoded by: hsa:8871
initial concentration: NaN
name: SYNJ2
type: Species
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_2e7cf974_d3b2_411f_be3a_94f80354ee7d
boundary condition: true
type: Species
is: Q08828
constant: false
is encoded by: hsa:107
initial concentration: NaN
is: SBO:0000252
name: ADCY1
has only substance units: false
initial amount: NaN

metaM ksi deg33 l
is: CHEBI:12936
constant: false
is: HMDB00143
type: Species
has only substance units: false
name: keratan sulfate I, degradation product 33
is: SBO:0000247
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR O2Stn
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
reversible: true
name: superoxide anion transport via diffusion (nucleus)

metaM fmn c
name: FMN
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01520
is: CHEBI:58210
is: SBO:0000247
is: C00061
type: Species

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaR PGLer
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
is described by: ECO:0000269
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
name: 6-phosphogluconolactonase, endoplasmic reticulum
product: MODEL1310110060#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.47

metaM ksi deg19 l
initial concentration: 1.0
name: keratan sulfate I, degradation product 19
has only substance units: false
is: CHEBI:57455
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01354
constant: false

metaR r1644
reversible: true
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_6f028852_a3bc_4d09_a7b6_fa775b0684bf
constant: false
initial concentration: NaN
is encoded by: hsa:55967
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: NDUFA12
is: F8VQS7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_dcfeac03_2020_418f_8bba_f96013bdb35c
is: SBO:0000252
is: Q9Y6K8
constant: false
is encoded by: hsa:26289
has only substance units: false
boundary condition: true
name: AK5
initial amount: NaN
initial concentration: NaN
type: Species

metaM HC01842 c
constant: false
is: CHEBI:31997
is: SBO:0000247
type: Species
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Phosphodimethylethanolamine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_c6f208f4_98de_4217_b190_9d7824429631
is encoded by: hsa:22305
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: _22305_2_c
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_c2a59e65_e971_4eae_84a8_dea7401788c7
is encoded by: hsa:3712
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: IVD
is: B3KVI7

metaM prostgd2 c
type: Species
initial amount: NaN
is: CHEBI:57406
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01403
name: prostaglandin D2(1-)

http://identifiers.org/biomodels.db/MODEL1310110060#_acc34b2c_d541_4a16_8598_79e256212f28
initial amount: NaN
is: Q86WU2
is encoded by: hsa:197257
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: LDHD

metaM pe hs m
constant: false
type: Species
initial amount: NaN
name: phosphatidylethanolamine
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial concentration: 1.0
is: CHEBI:16038

http://identifiers.org/biomodels.db/MODEL1310110060#_056c5dbe_813f_441c_9ca7_9cd795a8fe05
is: Q13057
has only substance units: false
boundary condition: true
is encoded by: hsa:80347
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: COASY
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_f6cf43be_6e89_488c_98ce_a84e98fb3ba2
initial amount: NaN
type: Species
name: ACADM
is: P11310
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:34
has only substance units: false
constant: false

metaM mpdol U c
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
constant: false
is: CHEBI:18396
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
initial amount: NaN

metaR O2Stm
reversible: true
kinetic law: MODEL1310110060#
name: superoxide anion transport via diffusion (mitochondria)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction
fast: false
product: MODEL1310110060#

metaR CYTK6n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
name: cytidylate kinase (CMP,CTP),nuclear
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110060#

metaR r1842
product: MODEL1310110060#
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
reversible: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC01610 e
has only substance units: false
is: CHEBI:28607
name: CoproporphyrinogenI
constant: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR r1643
reversible: true
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_7f513669_6877_4187_95d8_39ec61f0ab94
initial amount: NaN
boundary condition: true
name: SLC2A3
is encoded by: hsa:6515
is: P11169
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaR LACZe
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.108
name: b-galactosidase, extracellular
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
modifier: MODEL1310110060#

metaM i c
name: iodide
boundary condition: false
type: Species
is: CHEBI:16382
constant: false
is: HMDB12238
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_3c1eb7da_4f55_467f_82f1_11fc8b4b6601
is: SBO:0000252
constant: false
name: PDE8A
initial amount: NaN
type: Species
is encoded by: hsa:5151
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_1b8ee9a1_86cd_4527_9284_5d2a1004746d
is encoded by: hsa:5321
is: SBO:0000252
initial concentration: NaN
name: PLA2G4A
constant: false
has only substance units: false
is: P47712
type: Species
initial amount: NaN
boundary condition: true

metaR r2315
product: MODEL1310110060#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110060#
is: SBO:0000185

metaR r2097
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110060#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110060#

metaM glx c
initial amount: NaN
is: HMDB00119
name: glyoxylate
initial concentration: 1.0
is: CHEBI:36655
is: SBO:0000247
constant: false
has only substance units: false
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false

metaM HC01104 e
name: 4-nitrophenyl phosphate(2-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
has only substance units: false
constant: false
is: CHEBI:61146
initial concentration: 1.0
boundary condition: false
type: Species

metaR PNTK
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.33
name: pantothenate kinase
product: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
reversible: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176

metaR CYTK7n
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110060#
name: cytidylate kinase (CMP,UTP),nuclear
product: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction

metaR THYOXt2
fast: false
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
reactant: MODEL1310110060#
name: T4 transport via facilitated diffusion
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_34c0480a_192a_4e9c_bbea_93583a6ff383
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GLDC
boundary condition: true
constant: false
is encoded by: hsa:2731
is: P23378
type: Species

metaR ACACtx
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110060#
fast: false
name: acetoacetate intracellular transport unknown mechanism

http://identifiers.org/biomodels.db/MODEL1310110060#_74f35f57_4472_495b_83c9_1f79dc93eefe
type: Species
initial amount: NaN
boundary condition: true
is: Q15392
is: SBO:0000252
is encoded by: hsa:1718
has only substance units: false
initial concentration: NaN
name: DHCR24
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6404d93b_3fb5_4929_a4a5_9d43d88aa0c5
is encoded by: hsa:2954
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GSTZ1
is: A6NED0

http://identifiers.org/biomodels.db/MODEL1310110060#_41b32a7f_9f29_4e86_b6fe_f14c49e8d8c3
name: SDS
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:10993
has only substance units: false
is: P20132

metaR RE2677E
name: RE2677
kinetic law: MODEL1310110060#
reversible: false
type: Reaction
fast: false
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
reactant: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_0b504bc2_b837_4b60_aefe_7a0d0a96004d
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55967
initial amount: NaN
has only substance units: false
name: NDUFA12
type: Species
initial concentration: NaN
constant: false
is: F8VQS7

metaM xol27oh m
has only substance units: false
initial concentration: 1.0
is: HMDB02103
is: CHEBI:17703
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 26-hydroxycholesterol

metaR RE1526M
name: RE1526
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR 3HBCOAHLm
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
product: MODEL1310110060#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR NRPPHRt4 2 r
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
product: MODEL1310110060#
name: Norepinephrine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110060#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR RETNt
type: Reaction
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110060#
fast: false
name: retinoic acid transport

metaM lthstrl r
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01170
is: SBO:0000247
is: CHEBI:17168
name: 5alpha-cholest-7-en-3beta-ol
boundary condition: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189

metaM 6pgl r
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01127
initial concentration: 1.0
is: CHEBI:57955
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
boundary condition: false
initial amount: NaN

metaM ump e
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: UMP(2-)
boundary condition: false
is: HMDB00288
is: CHEBI:57865
initial amount: NaN

metaR r2014
reversible: false
product: MODEL1310110060#
modifier: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_c78715f2_46c5_497c_ad1c_7000c861a9f7
is encoded by: hsa:54187
is: Q9NR45
name: NANS
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaM Tn antigen g
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false
has only substance units: false
boundary condition: false
is: C04383
initial concentration: 1.0
type: Species
name: Tn antigen
is: SBO:0000247
initial amount: NaN

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_644c4707_aa8b_44c4_b391_d2eb8d085539
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: ST6GAL1
is encoded by: hsa:6480

http://identifiers.org/biomodels.db/MODEL1310110060#_27485d00_826a_4eb9_aba0_36de52162939
is: O95479
constant: false
initial concentration: NaN
is: SBO:0000252
name: H6PD
type: Species
has only substance units: false
is encoded by: hsa:9563
initial amount: NaN
boundary condition: true

metaR NDPK8n
reactant: MODEL1310110060#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
fast: false
product: MODEL1310110060#
type: Reaction

metaR GLCt4
is: SBO:0000185
fast: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
product: MODEL1310110060#
name: glucose transport via sodium symport
type: Reaction
reversible: true
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_55e46f84_33ed_4a30_a489_5fb500d059b8
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q86YU0
type: Species
is encoded by: hsa:766
name: CA7
initial concentration: NaN
constant: false

metaM tyr L c
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00158
is: CHEBI:17895
is: SBO:0000247
name: L-tyrosine

http://identifiers.org/biomodels.db/MODEL1310110060#_445eda75_e2fd_4284_8717_42e0d364b618
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR r2314
type: Reaction
reactant: MODEL1310110060#
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0944
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
name: Active transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_4bba485f_0444_4760_b4d4_f94e1695418d
initial amount: NaN
type: Species
is: Q13630
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:7264
name: TSTA3
has only substance units: false
is: SBO:0000252

metaR GGH 7THFe
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
fast: false
name: Gamma-glutamyl hydrolase (7THF), extracellular
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_39c31cb7_5acb_4fb6_a76f_92385c08d881
initial concentration: NaN
is encoded by: hsa:7389
is: SBO:0000252
name: UROD
boundary condition: true
type: Species
is: P06132
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_a4c7e2cb_4354_400e_83fb_0694328a45fd
is: Q5MY95
type: Species
is: SBO:0000252
is encoded by: hsa:377841
boundary condition: true
has only substance units: false
constant: false
name: ENTPD8
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_6380f9a6_aaf9_4133_b954_c9b579d310f1
initial concentration: NaN
is: SBO:0000252
is: P22304
has only substance units: false
boundary condition: true
initial amount: NaN
name: IDS
constant: false
is encoded by: hsa:3423
type: Species

metaR PItx
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
type: Reaction
fast: false
is described by: ECO:0000000
name: Phosphate transporter, peroxisome
product: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110060#_7fa7b5a3_c3b9_443e_b7ee_f883a853751d
boundary condition: true
is: P22413
constant: false
initial amount: NaN
name: ENPP1
is encoded by: hsa:5167
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r2129
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_6f0bb8af_ef44_4052_b5dc_e84f13c6b596
has only substance units: false
initial amount: NaN
is: A8K9Q8
boundary condition: true
constant: false
name: B3GNT6
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:192134

metaR r2098
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaR NNATr
product: MODEL1310110060#
name: nicotinate-nucleotide adenylyltransferase
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (349565.1) or (23057.2) or (23057.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:12574164,PMID:14516279 NOTES:JLR
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.7.1
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_b7cb8db9_7dd1_4ff2_971e_fb85642d946b
initial concentration: NaN
is encoded by: hsa:4540
constant: false
has only substance units: false
is: P03915
name: ND5
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_fc6f061e_5f94_4b79_a8ca_63a7e931bad8
name: SLC25A21
initial concentration: NaN
is: G3V4L5
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:89874

metaM tdcoa m
initial amount: NaN
is: SBO:0000247
is: C02593
boundary condition: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
has only substance units: false

metaR DNDPt34m
reactant: MODEL1310110060#
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
name: dGDP transport via dTDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269

metaR TKT1
name: transketolase
is: SBO:0000176
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.1
reactant: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction

metaM i e
initial concentration: 1.0
is: CHEBI:16382
constant: false
type: Species
boundary condition: false
is: HMDB12238
is: SBO:0000247
name: iodide
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false

metaM nrpphr e
is: CHEBI:33569
initial amount: NaN
name: Norepinephrine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
is: HMDB00216
initial concentration: 1.0
type: Species
constant: false

metaR RE1709C
reversible: true
name: RE1709
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110060#

metaR NDPK10
modifier: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
fast: false
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:dIDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110060#
type: Reaction

metaR GGH 6THFe
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
name: Gamma-glutamyl hydrolase (6THF), extracellular
fast: false
is: SBO:0000176

metaR OCCOAtx
name: fatty acid intracellular transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
product: MODEL1310110060#

metaR r2313
kinetic law: MODEL1310110060#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110060#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#

metaR RE2677G
type: Reaction
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
name: RE2677
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_6317e21c_4dc3_4987_8785_5595024d0fb0
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:111
initial concentration: NaN
has only substance units: false
name: ADCY5
boundary condition: true
type: Species
is: O95622

http://identifiers.org/biomodels.db/MODEL1310110060#_b8bfff05_42a6_40ea_8395_b4c8a6f727a9
is encoded by: hsa:2998
is: SBO:0000297
initial amount: NaN
has part: O15488
type: Species
constant: false
name: GYS2:GYG2
has only substance units: false
has part: P54840
is encoded by: hsa:8908
boundary condition: true
initial concentration: NaN

metaM ump c
initial amount: NaN
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
is: C00105
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00288
is: CHEBI:57865

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR r2126
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110060#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaM 10fthf7glu e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C50H57N13O25 CHARGE: -8
name: 10-formyltetrahydrofolate-[Glu](7)
is: CHEBI:57454
has only substance units: false
boundary condition: false
constant: false
is: HMDB00972
type: Species
initial concentration: 1.0

metaR HSD11B1r
fast: false
reversible: true
reactant: MODEL1310110060#
name: 11-beta-hydroxysteroid dehydrogenase type 1
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
kinetic law: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.146

metaR r2099
type: Reaction
reversible: true
modifier: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#

metaM ksi pre11 g
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:28067
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 11

metaM ethamp c
boundary condition: false
constant: false
is: HMDB00224
has only substance units: false
name: ethamp[c]
type: Species
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR TKT2
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.1
name: transketolase
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
product: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_8221f45e_f3ff_4d6c_82b6_d9d5e08369f6
boundary condition: true
initial amount: NaN
name: _BG035985_1_c
initial concentration: NaN
is encoded by: hsa:BG035985
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaM cortsn r
is: HMDB02802
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
name: cortisone
is: CHEBI:16962
initial amount: NaN
constant: false

metaR PIPLC
product: MODEL1310110060#
is described by: ECO:0000000
name: phosphatidylinositol phospholipase C
modifier: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
kinetic law: MODEL1310110060#
type: Reaction

metaR r0660
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110060#
reversible: true
is: SBO:0000176
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
kinetic law: MODEL1310110060#

metaR r0942
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR RTOTAL2FATPc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaM 5thf e
initial concentration: 1.0
boundary condition: false
name: pentaglutamyl folate (THF)
type: Species
is: HMDB06487
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_970d69ca_2f49_471b_b7db_363cd5e9402e
name: PRDX2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:7001
has only substance units: false

metaR r2312
reversible: true
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f96acec9_214f_4926_a961_8b2b2a587197
type: Species
name: _642502_1_c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:642502
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR DM dsT antigen g
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaR C12OHc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaM CE2417 m
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
has only substance units: false
constant: false
is: HMDB11123
is: CHEBI:28387
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

metaR r2015
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110060#

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_05e20b73_3d9c_42ee_b229_3653972ef9ff
initial concentration: NaN
is encoded by: hsa:58510
name: PRODH2
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9UF12
constant: false

metaR AG13T16g
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
modifier: MODEL1310110060#
product: MODEL1310110060#

metaR r2127
fast: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110060#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#

metaM apoC Lys c
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:32551
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H13N2OX CHARGE: 0
name: Apocarboxylase (Lys residue)
is: HMDB00182

metaR MECOALm
is described by: ECO:0000212
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.5
kinetic law: MODEL1310110060#
is: SBO:0000176
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

metaR HS3ly
fast: false
product: MODEL1310110060#
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false
reactant: MODEL1310110060#

metaR r0941
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
type: Reaction
product: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
name: Free diffusion
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_4675e66a_e9d8_4051_810f_a70bc4bedd7c
is encoded by: hsa:8310
constant: false
boundary condition: true
name: ACOX3
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: O15254

metaR r0885
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
reversible: true
reactant: MODEL1310110060#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM nrpphr c
type: Species
boundary condition: false
is: CHEBI:33569
constant: false
is: SBO:0000247
initial amount: NaN
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
initial concentration: 1.0
is: HMDB00216

metaR r2093
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110060#
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_587b9944_582f_44eb_924c_0b390a8f4411
initial concentration: NaN
initial amount: NaN
name: PPA2
type: Species
boundary condition: true
is: Q9H2U2
is: SBO:0000252
is encoded by: hsa:27068
constant: false
has only substance units: false

metaR r2319
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r1008
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_00e249b6_abd5_4ef5_97bc_f0db7a19d893
is: P17050
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: NAGA
is encoded by: hsa:4668
initial concentration: NaN

metaM ksi deg1 l
constant: false
is: SBO:0000247
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: HMDB00174
initial amount: NaN
name: keratan sulfate I, degradation product 1
initial concentration: 1.0
type: Species
is: CHEBI:18287
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_d8b328be_a233_4823_bc7a_a11b64f358c0
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI990637
type: Species
initial concentration: NaN
name: _AI990637_1_x
initial amount: NaN
boundary condition: true
constant: false

metaR r2124
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
product: MODEL1310110060#
modifier: MODEL1310110060#

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaR PROSTGE1t
reactant: MODEL1310110060#
fast: false
reversible: true
modifier: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_425e785c_4301_45f3_bc6c_e344421fc634
is: P26439
name: HSD3B2
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:3284
boundary condition: true

metaR ACOAO7p
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: false
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110060#
fast: false
modifier: MODEL1310110060#

metaR r0940
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Free diffusion
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_9295f6a0_7d43_4ebb_aa3e_edf087034624
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O14734
initial amount: NaN
constant: false
name: ACOT8
is: SBO:0000252
is encoded by: hsa:10005

metaM pail45p hs n
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: CHEBI:28910
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaR HACD1m
is: SBO:0000176
fast: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
type: Reaction
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
reactant: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_14f0cfa2_0bf9_4d35_8bbf_4b0f46fa4150
initial amount: NaN
name: AKR1C4
is encoded by: hsa:1109
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: P17516
is: SBO:0000252
type: Species

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_0c22373c_7ff6_47c7_81b3_e464d35963a5
name: ADH1A
boundary condition: true
initial concentration: NaN
constant: false
is: P07327
has only substance units: false
is encoded by: hsa:124
initial amount: NaN
is: SBO:0000252
type: Species

metaR r2318
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true

metaR r1007
is: SBO:0000185
fast: false
kinetic law: MODEL1310110060#
reversible: true
name: Facilitated diffusion
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110060#
is described by: ECO:0000000

metaR r2094
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000000
fast: false

metaM HC02216 c
is: CHEBI:28922
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
initial amount: NaN
name: prostaglandin-f2beta
constant: false
is: SBO:0000247

metaR r2125
fast: false
modifier: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
is: SBO:0000185

metaR Htr
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
name: H transporter, endoplasmic reticulum
type: Reaction
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_bf760db4_8113_43f7_ad98_20d71d69f1dd
name: INPP5J
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:27124
initial concentration: NaN
type: Species

metaM leu L c
name: L-leucine
has only substance units: false
is: HMDB00687
is: CHEBI:15603
constant: false
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaM pail45p hs m
constant: false
is: CHEBI:28910
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN

metaM Tn antigen l
name: Tn antigen
type: Species
is: C04383
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reversible: false

metaR r2398
is described by: ECO:0000000
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110060#
reversible: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110060#

metaR r1639
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110060#

metaR ASCBt4
fast: false
reversible: true
kinetic law: MODEL1310110060#
name: L-ascorbate transport via proton symport
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
product: MODEL1310110060#

metaR DIDPtn
name: dIDP nuclear transport
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true
type: Reaction

metaR UGCG
is version of: http://identifiers.org/ec-code/2.4.1.80
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: false
type: Reaction
name: Ceramide glucosyltransferase
modifier: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176

metaM gdp n
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58189
is: HMDB01201
initial concentration: 1.0
name: GDP(3-)

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_f388f20c_c644_4abe_bedb_e51cf50fd314
has only substance units: false
is: Q9UGH3
boundary condition: true
initial amount: NaN
name: SLC23A2
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:9962
type: Species

metaR r2095
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM ctp c
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
name: CTP
is: HMDB00082
initial amount: NaN
is: CHEBI:37563
type: Species
is: SBO:0000247
boundary condition: false
is: C00063
constant: false
initial concentration: 1.0

metaR r2317
fast: false
reversible: true
type: Reaction
product: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110060#

metaM C05280 m
name: cis,cis-3,6-Dodecadienoyl-CoA
constant: false
has only substance units: false
is: HMDB03952
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
type: Species
is: CHEBI:28002
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_c1a7e668_c29c_4eb1_b66e_426adb81371e
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1890
is: P19971
type: Species
name: TYMP
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaR r2122
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
product: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_69396886_67fd_4197_a50b_fb8bdc2c4b87
initial concentration: NaN
constant: false
is encoded by: hsa:4846
initial amount: NaN
is: A0S0A7
name: NOS3
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_7486ce25_1582_4e30_ac1a_154581d53f9e
initial concentration: NaN
name: _AI620219_1_e
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:AI620219
has only substance units: false
is: SBO:0000252

metaM ksi pre17 g
constant: false
is: CHEBI:28067
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
name: keratan sulfate I biosynthesis, precursor 17
is: SBO:0000247
type: Species

metaR LNLCCPT1
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176
product: MODEL1310110060#
fast: false
name: carnitine O-palmitoyltransferase

metaM hs deg16 l
is: HMDB02704
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: CHEBI:21338
name: heparan sulfate, degradation product 16

metaR r0321
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is: SBO:0000176
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.3.5.2
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110060#

metaR UMPK6n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: UMP kinase (dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110060#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_93038955_b5ff_4393_831e_547166d95a33
boundary condition: true
is: SBO:0000252
constant: false
name: ENTPD3
is encoded by: hsa:956
initial concentration: NaN
type: Species
is: O75355
initial amount: NaN
has only substance units: false

metaR r1088
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
type: Reaction
product: MODEL1310110060#
name: Active transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false

metaR P450SCC1m
type: Reaction
name: cholesterol monooxygenase
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000134
product: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

metaM tyr L e
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
initial concentration: 1.0
is: HMDB00158
type: Species
constant: false
name: L-tyrosine
is: CHEBI:17895
has only substance units: false

metaM ksi pre19 g
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00175
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 19
is: C00130
is: CHEBI:58053
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
has only substance units: false

metaM aacoa x
initial concentration: 1.0
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57286
initial amount: NaN
constant: false
type: Species
name: acetoacetyl-CoA(4-)
is: HMDB01484

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR r2399
reversible: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_b042dd47_21ac_4531_8e38_d080c0eb61ad
constant: false
is encoded by: hsa:F23536
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: _F23536_1_m
type: Species

metaM gdp m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58189
type: Species
is: HMDB01201
is: C00035
has only substance units: false
name: GDP
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR r2316
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110060#

metaR r2096
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM HC02216 e
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
is: CHEBI:28922
boundary condition: false
name: prostaglandin-f2beta
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_ad927a76_082c_49e5_a7c3_25a0344836e0
initial concentration: NaN
constant: false
name: PDE1A
is encoded by: hsa:5136
boundary condition: true
is: Q9Y633
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_44a5850a_f417_41aa_a0cd_bddced52e82b
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: SLC13A4
is: Q9UKG4
is encoded by: hsa:26266
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_211d82e2_1fb6_4847_9985_cc03f0aca1cd
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: P48735
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3418
boundary condition: true
name: IDH2

metaR r2123
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_6be14460_5444_4de3_96d7_adcbf679e891
has only substance units: false
initial concentration: NaN
name: AFMID
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: Q63HM1
is encoded by: hsa:125061
initial amount: NaN

metaR DGCHOLte
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110060#
name: bile acid intracellular transport
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
fast: false

metaR NADtx
kinetic law: MODEL1310110060#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000134
name: transport of NAD into peroxisome
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_bee56c4d_f864_41f1_b859_af91958bcf32
name: NDUFB3
initial amount: NaN
boundary condition: true
constant: false
is: Q6IB80
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4709
type: Species

metaM leu L e
name: L-leucine
is: CHEBI:15603
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
boundary condition: false

metaR DOLDPP Uer
is: SBO:0000176
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.6.1.43
reversible: false
fast: false
is described by: ECO:0000000

metaM arachd e
type: Species
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: arachidonate
is: CHEBI:32395
is: SBO:0000247
has only substance units: false

metaM rib D e
type: Species
initial amount: NaN
is: CHEBI:16988
constant: false
is: SBO:0000247
is: HMDB00283
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: D-ribose
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119

metaM maltttr e
is: SBO:0000247
initial amount: NaN
is: C02052
has only substance units: false
is: http://identifiers.org/pubchem.compound/5141
boundary condition: false
type: Species
name: Maltotetraose
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: HMDB01296
initial concentration: 1.0
constant: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM udpacgal l
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00304
initial concentration: 1.0
boundary condition: false

metaR r2120
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110060#
is: SBO:0000185
fast: false
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX digalsgalside hs LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Digalactosylceramidesulfate exchange
type: Reaction

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM hom L e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719
name: L-homoserine
type: Species
is: CHEBI:15699

metaR r0669
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
fast: false
product: MODEL1310110060#
reversible: false

metaM sucr e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: SBO:0000247
is: HMDB00258
boundary condition: false
is: CHEBI:17992
initial concentration: 1.0
is: C00089
type: Species
initial amount: NaN
name: Sucrose
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_19509524_586e_40de_9fa7_e9cbde4802d6
initial concentration: NaN
type: Species
is encoded by: hsa:U37519
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: _U37519_1_c

http://identifiers.org/biomodels.db/MODEL1310110060#_50ec0653_51e5_49c1_a53e_ba1fa7206ab8
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
boundary condition: true
constant: false
name: PDE9A
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_7c519ee1_af04_4743_8b38_d8c1a86565e3
initial concentration: NaN
type: Species
has only substance units: false
name: SLC7A5
boundary condition: true
constant: false
is: Q8IV97
is: SBO:0000252
is encoded by: hsa:8140
initial amount: NaN

metaR TMDPP
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000269
reversible: true
name: thymidine phosphorylase
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.2.4
fast: false

metaM dd2coa m
is: SBO:0000247
has only substance units: false
type: Species
constant: false
name: trans-dodec-2-enoyl-CoA(4-)
is: HMDB03712
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
boundary condition: false
is: CHEBI:57330
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_f0f5c463_ac55_4686_baa9_93cfa6e290eb
constant: false
is encoded by: hsa:7167
boundary condition: true
name: TPI1
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: Q53HE2

metaM CE2421 m
initial amount: NaN
is: SBO:0000247
is: HMDB02329
name: (3S)-3-hydroxylinoleoyl-CoA
initial concentration: 1.0
has only substance units: false
is: CHEBI:30623
boundary condition: false
type: Species
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
constant: false

metaR URAt
fast: false
name: uracil transport via facilated diffusion
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: true
is: SBO:0000185

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM HC02207 c
initial amount: NaN
name: prostaglandin-c2
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: CHEBI:27555
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_3a4cded4_434e_42be_bd24_5a6df875ba7d
initial amount: NaN
is encoded by: hsa:2720
is encoded by: hsa:2588
has only substance units: false
boundary condition: true
constant: false
has part: Q99519
type: Species
name: GALNS:GLB1:NEU1:CTSA
has part: P34059
initial concentration: NaN
is: SBO:0000297
has part: P10619
is encoded by: hsa:5476
is encoded by: hsa:4758
has part: P16278

metaM pro D e
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: CHEBI:16313
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: D-proline
is: HMDB03411
has only substance units: false

metaM val L c
type: Species
is: SBO:0000247
is: HMDB00883
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:16414
initial amount: NaN
boundary condition: false

metaR CYTDtm
reversible: true
type: Reaction
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
name: cytidine facilated transport in mitochondria
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
modifier: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#

metaR LNLCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaR ECOAH12m
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110060#
is: SBO:0000176

metaM ctp e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
name: CTP(4-)
boundary condition: false
type: Species
is: CHEBI:37563
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_df25015e_7028_42f6_b6d5_5882cc597702
is encoded by: hsa:159963
boundary condition: true
initial concentration: NaN
is: Q1EHB4
type: Species
is: SBO:0000252
constant: false
name: SLC5A12
has only substance units: false
initial amount: NaN

metaM creat c
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
initial amount: NaN
name: creatine
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00064
is: CHEBI:16919

http://identifiers.org/biomodels.db/MODEL1310110060#_874d595f_8f5e_40ca_9f40_cb1ad5d7b88b
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI915649
initial amount: NaN
name: _AI915649_1_c
constant: false
boundary condition: true

metaM aacoa m
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
name: acetoacetyl-CoA(4-)
is: HMDB01484

metaR r2121
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_40b0673d_cf1d_4f8c_9c2a_87e81c7455b4
name: ENTPD3
initial amount: NaN
initial concentration: NaN
is: O75355
type: Species
boundary condition: true
is encoded by: hsa:956
is: SBO:0000252
constant: false
has only substance units: false

metaR RE1709N
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
is: SBO:0000176
fast: false
reactant: MODEL1310110060#
name: RE1709
modifier: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_2b6e1b55_b751_452f_8596_0f5e633190fc
type: Species
constant: false
name: EARS2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:124454
initial amount: NaN
boundary condition: true
is: Q5JPH6
initial concentration: NaN

metaR r2090
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_e40a025a_ba18_4434_814a_6a064b44b8fc
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: GUCY2F
is encoded by: hsa:2986
is: P51841
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_e0257a9f_de31_4dfe_8157_c087c0fb0103
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: PANK2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:80025

metaR S6T14g
is described by: ECO:0000000
kinetic law: MODEL1310110060#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_4906604b_5fad_4c03_93ba_28ad9596dff5
is: SBO:0000252
has only substance units: false
type: Species
is: Q4KWH8
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:23007
name: PLCH1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_0f6e83ef_bbaa_4b99_a023_4794132ee367
boundary condition: true
name: ALDH3A2
is: P51648
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:224
type: Species

metaR r1156
is described by: ECO:0000000
type: Reaction
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is: SBO:0000176
fast: false
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM ksii core4 pre4 g
boundary condition: false
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58053
notes: FORMULA: C61H99N5O43X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 4
is: C00130
type: Species
is: SBO:0000247

metaM rib D c
type: Species
initial amount: NaN
is: CHEBI:16988
has only substance units: false
is: HMDB00283
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: D-ribose
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119

metaR CYTDtn
name: cytidine transport in nucleus
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR M8MASNterg
name: m8masn transport from ER to Golgi apparatus
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD

metaM octa e
type: Species
constant: false
is: C06423
is: SBO:0000247
is: HMDB00482
boundary condition: false
has only substance units: false
notes: FORMULA: C8H15O2 CHARGE: -1
name: octanoate (n-C8:0)
is: CHEBI:25646
initial amount: NaN
initial concentration: 1.0

metaM lpam m
is: HMDB00962
name: lipoamide
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17460

metaM hom L c
is: CHEBI:15699
name: L-homoserine
is: HMDB00719
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR GLYBt4 2 r
type: Reaction
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
name: Betaine transport (sodium symport) (2:1)
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_5785090d_ff19_40f7_9e62_db1aece18725
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ACAT2
is encoded by: hsa:39
is: Q9BWD1
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaM nrpphrsf e
is: HMDB02062
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/123747
type: Species
name: Sulfate derivative of norepinephrine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1

metaR r2091
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110060#

metaR r0523
kinetic law: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000176
reversible: false
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:

metaM HC02207 e
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: prostaglandin-c2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false
boundary condition: false
type: Species
is: CHEBI:27555

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_7e479275_4e09_4620_96e8_63bcf39eb2dd
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: CA14
is: A8K3J4
is encoded by: hsa:23632

metaR SERDGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
modifier: MODEL1310110060#
name: D-Serine/Glutamine reversible exchange
reversible: true
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
is: SBO:0000185

metaM pro D c
boundary condition: false
constant: false
is: SBO:0000247
name: D-proline
has only substance units: false
is: HMDB03411
is: CHEBI:16313
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
type: Species

metaR KYNATESYN
kinetic law: MODEL1310110060#
is: SBO:0000176
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
fast: false
reactant: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000
product: MODEL1310110060#
type: Reaction

metaR Htx
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
name: H transporter, peroxisome
kinetic law: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_1aa0015e_4fd3_4d5d_aee1_99fef8768b5e
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:53354
has only substance units: false
constant: false
boundary condition: true
name: PANK1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_4b6fc24c_a8f9_4dfc_bdf6_801d927b9c76
is encoded by: hsa:5538
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q6FGQ4
name: PPT1
initial concentration: NaN
constant: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaM retinal cis 9 r
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01358
is: CHEBI:17898
initial concentration: 1.0
initial amount: NaN
constant: false
name: all-trans-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
type: Species

metaR r0668
is: SBO:0000176
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.2.19
type: Reaction
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
fast: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:

metaR RE2999M
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE2999
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8

metaR r2092
product: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR r0522
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: false
type: Reaction
product: MODEL1310110060#
is: SBO:0000176
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
modifier: MODEL1310110060#
reactant: MODEL1310110060#

metaR RE3243R
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110060#
reversible: true
name: RE3243
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_3db57a91_ac65_4dc5_b8bc_7ba63af4c144
constant: false
type: Species
is: P10696
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:251
name: ALPPL2
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM val L e
is: HMDB00883
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:16414
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-valine

http://identifiers.org/biomodels.db/MODEL1310110060#_652c3089_0871_43b8_9462_43762dd47e8a
type: Species
boundary condition: true
is encoded by: hsa:5151
name: PDE8A
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaR r1154
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
reversible: true
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110060#
name: EC:1.2.7.2

metaM CE0693 m
is: HMDB11123
is: SBO:0000247
is: CHEBI:28387
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: 3-oxolaur-6-cis-enoyl-CoA
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693

metaM xu5p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
name: D-xylulose 5-phosphate(2-)
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: CHEBI:57737
initial amount: NaN
initial concentration: 1.0
is: HMDB00868

metaM fum m
initial concentration: 1.0
type: Species
initial amount: NaN
name: Fumarate
boundary condition: false
is: C00122
constant: false
is: CHEBI:29806
has only substance units: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: SBO:0000247
is: HMDB00134

metaR FE3MTP1
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000134
name: transport of ferrous iron into blood
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
product: MODEL1310110060#

metaR HMGCOASim
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
reversible: false
name: Hydroxymethylglutaryl CoA synthase (ir)
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
fast: false
kinetic law: MODEL1310110060#

metaR MGSA
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: methylglyoxal synthase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110060#

metaM octa c
initial amount: NaN
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
is: CHEBI:25646
is: C06423
initial concentration: 1.0
constant: false
name: octanoate (n-C8:0)
is: HMDB00482
is: SBO:0000247
type: Species
has only substance units: false

metaR GALASE12ly
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
modifier: MODEL1310110060#
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110060#

metaR OLEICFATPtc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_2c1fd0aa_2a2a_4b7d_9365_4dd8e90c8ef3
is encoded by: hsa:218
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P30838
type: Species
constant: false
is: SBO:0000252
name: ALDH3A1
initial amount: NaN

metaM nrpphrsf c
initial amount: NaN
name: Sulfate derivative of norepinephrine
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: HMDB02062
is: SBO:0000247
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/123747

metaR r0735
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
modifier: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaM thym c
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
is: CHEBI:17821
name: Thymine
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: C00178

metaR r1571
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM btamp c
constant: false
is: CHEBI:3110
name: Biotinyl-5'-AMP
type: Species
has only substance units: false
initial amount: NaN
is: HMDB04220
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial concentration: 1.0

metaR RE2972M
reversible: true
name: RE2972
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.1.67
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
modifier: MODEL1310110060#

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR HMGCOAtm
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
is described by: ECO:0000000
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_12d6677b_e197_48ee_8835_2c60f6b3363c
name: ADA
is encoded by: hsa:100
boundary condition: true
is: SBO:0000252
is: P00813
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_8b9933d8_ac1c_44ba_9325_d2ef08df4e7f
name: _AI656480_1_m
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI656480
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR SPH1Pte
type: Reaction
reactant: MODEL1310110060#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: sph1p transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_9ef2accc_2f92_4de2_83bb_ce9d3412c302
initial amount: NaN
is: Q13057
is: SBO:0000252
constant: false
is encoded by: hsa:80347
has only substance units: false
boundary condition: true
initial concentration: NaN
name: COASY
type: Species

metaM hs deg23 l
is: CHEBI:21338
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H49NO29S CHARGE: -2
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB02704

metaM urcan c
type: Species
constant: false
initial amount: NaN
is: HMDB00301
name: Urocanate
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: CHEBI:17771
is: C00785
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r0210
kinetic law: MODEL1310110060#
name: L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 0 AUTHORS: PMID:681363 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110060#
reversible: false

metaM nicrns c
type: Species
has only substance units: false
initial amount: NaN
is: HMDB06809
name: Nicotinate D-ribonucleoside
constant: false
is: SBO:0000247
is: CHEBI:58527
initial concentration: 1.0
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
boundary condition: false

metaR r1570
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
type: Reaction

metaR r0734
kinetic law: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
product: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000

metaR RE0944E
name: RE0944
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
fast: false
is: SBO:0000176
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true

metaM thym e
is: SBO:0000247
has only substance units: false
name: thymine
type: Species
is: CHEBI:17821
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial concentration: 1.0
is: HMDB00262

http://identifiers.org/biomodels.db/MODEL1310110060#_292af553_d0c5_4ad9_ab58_2f9ec212b6d6
constant: false
initial amount: NaN
boundary condition: true
is: Q86VV3
type: Species
is: SBO:0000252
name: ENTPD1
is encoded by: hsa:953
has only substance units: false
initial concentration: NaN

metaR HIStiDF
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reversible: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
reactant: MODEL1310110060#
name: L-histidine transport via diffusion (extracellular to cytosol)

metaR L LACt4r
reversible: true
is: SBO:0000185
name: L-lactate reversible transport via sodium symport
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reactant: MODEL1310110060#

metaR r0590
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM arachd c
is: HMDB01043
boundary condition: false
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: arachidonate
is: CHEBI:32395

http://identifiers.org/biomodels.db/MODEL1310110060#_30b63565_4a9f_49be_a81b_823de5d5143b
has only substance units: false
name: NAE1
boundary condition: true
is: A8MU28
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8883
initial concentration: NaN

metaR RE1448N
name: RE1448
reactant: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
kinetic law: MODEL1310110060#
type: Reaction
fast: false

metaM ditp n
is: HMDB03537
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial amount: NaN
name: dITP(4-)
is: CHEBI:61382
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_fbac2a39_8c21_4b6d_bdf4_725b640d9683
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q86SK9
name: SCD5
is encoded by: hsa:79966
initial concentration: NaN

metaR 7DHCHSTEROLtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110060#
reversible: true
name: cholesterol precursor intracellular transport
product: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110060#
type: Reaction
fast: false

metaM glx m
initial concentration: 1.0
boundary condition: false
is: HMDB00119
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
type: Species
initial amount: NaN
is: CHEBI:36655
has only substance units: false
name: glyoxylate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_7eb5ab25_8f5d_4e05_ac50_11cf944b9124
initial concentration: NaN
name: SLC1A4
is encoded by: hsa:6509
has only substance units: false
boundary condition: true
initial amount: NaN
is: P43007
type: Species
is: SBO:0000252
constant: false

metaM HC02020 r
is: CHEBI:3663
name: Cholesterol-ester-palm
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
initial amount: NaN
boundary condition: false

metaR r0733
product: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
reversible: false

metaM Rtotal3 e
name: R total 3 position
initial amount: NaN
has only substance units: false
is: HMDB00244
boundary condition: false
is: CHEBI:3554
is: C00255
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

metaR r1573
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_0c6a43dc_b77d_4be2_adbd_70b05473036d
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _AI971036_1_m
has only substance units: false
constant: false
type: Species
is encoded by: hsa:AI971036

http://identifiers.org/biomodels.db/MODEL1310110060#_22f49fb8_f08a_49bc_9955_e1b75264b67d
type: Species
is: SBO:0000297
boundary condition: true
is encoded by: hsa:7991
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM creat e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
constant: false
type: Species
is: HMDB00064
name: creatine
has only substance units: false
is: SBO:0000247
is: CHEBI:16919

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM ksi deg10 l
is: CHEBI:57455
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01354
has only substance units: false
name: keratan sulfate I, degradation product 10

metaM nadh c
is: C00004
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
type: Species
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306

http://identifiers.org/biomodels.db/MODEL1310110060#_7e75ecc6_38e5_4d63_8344_b13267a9fce0
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5150
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: PDE7A
constant: false
is: Q13946

http://identifiers.org/biomodels.db/MODEL1310110060#_181d5047_cb2f_414e_be2b_e54b006f3161
initial concentration: NaN
has only substance units: false
type: Species
is: Q9HCR9
boundary condition: true
is encoded by: hsa:50940
constant: false
initial amount: NaN
is: SBO:0000252
name: PDE11A

metaR FATP3t
reactant: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110060#
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110060#
name: fatty acid electroneutral transport

http://identifiers.org/biomodels.db/MODEL1310110060#_9d2d4385_d4d0_4ed3_9b4e_17b8bd470a5f
is: P16930
constant: false
type: Species
has only substance units: false
name: FAH
initial amount: NaN
is encoded by: hsa:2184
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r0591
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110060#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
kinetic law: MODEL1310110060#
fast: false
reversible: true
modifier: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
is described by: ECO:0000000

metaR r0946
product: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110060#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_cc47d810_08aa_4272_be69_5e00fb7045aa
is: Q16836
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3033
type: Species
constant: false
initial amount: NaN
name: HADH

metaR r0732
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_511baccf_ebd7_4787_a6c5_430f4b7bc095
initial amount: NaN
type: Species
name: GUCY1B2
is: SBO:0000252
constant: false
is encoded by: hsa:2974
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM dxtrn c
is: SBO:0000247
is: HMDB00127
initial amount: NaN
notes: FORMULA: C48H81O41X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02135
is: CHEBI:15748
constant: false
type: Species
name: phosphorylase-limit dextrin (glycogenin-1,6{4[1,4-Glc], 4[1,4-Glc]})
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a5d90f94_861f_489e_aa65_a13459312b20
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: B3GNT7
is: Q8NFL0
is encoded by: hsa:93010
has only substance units: false

metaM HC01415 m
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:27537
boundary condition: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
name: (2E)-Octenoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_15ee7bbc_d5c0_4e4a_8e05_5408a91ec9b7
boundary condition: true
is encoded by: hsa:4720
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: B7Z792
type: Species
name: NDUFS2
initial amount: NaN

metaR TYRTA
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
is described by: ECO:0000269
reactant: MODEL1310110060#
is: SBO:0000176
name: tyrosine transaminase
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#

metaR NDPK2
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
modifier: MODEL1310110060#
name: nucleoside-diphosphate kinase (ATP:UDP)
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR r1631
fast: false
is: SBO:0000185
reactant: MODEL1310110060#
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM fprica c
boundary condition: false
is: CHEBI:58467
initial concentration: 1.0
is: C04734
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01439

metaR r0644
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
fast: false

metaR EX gltcho LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for beta glucan-taurocholic acid complex
type: Reaction

metaR r2534
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000

metaM lnlncgcoa r
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
type: Species
initial amount: NaN
is: CHEBI:57363
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368

http://identifiers.org/biomodels.db/MODEL1310110060#_4e7f79a8_0dba_488a_aa7b_f4fb361d55ad
boundary condition: true
name: GANC
constant: false
initial amount: NaN
has only substance units: false
is: Q8TET4
is: SBO:0000252
type: Species
is encoded by: hsa:2595
initial concentration: NaN

metaM arg L c
type: Species
is: SBO:0000247
constant: false
name: L-argininium(1+)
initial amount: NaN
is: CHEBI:32682
is: HMDB00517
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false

metaM dcholcoa c
initial amount: NaN
initial concentration: 1.0
name: chenodeoxycholoyl coenzyme a
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
is: HMDB06292
is: CHEBI:28701

http://identifiers.org/biomodels.db/MODEL1310110060#_43a28b43_16df_4fd2_8d80_15efa5522a60
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80271
type: Species
is: Q96DU7
name: ITPKC
boundary condition: true

metaM ksi pre14 g
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 14
boundary condition: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
is: CHEBI:28067
type: Species

metaR S6T8g
type: Reaction
is: SBO:0000176
product: MODEL1310110060#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110060#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110060#

metaM thp2c x
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
is: HMDB12130
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 1-piperideine-6-carboxylate
type: Species
is: CHEBI:16987
initial concentration: 1.0
boundary condition: false

metaM 20ahchsterol m
initial concentration: 1.0
initial amount: NaN
is: HMDB06283
constant: false
is: SBO:0000247
is: CHEBI:1296
type: Species
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
boundary condition: false
name: 20-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110060#_a666bd95_7155_49da_8866_f7788fb1fb0e
has only substance units: false
boundary condition: true
type: Species
is: Q9P1E4
is: SBO:0000252
is encoded by: hsa:4122
name: MAN2A2
constant: false
initial concentration: NaN
initial amount: NaN

metaM CE5786 e
is: SBO:0000247
has only substance units: false
is: HMDB02710
initial concentration: 1.0
name: kinetensin
boundary condition: false
type: Species
is: CHEBI:27485
constant: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_50cc059d_f6e8_48e1_9e9e_d7d122c7285d
initial amount: NaN
boundary condition: true
is: P20674
is: SBO:0000252
has only substance units: false
name: COX5A
is encoded by: hsa:9377
type: Species
initial concentration: NaN
constant: false

metaM sphs1p c
has only substance units: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
is: SBO:0000247
is: HMDB00277
type: Species
boundary condition: false
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
initial amount: NaN
is: CHEBI:60119

http://identifiers.org/biomodels.db/MODEL1310110060#_70f1087f_80c5_461a_a707_4349f2b8522b
constant: false
boundary condition: true
has only substance units: false
is: Q9BT22
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:56052
is: SBO:0000252
name: ALG1
type: Species

metaR r1259
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
is: SBO:0000176
reactant: MODEL1310110060#
fast: false
type: Reaction
is described by: ECO:0000000
name: EC:6.2.1.3

metaR r1632
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#

metaR NDPK3
kinetic law: MODEL1310110060#
reversible: true
fast: false
name: nucleoside-diphosphate kinase (ATP:CDP)
type: Reaction
modifier: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269

metaR r0547
reactant: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.1.4
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110060#

metaR r2535
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
is: SBO:0000185

metaM CE5854 e
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB02710
name: gama-CEHC-glucuronide
is: CHEBI:27485
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854

http://identifiers.org/biomodels.db/MODEL1310110060#_726f9fc2_339c_4de7_b11a_919f9cd9f0fc
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3028
name: HSD17B10
initial concentration: NaN
is: Q99714
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR CYTK13n
fast: false
name: cytidylate kinase (dCMP,dATP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaM xol7aone m
is: HMDB01993
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17899
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial amount: NaN

metaR LEUTA
name: leucine transaminase
type: Reaction
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
modifier: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM pac c
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: phenylacetate
type: Species
is: CHEBI:18401
is: HMDB00209
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial amount: NaN
constant: false

metaM ala L m
is: CHEBI:16977
constant: false
type: Species
initial amount: NaN
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00161

http://identifiers.org/biomodels.db/MODEL1310110060#_2fd47349_0900_4024_a1c0_2f20fddd1309
name: B4GALT2
is encoded by: hsa:8704
boundary condition: true
is: O60909
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_eb17ba17_86e5_4163_8a2e_738f3d4d0769
constant: false
is encoded by: hsa:3162
boundary condition: true
type: Species
initial amount: NaN
name: HMOX1
has only substance units: false
initial concentration: NaN
is: Q6FH11
is: SBO:0000252

metaM thr L c
initial amount: NaN
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16857
is: HMDB00167
has only substance units: false
boundary condition: false
type: Species

metaR NDPK4
reversible: true
product: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000269

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_091b6953_1e75_4303_80ac_0c5e6d017f40
constant: false
type: Species
is: B4DK61
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ACOX1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51

http://identifiers.org/biomodels.db/MODEL1310110060#_b910a379_4965_47b3_9b8b_b7664a084502
name: _AA526438_1_c
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA526438
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaR r1633
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM hyptaur c
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
name: Hypotaurine
initial concentration: 1.0
is: HMDB00965
is: CHEBI:16668
has only substance units: false

metaM fuc L l
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00174
initial concentration: 1.0
has only substance units: false
type: Species
name: L-fucose
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

metaR FE2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
fast: false
product: MODEL1310110060#
name: iron (II) transport
reversible: false
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000185

metaM CE2422 m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
has only substance units: false
initial concentration: 1.0
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: HMDB11123
constant: false
type: Species
is: CHEBI:28387
initial amount: NaN

metaM phe L c
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine
is: SBO:0000247
is: CHEBI:17295
constant: false
is: HMDB00159
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

metaM arg L e
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: L-argininium(1+)
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: CHEBI:32682

metaM gchola e
type: Species
is: HMDB00138
notes: FORMULA: C26H43NO6 CHARGE: 0
name: glycocholate
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_e002e924_1cd5_48fa_bd64_6a3f1e826e9f
name: MGAT2
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q10469
is encoded by: hsa:4247
initial amount: NaN

metaR NAIt
modifier: MODEL1310110060#
fast: false
name: Na+ / iodide cotransport
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
reversible: true
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaR NACHEXA14ly
modifier: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

http://identifiers.org/biomodels.db/MODEL1310110060#_26b30f76_cddf_4ed4_9f8b_6fb78a8a39e0
type: Species
boundary condition: true
is encoded by: hsa:4731
name: NDUFV3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaM accoa n
is: HMDB01206
has only substance units: false
constant: false
name: acetyl-CoA(4-)
initial amount: NaN
is: CHEBI:57288
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_ac822adf_0133_4cd7_b612_5ba601affbb4
boundary condition: true
name: GCK
is encoded by: hsa:2645
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaR INSTt4 2
reversible: true
is described by: ECO:0000006
name: inositol transport via sodium symport
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
fast: false
modifier: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_31e8f25e_8d4a_4389_b207_08ca6ce33c9d
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: GCK
boundary condition: true
initial amount: NaN
is encoded by: hsa:2645
is: Q53Y25
initial concentration: NaN

metaR NDPK5
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dGDP)
is: SBO:0000176
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true

metaR r2537
product: MODEL1310110060#
name: Utilized transport
reactant: MODEL1310110060#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaR r0549
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/6.1.1.17
reactant: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_dd21b6dc_67ea_4579_b9eb_897b60b97e79
initial amount: NaN
is encoded by: hsa:51268
initial concentration: NaN
is: Q9P0Z9
constant: false
has only substance units: false
is: SBO:0000252
name: PIPOX
boundary condition: true
type: Species

metaM sphs1p e
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00277
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:60119
initial concentration: 1.0

metaR GLCNACT U
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
type: Reaction
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_eb8a87d2_e0c8_4c02_abc2_2b1aada884ee
has only substance units: false
is: F5H2Y9
is encoded by: hsa:8854
initial amount: NaN
is: SBO:0000252
type: Species
name: ALDH1A2
constant: false
boundary condition: true
initial concentration: NaN

metaR r1634
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR TCYNTt
name: Thiocyanate transport via diffusion (cytosol to extracellular)
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_32345d1b_e4c4_44bf_9a4a_c7d97eebe531
constant: false
has only substance units: false
name: PDE4A
initial concentration: NaN
is encoded by: hsa:5141
type: Species
is: P27815
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_0225c69e_7dcd_4646_99b6_3fde6c112163
is: Q549M5
initial amount: NaN
is encoded by: hsa:4718
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: NDUFC2

metaM glygn2 c
has only substance units: false
is: HMDB06355
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18268
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})

metaR PI34P5K
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
reactant: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
fast: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reversible: false
is: SBO:0000176

metaM uri n
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: uridine
is: CHEBI:16704
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
is: HMDB00296
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_de1d7ea9_6404_42c7_b6e0_b2a19320dde3
name: MPST
boundary condition: true
has only substance units: false
is encoded by: hsa:4357
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P25325
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_fd9bd3f3_a0c8_4015_8778_f10666b95ab2
is: Q99755
boundary condition: true
is encoded by: hsa:8394
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: PIP5K1A
is: SBO:0000252
initial concentration: NaN

metaM ksi pre4 g
is: HMDB00175
has only substance units: false
is: SBO:0000247
constant: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 4
is: CHEBI:58053
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C101H165N7O72X CHARGE: -1
initial amount: NaN

metaR r2389
modifier: MODEL1310110060#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM phe L e
is: CHEBI:17295
name: L-phenylalanine
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB00159

metaR r1635
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CYANt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
name: Cyanide transport via diffusion (extracellular to cytosol)
is: SBO:0000185
reversible: true

metaR NDPK6
kinetic law: MODEL1310110060#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_c9b81863_e22d_49db_9291_bd03d24d387a
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: TXNRD1
initial concentration: NaN
constant: false
is encoded by: hsa:7296

metaR G13MT U
is described by: ECO:0000000
is: SBO:0000176
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.132
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_e9e6f7f0_0f8c_4830_90b9_af43edc3449c
is encoded by: hsa:221
initial concentration: NaN
boundary condition: true
name: ALDH3B1
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: P43353
is: SBO:0000252

metaR FUCASE2ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000176
product: MODEL1310110060#
fast: false
name: alpha-fucosidase, lysosomal
modifier: MODEL1310110060#

metaR DOLPGT1 Uer
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110060#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.267
reversible: false
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_4608326d_4393_4459_b4b7_706c05e13e05
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: _NM_013421_1_e
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:NM 013421

metaR r2133
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_f69964c3_08f2_434f_ad46_cad71bbbd25e
constant: false
name: _AI222095_1_m
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI222095
boundary condition: true

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaM o2s x
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: superoxide
is: CHEBI:18421
initial concentration: 1.0
is: HMDB02168
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaR GALASE5ly
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110060#
reversible: false
is: SBO:0000176
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR LTA4H
is version of: http://identifiers.org/ec-code/3.3.2.6
fast: false
name: Leukotriene A-4 hydrolase
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
is: SBO:0000176
reversible: false
product: MODEL1310110060#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ

metaM nadp m
boundary condition: false
is: CHEBI:58349
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_98c23627_4e01_46aa_aa78_4a5054da9cab
constant: false
is: SBO:0000252
type: Species
name: RDH5
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:5959
boundary condition: true
is: Q92781

metaM gchola c
constant: false
boundary condition: false
is: CHEBI:58235
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
type: Species
name: glycocholate
is: HMDB00138
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR r2388
reversible: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaM xoldiolone c
has only substance units: false
is: CHEBI:28477
boundary condition: false
is: HMDB02197
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457

http://identifiers.org/biomodels.db/MODEL1310110060#_41b51b17_4839_47a0_bf91_6fee956ae4a2
initial amount: NaN
constant: false
type: Species
name: COX7B
has only substance units: false
boundary condition: true
is: P24311
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1349

metaR r1636
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110060#

metaR D LACt2
modifier: MODEL1310110060#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110060#
name: D-lactate transport via proton symport
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM spmd e
initial amount: NaN
type: Species
constant: false
has only substance units: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: C00315
name: Spermidine
is: HMDB01257
is: CHEBI:57834
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_2dc0b302_a629_4314_9c5d_ecc9cade8496
is: SBO:0000252
is encoded by: hsa:AI935189
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: _AI935189_1_m
initial amount: NaN

metaR NDPK7
is described by: ECO:0000269
reactant: MODEL1310110060#
product: MODEL1310110060#
name: nucleoside-diphosphate kinase (ATP:dCDP)
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true

metaM HC02180 c
boundary condition: false
name: thromboxane-b2
is: CHEBI:28728
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
type: Species
constant: false
is: SBO:0000247

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR BGLUTCHLe
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of betaglucans with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR RE1836X
name: RE1836
reactant: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
kinetic law: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000000

metaR DGAT
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.20
is described by: ECO:0000000
reactant: MODEL1310110060#
reversible: false
fast: false
name: diacylglycerol acyltransferase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ

metaR r2132
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_8edc91a9_cd5d_4030_aef4_f096825f45be
has only substance units: false
boundary condition: true
name: PDE9A
type: Species
is encoded by: hsa:5152
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaM dopasf c
is: HMDB06275
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: dopamine 3-O-sulfate
constant: false
is: CHEBI:37946
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
type: Species
has only substance units: false

metaM HC00460 c
initial amount: NaN
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
initial concentration: 1.0
is: CHEBI:58044
boundary condition: false
constant: false
type: Species
has only substance units: false
name: 2,5-dihydroxybenzoate
is: SBO:0000247

metaR AHCYStd
type: Reaction
name: diffusion of S-Adenosyl-L-homocysteine
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
reversible: true
is: SBO:0000185

metaR r0181
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
is: SBO:0000176

metaM sucsal m
initial concentration: 1.0
constant: false
is: CHEBI:57706
name: Succinic semialdehyde
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: HMDB01259
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_cd5cc8bd_3763_498c_bbec_1fbd6af41696
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2530
is: G3V5N0
constant: false
name: FUT8
initial concentration: NaN

metaR r0224
product: MODEL1310110060#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110060#
reversible: false
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110060#

metaR RE1898C
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
name: RE1898
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_4785894a_d808_4041_873c_4f3ef79871a4
is encoded by: hsa:8854
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: ALDH1A2
is: O94788
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_0d3cca89_6528_47a5_a78d_9d5d6b20a699
is encoded by: hsa:7991
has only substance units: false
is: Q13454
initial amount: NaN
initial concentration: NaN
constant: false
name: TUSC3
type: Species
boundary condition: true
is: SBO:0000252

metaR r0642
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaR r2532
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000

metaR NDPK8
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
fast: false
name: Nucleoside-diphosphate kinase (ATP:dADP)

metaM hdcea e
constant: false
is: HMDB03229
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Hexadecenoate (n-C16:1)
is: CHEBI:32372
is: SBO:0000247
initial amount: NaN
type: Species

metaR CYTK3n
modifier: MODEL1310110060#
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110060#
name: cytidylate kinase (dCMP,CTP),nuclear
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110060#

metaM ksii core2 pre7 g
is: HMDB00175
is: CHEBI:58053
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C67H108N5O51SX CHARGE: -2
has only substance units: false
initial amount: NaN
is: C00130
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
initial concentration: 1.0

metaM gthrd c
boundary condition: false
initial amount: NaN
name: Reduced glutathione
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
type: Species
is: C00051
is: CHEBI:57925
constant: false
is: HMDB00125
is: SBO:0000247

metaR r2131
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110060#
fast: false
reversible: true

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR ARACHDtr
product: MODEL1310110060#
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000000
name: intracellular transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_eaa4221e_2c0e_4b01_a30a_cd324a351c75
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: ACAT1
boundary condition: true
type: Species
is encoded by: hsa:38
is: P24752

metaM pmtcrn x
has only substance units: false
is: SBO:0000247
is: HMDB00222
type: Species
is: CHEBI:17490
name: L-palmitoylcarnitine
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
constant: false
initial concentration: 1.0

metaR LEUTAm
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is described by: ECO:0000269
type: Reaction
name: leucine transaminase, mitochondrial
kinetic law: MODEL1310110060#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_b601149f_f5af_4de8_90f5_6bbeb6b9524a
is: O15382
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: BCAT2
is encoded by: hsa:587

metaM b2coa m
type: Species
is: HMDB02009
constant: false
boundary condition: false
initial amount: NaN
name: crotonoyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57332
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
is: SBO:0000247
has only substance units: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR NADPtru
reversible: false
name: NADP transporter, endoplasmic reticulum
type: Reaction
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaR O2St
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
name: superoxide anion transport via diffusion (extracellular)
type: Reaction

metaR ORNt4m
modifier: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reversible: true
name: ornithine mitochondrial transport exchange with citruline
reactant: MODEL1310110060#
is: SBO:0000185
fast: false

metaR ACALDtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110060#
fast: false
name: acetaldehyde mitochondrial diffusion
is: SBO:0000185
reactant: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#

metaR NDPK9
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
name: nucleoside-diphosphate kinase (ATP:IDP)
modifier: MODEL1310110060#

metaM ibcoa m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
is: HMDB01243
has only substance units: false
is: CHEBI:57338
is: SBO:0000247
constant: false
name: isobutyryl-CoA(4-)
type: Species

metaR r1638
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR r0641
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
product: MODEL1310110060#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4
is: SBO:0000176
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
reactant: MODEL1310110060#

metaM spmd c
boundary condition: false
is: C00315
initial amount: NaN
is: CHEBI:57834
is: HMDB01257
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Spermidine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f5854d8f_8e42_4b12_a6ad_0733cfe0c303
is encoded by: hsa:6120
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: RPE
has only substance units: false
is: Q53TV9
boundary condition: true

metaM HC01408 m
is: CHEBI:27648
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial amount: NaN
is: SBO:0000247
name: 3-Oxohexanoyl-CoA
has only substance units: false
constant: false

metaM nad m
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
initial amount: NaN
type: Species
name: Nicotinamide adenine dinucleotide
is: C00003
is: HMDB00902
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57540

metaM mercppyr c
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
name: 3-mercaptopyruvate
initial concentration: 1.0
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
is: CHEBI:57678
is: HMDB01368
is: SBO:0000247
constant: false

metaR r2130
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185

metaR r0545
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reactant: MODEL1310110060#
fast: false
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_d4be4695_c09c_487f_a281_8bc637738eb0
name: ST3GAL3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6487
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6ffad6a6_a07f_46a7_ad3b_957e51d41dcf
is encoded by: hsa:3418
type: Species
is: P48735
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: IDH2

metaR FAOXC16DCr
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_d96451ac_a6db_45fd_a0d5_fd2af6105a61
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11212
is: O94903
name: PROSC
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f5518308_0c02_4494_af68_a822bb4e1600
has only substance units: false
is: SBO:0000252
constant: false
is: Q6IBA0
name: NDUFS5
initial amount: NaN
boundary condition: true
is encoded by: hsa:4725
type: Species
initial concentration: NaN

metaM glygn3 c
initial concentration: 1.0
constant: false
is: CHEBI:15748
name: glycogen, structure 3 (glycogenin-7[1,4-Glc])
boundary condition: false
is: HMDB00127
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C42H71O36X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02137

http://identifiers.org/biomodels.db/MODEL1310110060#_5eae6d0b_3a15_4c2a_bc19_8fbabf7a6a70
initial concentration: NaN
type: Species
is encoded by: hsa:4541
is: Q7GXZ1
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: ND6
initial amount: NaN

metaM dopasf e
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:37946
initial concentration: 1.0
name: dopamine 3-O-sulfate
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
type: Species
is: HMDB06275

http://identifiers.org/biomodels.db/MODEL1310110060#_376dbd17_fb49_4e82_a667_3e53de1a1bac
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4731
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: P56181
has only substance units: false
name: NDUFV3

metaM HC01007 x
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:18102
initial amount: NaN
name: L-Octanoylcarnitine
boundary condition: false
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
constant: false
is: SBO:0000247

metaR RE3000M
modifier: MODEL1310110060#
name: RE3000
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reactant: MODEL1310110060#

metaM ksii core4 pre5 g
is: HMDB00175
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
constant: false
type: Species
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: CHEBI:58053
is: C00130

metaM HC01522 c
constant: false
name: Gentisate aldehyde
is: SBO:0000247
is: CHEBI:28508
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
has only substance units: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_70c8c137_f951_4e5b_bed9_bae752a224cd
constant: false
boundary condition: true
is: SBO:0000252
name: ITPA
type: Species
is: Q9BY32
is encoded by: hsa:3704
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM cbasp c
boundary condition: false
has only substance units: false
is: C00438
is: HMDB00828
type: Species
constant: false
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
initial amount: NaN
is: CHEBI:32814

metaR r2137
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#

metaR SIAASE4ly
is described by: ECO:0000000
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
product: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false

metaM Lpipecol x
is: HMDB00716
name: L-pipecolic acid
is: CHEBI:30913
initial amount: NaN
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_bd8a8608_74b6_4cbe_a673_2d319568a8e6
boundary condition: true
name: GALNT10
has only substance units: false
is encoded by: hsa:55568
is: Q86SR1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaM ksi deg38 l
has only substance units: false
name: keratan sulfate I, degradation product 38
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
boundary condition: false
is: SBO:0000247
is: CHEBI:12936
constant: false
type: Species
notes: FORMULA: C54H91N3O41 CHARGE: 0

metaR DUMPtn
name: dUMP nuclear transport
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185

metaM gthrd e
constant: false
is: HMDB00125
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: glutathionate(1-)
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
type: Species
boundary condition: false

metaM uri e
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
name: Uridine
constant: false
type: Species
initial amount: NaN
is: HMDB00296
is: C00299
is: CHEBI:16704

metaR RE2998M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: RE2998
modifier: MODEL1310110060#
reversible: false

metaR CPPPGO
fast: false
product: MODEL1310110060#
name: coproporphyrinogen oxidase (O2 required)
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.3.3
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
type: Reaction
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_5cd9a98c_57d4_4090_919a_875e4959c441
boundary condition: true
is encoded by: hsa:LOC728997
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: _LOC728997_1_c
has only substance units: false
initial amount: NaN

metaR r1744
reversible: false
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r2385
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000185

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_e6b0bd76_d791_4282_bf83_46d88a4ee72c
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:AI285872
is: SBO:0000252
name: _AI285872_1_c
boundary condition: true
type: Species
has only substance units: false

metaM ala L e
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: CHEBI:16977
name: L-alanine
boundary condition: false
constant: false
is: HMDB00161
is: SBO:0000247
type: Species
initial amount: NaN

metaR AMETtd
name: diffusion of S-Adenosyl-L-methionine
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110060#
fast: false
is described by: ECO:0000134

metaM CE4872 c
is: CHEBI:15748
constant: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: HMDB00127
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_ab652b12_1d40_4cf7_8eb5_7a05fe12bcac
has only substance units: false
name: _AI697028_1_e
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI697028

http://identifiers.org/biomodels.db/MODEL1310110060#_2a07a862_0e84_4001_9abc_bd97fff171d8
is: P22033
name: MUT
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:4594
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM ksi deg2 l
is: HMDB01166
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
is: CHEBI:57316
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I, degradation product 2
type: Species
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_c08cd704_3159_48f1_a198_8c0d147d0878
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q05C14
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2352
constant: false
name: FOLR3

metaM hdcea r
is: CHEBI:32372
is: HMDB03229
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: palmitoleate
constant: false
type: Species

metaR ACITL
is version of: http://identifiers.org/ec-code/2.3.3.8
modifier: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is described by: ECO:0000000
name: ATP-Citrate lyase
fast: false
is: SBO:0000176
product: MODEL1310110060#

metaR r0434
kinetic law: MODEL1310110060#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
reactant: MODEL1310110060#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false

metaM CE2431 m
is: CHEBI:57795
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
constant: false
name: cis-deca-4-enoyl-CoA

metaM met L c
type: Species
constant: false
is: SBO:0000247
is: HMDB00696
initial amount: NaN
has only substance units: false
is: CHEBI:16643
name: L-methionine
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0

metaR ASPTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
is: SBO:0000176
type: Reaction
name: aspartate transaminase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false

metaM cbasp e
constant: false
has only substance units: false
is: CHEBI:32814
type: Species
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
boundary condition: false
initial concentration: 1.0
is: HMDB00828
initial amount: NaN
is: C00438

metaM fuc L c
initial concentration: 1.0
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial amount: NaN
constant: false
name: L-fucose
has only substance units: false
is: HMDB00174
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:18287

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR GLYCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
reversible: true
name: glycerol transport via channel
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a37e1fce_5f13_4c6d_901e_8e270f2ec656
initial amount: NaN
initial concentration: NaN
type: Species
has part: E5KS60
has only substance units: false
is encoded by: hsa:8803
constant: false
boundary condition: true
name: SUCLG1:SUCLA2
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110060#_2d606685_bfcb_4eaf_a1dd_b951f0b1a7fa
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: P37837
initial amount: NaN
name: TALDO1
is encoded by: hsa:6888
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_3f9c2f2e_3a98_468b_a961_0c2e841ccb93
initial amount: NaN
type: Species
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
is encoded by: hsa:5147
boundary condition: true
has part: O43924
has only substance units: false
has part: P18545
initial concentration: NaN
is encoded by: hsa:5148
constant: false
is: SBO:0000297

metaR NICRNS
type: Reaction
fast: false
reversible: false
product: MODEL1310110060#
name: NICRNS
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
is: SBO:0000176
is described by: ECO:0000000

metaR r1858
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_c97bc529_bfd7_4343_afa6_6dd0bd8bbbbc
name: ST3GAL3
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6487
is: B4DX62
type: Species
boundary condition: true

metaR r0156
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
reversible: false
is described by: ECO:0000000
fast: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15

metaR r1745
reversible: false
type: Reaction
reactant: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#

metaR r2497
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
fast: false
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
kinetic law: MODEL1310110060#

metaR r2384
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_e659964d_2e2a_4690_8685_434c7e263a27
type: Species
name: PLCE1
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51196
is: Q9P212
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_2ffb9a74_e8fd_4e42_aa22_a13cbcfcd7ad
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4729
is: P19404
initial concentration: NaN
name: NDUFV2
boundary condition: true
initial amount: NaN

metaR CHATn
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.6
modifier: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
fast: false
reactant: MODEL1310110060#

metaR AICARte
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000185
fast: false
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

metaM nadp c
type: Species
boundary condition: false
has only substance units: false
is: HMDB00217
initial concentration: 1.0
is: C00006
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
is: CHEBI:58349
constant: false

metaM ppp9 m
boundary condition: false
is: HMDB00241
type: Species
has only substance units: false
name: Protoporphyrin
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:36159
initial amount: NaN

metaR COt
is described by: ECO:0000000
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#
name: CO transporter via diffusion
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reversible: true
kinetic law: MODEL1310110060#

metaM HC00361 c
is: CHEBI:58335
type: Species
constant: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
boundary condition: false
name: sedoheptulose 1,7-bisphosphate(4-)
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM tcynt c
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
is: CHEBI:18022
type: Species
boundary condition: false
name: thiocyanate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_9da364c0_f874_4969_945a_ecc25e95a8c4
boundary condition: true
is encoded by: hsa:4704
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: NDUFA9
is: Q16795
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_4fe1f0c4_3f4b_45b8_9783_4e09ca7098d3
is encoded by: hsa:117247
type: Species
is: SBO:0000252
constant: false
is: Q8TF71
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC16A10
initial concentration: NaN

metaR S6TASE14ly
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false
reversible: true
modifier: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_a727bae3_04b3_4c84_993b_80db073441a6
is: P11498
name: PC
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5091
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_da2ed985_05b4_4cdf_8b18_ae41067c023b
is encoded by: hsa:6482
is: SBO:0000252
name: ST3GAL1
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: Q11201
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_15b21817_d81b_4816_af61_67d5ec597c6b
is: Q8IXW6
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:1809
name: DPYSL3

metaR r0974
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
name: Active transport
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#

metaR r1746
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110060#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
type: Reaction

metaM 5aop c
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 5-Amino-4-oxopentanoate
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: C00430
is: HMDB01149
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17549

metaR FACOAL224
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
name: fatty-acid--CoA ligase
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110060#

metaR r2387
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
fast: false
product: MODEL1310110060#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110060#
is: SBO:0000185

metaR NACHEX14ly
is described by: ECO:0000000
reactant: MODEL1310110060#
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110060#
reversible: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110060#
is: SBO:0000176
fast: false

metaM pro L m
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
is: CHEBI:17203
name: L-proline
is: SBO:0000247
type: Species
initial amount: NaN

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_4ad565d6_64b9_4e42_853c_069dab9323e3
type: Species
boundary condition: true
name: SLC2A9
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:56606

http://identifiers.org/biomodels.db/MODEL1310110060#_c0676a09_751d_4405_b973_f9a490687baf
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:64077
is: SBO:0000252
initial amount: NaN
is: Q9H008
name: LHPP
has only substance units: false

metaM doldp U r
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:15750
initial amount: NaN
name: Dolichol diphosphate, human uterine homolog
has only substance units: false
boundary condition: false
type: Species

metaM pan4p c
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: C01134
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Pantetheine 4'-phosphate
is: CHEBI:47942
constant: false
initial amount: NaN
type: Species

metaM pap g
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
name: adenosine 3',5'-bismonophosphate(4-)
initial amount: NaN
is: CHEBI:58343
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00061
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_71e886a3_203a_4b5a_8303_ad2d0af942ee
initial concentration: NaN
name: SLCO3A1
is encoded by: hsa:28232
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: Q9UIG8

http://identifiers.org/biomodels.db/MODEL1310110060#_2fa2611b_2fd8_420c_9555_f46833d23dcc
has only substance units: false
initial amount: NaN
boundary condition: true
name: ALDH7A1
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: E7EPT3
is encoded by: hsa:501

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaM HC02180 e
type: Species
name: thromboxane-b2
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:28728
boundary condition: false

metaM xoldiolone r
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: CHEBI:28477
initial concentration: 1.0
type: Species
is: HMDB02197
boundary condition: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial amount: NaN

metaR GLYBtm
reversible: true
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
reactant: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM

metaM HC01496 m
name: 2-Amino-3-oxoadipate
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: CHEBI:28095

http://identifiers.org/biomodels.db/MODEL1310110060#_80d129b3_c1e8_494f_ae9b_ce07077f9744
is encoded by: hsa:6531
initial concentration: NaN
constant: false
type: Species
is: Q01959
boundary condition: true
name: SLC6A3
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_24d90291_f4e3_40c5_82d1_d311cf694491
type: Species
name: SLC17A1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:6568
constant: false
is: SBO:0000252
is: Q14916
has only substance units: false

metaR SQLSr
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.21
reversible: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000134
name: Squalene synthase

metaR r2386
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false

metaR r0541
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
reversible: true
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is: SBO:0000176
fast: false
modifier: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM CE2839 e
constant: false
is: C01936
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
type: Species
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
name: maltodecaose
boundary condition: false
initial amount: NaN

metaM sphings c
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
type: Species
name: sphingosine(1+)
is: SBO:0000247
is: HMDB00252
is: CHEBI:57756
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_dd8e1c21_d2a5_4d24_8edf_f67801dce42f
initial concentration: NaN
has only substance units: false
name: ADCY6
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:112
type: Species
constant: false
is: O43306

http://identifiers.org/biomodels.db/MODEL1310110060#_9a9da307_576c_45ca_b25d_53b0faf72507
is: Q86TM7
initial amount: NaN
name: DPM3
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54344
type: Species

metaM nadp e
name: NADP+(3-)
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 INCHI: InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p-3/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:58349
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_7528cf25_0354_42e7_ad2a_ad5ee9aa1b2a
type: Species
is: B7Z4Y6
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ALPL
has only substance units: false
is encoded by: hsa:249
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_61d5342a_2006_47da_b5bb_89a666545648
type: Species
name: AGL
constant: false
is: SBO:0000252
is encoded by: hsa:178
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR AICART
modifier: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is described by: ECO:0000269

metaR DALAt2r
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
kinetic law: MODEL1310110060#
name: D-alanine transport via proton symport
reversible: true

metaM csn e
type: Species
initial amount: NaN
is: CHEBI:16040
name: cytosine
constant: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00630

http://identifiers.org/biomodels.db/MODEL1310110060#_cacc99db_5653_4900_8581_506e5fa4fffc
has part: P33402
is encoded by: hsa:2983
is encoded by: hsa:2977
type: Species
initial amount: NaN
has part: Q02153
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000297
name: GUCY1A2:GUCY1B3

metaR r0437
is described by: ECO:0000000
modifier: MODEL1310110060#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_bca5db27_3de7_473f_ac6a_f9e22129e6f4
boundary condition: true
is encoded by: hsa:2222
is: P37268
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: FDFT1

metaR r2538
reversible: true
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#

metaM tcynt e
is: SBO:0000247
boundary condition: false
name: thiocyanate
initial concentration: 1.0
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: CHEBI:18022
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01453

metaR G14T4g
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110060#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110060#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_0bec37bd_88dc_4f3b_bafe_ae93af601867
initial concentration: NaN
is: Q96C36
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PYCR2
is encoded by: hsa:29920

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propenoyl-CoA hydrolase (m)
reactant: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110060#
reversible: false

metaR ITCOAL1m
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110060#
fast: false
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#

metaM accoa m
is: HMDB01206
is: CHEBI:57288
is: C00024
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_15da08de_576d_4a8a_a6b3_56b058c56fbd
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: P37268
is encoded by: hsa:2222
name: FDFT1

metaR r2380
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#

metaR DNDPt8m
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
name: dADP transport via dUDP antiport
is described by: ECO:0000269
reversible: false
is: SBO:0000185

metaM ksi deg4 l
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57737
has only substance units: false
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
is: HMDB00868
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 4
type: Species

metaR ACACt2m
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: Acetoacetate mitochondrial transport via H+ symport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD

http://identifiers.org/biomodels.db/MODEL1310110060#_28093b6b_6fa4_4c76_b728_4944c9c72fc1
name: BCAT1
boundary condition: true
type: Species
is encoded by: hsa:586
initial concentration: NaN
is: P54687
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_b891f434_7d81_4937_928b_281e275944f1
constant: false
initial amount: NaN
type: Species
is: SBO:0000297
has only substance units: false
initial concentration: NaN
boundary condition: true
name: NME1:NME2
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110060#_d7a52035_b481_4d89_8f22_d27bdd928ce5
is encoded by: hsa:54995
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9NWU1
boundary condition: true
name: OXSM

http://identifiers.org/biomodels.db/MODEL1310110060#_e580dac8_f650_4283_8a44_339fdeb8292f
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: P09622
boundary condition: true
type: Species
initial concentration: NaN
name: DLD
is encoded by: hsa:1738

metaM coa x
type: Species
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
constant: false
initial amount: NaN
is: HMDB01423
is: SBO:0000247
is: C00010
is: CHEBI:57287
has only substance units: false
initial concentration: 1.0

metaR DNDPt38m
reversible: false
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
name: dUTP transport via dUDP antiport

metaM nad c
is: http://identifiers.org/pubchem.compound/3305
constant: false
name: Nicotinamide adenine dinucleotide
is: C00003
is: HMDB00902
is: SBO:0000247
type: Species
is: CHEBI:57540
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_6672fe23_848c_450e_a190_e90a4a4428c6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: GPX5
constant: false
is encoded by: hsa:2880
has only substance units: false
type: Species
is: O75715

http://identifiers.org/biomodels.db/MODEL1310110060#_15332644_5c47_4e2f_9378_344fb0519a47
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:18
is: P80404
initial concentration: NaN
type: Species
name: ABAT
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_19fb4ac2_323e_4339_a71a_8fc0d205f8c0
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:5152
name: PDE9A
constant: false
has only substance units: false

metaR NDPK6m
modifier: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110060#_2f62c0b6_5762_452c_b6b4_59ebe3f09ca8
constant: false
has only substance units: false
type: Species
boundary condition: true
name: _NM_013421_1_m
is encoded by: hsa:NM 013421
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_6435f6b7_4845_4a18_9fd5_f0b3ae8edb3c
is: Q8IW54
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5138
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: PDE2A
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_85fd3b26_5ce6_4e63_b2ed_d5676bd49e46
name: _728226_1_e
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:728226
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_4b81ab98_26e4_4c90_b7ab_c5eaefc93777
is encoded by: hsa:AI440329
is: SBO:0000252
name: _AI440329_1_r
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_cd201b38_0bc1_4bac_9b3b_452b13fc9e6e
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: P14550
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10327
name: AKR1A1

http://identifiers.org/biomodels.db/MODEL1310110060#_aeb6e6f2_5c9f_4427_b941_e0eed2d4d1e4
is: SBO:0000252
initial amount: NaN
is: Q59EA4
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5337
type: Species
constant: false
boundary condition: true
name: PLD1

metaR F1PGT
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.30
name: fucose-1-phosphate guanylyltransferase
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM ksi deg16 l
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
name: keratan sulfate I, degradation product 16
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01354
constant: false
is: CHEBI:57455
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_3ac9c14d_83bc_4959_9aa8_0f2836bf5abb
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4512
is: Q7GXY8
name: COX1
initial amount: NaN
is: SBO:0000252
type: Species

metaR r2139
is: SBO:0000185
modifier: MODEL1310110060#
reversible: true
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
kinetic law: MODEL1310110060#
type: Reaction

metaM arachdcrn c
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57387
type: Species
initial concentration: 1.0
is: HMDB01322
name: C20:4 carnitine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_a722e994_8c21_40c2_b7ed_2a3fddf7878d
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6818
boundary condition: true
name: SULT1A3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_747f1827_c8be_4636_9b30_6c38948300b0
name: HAL
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: B4E0V8
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:3034

metaR SPODMn
fast: false
name: superoxide dismutase, nuclear
is: SBO:0000176
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000269
reactant: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR

metaR r0377
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74

metaM pap c
is: CHEBI:58343
initial concentration: 1.0
initial amount: NaN
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: HMDB00061
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_721535fd_1863_4b89_b6d7_d85429e7dc92
initial amount: NaN
name: GLUD1
is encoded by: hsa:2746
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: E9KL48

metaM cholcoa c
type: Species
is: SBO:0000247
is: CHEBI:57373
name: choloyl-CoA(4-)
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial concentration: 1.0

metaR r0186
product: MODEL1310110060#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is: SBO:0000176
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110060#

metaM 10fthf6glu e
is: HMDB00972
is: CHEBI:57454
is: SBO:0000247
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: 10-formyltetrahydrofolate-[Glu](6)
initial concentration: 1.0

metaM uri c
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16704
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
name: Uridine
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00296
initial concentration: 1.0
is: C00299

http://identifiers.org/biomodels.db/MODEL1310110060#_63df7672_8d65_40a3_8f83_5fab651ef615
boundary condition: true
initial amount: NaN
is: P54868
is: SBO:0000252
type: Species
name: HMGCS2
has only substance units: false
is encoded by: hsa:3158
initial concentration: NaN
constant: false

metaR CERT1rt
modifier: MODEL1310110060#
reversible: true
name: ceramide transport protein
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

metaR NDPK6n
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear

metaR AG13T3g
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110060#
is: SBO:0000176
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_26f2dbee_a105_4a5d_805b_7473e57556d1
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: Q13825
boundary condition: true
has only substance units: false
is: SBO:0000252
name: AUH
is encoded by: hsa:549

http://identifiers.org/biomodels.db/MODEL1310110060#_1d2524b8_ed02_42ad_8393_a49e96bad11b
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI191472
constant: false
name: _AI191472_1_c
initial amount: NaN
boundary condition: true

metaM CE2418 m
initial amount: NaN
has only substance units: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
boundary condition: false
is: HMDB11123
constant: false
is: CHEBI:28387
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_c85fb9fc_4465_4d4e_bee3_09eddddd5c4b
is encoded by: hsa:10588
name: MTHFS
initial amount: NaN
constant: false
initial concentration: NaN
is: P49914
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaM lnlncgcoa m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
is: CHEBI:57363
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: gamma-linolenoyl-CoA(4-)
is: SBO:0000247
is: HMDB06368
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_7ada784c_f880_4cd8_a476_2323f1afc3d9
is encoded by: hsa:2235
has only substance units: false
is: SBO:0000252
constant: false
name: FECH
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P22830
type: Species

metaM csn c
type: Species
initial amount: NaN
name: cytosine
has only substance units: false
boundary condition: false
is: CHEBI:16040
constant: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial concentration: 1.0
is: HMDB00630
is: SBO:0000247

metaR r2382
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
reversible: false
modifier: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_59cbaa08_ca7a_4d5f_8abb_cb5f263c16d3
type: Species
name: PDE9A
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:5152

metaM nad e
is: HMDB00902
is: SBO:0000247
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial amount: NaN
type: Species
is: CHEBI:57540
name: NAD(1-)
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaR HCO3 CLt
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
type: Reaction
name: bicarbonate transport (Cl-/HCO3- exchange)
product: MODEL1310110060#
is: SBO:0000185
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
reversible: true
is described by: ECO:0000269

metaM xol7aone c
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
initial amount: NaN
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
is: SBO:0000247
is: HMDB01993
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_0bb9f468_5304_4f26_afde_a54624551cb2
boundary condition: true
constant: false
is encoded by: hsa:5052
name: PRDX1
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR UMPK
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: UMP kinase
type: Reaction
fast: false
modifier: MODEL1310110060#
is described by: ECO:0000269

metaM 4ppcys m
is: HMDB01117
constant: false
has only substance units: false
type: Species
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
boundary condition: false
is: SBO:0000247
is: CHEBI:59458
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352

metaR r1630
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM met L e
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial amount: NaN
is: CHEBI:16643
initial concentration: 1.0
is: SBO:0000247
is: HMDB00696
name: L-methionine
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110060#_cc3e78b7_aaf8_4ebb_bf6d_5a9105458ed3
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:50614
initial concentration: NaN
name: GALNT9
boundary condition: true
is: Q9HCQ5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_523036f0_fdee_4d47_8729_04e4974962a7
constant: false
is encoded by: hsa:4708
is: SBO:0000252
initial concentration: NaN
is: H7C5B8
has only substance units: false
boundary condition: true
initial amount: NaN
name: NDUFB2
type: Species

metaR NDPK1
kinetic law: MODEL1310110060#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
reactant: MODEL1310110060#
fast: false
type: Reaction
modifier: MODEL1310110060#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP)
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM hdcea l
constant: false
name: palmitoleate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
is: HMDB03229
is: CHEBI:32372
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_15281005_46bc_4bc1_943f_ce7cee9b8819
name: LDHAL6A
has only substance units: false
constant: false
is: Q6ZMR3
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:160287

metaM gal c
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: C00124
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
name: D-Galactose
boundary condition: false
is: CHEBI:0
is: HMDB00143
is: SBO:0000247

metaM gchola x
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
has only substance units: false
type: Species
boundary condition: false
name: glycocholate
constant: false
is: SBO:0000247
is: CHEBI:58235
initial concentration: 1.0
is: HMDB00138

http://identifiers.org/biomodels.db/MODEL1310110060#_1eaee6e3_a1c1_4e42_83be_1de00dcdd7e3
has part: P07327
is encoded by: hsa:124
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ADH1A:ADH1B
type: Species
is: SBO:0000297
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_e1f911fb_186a_4cec_8843_ffde7b2b0c15
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: _BE966236_1_c
boundary condition: true
is encoded by: hsa:BE966236

metaR q10tm
product: MODEL1310110060#
name: transport of ubiquinone into mitochondria
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110060#

metaM man6p c
initial amount: NaN
is: SBO:0000247
name: D-Mannose 6-phosphate
is: HMDB01078
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:17369
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
has only substance units: false
boundary condition: false

metaR XYLtly
fast: false
reversible: false
name: Xylose efflux from lysosome
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110060#

metaM 34dhoxmand c
name: 3,4-Dihydroxymandelate
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01866
is: CHEBI:27637
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_ff8985d4_7c1e_4b67_88cc_162c4442bb0c
is encoded by: hsa:4707
boundary condition: true
name: NDUFB1
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: O75438

http://identifiers.org/biomodels.db/MODEL1310110060#_5076008c_6b51_48f3_9938_51800ca69e53
is: SBO:0000252
initial concentration: NaN
name: MAN2A1
boundary condition: true
constant: false
initial amount: NaN
is: Q16706
type: Species
has only substance units: false
is encoded by: hsa:4124

http://identifiers.org/biomodels.db/MODEL1310110060#_f1d017e5_115d_4ca1_a309_e8e98a3b437e
name: TM7SF2
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:7108
boundary condition: true
has only substance units: false
is: O76062
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_0d8df8c7_a127_40b4_973b_66b3a13dc42d
name: SLC25A1
initial concentration: NaN
is: SBO:0000252
is: D9HTE9
boundary condition: true
is encoded by: hsa:6576
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR r1527
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.1
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_44114d04_8a5a_4d2e_9be9_bfeab39fe60f
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:386757
type: Species
name: SLC6A10P
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_a3295d05_0a52_4fdc_850a_4f4e45bf7699
type: Species
boundary condition: true
is: F5H066
constant: false
initial concentration: NaN
name: SLC12A4
is: SBO:0000252
is encoded by: hsa:6560
has only substance units: false
initial amount: NaN

metaR S6T13g
modifier: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_ca4ed9aa_a46f_4a52_bcdb_e0a081d0f4db
boundary condition: true
name: GCH1
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: Q8IZH9
constant: false
is encoded by: hsa:2643
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_fcc3374c_bc20_4ae9_bc32_c5e346c37f4e
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5332
name: PLCB4
is: Q15147
constant: false

metaM pro L c
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: L-proline
is: CHEBI:17203
initial concentration: 1.0
is: SBO:0000247
is: HMDB00162
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

http://identifiers.org/biomodels.db/MODEL1310110060#_66eb4536_b4fc_4454_a2fb_c312fe70907e
initial concentration: NaN
is encoded by: hsa:3945
initial amount: NaN
boundary condition: true
type: Species
is: P07195
constant: false
has only substance units: false
name: LDHB
is: SBO:0000252

metaM dhdascb e
initial amount: NaN
type: Species
is: HMDB01264
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial concentration: 1.0
boundary condition: false
is: CHEBI:58070
name: dehydroascorbide(1-)
has only substance units: false
constant: false

metaM ala D c
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB01310
is: CHEBI:15570
name: D-alanine
constant: false
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false

metaM 4ppcys c
initial amount: NaN
is: CHEBI:59458
constant: false
is: C04352
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
is: HMDB01117
is: SBO:0000247
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

metaR G5SADrm
fast: false
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaR r2200
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110060#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110060#

metaM ppa e
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
name: propionate
is: HMDB00237
is: CHEBI:17272
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

metaM nad x
has only substance units: false
initial concentration: 1.0
is: C00003
is: http://identifiers.org/pubchem.compound/3305
type: Species
is: SBO:0000247
is: CHEBI:57540
boundary condition: false
is: HMDB00902
initial amount: NaN
constant: false
name: Nicotinamide adenine dinucleotide

metaR B MANNASEly
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
reactant: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
name: beta-mannosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.25
product: MODEL1310110060#
reversible: false
is described by: ECO:0000000

metaR P5CR
reversible: false
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
kinetic law: MODEL1310110060#
name: pyrroline-5-carboxylate reductase
is described by: ECO:0000134
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_14c095eb_cc7e_4cc1_ba2c_931bf0c2870d
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: ALDH9A1
is: SBO:0000252
is: P49189
has only substance units: false
is encoded by: hsa:223
initial amount: NaN

metaR MMMm
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.4.99.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
modifier: MODEL1310110060#
name: methylmalonyl-CoA mutase
product: MODEL1310110060#

metaR APOCF
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false
kinetic law: MODEL1310110060#
name: Apocarboxylase formation
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110060#

metaR r1147
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110060#
reversible: true
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185

metaM HC02187 c
type: Species
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
constant: false
is: CHEBI:28774
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: reverse-triiodthyronine

metaR RE1519M
modifier: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1519
is: SBO:0000176
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_02c38e3a_f2a0_4345_9fe3_f61ecf2a180b
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
name: _HG2846_HT2983_1_c
type: Species
has only substance units: false

metaM adn c
is: SBO:0000247
initial amount: NaN
is: C00212
constant: false
type: Species
is: HMDB00050
name: Adenosine
boundary condition: false
is: CHEBI:16335
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212

http://identifiers.org/biomodels.db/MODEL1310110060#_7f064c8b_3152_40d5_b22d_852b2b888be2
boundary condition: true
initial concentration: NaN
constant: false
name: SLC16A2
is encoded by: hsa:6567
is: P36021
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_c9118865_977e_4410_ad20_b8dfb30a805f
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:8879
name: SGPL1
is: O95470
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_0e4fe479_2f38_4ad9_a468_3beb0066d891
initial amount: NaN
constant: false
is encoded by: hsa:AI373818
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: _AI373818_1_m
has only substance units: false

metaM glygn1 c
type: Species
initial concentration: 1.0
is: HMDB06355
constant: false
is: CHEBI:18268
initial amount: NaN
name: glycogen, structure 1 (glycogenin-11[1,4-Glc])
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02133
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM apoC Lys btn c
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
is: CHEBI:32551
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00182
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: SBO:0000247
type: Species
has only substance units: false

metaR ALDD2xm
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110060#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
reversible: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110060#
fast: false

metaR THBPT4ACAMDASE
modifier: MODEL1310110060#
is described by: ECO:0000269
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
is: SBO:0000176
reactant: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_defb0efa_68c4_4243_af55_59730085c01e
type: Species
name: LHPP
is: SBO:0000252
has only substance units: false
constant: false
is: Q9H008
boundary condition: true
initial amount: NaN
is encoded by: hsa:64077
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_d8cde8c7_434b_421b_9f24_de2837745622
is: SBO:0000252
constant: false
is encoded by: hsa:2591
name: GALNT3
has only substance units: false
boundary condition: true
is: Q14435
initial concentration: NaN
type: Species
initial amount: NaN

metaR CORE6GTg
reversible: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false
product: MODEL1310110060#
type: Reaction
is: SBO:0000176
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus

metaR RE3628M
fast: false
name: RE3628
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaR r0009
reactant: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: Pyrophosphate phosphohydrolase EC:3.6.1.1

metaM HC01223 m
type: Species
is: CHEBI:57340
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR 5ADTSTSTERONESte
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
name: sulfonated testosterone transport
kinetic law: MODEL1310110060#

metaR r1932
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM C05279 m
initial amount: NaN
initial concentration: 1.0
name: trans,cis-Lauro-2,6-dienoyl-CoA
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB11123
has only substance units: false
is: CHEBI:28387
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
type: Species

metaR r1148
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
fast: false
name: Active transport
reversible: true
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_0867228e_7b98_4c7b_a1df_ea48d2a1a73b
name: PDE6D
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: O43924
is encoded by: hsa:5147

metaR DCSPTN1COAtx
is described by: ECO:0000000
name: fatty acid intracellular transport
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110060#_4e55fde7_ddad_4c2f_985a_e9c990cd2382
is encoded by: hsa:80025
initial concentration: NaN
initial amount: NaN
type: Species
name: PANK2
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_c4137661_86ef_42c2_a771_5cc4d8cd22b0
is encoded by: hsa:114805
has only substance units: false
is: SBO:0000252
is: Q8IUC8
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: GALNT13
constant: false

metaR GTHPm
is version of: http://identifiers.org/ec-code/1.11.1.12
name: glutathione peroxidase, mitochondria
fast: false
reversible: true
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.11.1.15
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
modifier: MODEL1310110060#

metaM pro L e
has only substance units: false
is: SBO:0000247
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
boundary condition: false
is: HMDB00162
name: L-proline
type: Species
initial concentration: 1.0
initial amount: NaN

metaR FAOXC204
type: Reaction
fast: false
product: MODEL1310110060#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_619b734a_bd17_4427_ada8_509a6c599885
name: PTS
is: Q03393
is encoded by: hsa:5805
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaR r2202
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110060#
fast: false
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR DMNONCRNt
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
fast: false
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_75e9d7d4_e1ca_4c18_8903_5baece2c286e
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P34896
name: SHMT1
constant: false
is encoded by: hsa:6470
initial amount: NaN

metaR DHPM1
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
kinetic law: MODEL1310110060#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.5.2.2
name: dihydropyrimidinase (5,6-dihydrouracil)
reactant: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_50f7e9e9_5cc4_4e70_bd9c_247c13a137c1
is: P00491
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:4860
name: PNP
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_b39b5806_b023_42ad_baf4_cb849d8234ec
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: RRM1
is encoded by: hsa:6240
is: P23921
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM 35cgmp c
initial amount: NaN
is: HMDB01314
boundary condition: false
is: CHEBI:57746
name: 3',5'-cyclic GMP(1-)
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
initial concentration: 1.0

metaM prpp c
initial amount: NaN
type: Species
is: CHEBI:58017
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial concentration: 1.0
boundary condition: false
is: C00119
is: HMDB00280
constant: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
has only substance units: false

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_7754bc54_af56_4525_8295_75445fedbb90
is encoded by: hsa:1633
name: DCK
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: P27707
type: Species

metaM fad m
constant: false
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
is: HMDB01248
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: C00016
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

http://identifiers.org/biomodels.db/MODEL1310110060#_2ee91838_1a7f_4e6c_b61c_8cb53af249a5
has only substance units: false
is: SBO:0000252
is: O43286
initial concentration: NaN
constant: false
is encoded by: hsa:9334
boundary condition: true
initial amount: NaN
type: Species
name: B4GALT5

metaR PPCOAOm
kinetic law: MODEL1310110060#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110060#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
product: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
is: SBO:0000176

metaR r2201
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

http://identifiers.org/biomodels.db/MODEL1310110060#_116eb458_1db7_40eb_a277_4e532e94cc64
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: P21108
boundary condition: true
name: PRPS1L1
is encoded by: hsa:221823
initial amount: NaN
has only substance units: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR q10h2tc
product: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
name: transport of ubiquinol into cytosol
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110060#
is described by: ECO:0000134

metaR r1866
reversible: false
modifier: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction

metaR GAL3ST12
name: Galactosylceramide sulfotransferase
reactant: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.11
reversible: false
fast: false
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ

metaR r1934
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
reversible: false
modifier: MODEL1310110060#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_cc8f67c9_6da9_450e_9e46_3214d5746b1b
initial concentration: NaN
type: Species
is encoded by: hsa:155184
constant: false
initial amount: NaN
is: Q6PXP3
is: SBO:0000252
has only substance units: false
name: SLC2A7
boundary condition: true

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR RE1533M
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1533
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
modifier: MODEL1310110060#

metaR PSDm hs
is version of: http://identifiers.org/ec-code/4.1.1.65
name: Phosphatidylserine decarboxylase
is: SBO:0000176
modifier: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is described by: ECO:0000269
type: Reaction
reversible: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_4447be06_7b73_4c68_a088_f86698002810
constant: false
is: C9JT23
boundary condition: true
name: NDUFA11
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:126328
initial concentration: NaN
has only substance units: false

metaM dcamp c
is: C03794
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: HMDB00536
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: N6-(1,2-Dicarboxyethyl)-AMP
is: CHEBI:57567

http://identifiers.org/biomodels.db/MODEL1310110060#_875bd744_1262_44ae_98a2_02af854baa58
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1806
is: Q12882
name: DPYD
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaR DOLPMT1 Uer
type: Reaction
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.258
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM cholcoaone x
initial concentration: 1.0
is: HMDB06891
constant: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58507
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)

metaM HC01409 m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
name: Hexanoyl-CoA
is: SBO:0000247
is: CHEBI:27540
boundary condition: false
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270

http://identifiers.org/biomodels.db/MODEL1310110060#_e609f978_75cb_40ce_8e66_7d7d1ae23987
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: Q8TBG4
is encoded by: hsa:64850
has only substance units: false
name: AGXT2L1
is: SBO:0000252
initial amount: NaN

metaR DADAe
type: Reaction
modifier: MODEL1310110060#
name: Deoxyadenosine deaminase, extracellular
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is: SBO:0000176

metaR MEOHt2
is: SBO:0000185
kinetic law: MODEL1310110060#
name: Methanol diffusion
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110060#
reversible: true
is described by: ECO:0000000

metaM prpp e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: HMDB00280
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:58017
initial amount: NaN

metaM dcholcoa x
boundary condition: false
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:28701
name: chenodeoxycholoyl coenzyme a
type: Species
constant: false
is: SBO:0000247

metaR G14T20g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110060#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110060#

metaR HSAT4ly
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false
type: Reaction
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is: SBO:0000185
is described by: ECO:0000000
reversible: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaM 4fumacac c
initial concentration: 1.0
is: CHEBI:18034
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB01268
has only substance units: false
initial amount: NaN
name: 4-fumarylacetoacetate(2-)

metaM HC01401 m
is: CHEBI:27668
constant: false
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

metaM biocyt m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
name: Biocytin
constant: false
is: C05552
is: HMDB03134
type: Species

metaM 5aop m
constant: false
type: Species
is: C00430
boundary condition: false
is: HMDB01149
name: 5-Amino-4-oxopentanoate
is: CHEBI:17549
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430

metaR r1492
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Utilized transport
is described by: ECO:0000000
reversible: false

metaM dhf e
is: HMDB01056
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: dihydrofolate(2-)
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57451

metaM kynate c
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: kynurenate
boundary condition: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
type: Species
is: HMDB00715
is: CHEBI:58454
has only substance units: false

metaM HC00900 c
initial amount: NaN
name: Methylmalonate
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:30860
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170

metaR RE0915E
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
modifier: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
is: SBO:0000176
name: RE0915
kinetic law: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
reactant: MODEL1310110060#

metaR DESAT18 3
is described by: ECO:0000269
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
reversible: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR XOL7AH2tm
is: SBO:0000185
fast: false
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport

metaR NACHEXA21ly
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110060#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110060#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_5904c4c7_e431_4fb5_8896_22f61292d9a4
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _J03866_1_m
constant: false
type: Species
is encoded by: hsa:J03866
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_f6d4f006_b796_4bde_91ba_8571f2286d78
is: E7EPT3
boundary condition: true
name: ALDH7A1
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:501

http://identifiers.org/biomodels.db/MODEL1310110060#_684f8620_1b61_4152_b4c7_9fc9563db15c
is encoded by: hsa:195814
initial amount: NaN
name: SDR16C5
type: Species
initial concentration: NaN
boundary condition: true
is: B3KT84
is: SBO:0000252
has only substance units: false
constant: false

metaR RE2349C
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is: SBO:0000176
name: RE2349
fast: false

metaR S23T4g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
name: beta-galactoside alpha-2,3-sialyltransferase
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
fast: false
product: MODEL1310110060#

metaR PPBNGS
is: SBO:0000176
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110060#
fast: false
reversible: false
name: porphobilinogen synthase
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.24
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000269

metaR G6PDH2rer
is: SBO:0000176
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
reactant: MODEL1310110060#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110060#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_2213bf1a_44a4_49f4_8d78_7fcec9628741
has only substance units: false
name: NDUFAB1
initial amount: NaN
is: O14561
is: SBO:0000252
type: Species
is encoded by: hsa:4706
constant: false
boundary condition: true
initial concentration: NaN

metaR FATP2t
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000185
name: fatty acid electroneutral transport
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
is described by: ECO:0000269
reversible: true

metaR r2420
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110060#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_d908f846_847b_41fd_8fc5_fd6e31e7913b
name: PANK2
is: Q9BZ23
constant: false
has only substance units: false
is encoded by: hsa:80025
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_c5dc4bca_cefd_4df9_bbea_ac37ec38afa1
is encoded by: hsa:2882
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q96SL4
type: Species
name: GPX7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_326d3710_7419_49a4_aac4_01dd4c3039ca
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q16850
name: CYP51A1
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1595

http://identifiers.org/biomodels.db/MODEL1310110060#_84e2d427_08eb_458f_9d82_c51c956bb474
type: Species
is: Q8WZ48
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: CPT1A
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1374

metaM gal e
initial amount: NaN
name: D-Galactose
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:0
type: Species
is: C00124
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0
has only substance units: false

metaM biocyt n
has only substance units: false
is: HMDB03134
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
initial concentration: 1.0
constant: false
is: C05552
is: SBO:0000247
type: Species
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

http://identifiers.org/biomodels.db/MODEL1310110060#_3362f21f_c7e8_4fcf_bf41_a01cf86178b3
is: Q9ULC5
name: ACSL5
initial amount: NaN
is encoded by: hsa:51703
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_bbb87150_2ec9_44e0_85cd_d334b8ee9f6f
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:D29675
constant: false
has only substance units: false
initial concentration: NaN
name: _D29675_1_e

http://identifiers.org/biomodels.db/MODEL1310110060#_4f0b0447_917c_4b86_bb13_440c7b446660
name: AOC2
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:314
boundary condition: true
type: Species
is: O75106

metaM 2mbcoa m
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
boundary condition: false
is: CHEBI:57336
name: 2-methylbutanoyl-CoA(4-)
constant: false
is: HMDB01041
initial concentration: 1.0
is: SBO:0000247

metaM ppa c
type: Species
boundary condition: false
initial amount: NaN
name: propionate
constant: false
has only substance units: false
is: CHEBI:17272
is: HMDB00237
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

metaR NDPK10n
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
product: MODEL1310110060#
fast: false
reversible: true
modifier: MODEL1310110060#
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reactant: MODEL1310110060#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear

http://identifiers.org/biomodels.db/MODEL1310110060#_a2cb5106_e9aa_4126_9754_498412c5926c
name: COX7A2L
boundary condition: true
is: SBO:0000252
constant: false
is: Q6FGA0
initial amount: NaN
has only substance units: false
is encoded by: hsa:9167
type: Species
initial concentration: NaN

metaM m8masn g
initial concentration: 1.0
boundary condition: false
is: C05876
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
type: Species

metaM 4hglusa m
is: SBO:0000247
name: L-4-hydroxyglutamic semialdehyde
is: HMDB06556
constant: false
is: CHEBI:27809
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM HC02187 e
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
initial amount: NaN
name: reverse-triiodthyronine
is: CHEBI:28774
has only substance units: false
constant: false

metaR MANtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
name: mannose efflux from Golgi apparatus
is: SBO:0000185
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
reversible: false

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

metaR PSt3
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
name: phosphatidylserine transport
is: SBO:0000185
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000269
type: Reaction

metaR r1867
product: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6ad3aba1_2b39_4956_867d_6b3eb870aac6
type: Species
is encoded by: hsa:4712
constant: false
name: NDUFB6
is: SBO:0000252
initial amount: NaN
is: Q5VYT2
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_c786c36e_b66e_4b9c_897c_84ab884ded83
is: SBO:0000252
name: NDUFV1
is encoded by: hsa:4723
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: E5KNH5
initial concentration: NaN
boundary condition: true

metaR ADSL1
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
reversible: false
name: adenylosuccinate lyase
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.2.2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110060#_b7d32819_d7bd_468c_bb62_5752408eea8d
constant: false
name: NDUFS3
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: O75489
has only substance units: false
is encoded by: hsa:4722
is: SBO:0000252

metaR DMNONCOACRNCPT1
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false
type: Reaction
name: DMNONCOACRNCPT1
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_7c278865_3db3_40e2_9173_5c3eafca7619
is: Q8IWX5
has only substance units: false
is encoded by: hsa:130367
type: Species
name: SGPP2
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR DURIPP
fast: false
name: deoxyuridine phosphorylase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.4.2.3
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_972cf673_039e_41e6_b050_3ff744a24647
initial amount: NaN
is: Q1LZ56
is encoded by: hsa:206358
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC36A1
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_e69ac4e6_100c_4bed_b3d4_808f3de2b629
constant: false
is: SBO:0000252
is encoded by: hsa:2180
is: P33121
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: ACSL1
has only substance units: false

metaM ksi pre3 g
initial amount: NaN
notes: FORMULA: C93H152N6O67X CHARGE: -1
name: keratan sulfate I biosynthesis, precursor 3
is: HMDB00175
initial concentration: 1.0
constant: false
is: CHEBI:58053
type: Species
is: C00130
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM dhf c
name: 7,8-Dihydrofolate
is: SBO:0000247
is: C00415
is: HMDB01056
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_289a5fa8_84c9_457d_830d_142e54bf4ae1
initial concentration: NaN
is: P47989
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is encoded by: hsa:7498
boundary condition: true
name: XDH
initial amount: NaN

metaM ksi deg15 l
type: Species
boundary condition: false
is: CHEBI:12936
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 15
has only substance units: false
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
initial concentration: 1.0

metaR LPASE
name: lysophospholipase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.5
kinetic law: MODEL1310110060#
reversible: false

metaR SBT Dtde
reversible: true
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
name: D-sorbitol transport, extracellular
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
is: SBO:0000185
type: Reaction
is described by: ECO:0000134

metaM ksi deg39 l
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: HMDB00143
boundary condition: false
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 39
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110060#_bd6d705d_07c6_4d48_95b0_63384f4d0b58
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:7371
name: UCK2
initial concentration: NaN
is: Q9BZX2

metaM ksi pre32 g
boundary condition: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 32
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: CHEBI:28067
initial amount: NaN

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR HMBS
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110060#
is described by: ECO:0000254
name: hydroxymethylbilane synthase
is version of: http://identifiers.org/ec-code/2.5.1.61
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#

metaR H2Oter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
type: Reaction
name: H2O endoplasmic reticulum transport
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#

metaM nadp r
initial concentration: 1.0
has only substance units: false
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
constant: false
is: HMDB00217
is: CHEBI:58349
boundary condition: false
initial amount: NaN
type: Species

metaM HC02208 c
boundary condition: false
is: CHEBI:27696
type: Species
name: prostaglandin-d1
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM CE2420 m
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: HMDB11123
is: SBO:0000247
has only substance units: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
constant: false
is: CHEBI:28387

metaR r1628
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_d807b027_5ff0_4cde_bf51_7d9538d14f58
is: Q9NPB1
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:56953
name: NT5M
is: SBO:0000252
has only substance units: false
constant: false

metaR CHOLESTle
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/3.1.1.13
name: hydrolysis of cholesterol ester by cholesterol esterase
modifier: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176

metaR NCKt
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reactant: MODEL1310110060#
reversible: true
name: Na+/Ca2+-K+ exchange
modifier: MODEL1310110060#

metaR RE1525M
product: MODEL1310110060#
fast: false
is: SBO:0000176
name: RE1525
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM 5adtststerones c
has only substance units: false
type: Species
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
constant: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR MMCDm
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
name: Methylmalonyl-CoA decarboxylase, mitochondrial
product: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/4.1.1.9

metaM m8masn r
boundary condition: false
type: Species
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
constant: false
is: C05876
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR BDMT U
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
product: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.142

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM hs deg9 l
name: heparan sulfate, degradation product 9
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: HMDB06355
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
is: CHEBI:18268
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_919ecad6_bb70_42e9_a755_d55355b961c7
name: PDE4B
initial concentration: NaN
is encoded by: hsa:5142
is: Q5TEK5
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_803d506a_d322_42da_a5f6_b3d46e5e5d52
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q96P26
is encoded by: hsa:93034
initial concentration: NaN
constant: false
name: NT5C1B
type: Species
is: SBO:0000252

metaR G6PDH2r
is: SBO:0000176
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.49 Confidence Level: 0 AUTHORS: NOTES:JLR - a reversible reaction that is otherwise identical to ZWF
reversible: true
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.49
product: MODEL1310110060#
name: glucose 6-phosphate dehydrogenase
reactant: MODEL1310110060#
is described by: ECO:0000000

metaR SPODMx
name: superoxide dismutase, peroxisome
is: SBO:0000176
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
kinetic law: MODEL1310110060#
is described by: ECO:0000269
fast: false
reversible: false

metaM ksii core2 pre10 g
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 10
is: CHEBI:28067
has only substance units: false

metaM digalside hs c
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/8383
boundary condition: false
is: C06126
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
initial concentration: 1.0
name: Digalactosylceramide

metaR OCDCEAtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110060#
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_ca707c6c_ce49_46d5_ab04_1888852f9583
boundary condition: true
is: O75452
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: RDH16
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8608

metaM amp c
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: CHEBI:3322
name: AMP
is: C00020

metaM hdcea c
name: Hexadecenoate (n-C16:1)
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32372
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229

metaR GLYt7 311 r
is: SBO:0000185
type: Reaction
reactant: MODEL1310110060#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
reversible: true
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000006
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
modifier: MODEL1310110060#

metaM trdox c
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191
is: SBO:0000247
name: Oxidized thioredoxin
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: C00343
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_35a81878_c1f2_48df_94e7_e35ce3f558dc
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:55350
name: VNN3

metaM duri c
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
is: CHEBI:16450
initial concentration: 1.0
initial amount: NaN
is: C00526
has only substance units: false
is: HMDB00012
constant: false
name: Deoxyuridine
type: Species
boundary condition: false

metaR r1627
reactant: MODEL1310110060#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110060#

metaR RETt
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Retinol transport via faciliated diffusion

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR CDIPTr
reversible: true
fast: false
name: phosphatidylinositol synthase (Homo sapiens)
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.11
is described by: ECO:0000000
modifier: MODEL1310110060#
product: MODEL1310110060#

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM nad r
constant: false
name: NAD(1-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: HMDB00902
is: CHEBI:57540
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

metaR G14T18g
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110060#
fast: false
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_f1b44e8d_9b11_4ad3_ae3a_bc93b3c7d9fc
is: SBO:0000252
is encoded by: hsa:23517
is: Q3MHC9
name: SKIV2L2
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaM 5adtststerones e
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247
is: HMDB06278
initial amount: NaN

metaR O2ter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
fast: false
name: O2 transport, endoplasmic reticulum
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_a645622a_a337_4e30_953c_e8ce0788f33a
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: PDE9A
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110060#_92def721_363c_4704_8315_203dc75ff1f7
is encoded by: hsa:6817
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: SULT1A1

metaM accoa x
initial concentration: 1.0
is: CHEBI:57288
name: Acetyl-CoA
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: C00024
is: HMDB01206
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_a50c301e_0242_41d1_aefa_52d7de82fee3
name: HADHA
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3030
constant: false
type: Species
is: E9KL44
boundary condition: true
initial amount: NaN

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_5064ddc0_2a03_41e0_8184_0c6cd9372606
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:30061
name: SLC40A1
is: Q9NP59
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_3eeffec9_4876_44de_825c_30743bd1b546
initial amount: NaN
is: P28330
is encoded by: hsa:33
name: ACADL
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaM uppg3 c
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
initial amount: NaN
has only substance units: false
name: Uroporphyrinogen III
boundary condition: false
constant: false
is: HMDB01086
is: C01051
is: CHEBI:57308
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR VLCSp
name: Very-long-chain-fatty-acid-CoA ligase
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: false
modifier: MODEL1310110060#

metaM duri e
has only substance units: false
is: HMDB00012
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
is: CHEBI:16450
constant: false
is: C00526

http://identifiers.org/biomodels.db/MODEL1310110060#_49358262_7eea_48a2_9975_6f8dd9739e90
name: _728226_1_m
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:728226
type: Species
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_27093ffa_ae4b_4fbd_a719_a18b7102f43a
boundary condition: true
initial concentration: NaN
type: Species
name: HSD11B1
is: SBO:0000252
constant: false
is encoded by: hsa:3290
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_c21b3d11_e751_4771_9dae_f43d46892d43
boundary condition: true
initial concentration: NaN
type: Species
name: CRAT
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:1384
initial amount: NaN

metaM ksi pre20 g
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
name: keratan sulfate I biosynthesis, precursor 20
type: Species
constant: false
is: SBO:0000247
is: CHEBI:28067
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM pacald c
name: phenylacetaldehyde
initial concentration: 1.0
is: CHEBI:16424
has only substance units: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: HMDB06236
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_3151b316_78fb_4357_8820_b565772cbb08
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AF080579
initial amount: NaN
is: SBO:0000252
name: _AF080579_1_c
constant: false

metaR XOLDIOLONEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
name: lipid, flip-flop intracellular transport
fast: false
reactant: MODEL1310110060#
reversible: true
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_85bee20b_8310_46d2_866a_b945d07f1af9
initial amount: NaN
boundary condition: true
is encoded by: hsa:5152
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: PDE9A
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_bf102b1a_a61b_47a9_9aa7_3882118b189b
is: P49748
name: ACADVL
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:37

metaR BAAT1x
fast: false
type: Reaction
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: bile acid Coenzyme A: amino acid N-acyltransferase
reversible: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is version of: http://identifiers.org/ec-code/2.3.1.65

http://identifiers.org/biomodels.db/MODEL1310110060#_26b775a3_96cf_43f3_b956_245d288b23fb
initial concentration: NaN
is encoded by: hsa:10449
name: ACAA2
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is: P42765

metaM nh4 c
is: C01342
initial concentration: 1.0
name: Ammonium
initial amount: NaN
is: CHEBI:28938
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00051

metaR r1629
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r0002
reversible: true
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
name: Active transport
fast: false
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_c57f2421_224d_4964_b3f0_68b23fbda7aa
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1103
is: P28329
name: CHAT
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_77fe8469_039a_4818_add4_1fdb77103baa
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8803
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: SUCLA2
is: E5KS60

metaM amp e
name: AMP
constant: false
type: Species
is: HMDB00045
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: C00020
is: CHEBI:456215
initial amount: NaN
is: SBO:0000247

metaM ksi pre36 g
name: keratan sulfate I biosynthesis, precursor 36
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
initial amount: NaN
constant: false
is: CHEBI:28067
initial concentration: 1.0

metaM ksi deg34 l
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:57455
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 34
is: HMDB01354
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
has only substance units: false

metaM biocyt c
is: C05552
is: HMDB03134
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
has only substance units: false
type: Species

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR SERGLNexR
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000304
reversible: true
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110060#
name: L-Serine/Glutamine reversible exchange
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_7a198443_3004_4292_a36c_e525b7de0bb3
initial amount: NaN
type: Species
is: Q9BW60
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:64834
has only substance units: false
name: ELOVL1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_f57ec99e_56cf_49b6_9758_a8034adc096f
is: SBO:0000252
is encoded by: hsa:178
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: AGL

metaR GGH 5THFe
is: SBO:0000176
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (5THF), extracellular
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
modifier: MODEL1310110060#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_16c5c772_2a20_4a80_812b_c524e3f88429
name: NPR2
boundary condition: true
initial amount: NaN
is encoded by: hsa:4882
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_8f1afdd8_77d3_4d2e_af18_5bd2cd3491e9
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:AI697028
has only substance units: false
name: _AI697028_1_m
is: SBO:0000252
boundary condition: true

metaR r1418
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is: SBO:0000176
reversible: true
fast: false

metaM HC02023 r
initial amount: NaN
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: Cholesterol-ester-ol
has only substance units: false
is: CHEBI:46898
type: Species

metaM pail34p hs c
is: CHEBI:57658
type: Species
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR r0539
is version of: http://identifiers.org/ec-code/1.1.1.34
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
kinetic law: MODEL1310110060#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
reactant: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#

metaR r1499
product: MODEL1310110060#
reversible: false
is: SBO:0000185
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
type: Reaction
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
is described by: ECO:0000000

metaM HC01007 m
name: L-Octanoylcarnitine
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:18102
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838

http://identifiers.org/biomodels.db/MODEL1310110060#_88053aa2_cd6a_4084_8d79_230c4741f233
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10723
is: Q9Y666
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: SLC12A7

metaR 3SPYRSP
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM

metaR GCC2cm
name: glycine-cleavage complex (lipoamide), mitochondrial
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110060#

metaM digalside hs g
has only substance units: false
is: C06126
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
name: Digalactosylceramide
is: http://identifiers.org/pubchem.compound/8383
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_306b2f79_8933_48fa_9791_3ae77455f67d
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _BE966236_1_m
is encoded by: hsa:BE966236
constant: false
is: SBO:0000252

metaR SFGTH
is described by: ECO:0000269
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.12
name: S-Formylglutathione hydralase
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_739565dd_52fe_4536_9bb1_8a9c5b187ac7
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1609
initial concentration: NaN
constant: false
name: DGKQ
initial amount: NaN
is: P52824
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_2878cc9a_6e08_443f_ba36_d7cbc3920d3e
type: Species
name: GUSB
constant: false
initial amount: NaN
initial concentration: NaN
is: P08236
is encoded by: hsa:2990
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM ocdcea r
initial amount: NaN
is: HMDB00207
name: octadecenoate (n-C18:1)
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
is: C00712
boundary condition: false
is: SBO:0000247
is: CHEBI:0
has only substance units: false
type: Species

metaM hxan e
is: SBO:0000247
is: HMDB00157
type: Species
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: CHEBI:17368
constant: false
name: hypoxanthine
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM nh4 e
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
initial amount: NaN
is: CHEBI:28938
boundary condition: false
initial concentration: 1.0
name: ammonium
constant: false
type: Species
is: HMDB00051
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_af1c70ce_3921_407f_b293_0cd95d42427b
initial amount: NaN
is encoded by: hsa:314
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: AOC2
boundary condition: true

metaM HC02202 e
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
name: prostaglandin A1(1-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57398
has only substance units: false
constant: false

metaM thr L e
name: L-threonine
constant: false
is: CHEBI:16857
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00167

http://identifiers.org/biomodels.db/MODEL1310110060#_c6a913c5_0831_40ce_81b2_064dba873b1c
initial concentration: NaN
is: O95907
name: SLC16A8
type: Species
is encoded by: hsa:23539
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR r0636
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110060#
reactant: MODEL1310110060#
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137

metaM camp c
initial concentration: 1.0
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
constant: false
boundary condition: false
type: Species
is: CHEBI:58165
is: SBO:0000247
is: HMDB00058
has only substance units: false
name: 3',5'-cyclic AMP(1-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_b5eb8fbe_3230_4f36_8836_0372bf990886
has only substance units: false
is encoded by: hsa:51079
type: Species
initial concentration: NaN
is: Q9P0J0
initial amount: NaN
constant: false
is: SBO:0000252
name: NDUFA13
boundary condition: true

metaR AG13T15g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110060#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_f75c196b_f997_4c2d_a419_6fb6bd863f6d
name: GCSH
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:2653
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P23434

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaM ala D e
is: CHEBI:15570
is: HMDB01310
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: D-alanine
initial amount: NaN
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false

metaR GLCURtly
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is described by: ECO:0000269
name: glucuronate transport into lysososme
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#

metaM ksii core4 deg3 l
type: Species
is: SBO:0000247
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 3
is: CHEBI:12936
has only substance units: false
initial amount: NaN
is: HMDB00143
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_ab4baacf_0b48_499e_ad69_574f0d048a29
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:57282
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: B7Z1R0
name: SLC4A10

metaR FAOXC161802m
type: Reaction
reversible: false
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is described by: ECO:0000269
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#

metaM HC02208 e
is: CHEBI:27696
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR r0870
product: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.72
is: SBO:0000185
is described by: ECO:0000000
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.3.4
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
kinetic law: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/3.6.4.13
reversible: true

metaR GULNter
reactant: MODEL1310110060#
name: L-gulonate endoplasmic reticular export
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110060#
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110060#

metaR r0637
type: Reaction
is described by: ECO:0000000
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
reversible: false
is: SBO:0000176
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM nadp x
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: C00006
is: CHEBI:58349
is: HMDB00217
has only substance units: false

metaR DCSPTN1CPT2
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
is: SBO:0000176
name: carnitine transferase
fast: false
is described by: ECO:0000000
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM strch2 e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0
initial concentration: 1.0
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
constant: false
is: HMDB00122
is: CHEBI:4167
initial amount: NaN
has only substance units: false
type: Species

MODEL1310110060#
species: metaM xol27oh r
species: metaM retinal cis 13 r
species: metaM idour e
species: metaM ppi x
stoichiometry: 0.392525
species: metaM 1pyr5c m
species: metaM dcsptn1crn c
species: metaM pyr c
stoichiometry: 0.153018
species: metaM ksi deg37 l
species: metaM udpg e
species: metaM ksi deg38 l
species: metaM pro L m
species: metaM ksi deg30 l
species: metaM HC01444 e
species: metaM hista e
species: metaM anth e
species: metaM abt e
stoichiometry: 0.545544
species: metaM pail34p hs c
boundary condition: true
species: metaM ksi deg22 l
species: metaM 2oxoadp m
species: metaM s7p c
species: metaM 5htrp c
species: metaM h2o2 c
species: metaM zymstnl r
species: metaM fol e
stoichiometry: 0.154463
species: metaM fadh2 m
species: metaM adp n
species: metaM xol7ah c
species: metaM apoC Lys btn m
species: metaM CE2417 m
species: metaM 2mop m
species: metaM gdp n
species: metaM lnlncg c
species: metaM h2o2 m
species: metaM accoa m
species: metaM HC00319 c
species: metaM udp l
species: metaM ksi deg27 l
species: metaM ksi pre7 g
species: metaM pheme m
species: metaM xol7aone m
species: metaM ncam e
species: metaM cl c
species: metaM ump c
species: metaM pmtcoa r
species: metaM pnto R c
species: metaM CE5119 m
species: metaM ala B e
species: metaM pyr m
species: metaM cys L c
species: metaM hs deg22 l
species: metaM ksi pre27 g
species: metaM HC01407 m
species: metaM 4nphsf e
species: metaM naglc2p U c
species: metaM hs deg8 l
species: metaM pap g
species: metaM ksi deg8 l
species: metaM hexdicoa x
species: metaM ksi pre18 g
species: metaM nrpphrsf c
stoichiometry: 0.009898
species: metaM ksi pre10 g
species: metaM spc hs e
species: metaM digalsgalside hs c
species: metaM gthrd e
species: metaM paps g
species: metaM adprbp e
species: metaM xoltriol m
species: metaM trdrd c
species: metaM ksii core4 deg3 l
species: metaM digalside hs c
species: metaM fe2 c
species: metaM dgtp n
species: metaM 2mpdhl m
species: metaM 5aop c

metaR r1497
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
is: SBO:0000185
fast: false
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_3661add2_a8b0_44ff_9bfd_46bbd9c8b324
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
is: P47895
name: ALDH1A3
is encoded by: hsa:220

http://identifiers.org/biomodels.db/MODEL1310110060#_9eea4f0b_d94c_44f7_a8e8_41e43e68ff33
type: Species
initial concentration: NaN
constant: false
name: _AI640625_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI640625

metaR RE3245C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
name: RE3245

metaM sphs1p r
boundary condition: false
is: SBO:0000247
name: sphingosine 1-phosphate(1-)
initial amount: NaN
is: HMDB00277
constant: false
has only substance units: false
is: CHEBI:60119
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0

metaR ICDHy
modifier: MODEL1310110060#
reversible: false
kinetic law: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
type: Reaction
name: isocitrate dehydrogenase (NADP)
fast: false
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.42

metaR APOC LYS BTNPm
fast: false
reversible: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
name: proteolysis of apoC-Lys-btn, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110060#

metaR RE2541E
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
name: RE2541
is: SBO:0000176
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_99ffa25b_7c89_4b8a_9bc8_0633d3848c4d
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:9498
boundary condition: true
name: SLC4A8
initial amount: NaN
is: E7EML0
constant: false
initial concentration: NaN

metaM HC02202 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
name: prostaglandin A1(1-)
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: CHEBI:57398
initial amount: NaN

metaM adn e
is: HMDB00050
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00212
initial amount: NaN
has only substance units: false
is: CHEBI:16335
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false
type: Species

metaM 13 cis retn r
name: 13-cis-retinoate
is: HMDB06219
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: D00348
type: Species
is: http://identifiers.org/pubchem.compound/7847414
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952

http://identifiers.org/biomodels.db/MODEL1310110060#_126378ba_c1bb_4cab_959d_0fa7e3748c9c
type: Species
is encoded by: hsa:1593
constant: false
initial concentration: NaN
name: CYP27A1
boundary condition: true
is: Q02318
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_7043dde1_af52_442f_87cc_8336fdf0547a
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _AA526438_1_m
is encoded by: hsa:AA526438
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR r0638
reversible: true
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.1.2
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaR 3SALATAi
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
modifier: MODEL1310110060#
is described by: ECO:0000304
name: 3-sulfino-alanine transaminase (irreversible)
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM dcholcoa r
is: CHEBI:28701
constant: false
boundary condition: false
name: chenodeoxycholoyl coenzyme a
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
initial amount: NaN
is: HMDB06292
initial concentration: 1.0
is: SBO:0000247

metaR DCSPTN1CPT1
fast: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176
reversible: false
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_eaaf3557_3e51_490d_a689_8e7f0556ff8f
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: SLC4A3
constant: false
is encoded by: hsa:6508
boundary condition: true

metaR GHMT2rm
kinetic law: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176
is described by: ECO:0000269
name: glycine hydroxymethyltransferase, reversible, mitochondrial
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
modifier: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
reversible: true
product: MODEL1310110060#

metaM arachdcrn x
initial amount: NaN
name: C20:4 carnitine
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB06523
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:57368
type: Species

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaR r1621
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaR CGLYt3 2
name: Cys-Gly transport in via proton symport
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000304
product: MODEL1310110060#

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_e76943bb_7e8e_49b9_bcde_3a4a16253768
is encoded by: hsa:6487
name: ST3GAL3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true

metaM HC01444 e
name: Galactosylglycerol
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
has only substance units: false
type: Species
is: CHEBI:15754
initial concentration: 1.0

metaR SUCCOAPET
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR S6T7g
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_a2054f48_0f8c_4ab5_b57a_67299e27a5e5
name: FLAD1
initial amount: NaN
has only substance units: false
type: Species
is: Q8NFF5
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:80308

metaM CE4792 m
name: 3-oxo-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12947
type: Species
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaM CE5121 m
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: trans-3-decenoyl-CoA
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: CHEBI:57449

metaR r0170
reactant: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
kinetic law: MODEL1310110060#
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110060#

metaM leuktrC4 c
boundary condition: false
is: CHEBI:57973
is: HMDB01198
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
name: leukotriene C4(2-)
initial concentration: 1.0
type: Species

metaM apoC c
name: Apocarboxlase (no lys residue)
notes: FORMULA: XH CHARGE: 0
constant: false
is: CHEBI:33190
has only substance units: false
boundary condition: false
is: HMDB11111
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r1622
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reversible: true
type: Reaction

metaM retfa c
type: Species
initial amount: NaN
is: HMDB00305
has only substance units: false
is: CHEBI:50211
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
constant: false
initial concentration: 1.0
boundary condition: false
name: fatty acid retinol
is: SBO:0000247

metaM xmp c
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
is: C00655
boundary condition: false
type: Species
is: HMDB01554
initial concentration: 1.0
constant: false
initial amount: NaN
name: Xanthosine 5'-phosphate
is: CHEBI:57464
is: SBO:0000247
has only substance units: false

metaR GLDBRAN
reversible: false
fast: false
reactant: MODEL1310110060#
name: glycogen debranching enzyme
modifier: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (178.4) or (178.5) or (178.1) or (178.3) or (178.2) or (178.6) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.33 Confidence Level: 4 AUTHORS: PMID:1374391 NOTES:lumped reaction, combination of 4-alpha-D-glucanotransferase (2.4.1.25) and amylo-alpha-1,6-glucosidase (3.2.1.33) NCD
is version of: http://identifiers.org/ec-code/2.4.1.25
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM ha deg1 l
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16336
notes: FORMULA: C22H33N2O16 CHARGE: -1
type: Species
constant: false
name: hyaluronan degradation product 1
has only substance units: false

metaM glcur c
has only substance units: false
constant: false
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR BETALDHxm
name: betaine-aldehyde dehydrogenase, mitochondrial
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000176
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_403118a8_5af5_4a21_a38f_e46b9701d06a
name: CHKB
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1120
has only substance units: false
is: Q9Y259

metaR EX nadp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide phosphate exchange
type: Reaction

metaR LDH L
modifier: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
fast: false
type: Reaction
is: SBO:0000176
name: L-lactate dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110060#_a00fccb8_0c99_4a47_8b95_ffbc8148fb73
is encoded by: hsa:R39999
name: _R39999_1_c
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_136ac36d_b7cf_4296_9fca_46edc50b77ba
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:8560
name: DEGS1
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_9ed5709d_6c36_4cbf_877d_ac3e0fdef9d4
has only substance units: false
name: MECR
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51102
initial amount: NaN
is: Q9BV79
type: Species
constant: false

metaM HC00342 c
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false
is: SBO:0000247
name: cis-aconitate(3-)
has only substance units: false
is: CHEBI:16383
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM dgtp n
constant: false
name: dGTP
initial concentration: 1.0
is: HMDB01440
is: C00286
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:16497
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

http://identifiers.org/biomodels.db/MODEL1310110060#_0d5c187e_d8fb_471e_a319_8f3219745244
name: SLC35D2
initial concentration: NaN
type: Species
is: Q76EJ3
is encoded by: hsa:11046
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR S6TASE1ly
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110060#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176

metaM succ m
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00254
constant: false
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
is: C00042
is: CHEBI:30031
name: Succinate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_db631c9a_6329_42a6_b818_842e7aea7128
constant: false
boundary condition: true
name: PYGB
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5834
is: P11216
is: SBO:0000252
initial amount: NaN

metaR PUNP2
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyadenosine)

metaR r2080
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction

metaR NDPK5n
reversible: true
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

metaR r2141
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110060#
reactant: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110060#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_f409a767_8ead_42ce_b457_ab78175e30fc
type: Species
boundary condition: true
constant: false
name: PDE9A
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5152

metaR HEXDICOAACBPx
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR PYNP2r
name: pyrimidine-nucleoside phosphorylase (uracil)
is version of: http://identifiers.org/ec-code/2.4.2.3
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_295ed13d_ad9f_45aa_a0e4_93189e0ba92c
initial concentration: NaN
boundary condition: true
is: O15244
name: SLC22A2
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:6582

metaR 5MTHFt
fast: false
reversible: true
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis

http://identifiers.org/biomodels.db/MODEL1310110060#_64eebeaa_fdab_4867_8e50_db9562e7fbe9
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLC34A2
is: O95436
initial concentration: NaN
is encoded by: hsa:10568
type: Species
is: SBO:0000252

metaR CYTK14n
fast: false
type: Reaction
product: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110060#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,CTP),nuclear

metaR ORNt3m
is described by: ECO:0000269
reactant: MODEL1310110060#
name: ornithine mitochondrial transport via proton antiport
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false

metaM akg x
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: CHEBI:16810
initial concentration: 1.0
name: 2-oxoglutarate(2-)
boundary condition: false

metaM dolglcp U c
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15812
is: SBO:0000247
type: Species
initial amount: NaN

metaR r0173
is version of: http://identifiers.org/ec-code/3.6.1.19
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
reactant: MODEL1310110060#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
modifier: MODEL1310110060#

metaR PUNP1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
fast: false
modifier: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
name: purine-nucleoside phosphorylase (Adenosine)
product: MODEL1310110060#
reactant: MODEL1310110060#

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM dhlpro m
name: Dihydrolipolprotein
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
initial concentration: 1.0
is: CHEBI:16194
type: Species
has only substance units: false

metaM retfa e
initial amount: NaN
name: fatty acid retinol
constant: false
has only substance units: false
is: CHEBI:15963
is: HMDB00508
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species

metaM gthox c
has only substance units: false
initial concentration: 1.0
is: CHEBI:58297
is: C00127
name: Oxidized glutathione
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
boundary condition: false
is: HMDB03337
constant: false
type: Species

metaR SO4tl
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is: SBO:0000185
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
name: Sulfate transport (lysosome)
reversible: true
kinetic law: MODEL1310110060#

metaR r2140
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110060#
reactant: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false

metaR r1620
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#

metaM glcur e
is: CHEBI:15748
boundary condition: false
constant: false
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: D-glucuronate
type: Species
has only substance units: false

metaM HC00695 m
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
initial concentration: 1.0
is: CHEBI:17432
type: Species
initial amount: NaN
name: S-Succinyldihydrolipoamide

metaM 3pg c
is: C00197
constant: false
name: 3-Phospho-D-glycerate
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3497
has only substance units: false
type: Species
is: HMDB00807
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58272

metaR HAtly
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
name: hyaluronan transport, extracellular to lysosome
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
fast: false

metaR NTD10
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
is: SBO:0000176
is described by: ECO:0000254
name: 5'-nucleotidase (XMP)
kinetic law: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
product: MODEL1310110060#

metaM pail hs c
boundary condition: false
constant: false
is: CHEBI:57880
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)

http://identifiers.org/biomodels.db/MODEL1310110060#_8625d8e4_0b83_461c_b9ba_f47648dacbc3
has only substance units: false
type: Species
name: _AL048840_1_c
is encoded by: hsa:AL048840
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM e4p c
is: HMDB01321
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
name: D-Erythrose 4-phosphate
is: CHEBI:16897
boundary condition: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: SBO:0000247
is: C00279
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_2faa082d_1261_470e_a63a_2cbacffc6a6f
is encoded by: hsa:3000
type: Species
is: Q02846
boundary condition: true
constant: false
name: GUCY2D
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_5ba518df_b2b6_4c78_9f4c_6a3926c583c8
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:221823
type: Species
name: PRPS1L1
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_a1ae4b16_e553_4b1c_ab62_ef24abc56138
is encoded by: hsa:11226
boundary condition: true
initial concentration: NaN
is: Q8NCL4
has only substance units: false
initial amount: NaN
name: GALNT6
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_ff2f7134_0e11_4ee5_b890_0e382ccba4fd
initial concentration: NaN
constant: false
has only substance units: false
name: SLC25A16
is: P16260
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:8034

metaR RTOTALFATPc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR r0160
is: SBO:0000176
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.1.3.2
type: Reaction
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
fast: false
reactant: MODEL1310110060#
reversible: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#

metaM lnlccoa c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
name: linoleic coenzyme A
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
type: Species
is: HMDB01064
constant: false
has only substance units: false
initial concentration: 1.0

metaM ptrc e
is: HMDB01414
constant: false
is: CHEBI:326268
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: C00134
name: Putrescine
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: SBO:0000247
boundary condition: false

metaR HEX7
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110060#
name: hexokinase (D-fructose:ATP)
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4

metaR r0236
reversible: true
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
modifier: MODEL1310110060#
product: MODEL1310110060#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#

metaM glac r
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06355
boundary condition: false
is: CHEBI:18268
initial amount: NaN
is: SBO:0000247
constant: false
name: D-glucurono-6,3-lactone

metaM mal L m
constant: false
is: HMDB00156
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)
is: CHEBI:15589
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR r0853
fast: false
type: Reaction
kinetic law: MODEL1310110060#
name: Facilitated diffusion
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: false
product: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:

metaR r1625
reactant: MODEL1310110060#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
modifier: MODEL1310110060#

metaM apoC Lys btn m
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: http://identifiers.org/pubchem.compound/7886
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03134
type: Species
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial amount: NaN
has only substance units: false
is: C05552

metaR r2379
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_2caf1e75_0032_4c50_b33e_e44dbff17438
is encoded by: hsa:51477
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: B3KRT1
name: ISYNA1

http://identifiers.org/biomodels.db/MODEL1310110060#_50f82d1a_744e_4365_86e5_e8aae5e50cf1
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: VNN3
initial amount: NaN
is encoded by: hsa:55350
is: SBO:0000252

metaR HISCAT1
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_51a81c8f_5c44_407e_b80c_88ced944edcc
has only substance units: false
is: P48735
type: Species
is: SBO:0000252
name: IDH2
boundary condition: true
constant: false
is encoded by: hsa:3418
initial amount: NaN
initial concentration: NaN

metaR HGNTOR
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.5
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#

metaR FAOXC12C12OHm
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaM hs deg13 l
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: heparan sulfate, degradation product 13
is: HMDB01352
boundary condition: false
is: CHEBI:17180
has only substance units: false
type: Species

metaR MM5ag
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.113

metaM 3hpp m
boundary condition: false
is: CHEBI:16510
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
has only substance units: false
is: SBO:0000247
type: Species
name: 3-hydroxypropionate
is: HMDB00700

metaR BTNt2
reversible: true
name: Biotin reversible transport via proton symport
is described by: ECO:0000269
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
product: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_6e5a1d78_f151_4c1c_a7c4_21789d4b62f1
type: Species
boundary condition: true
is encoded by: hsa:6487
name: ST3GAL3
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_76948dba_d1e2_44c2_bf05_c7a1eedbc5a2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:8527
constant: false
boundary condition: true
name: DGKD

http://identifiers.org/biomodels.db/MODEL1310110060#_d882a50b_41d4_4d8c_b7a6_8ef9b565029c
initial amount: NaN
has only substance units: false
is encoded by: hsa:570
boundary condition: true
name: BAAT
is: SBO:0000252
is: Q14032
constant: false
type: Species
initial concentration: NaN

metaR UDPGALtg
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
type: Reaction
name: UDP-Gal Golgi transport via CMP antiport
reversible: true
reactant: MODEL1310110060#
is: SBO:0000185
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110060#_bf10dcca_2cbf_41be_9996_0351246a6925
name: NDUFB9
is: SBO:0000252
type: Species
is: Q9Y6M9
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4715

http://identifiers.org/biomodels.db/MODEL1310110060#_7f896a4c_5212_4e60_9c47_50ba481ee24f
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: NDUFA1
constant: false
type: Species
boundary condition: true
is: Q6IBB5
is encoded by: hsa:4694

metaM xol25oh r
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:42977
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
type: Species
is: HMDB06247
initial amount: NaN
name: 25-hydroxycholesterol

metaR H2O2tn
reversible: true
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
is described by: ECO:0000000
is: SBO:0000185
name: hydrogen peroxide nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110060#_85d5f5c4_7de9_402d_818a_59ccc4d59ef2
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: B4GALT1
constant: false
is encoded by: hsa:2683
is: P15291
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_8760318b_75c0_4f8f_99e6_4251fbebb9d0
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SLC22A3
is: Q5SYN6
type: Species
is encoded by: hsa:6581

metaM dmnoncoa x
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
is: HMDB11604
type: Species
name: 4,8 dimethylnonanoyl-CoA
boundary condition: false
constant: false

metaM taur c
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
constant: false
type: Species
is: HMDB00251
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:3544
initial concentration: 1.0
boundary condition: false
name: Taurine

metaR O2t
reversible: true
name: o2 transport (diffusion)
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD

http://identifiers.org/biomodels.db/MODEL1310110060#_0aa60755_1a89_43f0_a4de_f1b66a40f6f0
constant: false
name: NDUFA1
is encoded by: hsa:4694
boundary condition: true
has only substance units: false
is: Q6IBB5
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_49e25d70_5255_40a0_b4b9_9338d941350b
name: NMNAT2
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q9BZQ4
type: Species
is encoded by: hsa:23057
is: SBO:0000252
initial amount: NaN

metaR RE1807C
is: SBO:0000176
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false

metaR r2378
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction

metaR r0653
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaR r1626
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_493cf4bb_f4ec_42fd_8fe3_977dcaa8db51
is encoded by: hsa:2597
is: E7EUT4
constant: false
name: GAPDH
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_70cf2a87_ebd5_46d7_bbd4_daf49d39cf4e
name: OGDH
type: Species
initial amount: NaN
is encoded by: hsa:4967
is: Q02218
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_83e22fe7_a168_4be8_9aa0_e9b24f3d69a6
is: O00330
type: Species
has only substance units: false
constant: false
is encoded by: hsa:8050
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PDHX

http://identifiers.org/biomodels.db/MODEL1310110060#_d5b51f62_7194_4172_a866_e120a9ebda30
constant: false
name: LDHC
initial amount: NaN
is encoded by: hsa:3948
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR r2142
reversible: true
is: SBO:0000185
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_9aa2a4db_ccda_4342_a5ea_29c6a8c4f590
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: SDHA
has only substance units: false
is encoded by: hsa:6389
initial concentration: NaN
is: P31040

metaM udpg c
is: CHEBI:58367
boundary condition: false
constant: false
is: C00029
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
type: Species
has only substance units: false
name: UDPglucose
is: HMDB00286
initial amount: NaN
initial concentration: 1.0

metaR DNDPt24m
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dADP antiport
fast: false

metaR GALASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
product: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110060#
is described by: ECO:0000000
type: Reaction

metaR ADRNt
reactant: MODEL1310110060#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110060#
name: fatty acid transport via diffusion
is described by: ECO:0000000
fast: false

metaM m4mpdol U r
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:37633

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR RE1897C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: RE1897
product: MODEL1310110060#

metaR CYTK4n
reactant: MODEL1310110060#
name: cytidylate kinase (dCMP,GTP),nuclear
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110060#
fast: false
reversible: true
modifier: MODEL1310110060#

metaR r2377
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_ea9f35ca_2f01_4e1e_af4a_da928dc02b00
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: NT5C2
boundary condition: true
is encoded by: hsa:22978
is: P49902
initial amount: NaN
is: SBO:0000252

metaR r1623
reactant: MODEL1310110060#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_a1077738_f1c7_49d7_9359_76192bb05bc5
name: ACOT6
initial amount: NaN
is: Q3I5F7
is encoded by: hsa:641372
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaM CE2838 e
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: C01936
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
type: Species
is: SBO:0000247
name: maltononaose
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_b8d0dda4_5a33_4356_97e6_d4e4dfd3e7b3
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2678
name: GGT1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR ARABR
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000176
name: arabinose reductase
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21

http://identifiers.org/biomodels.db/MODEL1310110060#_4b90d434_96f2_4410_a44e_4dffd6659c33
is encoded by: hsa:3032
is encoded by: hsa:3030
constant: false
has only substance units: false
type: Species
name: HADHA:HADHB
is: SBO:0000297
has part: E9KL44
boundary condition: true
initial amount: NaN
initial concentration: NaN
has part: P55084

metaM leuktrC4 e
initial concentration: 1.0
is: CHEBI:57973
is: HMDB01198
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: leukotriene C4(2-)
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaM dcdp c
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
has only substance units: false
boundary condition: false
name: dCDP
initial concentration: 1.0
is: CHEBI:58593
is: C00705
is: HMDB01245
initial amount: NaN

metaM nh4 n
initial concentration: 1.0
has only substance units: false
is: HMDB00051
is: SBO:0000247
is: CHEBI:28938
type: Species
constant: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
initial amount: NaN
name: ammonium

metaM HC01007 c
type: Species
is: CHEBI:18102
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
name: L-Octanoylcarnitine

metaR FAOXC10C8x
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR H2O2tp
reversible: true
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
name: hydrogen peroxide peroxisomal transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110060#

metaR r2145
reactant: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#

metaR M16NTg
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
reversible: false
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.143
modifier: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_7af0c634_da2a_4548_82cb_4bfcb7bbe54c
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: FOLR1
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2348

metaM taur e
boundary condition: false
constant: false
name: Taurine
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
is: SBO:0000247
initial amount: NaN
is: CHEBI:3544
initial concentration: 1.0
has only substance units: false
is: C00245

metaR r0651
type: Reaction
fast: false
kinetic law: MODEL1310110060#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110060#
reactant: MODEL1310110060#

metaR r1624
type: Reaction
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true

metaR r2376
product: MODEL1310110060#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110060#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110060#

metaR r0531
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: true
reactant: MODEL1310110060#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000

metaM ksii core2 deg1 l
is: CHEBI:57737
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 1
constant: false
is: HMDB00868
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

metaR PI45P5P
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
reversible: false
modifier: MODEL1310110060#
is: SBO:0000176
fast: false

metaM nh4 m
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00051
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28938
type: Species
constant: false
name: Ammonium

http://identifiers.org/biomodels.db/MODEL1310110060#_310d39b0_bde2_403b_a525_b29981e23558
initial concentration: NaN
name: PDE9A
is: SBO:0000252
constant: false
is encoded by: hsa:5152
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

metaM udpg e
constant: false
is: CHEBI:58367
is: SBO:0000247
boundary condition: false
is: HMDB00286
type: Species
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_88affcc7_303c_493d_9492_7f561529ad81
type: Species
is: P09848
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:3938
is: SBO:0000252
name: LCT

metaR r2144
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110060#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110060#
is: SBO:0000185

metaR S2TASE2ly
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction
kinetic law: MODEL1310110060#
name: iduronate-2-sulfatase, lysosomal
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_5a5d8bfb_4340_4d8d_95f4_8a87d96c156f
is: SBO:0000252
initial concentration: NaN
name: CHST3
constant: false
is: Q7LGC8
is encoded by: hsa:9469
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_4f4e17a7_240a_4dda_988a_313c5dddb4ad
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: O95167
is encoded by: hsa:4696
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: NDUFA3

metaM glu5sa m
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB02104
has only substance units: false
constant: false
is: CHEBI:17232
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: C01165
name: L-Glutamate 5-semialdehyde

metaM pmtcrn c
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:17490
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_d627fb42_6bf6_4d65_93c6_da482d6d11f8
name: PPCS
initial amount: NaN
has only substance units: false
is encoded by: hsa:79717
is: SBO:0000252
constant: false
is: Q9HAB8
boundary condition: true
initial concentration: NaN
type: Species

metaR HDDACBP
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM succ c
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30031
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Succinate
type: Species
is: HMDB00254
constant: false

metaR r0178
modifier: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
reactant: MODEL1310110060#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.5.1.21
product: MODEL1310110060#
reversible: true
is described by: ECO:0000000

metaR r2375
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_95e861d2_79a9_40a7_8935_c23e47076223
initial amount: NaN
name: ALG2
is: Q9H553
constant: false
has only substance units: false
is encoded by: hsa:85365
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r0650
type: Reaction
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM fad e
name: Flavin adenine dinucleotide oxidized
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
is: SBO:0000247
is: C00016
is: CHEBI:16238
boundary condition: false
type: Species
has only substance units: false

metaR r2086
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM HC00342 m
constant: false
is: SBO:0000247
name: cis-aconitate(3-)
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false
is: CHEBI:16383
has only substance units: false

metaR r0423
type: Reaction
is described by: ECO:0000000
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110060#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true

metaR PTPATe
fast: false
reactant: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110060#
reversible: true
name: PTPATe

metaM ins e
initial concentration: 1.0
type: Species
constant: false
is: C00294
is: HMDB00195
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Inosine
initial amount: NaN
is: CHEBI:17596
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294

metaM udpgal c
constant: false
is: CHEBI:58439
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00302
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR LDH D
is described by: ECO:0000304
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.2.4
name: D-lactate dehydrogenase
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM ocdca e
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
initial concentration: 1.0
is: HMDB00827
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:25629
name: octadecanoate (n-C18:0)
is: SBO:0000247
has only substance units: false
type: Species

metaR r0179
modifier: MODEL1310110060#
reversible: true
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_18eda8da_3162_4411_8154_781e0339bff3
is: SBO:0000252
constant: false
is: B4DK61
is encoded by: hsa:51
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: ACOX1
initial concentration: NaN

metaM acmana r
is: CHEBI:17122
is: SBO:0000247
is: HMDB01129
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: N-acetyl-D-mannosamine
initial concentration: 1.0
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645

metaR r0963
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is: SBO:0000185
reversible: false
reactant: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
name: Facilitated diffusion
type: Reaction

metaR r2374
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110060#
is described by: ECO:0000000
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_e63b8629_2eb6_426a_8987_1ead3a4f0637
name: SLC34A1
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q7Z725
is encoded by: hsa:6569
type: Species

metaM ksi pre35 g
name: keratan sulfate I biosynthesis, precursor 35
boundary condition: false
initial concentration: 1.0
is: CHEBI:28067
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_a4137227_32eb_4a12_9c08_8f44ff5d113b
is encoded by: hsa:80201
has only substance units: false
is: B3KT70
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: HKDC1
boundary condition: true

metaM bilglcur e
is: CHEBI:57767
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)

metaR r2085
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110060#

metaR r0424
is: SBO:0000176
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
fast: false
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_aecba6c6_7a6a_4b51_8d65_63b19d5b0393
initial concentration: NaN
name: SLC19A3
is: SBO:0000252
is encoded by: hsa:80704
is: Q9BZV2
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR PAFHe
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
name: Platelet-activating factor acetylhydrolase
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.47
fast: false
is described by: ECO:0000269
reversible: false

metaR r2088
is: SBO:0000185
reversible: true
modifier: MODEL1310110060#
fast: false
type: Reaction
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_7dfb4ea8_e766_47c1_bd50_82d6631ef377
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: B2RB13
type: Species
name: ACSL6
constant: false
has only substance units: false
is encoded by: hsa:23305

metaR AKR1D
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.1.3
is: SBO:0000176
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
modifier: MODEL1310110060#
reversible: false
type: Reaction

metaM ocdcea e
is: C00712
name: octadecenoate (n-C18:1)
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_e0887bd7_7b17_47e8_9ebb_e7299257f67c
constant: false
initial concentration: NaN
name: SLC7A8:SLC3A2
is: SBO:0000297
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:23428
has part: Q9UHI5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_fd72efbb_deee_4634_be18_db7194d1c32e
type: Species
name: AGL
is encoded by: hsa:178
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_7558b94f_4231_4d0b_9f41_c40c7b43cd56
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8704
type: Species
constant: false
name: B4GALT2
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM fad c
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
constant: false
initial amount: NaN
is: HMDB01248
is: CHEBI:16238
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00016
type: Species

metaR r2373
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110060#
type: Reaction
fast: false
reactant: MODEL1310110060#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaM lnlccoa m
has only substance units: false
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR r2087
modifier: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000000

metaR RDH2
kinetic law: MODEL1310110060#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
product: MODEL1310110060#
reversible: true
name: retinol dehydrogenase (9-cis,NADH)
is described by: ECO:0000269
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_931c7c8a_5a8d_4fe2_87b7_1c7315807621
type: Species
is encoded by: hsa:3156
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: HMGCR
is: P04035
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f5b8f8a1_39db_4f73_acda_968b64ab88b1
type: Species
name: HLCS
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:3141
initial amount: NaN
is: SBO:0000252
is: P50747
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_bd92b6ec_c4a9_49b1_a8ed_dc3fa592fcd4
constant: false
name: ALG2
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:85365
boundary condition: true
initial amount: NaN

metaM chlstol r
name: 5alpha-cholesta-7,24-dien-3beta-ol
boundary condition: false
is: HMDB06842
is: SBO:0000247
type: Species
is: CHEBI:16290
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
constant: false
initial amount: NaN
initial concentration: 1.0

metaR 4NPHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
name: xenobiotic transport
kinetic law: MODEL1310110060#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110060#
reactant: MODEL1310110060#

metaR ALAGLNexR
modifier: MODEL1310110060#
is described by: ECO:0000304
type: Reaction
name: L-alanine/glutamine reversible exchange
reversible: true
is: SBO:0000185
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110060#

metaR r2372
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_1694886c_462c_4318_9f61_f750a92e8beb
is: Q15125
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: EBP
constant: false
initial concentration: NaN
is encoded by: hsa:10682
has only substance units: false
type: Species

metaM digalsgalside hs g
initial amount: NaN
is: C06127
is: SBO:0000247
has only substance units: false
name: Digalactosylceramidesulfate
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/8384
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
type: Species
initial concentration: 1.0

metaR r2434
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is: SBO:0000185
kinetic law: MODEL1310110060#

metaM HC01602 c
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
boundary condition: false
is: CHEBI:57454
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

metaR GALASE19ly
modifier: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
product: MODEL1310110060#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM 3hbcoa m
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: CHEBI:57316
initial concentration: 1.0
is: HMDB01166
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_59d5adc8_7e19_4e82_a0e5_266461207bf5
type: Species
is encoded by: hsa:51166
initial amount: NaN
is: Q4W5N8
boundary condition: true
has only substance units: false
constant: false
name: AADAT
initial concentration: NaN
is: SBO:0000252

metaM HC02205 e
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
is: CHEBI:28099
constant: false
boundary condition: false
has only substance units: false
name: prostaglandin-b2

http://identifiers.org/biomodels.db/MODEL1310110060#_fbfa55ba_30d3_4078_af23_7211e64da1d4
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7498
name: XDH
is: P47989
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_dfddf388_cab8_4dbd_9ea8_449b00528453
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q92959
is encoded by: hsa:6578
type: Species
initial amount: NaN
name: SLCO2A1

metaR UAG2EMAi
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
is described by: ECO:0000269
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/5.1.3.14
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
reversible: false
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110060#

metaM bilglcur c
boundary condition: false
has only substance units: false
is: CHEBI:57767
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
is: SBO:0000247

metaR DM atp c
is described by: ECO:0000134
reversible: false
is: SBO:0000176
name: DM_atp(c)
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#

metaM ins c
is: CHEBI:17596
constant: false
is: SBO:0000247
boundary condition: false
name: Inosine
is: C00294
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00195

http://identifiers.org/biomodels.db/MODEL1310110060#_c6898966_15d6_4fc0_b3a9_98186096b424
initial concentration: NaN
type: Species
is: P61457
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5092
boundary condition: true
initial amount: NaN
constant: false
name: PCBD1

metaR G6PDH2c
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.49
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:found in rats. HMP shunt reactions are cytosolic. Irreversible reaction, coefficient changed to 3
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
reversible: false
reactant: MODEL1310110060#
name: glucose 6-phosphate dehydrogenase

metaR NAHCO3 HCLt
reversible: true
fast: false
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
modifier: MODEL1310110060#
reactant: MODEL1310110060#
name: bicarbonate transport (HCl/NaHCO3 exchange)
is described by: ECO:0000269
product: MODEL1310110060#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#

metaR PIt8
is: SBO:0000185
modifier: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
type: Reaction
name: phosphate transport in/out via Na+ symporter
is described by: ECO:0000006
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM

metaR r2371
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110060#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM nh4 x
has only substance units: false
name: Ammonium
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00051
is: C01342
is: CHEBI:28938
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaM ocdcea c
name: octadecenoate (n-C18:1)
is: CHEBI:0
initial amount: NaN
is: C00712
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaR NH4tn
product: MODEL1310110060#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
name: ammonia nuclear transport
reversible: true

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR r1599
type: Reaction
reversible: true
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110060#

metaM 7dhchsterol c
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
has only substance units: false
name: cholesta-5,7-dien-3beta-ol
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: CHEBI:17759
boundary condition: false
initial amount: NaN

metaR FE3R2e
product: MODEL1310110060#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110060#
name: Fe(III) reduction (ascorbate)
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_7246afbd_e739_4d9e_9826_244270bf6efd
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7378
name: UPP1
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r2082
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_06c4822e_c349_4bf0_8861_1b727dc53596
type: Species
is: B3KTV4
is: SBO:0000252
initial amount: NaN
name: ADSSL1
initial concentration: NaN
constant: false
is encoded by: hsa:122622
has only substance units: false
boundary condition: true

metaR GLCNACASE2ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_d7c43fab_fd2d_4851_9e5b_89907d4e8d6f
is: Q86XP1
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:160851
boundary condition: true
constant: false
name: DGKH
is: SBO:0000252
has only substance units: false

metaR KYNAKGAT
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.6.1.7
reactant: MODEL1310110060#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110060#
product: MODEL1310110060#
name: L-Kynurenine:2-oxoglutarate aminotransferase
type: Reaction

metaM didp c
is: CHEBI:28823
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
is: HMDB03536
name: dIDP
type: Species
is: SBO:0000247
constant: false

metaM lpchol hs e
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:60479
name: lysophosphatidylcholine
constant: false

metaM dhdascb c
is: HMDB01264
type: Species
is: CHEBI:58070
initial concentration: 1.0
name: dehydroascorbide(1-)
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: SBO:0000247
boundary condition: false

metaR GALASE4ly
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR F6Tg
type: Reaction
name: glycoprotein 6-alpha-L-fucosyltransferase
product: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.68
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false

metaR ACACT7p
type: Reaction
reactant: MODEL1310110060#
reversible: false
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
fast: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_14d9124a_3f8c_4344_b481_3ca84bb75dc4
type: Species
has only substance units: false
is encoded by: hsa:R14373
name: _R14373_1_x
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_6f1eacad_51ea_46f1_9272_2225a4f66ceb
name: _AV713053_1_m
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AV713053
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR G14T3g
reactant: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_59b3a999_c541_4a9f_8a47_8628e272b49f
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4713
name: NDUFB7
is: P17568
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_3e39d8ce_af4b_4242_98d5_c0181e6b4da0
initial amount: NaN
name: ALAD
boundary condition: true
is: SBO:0000252
constant: false
is: Q6ZMU0
is encoded by: hsa:210
has only substance units: false
initial concentration: NaN
type: Species

metaR r1598
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_189e84dd_e2cd_4fd9_bcc1_268f968a6a2b
initial concentration: NaN
is: P09972
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:230
name: ALDOC
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_1961815f_ccbf_4082_88d4_f90c3f20902b
has part: P53597
is: SBO:0000297
name: SUCLG2:SUCLG1
type: Species
constant: false
is encoded by: hsa:8802
initial concentration: NaN
has part: Q96I99
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8801

metaR r2081
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110060#
reversible: true
is: SBO:0000185
modifier: MODEL1310110060#

metaR TRPHYDRO2
product: MODEL1310110060#
modifier: MODEL1310110060#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reactant: MODEL1310110060#
is described by: ECO:0000269
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.16.4

metaM cala c
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
name: N-carbamoyl-beta-alaninate
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00026
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:11892

metaR Uritn
name: uridine transport in nucleus
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000

metaM digalsgalside hs e
is: http://identifiers.org/pubchem.compound/8384
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
has only substance units: false
type: Species
is: C06127
is: SBO:0000247
boundary condition: false
name: Digalactosylceramidesulfate

metaR RE3520E
product: MODEL1310110060#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: RE3520
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
fast: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.11.1.9

metaR PCm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.1
modifier: MODEL1310110060#
reversible: false
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: pyruvate carboxylase
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
fast: false
is described by: ECO:0000269
product: MODEL1310110060#

metaM HC02205 c
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: prostaglandin-b2
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_2128e299_30fd_45a4_9106_386ed2d13be3
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: FOLR1
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2348

metaR SUCCtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
fast: false
name: succinate transporter, peroxisome
is: SBO:0000185
reversible: true
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaR KHte
product: MODEL1310110060#
name: KHte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR GALt1r
is described by: ECO:0000269
fast: false
type: Reaction
name: galactose transport (uniport)
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
is: SBO:0000185

metaM xylu L c
is: SBO:0000247
boundary condition: false
is: HMDB00751
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: CHEBI:17399
name: L-xylulose
constant: false
initial amount: NaN

metaM dsT antigen g
initial amount: NaN
is: SBO:0000247
name: disialyl-T antigen
is: HMDB01440
initial concentration: 1.0
is: CHEBI:16497
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C36H56N3O26X CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110060#_4cfa0e43_debd_40c5_ac11_d2c8c45c6250
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _AI926493_1_m
is: SBO:0000252
is encoded by: hsa:AI926493
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_94deca98_c2ac_4585_b520_bcbd1fcc9a24
has only substance units: false
boundary condition: true
is: P51648
initial amount: NaN
constant: false
is encoded by: hsa:224
is: SBO:0000252
initial concentration: NaN
name: ALDH3A2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_38517186_42da_4f35_9a9c_9a17c644dc8a
boundary condition: true
has only substance units: false
name: NEU1
type: Species
is encoded by: hsa:4758
is: SBO:0000252
is: Q99519
constant: false
initial amount: NaN
initial concentration: NaN

metaM ksi pre25 g
boundary condition: false
initial concentration: 1.0
is: C00130
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 25
constant: false
type: Species
has only substance units: false
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: HMDB00175
initial amount: NaN
is: CHEBI:58053

metaM g1m8mpdol U r
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: CHEBI:59093
is: SBO:0000247
boundary condition: false

metaR LALDO2x
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
reversible: false
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
fast: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF

metaR NACHEX19ly
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000176
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_32878316_637f_4332_9a2f_919f581937ae
type: Species
initial amount: NaN
has only substance units: false
is: Q16718
name: NDUFA5
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4698

http://identifiers.org/biomodels.db/MODEL1310110060#_ddb1f553_ed2f_4602_b26f_388d7eb32e6e
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: Q15274
name: QPRT
type: Species
is encoded by: hsa:23475
has only substance units: false

metaR r2084
modifier: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false

metaR r0968
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
reactant: MODEL1310110060#
type: Reaction

metaR NACHEX21ly
type: Reaction
kinetic law: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110060#

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.36
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.86
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
modifier: MODEL1310110060#
reversible: false
type: Reaction
is: SBO:0000176

metaR PIt7
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269
name: phosphate transport in/out via three Na+ symporter
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
type: Reaction
is: SBO:0000185
reactant: MODEL1310110060#
reversible: true
fast: false

metaR CYSGLTH
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
fast: false
name: Glutathione:cystine oxidoreductase

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR LNLCCRNt
is: SBO:0000185
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000269
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
type: Reaction

metaR FMNAT
is version of: http://identifiers.org/ec-code/2.7.7.2
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
is: SBO:0000176
name: FMN adenylyltransferase
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
fast: false

metaM lpchol hs c
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:60479
name: lysophosphatidylcholine
has only substance units: false
constant: false

metaR SO4CLtex2
modifier: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000304
fast: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
name: sulfate transport via chloride countertransport (2:1)
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110060#
reversible: false

metaR AG13T4g
modifier: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR DURItn
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
name: deoxyuridine transport in nucleus
reversible: true
fast: false
kinetic law: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185

metaR CHOLD2m
type: Reaction
modifier: MODEL1310110060#
reactant: MODEL1310110060#
name: choline dehydrogenase (FAD acceptor), mitochondrial
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.99.1
product: MODEL1310110060#
is described by: ECO:0000269
kinetic law: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:

metaM duri n
is: HMDB00012
is: CHEBI:16450
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
name: 2'-deoxyuridine
has only substance units: false
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_49e01b97_c6af_475b_a03b_160c0586c980
is encoded by: hsa:4967
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: OGDH
is: Q02218
constant: false
type: Species
initial amount: NaN

metaM hexdiac r
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C16H28O4 CHARGE: -2
is: C08260
boundary condition: false
is: HMDB00672
has only substance units: false
name: hexadecanediocacid

metaM ksii core2 pre6 g
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:28067
initial concentration: 1.0
notes: FORMULA: C61H98N5O46SX CHARGE: -2
constant: false
name: keratan sulfate II biosynthesis, precursor 6

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_38f3f09b_f3c0_40f2_9e14_28824a182ad3
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: _U37519_1_e
is encoded by: hsa:U37519
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_92d787e8_26ea_4870_a6bf_363ab070b058
constant: false
is encoded by: hsa:224
is: P51648
name: ALDH3A2
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR r0426
is: SBO:0000176
modifier: MODEL1310110060#
product: MODEL1310110060#
fast: false
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
kinetic law: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.34
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_fe69f09b_bf30_4285_b3b6_e5687c6021df
boundary condition: true
initial amount: NaN
name: GALNT5
is: SBO:0000252
is: A5PKZ1
type: Species
has only substance units: false
is encoded by: hsa:11227
initial concentration: NaN
constant: false

metaR r2083
is described by: ECO:0000000
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM k e
is: SBO:0000247
is: C00238
constant: false
is: CHEBI:29103
type: Species
has only substance units: false
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: potassium

metaR ARACHDCOAtx
reversible: true
name: fatty acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#

metaM ocdca c
is: CHEBI:25629
boundary condition: false
is: HMDB00827
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
type: Species
name: stearate

metaM ksi pre5 g
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:28067
initial concentration: 1.0
type: Species
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 5
notes: FORMULA: C101H164N7O75SX CHARGE: -2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_cd6b2525_5ce9_408f_b06c_16323d518beb
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AA629629_1_m
is encoded by: hsa:AA629629

metaR PPNCL3
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.3.2.5
name: phosphopantothenate-cysteine ligase
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_22dec614_1c36_4924_a2e8_2e9408bbc6ba
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: NDUFB10
is encoded by: hsa:4716
initial amount: NaN
is: A8K761
has only substance units: false

metaM digalsgalside hs c
is: http://identifiers.org/pubchem.compound/8384
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
has only substance units: false
constant: false
name: Digalactosylceramidesulfate
boundary condition: false
type: Species
is: C06127
is: SBO:0000247

metaR GTHOm
name: glutathione oxidoreductase
reversible: false
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.8.1.7
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
modifier: MODEL1310110060#
type: Reaction

metaR r0384
reactant: MODEL1310110060#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
kinetic law: MODEL1310110060#
type: Reaction

metaM 3aib D m
is: C03265
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
type: Species
name: D-3-Amino-isobutanoate
is: HMDB02299
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

metaR S6T12g
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110060#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false

metaR NACHEX27ly
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_c15e267f_7494_4b5a_a6f1_ac70fd0eb19f
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:29880
boundary condition: true
name: ALG5
initial amount: NaN
is: Q9Y673
is: SBO:0000252

metaM HC02213 c
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: prostaglandin-e3
is: CHEBI:28031
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439

http://identifiers.org/biomodels.db/MODEL1310110060#_cafb6412_a090_4c2e_8b54_bb6424eff608
is: SBO:0000252
is: Q93099
type: Species
name: HGD
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3081
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_b79c522a_e917_4b38_abc2_cefbc3544e6a
initial concentration: NaN
is: Q9UBM1
constant: false
name: PEMT
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:10400
type: Species
is: SBO:0000252

metaR r1594
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: true

metaR r1303
is: SBO:0000185
reversible: false
product: MODEL1310110060#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM adrncoa c
initial concentration: 1.0
name: adrenyl coenzyme A
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205480
has only substance units: false
boundary condition: false
constant: false
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_977b868f_7f41_41dd_99c8_66ef06354583
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5152
has only substance units: false
initial concentration: NaN
name: PDE9A

metaR GGH 5DHFe
reversible: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110060#
is: SBO:0000176
fast: false
name: Gamma-glutamyl hydrolase (5DHF), extracellular
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaR 3HKYNAKGAT
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

metaR MM6bg
fast: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR DM anth
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR S6TASE11ly
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
fast: false
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176

metaR r0385
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
product: MODEL1310110060#
reversible: false
fast: false
kinetic law: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_1a063ed0_41d7_48bd_8980_73d3335ea4e0
name: _T83654_1_c
initial amount: NaN
is encoded by: hsa:T83654
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_f051d6c4_442e_45df_84f2_e4cc23eb8c50
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ACAA1
type: Species
has only substance units: false
is: Q96CA6
initial amount: NaN
is encoded by: hsa:30
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_faba1a85_738d_4cf1_b5d0_f4d8330569e4
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1892
initial amount: NaN
is: SBO:0000252
name: ECHS1
type: Species
boundary condition: true
is: P30084
constant: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR PAPStg
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
modifier: MODEL1310110060#
is described by: ECO:0000269
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
name: 3'-Phosphoadenylyl sufate Golgi transport
fast: false

metaR r1595
type: Reaction
kinetic law: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
fast: false

metaM o2s e
is: HMDB02168
is: CHEBI:18421
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide
has only substance units: false
type: Species

metaR BTNt4i
reversible: false
is described by: ECO:0000269
name: Biotin uptake (antiport)
fast: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
type: Reaction
reactant: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185

metaR TYMSFt
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
reversible: false
reactant: MODEL1310110060#
name: Tyramine O-sulfate transport (diffusion)

metaR TALA
name: transaldolase
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000176
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.2.1.2
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_71c97d4a_eb51_498c_ab87_7de31ae536d5
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:43
is: P22303
constant: false
type: Species
boundary condition: true
has only substance units: false
name: ACHE

metaM akg e
is: SBO:0000247
is: CHEBI:16810
name: 2-oxoglutarate(2-)
boundary condition: false
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

metaM tre e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: C01083
is: CHEBI:16551
type: Species
is: HMDB00975
constant: false
boundary condition: false
name: Trehalose
has only substance units: false
initial concentration: 1.0

metaR NADPNe
kinetic law: MODEL1310110060#
name: NADP nucleosidase,extracellular
is version of: http://identifiers.org/ec-code/3.2.2.5
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000269
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.6 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:See EC 3.2.2.5 for NAD nucleosidase
fast: false
reactant: MODEL1310110060#

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_5e511937_922d_4909_8a53_e03120a13aee
is encoded by: hsa:27034
is: SBO:0000252
is: Q6ZWP6
initial amount: NaN
name: ACAD8
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaR GLYCLTtp
name: glycolate transport into peroxisome
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_8bcacdc3_f035_430c_bf97_fc891887d6e9
is: P30613
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:5313
name: PKLR
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR S23T3g
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
product: MODEL1310110060#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.6
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110060#

metaR CHAT
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000269
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
reversible: true
is: SBO:0000176
fast: false
name: Choline O-acetyltransferase

metaM abt c
is: HMDB01851
is: CHEBI:18403
is: SBO:0000247
type: Species
has only substance units: false
name: L-arabinitol
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN

metaR DPCOAPPe
reactant: MODEL1310110060#
is: SBO:0000176
type: Reaction
name: Pyrophasphatase (dephospho-CoA, extracellular)
is described by: ECO:0000134
fast: false
reversible: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110060#

metaR EX bglc LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for beta glucans
type: Reaction

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR r1596
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 44mzym r
name: 14-demethyllanosterol
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
has only substance units: false
type: Species
is: HMDB01286
initial amount: NaN
is: CHEBI:18364

metaM HC02213 e
initial concentration: 1.0
constant: false
is: CHEBI:28031
type: Species
name: prostaglandin-e3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false

metaM gua e
name: guanine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: CHEBI:16235
is: HMDB00132
type: Species
initial amount: NaN

metaR BIOCYTtn
reactant: MODEL1310110060#
type: Reaction
name: biocytin transport, nuclear
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110060#
is: SBO:0000185

metaR LYStm
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
kinetic law: MODEL1310110060#
is: SBO:0000185
name: Lysine mitochondrial transport via ornithine carrier
type: Reaction
modifier: MODEL1310110060#

metaM ksi deg24 l
is: CHEBI:12936
initial concentration: 1.0
type: Species
is: HMDB00143
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 24

metaM cdpdag hs m
initial concentration: 1.0
name: CDP-diacylglycerol(2-)
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58332
has only substance units: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_2eaff919_62b6_487d_9508_12846f23b45c
initial concentration: NaN
name: PDE8A
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110060#_e227758c_84ad_4e25_9ed2_ba532bbb787c
is: C9JC79
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:6342
name: SCP2

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_11fd29ab_414c_4a7a_a2a9_8743ae76fd00
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5238
name: PGM3
initial concentration: NaN
constant: false
boundary condition: true
is: B4DX94

metaR FTCD
modifier: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
fast: false
name: formimidoyltransferase cyclodeaminase
reversible: false
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.1.2.5
product: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_27f2d455_9714_4429_8314_056da6548352
boundary condition: true
type: Species
is encoded by: hsa:121278
initial amount: NaN
is: SBO:0000252
name: TPH2
is: Q8IWU9
constant: false
has only substance units: false
initial concentration: NaN

metaR r1597
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_1feeaa89_0a0c_47dd_85a8_e7d5a29c050b
constant: false
name: PANK1
type: Species
is: Q8TE04
is encoded by: hsa:53354
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_dbafb2bd_9d2f_4213_8d67_a96d724c0b20
type: Species
initial amount: NaN
is: O95497
name: VNN1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8876
initial concentration: NaN
constant: false
boundary condition: true

metaM o2s c
initial concentration: 1.0
is: HMDB02168
is: CHEBI:18421
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_490f72fb_45a3_4d9c_93b1_46d378d27a04
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:644
is: P53004
initial concentration: NaN
initial amount: NaN
name: BLVRA

http://identifiers.org/biomodels.db/MODEL1310110060#_b496e9d4_83fd_404b_8b8b_6d49318f4c2d
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: SLC6A2
initial amount: NaN
is encoded by: hsa:6530
is: Q96KH8

metaR PGDI
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
modifier: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
name: Prostaglandin-H2 D-isomerase [Precursor]
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/5.3.99.2
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176

metaR LYStn
product: MODEL1310110060#
name: L-lysine transport, nuclear
reversible: true
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reactant: MODEL1310110060#

metaR LEUKTRA4t
product: MODEL1310110060#
fast: false
is: SBO:0000185
reversible: true
name: leukotriene A4 transport
kinetic law: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_66aa8029_fb21_438c_af73_a7826c379986
name: SOD1
constant: false
is encoded by: hsa:6647
is: P00441
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_b557f470_e669_4c02_b8cf_fc850f8f2d16
boundary condition: true
constant: false
is encoded by: hsa:2982
initial concentration: NaN
initial amount: NaN
type: Species
is: D6RDW3
is: SBO:0000252
has only substance units: false
name: GUCY1A3

metaM Rtotal2coa c
is: HMDB00095
is: CHEBI:60377
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: R total 2 coenzyme A
is: C00055
is: SBO:0000247
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
has only substance units: false
type: Species

metaR SUCCt2m
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
product: MODEL1310110060#
is described by: ECO:0000269
modifier: MODEL1310110060#
fast: false
name: succinate transport, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction

metaM abt e
is: CHEBI:18403
name: L-arabinitol
has only substance units: false
boundary condition: false
is: HMDB01851
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

metaM dutp n
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: HMDB01191
is: CHEBI:17625
name: dUTP
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
initial amount: NaN

metaR RE1534M
reactant: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1534
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_bc9bb0b3_7fc6_4d6c_b089_ee197ab74f7b
name: AMT
is encoded by: hsa:275
initial amount: NaN
boundary condition: true
is: P48728
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaM hs deg8 l
has only substance units: false
name: heparan sulfate, degradation product 8
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
constant: false
is: CHEBI:16126

metaM dolglcp U r
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
has only substance units: false
constant: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
is: CHEBI:15812
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM gua c
initial amount: NaN
initial concentration: 1.0
constant: false
name: Guanine
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
has only substance units: false
is: CHEBI:16235
boundary condition: false
is: SBO:0000247
is: C00242
type: Species
is: HMDB00132

metaR DNDPt10m
fast: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
name: dADP transport via dCDP antiport
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: false
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#

metaR r1400
kinetic law: MODEL1310110060#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Active transport
reactant: MODEL1310110060#
product: MODEL1310110060#

metaR FAEL204
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
name: fatty-acyl-CoA elongation (n-C20:4CoA)
is: SBO:0000176
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
product: MODEL1310110060#
type: Reaction
fast: false
reversible: false

metaR ME2
reversible: false
modifier: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.40
fast: false
type: Reaction
name: malic enzyme (NADP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_a0fff80f_56eb_4677_b4f2_ebff5f295ea9
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: C9JFZ1
name: SYNJ1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8867

http://identifiers.org/biomodels.db/MODEL1310110060#_21baadb0_a984_49b0_92a3_98579ee8a63d
is encoded by: hsa:5152
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: PDE9A

metaM idp c
has only substance units: false
initial amount: NaN
name: IDP(3-)
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: SBO:0000247
is: HMDB03335
boundary condition: false
is: CHEBI:58280

http://identifiers.org/biomodels.db/MODEL1310110060#_05bd00ce_ed8e_4096_8de2_94ac75884083
type: Species
is encoded by: hsa:48
initial amount: NaN
is: P21399
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: ACO1

http://identifiers.org/biomodels.db/MODEL1310110060#_89e7ad60_3309_4bf0_9596_3818c2ce9b2f
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: LDHC
initial concentration: NaN
is: P07864
has only substance units: false
constant: false
is encoded by: hsa:3948

metaR GGH 7DHFe
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7DHF), extracellular
product: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_0341cda0_2888_4aa6_9519_383c601a94d8
has only substance units: false
constant: false
type: Species
is encoded by: hsa:3032
name: HADHB
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P55084

http://identifiers.org/biomodels.db/MODEL1310110060#_3c1cf674_fa86_4c6c_9281_d16f15be3929
initial concentration: NaN
boundary condition: true
has only substance units: false
is: B1AM93
type: Species
is encoded by: hsa:4702
constant: false
initial amount: NaN
is: SBO:0000252
name: NDUFA8

http://identifiers.org/biomodels.db/MODEL1310110060#_47cdbeb9_edde_43c7_8364_853714438043
has only substance units: false
name: CA3
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:761
initial amount: NaN
is: P07451

metaM orot e
initial amount: NaN
is: HMDB00226
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
type: Species
name: orotate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a5915a12_3e0f_47aa_8e24_a4d11b741f33
is: SBO:0000252
name: SCD
constant: false
type: Species
is: O00767
is encoded by: hsa:6319
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM ala L c
boundary condition: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
initial amount: NaN
name: L-alanine
is: CHEBI:16977
constant: false
is: SBO:0000247
is: HMDB00161
initial concentration: 1.0

metaM accoa c
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
constant: false
type: Species
name: Acetyl-CoA
is: HMDB01206
boundary condition: false
is: C00024
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57288

http://identifiers.org/biomodels.db/MODEL1310110060#_610bb57e_a404_454a_832c_4df7443aecb9
is encoded by: hsa:6319
constant: false
name: SCD
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: O00767

http://identifiers.org/biomodels.db/MODEL1310110060#_e2866f70_4dc9_4081_9c41_b0b9cbb17416
has only substance units: false
type: Species
is encoded by: hsa:AI926493
is: SBO:0000252
name: _AI926493_1_c
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_e20edcd4_8a7c_43f0_bbc1_3aae66d49852
initial concentration: NaN
is encoded by: hsa:2799
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: Q7Z3X3
name: GNS

metaM udpgal g
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00302
is: CHEBI:58439
name: UDP-D-galactose(2-)
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false

metaR MANt1r
is: SBO:0000185
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: mannose transport (uniport)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
type: Reaction
product: MODEL1310110060#
fast: false
reversible: true

metaM Sfglutth c
initial amount: NaN
is: CHEBI:57688
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: HMDB01550
initial concentration: 1.0
constant: false
name: S-formylglutathionate(1-)
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r1590
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_f3191d86_d138_4d90_9143_cd83b46b1f30
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:81031
type: Species
initial amount: NaN
is: O95528
initial concentration: NaN
is: SBO:0000252
name: SLC2A10

metaM oh1 c
constant: false
boundary condition: false
is: SBO:0000247
name: hydroxide ion
is: HMDB01039
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: C01328

http://identifiers.org/biomodels.db/MODEL1310110060#_6a53232f_9d2f_42a9_ad03_fd708e93c315
is encoded by: hsa:AI620219
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: _AI620219_1_m
initial amount: NaN
boundary condition: true

metaM dutp m
constant: false
is: HMDB01191
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: dUTP
type: Species
is: CHEBI:17625
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN

metaM m6masnC g
is: HMDB01166
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C58H97N2O45X CHARGE: 0
has only substance units: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
is: CHEBI:57316

metaM m1mpdol U c
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
constant: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
is: CHEBI:28067

metaR RE2658R
fast: false
is: SBO:0000176
reactant: MODEL1310110060#
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: RE2658
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000

metaR CHSTEROLtrc
name: transport of cholesterol into the cytosol
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
type: Reaction
is: SBO:0000185

metaR r1925
kinetic law: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: false

metaR PHCHGSm
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
product: MODEL1310110060#
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is: SBO:0000176

metaM xol7ah2al c
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB06894
is: CHEBI:27428
type: Species
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: SBO:0000247

metaM dcsptn1crn m
is: HMDB06321
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM dttp e
is: HMDB01342
constant: false
is: CHEBI:37568
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: dTTP(4-)
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_ae38f141_9bbf_431b_97bc_3330a30a49ab
is encoded by: hsa:4830
name: NME1
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

metaR GLBRAN
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.18
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2632.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.18 Confidence Level: 4 AUTHORS: PMID:8463281 NOTES:NCD
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
reactant: MODEL1310110060#
name: 1,4-alpha-glucan branching enzyme (glygn1 -> glygn2)

http://identifiers.org/biomodels.db/MODEL1310110060#_b30a1b08_8908_45a5_8d3a_67f8a92b1fef
is: SBO:0000252
has only substance units: false
is: Q5SPY7
type: Species
boundary condition: true
name: ENTPD2
is encoded by: hsa:954
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_abc740aa_153a_4044_9793_6e170edfdffc
is: O95340
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:9060
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PAPSS2

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR ADSS
is version of: http://identifiers.org/ec-code/6.3.4.4
reactant: MODEL1310110060#
fast: false
is: SBO:0000176
product: MODEL1310110060#
type: Reaction
name: adenylosuccinate synthase
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is described by: ECO:0000134
kinetic law: MODEL1310110060#
reversible: false

metaR MMEm
name: methylmalonyl-CoA epimerase/racemase
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
is described by: ECO:0000269
kinetic law: MODEL1310110060#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.99.1
reversible: true
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176

metaR r0381
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: true
fast: false
type: Reaction

metaR RDH1
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
fast: false
name: retinol dehydrogenase (all-trans)

metaM sphgn c
name: sphinganine(1+)
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00269
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57817
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_db6bc12c_e751_445f_9874_329f1ebf7f1c
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: RPIA
is: P49247
is encoded by: hsa:22934

metaR ADK3
reversible: true
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is described by: ECO:0000269
fast: false
modifier: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
name: adentylate kinase (GTP)
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.3

metaR r1591
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#

metaR GLXtp
product: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
name: glyoxylate transport, peroxisomal

metaM succ x
is: C00042
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:30031
has only substance units: false
is: HMDB00254
constant: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate

http://identifiers.org/biomodels.db/MODEL1310110060#_eedb53a4_5c33_4bd5_ab38_18e94358d144
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: NDUFC1
boundary condition: true
constant: false
has only substance units: false
type: Species
is: O43677
is encoded by: hsa:4717

http://identifiers.org/biomodels.db/MODEL1310110060#_bf0d8516_0d0f_46ae_8cdf_eb8c4fd6ff40
boundary condition: true
is: E9KL42
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:641371
initial concentration: NaN
type: Species
name: ACOT1
constant: false

metaR r1592
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#

metaM akg m
constant: false
is: SBO:0000247
is: HMDB00208
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
is: C00026
type: Species
has only substance units: false
initial concentration: 1.0
name: 2-Oxoglutarate
initial amount: NaN

metaM xol7ah2 c
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
is: HMDB06893

metaR r0973
name: Facilitated diffusion
is: SBO:0000185
type: Reaction
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_f873ea06_4002_41be_8280_9902ccf5079f
has only substance units: false
type: Species
name: DCK
is: P27707
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:1633

metaR FATP1t
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110060#
is: SBO:0000185
modifier: MODEL1310110060#
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ

metaM orot c
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:30839
is: HMDB00226
has only substance units: false
constant: false
name: Orotate
is: C00295
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial concentration: 1.0
is: SBO:0000247

metaM ksi deg18 l
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00143
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
is: CHEBI:12936
initial amount: NaN
name: keratan sulfate I, degradation product 18
has only substance units: false

metaM idp e
constant: false
type: Species
has only substance units: false
name: IDP(3-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_f8a85d2b_48c3_4c7d_9b85_1a822bb7835d
has only substance units: false
constant: false
is encoded by: hsa:145226
is: Q96NR8
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: RDH12
initial concentration: NaN

metaM ksi deg31 l
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
is: HMDB01354
has only substance units: false
name: keratan sulfate I, degradation product 31
constant: false
initial amount: NaN
is: CHEBI:57455
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR ICDHyrm
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Isocitrate dehydrogenase (NADP+)
product: MODEL1310110060#
fast: false
is: SBO:0000176
reversible: true

metaM e4hglu m
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB02273
name: erythro-4-hydroxy-L-glutamate(1-)
constant: false
has only substance units: false
is: CHEBI:6331
boundary condition: false

metaM hs deg14 l
constant: false
name: heparan sulfate, degradation product 14
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
is: CHEBI:16126
is: SBO:0000247

metaR FAOXC16080m
is: SBO:0000176
reversible: false
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110060#
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM glcur r
has only substance units: false
initial concentration: 1.0
name: D-glucuronate
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
boundary condition: false
type: Species

metaM udpgal e
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: HMDB00302
has only substance units: false
name: UDP-D-galactose(2-)
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
boundary condition: false

metaR G14T21g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
fast: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_c265bb9e_4ac4_4d94_b5d1_5008fb1b1120
is encoded by: hsa:374291
name: NDUFS7
has only substance units: false
is: O75251
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM pan4p e
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: Pantetheine 4'-phosphate
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2
has only substance units: false
initial concentration: 1.0
is: C01134
is: CHEBI:47942

http://identifiers.org/biomodels.db/MODEL1310110060#_9e0a0842_9b90_4006_b125_28d1e9844148
is: O43181
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: NDUFS4
is: SBO:0000252
is encoded by: hsa:4724
boundary condition: true

metaR C14STRr
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70
modifier: MODEL1310110060#
name: C-14 sterol reductase
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
product: MODEL1310110060#
is described by: ECO:0000134
type: Reaction

metaR MI14P4P
reactant: MODEL1310110060#
name: inositol-1,4-bisphosphate 4-phosphatase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

metaR r2079
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#

metaM m4mpdol U c
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM HC01406 m
name: 3-Oxooctanoyl-CoA
is: CHEBI:28264
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_e3434788_61d3_40b0_8d2a_006588a9dfa7
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: AK2
is encoded by: hsa:204
boundary condition: true
is: P54819
initial amount: NaN

metaM dgdp c
constant: false
boundary condition: false
name: dGDP
is: C00361
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
is: CHEBI:58595
is: HMDB00960
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r1593
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_ecc4320b_5797_43b3_bb2d_551a68c85e0b
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:257068
name: PLCXD2
type: Species
initial concentration: NaN
initial amount: NaN
is: Q0VAA5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_09be6439_b607_49e5_bc27_d622c471a706
boundary condition: true
is encoded by: hsa:55825
constant: false
initial amount: NaN
name: PECR
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9BY49
has only substance units: false

metaM acmana e
is: CHEBI:17122
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
has only substance units: false
constant: false
boundary condition: false
is: HMDB01129
name: N-acetyl-D-mannosamine
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_0508a884_7009_49a5_aeba_e243120157e6
boundary condition: true
type: Species
constant: false
name: PANK4
is encoded by: hsa:55229
initial concentration: NaN
is: SBO:0000252
is: Q9NVE7
initial amount: NaN
has only substance units: false

metaR MI13PP
reversible: false
is described by: ECO:0000000
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
name: inositol-1,3-bisphosphate 3-phosphatase
kinetic law: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#

metaR TAGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: triacylglycerol transport

metaM glc D r
type: Species
is: HMDB00122
name: D-glucose
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
is: CHEBI:4167
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM mlthf c
is: C00143
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
boundary condition: false
type: Species
is: CHEBI:15636
has only substance units: false
initial amount: NaN
is: HMDB01533
is: SBO:0000247
constant: false
name: 5,10-Methylenetetrahydrofolate

metaM dttp c
is: C00459
is: SBO:0000247
is: HMDB01342
name: dTTP
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
is: CHEBI:37568
constant: false

metaR CDSm
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.41
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
name: phosphatidate cytidylyltransferase

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR ADK1
modifier: MODEL1310110060#
name: adenylate kinase
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110060#
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110060#

metaM ksii core2 deg2 l
constant: false
name: keratan sulfate II (core 2-linked), degradation product 2
is: HMDB00143
initial concentration: 1.0
type: Species
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
has only substance units: false

metaM 4ppan c
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
name: D-4'-Phosphopantothenate
type: Species
initial concentration: 1.0
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: C03492
is: CHEBI:10986
is: HMDB01016
initial amount: NaN

metaM glcur l
is: HMDB00127
is: CHEBI:15748
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaR UAGDP
type: Reaction
name: UDP-N-acetylglucosamine diphosphorylase
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.23
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
modifier: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_376826d3_d34c_46c9_8097_a5f44b12caa7
is encoded by: hsa:125206
name: SLC5A10
is: A0PJK1
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaM ksii core2 deg4 l
is: SBO:0000247
is: HMDB01354
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C58H95N5O43SX CHARGE: -1
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 4
is: CHEBI:57455
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_392e7157_77c5_4bb4_8c53_68ae11f13a57
constant: false
name: ADCY4
has only substance units: false
is encoded by: hsa:196883
initial amount: NaN
type: Species
initial concentration: NaN
is: Q8NFM4
boundary condition: true
is: SBO:0000252

metaM dmnoncoa c
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
name: 4,8 dimethylnonanoyl-CoA
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB11604
is: SBO:0000247

metaM 3pg m
boundary condition: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: SBO:0000247
type: Species
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial amount: NaN
is: HMDB00807
is: CHEBI:58272
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6c8b2ba8_5e9d_407d_86db_79ac795bb79d
name: INPP5B
is: P32019
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:3633
is: SBO:0000252
constant: false
initial concentration: NaN

metaM ksi pre30 g
boundary condition: false
constant: false
is: HMDB00175
is: C00130
type: Species
is: SBO:0000247
is: CHEBI:58053
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 30
has only substance units: false
initial amount: NaN
notes: FORMULA: C219H350N15O184S9X CHARGE: -10

metaR PUNP7
name: purine-nucleoside phosphorylase (Xanthosine)
is: SBO:0000176
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110060#_f880ccc1_511d_41fc_8e01_51b0bbae4803
initial concentration: NaN
name: PYCR1
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:5831
has only substance units: false
is: SBO:0000252
type: Species
is: A6NFM2

metaR GLGNS1
is version of: http://identifiers.org/ec-code/2.4.1.186
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110060#
name: glycogen synthase (ggn -> glygn1)
is version of: http://identifiers.org/ec-code/2.4.1.11
notes: GENE_ASSOCIATION: (8908.1) and (2997.1) or (2998.1) and (2992.1) or (2997.1) and (2992.1) or (8908.1) and (2998.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.11 Confidence Level: 2 AUTHORS: PMID:15238248 NOTES:NCD
reactant: MODEL1310110060#

metaR THFtm
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: true
type: Reaction
kinetic law: MODEL1310110060#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is described by: ECO:0000000

metaR r1619
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110060#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR HISTAtu
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
reversible: true
name: Histamine uniport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f8e7a6fa_0e0b_46de_9f7b_87d1194978c4
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:8898
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: A6NN98
name: MTMR2
constant: false

metaR r1618
reversible: true
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_3af721f3_90e7_4db0_a3fe_1472c0be57d6
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: Q16774
name: GUK1
boundary condition: true
is encoded by: hsa:2987
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_779c9050_2530_44ef_b27d_0175f286e34e
is encoded by: hsa:8813
constant: false
initial amount: NaN
initial concentration: NaN
is: O60762
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: DPM1

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR NACHEX12ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110060#
reversible: false
reactant: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM ksii core2 pre9 g
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 9
initial amount: NaN
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
boundary condition: false
is: CHEBI:28067

metaM dgtp e
is: HMDB01440
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:16497
is: SBO:0000247
has only substance units: false
name: dGTP

metaR RE3556C
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: RE3556
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaM arg L m
is: HMDB00517
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: CHEBI:32682
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM acmana c
boundary condition: false
type: Species
is: HMDB01129
is: CHEBI:17122
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: N-acetyl-D-mannosamine
has only substance units: false
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM hexdiac c
initial concentration: 1.0
is: SBO:0000247
name: hexadecanediocacid
boundary condition: false
initial amount: NaN
is: C08260
notes: FORMULA: C16H28O4 CHARGE: -2
type: Species
constant: false
is: HMDB00672
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_4a7a54ed_6bcf_48c6_afb9_e872e39a2631
initial amount: NaN
is: SBO:0000252
name: _LOC727762_1_m
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:LOC727762

metaR ABUTD
is described by: ECO:0000269
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: Aminobutyraldehyde dehydrogenase
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
kinetic law: MODEL1310110060#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_df5b00ac_a25f_40eb_9435_07641109bce2
type: Species
boundary condition: true
name: DPM3
has only substance units: false
is encoded by: hsa:54344
is: SBO:0000252
is: Q9P2X0
initial concentration: NaN
initial amount: NaN
constant: false

metaR r1617
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#

metaM o2s m
name: Superoxide anion
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: SBO:0000247
type: Species
is: C00704
is: HMDB02168
is: CHEBI:18421
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR MALTSULtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000269
modifier: MODEL1310110060#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110060#
name: Malate:thiosulfate antiport, mitochondrial
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_ca5bbeca_a4ca_4495_bdb7_8dea32982e37
is: SBO:0000252
initial amount: NaN
name: AQP8
has only substance units: false
initial concentration: NaN
is encoded by: hsa:343
is: O94778
boundary condition: true
type: Species
constant: false

metaM core3 g
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16250
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
name: Core 3
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_e38dc2ae_3b8d_4a38_8ef8_b56b1ddcc08d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3635
name: INPP5D
type: Species
has only substance units: false
is: Q92835
is: SBO:0000252
initial amount: NaN
constant: false

metaR ADCim
reversible: false
fast: false
name: Acetoacetate decarboxylation (irreversible), mitochondrial
kinetic law: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_312e7567_12bd_4351_9ccf_eb5431a91abe
initial concentration: NaN
is: Q86YI5
name: DLAT
boundary condition: true
type: Species
is encoded by: hsa:1737
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaR NCCt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6559.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739168,PMID:8528245,PMID:8670281,PMID:8812482 NOTES:NCD
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: Na+-Cl- cotransport

metaR CO2ter
type: Reaction
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110060#
name: CO2 endoplasmic reticular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000

metaM s2l2fn2m2masn g
is: HMDB00868
notes: FORMULA: C90H145N6O65X CHARGE: -2
constant: false
has only substance units: false
is: CHEBI:57737
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: PA6

metaR THYMt
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
modifier: MODEL1310110060#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction
product: MODEL1310110060#
name: thymine reversible transport via facilated diffusion
reversible: true

metaR PTPAT
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.7.3
is: SBO:0000176
modifier: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
type: Reaction
kinetic law: MODEL1310110060#
fast: false
reversible: true

metaR G16MT U
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
fast: false
product: MODEL1310110060#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR AG13T14g
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110060#
reactant: MODEL1310110060#

metaM oh1 e
boundary condition: false
initial concentration: 1.0
name: hydroxide ion
is: C01328
constant: false
notes: FORMULA: HO CHARGE: -1
is: HMDB01039
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_85f165c9_b3e8_4bec_b30b_87ecc16e524e
boundary condition: true
constant: false
name: SLC17A3
is: O00476
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:10786
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_410fe970_2646_4a1c_b910_6f4066c76abf
is: SBO:0000252
constant: false
is encoded by: hsa:55312
has only substance units: false
initial concentration: NaN
is: B2RDZ2
boundary condition: true
type: Species
name: RFK
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_4a8a9d21_8a46_4b34_9f83_cbbf4a84d1b3
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3614
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: IMPDH1
is: C9JV30
constant: false

metaM apoC m
is: CHEBI:32551
notes: FORMULA: XH CHARGE: 0
name: Apocarboxlase (no lys residue)
has only substance units: false
type: Species
boundary condition: false
is: HMDB00182
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR GCCbim
is described by: ECO:0000269
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.4.4.2

metaR FAOXC12C10x
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_94c9d4e0_567e_4f74_95c5_1dc9135a95e9
name: CHAT
initial concentration: NaN
is: SBO:0000252
is: Q6LEN6
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:1103
boundary condition: true

metaM glac c
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB06355
has only substance units: false
name: D-glucurono-6,3-lactone
is: CHEBI:18268
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
boundary condition: false

metaR RE1903R
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110060#
reversible: true
fast: false
is described by: ECO:0000000
name: RE1903
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:

metaM ak2lgchol hs e
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: http://identifiers.org/pubchem.compound/6975
initial amount: NaN
is: C04317

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_441d889e_8e5a_41e2_b811_8faea77e7e7a
is: Q14432
name: PDE3A
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5139
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaR r1616
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_7d3f3e4b_34f6_4bd5_9957_f566cd857401
type: Species
boundary condition: true
is: SBO:0000252
name: PI4KB
initial amount: NaN
is: Q9UBF8
has only substance units: false
constant: false
is encoded by: hsa:5298
initial concentration: NaN

metaR r1926
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110060#
name: Y+LAT2 Utilized transport
reversible: false
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110060#

metaR XOLTRIOLtm
reversible: true
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_04b8a712_aa39_4ed0_bd12_df14ca7000db
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AL050025
is: SBO:0000252
name: _AL050025_1_c
initial amount: NaN
type: Species
boundary condition: true

metaM hs deg4 l
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
type: Species
boundary condition: false
is: CHEBI:16126
initial amount: NaN
name: heparan sulfate, degradation product 4
initial concentration: 1.0

metaM dgtp c
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
is: HMDB01440
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16497
name: dGTP
is: SBO:0000247

metaR MTHFD2
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110060#
name: methylenetetrahydrofolate dehydrogenase (NAD)
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
type: Reaction
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_255b602c_b94f_4e4b_91f0_1590516b9086
type: Species
initial concentration: NaN
is: P09669
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:1345
has only substance units: false
name: COX6C

metaR GLXtm
is: SBO:0000185
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110060#
name: glyoxylate transport, mitochondrial
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_e38153a4_31c7_4e33_bdee_d098538bf485
has only substance units: false
type: Species
name: BCKDHB
is: P21953
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:594
boundary condition: true
initial concentration: NaN

metaM trdrd c
is: C00342
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:15967
type: Species
name: Reduced thioredoxin
is: SBO:0000247
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a9b61723_e7e1_4c8f_bea2_19411484c6f4
initial concentration: NaN
boundary condition: true
is: Q9P2T1
name: GMPR2
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:51292

metaM didp n
constant: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP
boundary condition: false
initial amount: NaN
is: HMDB03536
is: SBO:0000247
type: Species
is: CHEBI:28823
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_af8311a4_3596_4199_9581_a9dccfe460f8
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: ST6GALNAC1
is encoded by: hsa:55808
is: SBO:0000252
is: Q9NSC7
initial concentration: NaN

metaM arachdcrn m
is: CHEBI:57387
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247
initial concentration: 1.0
is: HMDB01322
name: C20:4 carnitine
has only substance units: false

metaR FUMSO4tm
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
name: Fumarate:sulfate antiport, mitochondrial
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110060#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_e7fe29bc_7853_4167_9348_f092d96cf16a
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: SDHC
initial concentration: NaN
is encoded by: hsa:6391
is: Q99643
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_a7843c3e_6a50_4cde_9f05_5c01303f9497
type: Species
constant: false
initial concentration: NaN
name: _LOC374569_1_e
boundary condition: true
has only substance units: false
is encoded by: hsa:LOC374569
is: SBO:0000252
initial amount: NaN

metaR THRGLYexR
kinetic law: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110060#
fast: false
type: Reaction
modifier: MODEL1310110060#
reversible: true
name: L-threonine/glycine reversible exchange
product: MODEL1310110060#

metaM dcsptn1crn c
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial amount: NaN
constant: false
is: HMDB06321
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_f28bf2f5_3b30_408a_93cc_48e4783a9968
is: SBO:0000252
type: Species
name: GALNT10
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55568
boundary condition: true
initial amount: NaN
constant: false

metaM dutp c
is: C00460
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
initial amount: NaN
has only substance units: false
name: dUTP
is: SBO:0000247
is: HMDB01191
type: Species
constant: false

metaM gum e
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
initial concentration: 1.0
is: C08260
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB00672
is: SBO:0000247
name: gums

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR r1615
reactant: MODEL1310110060#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#

metaM mal L c
name: (S)-malate(2-)
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_2b5bafbe_c9b8_4dcc_97d1_e9142a652398
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:50
is: Q99798
initial amount: NaN
has only substance units: false
name: ACO2

metaM s2l2fn2m2masn e
is: C00255
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: HMDB00244
is: CHEBI:3554
name: PA6
boundary condition: false
initial amount: NaN

metaM T antigen g
name: T antigen (core 1)
boundary condition: false
is: CHEBI:22783
initial concentration: 1.0
type: Species
notes: FORMULA: C14H24NO10X CHARGE: 0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_b31436d8_4294_4687_a21e_a131e639e0a7
name: NDUFB3
is: Q6IB80
type: Species
is encoded by: hsa:4709
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_1e00652b_502c_4b2d_beb0_621981f16d15
type: Species
is encoded by: hsa:89869
name: PLCZ1
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: Q86YW0
has only substance units: false
boundary condition: true

metaM ksi deg14 l
constant: false
boundary condition: false
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
has only substance units: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
name: keratan sulfate I, degradation product 14
initial amount: NaN
type: Species
initial concentration: 1.0

metaR L LACt2r
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
name: L-lactate reversible transport via proton symport
modifier: MODEL1310110060#
reversible: true
fast: false
is described by: ECO:0000269
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185

metaM dcdp n
is: HMDB01245
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:58593
constant: false
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
initial amount: NaN
name: dCDP(3-)

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM xol7ah2 m
is: HMDB06893
is: CHEBI:28047
name: 5beta-cholestane-3alpha,7alpha-diol
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR MAL Lte
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
name: Transport of L-malate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110060#
is: SBO:0000185
reversible: true
type: Reaction

metaM arachdcrn r
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: C20:4 carnitine
has only substance units: false
is: CHEBI:57368
is: SBO:0000247
initial amount: NaN
is: HMDB06523

metaM lac L x
name: (S)-lactate
constant: false
type: Species
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
initial amount: NaN
is: HMDB00190
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_923d78a0_3ac7_40a6_8fb9_aebca115adba
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:1351
is: Q53XN1
name: COX8A
type: Species

metaM hs deg20 l
constant: false
name: heparan sulfate, degradation product 20
initial concentration: 1.0
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110060#_03a1a0cb_92b8_4be5_bc74_c661fa86a68e
has part: Q86U05
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000297
name: SLC7A8:SLC3A2
has only substance units: false
is encoded by: hsa:23428
constant: false

metaR LPCOXp
is: SBO:0000176
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.5.3.1
name: L-pipecolate oxidase, peroxisomal
type: Reaction
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_685b4bab_6d89_4100_9dfe_ba2eba69629f
constant: false
boundary condition: true
is encoded by: hsa:8836
name: GGH
has only substance units: false
is: Q92820
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR ARACHCPT1
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reversible: false
name: carnitine transferase
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110060#_0cdc10e7_d2a4_491c_8d12_54549f337be9
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:3295
boundary condition: true
has only substance units: false
is: E9PB82
name: HSD17B4
initial amount: NaN

metaR G14T10g
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is: SBO:0000176
modifier: MODEL1310110060#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_1aeff57b_fe00_474d_90ef_6ef6fba3bf62
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: PDE7A
is encoded by: hsa:5150
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_762680ea_16f3_4121_9e94_0b98918018ee
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51733
boundary condition: true
constant: false
type: Species
name: UPB1
is: B3KNC1
is: SBO:0000252

metaM dcdp m
type: Species
initial concentration: 1.0
is: CHEBI:58593
has only substance units: false
is: HMDB01245
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
constant: false
name: dCDP(3-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_7128115d_d48c_4aa0_883a_c07950ba3a60
initial concentration: NaN
name: ATP10A
is: O60312
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57194
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_4fbabc84_0e9d_423d_99cb_c3f42f71b19b
is encoded by: hsa:50700
initial amount: NaN
is: Q9NYR8
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: RDH8
boundary condition: true
initial concentration: NaN

metaM gcald c
is: HMDB03344
is: CHEBI:17071
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
initial amount: NaN
name: glycolaldehyde

http://identifiers.org/biomodels.db/MODEL1310110060#_5868c57d_44d0_403c_bc06_620bea33d3c9
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: A8K3L7
is encoded by: hsa:10423
name: CDIPT

metaR BDHm
reversible: true
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000269
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.30
product: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
fast: false
type: Reaction

metaM mal L e
initial concentration: 1.0
initial amount: NaN
constant: false
name: (S)-malate(2-)
is: HMDB00156
has only substance units: false
boundary condition: false
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_0c6c86d6_3f43_48a2_9a3e_dee4f016aee8
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9963
is: Q9UHI7
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: SLC23A1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_ea8c57ed_b01e_483e_8633_d4554cf6a3d3
initial amount: NaN
is encoded by: hsa:728637
constant: false
type: Species
name: _728637_1_c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_5eb96bab_9fd1_4230_a486_49af959322b4
name: MTHFD2L
is: Q9H903
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:441024
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR ARACHCPT2
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
kinetic law: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
type: Reaction
name: carnitine transferase
product: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#

metaR PUNP4
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110060#
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
type: Reaction
reactant: MODEL1310110060#
name: purine-nucleoside phosphorylase (Deoxyguanosine)

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR NADNe
kinetic law: MODEL1310110060#
name: NAD nucleosidase,extracellular
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.2.5
reactant: MODEL1310110060#
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: false
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_b1427aab_4557_428a_b28d_09d7473f49f5
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: P54802
name: NAGLU
is encoded by: hsa:4669
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR G14T17g
is described by: ECO:0000000
modifier: MODEL1310110060#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110060#_6790812d_a243_4142_b16b_077a7bcfe4f5
initial concentration: NaN
is: Q9Y2Q0
has only substance units: false
initial amount: NaN
is encoded by: hsa:10396
type: Species
constant: false
name: ATP8A1
boundary condition: true
is: SBO:0000252

metaM idp n
is: HMDB03335
has only substance units: false
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
is: CHEBI:58280
is: SBO:0000247
name: IDP(3-)
initial amount: NaN
constant: false
type: Species

metaR CSND
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: false
name: Cytosine deaminase
type: Reaction
product: MODEL1310110060#

metaR r1487
reversible: true
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
name: EC:6.2.1.3
is: SBO:0000176

metaR ASNPHELAT2tc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM pmtcrn r
constant: false
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
is: CHEBI:17490
type: Species
initial amount: NaN
name: L-palmitoylcarnitine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR r0647
reversible: true
reactant: MODEL1310110060#
name: Spontaneous reaction
is: SBO:0000176
kinetic law: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_43a500f0_7529_42c5_9bf6_fc8bc50aee4c
is encoded by: hsa:7941
name: PLA2G7
is: Q13093
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR ADSK
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110060#
reversible: false
product: MODEL1310110060#
type: Reaction
is: SBO:0000176
name: adenylyl-sulfate kinase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110060#
fast: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_9d5ea83b_8406_4bf9_a596_b97b61354627
has only substance units: false
name: ECI2
initial amount: NaN
is encoded by: hsa:10455
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: O75521
is: SBO:0000252

metaR PUNP5
is: SBO:0000176
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Inosine)
reactant: MODEL1310110060#
fast: false

metaR NAGA2ly
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reversible: false
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
name: N-acetylgalactosaminidase, alpha-
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.49

metaR LNLNCGt
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110060#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110060#

metaM o2s n
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
constant: false
name: superoxide
is: HMDB02168

metaR SPODM
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
modifier: MODEL1310110060#
name: superoxide dismutase
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false
reversible: false
kinetic law: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is: SBO:0000176

metaR PUNP6
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#
modifier: MODEL1310110060#
name: purine-nucleoside phosphorylase (Deoxyinosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_08b4fdbe_65c5_44c3_a6db_2ebb0118b019
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:219
is: P30837
type: Species
initial concentration: NaN
boundary condition: true
name: ALDH1B1

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaM akg c
is: C00026
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00208
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
name: 2-Oxoglutarate

metaR BTNPLm
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial

metaR THYMDt1
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
name: thymd transport
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
reversible: false
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:9693094 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110060#_61c62a2f_be82_4bec_83ea_232c5c972258
name: HK2
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:3099
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P52789

metaR r1304
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
name: Vesicular transport
fast: false
kinetic law: MODEL1310110060#
reversible: false
is: SBO:0000185

metaR KSII CORE2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
name: keratan sulfate II (core2) transport, golgi to extracellular

metaR CYTDK2m
fast: false
name: cytidine kinase (ATP), mitochondrial
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110060#_73756aa7_13f3_47d0_999d_b7fe1a4a6617
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: NDUFV2
initial concentration: NaN
is: P19404
boundary condition: true
constant: false
is encoded by: hsa:4729

metaM pan4p m
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: SBO:0000247
is: HMDB01416
name: pantetheine 4'-phosphate(2-)
has only substance units: false

metaR S6TASE22ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
reversible: true
type: Reaction
name: galactose-6-sulfate sulfatase, lysosomal
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR It
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000185
name: Iodide uniport
reactant: MODEL1310110060#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD

metaR MALTt1r
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
name: maltose transport (uniport)
reactant: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110060#_d4d0ce5b_81de_4719_9c48_71eca012d291
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ACAD10
is encoded by: hsa:80724
is: G3XAJ0
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR ARACHDt2
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110060#_32078156_2cec_469f_8791_8f8b902c3484
constant: false
is: P28907
name: CD38
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:952
initial concentration: NaN
type: Species
is: SBO:0000252

metaM h2o n
boundary condition: false
is: CHEBI:15377
has only substance units: false
initial concentration: 1.0
name: water
is: SBO:0000247
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
initial amount: NaN
is: HMDB02111

metaM pi g
constant: false
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: CHEBI:43474
initial concentration: 1.0
is: HMDB00973
name: hydrogenphosphate
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_9f6fd7b7_c919_4b10_b501_1cf048bc1e71
is encoded by: hsa:100
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ADA
initial amount: NaN
constant: false
type: Species
is: P00813
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_2f9f6e4b_4cb1_43a2_96e6_6dbb3bfeb5fe
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:1719
initial concentration: NaN
is: P00374
constant: false
initial amount: NaN
has only substance units: false
name: DHFR

metaR PROSTGD2t
modifier: MODEL1310110060#
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110060#
is: SBO:0000185
reversible: true
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000269
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_06ab9f9b_49b2_4347_8e39_181257386ba5
is: SBO:0000252
is encoded by: hsa:122481
initial amount: NaN
name: AK7
type: Species
initial concentration: NaN
is: Q96M32
has only substance units: false
constant: false
boundary condition: true

metaM hco3 e
constant: false
is: C00288
initial amount: NaN
is: HMDB00595
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Bicarbonate

metaR r2365
product: MODEL1310110060#
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110060#

metaR r1611
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_dff47cdb_d352_4bd3_979d_698c4d7e3076
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q99643
has only substance units: false
name: SDHC
type: Species
initial amount: NaN
is encoded by: hsa:6391

metaM citr L e
boundary condition: false
is: HMDB00904
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16349
constant: false
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: citr_L[e]

metaR DOLP Uter
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
kinetic law: MODEL1310110060#
name: dolichol phosphate flippase (uterus)
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaM lnlc e
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: CHEBI:30245
boundary condition: false
name: linoleate
is: HMDB00673
constant: false

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaM drib c
type: Species
is: CHEBI:28816
initial concentration: 1.0
boundary condition: false
is: HMDB03224
constant: false
name: 2-deoxy-D-ribose
is: SBO:0000247
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
initial amount: NaN
has only substance units: false

metaR GLNATB0tc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Glutamine into the intestinal cells by ATB0 transporter
type: Reaction

metaM cdp e
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:58069
initial amount: NaN
is: HMDB01546
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)

metaR LINOFATPtc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM ksii core4 pre3 g
notes: FORMULA: C55H89N5O38X CHARGE: -1
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 3
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: C00130
is: HMDB00175

metaR IMPD
name: IMP dehydrogenase
product: MODEL1310110060#
modifier: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.205
type: Reaction
reversible: false
kinetic law: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110060#_a9fe0c21_170c_4924_aa92_7035411e9da9
is encoded by: hsa:AI631997
is: SBO:0000252
type: Species
name: _AI631997_1_m
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM h2o m
is: C00001
constant: false
initial concentration: 1.0
type: Species
name: H2O
has only substance units: false
initial amount: NaN
is: HMDB02111
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
is: SBO:0000247

metaM ksi l
is: SBO:0000247
name: keratan sulfate I
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
initial amount: NaN
is: CHEBI:57455
is: C00445
is: HMDB01354
has only substance units: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM nadph c
initial amount: NaN
has only substance units: false
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
is: HMDB00221
is: SBO:0000247
is: CHEBI:57783
initial concentration: 1.0

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR CYTK11n
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110060#
name: cytidylate kinase (dCMP,dGTP),nuclear
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110060#
is described by: ECO:0000269

metaR r1612
reactant: MODEL1310110060#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110060#

metaR r2364
type: Reaction
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110060#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110060#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_f51587a2_e4f5_46b8_ad5f_10aa655d215d
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:AA081045
is: SBO:0000252
has only substance units: false
name: _AA081045_1_c

metaR r0249
product: MODEL1310110060#
reversible: true
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
is: SBO:0000176
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.12
modifier: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
type: Reaction

metaR UPPN
is: SBO:0000176
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000269
kinetic law: MODEL1310110060#
name: b-ureidopropionase
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_3698583b_a861_405a_b793_3cc4d6141ef1
type: Species
initial concentration: NaN
is: B2RBR4
constant: false
is: SBO:0000252
name: SLC20A2
initial amount: NaN
boundary condition: true
is encoded by: hsa:6575
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6e443bde_60bc_413c_8855_1a105b62f3fc
has only substance units: false
name: DPAGT1
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:1798
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_2e4da499_4f5f_4e22_a21d_765f7d83b8eb
type: Species
is: P00374
name: DHFR
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1719
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM acnam c
initial amount: NaN
is: CHEBI:35418
is: HMDB00230
type: Species
has only substance units: false
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: N-acetylneuraminate

metaR 5ADTSTSTERONEte
reactant: MODEL1310110060#
reversible: true
kinetic law: MODEL1310110060#
name: 5 alpha dihydrotesterone transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110060#

metaR r0841
is: SBO:0000185
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
is described by: ECO:0000000
name: Free diffusion
is version of: http://identifiers.org/ec-code/1.1.1.271
reversible: true
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
modifier: MODEL1310110060#

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaR r0022
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110060#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is: SBO:0000176
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
fast: false

metaR r1613
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
fast: false
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_de47f9a7_1ccb_4ef2_b6ec_f6ea4a011d70
is: SBO:0000252
initial amount: NaN
name: HK1
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:3098
is: P78542

metaM gumgchol e
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00672
type: Species
boundary condition: false
notes: FORMULA: C2760026H5060043NO2530006 CHARGE: 0
initial concentration: 1.0
name: guar gum-glycocholate complex
initial amount: NaN
is: C08260

http://identifiers.org/biomodels.db/MODEL1310110060#_535ea087_f6da_414c_b898_9d574799ff9a
name: DCTD
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: P32321
type: Species
is encoded by: hsa:1635
initial concentration: NaN

metaR r2367
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaM pi e
is: C00009
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:43474
has only substance units: false
initial concentration: 1.0
name: hydrogenphosphate
is: HMDB00973
type: Species
initial amount: NaN

metaR LEUPHELAT2tc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM drib e
type: Species
is: CHEBI:28816
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB03224
constant: false
is: SBO:0000247
initial amount: NaN
name: 2-deoxy-D-ribose
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801

metaR r1692
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110060#
is: SBO:0000185
modifier: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#
is described by: ECO:0000000

metaM citr L c
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349
constant: false
boundary condition: false
name: L-citrulline
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00904

metaM galside hs c
is: CHEBI:12947
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species

metaR ACACT1x
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: false
product: MODEL1310110060#
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
reactant: MODEL1310110060#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110060#

metaM oaa c
constant: false
is: C00036
is: HMDB00223
has only substance units: false
type: Species
name: Oxaloacetate
is: CHEBI:3338
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H2O5 CHARGE: -2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_968df47e_43d0_46af_b598_205d181bc425
name: NDUFA7
constant: false
is: Q6FG42
boundary condition: true
is encoded by: hsa:4701
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

metaM dc2coa m
is: SBO:0000247
initial amount: NaN
is: CHEBI:61406
boundary condition: false
name: trans-Dec-2-enoyl-CoA
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
constant: false

metaM acgam l
is: HMDB00215
constant: false
is: CHEBI:17411
has only substance units: false
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: N-acetyl-D-glucosamine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_9ae7ea8d_212e_4d79_a8e8_4ff1391b51ef
initial amount: NaN
is: P11310
boundary condition: true
is: SBO:0000252
is encoded by: hsa:34
type: Species
has only substance units: false
name: ACADM
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_8e9738cd_5ea8_41b4_b693_10cc9e3ad136
boundary condition: true
initial concentration: NaN
type: Species
name: ZADH2
has only substance units: false
is: SBO:0000252
constant: false
is: Q4G1C4
is encoded by: hsa:284273
initial amount: NaN

metaR RE3005M
name: RE3005
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
fast: false
is: SBO:0000176

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB06487
has only substance units: false
name: pentaglutamyl folate (DHF)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_3f9ba817_b427_47fe_b250_6974cf3df5cb
boundary condition: true
type: Species
is: SBO:0000252
is: O60658
initial concentration: NaN
is encoded by: hsa:5151
initial amount: NaN
name: PDE8A
constant: false
has only substance units: false

metaR r0021
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
type: Reaction
product: MODEL1310110060#
modifier: MODEL1310110060#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
is: SBO:0000176
kinetic law: MODEL1310110060#

metaM cmp c
is: CHEBI:60377
has only substance units: false
initial concentration: 1.0
type: Species
is: C00055
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: CMP
is: HMDB00095

metaM co2 c
name: CO2
has only substance units: false
is: C00011
initial concentration: 1.0
type: Species
notes: FORMULA: CO2 CHARGE: 0
constant: false
is: HMDB01967
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:3313

metaM cdpdag hs c
name: CDP-diacylglycerol(2-)
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58332
has only substance units: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR r1614
reactant: MODEL1310110060#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110060#
modifier: MODEL1310110060#

metaR r0842
fast: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: Postulated transport reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.72
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
product: MODEL1310110060#
type: Reaction

metaR RE2079R
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reactant: MODEL1310110060#
name: RE2079
product: MODEL1310110060#
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
reversible: true

metaM 3ohdcoa m
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
is: HMDB06402
is: SBO:0000247
boundary condition: false
is: CHEBI:57349
type: Species
constant: false
has only substance units: false
name: 3-oxopalmitoyl-CoA(4-)
initial concentration: 1.0

metaM succoa x
boundary condition: false
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB01022
is: SBO:0000247

metaR GLRASE
name: glucuronolactone reductase
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110060#
is described by: ECO:0000000

metaR r2366
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110060#_dfe6ab6b_ce37_47e7_8800_05db4dc27c5d
type: Species
constant: false
is encoded by: hsa:8659
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ALDH4A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_53038975_9e1d_4935_a565_88b988973676
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:27034
name: ACAD8
is: Q6ZWP6
type: Species
initial amount: NaN

metaR RE0830N
modifier: MODEL1310110060#
name: RE0830
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110060#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110060#

metaM glc D c
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: HMDB00122
boundary condition: false
name: D-glucose
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_39b72b2b_e7a6_49c1_abc8_c6612d8548d1
initial concentration: NaN
boundary condition: true
is: O95822
is encoded by: hsa:23417
constant: false
has only substance units: false
initial amount: NaN
name: MLYCD
type: Species
is: SBO:0000252

metaR HMGLx
type: Reaction
product: MODEL1310110060#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.1.3.4
name: hydroxymethylglutaryl-CoA lyase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
reactant: MODEL1310110060#
modifier: MODEL1310110060#
fast: false

metaR CYOR u10m
reversible: false
name: ubiquinol-6 cytochrome c reductase, Complex III
fast: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_e607f238_03e5_4570_999a_5c6553cc8d3d
name: RDH11
boundary condition: true
constant: false
is encoded by: hsa:51109
is: B4DDW0
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_0deca360_7af3_4b04_a266_36197a6f40c7
initial concentration: NaN
boundary condition: true
name: SLC2A6
type: Species
has only substance units: false
is: SBO:0000252
is: Q9UGQ3
is encoded by: hsa:11182
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_3bb919ed_3704_4cc8_9e94_93e49decdbfc
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3038
name: HAS3
is: Q96RV2
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaM 2mpdhl m
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
is: CHEBI:17577
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_f1bf4058_1b3f_41de_b0e8_40ad49fbc357
is encoded by: hsa:84649
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: DGAT2
is: SBO:0000252
constant: false
has only substance units: false
is: Q96PD7

metaR PRO Dtde
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110060#
reversible: true
name: D-proline transport, extracellular
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false

metaR r2369
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
fast: false

metaR r0246
reactant: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is described by: ECO:0000000
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110060#_513de9fa_e44f_4055_9d19_f3e10bcff7d2
initial concentration: NaN
constant: false
is encoded by: hsa:83530
type: Species
initial amount: NaN
is: SBO:0000252
name: _83530_1_c
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_fe20c4ed_ef57_41dd_8366_bdd50467e84a
type: Species
name: _AV717590_1_c
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:AV717590
has only substance units: false
initial amount: NaN

metaR KSIt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#
name: keratan sulfate I transport, golgi to extracellular
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110060#
product: MODEL1310110060#

metaR GLPASE2
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5834.1) or (5836.1) or (5837.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.1 Confidence Level: 4 AUTHORS: PMID:3346228 NOTES:NCD
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
is: SBO:0000176
name: glycogen phosphorylase (amyls -> glc-D)
is version of: http://identifiers.org/ec-code/2.4.1.1
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM 3mob c
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
name: 3-methyl-2-oxobutanoate
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:11851
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00019

metaR G14T6g
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
reversible: false
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_d7b4316e_480c_4fb7_9050_bb850ffd3bfa
initial amount: NaN
is encoded by: hsa:4357
is: SBO:0000252
type: Species
constant: false
is: P25325
name: MPST
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM atp c
name: ATP(4-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:30616
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00538
type: Species
initial amount: NaN
is: C00002

metaM glu L c
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:29985
is: HMDB00148
type: Species
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false
initial amount: NaN
name: L-glutamate(1-)

metaR INSTt2r
is: SBO:0000185
product: MODEL1310110060#
reversible: true
name: inositol transport in via proton symport
type: Reaction
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
is described by: ECO:0000269
fast: false
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaM glc D e
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
is: HMDB00122
has only substance units: false
name: D-glucose

metaM cmp e
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
is: CHEBI:60377
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: CMP(2-)
is: HMDB00095

metaM co2 e
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
is: HMDB01967
is: SBO:0000247
is: CHEBI:16526
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: CO2

metaR DM ethamp r
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR CYTDt
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
reversible: true
product: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110060#
name: cytidine facilated transport in cytosol

metaR r2368
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
type: Reaction

metaM andrstandn r
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 5alpha-androstane-3,17-dione
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: HMDB00899
type: Species
is: CHEBI:15994

metaR r0245
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
fast: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_08102014_e1de_48f9_81a9_41a6522f1ad7
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: INPP5A
is: Q14642
is encoded by: hsa:3632
initial amount: NaN
type: Species

metaR RE0935E
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
is: SBO:0000176
product: MODEL1310110060#
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110060#
type: Reaction

metaR FAOXC200180m
name: Beta oxidation of long chain fatty acid
reversible: false
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110060#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaM mi145p c
boundary condition: false
initial concentration: 1.0
is: CHEBI:203600
has only substance units: false
type: Species
is: HMDB01498
constant: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: SBO:0000247
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
initial amount: NaN

metaM ksii core4 pre8 g
is: C00130
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 8
is: SBO:0000247
is: HMDB00175

metaR THCHOLSTOICtm
product: MODEL1310110060#
fast: false
reversible: true
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110060#
is: SBO:0000185

metaR RE2269E
is described by: ECO:0000000
fast: false
modifier: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.21.39
name: RE2269
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110060#

metaM ksi g
is: HMDB01014
is: CHEBI:57255
initial concentration: 1.0
type: Species
name: keratan sulfate I
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_edb227b5_f43c_489c_8a1b_3b99c4446f83
name: DGKH
initial concentration: NaN
is: SBO:0000252
is: A8K0I1
boundary condition: true
has only substance units: false
is encoded by: hsa:160851
constant: false
type: Species
initial amount: NaN

metaR NRPPHRtu
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000269
product: MODEL1310110060#
is: SBO:0000185
name: Norepinephrine uniport

metaR DNDPt25m
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dCDP antiport

metaM hista e
is: HMDB00870
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
constant: false
is: CHEBI:58432
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: histamium
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_a5813f28_9b5a_491f_bbb5_088cff4e20dd
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AA788780_1_c
boundary condition: true
is encoded by: hsa:AA788780

metaR r2407
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
is described by: ECO:0000000
reversible: false

metaM stcoa c
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01114
name: Stearoyl-CoA (n-C18:0CoA)
boundary condition: false
is: C00412
has only substance units: false
type: Species
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: CHEBI:57394
initial concentration: 1.0

metaR NDPK4n
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
fast: false

metaR RE2625M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110060#
name: RE2625
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
kinetic law: MODEL1310110060#
type: Reaction
fast: false
reactant: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
is described by: ECO:0000000

metaR r0845
type: Reaction
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7

metaM h2o l
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: water
is: HMDB02111
constant: false
boundary condition: false
is: CHEBI:15377
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_710b45c0_fbe0_4ec7_a082_f3fafc8c5ced
name: CHAT
is encoded by: hsa:1103
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: P28329
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_74757ce1_c00f_4627_b4f1_c764d42de8c1
boundary condition: true
name: _AW299740_1_m
is: SBO:0000252
is encoded by: hsa:AW299740
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR H2O2t
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
is: SBO:0000185
name: hydrogen peroxide transport via diffusion
product: MODEL1310110060#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF

http://identifiers.org/biomodels.db/MODEL1310110060#_765ded73_5ace_4536_bf7c_55a3e11f7518
is: SBO:0000252
is: P09417
name: QDPR
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5860

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR S6T1g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110060#
reversible: false
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110060#
type: Reaction

metaR PROSTGI2t
is: SBO:0000185
name: Prostaglandin I2 transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110060#
is described by: ECO:0000269
fast: false
reversible: true
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaM 3mob e
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:11851
is: HMDB00019
name: 3-methyl-2-oxobutanoate

metaM atp e
initial concentration: 1.0
boundary condition: false
name: ATP(4-)
constant: false
is: SBO:0000247
is: HMDB00538
has only substance units: false
type: Species
is: CHEBI:57299
initial amount: NaN
is: C00002

http://identifiers.org/biomodels.db/MODEL1310110060#_9bf488d2_28a6_4380_8a0b_f0506055e166
initial amount: NaN
name: _H77542_1_r
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:H77542
initial concentration: NaN
constant: false

metaR S6TASE20ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaM hista c
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: histamium
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
constant: false
type: Species
is: CHEBI:58432
initial concentration: 1.0
is: HMDB00870

metaR ALAtN1
product: MODEL1310110060#
modifier: MODEL1310110060#
name: Alanine transport (Na, H coupled)
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
reversible: true

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR r2408
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110060#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
modifier: MODEL1310110060#
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#

metaM cmp g
name: CMP(2-)
is: SBO:0000247
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00095
constant: false
has only substance units: false

metaR r1610
product: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110060#

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM glu L e
is: HMDB00148
is: CHEBI:29985
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false
constant: false
is: SBO:0000247
name: L-glutamate(1-)

http://identifiers.org/biomodels.db/MODEL1310110060#_50aae242_456d_4afb_a50c_281d90ad9584
type: Species
is encoded by: hsa:1375
name: CPT1B
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: E9PCP2
constant: false
initial concentration: NaN

metaR r1763
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000
modifier: MODEL1310110060#
name: Y+LAT2 Utilized transport

metaM sbt D e
type: Species
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
name: D-glucitol
is: HMDB00247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_82616f34_21d2_4218_aed0_9c750cb82576
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:3417
name: IDH1
initial amount: NaN
boundary condition: true
is: O75874

http://identifiers.org/biomodels.db/MODEL1310110060#_8978ac01_9b8b_4560_9f10_6ac476e04a9d
is encoded by: hsa:2679
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: GGT3P
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_c2311cdf_d6e5_4b74_85a6_a1698b5f0f45
is encoded by: hsa:341947
initial amount: NaN
boundary condition: true
is: Q7Z4L0
constant: false
name: COX8C
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaR PYRt2m
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
type: Reaction
reversible: true
name: pyruvate mitochondrial transport via proton symport
is: SBO:0000185
modifier: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#

metaM arachcoa c
constant: false
is: CHEBI:15527
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
type: Species
is: SBO:0000247
initial amount: NaN

metaR DOLPMT U
kinetic law: MODEL1310110060#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.83
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
reversible: false
product: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#

metaR HIBDm
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.31
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
kinetic law: MODEL1310110060#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
modifier: MODEL1310110060#
type: Reaction
fast: false
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial

metaR r0355
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
is described by: ECO:0000000

metaM hgentis c
initial amount: NaN
is: CHEBI:16169
initial concentration: 1.0
has only substance units: false
name: homogentisate
type: Species
boundary condition: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
is: SBO:0000247
constant: false
is: HMDB00130

http://identifiers.org/biomodels.db/MODEL1310110060#_9662f60d_432f_4b46_89f2_e510a789bb45
is: P00390
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2936
constant: false
name: GSR
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR r0413
reactant: MODEL1310110060#
modifier: MODEL1310110060#
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
kinetic law: MODEL1310110060#
product: MODEL1310110060#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000

metaM succoa m
is: CHEBI:57292
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: Succinyl-CoA
is: HMDB01022
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091

metaM hco3 m
is: SBO:0000247
is: C00288
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
name: Bicarbonate
constant: false
is: CHEBI:17544
initial amount: NaN
is: HMDB00595

metaR ABUTt2r
reversible: true
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
is: SBO:0000185
fast: false
name: 4-aminobutyrate reversible transport in via proton symport
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR S6TASE16ly
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110060#

metaM 3ohdcoa x
is: CHEBI:57349
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
name: 3-oxopalmitoyl-CoA(4-)
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: HMDB06402
initial concentration: 1.0
type: Species
constant: false

metaM acac c
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
type: Species
name: acetoacetate
is: CHEBI:13705
initial amount: NaN

metaR LYStip
fast: false
product: MODEL1310110060#
type: Reaction
reversible: false
kinetic law: MODEL1310110060#
name: L-lysine transport, peroxisomal (irreversible)
is described by: ECO:0000000
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110060#_787f771c_f383_4dcb_ab43_25b25f020092
is: SBO:0000252
name: PPCS
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:79717
boundary condition: true
is: Q9HAB8
initial amount: NaN

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM chito2pdol U c
initial amount: NaN
constant: false
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
initial concentration: 1.0
is: CHEBI:12427
type: Species
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_d25801d2_1ce1_4477_9d52_9b0b571ea1ca
is: SBO:0000252
is encoded by: hsa:BE042354
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _BE042354_1_m
type: Species
constant: false

metaM oaa m
initial amount: NaN
is: C00036
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00223
initial concentration: 1.0
is: CHEBI:16452
name: Oxaloacetate
constant: false

metaR DIGALSGALSIDEtg
name: digalsgalside hs intracellular transport
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185

metaR GLUDym
is: SBO:0000176
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
fast: false
product: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reversible: true
type: Reaction
name: glutamate dehydrogenase (NADP), mitochondrial

metaR r0354
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110060#
reversible: false
modifier: MODEL1310110060#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM h2o e
constant: false
name: H2O
boundary condition: false
is: CHEBI:15377
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00001
has only substance units: false
is: HMDB02111
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaM xoltriol c
is: CHEBI:16496
initial amount: NaN
is: HMDB01457
boundary condition: false
constant: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_79b2b462_5457_458d_b6dd_060cca752716
name: LDHA:LDHB
is encoded by: hsa:3945
has only substance units: false
is encoded by: hsa:3939
constant: false
type: Species
is: SBO:0000297
boundary condition: true
has part: P07195
initial concentration: NaN
has part: P00338
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_17ee81cd_a700_4ef3_af5a_e3c54d0981d1
has only substance units: false
initial amount: NaN
is: Q7LG56
is encoded by: hsa:50484
initial concentration: NaN
boundary condition: true
constant: false
name: RRM2B
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_3dacdf90_ae2a_45d7_963a_46ac613d206a
constant: false
is: P31939
name: ATIC
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:471
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM ksi pre23 g
type: Species
initial concentration: 1.0
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 23
boundary condition: false
constant: false
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR SUCOAS1m
name: Succinate--CoA ligase (GDP-forming)
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
reactant: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_7ac63ee3_9fd5_4432_8dbf_f5c71dccd791
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: SULT1A3
is encoded by: hsa:6818
is: P50224
constant: false
has only substance units: false

metaM ksii core4 deg1 l
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
is: HMDB00868
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate II (core 4-linked), degradation product 1
is: CHEBI:57737
initial amount: NaN
initial concentration: 1.0

metaR r1766
modifier: MODEL1310110060#
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110060#
kinetic law: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_721125db_5f5d_4cf4_8ede_01aaa25a7536
is: SBO:0000252
initial amount: NaN
is: P30043
constant: false
name: BLVRB
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:645
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_74f6d7ff_e021_42ff_b786_cb8d7a0910ec
is encoded by: hsa:4717
is: O43677
has only substance units: false
name: NDUFC1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaM dgdp m
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: CHEBI:58595
has only substance units: false
name: dGDP(2-)
initial amount: NaN

metaR r0494
is: SBO:0000176
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
fast: false
reactant: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#

metaR r0560
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
product: MODEL1310110060#
is described by: ECO:0000000
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
type: Reaction
is: SBO:0000176

metaR r2403
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110060#
reversible: false
product: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_54e857f5_9191_4d82_814b_33848f85c38d
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: P14854
is encoded by: hsa:1340
name: COX6B1
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM ksi deg20 l
initial concentration: 1.0
name: keratan sulfate I, degradation product 20
initial amount: NaN
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: HMDB00143
is: SBO:0000247
boundary condition: false
type: Species
constant: false

metaM fald e
boundary condition: false
is: SBO:0000247
is: CHEBI:16842
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false
constant: false
is: HMDB01426
type: Species
name: formaldehyde
initial concentration: 1.0
initial amount: NaN

metaR r0779
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110060#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
product: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_352fc432_7366_4c70_8c3d_e8f19801854e
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7296
has only substance units: false
is: Q16881
initial concentration: NaN
type: Species
name: TXNRD1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_02fcf9de_ded2_4d32_8630_71474d047273
type: Species
is: SBO:0000252
has only substance units: false
name: NDUFA4L2
boundary condition: true
is: Q9NRX3
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:56901

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: Transport of (R)-Pantothenate
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110060#
fast: false
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_7cffb252_1ade_454e_9f73_fba866dd2f92
is: SBO:0000252
initial concentration: NaN
constant: false
name: HK1
is: A8K7J7
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:3098
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_80177ef8_4c6b_4c22_bf61_bc40ffba6195
initial amount: NaN
is: SBO:0000252
name: UCK1
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: Q5JT09
is encoded by: hsa:83549

metaM dgdp n
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
is: SBO:0000247
is: HMDB00960
constant: false
name: dGDP(2-)
type: Species
initial concentration: 1.0
is: CHEBI:58595

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR GLUPROASCT1
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
is: SBO:0000185
reactant: MODEL1310110060#
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
name: glutamate intake by system ASCT-1 transporter
product: MODEL1310110060#
type: Reaction

metaM h2o g
boundary condition: false
name: water
is: HMDB02111
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_67017c18_2525_4724_b424_8852f2c11011
type: Species
is: SBO:0000252
is: B1AK53
constant: false
boundary condition: true
name: ESPN
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:83715
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_57625a13_a203_4564_9b9b_4a7134b04bc3
type: Species
initial amount: NaN
is encoded by: hsa:11001
is: SBO:0000252
is: O14975
initial concentration: NaN
constant: false
name: SLC27A2
boundary condition: true
has only substance units: false

metaR DIGALSGALSIDEte
is: SBO:0000185
kinetic law: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
name: digalsgalside hs transport
product: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_789ed493_8db3_4b69_b776_63cdbb90f845
is: SBO:0000252
type: Species
is encoded by: hsa:30833
name: NT5C
is: Q8TCD5
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaR biomass reaction
reversible: false
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
name: biomass_reaction
kinetic law: MODEL1310110060#
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:

metaM adrncoa x
is: C16170
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
initial amount: NaN
constant: false
name: adrenyl coenzyme A
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480

metaR UDPtl
type: Reaction
reversible: true
reactant: MODEL1310110060#
fast: false
name: udp intracellular transport
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ

http://identifiers.org/biomodels.db/MODEL1310110060#_be013dd4_e7f5_4a54_b3b0_f14f88dd94cc
name: COX4I1
constant: false
initial concentration: NaN
has only substance units: false
is: P13073
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:1327
type: Species

metaR RE0453C
kinetic law: MODEL1310110060#
is: SBO:0000176
name: RE0453
type: Reaction
fast: false
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reactant: MODEL1310110060#

metaR TCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
is: SBO:0000185
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
kinetic law: MODEL1310110060#
name: bile acid intracellular transport
is described by: ECO:0000000
reversible: true

metaM ksi deg36 l
is: HMDB00143
boundary condition: false
is: CHEBI:12936
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 36
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C62H103N4O49S1 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110060#_6121ecaf_8c53_4a55_b897_74282e0caf80
is encoded by: hsa:3158
is: SBO:0000252
has only substance units: false
boundary condition: true
name: HMGCS2
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P54868

http://identifiers.org/biomodels.db/MODEL1310110060#_f663237c_e9bd_4e96_a384_5ffd400e4921
is encoded by: hsa:8854
initial concentration: NaN
is: B4DZR2
type: Species
name: ALDH1A2
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_cb0797ec_829a_400d_8fc2_759676167750
is: P03905
boundary condition: true
is encoded by: hsa:4538
constant: false
initial amount: NaN
name: ND4
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR IDOAASE2ly
name: alpha-L-iduronidase, lysosomal
kinetic law: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
fast: false
product: MODEL1310110060#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76

metaR XOL27OHtm
kinetic law: MODEL1310110060#
name: 27 hydroxy cholesterol transport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

metaR MACACI
reactant: MODEL1310110060#
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
name: maleylacetoacetate isomerase
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
kinetic law: MODEL1310110060#
type: Reaction
product: MODEL1310110060#

metaM acgam r
type: Species
name: N-acetyl-D-glucosamine
is: SBO:0000247
boundary condition: false
is: CHEBI:17411
has only substance units: false
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
initial concentration: 1.0
initial amount: NaN

metaM stcoa m
name: Stearoyl-CoA (n-C18:0CoA)
is: C00412
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: SBO:0000247
type: Species
is: HMDB01114
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57394
boundary condition: false
constant: false

metaR ARACHt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110060#
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_d85b6f16_a28c_4661_9cfe_a0d99b356e71
has part: P21912
is encoded by: hsa:6391
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SDHA:SDHB:SDHC:SDHD
has part: O14521
constant: false
is encoded by: hsa:6390
is encoded by: hsa:6389
is encoded by: hsa:6392
has part: P31040
type: Species
is: SBO:0000297
has part: Q99643

metaM galside hs e
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: D-galactosyl-N-acylsphingosine
boundary condition: false

metaR DOLPMT4 Uer
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110060#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110060#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110060#

metaR GCALDD
name: Glycolaldehyde dehydrogenase
modifier: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110060#

metaM leuktrF4 e
has only substance units: false
name: leukotriene F4
constant: false
is: CHEBI:27491
is: SBO:0000247
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
is: HMDB06465
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM sbcoa x
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: C14143
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
name: suberylcoa
is: HMDB04047

metaR ITCOALm
kinetic law: MODEL1310110060#
is: SBO:0000176
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
product: MODEL1310110060#
modifier: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5

metaR LPCHOLt
fast: false
kinetic law: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
name: lysophosphatidylcholine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
is described by: ECO:0000000
type: Reaction

metaM CE2705 n
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:15374
is: HMDB02281
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial amount: NaN
constant: false
type: Species
name: quinonoid dihydrobiopterin

metaM 10fthf5glu e
boundary condition: false
initial amount: NaN
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57454
type: Species
is: HMDB00972
name: 10-formyltetrahydrofolate-[Glu](5)

metaR r2361
type: Reaction
fast: false
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_34bf2336_efa6_446c_9405_e0959fbd1ddd
name: FOLR1
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:2348
is: SBO:0000252

metaM 2obut m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
initial amount: NaN
is: HMDB00005
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:16763
has only substance units: false
type: Species
name: 2-oxobutanoate

http://identifiers.org/biomodels.db/MODEL1310110060#_64015ac6_775e_444e_a63e_21713cd3af16
is: SBO:0000252
initial concentration: NaN
name: _22305_1_c
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:22305

metaR PMANM
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.4.2.8
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
name: phosphomannomutase
is version of: http://identifiers.org/ec-code/5.4.2.2
fast: false
reversible: true
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110060#

metaM fald l
name: formaldehyde
boundary condition: false
constant: false
is: CHEBI:16842
is: SBO:0000247
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: HMDB01426
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

metaM cmp n
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
is: SBO:0000247
initial amount: NaN
constant: false
name: CMP(2-)
is: HMDB00095
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_3fd26057_d88e_4da8_89dd_5edd5f9e319e
is encoded by: hsa:92483
initial concentration: NaN
name: LDHAL6B
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: Q9BYZ2
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110060#_9e8651a4_3b4d_4ce5_b805_b7c1ab8acea0
is encoded by: hsa:AV727634
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: _AV727634_1_c
initial concentration: NaN
is: SBO:0000252

metaM 4mop m
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
type: Species
is: HMDB00695
initial concentration: 1.0
is: CHEBI:17865
has only substance units: false
name: 4-methyl-2-oxopentanoate
is: SBO:0000247

metaM thyox L e
is: CHEBI:18332
constant: false
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: HMDB00248
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR CYTK1m
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
type: Reaction
reversible: true
fast: false
name: cytidylate kinase (CMP),mitochondrial
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#

metaR PYRt2p
name: pyruvate peroxisomal transport via proton symport
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
is: SBO:0000185

metaR r0410
is described by: ECO:0000000
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
fast: false
type: Reaction

metaR BTND1n
is version of: http://identifiers.org/ec-code/3.5.1.12
type: Reaction
name: biotinidase (biotin), nuclear
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
kinetic law: MODEL1310110060#
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110060#_8b43bf14_56a1_4759_b51e_cb234231f977
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54677
initial amount: NaN
name: CROT
boundary condition: true
constant: false
type: Species
is: E7EQF2
is: SBO:0000252

metaR r2360
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110060#
reversible: true
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false

metaM 5mthf e
has only substance units: false
initial amount: NaN
name: 5-Methyltetrahydrofolate
constant: false
is: HMDB01396
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: CHEBI:3729
is: C00440

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM pi c
constant: false
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
name: hydrogenphosphate
is: C00009
has only substance units: false
is: CHEBI:43474
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00973
is: SBO:0000247

metaR CH25H
product: MODEL1310110060#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.14.99.38
is described by: ECO:0000269
reactant: MODEL1310110060#
name: cholesterol 25-hydroxylase

metaM co2 m
is: CHEBI:16526
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
name: CO2
is: C00011
boundary condition: false

metaM cmp m
name: CMP(2-)
type: Species
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00095

http://identifiers.org/biomodels.db/MODEL1310110060#_2c45d29d_096a_4b6d_8ed1_0f9c6159ef38
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:8875
name: VNN2
initial amount: NaN
is: O95498
has only substance units: false

metaM CE5162 r
type: Species
name: trans,cis-2,9-octadecadienoyl-CoA
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:12947
is: SBO:0000247
initial concentration: 1.0

metaM 3odcoa m
is: SBO:0000247
is: CHEBI:28528
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: HMDB03939
name: 3-Oxodecanoyl-CoA
type: Species

metaM so4 l
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
type: Species
name: sulfate
is: SBO:0000247
initial amount: NaN
is: CHEBI:16189
initial concentration: 1.0
has only substance units: false
is: HMDB01448

http://identifiers.org/biomodels.db/MODEL1310110060#_5f63115f_6c9c_48f0_9a3c_32c26a76b9d5
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: SI
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6476
has only substance units: false
is: P14410

metaR ACHtn
reversible: true
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110060#

metaR r2363
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110060#
is: SBO:0000185
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110060#
product: MODEL1310110060#

metaR r0998
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
product: MODEL1310110060#
name: Facilitated diffusion
reversible: true
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110060#

metaM galside hs g
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_19eb07e6_1309_4406_942b_f8afd06930ac
is: SBO:0000252
constant: false
has only substance units: false
type: Species
name: ADCY6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:112
initial amount: NaN

metaM m5mpdol U r
is: CHEBI:37634
is: SBO:0000247
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaR CYTK1n
type: Reaction
reversible: true
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
product: MODEL1310110060#
reactant: MODEL1310110060#

metaR GGT6
name: Gamma-glutamyltransferase
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
type: Reaction

metaM lac D c
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: HMDB01311
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: (R)-lactate
is: CHEBI:16004
boundary condition: false

metaR C204CPT2
type: Reaction
is described by: ECO:0000000
name: arachidonic acid transport into the mitochondria
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
reversible: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_2bffb977_b268_4eba_8b77_371fedb30f58
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:6582
has only substance units: false
name: SLC22A2
boundary condition: true
initial amount: NaN

metaR O16G1e
is: SBO:0000176
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
product: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.10
reversible: false
modifier: MODEL1310110060#

metaM 7thf e
notes: FORMULA: C49H57N13O24 CHARGE: -8
boundary condition: false
has only substance units: false
name: heptaglutamyl folate (THF)
constant: false
is: HMDB06559
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

metaR DURAD2
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.1.2
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
name: dihydrothymin dehydrogenase (NADP)
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: true

metaR BTNPL
is described by: ECO:0000000
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
name: holocarboxylase synthestase (biotin protein ligase)
is: SBO:0000176
type: Reaction
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reversible: false

metaM 2dr1p c
type: Species
name: 2-Deoxy-D-ribose 1-phosphate
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01351
is: C00672
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN
boundary condition: false
is: CHEBI:58576
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_ddc1b903_bf6e_465e_aa8a_95c8f1656b0a
initial amount: NaN
type: Species
name: DGKZ
has only substance units: false
is encoded by: hsa:8525
is: SBO:0000252
boundary condition: true
is: B7Z6M3
initial concentration: NaN
constant: false

metaM cdp c
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP
is: C00112
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01546
initial amount: NaN
is: CHEBI:58069
boundary condition: false
has only substance units: false

metaM sql r
has only substance units: false
name: squalene
type: Species
is: CHEBI:15440
boundary condition: false
is: SBO:0000247
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
constant: false
initial concentration: 1.0
is: HMDB00256
initial amount: NaN

metaM thyox L c
initial amount: NaN
name: L-thyroxine
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247
is: HMDB00248
initial concentration: 1.0
is: CHEBI:18332
constant: false

metaM h2o c
notes: FORMULA: H2O CHARGE: 0
is: CHEBI:3303
initial amount: NaN
boundary condition: false
name: H2O
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB02111
type: Species
is: C00001

metaM so4 m
is: HMDB01448
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
boundary condition: false
is: CHEBI:16189
type: Species
is: SBO:0000247
initial concentration: 1.0
name: sulfate
initial amount: NaN

metaR CYTDn
is: SBO:0000176
is described by: ECO:0000254
fast: false
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:
name: cytidine deaminase, nuclear
type: Reaction
reversible: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110060#
modifier: MODEL1310110060#

metaR r2362
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction

metaR r0130
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
type: Reaction
reversible: true
product: MODEL1310110060#
fast: false

metaR r0774
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
kinetic law: MODEL1310110060#
reversible: true
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reactant: MODEL1310110060#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
product: MODEL1310110060#
type: Reaction
fast: false

metaR r0999
type: Reaction
name: Facilitated diffusion
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_c327ee17_07fe_418f_bf06_7a62a7f22ce4
is: P51178
initial amount: NaN
name: PLCD1
has only substance units: false
constant: false
is encoded by: hsa:5333
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r1051
reactant: MODEL1310110060#
name: Vesicular transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110060#

metaR MECOAS1m
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110060#
fast: false
name: mesaconate--CoA ligase (GDP-forming)
reversible: true
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR AG13T1g
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
product: MODEL1310110060#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110060#_74e126e4_0902_43bc_8fcd_e4657c74c153
name: PDE9A
is encoded by: hsa:5152
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM pi x
is: HMDB00973
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: CHEBI:43474
initial amount: NaN
type: Species
name: hydrogenphosphate
has only substance units: false
constant: false

metaM hspg e
is: HMDB00719
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: CHEBI:15699
name: heparan sulfate proteoglycan

metaM ha e
is: CHEBI:16336
type: Species
is: SBO:0000247
initial concentration: 1.0
name: hyaluronan
constant: false
has only substance units: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
initial amount: NaN

metaM dhcrm hs c
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
type: Species
name: dihydroceramide
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:31488
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_093aa378_ac9d_4e6f_9411_05a822a1118f
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: _PRO1933_1_m
is encoded by: hsa:PRO1933
boundary condition: true
has only substance units: false
constant: false

metaR r0915
kinetic law: MODEL1310110060#
fast: false
product: MODEL1310110060#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_b2cc108b_29ea_4891_a4a8_238652c69db3
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: PKM2
is: SBO:0000252
is encoded by: hsa:5315
is: B4DNK4
has only substance units: false
boundary condition: true

metaR RE3218C
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
type: Reaction
fast: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
name: RE3218
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.2
is described by: ECO:0000000
modifier: MODEL1310110060#
reactant: MODEL1310110060#

metaM mi1p D c
is: CHEBI:58433
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
has only substance units: false
name: 1D-myo-inositol 1-phosphate(2-)
is: HMDB02985
initial amount: NaN

metaR r1547
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110060#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true

metaR GLNyLATthc
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM glyclt x
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:29805
type: Species
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
name: glycolate
boundary condition: false
is: HMDB00115
has only substance units: false

metaR VALt5m
type: Reaction
name: Valine reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110060#
is: SBO:0000185
reactant: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
fast: false

metaM m2mpdol U c
initial concentration: 1.0
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:28049
constant: false
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20

metaM gly c
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00123
boundary condition: false
has only substance units: false
is: C00037
name: Glycine
initial concentration: 1.0
constant: false
is: CHEBI:3339

metaM co2 r
has only substance units: false
initial concentration: 1.0
name: CO2
is: HMDB01967
is: C00011
initial amount: NaN
type: Species
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
constant: false
is: SBO:0000247

metaR RE2651R
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110060#
is described by: ECO:0000000
name: RE2651
is: SBO:0000176
product: MODEL1310110060#
kinetic law: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_bc4acc00_6248_4958_bc7f_fbe6fa4a9f05
boundary condition: true
is: P21953
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:594
type: Species
initial amount: NaN
name: BCKDHB
is: SBO:0000252

metaM xoltriol m
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: CHEBI:16496
has only substance units: false
is: HMDB01457
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

metaR r2044
reversible: false
kinetic law: MODEL1310110060#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110060#
is: SBO:0000185
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_008e22ea_136a_4948_b133_0827b1566bb7
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5152
name: PDE9A
initial amount: NaN
boundary condition: true

metaM lnlncg e
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: gamma-linolenate
has only substance units: false
is: CHEBI:32391
is: HMDB03073
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-

metaR EX 3ddcrn
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_fe5ac313_a6bf_48a4_a848_0e64f9fa7f83
has only substance units: false
type: Species
initial amount: NaN
name: OXSM
constant: false
is encoded by: hsa:54995
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q9NWU1

metaM 2oxoadp m
type: Species
name: 2-oxoadipate(2-)
is: HMDB00225
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:57499

metaR GALt4
product: MODEL1310110060#
reversible: true
fast: false
modifier: MODEL1310110060#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
name: galactose transport via sodium symport

metaR RE1517M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
name: RE1517
is described by: ECO:0000000
kinetic law: MODEL1310110060#
type: Reaction
modifier: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_4bc9afd6_cbe4_497c_a33a_9a6b490bf3a0
name: CA9
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q16790
is encoded by: hsa:768
initial amount: NaN
has only substance units: false

metaR RE1523M
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
kinetic law: MODEL1310110060#
name: RE1523
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_44de2c03_96bc_4abc_ac81_8345cb17227d
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:28976
name: ACAD9
has only substance units: false
boundary condition: true
is: Q9H845
constant: false

metaR r1546
is: SBO:0000185
fast: false
product: MODEL1310110060#
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#

metaM udp c
initial concentration: 1.0
is: CHEBI:58223
boundary condition: false
is: C00015
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00295
name: UDP

metaM fuc1p L c
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
constant: false
is: HMDB01265
name: L-Fucose 1-phosphate
is: CHEBI:28319
initial concentration: 1.0
initial amount: NaN
type: Species

metaR BAMPPALDOX
kinetic law: MODEL1310110060#
is: SBO:0000176
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is described by: ECO:0000212
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
product: MODEL1310110060#
reactant: MODEL1310110060#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36

metaM ksii core2 pre5 g
is: C00130
boundary condition: false
constant: false
name: keratan sulfate II biosynthesis, precursor 5
initial concentration: 1.0
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
is: HMDB00175
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR NACHEX23ly
reactant: MODEL1310110060#
product: MODEL1310110060#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110060#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_e3529190_fea9_47ce_9224_28a71a69d1d5
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:28231
is: Q96BD0
constant: false
is: SBO:0000252
boundary condition: true
name: SLCO4A1

metaM malttr e
is: CHEBI:27931
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: HMDB01262
constant: false
has only substance units: false
boundary condition: false
name: maltotriose
is: C01835
initial amount: NaN
type: Species

metaR OCTAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
is described by: ECO:0000000
name: Octanoate transport via diffusion
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000185
reactant: MODEL1310110060#
type: Reaction
product: MODEL1310110060#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_fbf2ad0e_3795_4f7b_843b_8c8db14ef9db
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: P00326
is: SBO:0000252
boundary condition: true
type: Species
name: ADH1C
is encoded by: hsa:126

metaM dcsptn1coa c
is: SBO:0000247
type: Species
is: C16173
boundary condition: false
has only substance units: false
is: HMDB06513
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

metaM prostgf2 e
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57404
name: prostaglandin F2alpha(1-)
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01139
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

metaM hs deg15 l
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
has only substance units: false
name: heparan sulfate, degradation product 15
initial amount: NaN
is: CHEBI:16126
initial concentration: 1.0
type: Species

metaM pail hs n
is: CHEBI:57880
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
initial concentration: 1.0

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM 5mthf c
is: HMDB01396
is: CHEBI:3729
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
initial amount: NaN
is: C00440
boundary condition: false

metaR r0917
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110060#
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110060#_ac58a25c_691c_4693_a6bd_15b5f769e469
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: P28332
is encoded by: hsa:130
is: SBO:0000252
name: ADH6
has only substance units: false

metaR r1549
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ps hs e
type: Species
initial amount: NaN
constant: false
is: CHEBI:18303
is: SBO:0000247
boundary condition: false
name: phosphatidylserine
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0

metaM gly e
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
is: HMDB00123
type: Species
boundary condition: false
is: C00037
has only substance units: false
constant: false
name: Glycine
is: CHEBI:3339
initial concentration: 1.0

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_96aa2052_09eb_477c_9050_8fb344b6939d
type: Species
name: NDUFB4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4710
boundary condition: true
has only substance units: false
constant: false
is: O95168
is: SBO:0000252

metaM gthox m
type: Species
is: CHEBI:58297
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB03337

metaR DCMPDA
fast: false
kinetic law: MODEL1310110060#
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
name: dCMP deaminase
is version of: http://identifiers.org/ec-code/3.5.4.12
is described by: ECO:0000254
reactant: MODEL1310110060#
product: MODEL1310110060#

metaR GTHRDt
product: MODEL1310110060#
name: Glutathione transport into mitochondria
reactant: MODEL1310110060#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.

http://identifiers.org/biomodels.db/MODEL1310110060#_a133fd1d_b2a9_4d99_8929_1fb212aa2075
boundary condition: true
initial concentration: NaN
has part: P15531
is encoded by: hsa:4831
type: Species
name: NME1:NME2
has only substance units: false
is: SBO:0000297
initial amount: NaN
constant: false
has part: P22392
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110060#_4a9441d1_68e4_4ee0_ae67_2ac7dd306a47
boundary condition: true
is encoded by: hsa:23236
initial amount: NaN
constant: false
name: PLCB1
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR NS26T2g
fast: false
reversible: false
modifier: MODEL1310110060#
is: SBO:0000176
reactant: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.4.99.3
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
product: MODEL1310110060#

metaM arachcoa m
type: Species
name: arachidyl coenzyme A
is: HMDB04258
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15527
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041

http://identifiers.org/biomodels.db/MODEL1310110060#_70d439cf_844b_4e6a_a5e0_525f4fbd0f99
constant: false
name: AGL
initial concentration: NaN
is encoded by: hsa:178
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR GALASE3ly
fast: false
reactant: MODEL1310110060#
is: SBO:0000176
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false

metaR CRNtx
name: carnitine transport peroxisome to mitochondria
is: SBO:0000185
product: MODEL1310110060#
reactant: MODEL1310110060#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ

metaR 34DHXMANDACOX
is described by: ECO:0000269
reversible: false
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110060#
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110060#_561f902a_10b3_4f22_912b_f102743f0f2d
constant: false
name: ST3GAL3
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6487
has only substance units: false
boundary condition: true
initial amount: NaN

metaR r1913
is: SBO:0000185
type: Reaction
reversible: false
kinetic law: MODEL1310110060#
product: MODEL1310110060#
reactant: MODEL1310110060#
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110060#

metaR r1548
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110060#
kinetic law: MODEL1310110060#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110060#
is: SBO:0000185

metaM HC02204 c
is: CHEBI:27624
name: prostaglandin-b1
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r0097
reversible: false
is described by: ECO:0000000
product: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
reactant: MODEL1310110060#
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
type: Reaction
kinetic law: MODEL1310110060#
fast: false

metaR GGLUCT
kinetic law: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#
reversible: false
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.3.2.4
name: gamma-glutamylcyclotransferase
is described by: ECO:0000269

metaR DESAT22 1p
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110060#
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_21ed0926_6f7a_469d_98a7_bbcc579066d5
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:206
type: Species
is: SBO:0000252
has only substance units: false
name: _206_1_c
boundary condition: true

metaM lnlncg c
initial amount: NaN
name: gamma-linolenate
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:32391
is: HMDB03073
has only substance units: false
boundary condition: false

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR 3HCO3 NAt
type: Reaction
name: 3HCO3_NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
product: MODEL1310110060#
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6b2612bf_d342_4fe9_a859_37631e939ee0
constant: false
has part: P22392
has part: P15531
initial amount: NaN
is encoded by: hsa:4830
has only substance units: false
is encoded by: hsa:4831
type: Species
is: SBO:0000297
name: NME1:NME2
boundary condition: true
initial concentration: NaN

metaM 5fthf m
initial amount: NaN
name: 5-formyltetrahydrofolate(2-)
type: Species
is: CHEBI:57457
is: HMDB01562
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

metaM pail4p hs c
boundary condition: false
is: SBO:0000247
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_c2a3a727_8f3b_41fc_98fb_a1c731454e30
constant: false
name: SLC6A9
is encoded by: hsa:6536
type: Species
is: B7Z3W8
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110060#_34c600ce_5f77_4c73_85a3_c6cc7b5d3d53
type: Species
name: _AA576959_1_c
is: SBO:0000252
is encoded by: hsa:AA576959
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaR LCADi D
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110060#
type: Reaction
reactant: MODEL1310110060#
modifier: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.36
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110060#_3fcd70f2_4e98_42e1_92ce_2534ec1b9524
is: P11168
initial amount: NaN
name: SLC2A2
type: Species
is: SBO:0000252
is encoded by: hsa:6514
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM ps hs c
is: CHEBI:18303
name: ps_hs[c]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaM xolest2 hs e
type: Species
constant: false
initial amount: NaN
is: CHEBI:17002
name: cholesterol ester
has only substance units: false
boundary condition: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0

metaR GGH 10FTHF6GLUe
type: Reaction
reversible: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110060#
is: SBO:0000176
modifier: MODEL1310110060#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110060#

metaM ksi pre18 g
is: HMDB00175
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 18
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
type: Species
is: SBO:0000247
is: C00130

metaR r1886
is described by: ECO:0000000
reactant: MODEL1310110060#
name: Y+LAT2 Utilized transport
fast: false
reversible: false
product: MODEL1310110060#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110060#

metaR RE1531M
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110060#
name: RE1531
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110060#
product: MODEL1310110060#

metaR GALSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is described by: ECO:0000000
product: MODEL1310110060#
reversible: true
name: galactocerebroside intracellular transport
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#

metaR ANTHte
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
name: Transport of anthranilate
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
product: MODEL1310110060#

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
name: galactose-6-sulfate sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM 34dhpha c
name: (3,4-dihydroxyphenyl)acetate
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
boundary condition: false
is: CHEBI:17612
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01336

metaR GUACYC
type: Reaction
name: guanylate cyclase
is: SBO:0000176
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110060#
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/4.6.1.2
fast: false
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT

metaR S23T2g
is described by: ECO:0000000
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
fast: false
reactant: MODEL1310110060#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110060#
modifier: MODEL1310110060#
is: SBO:0000176
type: Reaction

metaM hs deg10 l
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 10
initial amount: NaN
is: CHEBI:15748
is: SBO:0000247
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
is: HMDB00127
boundary condition: false
constant: false
has only substance units: false

metaR RE0830C
type: Reaction
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
name: RE0830
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110060#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR NH4tp
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110060#
fast: false
name: ammonia peroxisomal transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110060#

metaR 10FTHFtm
reactant: MODEL1310110060#
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110060#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
product: MODEL1310110060#

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_73254233_2546_4bf9_8a0f_94cfe95fdc53
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: GGT1
boundary condition: true
is: P19440
constant: false
initial amount: NaN
is encoded by: hsa:2678
type: Species

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR RE2659R
is: SBO:0000176
name: RE2659
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000
product: MODEL1310110060#
type: Reaction
reversible: true
kinetic law: MODEL1310110060#
fast: false

metaR RE0344C
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110060#
name: RE0344
modifier: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110060#_8b4dd1ec_cd5e_489c_b4ff_a183cf6994c4
is: Q14032
has only substance units: false
initial concentration: NaN
is encoded by: hsa:570
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: BAAT
type: Species

metaM fald c
constant: false
has only substance units: false
name: formaldehyde
boundary condition: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01426
is: CHEBI:16842

metaM g6p c
is: CHEBI:61548
is: C00092
is: HMDB01401
name: D-Glucose 6-phosphate
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false

metaM sebcoa x
constant: false
name: sebacoylcoa
initial amount: NaN
is: HMDB04047
type: Species
has only substance units: false
is: SBO:0000247
is: C14143
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110060#_8b52e45a_0eae_4f10_85f8_5d6a254d7bfe
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P78382
type: Species
is encoded by: hsa:10559
name: SLC35A1

metaM CE2424 m
constant: false
boundary condition: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
has only substance units: false
type: Species
is: HMDB11123
is: SBO:0000247
is: CHEBI:28387
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
initial amount: NaN
initial concentration: 1.0

metaM crtsl r
name: cortisol
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17650
boundary condition: false
is: HMDB00063
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_0b830816_befe_4021_bc59_7aaa67f7e76f
is: B2RAT6
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:2592
is: SBO:0000252
name: GALT
type: Species

metaR r0911
reactant: MODEL1310110060#
kinetic law: MODEL1310110060#
name: Facilitated diffusion
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

metaR ADAe
type: Reaction
modifier: MODEL1310110060#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
kinetic law: MODEL1310110060#
name: Adenosine deaminase, extracellular
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.5.4.4
fast: false
reactant: MODEL1310110060#
is: SBO:0000176

metaM ha pre1 e
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN
constant: false
type: Species
name: hyaluronan biosynthesis, precursor 1
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:16126

metaM dad 2 e
is: CHEBI:17256
is: HMDB00101
has only substance units: false
initial concentration: 1.0
constant: false
name: 2-deoxyadenosine
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431

metaR URIK1
type: Reaction
reactant: MODEL1310110060#
is described by: ECO:0000269
modifier: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
is: SBO:0000176
reversible: false
name: uridine kinase (ATP:Uridine)
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110060#

metaR M13N2Tg
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.101
product: MODEL1310110060#
modifier: MODEL1310110060#
fast: false
kinetic law: MODEL1310110060#
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_0c8ddc8e_d400_4c82_81c9_99e703105c48
constant: false
is: SBO:0000252
initial concentration: NaN
name: AMY2B
initial amount: NaN
is: P19961
boundary condition: true
is encoded by: hsa:280
has only substance units: false
type: Species

metaR LYSOXp
reversible: false
kinetic law: MODEL1310110060#
is: SBO:0000176
product: MODEL1310110060#
name: L-lysine oxidase, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_7d13199a_30d0_4c08_bb9f_582f42ba20d7
is: P28331
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4719
name: NDUFS1

metaM ksii core4 pre7 g
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
constant: false
is: CHEBI:58053
is: C00130
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: SBO:0000247
is: HMDB00175
initial concentration: 1.0

metaR r0409
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is version of: http://identifiers.org/ec-code/3.2.1.10
fast: false
is: SBO:0000176
reversible: true

metaM CE2705 c
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:36781
name: quinonoid dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
constant: false
boundary condition: false

metaM thbpt c
has only substance units: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15372
initial concentration: 1.0
is: HMDB00027
constant: false
boundary condition: false
name: 5,6,7,8-tetrahydrobiopterin

metaR r0408
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110060#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_63d9da73_50e8_4015_b858_f72d3de5792e
boundary condition: true
has only substance units: false
is encoded by: hsa:4715
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9Y6M9
name: NDUFB9
type: Species

metaM 4mop c
is: SBO:0000247
is: CHEBI:17865
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial amount: NaN
is: HMDB00695
type: Species
boundary condition: false
has only substance units: false

metaR r0497
product: MODEL1310110060#
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reversible: true
modifier: MODEL1310110060#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110060#_021072ae_9a1e_4c31_a32c_2d7fc95cc691
name: DGAT1
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8694
is: O75907

metaR r0093
is described by: ECO:0000000
kinetic law: MODEL1310110060#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
fast: false
reversible: false
modifier: MODEL1310110060#
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
is version of: http://identifiers.org/ec-code/3.5.1.3
type: Reaction
reactant: MODEL1310110060#
product: MODEL1310110060#

metaM co2 x
has only substance units: false
is: SBO:0000247
name: carbon dioxide
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:16526
constant: false

metaM ha l
boundary condition: false
constant: false
is: CHEBI:16336
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
has only substance units: false
name: hyaluronan
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110060#_cbe27a03_1443_467d_84ca_02685c99eb89
constant: false
is: SBO:0000252
name: ACOT4
initial amount: NaN
is: Q8N9L9
type: Species
boundary condition: true
is encoded by: hsa:122970
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110060#_a2722663_3473_4e5f_a743_1c707f373b5f
has only substance units: false
constant: false
name: ACSS1
initial amount: NaN
is: Q9NUB1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:84532
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_a3c9786f_bea6_4227_b624_e0c8941849ba
is: P49753
type: Species
is encoded by: hsa:10965
initial amount: NaN
has only substance units: false
boundary condition: true
name: ACOT2
initial concentration: NaN
constant: false
is: SBO:0000252

metaM 2obut c
is: CHEBI:16763
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
name: 2-Oxobutanoate
is: HMDB00005
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C00109
constant: false

metaM itp n
is: HMDB00189
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
initial amount: NaN
name: ITP(3-)
is: CHEBI:57614
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_94c5f8e8_99f0_4d99_b649_b7c4fa289471
name: OGDHL
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55753
constant: false
has only substance units: false
initial concentration: NaN
is: Q9ULD0

http://identifiers.org/biomodels.db/MODEL1310110060#_31231353_eb72_43b6_b304_8bf177e6cfdd
constant: false
has only substance units: false
initial amount: NaN
is: P14672
is encoded by: hsa:6517
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC2A4

http://identifiers.org/biomodels.db/MODEL1310110060#_c6944a9e_f6ed_4f93_ba0c_cc5130be9277
is: P15954
has only substance units: false
type: Species
name: COX7C
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1350

http://identifiers.org/biomodels.db/MODEL1310110060#_adc3b251_2fe6_4a44_a7da_36b8fa197bdd
name: GALNT4
initial concentration: NaN
initial amount: NaN
is: Q8N4A0
constant: false
type: Species
is encoded by: hsa:8693
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r0139
reactant: MODEL1310110060#
product: MODEL1310110060#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
modifier: MODEL1310110060#
type: Reaction
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/2.3.2.2

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR r0407
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110060#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
fast: false
reactant: MODEL1310110060#
product: MODEL1310110060#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13

metaR RE1845C
modifier: MODEL1310110060#
is described by: ECO:0000000
product: MODEL1310110060#
name: RE1845
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110060#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is: SBO:0000176
reversible: true
reactant: MODEL1310110060#

metaM f1a l
type: Species
boundary condition: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
has only substance units: false
is: SBO:0000247
is: HMDB02917
is: CHEBI:17151
constant: false
initial amount: NaN
name: F1alpha
initial concentration: 1.0

metaR 4MOPt2im
is: SBO:0000185
product: MODEL1310110060#
reactant: MODEL1310110060#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
kinetic law: MODEL1310110060#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction
reversible: false

metaR r0913
is: SBO:0000185
kinetic law: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110060#
reactant: MODEL1310110060#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM dhcholestancoa x
is: SBO:0000247
has only substance units: false
is: HMDB02159
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial amount: NaN
is: CHEBI:15494
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

metaM ggn c
notes: FORMULA: C48H81O41X CHARGE: 0 INCHI: InChI=1/C6H11O5/c7-1-4-6(10)5(9)3(8)2-11-4/h2-10H,1H2/t3-,4+,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC02131
initial concentration: 1.0
is: CHEBI:57606
has only substance units: false
boundary condition: false
is: SBO:0000247
name: primed glycogenin (glycogenin-8[1,4-Glc])
initial amount: NaN
is: HMDB00267
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110060#_f0d6139b_3767_4628_8c4a_144b93c134aa
is encoded by: hsa:1329
has part: Q96KJ9
is encoded by: hsa:4512
has part: Q6YFQ2
is encoded by: hsa:1327
is encoded by: hsa:1349
has part: Q53YB7
has part: P09669
is encoded by: hsa:341947
is encoded by: hsa:1346
has only substance units: false
has part: Q02221
constant: false
is encoded by: hsa:170712
is encoded by: hsa:1340
is encoded by: hsa:1350
has part: P24311
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:4513
is encoded by: hsa:9167
has part: P20674
has part: Q53XN1
has part: Q8TF08
initial concentration: NaN
has part: Q7GXY8
has part: P14854
has part: P00414
is encoded by: hsa:1351
is: SBO:0000297
has part: Q7Z4L0
has part: P12074
has part: Q7GXZ8
is encoded by: hsa:1339
is encoded by: hsa:125965
initial amount: NaN
is encoded by: hsa:4514
is encoded by: hsa:84701
has part: P15954
is encoded by: hsa:9377
is encoded by: hsa:1337
is encoded by: hsa:1347
has part: Q6FGA0
has part: P24310
has part: H0UI06
boundary condition: true
is encoded by: hsa:1345
type: Species
has part: P13073

metaR THP2Ctp
reversible: true
product: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110060#
is described by: ECO:0000000
reactant: MODEL1310110060#
fast: false
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_762aa727_54d9_4244_a013_5ae54d0900a5
constant: false
is encoded by: hsa:92745
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q8WUX1
initial amount: NaN
name: SLC38A5
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110060#_327e24e2_347d_42b1_bd12_29fa2b38094c
type: Species
initial amount: NaN
name: ALDH2
is: P05091
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:217
is: SBO:0000252

metaR S3TASE1ly
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110060#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
reactant: MODEL1310110060#
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110060#
fast: false

metaR S6T11g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110060#
fast: false
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110060#
is: SBO:0000176
type: Reaction
product: MODEL1310110060#

http://identifiers.org/biomodels.db/MODEL1310110060#_33a12301_80d2_46da_ac0d_8462ce31cd67
initial concentration: NaN
is encoded by: hsa:374907
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q7Z7M8
type: Species
name: B3GNT8

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110060#_c79ed02b_a222_4000_a43d_641a9ce583c5
initial concentration: NaN
is encoded by: hsa:23761
name: PISD
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q9UG56

http://identifiers.org/biomodels.db/MODEL1310110060#_56f2c319_1dc9_4ab0_9a83_199b3d62994d
name: SUCLG2
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8801
is: Q96I99
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaR HPYRDC
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
fast: false
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
type: Reaction
name: hydroxypyruvate decarboxylase
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110060#

metaR S6TASE18ly
modifier: MODEL1310110060#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110060#
reactant: MODEL1310110060#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false

metaM 12ppd S c
boundary condition: false
is: HMDB06213
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:29002
constant: false
name: (S)-propane-1,2-diol
initial concentration: 1.0
type: Species
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110060#_39539b4b_d12e_4326_89d3_73050b6e71b8
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3098
is: SBO:0000252
is: P19367
name: HK1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110060#_6079028a_c5a0_4077_9188_2315cf7b0029
is encoded by: hsa:4540
is encoded by: hsa:4706
boundary condition: true
is encoded by: hsa:4541
is encoded by: hsa:4539
is encoded by: hsa:4718
has part: Q9Y6M9
is encoded by: hsa:4697
is encoded by: hsa:4535
constant: false
has part: O43674
is encoded by: hsa:4713
has part: F8VQS7
is encoded by: hsa:4711
has part: O00217
is encoded by: hsa:4731
is encoded by: hsa:51079
has part: O43677
has part: O14561
has part: P17568
is encoded by: hsa:4694
is encoded by: hsa:7991
has part: Q6IBC4
type: Species
initial concentration: NaN
has part: Q13454
has part: H7C5B8
is encoded by: hsa:4725
is encoded by: hsa:4723
has part: O95299
is encoded by: hsa:4715
has part: O95169
is encoded by: hsa:4707
is encoded by: hsa:4702
has part: Q7GXZ4
is encoded by: hsa:55967
is encoded by: hsa:4700
has part: O43181
is encoded by: hsa:4720
is encoded by: hsa:4719
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: P56556
is encoded by: hsa:4536
is encoded by: hsa:4714
is encoded by: hsa:4712
has part: Q16718
has part: O95139
has part: Q7GXY9
has part: Q85KV6
is encoded by: hsa:4537
has part: C9JT23
has only substance units: false
is encoded by: hsa:4695
has part: O75489
has part: P03905
has part: B7Z792
has part: P03897
is encoded by: hsa:4704
is encoded by: hsa:4726
initial amount: NaN
is encoded by: hsa:4716
is encoded by: hsa:4708
is encoded by: hsa:4728
has part: O75438
has part: Q9P0J0
is encoded by: hsa:4701
has part: Q6IB80
has part: A8K761
has part: Q6FG42
has part: O95168
has part: O43678
has part: P03915
has part: Q6IBA0
is encoded by: hsa:126328
has part: B1AM93
is encoded by: hsa:4538
is encoded by: hsa:4698
is encoded by: hsa:4717
has part: Q549M5
is encoded by: hsa:4696

metaM dad 2 c
is: CHEBI:17256
name: 2-deoxyadenosine
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00101
constant: false
is: SBO:0000247
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
type: Species
initial concentration: 1.0

metaR r1609
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110060#
product: MODEL1310110060#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110060#

metaM m7mpdol U r
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
is: CHEBI:37636
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110060#_3950bbe5_7e7e_4c8c_9e5d_d275e3645317
is encoded by: hsa:219
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: P30837
constant: false
is: SBO:0000252
name: ALDH1B1
has only substance units: false

metaM citr L m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
initial amount: NaN
type: Species
name: L-citrulline
has only substance units: false
is: CHEBI:16349
constant: false

metaR 34DHXMANDACOX NADP
fast: false
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110060#
modifier: MODEL1310110060#
product: MODEL1310110060#

metaM cdp m
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01546
is: SBO:0000247
initial concentration: 1.0
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
is: CHEBI:58069

metaR FACOAL181i
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269
reactant: MODEL1310110060#
name: C181 fatty acid activation
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110060#
fast: false
modifier: MODEL1310110060#
kinetic law: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110060#_1f24a23b_706b_4180_bb58_b784b4b07a79
is: SBO:0000252
name: PNPO
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:55163
type: Species
is: Q9NVS9
boundary condition: true

metaR r1607
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110060#
reversible: true
product: MODEL1310110060#
is: SBO:0000185
kinetic law: MODEL1310110060#

metaR HEX1
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.1
product: MODEL1310110060#
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
reversible: false
kinetic law: MODEL1310110060#
is described by: ECO:0000134
reactant: MODEL1310110060#
modifier: MODEL1310110060#
type: Reaction
name: hexokinase (D-glucose:ATP)

metaR r0242
kinetic law: MODEL1310110060#
fast: false
is: SBO:0000176
reactant: MODEL1310110060#
is version of: http://identifiers.org/ec-code/6.2.1.1
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
modifier: MODEL1310110060#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
reversible: true
type: Reaction
product: MODEL1310110060#
is described by: ECO:0000000

metaM hspg l
name: heparan sulfate proteoglycan
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
boundary condition: false
is: HMDB01993
type: Species
constant: false
is: CHEBI:17899
has only substance units: false

metaM arab L e
is: SBO:0000247
has only substance units: false
name: L-arabinose
constant: false
initial concentration: 1.0
is: CHEBI:30849
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0
type: Species
is: HMDB00646