metaR G5SDym
kinetic law: MODEL1310110059#
name: glutamate-5-semialdehyde dehydrogenase (m)
reactant: MODEL1310110059#
is described by: ECO:0000254
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.41
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
fast: false
is: SBO:0000176
product: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#

metaR AKR1C41
is version of: http://identifiers.org/ec-code/1.1.1.225
reversible: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
fast: false
type: Reaction
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_a9ce7e99_275b_4cdb_b6db_9f1ad9f36220
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
has part: Q6FIH7
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:516
type: Species
has only substance units: false
initial concentration: NaN

metaR FAOXC184C163x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR 6DHFtl
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
product: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#
name: 6-glutamyl-DHF transport, lysosomal
reversible: false
reactant: MODEL1310110059#

metaM o2 e
initial concentration: 1.0
boundary condition: false
name: O2
type: Species
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
constant: false
initial amount: NaN
has only substance units: false
is: C00007
is: HMDB01377

metaM ksi pre27 g
boundary condition: false
initial amount: NaN
is: C00130
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 27
constant: false
type: Species
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: HMDB00175
is: SBO:0000247

metaM pi m
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
is: CHEBI:43474
constant: false
is: C00009
initial amount: NaN
is: HMDB00973
boundary condition: false
name: hydrogenphosphate
has only substance units: false
type: Species

metaR AMPDA
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.6
kinetic law: MODEL1310110059#
type: Reaction
name: Adenosine monophosphate deaminase
is described by: ECO:0000269
modifier: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
reversible: false
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_7c3c4b11_50a2_487b_b490_b81802b010cb
initial amount: NaN
type: Species
name: LHPP
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:64077
constant: false
boundary condition: true
is: Q9H008
has only substance units: false

metaR CYSTGL
notes: GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:10727430,PMID:15189131 NOTES:NCD
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false
name: cystathionine g-lyase
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.4.1.1

metaR M16NTg
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reversible: false
product: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.143
fast: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#

metaR r2018
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110059#
type: Reaction

metaR SUBERCACT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_bd4119b2_b821_4fa9_825d_2724210fd4f4
initial amount: NaN
has only substance units: false
is: B7Z3U6
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:476
boundary condition: true
name: ATP1A1
type: Species

metaR NADHtpu
is: SBO:0000185
reactant: MODEL1310110059#
name: NADH transporter, peroxisome
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
product: MODEL1310110059#

metaM hco3 m
initial amount: NaN
is: CHEBI:17544
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
name: Bicarbonate
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
is: HMDB00595

metaM arg L c
is: HMDB00517
boundary condition: false
initial concentration: 1.0
is: CHEBI:32682
constant: false
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: L-argininium(1+)

metaM hom L c
initial amount: NaN
is: HMDB00719
name: L-homoserine
type: Species
is: CHEBI:15699
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
boundary condition: false

metaR DOLPMT3 Uer
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000176
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.260
modifier: MODEL1310110059#
is described by: ECO:0000000
fast: false

metaM pi l
has only substance units: false
type: Species
is: CHEBI:43474
is: HMDB00973
boundary condition: false
name: hydrogenphosphate
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_75c2adc4_b8d9_4e75_9afb_567cc4b446f3
is: SBO:0000297
boundary condition: true
type: Species
has part: P53597
initial amount: NaN
is encoded by: hsa:8801
has part: Q96I99
constant: false
name: SUCLG2:SUCLG1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8802

metaR FAOXC61x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaR LDH D
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
name: D-lactate dehydrogenase
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.2.4
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110059#

metaR CSBPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
type: Reaction
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
product: MODEL1310110059#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#

metaR r0579
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110059#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.19
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110059#
fast: false

metaR r0163
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873,PMID:3207422 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_04fa580c_2aac_43a4_9b66_0f34c4ef98af
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:498
is: A8K092
initial amount: NaN
name: ATP5A1

metaR r1106
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110059#
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
fast: false

metaR TETPENT6COAtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
product: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
name: fatty acid intracellular transport
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185

metaR RE0344C
type: Reaction
reversible: true
modifier: MODEL1310110059#
name: RE0344
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reactant: MODEL1310110059#
is described by: ECO:0000000

metaR FAOXC102C101m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR ACRNtm
is: SBO:0000185
name: O-acetylcarnintine transport into mitochondria via diffusion
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD
kinetic law: MODEL1310110059#
reversible: false
is described by: ECO:0000269

metaM dhor S c
boundary condition: false
constant: false
is: SBO:0000247
name: (S)-dihydroorotate
is: CHEBI:30864
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
has only substance units: false
type: Species
is: HMDB03349

metaR SIAASE4ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
fast: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110059#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110059#

metaR FAOXC143C123x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_f50b5de3_6635_404f_8bab_9cd1d44b6673
constant: false
is encoded by: hsa:55753
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: OGDHL
boundary condition: true
type: Species
is: Q9ULD0

metaM hs deg23 l
notes: FORMULA: C31H49NO29S CHARGE: -2
type: Species
is: CHEBI:21338
initial concentration: 1.0
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false
initial amount: NaN
is: HMDB02704
boundary condition: false
is: SBO:0000247
constant: false

metaM 5hoxindoa c
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00763
constant: false
is: CHEBI:27823
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
initial concentration: 1.0
type: Species
name: 5-Hydroxyindoleacetate
initial amount: NaN

metaM HC01115 c
constant: false
has only substance units: false
name: NeuNGc
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
type: Species
is: CHEBI:29025
initial amount: NaN

metaR r0166
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR G14T8g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR RNDR4
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
name: ribonucleoside-diphosphate reductase (UDP)
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110059#
is described by: ECO:0000254

metaM ksi deg26 l
is: CHEBI:58343
boundary condition: false
is: HMDB00061
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 26
is: SBO:0000247
notes: FORMULA: C110H179N7O93S4 CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110059#_44afc4fa_54c9_4115_9752_bda858726aba
constant: false
is encoded by: hsa:8883
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: A8MU28
name: NAE1
initial concentration: NaN
initial amount: NaN

metaM ksi deg35 l
constant: false
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 35
is: HMDB00143
initial amount: NaN
type: Species
is: CHEBI:12936
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC24C22x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Fatty acid beta oxidation(C24-->C22)x
type: Reaction

metaR INSTt2r
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: inositol transport in via proton symport
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
type: Reaction

metaR ALAGLYexR
reactant: MODEL1310110059#
name: L-alanine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110059#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000304
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_7aa47057_8c76_4eef_964c_98350074ee0f
initial concentration: NaN
boundary condition: true
name: FOLR1
is encoded by: hsa:2348
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM hom L e
initial amount: NaN
is: HMDB00719
constant: false
type: Species
is: SBO:0000247
is: CHEBI:15699
name: L-homoserine
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
boundary condition: false

metaR FAOXTC101TC102m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaR 6DHFtm
kinetic law: MODEL1310110059#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
is described by: ECO:0000000
name: 6-glutamyl-DHF transport,m mitochondrial
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#

metaM arg L e
has only substance units: false
name: L-argininium(1+)
boundary condition: false
initial concentration: 1.0
is: CHEBI:32682
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517

http://identifiers.org/biomodels.db/MODEL1310110059#_65796e91_d334_455d_8827_f6ba00630010
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:R33828
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: _R33828_1_c

http://identifiers.org/biomodels.db/MODEL1310110059#_8d54a5e2_f2f5_438a_bd72_824dc35fb18e
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:1723
is: Q02127
is: SBO:0000252
name: DHODH
initial concentration: NaN
initial amount: NaN

metaR RE1796R
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
reversible: true
fast: false
product: MODEL1310110059#
name: RE1796

http://identifiers.org/biomodels.db/MODEL1310110059#_980b5cb9_2668_48b6_a3ae_ee08ea529c45
initial amount: NaN
has only substance units: false
type: Species
name: LDHD
is: Q86WU2
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:197257

http://identifiers.org/biomodels.db/MODEL1310110059#_f12ba68a_8c25_448a_b91d_ba09d82129e6
constant: false
is: O76062
is: SBO:0000252
initial concentration: NaN
type: Species
name: TM7SF2
boundary condition: true
has only substance units: false
is encoded by: hsa:7108
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_d759ae0e_5b0b_46a0_bdf5_d6134cba7201
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SUCLA2
constant: false
is: E5KS60
is encoded by: hsa:8803

metaR SBTD D2
name: D-sorbitol dehydrogenase (D-fructose producing)
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.14
fast: false
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
reversible: false
is described by: ECO:0000000
type: Reaction

metaR r0463
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
reversible: true
fast: false
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110059#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10

metaR VALTAm
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
fast: false
reversible: true
name: valine transaminase, mitochondiral
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110059#
is described by: ECO:0000269
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_5bd9fc4e_4ea6_4282_9532_5aa3b8c199e9
name: HSD3B1
is encoded by: hsa:3283
initial concentration: NaN
is: P14060
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaR r2346
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
fast: false

metaM thf e
is: HMDB01846
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: CHEBI:57453
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
boundary condition: false

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaM leuleu e
constant: false
type: Species
is: SBO:0000247
name: Leucylleucine
notes: FORMULA: C12H24N2O3 CHARGE: 0
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/94244
boundary condition: false

metaM ksi deg25 l
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
name: keratan sulfate I, degradation product 25
is: HMDB00812
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16953
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_22f69674_199a_4991_b608_3c94ed58cd21
has only substance units: false
boundary condition: true
is: SBO:0000252
name: IDH1
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: O75874
is encoded by: hsa:3417

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
product: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.48
fast: false
reversible: true
type: Reaction

metaM zymst r
name: zymosterol
is: CHEBI:18252
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: HMDB06271
is: SBO:0000247
has only substance units: false

metaM sprm c
type: Species
is: HMDB01256
name: spermine(4+)
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
initial concentration: 1.0
is: CHEBI:45725

metaM ksi deg38 l
constant: false
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 38
type: Species

metaR LACLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
name: Lactate transport
is described by: ECO:0000134
product: MODEL1310110059#
is: SBO:0000185

metaM acgal l
name: N-acetyl-D-galactosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00212
has only substance units: false
is: CHEBI:28037
is: SBO:0000247
type: Species
initial amount: NaN

metaM CE1944 c
name: 1-pyrrolinium
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: CHEBI:36781
initial concentration: 1.0
has only substance units: false

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM 2ddecdicoa x
initial amount: NaN
boundary condition: false
type: Species
is: C05279
initial concentration: 1.0
constant: false
is: HMDB11123
name: 2,6-dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_634ec12c_64ef_4b42_a7fa_1e649093b897
is: H0YMZ7
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: PDE8A
initial concentration: NaN
is encoded by: hsa:5151
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_69f289aa_f8f4_43b9_a8be_0d71a21c2885
is: C9JFZ1
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:8867
name: SYNJ1
type: Species

metaM digalside hs c
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8383
boundary condition: false
constant: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
name: Digalactosylceramide
initial concentration: 1.0
is: SBO:0000247
is: C06126
has only substance units: false

metaM o2 c
is: CHEBI:15379
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
name: O2
constant: false
is: C00007
is: HMDB01377
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR GALASE12ly
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
type: Reaction
product: MODEL1310110059#

metaR r0578
modifier: MODEL1310110059#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110059#
type: Reaction
reversible: true
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR GASNASEly
reversible: false
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.26
name: glycosylasparaginase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
modifier: MODEL1310110059#

metaR G14T18g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
type: Reaction
modifier: MODEL1310110059#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM s7p c
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
type: Species
boundary condition: false
initial concentration: 1.0
is: C05382
is: SBO:0000247
name: Sedoheptulose 7-phosphate
initial amount: NaN
is: HMDB01068
has only substance units: false
is: CHEBI:57483
constant: false

metaR FAOXC226205m
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110059#
fast: false
reversible: false
name: Beta oxidation of long chain fatty acid
product: MODEL1310110059#
is described by: ECO:0000000

metaM 3ddcrn c
notes: FORMULA: C19H37NO5 CHARGE: 0
constant: false
is: SBO:0000247
is: HMDB00623
boundary condition: false
name: 3-hydroxydodecanoylcarnitine
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaM dsmsterol r
type: Species
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
is: SBO:0000247
is: HMDB02719
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17737
boundary condition: false
name: desmosterol

http://identifiers.org/biomodels.db/MODEL1310110059#_3d18f42b_b95c_4a45_b60c_f74998d8334b
is: SBO:0000252
name: ND4
initial concentration: NaN
type: Species
is: P03905
is encoded by: hsa:4538
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_12e0f9c1_5a7a_431c_8182_94b4a31ff0a6
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9BQG2
boundary condition: true
has only substance units: false
is encoded by: hsa:83594
constant: false
name: NUDT12
initial amount: NaN

metaR DMNONCRNCPT2
product: MODEL1310110059#
type: Reaction
name: DMNONCRNCPT2
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#

metaR S6T4g
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110059#_dadfc672_1f9f_4b9c_9eb8_3745911f8176
is: SBO:0000252
initial amount: NaN
is: P21108
constant: false
initial concentration: NaN
boundary condition: true
name: PRPS1L1
type: Species
is encoded by: hsa:221823
has only substance units: false

metaR BTNDm
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
reversible: false
name: biotinidase (biotin), mitochondrial
kinetic law: MODEL1310110059#

metaM thf c
has only substance units: false
initial concentration: 1.0
is: HMDB01846
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453
constant: false
name: 5,6,7,8-Tetrahydrofolate
boundary condition: false
is: C00101

metaM sprm e
is: HMDB01256
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
name: spermine(4+)
boundary condition: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
has only substance units: false
is: CHEBI:45725
initial concentration: 1.0

metaM adp e
constant: false
is: HMDB01341
is: SBO:0000247
boundary condition: false
is: CHEBI:456216
name: ADP(3-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species
initial concentration: 1.0

metaR r0464
product: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_06bd6d4a_7c2d_4e50_bad5_2d6181894dab
name: MTMR2
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: A6NN98
constant: false
type: Species
has only substance units: false
is encoded by: hsa:8898
is: SBO:0000252

metaM nadph x
has only substance units: false
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
initial amount: NaN
boundary condition: false
is: CHEBI:57783
initial concentration: 1.0
is: HMDB00221
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_1b15efee_0243_4c91_a9fd_9a61c2a0688a
is: P36551
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: CPOX
type: Species
has only substance units: false
is encoded by: hsa:1371
constant: false

metaR r2347
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110059#

metaM dcholcoa x
is: HMDB06292
initial amount: NaN
constant: false
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
has only substance units: false
is: CHEBI:28701
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

http://identifiers.org/biomodels.db/MODEL1310110059#_587c5b2b_7701_4f3d_98da_4307e43dba05
is encoded by: hsa:AL048840
initial concentration: NaN
name: _AL048840_1_c
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_b07543e9_483c_434e_bb84_4d39aa3d200b
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:10935
is: SBO:0000252
name: PRDX3
boundary condition: true
initial concentration: NaN
constant: false
is: P30048

metaR PHYCBOXL
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000212
reactant: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
name: L-Phenylalanine carboxy-lyase
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_e2893fd0_765d_4a12_b7ac_4fe635bf37f9
name: IDH3A:IDH3B:IDH3G
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:3420
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000297

metaM pi n
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
has only substance units: false
is: CHEBI:43474
is: HMDB00973
constant: false

metaR FACOAL150
product: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
name: fatty-acid--CoA ligase
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false

metaM adp r
is: HMDB01341
initial amount: NaN
boundary condition: false
has only substance units: false
name: ADP(3-)
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM dhap x
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
is: HMDB01473
is: C00111
type: Species
is: CHEBI:57642
initial concentration: 1.0
constant: false
name: Dihydroxyacetone phosphate

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM amp c
initial amount: NaN
is: HMDB00045
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
boundary condition: false
type: Species
is: C00020
name: AMP
is: CHEBI:3322
is: SBO:0000247

metaR DDECCRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaR FAOXC18280m
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
is described by: ECO:0000000
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
modifier: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#

metaM nadph m
constant: false
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
initial amount: NaN
is: C00005
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
type: Species
is: HMDB00221

metaM decdicrn e
has only substance units: false
initial amount: NaN
is: HMDB13325
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: decadienoyl carnitine
notes: FORMULA: C17H29NO4 CHARGE: 0
initial concentration: 1.0

metaM udpg c
is: CHEBI:58367
boundary condition: false
name: UDPglucose
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: C00029
is: HMDB00286
constant: false

metaR PGISr
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/5.3.99.4
name: Prostaglandin I2 synthase
type: Reaction
modifier: MODEL1310110059#
reversible: true
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ

metaR H2Otly
product: MODEL1310110059#
name: H2O transport, lysosomal
fast: false
reactant: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110059#

metaM thcrm hs g
is: SBO:0000247
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
name: trihexosyl ceramide
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:24636

metaM hs deg10 l
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: heparan sulfate, degradation product 10
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
type: Species
is: HMDB00127
initial concentration: 1.0
is: CHEBI:15748
initial amount: NaN

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM 2dr1p c
type: Species
name: 2-Deoxy-D-ribose 1-phosphate
initial concentration: 1.0
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
constant: false
initial amount: NaN
is: HMDB01351
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58576
is: C00672

metaM c5dc e
is: HMDB13130
notes: FORMULA: C12H21NO6 CHARGE: 0
type: Species
is: SBO:0000247
name: glutaryl carnitine
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN

metaM 3octdeccrn e
boundary condition: false
is: HMDB13336
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C25H49NO5 CHARGE: 0
name: 3-hydroxyoctadecanoyl carnitine

metaM q10h2 e
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false
name: Ubiquinol-10
type: Species
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
initial concentration: 1.0
constant: false
initial amount: NaN

metaR FAOXC226205x
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110059#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
product: MODEL1310110059#

metaR EX c81crn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR KSII CORE4tly
kinetic law: MODEL1310110059#
name: keratan sulfate II (core 4) transport, extracellular to lysosome
is: SBO:0000185
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000

metaR FAOXC2452256x
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
name: Beta oxidation of long chain fatty acid
fast: false
is described by: ECO:0000000
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false

metaM dcholcoa r
is: HMDB06292
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
type: Species
is: CHEBI:28701

metaR r0571
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.8
fast: false
reactant: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110059#
product: MODEL1310110059#
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_7b047944_21ae_4f79_b3cd_6cff4ac6b017
has only substance units: false
boundary condition: true
is encoded by: hsa:3636
name: INPPL1
is: SBO:0000252
constant: false
type: Species
is: O15357
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_7aaa37ce_4f88_452d_9457_99dbdcc91ab5
is encoded by: hsa:7358
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: UGDH
is: O60701

metaR LDH L
type: Reaction
name: L-lactate dehydrogenase
kinetic law: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
fast: false

metaR G6Pter
type: Reaction
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
fast: false
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
is described by: ECO:0000269
reversible: true

metaM amp e
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00045
initial concentration: 1.0
name: AMP
is: C00020
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
initial amount: NaN
has only substance units: false

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_6b1bf222_bca6_4b92_b897_b89e82041220
has only substance units: false
is encoded by: hsa:6818
initial concentration: NaN
is: SBO:0000252
type: Species
is: P50224
initial amount: NaN
constant: false
name: SULT1A3
boundary condition: true

metaR CYSGLNNaEx
is described by: ECO:0000269
modifier: MODEL1310110059#
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
is: SBO:0000185
reversible: false
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#

metaR NRPPHRt4 2 r
is described by: ECO:0000269
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000185
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
type: Reaction
name: Norepinephrine reversible transport in via sodium symport (1:2)
product: MODEL1310110059#

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM decdicrn c
initial amount: NaN
is: HMDB13325
constant: false
type: Species
name: decadienoyl carnitine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C17H29NO4 CHARGE: 0
initial concentration: 1.0
has only substance units: false

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_257a9b19_56ae_49f8_9961_9bae8c8b4482
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:43
name: ACHE

metaM ocdca c
initial concentration: 1.0
is: HMDB00827
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: CHEBI:25629
boundary condition: false
constant: false
type: Species
name: stearate

http://identifiers.org/biomodels.db/MODEL1310110059#_0423d3c7_dac6_428b_878f_6e63f57971a6
has only substance units: false
is: SBO:0000252
name: ND3
initial concentration: NaN
is encoded by: hsa:4537
is: P03897
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaM 3octdeccrn c
name: 3-hydroxyoctadecanoyl carnitine
constant: false
notes: FORMULA: C25H49NO5 CHARGE: 0
initial concentration: 1.0
is: HMDB13336
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

metaM q10h2 c
constant: false
initial amount: NaN
boundary condition: false
name: Ubiquinol-10
has only substance units: false
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
is: HMDB13111

metaM c5dc c
is: HMDB13130
notes: FORMULA: C12H21NO6 CHARGE: 0
name: glutaryl carnitine
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

metaM ach n
type: Species
is: SBO:0000247
is: HMDB00895
is: CHEBI:15355
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: acetylcholine
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaR ALDD2x
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetaldehyde, NAD)
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110059#
product: MODEL1310110059#

metaM adrncrn m
name: Adrenyl carnitine
is: C00318
boundary condition: false
notes: FORMULA: C29H49NO4 CHARGE: 0
initial concentration: 1.0
is: HMDB00062
has only substance units: false
type: Species
is: CHEBI:16347
constant: false
is: SBO:0000247
initial amount: NaN

metaR DCSPTN1t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110059#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#

metaR MI134PP
name: inositol-1,3,4-trisphosphate 1-phosphatase
modifier: MODEL1310110059#
reversible: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.57
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110059#

metaR HEXCOAACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

metaM 10fthf m
type: Species
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 10-formyltetrahydrofolate(2-)
is: HMDB00972
constant: false
has only substance units: false
is: CHEBI:57454

metaM pi r
is: C00009
name: hydrogenphosphate
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00973
type: Species
is: CHEBI:43474
is: SBO:0000247

metaM phyt2ohcoa x
is: SBO:0000247
is: CHEBI:57334
initial amount: NaN
has only substance units: false
is: HMDB01295
name: 2-hydroxyphytanoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
type: Species
boundary condition: false
constant: false

metaM aicar c
constant: false
has only substance units: false
is: HMDB01517
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: C04677
type: Species
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR PSDm hs
is version of: http://identifiers.org/ec-code/4.1.1.65
is: SBO:0000176
modifier: MODEL1310110059#
is described by: ECO:0000269
reactant: MODEL1310110059#
product: MODEL1310110059#
name: Phosphatidylserine decarboxylase
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
kinetic law: MODEL1310110059#
fast: false
type: Reaction
reversible: false

metaR FAOXC61m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_9632aaeb_1cba_4c7c_9d47_7919447c0307
initial concentration: NaN
is encoded by: hsa:8706
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: O75752
name: B3GALNT1
has only substance units: false

metaM HC02205 c
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
name: prostaglandin-b2
initial concentration: 1.0
is: CHEBI:28099
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR DURIPP
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
reversible: true
name: deoxyuridine phosphorylase
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.3

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR SPC HSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
fast: false
type: Reaction
is: SBO:0000185
name: sphingosylphosphorylcholine transport (diffusion)

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR HEX1
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
name: hexokinase (D-glucose:ATP)

metaM ocdca e
boundary condition: false
initial amount: NaN
name: octadecanoate (n-C18:0)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
has only substance units: false
type: Species
constant: false
is: C01530
is: CHEBI:25629
is: HMDB00827

metaR RNDR1
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110059#
is described by: ECO:0000254
product: MODEL1310110059#
reversible: false
is: SBO:0000176
type: Reaction
name: ribonucleoside-diphosphate reductase (ADP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaM adp n
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01341
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
name: ADP(3-)
is: CHEBI:456216

metaM ocdececrn c
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: HMDB06351
name: 11-octadecenoyl carnitine
initial amount: NaN
constant: false

metaM prgnlones c
constant: false
initial amount: NaN
is: HMDB00774
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: pregnenolone sulfate
is: CHEBI:35420
boundary condition: false
type: Species

metaM pi x
name: hydrogenphosphate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00973

metaM thf m
initial concentration: 1.0
is: CHEBI:57453
is: SBO:0000247
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB01846
name: 5,6,7,8-Tetrahydrofolate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_0da2b93f_c40b_47eb_aaad_3542aaefefdd
is encoded by: hsa:2876
type: Species
initial concentration: NaN
name: GPX1
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: P07203

metaM c4crn c
is: HMDB02013
notes: FORMULA: C11H21NO4 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: butyryl carnitine
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
is: C02862
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_7df59f6a_080e_48f0_b444_ee2174d14d32
initial amount: NaN
boundary condition: true
is: Q6IBA0
type: Species
is: SBO:0000252
is encoded by: hsa:4725
initial concentration: NaN
constant: false
has only substance units: false
name: NDUFS5

metaM chsterol e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: CHEBI:16113
boundary condition: false
name: cholesterol
is: HMDB00067

http://identifiers.org/biomodels.db/MODEL1310110059#_2d33590a_7f00_4420_a251_f45abd9c821a
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: O00624
is encoded by: hsa:10246
name: SLC17A2
has only substance units: false

metaM arachd e
name: arachidonate
is: CHEBI:32395
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01043

metaM digalside hs l
is: C06126
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
name: Digalactosylceramide
has only substance units: false
is: http://identifiers.org/pubchem.compound/8383
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaM nadph r
type: Species
is: C00005
initial amount: NaN
boundary condition: false
is: CHEBI:57783
constant: false
has only substance units: false
is: HMDB00221
is: SBO:0000247
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaM aicar e
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial amount: NaN
is: HMDB01517
constant: false
is: C04677
initial concentration: 1.0
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
type: Species
is: CHEBI:58475
boundary condition: false
has only substance units: false

metaR HTDCRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaM arachd c
type: Species
has only substance units: false
name: arachidonate
boundary condition: false
initial concentration: 1.0
is: HMDB01043
is: CHEBI:32395
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110059#_005b441b_8bc7_4879_a619_e522d10e97b7
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:27034
type: Species
has only substance units: false
initial concentration: NaN
name: ACAD8
is: Q6ZWP6

metaM HC02205 e
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: CHEBI:28099
name: prostaglandin-b2
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false

metaR OCDCEAtr
is: SBO:0000185
reactant: MODEL1310110059#
fast: false
product: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: fatty acid transport via diffusion
type: Reaction

metaR LNELDCCPT1
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110059#
is described by: ECO:0000269
reactant: MODEL1310110059#

metaM thf l
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
has only substance units: false
type: Species
is: CHEBI:57453
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: HMDB01846
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_131e9bae_d800_4b0e_8c30_cd5a895b3584
is: O95907
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: SLC16A8
is encoded by: hsa:23539

metaR r0570
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
reactant: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is version of: http://identifiers.org/ec-code/6.3.3.2
type: Reaction
product: MODEL1310110059#
fast: false
is: SBO:0000176
modifier: MODEL1310110059#

metaR HEX4
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
name: hexokinase (D-mannose:ATP)
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.1.2
modifier: MODEL1310110059#
is described by: ECO:0000304

metaM arachdcoa c
initial amount: NaN
is: SBO:0000247
is: CHEBI:57368
type: Species
initial concentration: 1.0
name: arachidonoyl-CoA(4-)
is: HMDB06523
constant: false
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
boundary condition: false

metaR DURAD
name: dihydrouracil dehydrogenase (NADP)
modifier: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2
is described by: ECO:0000269
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_f325928d_b231_4a3a_be3b_bdfb4a83a08c
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7084
name: TK2
constant: false
is: SBO:0000252
initial amount: NaN
is: O00142
type: Species

metaR ADRNCRNt
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#

metaR DOLPMT3 Ler
kinetic law: MODEL1310110059#
fast: false
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110059#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.260
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_08d3d41e_5074_46ad_b71a_c763c040780e
is encoded by: hsa:953
initial amount: NaN
has only substance units: false
name: ENTPD1
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: Q86VV3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_431ae0e0_4d17_4188_8623_50605eedbe55
initial amount: NaN
has only substance units: false
is encoded by: hsa:56606
name: SLC2A9
boundary condition: true
type: Species
is: Q9NRM0
constant: false
initial concentration: NaN
is: SBO:0000252

metaR DDPGAm
fast: false
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is described by: ECO:0000000
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR PROSTGE2t
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110059#

metaR NACHEX1ly
modifier: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110059#
reversible: false
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110059#
is: SBO:0000176

metaR PRAGSr
type: Reaction
reversible: true
modifier: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.2
name: phosphoribosylglycinamide synthase
reactant: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR LNELDCCPT2
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110059#
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110059#_18a8ae97_b6d0_44c5_b623_0ad74f1bab7b
has only substance units: false
is: Q9NY65
name: EHHADH
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:1962

metaR GALASE11ly
is: SBO:0000176
product: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_1d84f32d_2ada_455b_8a18_3466edb3494c
constant: false
is encoded by: hsa:4696
initial amount: NaN
name: NDUFA3
is: O95167
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaR C101CPT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaM ksi deg10 l
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
is: CHEBI:16953
is: HMDB00812
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 10
has only substance units: false
constant: false
initial amount: NaN

metaM adp m
initial amount: NaN
has only substance units: false
type: Species
name: ADP
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3310
initial concentration: 1.0
is: C00008
boundary condition: false
is: CHEBI:456216
constant: false
is: HMDB01341

metaR ABUTD
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: Aminobutyraldehyde dehydrogenase
product: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
modifier: MODEL1310110059#
is: SBO:0000176

metaM chsterol c
initial concentration: 1.0
has only substance units: false
is: HMDB00067
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
constant: false
name: cholesterol
boundary condition: false
is: CHEBI:16113

metaR DRPA
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
name: deoxyribose-phosphate aldolase
kinetic law: MODEL1310110059#
reversible: false

metaR G6PDA
name: glucosamine-6-phosphate deaminase
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000176
product: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/3.5.99.6
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1b090093_b97d_4fd3_a7ee_2cec7620742a
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:5625
name: PRODH
initial amount: NaN
boundary condition: true
is: O43272
initial concentration: NaN

metaR FAOXC143C123m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_70de61fc_ff11_4737_80da_268117f74db1
type: Species
name: PYCR2
initial amount: NaN
boundary condition: true
is: Q96C36
initial concentration: NaN
is encoded by: hsa:29920
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_de24f8ff_45c2_47a3_8457_6842f0ffdfcf
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5148
has part: P18545
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
type: Species
is encoded by: hsa:5147
boundary condition: true
initial amount: NaN
has part: O43924
is: SBO:0000297

metaM HC01410 m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
constant: false
is: CHEBI:28706
is: SBO:0000247
name: (2E)-Hexenoyl-CoA
has only substance units: false

metaM hexdiac c
initial amount: NaN
boundary condition: false
is: C08260
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C16H28O4 CHARGE: -2
name: hexadecanediocacid
constant: false
has only substance units: false
is: HMDB00672

metaM c8crn e
is: HMDB00791
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: octanoyl carnitine
has only substance units: false
notes: FORMULA: C15H29NO4 CHARGE: 0
type: Species
is: C02838
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_0cde4e07_4b52_4e83_854d_ba3c549555df
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:3157
name: HMGCS1
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaM amp m
has only substance units: false
type: Species
boundary condition: false
is: HMDB00045
constant: false
is: CHEBI:456215
is: SBO:0000247
name: AMP(2-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaM ppi e
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
is: HMDB00250
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Diphosphate
constant: false
is: C00013
has only substance units: false
is: CHEBI:33019

http://identifiers.org/biomodels.db/MODEL1310110059#_5f312975_6159_4f7c_8a27_fa6a4cc73999
boundary condition: true
is encoded by: hsa:788
is: SBO:0000252
name: SLC25A20
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: O43772

metaR ANTHte
is: SBO:0000185
fast: false
is described by: ECO:0000134
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of anthranilate
type: Reaction
reversible: true
kinetic law: MODEL1310110059#

metaR HAS1
is version of: http://identifiers.org/ec-code/2.4.1.212
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
reactant: MODEL1310110059#
name: hyaluronan synthase

metaR r0616
is: SBO:0000176
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
type: Reaction
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_cdb4a315_6a9d_465e_be93_44dd6d653f22
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: O75251
boundary condition: true
initial amount: NaN
constant: false
name: NDUFS7
is encoded by: hsa:374291

http://identifiers.org/biomodels.db/MODEL1310110059#_cdb2422a_1530_4dc9_a938_ff365d8de2e5
name: AFMID
is: SBO:0000252
type: Species
initial amount: NaN
is: Q63HM1
has only substance units: false
is encoded by: hsa:125061
constant: false
initial concentration: NaN
boundary condition: true

metaR XOL7AH2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110059#
name: lipid, flip-flop intracellular transport
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_2e072df9_3f5e_4e6b_bf17_77f8f7f36c5f
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2687
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GGT5
is: P36269

metaM akg m
constant: false
is: SBO:0000247
is: HMDB00208
has only substance units: false
name: 2-Oxoglutarate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: C00026
type: Species
is: CHEBI:16810

metaM q10h2 m
type: Species
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Ubiquinol-10
constant: false

metaM core4 g
type: Species
is: SBO:0000247
name: Core 4
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C24H40N3O15X CHARGE: 0
initial concentration: 1.0
is: CHEBI:16478
has only substance units: false

metaR GDPFUCtg
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
product: MODEL1310110059#
modifier: MODEL1310110059#
name: GDPFuc Golgi transport via CMP antiport
type: Reaction
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_561106ab_3387_41e8_9bc2_cdbae55b4212
is: SBO:0000252
is: Q9UG56
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:23761
name: PISD
initial amount: NaN
type: Species

metaR ACOAD1fm
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
type: Reaction
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reversible: false
modifier: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_c21bd281_8ff4_4789_9500_c91f27736ff4
name: SLC6A14
initial amount: NaN
is encoded by: hsa:11254
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: Q9UN76
boundary condition: true
is: SBO:0000252

metaR S6TASE9ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110059#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
product: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaM hs deg3 l
is: CHEBI:16126
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: heparan sulfate, degradation product 3
type: Species
has only substance units: false

metaM subeac x
has only substance units: false
initial amount: NaN
is: HMDB00893
name: suberic acid
type: Species
boundary condition: false
notes: FORMULA: C8H12O4 CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR LEUKTRF4t
fast: false
kinetic law: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
name: leukotriene F4 transport
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185

metaR PRASCS
modifier: MODEL1310110059#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.6
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
is: SBO:0000176
reversible: true
reactant: MODEL1310110059#

metaR r0617
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
type: Reaction
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#

metaR FAOXC226C225x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaR FAOXC101C102m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaM ppi c
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00250
initial concentration: 1.0
is: C00013
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3
has only substance units: false
boundary condition: false
is: CHEBI:0
constant: false

metaR r0722
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: true
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/4.2.3.12
reactant: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_513143db_a12e_454f_981a_bc85cc4523a6
boundary condition: true
constant: false
is: B3KQV3
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PIP4K2C
is encoded by: hsa:79837

metaR C181OHc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR AG13T18g
kinetic law: MODEL1310110059#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_d77cd7e7_02d2_4d31_900f_e091cf88ff31
is: SBO:0000252
has only substance units: false
constant: false
is: Q9NPH0
is encoded by: hsa:51205
type: Species
initial amount: NaN
initial concentration: NaN
name: ACP6
boundary condition: true

metaM c8crn c
name: octanoyl carnitine
boundary condition: false
constant: false
is: HMDB00791
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H29NO4 CHARGE: 0
type: Species
is: C02838
initial concentration: 1.0

metaR CYTK4n
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110059#
name: cytidylate kinase (dCMP,GTP),nuclear
is: SBO:0000176
fast: false

metaR LNLCCPT1
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110059#
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000269

metaM dhap c
is: http://identifiers.org/pubchem.compound/3411
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01473
is: CHEBI:57642
is: C00111
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Dihydroxyacetone phosphate

metaR APOCF
reactant: MODEL1310110059#
type: Reaction
reversible: false
is: SBO:0000176
name: Apocarboxylase formation
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
product: MODEL1310110059#

metaR RE3074X
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: true
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
type: Reaction
fast: false
name: RE3074
is: SBO:0000176
kinetic law: MODEL1310110059#

metaR TMDPK
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.6.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_7fd8a527_1d00_4c7f_9474_389ef88f3d3f
initial concentration: NaN
name: PDE9A
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252

metaR CYTD
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
product: MODEL1310110059#
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.5
name: cytidine deaminase
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000254

metaR DCMPDA
fast: false
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000254
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
name: dCMP deaminase
is version of: http://identifiers.org/ec-code/3.5.4.12
modifier: MODEL1310110059#
is: SBO:0000176

metaR r0723
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110059#
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110059#_b2f8e547_cc7d_4260_8046_7572ab2b7049
name: COX5B
initial amount: NaN
is: Q53YB7
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:1329
initial concentration: NaN
has only substance units: false

metaR FAOXC184C164m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaM 2octpencoa m
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
name: 2,6,9,12,15-octadecapentenoylcoa
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_7fba8d30_3a5e_439d_9ca3_54bb20336fe7
name: SLC27A2
boundary condition: true
type: Species
is: O14975
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11001
has only substance units: false
is: SBO:0000252
constant: false

metaR ADK1m
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase, mitochondrial
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
fast: false
reversible: true
type: Reaction
product: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_626405bb_ba64_4409_92d1_21d0a000079a
boundary condition: true
has only substance units: false
name: EHHADH
constant: false
initial concentration: NaN
is encoded by: hsa:1962
type: Species
is: SBO:0000252
is: Q9NY65
initial amount: NaN

metaR LNLCCPT2
reactant: MODEL1310110059#
product: MODEL1310110059#
name: carnitine transferase
fast: false
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_6d641dfa_f974_4290_849b_a3788c985e9f
has only substance units: false
is: SBO:0000252
type: Species
is: B4DKS0
boundary condition: true
constant: false
name: SLC16A1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6566

metaR r0724
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
fast: false
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000

metaM o2 x
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C00007
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
has only substance units: false
name: O2
type: Species
constant: false
is: CHEBI:15379

http://identifiers.org/biomodels.db/MODEL1310110059#_ebcd3b5b_977e_4def_8a89_276df607e581
has only substance units: false
is encoded by: hsa:517
initial concentration: NaN
constant: false
is: SBO:0000297
type: Species
has part: Q06055
boundary condition: true
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2

http://identifiers.org/biomodels.db/MODEL1310110059#_162df250_2151_4edb_978d_c5b6eb7362ea
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1120
is: Q9Y259
boundary condition: true
name: CHKB
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_854319c0_0a3f_4464_b8c3_f94ed78288d6
constant: false
name: CDIPT
is: SBO:0000252
is: A8K3L7
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:10423

metaM ala D e
has only substance units: false
is: SBO:0000247
is: HMDB01310
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
boundary condition: false
name: D-alanine
constant: false
is: CHEBI:15570
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_efeabc2a_ea87_44ca_a20c_0297948abb95
boundary condition: true
name: GMPR2
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:51292
has only substance units: false
is: SBO:0000252
constant: false

metaM dhap e
initial concentration: 1.0
initial amount: NaN
type: Species
name: glycerone phosphate(2-)
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
constant: false
is: CHEBI:57642
has only substance units: false
boundary condition: false
is: HMDB01473
is: SBO:0000247

metaM xylu D c
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
type: Species
is: HMDB01644
constant: false
has only substance units: false
initial amount: NaN
name: D-xylulose
is: CHEBI:17140
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_0345492d_18f1_46d9_87ae_606448e4c19c
initial amount: NaN
name: ATP5C1
is: P36542
initial concentration: NaN
is encoded by: hsa:509
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

metaR HDD2COAtx
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
reversible: true
name: hdd2coa intracellular transport
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR r0002
reactant: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
fast: false
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
name: Active transport

metaR r1540
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
modifier: MODEL1310110059#
product: MODEL1310110059#
reversible: false
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_3663a399_7a72_481b_a10b_56e46d3ef167
has part: D6RDW3
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: GUCY1B2:GUCY1A3
has only substance units: false
is: SBO:0000297
is encoded by: hsa:2982
is encoded by: hsa:2974

http://identifiers.org/biomodels.db/MODEL1310110059#_cd2a4c87_1be9_4edf_8e9d_abbb9df80b32
has only substance units: false
name: ETFA
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2108
initial amount: NaN
is: SBO:0000252
is: P13804
type: Species

metaM ocdececrn m
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
constant: false
initial amount: NaN
initial concentration: 1.0
name: 11-octadecenoyl carnitine

metaR ARACHDt2
is: SBO:0000185
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110059#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaR S23T4g
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
kinetic law: MODEL1310110059#
is: SBO:0000176
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase
is described by: ECO:0000000
product: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.99.4
reversible: false
fast: false
modifier: MODEL1310110059#

metaR NAGLCAly
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
reversible: false
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: N-acetylglucosaminidase, lysosomal
type: Reaction
is: SBO:0000176
product: MODEL1310110059#

metaR ACt2r
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
name: acetate reversible transport via proton symport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110059#
type: Reaction

metaM xu1p D c
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: D-Xylulose 1-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
constant: false
type: Species
initial concentration: 1.0
is: HMDB06534
has only substance units: false

metaR EX adp
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM oxa c
is: CHEBI:30623
constant: false
is: SBO:0000247
is: HMDB02329
name: oxalate(2-)
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR G14Tg
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
reversible: false
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
reactant: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false

metaM o2 r
has only substance units: false
is: CHEBI:15379
type: Species
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
constant: false
is: HMDB01377
initial concentration: 1.0
is: C00007
initial amount: NaN
is: SBO:0000247

metaM c4dc x
is: SBO:0000247
constant: false
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H18NO6 CHARGE: -1
has only substance units: false
name: succinyl carnitine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: C02862

metaR NACHEX13ly
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false

metaR RE3243R
reversible: true
type: Reaction
modifier: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: RE3243
is: SBO:0000176
fast: false
product: MODEL1310110059#

metaR SERGLNNaEx
reactant: MODEL1310110059#
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM c6crn x
notes: FORMULA: C13H25NO4 CHARGE: 0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: hexanoyl carnitine
is: HMDB00705

metaR MM8Ber
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
reversible: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
fast: false
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_7bd84665_ef7c_4f05_83fa_56cb926f74f9
is encoded by: hsa:51557
type: Species
initial concentration: NaN
name: LGSN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q5TDP6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_b23b7e29_1c46_4560_b7df_15dac621bb0c
has only substance units: false
is encoded by: hsa:9377
type: Species
is: SBO:0000252
initial amount: NaN
name: COX5A
boundary condition: true
is: P20674
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_fde4f773_19d4_4c1a_bdb1_eee5e77d6bc4
type: Species
is: P05062
constant: false
is encoded by: hsa:229
has only substance units: false
name: ALDOB
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_fae711d1_29b4_41a9_aad6_bcf10c52a0ac
boundary condition: true
name: SLCO1A2
is: P46721
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6579
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM hs deg20 l
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
constant: false
is: CHEBI:16126
is: SBO:0000247
name: heparan sulfate, degradation product 20
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM 6hoxmelatn c
is: HMDB04081
is: http://identifiers.org/pubchem.compound/7954
type: Species
name: 6-Hydroxymelatonin
boundary condition: false
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
has only substance units: false
initial amount: NaN
is: C05643
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR GLUt2m
is: SBO:0000185
type: Reaction
fast: false
name: L-glutamate reversible transport via proton symport, mitochondrial
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110059#
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reversible: true

metaM hco3 c
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00595
is: SBO:0000247
is: CHEBI:17544
name: Bicarbonate
initial amount: NaN
is: C00288
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ef6ac616_dabd_4f75_9d68_a65e296ba89b
is encoded by: hsa:10327
boundary condition: true
is: P14550
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: AKR1A1
type: Species
is: SBO:0000252

metaR COQ3m
is version of: http://identifiers.org/ec-code/2.1.1.114
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
name: methyltransferase COQ3
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
type: Reaction
kinetic law: MODEL1310110059#

metaM arachd l
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
type: Species
is: HMDB01043
has only substance units: false
name: arachidonate
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:32395
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_a0c3698d_b772_46c9_baee_481c5e4f0c0c
is: P22413
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5167
initial amount: NaN
name: ENPP1
boundary condition: true
is: SBO:0000252

metaM g3p c
initial amount: NaN
constant: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: C00661
initial concentration: 1.0
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3930
is: CHEBI:58027
name: Glyceraldehyde 3-phosphate
is: HMDB01112
boundary condition: false
is: SBO:0000247

metaM lnlccrn m
name: Linoleyl carnitine
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB06469
type: Species
has only substance units: false
boundary condition: false

metaM xol7ah c
boundary condition: false
is: SBO:0000247
is: HMDB06892
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:2290
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
initial concentration: 1.0
name: 7alpha-hydroxy-5beta-cholestan-3-one

metaR CYTDtm
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110059#
name: cytidine facilated transport in mitochondria
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110059#

metaR ACACt2m
fast: false
kinetic law: MODEL1310110059#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
name: Acetoacetate mitochondrial transport via H+ symport
type: Reaction
modifier: MODEL1310110059#

metaR GLYBt4 2 r
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Betaine transport (sodium symport) (2:1)
reversible: true

metaR S2TASE3ly
type: Reaction
name: iduronate-2-sulfatase, lysosomal
reactant: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110059#
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110059#_b413500c_7a1c_4145_972e_178245b51fac
initial concentration: NaN
is encoded by: hsa:2235
name: FECH
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: P22830

metaR RE1903R
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
name: RE1903
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ad8ac1cf_4330_4e69_9b5a_e20375b8f12b
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:515
is: SBO:0000252
constant: false
is: P24539
name: ATP5F1
type: Species

metaR HAS2
reactant: MODEL1310110059#
fast: false
is: SBO:0000185
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.212
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110059#
name: hyaluronan synthase

metaR NMNtn
is: SBO:0000185
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
name: NMN transport, nuclear trhough pore
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_e2ecc221_e4b9_4d22_b023_a77adb79e2a3
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:6916
name: TBXAS1
is: Q53F23
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_94ba41ed_3614_4a26_b04f_2be5532d32cd
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: PLCG1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5335
boundary condition: true
is: P19174

metaR r1544
kinetic law: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_42379876_8b2e_4419_85ea_ce9d3db1862f
name: _AA278423_1_c
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:AA278423

metaR CMPSASn
kinetic law: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.43
is: SBO:0000176
product: MODEL1310110059#
name: CMP sialic acid synthase, nuclear
is described by: ECO:0000304
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
type: Reaction
reactant: MODEL1310110059#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_457630bc_e712_4bb5_bf82_1cbe8085d0af
is: SBO:0000252
boundary condition: true
name: B3GNT8
type: Species
has only substance units: false
is encoded by: hsa:374907
constant: false
initial concentration: NaN
initial amount: NaN

metaR r2353
kinetic law: MODEL1310110059#
type: Reaction
fast: false
reactant: MODEL1310110059#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110059#

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaM xol7a r
name: 20-hydroxycholesterol
type: Species
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: HMDB01496
is: SBO:0000247
is: CHEBI:1296
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaM o2 n
name: dioxygen
type: Species
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:15379

http://identifiers.org/biomodels.db/MODEL1310110059#_b79ade6f_c702_4aa1_934f_87b0ce7aa933
is encoded by: hsa:1892
initial concentration: NaN
has only substance units: false
is: P30084
type: Species
name: ECHS1
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_e8be721c_394b_4c72_9e96_4aaf800c1668
constant: false
is encoded by: hsa:2805
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P17174
name: GOT1

metaM adp c
boundary condition: false
initial amount: NaN
name: ADP
constant: false
is: SBO:0000247
is: CHEBI:16761
initial concentration: 1.0
is: HMDB01341
has only substance units: false
is: http://identifiers.org/pubchem.compound/3310
is: C00008
type: Species

metaM ppi m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
is: SBO:0000247
is: HMDB00250
constant: false
has only substance units: false
is: CHEBI:33019
boundary condition: false
type: Species
is: C00013

metaM hco3 e
is: CHEBI:17544
boundary condition: false
is: HMDB00595
initial amount: NaN
is: C00288
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: Bicarbonate
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaR FAS80COA L
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
product: MODEL1310110059#
reactant: MODEL1310110059#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#

metaR ACt2m
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110059#
name: acetate mitochondrial transport via proton symport
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD

metaR NRVNCCOAtx
reversible: true
kinetic law: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
name: fatty acid intracellular transport

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaM dhea c
type: Species
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
boundary condition: false
name: 3beta-hydroxyandrost-5-en-17-one
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:28689
is: HMDB00077
initial concentration: 1.0

metaR r2354
is: SBO:0000185
product: MODEL1310110059#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110059#
name: Organic anion transporter 5 Utilized transport
type: Reaction

metaR DHPR2
reversible: false
is described by: ECO:0000304
name: 6,7-dihydropteridine reduction
fast: false
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
is: SBO:0000176

metaM hs deg19 l
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06210
initial concentration: 1.0
name: heparan sulfate, degradation product 19
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
type: Species
boundary condition: false
has only substance units: false

metaM chlstol r
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: CHEBI:16290
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: HMDB06842

metaR CYTK14n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110059#
name: cytidylate kinase (dCMP,CTP),nuclear
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
reversible: true

metaM bilglcur r
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species
boundary condition: false
has only substance units: false

metaR GULNter
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110059#
type: Reaction
name: L-gulonate endoplasmic reticular export
is described by: ECO:0000000
product: MODEL1310110059#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_0d978443_2325_40c8_acb1_719a95efe2a0
initial concentration: NaN
is: P30613
is encoded by: hsa:5313
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: PKLR
is: SBO:0000252

metaM tag hs e
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: triglyceride
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false
constant: false
is: CHEBI:17855

metaM o2 m
type: Species
is: C00007
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
name: O2
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01377
initial concentration: 1.0

metaR ADKd
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
modifier: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
name: adenylate kinase (d form)

metaR CHSTEROLt3
product: MODEL1310110059#
is: SBO:0000185
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: cholesterol intracellular transport
reversible: true

metaR CDS
fast: false
modifier: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.41
type: Reaction
product: MODEL1310110059#
name: phosphatidate cytidylyltransferase
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false

metaR C14STRr
name: C-14 sterol reductase
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70
reactant: MODEL1310110059#
is described by: ECO:0000134
product: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_54d69dfb_f39a_4df9_b491_3bedea1206e5
name: NME2
is encoded by: hsa:4831
has only substance units: false
is: P22392
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM arachd r
initial concentration: 1.0
has only substance units: false
is: CHEBI:32395
boundary condition: false
type: Species
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
is: SBO:0000247
initial amount: NaN
constant: false

metaM pi e
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00973
initial amount: NaN
boundary condition: false
is: CHEBI:43474
is: C00009
constant: false
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaM ksi pre31 g
has only substance units: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: CHEBI:58053
is: HMDB00175
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00130
initial amount: NaN
type: Species
name: keratan sulfate I biosynthesis, precursor 31

metaM dcholcoa c
is: SBO:0000247
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
name: chenodeoxycholoyl coenzyme a
boundary condition: false
type: Species
is: CHEBI:28701
is: HMDB06292
initial concentration: 1.0
initial amount: NaN

metaR r1546
type: Reaction
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#

metaR SPRMS
product: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD
name: spermine synthase
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
reversible: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.5.1.22
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110059#_6511b158_7a39_4d1c_be5d_a50ed33225ee
initial amount: NaN
boundary condition: true
is encoded by: hsa:5286
initial concentration: NaN
type: Species
has only substance units: false
name: PIK3C2A
constant: false
is: O00443
is: SBO:0000252

metaR FAOXC205C185m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaR FAOXC15ATPx
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaR SPH1Pte
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
name: sph1p transport

metaR r2355
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
product: MODEL1310110059#

metaR r1843
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110059#
is: SBO:0000185
type: Reaction

metaR G5SADs
type: Reaction
reversible: false
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:Needed in L-proline biosynthesis
name: L-glutamate 5-semialdehyde dehydratase (spontaneous)
is: SBO:0000176

metaR CHSTEROLt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: cholesterol intracellular transport
is described by: ECO:0000000
product: MODEL1310110059#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaR GUMGCHLe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR r0610
is: SBO:0000176
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
kinetic law: MODEL1310110059#
reversible: true
type: Reaction

metaM leuleu c
notes: FORMULA: C12H24N2O3 CHARGE: 0
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/94244
name: Leucylleucine
constant: false
is: SBO:0000247
type: Species

metaR ASNGLNNaEx
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_9574205e_08cf_4f01_b4bd_bbb7182cbf05
is encoded by: hsa:1798
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: DPAGT1
initial concentration: NaN
is: Q9H3H5
type: Species

metaR EX pectindchac LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-deoxycholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_22790b9f_8444_4152_a14d_e974dcf2b805
is encoded by: hsa:954
has only substance units: false
name: ENTPD2
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q5SPY7

http://identifiers.org/biomodels.db/MODEL1310110059#_2e092831_0e26_4172_a3a7_a2da8425e43a
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:7001
type: Species
has only substance units: false
name: PRDX2
is: SBO:0000252
initial amount: NaN

metaR r2356
is described by: ECO:0000000
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
fast: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_905ebbc9_ce8a_48ca_b6cb_6274a1300cb6
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:7378
is: Q16831
name: UPP1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_35d1d705_7386_43c2_a2e0_945999fabcc5
boundary condition: true
is encoded by: hsa:AI090874
type: Species
is: SBO:0000252
initial amount: NaN
name: _AI090874_1_c
has only substance units: false
constant: false
initial concentration: NaN

metaM ksi pre11 g
has only substance units: false
is: CHEBI:28067
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
constant: false
name: keratan sulfate I biosynthesis, precursor 11
initial amount: NaN

metaR SERALANaEx
is described by: ECO:0000269
kinetic law: MODEL1310110059#
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
reversible: false
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
fast: false

metaR CHSTEROLt1
product: MODEL1310110059#
fast: false
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
type: Reaction
name: cholesterol intracellular transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_5a4be222_274b_4d89_bcf9_874df801f0af
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:8875
constant: false
has part: O95497
is encoded by: hsa:8876
is encoded by: hsa:55350
has part: A8K7W0
type: Species
boundary condition: true
name: VNN3:VNN2:VNN1
initial amount: NaN
has only substance units: false

metaR FAOXC226C225m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR PRGNLONESULT
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.2
is version of: http://identifiers.org/ec-code/2.8.2.14
fast: false
name: steroid sulfotransferase
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ

metaM pi c
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00973
initial amount: NaN
name: hydrogenphosphate
is: CHEBI:43474
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2
is: C00009
constant: false

metaM itacon m
initial amount: NaN
has only substance units: false
is: HMDB02092
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
boundary condition: false
is: CHEBI:17240
constant: false
name: itaconate(2-)
type: Species
initial concentration: 1.0

metaR r0009
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
fast: false

metaR r0611
modifier: MODEL1310110059#
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
type: Reaction
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
is version of: http://identifiers.org/ec-code/1.2.3.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
kinetic law: MODEL1310110059#
is described by: ECO:0000000

metaM ksii core4 pre7 g
type: Species
name: keratan sulfate II biosynthesis, precursor 7
constant: false
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00175
has only substance units: false
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110059#_1108860b_bd9c_4332_b1cd_b944d5da0e7d
constant: false
is: SBO:0000252
initial amount: NaN
name: SLCO3A1
is encoded by: hsa:28232
initial concentration: NaN
is: Q9UIG8
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_69fcaf8d_be25_40cb_9c5b_fb9faf34c62f
type: Species
name: SLC14A2
initial concentration: NaN
boundary condition: true
is: Q15849
is: SBO:0000252
is encoded by: hsa:8170
constant: false
has only substance units: false
initial amount: NaN

metaM k e
is: C00238
has only substance units: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
constant: false
is: CHEBI:29103
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: potassium
is: HMDB00586

http://identifiers.org/biomodels.db/MODEL1310110059#_527729a1_68cd_4a4d_beb3_dc144342712b
is encoded by: hsa:2746
is: E9KL48
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: GLUD1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_485a14e5_cb98_46be_af81_f6d59e418475
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9415
constant: false
has only substance units: false
type: Species
boundary condition: true
is: O95864
name: FADS2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_9006c8ce_220b_4027_a56c_3e80be1ffc26
has part: O15270
has only substance units: false
initial amount: NaN
type: Species
has part: O15269
is encoded by: hsa:9517
name: SPTLC1:SPTLC2
is: SBO:0000297
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10558
constant: false

metaR r1548
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110059#
is: SBO:0000185

metaM m4mpdol L r
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_e5f2bcb8_527c_48b2_9b7d_ec23a5276b85
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:53630
name: BCMO1
constant: false
type: Species
is: Q9HAY6
is: SBO:0000252
initial amount: NaN

metaM dhap m
boundary condition: false
is: SBO:0000247
is: HMDB01473
constant: false
has only substance units: false
name: Dihydroxyacetone phosphate
is: http://identifiers.org/pubchem.compound/3411
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00111

http://identifiers.org/biomodels.db/MODEL1310110059#_4edf199f_41cb_41c0_90d2_73e670cd6d0a
boundary condition: true
constant: false
is: O95497
name: VNN1
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:8876
is: SBO:0000252
initial concentration: NaN

metaM ala D c
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
is: SBO:0000247
constant: false
is: CHEBI:15570
initial amount: NaN
is: HMDB01310
boundary condition: false
name: D-alanine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_f1233bb6_1117_4607_8856_bc801d660f73
has only substance units: false
type: Species
is encoded by: hsa:79053
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: ALG8
boundary condition: true

metaR CO2t
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: CO2 transporter via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD

http://identifiers.org/biomodels.db/MODEL1310110059#_1def1523_d982_47be_893e_7be64e244f59
name: NDUFA5
is: Q16718
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4698

metaR C5DCe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM acgal c
has only substance units: false
is: CHEBI:28037
is: HMDB00212
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
name: N-acetyl-D-galactosamine
is: SBO:0000247

metaR r0726
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR r0156
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
modifier: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000176
reversible: false
fast: false

metaR PRISTtx
fast: false
name: prist peroxisomal transport
type: Reaction
product: MODEL1310110059#
is: SBO:0000185
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
is described by: ECO:0000000
reversible: true

metaR RE1836X
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.176
name: RE1836
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
is: SBO:0000176
fast: false

metaR r1547
reactant: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110059#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR BAMPPALDOX
is described by: ECO:0000212
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
type: Reaction
fast: false
product: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB

metaM hista c
is: CHEBI:58432
type: Species
constant: false
boundary condition: false
is: HMDB00870
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: histamium
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0

metaR C160CPT1
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
reactant: MODEL1310110059#
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
name: production of Palmitoylcarnitine
product: MODEL1310110059#

metaR UREAt
fast: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
kinetic law: MODEL1310110059#
name: Urea transport via facilitate diffusion

http://identifiers.org/biomodels.db/MODEL1310110059#_338839b5_cdf3_4349_977b_d2a879ee2ba5
initial amount: NaN
is encoded by: hsa:2739
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: GLO1
initial concentration: NaN
is: Q04760

metaM k c
is: HMDB00586
has only substance units: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
type: Species
is: CHEBI:29103
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: potassium

http://identifiers.org/biomodels.db/MODEL1310110059#_a4a589a9_321c_4f1c_855a_f567cbd6140f
is encoded by: hsa:8875
initial concentration: NaN
name: VNN2
constant: false
is: A8K7W0
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r0614
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is described by: ECO:0000000
reversible: true
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
fast: false
is: SBO:0000176

metaR r0157
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.2
type: Reaction
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110059#

metaM lnlccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB06469
initial amount: NaN
initial concentration: 1.0

metaM tetdece1crn e
type: Species
boundary condition: false
has only substance units: false
name: tetradecenoyl carnitine
notes: FORMULA: C21H39NO4 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB02014
constant: false

metaR C160CPT2
modifier: MODEL1310110059#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000269
product: MODEL1310110059#
type: Reaction
name: C160 transport into the mitochondria
fast: false

metaM tetpent3coa c
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
constant: false
initial amount: NaN
is: C16167
initial concentration: 1.0
type: Species
name: tetracosapentaenoyl coenzyme A, n-3
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_50ccb436_efa2_495d_89a5_afb527fb6d5b
constant: false
is encoded by: hsa:6483
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q16842
type: Species
name: ST3GAL2

metaM akg x
initial concentration: 1.0
type: Species
is: HMDB00208
initial amount: NaN
name: 2-oxoglutarate(2-)
boundary condition: false
is: CHEBI:16810
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
constant: false

metaM tag hs c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17855
type: Species
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
has only substance units: false
name: triglyceride
constant: false
boundary condition: false

metaM orot5p c
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57538
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
initial amount: NaN
has only substance units: false
is: HMDB00218
name: Orotidine 5'-phosphate
is: C01103

metaR BDHm
fast: false
kinetic law: MODEL1310110059#
type: Reaction
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.30
product: MODEL1310110059#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
modifier: MODEL1310110059#

metaM CE5121 m
name: trans-3-decenoyl-CoA
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:57449

metaR r2352
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r0615
type: Reaction
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is version of: http://identifiers.org/ec-code/2.3.1.168
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
reversible: true

metaR r0728
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
fast: false
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true

metaM HC01406 m
name: 3-Oxooctanoyl-CoA
is: SBO:0000247
constant: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
type: Species
initial amount: NaN
is: CHEBI:28264
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM CE5125 x
is: SBO:0000247
type: Species
is: CHEBI:15748
initial amount: NaN
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
has only substance units: false
is: HMDB00127
name: (2S)-pristanoyl-CoA
initial concentration: 1.0
boundary condition: false

metaR FAOXC183C163Gm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM hista e
initial concentration: 1.0
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
constant: false
is: HMDB00870
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: histamium
is: CHEBI:58432

metaR FAOXC184C164x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaR r1549
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110059#
is described by: ECO:0000000
type: Reaction

metaM pi g
is: HMDB00973
constant: false
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
initial amount: NaN
is: CHEBI:43474
boundary condition: false
name: hydrogenphosphate
is: SBO:0000247
has only substance units: false

metaR C161CPT12
is: SBO:0000176
name: carnitine O-palmitoyltransferase
fast: false
is described by: ECO:0000269
modifier: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110059#

metaR FAOXC12DCTc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaM amp r
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: C00020
constant: false
initial concentration: 1.0
is: CHEBI:456215
name: AMP
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00045
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_d63069a5_c167_4318_b857_a5c9bf9179a3
boundary condition: true
initial amount: NaN
is encoded by: hsa:341947
name: COX8C
is: Q7Z4L0
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_58fbd762_951b_4abd_983c_acdb5ea45c46
initial amount: NaN
boundary condition: true
is: Q9UBX3
has only substance units: false
name: SLC25A10
constant: false
initial concentration: NaN
is encoded by: hsa:1468
type: Species
is: SBO:0000252

metaM ocdcea r
is: SBO:0000247
initial amount: NaN
is: C00712
is: HMDB00207
is: CHEBI:0
type: Species
constant: false
boundary condition: false
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_57b86b10_fcbe_4a80_992b_42788cf4ac6c
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: _728637_1_c
is encoded by: hsa:728637
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM ha deg1 l
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C22H33N2O16 CHARGE: -1
type: Species
initial concentration: 1.0
name: hyaluronan degradation product 1
boundary condition: false
is: CHEBI:16336

metaM arachdcoa x
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
is: SBO:0000247
type: Species
constant: false
name: arachidonoyl-CoA(4-)
boundary condition: false
is: HMDB06523
initial amount: NaN

metaR FAOXC102C81x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a659f8f2_b21b_4aa1_9429_233215c6df1f
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P14060
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: HSD3B1
is encoded by: hsa:3283

metaM hmgcoa m
is: HMDB01375
boundary condition: false
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:15467
initial concentration: 1.0
has only substance units: false

metaM c16dc e
name: Hexadecanedioic acid mono-L-carnitine ester
boundary condition: false
constant: false
is: HMDB00712
notes: FORMULA: C23H42NO6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaR r0178
fast: false
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.5.1.21
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110059#
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_081b0381_5a3e_40cf_9cf1_1ec4fb2f1b8c
boundary condition: true
has only substance units: false
is encoded by: hsa:3141
is: P50747
initial amount: NaN
name: HLCS
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM xol7ah3 c
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: HMDB12455
is: CHEBI:28540
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,26-triol

metaR FAOXC123x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaM h2o2 x
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Hydrogen peroxide
is: CHEBI:16240
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB03125

metaR r0472
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110059#

metaM glcur e
type: Species
is: HMDB00127
initial amount: NaN
constant: false
name: D-glucuronate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false

metaR SFCYSc
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:non-enzymatic reaction. Sulfocysteine is excreted in the urine.One proton added for elemental balancing.
is: SBO:0000176
product: MODEL1310110059#
fast: false
is described by: ECO:0000134
name: Formation of sulfocysteine
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
reversible: true

metaM CE5161 r
constant: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
is: CHEBI:57923
is: SBO:0000247
type: Species
initial amount: NaN

metaR SIAT4Bg
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
reactant: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
kinetic law: MODEL1310110059#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_41e1bf1a_07f7_49f2_b53d_8ab7f522f94e
is encoded by: hsa:124935
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q8N370
constant: false
has only substance units: false
name: SLC43A2
type: Species

metaR r2338
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is described by: ECO:0000000
reactant: MODEL1310110059#

metaR CHATn
is: SBO:0000176
reactant: MODEL1310110059#
is described by: ECO:0000269
fast: false
reversible: true
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.6
type: Reaction
kinetic law: MODEL1310110059#
name: Choline O-acetyltransferase

http://identifiers.org/biomodels.db/MODEL1310110059#_616ee3d2_5eed_44cd_a15f_1fc2ba0e9a65
name: LEFTY1
initial concentration: NaN
is: O75610
constant: false
is encoded by: hsa:10637
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaM ksi deg41 l
has only substance units: false
is: HMDB00143
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 41
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:12936
notes: FORMULA: C34H58N2O26 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110059#_1d803db7_18de_4847_8eae_972da32f99f5
name: GLA
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q53Y83
is encoded by: hsa:2717

metaR FERO
is described by: ECO:0000134
product: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
reversible: false
name: ferroxidase
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_dbcde136_1291_4e9a_bfa9_fffdbac62a2b
is encoded by: hsa:8659
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: ALDH4A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_8cca8504_2cda_4485_ab70_ec3c1a150de1
is: SBO:0000252
constant: false
is: P11310
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ACADM
has only substance units: false
is encoded by: hsa:34
type: Species

metaR TREHe
reversible: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: alpha,alpha-trehalase
fast: false
reactant: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
is version of: http://identifiers.org/ec-code/3.2.1.28

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR PSt3
product: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000185
name: phosphatidylserine transport
reversible: true

metaR 10FTHFtm
is: SBO:0000185
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_65c89c01_5e8a_4200_9a0c_8b7d7e3f24c4
initial concentration: NaN
constant: false
name: PFKFB1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5207
type: Species
is: P16118
initial amount: NaN
has only substance units: false

metaM estrones e
constant: false
has only substance units: false
is: CHEBI:60050
is: HMDB01425
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
type: Species
initial concentration: 1.0
name: estrone 3-sulfate(1-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_17799b07_9771_45df_bcb5_8525da725d53
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:57030
name: SLC17A7
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9P2U7

metaM HC02204 e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27624
constant: false
type: Species
boundary condition: false
name: prostaglandin-b1
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959

metaM aacoa c
name: Acetoacetyl-CoA
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: C00332
is: HMDB01484
has only substance units: false
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: CHEBI:57286

http://identifiers.org/biomodels.db/MODEL1310110059#_bacfc05c_bbf7_4b68_b591_a1613f519654
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:9583
initial amount: NaN
is: Q9Y227
has only substance units: false
name: ENTPD4

metaR EX tdcrn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_42e27fce_0cc4_4eea_af10_3b750470eafd
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: B4GALT2
boundary condition: true
constant: false
is encoded by: hsa:8704
initial concentration: NaN

metaM aps c
is: HMDB01003
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 5'-adenylyl sulfate(2-)
is: CHEBI:58243
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
has only substance units: false
boundary condition: false

metaM dhcholestanate c
is: CHEBI:16577
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
is: HMDB00359
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR PCRNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
product: MODEL1310110059#
type: Reaction
reversible: false
reactant: MODEL1310110059#
name: transport into the mitochondria from cytosol (carnitine)
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185

metaM prostgf2 c
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01139
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
name: prostaglandin F2alpha(1-)
constant: false
is: SBO:0000247
is: CHEBI:57404

http://identifiers.org/biomodels.db/MODEL1310110059#_82893593_1279_4085_8d66_56e2dbebc006
name: MCCC1:MCCC2
boundary condition: true
is: SBO:0000297
has part: Q9HCC0
is encoded by: hsa:64087
initial amount: NaN
constant: false
has part: Q96RQ3
is encoded by: hsa:56922
type: Species
initial concentration: NaN
has only substance units: false

metaM cs e deg1 l
type: Species
is: CHEBI:57737
initial amount: NaN
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
constant: false
is: SBO:0000247
is: HMDB00868

metaM 3hpcoa m
name: 3-hydroxypropanoyl-CoA(4-)
has only substance units: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: CHEBI:58528
is: SBO:0000247
is: HMDB06807
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaM HC02204 c
is: CHEBI:27624
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
type: Species
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-b1
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r1851
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FACOAL1822
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
modifier: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reversible: true
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
is: SBO:0000176

metaM strdnc e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: stearidonic acid C18:4, n-3
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205608
type: Species
constant: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
is: HMDB06547
is: SBO:0000247

metaM docohepcoa m
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
is: SBO:0000247
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
initial amount: NaN

metaM estrones c
constant: false
is: SBO:0000247
is: HMDB01425
initial concentration: 1.0
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
initial amount: NaN
is: CHEBI:60050
boundary condition: false
name: estrone 3-sulfate(1-)
type: Species
has only substance units: false

metaM cs b deg1 l
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00812
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
has only substance units: false
initial amount: NaN
is: CHEBI:16953
type: Species
initial concentration: 1.0

metaR PETOHMm hs
product: MODEL1310110059#
is: SBO:0000176
name: phosphatidylethanolamine N-methyltransferase
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
is described by: ECO:0000254

metaM gchola c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
constant: false
type: Species
is: HMDB00138
has only substance units: false
is: CHEBI:58235
name: glycocholate
boundary condition: false
is: SBO:0000247

metaR RE2660C
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
reversible: true
name: RE2660
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_74ba0e5c_8f06_4a68_b86f_1e2f74eaf8b6
is encoded by: hsa:2588
is encoded by: hsa:5476
has part: P34059
has part: P16278
has part: Q99519
boundary condition: true
has only substance units: false
is: SBO:0000297
initial amount: NaN
constant: false
is encoded by: hsa:4758
name: GALNS:GLB1:NEU1:CTSA
is encoded by: hsa:2720
initial concentration: NaN
has part: P10619
type: Species

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_5e267773_20f0_4578_8b8f_5547df8e65fb
boundary condition: true
constant: false
name: ACOX3
is: SBO:0000252
is encoded by: hsa:8310
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: O15254

metaM gullac r
constant: false
is: HMDB03466
initial amount: NaN
type: Species
name: L-gulono-1,4-lactone
has only substance units: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:17587

http://identifiers.org/biomodels.db/MODEL1310110059#_b97cdc47_e922_4516_a0e5_d178594b2727
initial amount: NaN
is encoded by: hsa:206
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: _206_1_c
has only substance units: false

metaR r2335
product: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR r0173
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.6.1.19
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#

metaR FACOAL1821
product: MODEL1310110059#
fast: false
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
is: SBO:0000176
name: fatty-acid--CoA ligase

metaR FAOXC204
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_471ca5dc_69e0_4217_bc09_3c17903cea9d
name: _AI373818_1_m
constant: false
is encoded by: hsa:AI373818
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR G14T19g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
kinetic law: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110059#

metaR r0475
reversible: true
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110059#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110059#_28120f9f_c09f_4c41_9432_9307fa1cb5e4
is encoded by: hsa:5296
type: Species
is: O00459
constant: false
initial concentration: NaN
has only substance units: false
name: PIK3R2
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_7a37e5e2_e805_44e5_b50a_ecbbd7cf9152
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:27306
is: O60760
type: Species
name: HPGDS
initial concentration: NaN

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_22dfbb2e_d278_49c5_8ae8_dec0529da7fc
is: SBO:0000252
is encoded by: hsa:37
is: P49748
name: ACADVL
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_03cc2554_6fff_439b_9442_c016853a11b7
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:2348
name: FOLR1

http://identifiers.org/biomodels.db/MODEL1310110059#_2f0f0355_82cd_44ec_b288_033e05fb63c9
type: Species
name: SLC17A1
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6568
has only substance units: false
constant: false
is: Q14916
initial concentration: NaN

metaR r2334
is described by: ECO:0000000
fast: false
product: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110059#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110059#
reversible: true
is: SBO:0000185

metaR 5HLTDL
is version of: http://identifiers.org/ec-code/4.1.1.28
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
product: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110059#

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR r0474
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaM strdnc c
name: stearidonic acid C18:4, n-3
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
type: Species
is: http://identifiers.org/pubchem.compound/47205608
is: C16300
constant: false
is: HMDB06547
boundary condition: false

metaR r0587
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is: SBO:0000176
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM stcoa c
name: Stearoyl-CoA (n-C18:0CoA)
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: CHEBI:57394
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01114
is: SBO:0000247
is: C00412

metaM gchola e
initial concentration: 1.0
constant: false
is: HMDB00138
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0
boundary condition: false
initial amount: NaN
name: glycocholate

http://identifiers.org/biomodels.db/MODEL1310110059#_e8108d87_960f_4f15_bfb6_0d51807b5c6f
name: PEMT
initial concentration: NaN
is encoded by: hsa:10400
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR S6T3g
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
kinetic law: MODEL1310110059#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
modifier: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.21
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_8e2d99ea_f49f_4c12_be1f_841deec4a0dd
has only substance units: false
constant: false
type: Species
name: DGKZ
is encoded by: hsa:8525
boundary condition: true
is: B7Z6M3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR FAOXC164C165m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaR S3TASE3ly
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
type: Reaction
is described by: ECO:0000000
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_fb3c130b_7d57_4b40_a8b2_b135374206b0
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:9551
name: ATP5J2
initial concentration: NaN
has only substance units: false
type: Species
is: Q6IBB3
boundary condition: true

metaR SFCYSe
name: Exit of sulfocysteine into extra-cellular space
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:sulfocysteine is exfreted in urine
is described by: ECO:0000134
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110059#
reversible: true

metaM glcur c
is: CHEBI:15748
is: HMDB00127
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

metaR r2333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000185
fast: false
product: MODEL1310110059#

metaM malthp e
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
name: maltoheptaose
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: C01936
initial concentration: 1.0

metaR r0170
is: SBO:0000176
fast: false
product: MODEL1310110059#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110059#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110059#

metaR r2497
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a52adf55_7013_4674_9d1f_44335490695a
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2643
boundary condition: true
is: SBO:0000252
name: GCH1
has only substance units: false
is: Q8IZH9
type: Species

metaR LALDO
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
fast: false
reversible: true
modifier: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_26b9902e_c03e_4262_b2f4_d26df20652ff
is encoded by: hsa:6389
is: SBO:0000252
is: P31040
initial concentration: NaN
type: Species
boundary condition: true
name: SDHA
has only substance units: false
initial amount: NaN
constant: false

metaR LYStm
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: Lysine mitochondrial transport via ornithine carrier
reversible: true
type: Reaction
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
reactant: MODEL1310110059#

metaM n2m2nm l
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C58H97N5O41 CHARGE: 0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:30825
initial concentration: 1.0
name: n2m2nmasn (w/o peptide linkage)
is: HMDB00573

metaM hexe3coa x
initial concentration: 1.0
is: HMDB06522
constant: false
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247
name: 3-hexenoylcoa
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_040ac9cf_250d_46ba_a09a_d1690ec6383a
is encoded by: hsa:5144
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: PDE4D
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q08499

metaR C121CPT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a832332e_11c0_41ae_9381_5fc8d47c7385
is: SBO:0000252
boundary condition: true
is: P00390
has only substance units: false
name: GSR
is encoded by: hsa:2936
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaM g3m8masn r
is: C05873
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C88H147N2O70X CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_c90f67b9_f18a_411a_bcfb_985e2cb49b8f
name: EHHADH
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1962
has only substance units: false
initial concentration: NaN
is: Q9NY65
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_5ef1e8aa_eee8_419d_98e6_1777534e51a5
is encoded by: hsa:6120
is: Q53TV9
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: RPE
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_cb7d182f_7eb1_4a6f_a03c_24d1671f0f67
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: NDUFA12
initial amount: NaN
is: SBO:0000252
is: F8VQS7
has only substance units: false
is encoded by: hsa:55967

metaR CRVNCtr
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
product: MODEL1310110059#
name: fatty acid transport via diffusion
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_030b7ad3_0b7e_4da8_b472_6130e4e4a2e1
constant: false
has only substance units: false
is: B4DYG5
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: PI4KA
is encoded by: hsa:5297
initial concentration: NaN

metaM prostgf2 e
constant: false
is: HMDB01139
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: prostaglandin F2alpha(1-)
has only substance units: false
is: CHEBI:57404
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_58ecb992_e5a6_4f44_a14e_bee380f29445
is encoded by: hsa:5279
initial amount: NaN
name: PIGC
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaM gam6p c
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01254
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: D-Glucosamine 6-phosphate
is: CHEBI:12962
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352

http://identifiers.org/biomodels.db/MODEL1310110059#_deb236cd_a898_4023_9777_43d363d6e9e7
initial concentration: NaN
name: NDUFS4
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: O43181
boundary condition: true
initial amount: NaN
is encoded by: hsa:4724

metaR r0584
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
is described by: ECO:0000000
product: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110059#

metaM dhcholestanate r
type: Species
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
is: HMDB00359
is: SBO:0000247

metaR FAOXC164C165x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaR GK1
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8
name: guanylate kinase (GMP:ATP)
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_f30be49f_27bd_4078_8aea_7caf499f207e
has only substance units: false
is: P30519
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3163
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: HMOX2

metaR L LACt4r
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
name: L-lactate reversible transport via sodium symport
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_25ad0413_dcd8_4a5d_9e90_48c2effbe526
name: INPP5E
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9NRR6
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56623

metaR SERASNNaEx
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_42b97e61_4613_48ce_9c85_a48da96cba93
initial concentration: NaN
is: P30084
initial amount: NaN
constant: false
type: Species
name: ECHS1
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:1892

metaR GALASE13ly
modifier: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reversible: false
type: Reaction
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM bilglcur c
constant: false
is: CHEBI:57767
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
initial amount: NaN
has only substance units: false

metaM c4dc c
initial amount: NaN
name: succinyl carnitine
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
has only substance units: false
is: C02862
type: Species
initial concentration: 1.0
constant: false
is: HMDB02013
boundary condition: false
notes: FORMULA: C11H18NO6 CHARGE: -1

metaR RE0512M
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE0512
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_9d5d6796_8a3c_40fc_a082_1ea00f9d892d
has only substance units: false
is: P08195
type: Species
name: SLC3A2
constant: false
is encoded by: hsa:6520
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_32fe901d_b0c5_4b32_a320_3ee788184e13
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O43280
is: SBO:0000252
type: Species
name: TREH
is encoded by: hsa:11181

metaR r0021
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_74c04eff_60c3_4ba9_b462_8b6b27ea6c13
constant: false
is: Q8N0X4
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: CLYBL
is encoded by: hsa:171425
has only substance units: false

metaM thr L c
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
name: L-threonine
constant: false
is: CHEBI:16857

http://identifiers.org/biomodels.db/MODEL1310110059#_e8270ddc_a9e4_4b64_a96b_a9434b298f60
has only substance units: false
name: INPP5J
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:27124
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: Q15735

http://identifiers.org/biomodels.db/MODEL1310110059#_3fc61cbe_65cb_425f_be36_0df3372e1dde
boundary condition: true
is encoded by: hsa:5151
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: PDE8A
initial concentration: NaN
is: O60658
initial amount: NaN

metaM leuktrB4 e
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
boundary condition: false
type: Species
is: HMDB01085
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
name: leukotriene B4(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_8db43d20_d173_43c8_aac3_3427e26ba18f
boundary condition: true
initial amount: NaN
is encoded by: hsa:6530
name: SLC6A2
has only substance units: false
constant: false
is: Q96KH8
is: SBO:0000252
type: Species
initial concentration: NaN

metaR PIPLCn
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
is: SBO:0000176
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
name: phosphatidylinositol phospholipase C, nucleus
product: MODEL1310110059#
fast: false

metaM stcoa m
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
type: Species
has only substance units: false
is: C00412
is: HMDB01114
is: SBO:0000247
is: CHEBI:57394
boundary condition: false
initial concentration: 1.0
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN
constant: false

metaR ATP1ter
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
type: Reaction
reactant: MODEL1310110059#
name: ADP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
reversible: true
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR ARGDCm
modifier: MODEL1310110059#
name: arginine decarboxylase (m)
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (113451.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.19 Confidence Level: 4 AUTHORS: PMID:14752610 NOTES:SAB m
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.19
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_6d671a94_7f5f_489d_82ed_b0da19fd015c
constant: false
initial concentration: NaN
is encoded by: hsa:4731
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: NDUFV3
initial amount: NaN

metaM taur c
has only substance units: false
is: HMDB00251
is: CHEBI:3544
initial concentration: 1.0
name: Taurine
initial amount: NaN
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
is: SBO:0000247
constant: false
is: C00245
boundary condition: false

metaR APAT2rm
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000212
product: MODEL1310110059#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110059#
type: Reaction

metaM m4mpdol L c
is: SBO:0000247
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
is: CHEBI:37633
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_6b9fdb33_fd1a_488a_b931_8abee33efca0
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: _H17063_1_c
is: SBO:0000252
is encoded by: hsa:H17063
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_4c3c3244_620f_4261_ac14_741bf3d60f4c
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110059#_bb50b646_4814_4775_89b7_66c30c6bc7d8
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _NOS2A_1_c
initial concentration: NaN
constant: false
is encoded by: hsa:NOS2A
type: Species

metaM cholcoaone x
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: HMDB06891
is: CHEBI:58507
initial amount: NaN
boundary condition: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467

metaM bilglcur e
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767

http://identifiers.org/biomodels.db/MODEL1310110059#_13804670_59fe_4606_922e_c9d759134ba0
boundary condition: true
has only substance units: false
is: Q9H2X9
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:57468
initial amount: NaN
name: SLC12A5

http://identifiers.org/biomodels.db/MODEL1310110059#_57545934_766e_4878_af85_94d575de4f2b
name: ACOT6
is encoded by: hsa:641372
boundary condition: true
is: SBO:0000252
is: Q3I5F7
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false

metaR FAOXC4C4DCc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a2cf52b9_4c58_45e2_a943_86931f277cb9
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: CDA
is: P32320
is encoded by: hsa:978
initial amount: NaN
boundary condition: true

metaM hmgcoa x
is: HMDB01375
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
name: Hydroxymethylglutaryl-CoA
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

http://identifiers.org/biomodels.db/MODEL1310110059#_b4d55927_c7c8_4ae2_bb2c_a077466f534e
boundary condition: true
constant: false
is encoded by: hsa:1375
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: CPT1B
type: Species
is: Q53FV7

metaR CTPS1
kinetic law: MODEL1310110059#
reversible: false
name: CTP synthase (NH3)
is: SBO:0000176
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/6.3.4.2
notes: GENE_ASSOCIATION: (1503.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false

metaR G14T7g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
modifier: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM leuktrB4 c
is: SBO:0000247
name: leukotriene B4(1-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
is: CHEBI:57461
initial amount: NaN
constant: false
type: Species
boundary condition: false

metaM c16dc c
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H42NO6 CHARGE: -1
initial concentration: 1.0
has only substance units: false
is: HMDB00712
type: Species
name: Hexadecanedioic acid mono-L-carnitine ester
constant: false

metaM dhcholestanate m
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16577
is: HMDB00359
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

metaR RE2660N
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is: SBO:0000176
reactant: MODEL1310110059#
name: RE2660
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_f26a48b9_1e28_48f1_89e9_b4d4bcfcbd00
constant: false
initial concentration: NaN
initial amount: NaN
name: DUT
is encoded by: hsa:1854
is: P33316
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR HSD17B42x
reversible: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
fast: false
name: hydroxysteroid (17-beta) dehydrogenase 4
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_69814fae_f210_4973_85bd_24dc678ac383
initial amount: NaN
name: AMPD3
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: B7Z763
is encoded by: hsa:272
constant: false
initial concentration: NaN

metaR r0580
is version of: http://identifiers.org/ec-code/1.3.99.7
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
product: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110059#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
reversible: true
kinetic law: MODEL1310110059#

metaR C142CPT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_d61e723b_a23b_4fcd_bc89_561848cf7352
has only substance units: false
name: SDR16C5
is encoded by: hsa:195814
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: B3KT84
is: SBO:0000252
boundary condition: true

metaR FAOXC142C122x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaM taur e
constant: false
is: HMDB00251
is: CHEBI:3544
is: C00245
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
boundary condition: false
has only substance units: false
type: Species
name: Taurine
is: SBO:0000247

metaR HTDCACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR GALtly
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110059#
is described by: ECO:0000000
fast: false
name: galactose efflux from lysosome
reversible: false
is: SBO:0000185
product: MODEL1310110059#

metaR M4MPDOL Lter
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: m4mpdol flippase
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaR SUCD1m
fast: false
is: SBO:0000176
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
type: Reaction
product: MODEL1310110059#
name: succinate dehydrogenase
is version of: http://identifiers.org/ec-code/1.3.5.1
modifier: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
is described by: ECO:0000134

metaR HEX7
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000304
kinetic law: MODEL1310110059#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
name: hexokinase (D-fructose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_001f740a_3403_43fa_8682_27bc614c6d29
is encoded by: hsa:3284
initial amount: NaN
initial concentration: NaN
constant: false
name: HSD3B2
has only substance units: false
type: Species
boundary condition: true
is: P26439
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_0b99f527_3c80_4a70_a2cc_5868f5c3bc24
initial amount: NaN
is encoded by: hsa:2348
name: FOLR1
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaM inost e
is: SBO:0000247
has only substance units: false
name: myo-inositol
constant: false
initial amount: NaN
is: HMDB00211
type: Species
boundary condition: false
is: CHEBI:17268
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_864c920f_91bd_4fa2_8e96_11303ae8545c
name: ADH1A:ADH1B
is encoded by: hsa:124
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
has part: P07327
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110059#_53caef6e_4d83_4b00_a58a_42ceba9ff717
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4645
name: MYO5B
boundary condition: true
type: Species
constant: false
is: Q9H6Y6
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_6e82c833_fad6_420c_be0f_15f2911a551a
constant: false
boundary condition: true
is: P30043
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: BLVRB
has only substance units: false
is encoded by: hsa:645

metaM CE4876 r
name: delta12-Prostaglandin J2
constant: false
type: Species
is: CHEBI:57923
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_72e68f88_b118_47cf_9a04_d720630fe000
initial concentration: NaN
constant: false
initial amount: NaN
is: P35558
name: PCK1
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:5105
has only substance units: false

metaM m6mpdol L r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
is: CHEBI:37635
is: SBO:0000247
constant: false
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20

metaR STRDNCCRNt
product: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM dhcholestanate x
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: SBO:0000247
is: HMDB00359
constant: false
boundary condition: false

metaR r0590
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110059#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reversible: false
reactant: MODEL1310110059#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3

metaR FAOXC164GC163m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaM ksii core4 pre8 g
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00175
constant: false
is: CHEBI:58053
is: SBO:0000247
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: C00130
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8
has only substance units: false

metaR FAOXC164C143x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaR 3DSPHR
type: Reaction
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.102
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
name: 3-Dehydrosphinganine reductase
product: MODEL1310110059#

metaR APOC LYS BTNPm
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
name: proteolysis of apoC-Lys-btn, mitochondrial
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_a7e12c7a_6029_46a9_9485_d561b0d5a71b
has only substance units: false
boundary condition: true
is encoded by: hsa:7108
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: TM7SF2
is: O76062
constant: false

metaM adp x
is: CHEBI:456216
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
initial concentration: 1.0
name: ADP(3-)
is: HMDB01341
has only substance units: false
initial amount: NaN
constant: false

metaR GLCNACPT L
reversible: false
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.8.15
is: SBO:0000176
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR ARACHDCOAtx
is: SBO:0000185
name: fatty acid intracellular transport
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_26392586_0e2e_4a78_be7d_3ac80019529c
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: _83530_1_c
has only substance units: false
boundary condition: true
is encoded by: hsa:83530

metaM hs deg2 l
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 2
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB06210
notes: FORMULA: C79H116N5O96S10 CHARGE: -11

http://identifiers.org/biomodels.db/MODEL1310110059#_4d7c9079_4a29_48bd_9390_5eaffdfc849e
is: E7EPT3
type: Species
initial amount: NaN
has only substance units: false
name: ALDH7A1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:501
constant: false
boundary condition: true

metaM gbside hs g
is: SBO:0000247
constant: false
initial concentration: 1.0
name: globoside
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_0eb01c2d_2091_4b11_8f4c_959e7aa7c173
boundary condition: true
name: AUH
is: Q13825
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:549
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_2523aabd_86cc_4aa1_be5b_9eebec8a8722
constant: false
name: AMACR
type: Species
is: Q3KT79
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23600
boundary condition: true
is: SBO:0000252

metaM ocdcea e
is: C00712
constant: false
is: HMDB00207
name: octadecenoate (n-C18:1)
is: CHEBI:0
type: Species
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR C16OHc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_436cfbdc_038a_4dca_905a_9ff3eb944025
type: Species
name: OCRL
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:4952
has only substance units: false

metaM ksi pre24 g
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 24
is: CHEBI:58053
is: HMDB00175
boundary condition: false
is: C00130

metaR ACACT1x
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#

metaR RE2541E
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
name: RE2541
type: Reaction
product: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_dd352727_50e1_47ec_994f_a7d1472df7ec
constant: false
initial amount: NaN
name: AMT
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P48728
has only substance units: false
is encoded by: hsa:275
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_1766df37_fccf_4e3a_be31_f142bcf32b5d
is encoded by: hsa:3658
initial concentration: NaN
constant: false
has only substance units: false
name: IREB2
type: Species
boundary condition: true
is: P48200
initial amount: NaN
is: SBO:0000252

metaM dmhptcrn e
has only substance units: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
is: SBO:0000247
name: 2,6 dimethylheptanoyl carnitine
initial concentration: 1.0
type: Species
is: HMDB06320
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_5235a2d4_6609_4776_b196_6aaa39e593f1
initial amount: NaN
name: SUCLG1
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8802
initial concentration: NaN
is: P53597

http://identifiers.org/biomodels.db/MODEL1310110059#_bdb73362_bfe3_4390_9d44_052fe7e47c0e
name: PLCG2
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:5336
is: P16885

http://identifiers.org/biomodels.db/MODEL1310110059#_47d56fcd_666b_4a01_b6bb_1a7412dd8a19
boundary condition: true
is encoded by: hsa:5141
type: Species
is: P27815
constant: false
is: SBO:0000252
has only substance units: false
name: PDE4A
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_b56d450f_71af_4598_8271_fdcd8b50153d
is encoded by: hsa:51227
is encoded by: hsa:5279
is: SBO:0000297
has part: Q14442
type: Species
has part: B3KUV7
has part: Q9BRB3
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:9091
is encoded by: hsa:5283
boundary condition: true
has part: O94777
has part: Q92535
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5277
is encoded by: hsa:8818

metaM thr L e
initial amount: NaN
is: HMDB00167
is: CHEBI:16857
boundary condition: false
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: L-threonine

metaR ACOAD9m
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110059#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110059#
fast: false
is described by: ECO:0000269

metaM pydx c
initial amount: NaN
is: SBO:0000247
name: Pyridoxal
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01545
boundary condition: false
is: C00250
type: Species
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: CHEBI:17310

metaR ARACHCOAtx
fast: false
name: fatty acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
reversible: true
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110059#_687f1ba6_2add_4bd8_91b1_241379c577f4
initial concentration: NaN
name: GLS2
type: Species
constant: false
is encoded by: hsa:27165
is: Q9UI32
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM ocdcea c
initial concentration: 1.0
is: C00712
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: HMDB00207
name: octadecenoate (n-C18:1)
is: CHEBI:0
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_0b9f67fe_5bdc_4269_9717_08cd5443b39b
constant: false
initial amount: NaN
boundary condition: true
name: NDUFB11
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9NX14
is encoded by: hsa:54539

metaM 4hbz m
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
name: 4-hydroxybenzoate
is: CHEBI:17879
is: HMDB00500

metaM asp L e
is: HMDB00191
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
name: L-aspartate(1-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: CHEBI:29991

http://identifiers.org/biomodels.db/MODEL1310110059#_20860dc6_aa3c_476d_bdfe_da87fe7360a8
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q8TCG5
name: CPT1C
is encoded by: hsa:126129
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM 3hmp m
initial amount: NaN
type: Species
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoate
is: CHEBI:11805
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: HMDB00023

metaM glcur r
initial concentration: 1.0
is: HMDB00127
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
name: D-glucuronate
is: SBO:0000247
constant: false
is: CHEBI:15748
boundary condition: false

metaR P5CDm
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
reversible: false
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

metaR r0016
notes: GENE_ASSOCIATION: (1356.1) or (2495.1) or (2509.1) or (94033.1) or (84343.1) SUBSYSTEM: Miscellaneous EC Number: 1.16.3.1 Confidence Level: 0 AUTHORS: PMID:16405854,PMID:2154449,PMID:9162052,PMID:9722559 NOTES:
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
is: SBO:0000176
name: Fe(II):oxygen oxidoreductase Porphyrin and chlorophyll metabolism EC:1.16.3.1
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.16.3.1

metaM ac m
constant: false
name: acetate
is: CHEBI:30089
initial concentration: 1.0
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00042

metaM arachdcoa m
boundary condition: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
is: SBO:0000247
is: HMDB06523
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM dmhptcrn c
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: 2,6 dimethylheptanoyl carnitine
initial concentration: 1.0
boundary condition: false
is: HMDB06320
has only substance units: false

metaR NAGA2ly
is version of: http://identifiers.org/ec-code/3.2.1.49
fast: false
reversible: false
kinetic law: MODEL1310110059#
name: N-acetylgalactosaminidase, alpha-
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
type: Reaction
product: MODEL1310110059#
is: SBO:0000176

metaR HBZOPT10m
modifier: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.39
name: Hydroxybenzoate Decaprenyltransferase
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
reactant: MODEL1310110059#
is described by: ECO:0000269
reversible: false

metaR MALTt1r
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
fast: false
type: Reaction
name: maltose transport (uniport)
modifier: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true

metaM hexe3coa m
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB06522
name: 3-hexenoylcoa
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
boundary condition: false

metaR ACACT1r
product: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110059#
name: acetyl-CoA C-acetyltransferase
fast: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
kinetic law: MODEL1310110059#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110059#

metaR FAOXC102C81m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaM adrncrn c
name: Adrenyl carnitine
has only substance units: false
is: SBO:0000247
is: HMDB00062
initial amount: NaN
initial concentration: 1.0
is: C00318
boundary condition: false
is: CHEBI:16347
type: Species
constant: false
notes: FORMULA: C29H49NO4 CHARGE: 0

metaR C141OHc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

metaM ksi deg24 l
boundary condition: false
is: SBO:0000247
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00143
name: keratan sulfate I, degradation product 24
type: Species
is: CHEBI:12936
initial concentration: 1.0

metaR S23T3g
is described by: ECO:0000000
product: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.99.6
reversible: false
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
modifier: MODEL1310110059#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD

metaM hdd2crn c
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
type: Species
constant: false
is: HMDB06317
boundary condition: false
initial concentration: 1.0
name: trans-Hexadec-2-enoyl carnitine

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR RE3242R
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110059#
reversible: true
type: Reaction
fast: false
name: RE3242
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#

metaM vacc c
name: trans-vaccenate
is: C08367
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: CHEBI:30828
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_6bcb70d2_fd32_46cb_b371_69aea1eadfa4
initial concentration: NaN
boundary condition: true
is: B7Z723
name: LIPF
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:8513
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_3bc3e284_0590_4411_83f4_7dfc95ba2375
initial amount: NaN
boundary condition: true
name: COX6B1
type: Species
is encoded by: hsa:1340
initial concentration: NaN
is: SBO:0000252
is: P14854
has only substance units: false
constant: false

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaR CLFORtex
is: SBO:0000185
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000304
product: MODEL1310110059#
name: chloride transport via formate countertransport
type: Reaction
reversible: false
modifier: MODEL1310110059#

metaM ibcoa m
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
boundary condition: false
is: CHEBI:57338
name: isobutyryl-CoA(4-)
is: HMDB01243
constant: false
has only substance units: false
initial amount: NaN

metaR RPE
is described by: ECO:0000000
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
name: ribulose 5-phosphate 3-epimerase
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/5.1.3.1
reversible: true
is: SBO:0000176

metaR GLACter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: true
fast: false
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum

metaR 3MOBt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
fast: false
reversible: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
is: SBO:0000185

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM aacoa x
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
has only substance units: false
type: Species
is: HMDB01484
name: acetoacetyl-CoA(4-)
is: CHEBI:57286
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_a6e62fd5_1e74_4aa8_98ba_1fed06c0d8b1
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: ADSSL1
is: SBO:0000252
is: Q8N142
is encoded by: hsa:122622
initial amount: NaN
has only substance units: false

metaR FAS140COA
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110059#
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110059#
name: fatty-acyl-CoA synthase (n-C14:0CoA)
is version of: http://identifiers.org/ec-code/2.3.1.85

http://identifiers.org/biomodels.db/MODEL1310110059#_e5424d50_0a54_44a4_94e7_8e23c0ef5a4c
initial amount: NaN
type: Species
initial concentration: NaN
name: NDUFA9
is encoded by: hsa:4704
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: Q16795

metaM fol m
initial amount: NaN
is: CHEBI:27470
is: HMDB00121
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
has only substance units: false
constant: false
type: Species
name: Folate
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_424f18cc_5106_4518_97b3_530644e6e610
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: _W87865_1_c
boundary condition: true
is encoded by: hsa:W87865

metaR C226COAtx
type: Reaction
reactant: MODEL1310110059#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110059#
name: fatty acid intracellular transport
product: MODEL1310110059#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_a71a529e_818b_4c96_b9e1_0ff899c4e08d
is encoded by: hsa:23428
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000297
has part: Q86U05
type: Species
name: SLC7A8:SLC3A2
has only substance units: false

metaR SO4tl
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
name: Sulfate transport (lysosome)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_956f9b7a_e4ea_46f3_9837_f87bdfa8f0a0
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA419122
name: _AA419122_1_c

metaR CYSTGLUex
reversible: false
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
type: Reaction
kinetic law: MODEL1310110059#
name: L-cystine/L-glutamate exchanger
fast: false
is described by: ECO:0000269
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#

metaR PRPNCOAHYDm
product: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.18
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
name: Propenoyl-CoA hydrolase (m)
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_09ec6c5e_d309_4f20_9081_d069bf10c265
is: P48735
is: SBO:0000252
is encoded by: hsa:3418
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: IDH2

http://identifiers.org/biomodels.db/MODEL1310110059#_7f651c08_00d3_4f53_a644_e68e1e726d18
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6470
boundary condition: true
constant: false
type: Species
name: SHMT1
is: SBO:0000252
initial amount: NaN

metaR FBA2
reversible: true
reactant: MODEL1310110059#
is described by: ECO:0000304
kinetic law: MODEL1310110059#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110059#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_9fecda23_b491_4fef_afdc_5d2a027a32d4
has only substance units: false
name: RBAK
constant: false
is encoded by: hsa:57786
is: Q9NYW8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaR INSTt4 2
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
reactant: MODEL1310110059#
reversible: true
product: MODEL1310110059#
fast: false
type: Reaction
name: inositol transport via sodium symport
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185

metaM ksi pre30 g
is: CHEBI:58053
initial concentration: 1.0
is: HMDB00175
type: Species
constant: false
initial amount: NaN
is: C00130
is: SBO:0000247
boundary condition: false
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 30

metaM HC01610 e
is: CHEBI:28607
is: SBO:0000247
initial amount: NaN
name: CoproporphyrinogenI
constant: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_e31f6942_0df4_4596_b945_4f993f28367f
is encoded by: hsa:9058
initial amount: NaN
has only substance units: false
constant: false
name: SLC13A2
type: Species
is: SBO:0000252
is: E7ETH5
boundary condition: true
initial concentration: NaN

metaM aacoa m
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01484
constant: false
name: acetoacetyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
is: CHEBI:57286
type: Species

metaM lac D c
type: Species
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
constant: false
initial amount: NaN
name: (R)-lactate
initial concentration: 1.0
has only substance units: false
is: CHEBI:16004
is: SBO:0000247
is: HMDB01311

metaM 44mzym r
constant: false
initial amount: NaN
is: CHEBI:18364
has only substance units: false
is: SBO:0000247
is: HMDB01286
type: Species
name: 14-demethyllanosterol
boundary condition: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial concentration: 1.0

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM 2mpdhl m
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17577
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false
is: SBO:0000247
name: S-(2-Methylpropanoyl)-dihydrolipoamide
type: Species

metaM pail34p hs c
initial amount: NaN
boundary condition: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
constant: false
has only substance units: false
is: CHEBI:57658
initial concentration: 1.0

metaR PTPATe
is: SBO:0000176
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
name: PTPATe
product: MODEL1310110059#

metaR r2344
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_0e3e8dad_64e7_4eb1_a448_17e49216769d
name: SC5DL
is encoded by: hsa:6309
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q6GTM5

http://identifiers.org/biomodels.db/MODEL1310110059#_ac2acab8_324e_4adf_af1a_0d4e3f1fd320
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:215
constant: false
boundary condition: true
name: ABCD1
is: P33897
has only substance units: false

metaM glcur l
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
has only substance units: false
constant: false
is: HMDB00127
is: CHEBI:15748
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_e7c28aba_6ada_446d_9800_2a440ed14ed4
is: P08842
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: STS
boundary condition: true
is encoded by: hsa:412
constant: false

metaM hs deg9 l
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
name: heparan sulfate, degradation product 9
initial concentration: 1.0
constant: false
is: CHEBI:18268
is: HMDB06355
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

metaR KCCt
is described by: ECO:0000269
type: Reaction
name: K+-Cl- cotransport
is: SBO:0000185
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD

metaM acgpail hs c
has only substance units: false
initial amount: NaN
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57265
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288

http://identifiers.org/biomodels.db/MODEL1310110059#_283177d7_6f96_4d2f_beea_ef536ee18b48
initial amount: NaN
name: NDUFA3
boundary condition: true
is: O95167
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4696
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_6e315745_4424_4484_84e8_7485f4855dcf
is: O14975
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC27A2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:11001

http://identifiers.org/biomodels.db/MODEL1310110059#_dac401e7_442c_4adc_991f_130f15dc5545
initial concentration: NaN
initial amount: NaN
type: Species
name: ADCY2
boundary condition: true
is: Q71UM8
is: SBO:0000252
constant: false
is encoded by: hsa:108
has only substance units: false

metaR CORE4GTg
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
modifier: MODEL1310110059#
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.102
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110059#

metaR PEt
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reactant: MODEL1310110059#
name: phosphatidylethanolamine transport
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_dbacdaef_e6e2_4f60_a418_19667e9c1d96
boundary condition: true
is: SBO:0000252
constant: false
name: ABCB4
is encoded by: hsa:5244
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR ACGALK
reactant: MODEL1310110059#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
name: N-acetylgalactosamine kinase
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_0b891730_63d0_41d7_8ace_72a834539cc4
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _LOC728997_1_c
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:LOC728997

metaM ac c
is: SBO:0000247
constant: false
name: acetate
has only substance units: false
initial amount: NaN
is: CHEBI:30089
initial concentration: 1.0
is: HMDB00042
boundary condition: false
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaR C4tmc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_47308e6f_4fd4_481e_b50b_5267f3b280db
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80347
is: SBO:0000252
name: COASY
boundary condition: true
constant: false
type: Species
is: Q13057
initial amount: NaN

metaR FACOAL1831
reversible: true
product: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110059#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269

metaR LEUKTRE4t
type: Reaction
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene E4 transport
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185

metaR MALtm
name: malate transport, mitochondrial
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
fast: false
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
product: MODEL1310110059#

metaR r2341
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110059#
fast: false
is: SBO:0000185
reactant: MODEL1310110059#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110059#

metaR FAOXC5C5DCc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaM dmhptcrn m
boundary condition: false
name: 2,6 dimethylheptanoyl carnitine
is: HMDB06320
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3

metaM m8mpdol L r
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:59093
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_330d82ea_49d3_462d_84d4_8892897b8a0a
name: PDE2A
is encoded by: hsa:5138
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q8IW54
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_38b3e17d_9e23_478e_90ea_994ebf1fad1f
constant: false
name: B3GALNT1
initial amount: NaN
initial concentration: NaN
is: B3KTQ4
type: Species
is encoded by: hsa:8706
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ca1c0c9e_ba06_432c_b97a_69a5d0e18531
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: _N63787_1_c
has only substance units: false
is encoded by: hsa:N63787

metaR RPI
reactant: MODEL1310110059#
fast: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/5.3.1.6
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
name: ribose-5-phosphate isomerase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_6646e107_e311_44b1_b2f4_8415c7ab5f1b
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
name: _AA788780_1_c
is encoded by: hsa:AA788780
is: SBO:0000252

metaR r2342
is: SBO:0000185
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110059#
type: Reaction

metaM vacc e
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30828
constant: false
type: Species
name: trans-vaccenate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1b279381_c6b3_44d8_ba09_810bcd3c0113
is: SBO:0000252
boundary condition: true
is: E9PCI1
initial concentration: NaN
type: Species
name: ACP2
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:53

metaR AKGtp
type: Reaction
name: AKG transporter, peroxisome
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110059#

metaM asp L m
initial concentration: 1.0
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
is: CHEBI:29991
boundary condition: false
is: SBO:0000247
is: HMDB00191
name: L-aspartate(1-)
type: Species
initial amount: NaN

metaR FACOAL1832
modifier: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
name: fatty-acid--CoA ligase
is described by: ECO:0000269
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C

metaM gsn c
is: SBO:0000247
is: C00387
type: Species
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: Guanosine
is: CHEBI:16750
is: HMDB00133
constant: false
boundary condition: false

metaM hmgcoa c
is: CHEBI:15467
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
is: HMDB01375

metaR INSTt4
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
product: MODEL1310110059#
name: inositol transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110059#_d201c05d_5941_43e2_a281_09b9b517e67e
is: F8WDN9
name: PPA2
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:27068

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaR C141OHe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR HAtly
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: hyaluronan transport, extracellular to lysosome
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_c55ae919_5820_4d2f_aa35_547cf34aeb42
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3033
boundary condition: true
name: HADH
has only substance units: false
is: Q16836
type: Species
initial concentration: NaN

metaR FAOXC164C143m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_c7545ffc_8796_44c9_8d0c_129145698753
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: Q9BRB3
is encoded by: hsa:9091
boundary condition: true
name: PIGQ

http://identifiers.org/biomodels.db/MODEL1310110059#_3ed26c94_ce5e_480b_a93f_ea1685ee6fdf
constant: false
initial amount: NaN
is: Q9BZQ4
has only substance units: false
is encoded by: hsa:23057
boundary condition: true
is: SBO:0000252
name: NMNAT2
type: Species
initial concentration: NaN

metaR SO4HCOtex
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
name: sulfate transport via bicarbonate countertransport
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#

metaM ac e
has only substance units: false
is: CHEBI:30089
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
constant: false
name: acetate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM itaccoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: HMDB03377
name: itaconyl-CoA(5-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:57381
initial concentration: 1.0
boundary condition: false

metaR FACOAL181i
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reversible: false
type: Reaction
modifier: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110059#
name: C181 fatty acid activation

metaR NACHEX19ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
is: SBO:0000176
fast: false
name: beta-N-acetylhexosaminidase, lysosomal

metaR r1859
reversible: false
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110059#

metaM fol c
has only substance units: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00121
constant: false
boundary condition: false
initial concentration: 1.0

metaR A MANASEly
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.24
fast: false
reactant: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
reversible: false
name: alpha-mannosidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD

metaM 2ddecdicoa m
type: Species
boundary condition: false
is: HMDB11123
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: 2,6-dodecadienoylcoa
is: C05279
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110059#_e51fefc0_06f0_4786_b8bc_002602b3f9db
boundary condition: true
name: TXNRD1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7296
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaR r0480
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110059#
is: SBO:0000176
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110059#

metaM ksi pre6 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 6
is: CHEBI:58053
initial amount: NaN
notes: FORMULA: C107H174N7O80SX CHARGE: -2
constant: false
type: Species
boundary condition: false
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247
is: C00130

metaR r1538
product: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
is: SBO:0000185
name: Anion Exchanger (AE) TCDB:2.A.31.2.8

http://identifiers.org/biomodels.db/MODEL1310110059#_6aca5fb5_35db_4511_8307_8b702d133b41
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:81539
initial amount: NaN
initial concentration: NaN
name: SLC38A1
constant: false
is: Q9H2H9
has only substance units: false

metaR BILIRUBt2
is: SBO:0000185
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
name: bilirubin transport via bicarbonate countertransport
reversible: true
product: MODEL1310110059#
is described by: ECO:0000269

metaR r0603
reversible: true
type: Reaction
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.12
is: SBO:0000176
product: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000

metaR KYNAKGAT
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.64
name: L-Kynurenine:2-oxoglutarate aminotransferase
type: Reaction
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is: SBO:0000176
product: MODEL1310110059#
is described by: ECO:0000269
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#

metaM cs a deg2 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
initial concentration: 1.0
type: Species
is: HMDB00127
has only substance units: false
is: CHEBI:15748
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_10646601_b61f_4603_8a8a_7ec18f2a52eb
initial concentration: NaN
initial amount: NaN
has part: P27986
constant: false
is encoded by: hsa:5295
boundary condition: true
has only substance units: false
name: PIK3CA:PIK3R1
is: SBO:0000297
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_4e53df73_d4d4_46d6_a114_509a51a3f841
is: SBO:0000252
is: Q01415
type: Species
initial amount: NaN
name: GALK2
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:2585

http://identifiers.org/biomodels.db/MODEL1310110059#_a5834798_9607_450f_bdc7_ab283ac7ce59
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1103
name: CHAT
boundary condition: true
constant: false
has only substance units: false
is: Q6LEN6

http://identifiers.org/biomodels.db/MODEL1310110059#_db48afdd_1c13_415c_bcb8_d3b36e897a74
is: SBO:0000252
is encoded by: hsa:4597
constant: false
initial concentration: NaN
initial amount: NaN
is: P53602
name: MVD
boundary condition: true
has only substance units: false
type: Species

metaR DSAT
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: dihydrosphingosine N-acyltransferase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_624a8aac_f807_4399_8a4f_043b6ede95a2
has only substance units: false
is encoded by: hsa:22305
constant: false
initial amount: NaN
name: _22305_1_c
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_58a26e02_1149_456e_9fe4_cbebc28308e7
is: Q96CA6
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: ACAA1
is encoded by: hsa:30
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_3e582d2f_e60c_43dd_a2b4_6993041c0504
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:5151
is: SBO:0000252
name: PDE8A
boundary condition: true
initial concentration: NaN
type: Species

metaR RE1796M
fast: false
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.145
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is: SBO:0000176
name: RE1796
product: MODEL1310110059#
reactant: MODEL1310110059#

metaR FBA4
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
reversible: true
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_b24f1eb4_eabb_4e48_aaac_f738e81d070f
type: Species
has only substance units: false
name: CTH
boundary condition: true
is encoded by: hsa:1491
constant: false
initial concentration: NaN
is: SBO:0000252
is: P32929
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_5c4eb55e_4bdd_4a68_8370_8764deab21ae
constant: false
boundary condition: true
is: Q07837
is encoded by: hsa:6519
type: Species
initial concentration: NaN
has only substance units: false
name: SLC3A1
initial amount: NaN
is: SBO:0000252

metaM fol e
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
has only substance units: false
name: Folate
is: HMDB00121
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

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has part: E9PDD5
initial amount: NaN
is encoded by: hsa:3421
is encoded by: hsa:3420
is: SBO:0000297
constant: false
name: IDH3A:IDH3B:IDH3G
has part: P50213
boundary condition: true
is encoded by: hsa:3419
initial concentration: NaN
type: Species
has only substance units: false

metaM inost c
constant: false
initial amount: NaN
name: myo-inositol
is: CHEBI:17268
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_26b81089_f1b5_4a2e_bbbe_006a7f75ebad
constant: false
is encoded by: hsa:5153
name: PDE1B
type: Species
is: SBO:0000252
is: Q7Z364
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR DDECE1CRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaR FAOXC163GC142m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR r2014
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
modifier: MODEL1310110059#
product: MODEL1310110059#
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a4e2b44a_480f_4109_bcde_39e1cf18667d
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P28332
is: SBO:0000252
boundary condition: true
constant: false
name: ADH6
type: Species
is encoded by: hsa:130

metaM m5mpdol L r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:37634
constant: false
boundary condition: false
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
type: Species

metaR FAOXC61C4x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaR C161CPT22
reactant: MODEL1310110059#
fast: false
is: SBO:0000176
name: C161 transport into the mitochondria
is described by: ECO:0000269
product: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_d53c0b67_28c1_4026_ae74_353c07d60522
name: SLC38A3
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10991
is: Q99624
boundary condition: true
constant: false
type: Species

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_86de03e3_8fb1_4bb3_a78a_90c1f22cf109
constant: false
boundary condition: true
name: NDUFB6
has only substance units: false
is: O95139
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4712
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_2f71fc01_4054_4047_9441_3c63d7d0ccb4
is encoded by: hsa:51005
is: Q9Y303
has only substance units: false
type: Species
name: AMDHD2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaM hxan e
is: HMDB00157
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: CHEBI:17368
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial concentration: 1.0
name: hypoxanthine
is: SBO:0000247

metaR r2322
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110059#
fast: false
product: MODEL1310110059#

metaM sgalside hs l
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:16349
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
is: HMDB00904

http://identifiers.org/biomodels.db/MODEL1310110059#_c799e85e_4be5_4701_834d_f06d91d80615
name: BAAT
is: Q14032
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:570
constant: false
initial concentration: NaN

metaR EX c10crn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

metaM 5tedtricoa m
boundary condition: false
initial amount: NaN
name: 5,8,11-tetradecatrienoylcoa
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: HMDB02288
initial concentration: 1.0

metaR SUCCTD
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a04cb94a_9a82_4a58_9f63_ef601075eceb
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:5631
is: P60891
initial amount: NaN
constant: false
name: PRPS1
boundary condition: true

metaR S6TASE17ly
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
reversible: true
product: MODEL1310110059#
type: Reaction

metaM aprgstrn c
name: (20S)-20-hydroxypregn-4-en-3-one
is: CHEBI:28453
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
is: HMDB03069

metaM sucsal m
type: Species
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
initial concentration: 1.0
boundary condition: false
is: CHEBI:57706
is: HMDB01259
constant: false
initial amount: NaN
name: Succinic semialdehyde
has only substance units: false

metaR PRFGS
reactant: MODEL1310110059#
is: SBO:0000176
name: phosphoribosylformylglycinamidine synthase
reversible: false
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.3
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_19382c87_472d_4146_98bc_7ff112c63af1
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q16773
type: Species
boundary condition: true
name: CCBL1
constant: false
is: SBO:0000252
is encoded by: hsa:883

http://identifiers.org/biomodels.db/MODEL1310110059#_4febea19_4b18_42d2_99a4_58ca75491ada
type: Species
is: SBO:0000252
initial concentration: NaN
is: A4D1D5
boundary condition: true
has only substance units: false
name: ABCB4
is encoded by: hsa:5244
initial amount: NaN
constant: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR r2321
is described by: ECO:0000000
product: MODEL1310110059#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110059#

metaM glu5sa m
initial amount: NaN
is: SBO:0000247
is: C01165
boundary condition: false
is: HMDB02104
initial concentration: 1.0
name: L-Glutamate 5-semialdehyde
type: Species
has only substance units: false
is: CHEBI:17232
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165

metaM ps hs c
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: ps_hs[c]
initial concentration: 1.0
is: CHEBI:18303
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR RE0926E
type: Reaction
is described by: ECO:0000000
name: RE0926
reversible: true
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
modifier: MODEL1310110059#

metaM ksi deg40 l
is: CHEBI:12936
is: HMDB00143
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C40H68N2O31 CHARGE: 0
name: keratan sulfate I, degradation product 40
initial amount: NaN
has only substance units: false

metaM decdicoa c
name: decadienoylcoa
constant: false
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: HMDB01168
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_9f275a60_945d_4bcf_abc5_6c14a87d4e64
type: Species
name: B3GNT2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10678
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR TCYNTt
reversible: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
product: MODEL1310110059#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM

metaM trdrd m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
constant: false
type: Species
has only substance units: false

metaM pail3p hs c
is: CHEBI:58088
type: Species
constant: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
is: SBO:0000247

metaR SPRMTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.
name: absorption for spermine across the basolateral side
reversible: true
type: Reaction
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110059#
kinetic law: MODEL1310110059#

metaM lac D e
constant: false
is: HMDB01311
is: CHEBI:16004
name: (R)-lactate
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM adn e
has only substance units: false
is: C00212
boundary condition: false
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
name: Adenosine
is: HMDB00050
is: CHEBI:16335

http://identifiers.org/biomodels.db/MODEL1310110059#_e9cd2051_7ab9_489c_9f85_b3c19e8b6de9
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:60482
initial amount: NaN
name: SLC5A7
is: Q9GZV3
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM hxan c
is: SBO:0000247
is: HMDB00157
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:17368
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: C00262
name: Hypoxanthine
boundary condition: false
has only substance units: false

metaM pre prot r
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: glycophosphatidylinositol (GPI)-anchored protein precursor
type: Species
notes: FORMULA: XY CHARGE: 0
constant: false
is: HMDB03125
initial concentration: 1.0
is: CHEBI:16240
has only substance units: false

metaR r2324
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
reactant: MODEL1310110059#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_a158042c_f707_4a0d_a814_f825b2c1ce18
initial concentration: NaN
is encoded by: hsa:8818
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5277
boundary condition: true
is: SBO:0000297
constant: false
has part: P37287
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_4bbb4311_16db_4ce2_86e9_c86d41ae86c6
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: PRPS1L1
initial amount: NaN
constant: false
is encoded by: hsa:221823
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_92403a04_8832_42e1_b628_7c748d76ab2b
is encoded by: hsa:5230
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: P00558
name: PGK1

http://identifiers.org/biomodels.db/MODEL1310110059#_c9405b7b_da25_42a8_bd95_45abd152d6c9
initial concentration: NaN
name: GALNT5
is: SBO:0000252
initial amount: NaN
is: A5PKZ1
is encoded by: hsa:11227
boundary condition: true
type: Species
has only substance units: false
constant: false

metaM ddece1crn c
boundary condition: false
initial amount: NaN
type: Species
is: HMDB03712
notes: FORMULA: C19H35NO4 CHARGE: 0
initial concentration: 1.0
name: dodecenoyl carnitine
constant: false
is: SBO:0000247
has only substance units: false

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_6e9d78ab_f25b_4839_a679_1359118f30b9
is: SBO:0000252
initial concentration: NaN
type: Species
name: TALDO1
initial amount: NaN
is encoded by: hsa:6888
is: P37837
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_894c1432_6499_4835_aa2f_4668a7b9cda7
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: CYP11A1
is encoded by: hsa:1583
is: G3XAD7
constant: false
has only substance units: false

metaR r2323
product: MODEL1310110059#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110059#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_146868d8_a772_4e5f_ba08_625198058571
is encoded by: hsa:522
initial amount: NaN
name: ATP5J
initial concentration: NaN
type: Species
is: Q6IB54
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaM m2gacpail hs r
type: Species
has only substance units: false
is: SBO:0000247
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16038
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110059#_ea6f27e0_196b_4d1d_b898_a20a5d6fbebc
name: UCK1
boundary condition: true
is encoded by: hsa:83549
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: Q5JT09
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_4ef6b4cd_4816_48e0_a9f5_a36da29e6772
name: SLC9A5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6553
initial amount: NaN
is: SBO:0000252
is: Q9NSW9
constant: false
type: Species
boundary condition: true

metaM dem2emgacpail prot hs r
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16311
is: HMDB00998
type: Species
constant: false
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
initial amount: NaN
boundary condition: false
is: C00458
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1611847b_2d04_4a53_aa33_b0a731a926d6
initial amount: NaN
type: Species
is: P39656
boundary condition: true
name: DDOST
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:1650

http://identifiers.org/biomodels.db/MODEL1310110059#_7da83276_3d7f_4ba2_a755_07ef3fca28f5
constant: false
type: Species
is: Q8N1Q1
is: SBO:0000252
is encoded by: hsa:377677
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: CA13
has only substance units: false

metaM ksi deg23 l
initial concentration: 1.0
is: CHEBI:12936
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: HMDB00143
name: keratan sulfate I, degradation product 23
is: SBO:0000247

metaR FAOXC6C4x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

metaM adn c
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: C00212
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: Adenosine
initial amount: NaN
has only substance units: false
is: HMDB00050
boundary condition: false

metaR TALA
is: SBO:0000176
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.2.1.2
product: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
name: transaldolase
is described by: ECO:0000000

metaM q10 m
name: ubiquinone-10
type: Species
is: CHEBI:46245
is: HMDB01072
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaR FACOAL140i
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
modifier: MODEL1310110059#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
name: fatty-acid--CoA ligase (tetradecanoate)
is described by: ECO:0000269
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_ca444f80_425f_481e_a82a_cf21ef145205
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4842
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: B4DG68
name: NOS1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_173648f4_c2d8_43c2_beee_0cefd284a4b9
is encoded by: hsa:1376
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: CPT2
is: P23786
is: SBO:0000252

metaR r0899
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
is: SBO:0000185
name: Amino acid transporter ATB0+ Facilitated diffusion
reactant: MODEL1310110059#

metaR IVCRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaM C04849 e
initial amount: NaN
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57449
is: SBO:0000247

metaR r2326
is described by: ECO:0000000
product: MODEL1310110059#
type: Reaction
fast: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
reactant: MODEL1310110059#

metaR ABTD
kinetic law: MODEL1310110059#
reversible: true
fast: false
type: Reaction
name: L-arabinitol 4-dehydrogenase
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is: SBO:0000176

metaR C160CRNt
is described by: ECO:0000269
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
modifier: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
name: C160 transport into the mitochondria
reactant: MODEL1310110059#

metaM ddece1crn e
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02250
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C19H35NO4 CHARGE: 0
name: dodecenoyl carnitine
initial concentration: 1.0

metaR ILETAm
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
name: isoleucine transaminase, mitochondrial
modifier: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_a87b5453_206d_4f02_98b6_fef3bbe3e5fe
constant: false
name: PDE8B
initial amount: NaN
has only substance units: false
is: O95263
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8622

metaM clpndcoa c
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205476
constant: false
has only substance units: false
name: clupanodonyl CoA
is: C16166
is: SBO:0000247
initial concentration: 1.0
is: HMDB06267
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial amount: NaN

metaR r1527
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
kinetic law: MODEL1310110059#
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: SBO:0000185
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_cc71ffca_3388_42f8_9d10_d18dc5397ec4
type: Species
is: SBO:0000252
name: DPM2
is encoded by: hsa:8818
initial concentration: NaN
constant: false
is: O94777
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_5366f38a_54a4_4a2a_80a4_1056aca2b02e
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: O75452
is encoded by: hsa:8608
is: SBO:0000252
name: RDH16
type: Species

metaR r2325
type: Reaction
is: SBO:0000185
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

metaM 3mb2coa m
boundary condition: false
is: HMDB01493
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: CHEBI:57344
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: 3-methylbut-2-enoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110059#_ab163722_e9ee_4bc4_b933_17753872d3ce
initial concentration: NaN
has only substance units: false
name: _PRO1933_1_m
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:PRO1933
is: SBO:0000252

metaM 3mob e
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00019
boundary condition: false
name: 3-methyl-2-oxobutanoate
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
constant: false
is: CHEBI:11851

metaR GPIDA2er
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
reversible: false
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_20e027b7_7bd2_43bd_9785_d8df4b2a6938
constant: false
name: UCK2
is encoded by: hsa:7371
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9BZX2
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_30c1e21b_f3f7_4597_bcc7_9b5f85119519
is: SBO:0000252
is: Q549M5
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4718
initial amount: NaN
initial concentration: NaN
name: NDUFC2
constant: false

metaM dgdp c
type: Species
is: C00361
initial concentration: 1.0
boundary condition: false
name: dGDP
initial amount: NaN
has only substance units: false
is: CHEBI:58595
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960

http://identifiers.org/biomodels.db/MODEL1310110059#_56cdd2b5_51f1_49a3_8810_840633971964
is encoded by: hsa:51
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q15067
name: ACOX1
type: Species
boundary condition: true
constant: false

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM succoa m
type: Species
boundary condition: false
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: CHEBI:57292
initial amount: NaN
is: HMDB01022
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Succinyl-CoA

metaR AHEXASE2ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
modifier: MODEL1310110059#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
type: Reaction
fast: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal

metaM CE4872 m
initial concentration: 1.0
is: HMDB00127
constant: false
is: CHEBI:15748
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
has only substance units: false

metaR r0142
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110059#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110059#
type: Reaction
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1

http://identifiers.org/biomodels.db/MODEL1310110059#_a4ae888e_410d_40eb_a811_db5f88a011d8
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000297
initial concentration: NaN
type: Species
has only substance units: false
name: PIK3R5:PIK3CG
is encoded by: hsa:23533
has part: Q8WYR1

http://identifiers.org/biomodels.db/MODEL1310110059#_ef73bf3d_c376_485f_abf8_00ac01cb635b
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5151
constant: false
name: PDE8A
initial concentration: NaN
type: Species

metaM m6masnB2 g
constant: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
type: Species
is: CHEBI:30825
is: HMDB00573
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR r2328
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM i c
initial amount: NaN
boundary condition: false
is: HMDB12238
type: Species
name: iodide
is: CHEBI:16382
initial concentration: 1.0
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
constant: false
is: SBO:0000247

metaR G14T16g
product: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110059#_6f9b09d9_8033_4b0f_9777_7db92dcf52ce
type: Species
is encoded by: hsa:284129
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: SLC26A11
is: SBO:0000252
is: Q86WA9

http://identifiers.org/biomodels.db/MODEL1310110059#_fe2825a1_d6b2_4f1f_ae38_65b6f220acf3
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q14432
is encoded by: hsa:5139
has only substance units: false
type: Species
name: PDE3A

metaR GCALDD
fast: false
type: Reaction
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
name: Glycolaldehyde dehydrogenase
kinetic law: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110059#

metaM btn c
is: HMDB00030
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
is: CHEBI:3420
name: Biotin
constant: false
is: SBO:0000247
type: Species

metaR CSAPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is: SBO:0000176
reversible: false
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)

metaM hexdectecoa m
name: 2,4,7,10-hexadecatetraenoylcoa
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB02288
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN

metaR FE2tm
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
fast: false
reversible: false
reactant: MODEL1310110059#
name: iron (II) transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
is described by: ECO:0000000

metaR IZPN
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110059#
reversible: false
name: Imidazolonepropionase
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_0f37c63e_c653_4b13_8e33_45108f644be5
is encoded by: hsa:1036
type: Species
is: Q16878
boundary condition: true
name: CDO1
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM i e
type: Species
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: iodide
is: HMDB12238

metaM ps hs e
boundary condition: false
constant: false
name: phosphatidylserine
is: CHEBI:18303
initial amount: NaN
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR r2327
product: MODEL1310110059#
reversible: true
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_71753779_9d3a_4a10_8d2f_3a5814e7c63d
name: PCCB
is: P05166
is: SBO:0000252
is encoded by: hsa:5096
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaM 3mob c
is: CHEBI:11851
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00019
boundary condition: false
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
has only substance units: false

metaM sgalside hs g
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:58343
initial amount: NaN
has only substance units: false
is: HMDB00061
name: sulfatide galactocerebroside
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false

metaM retinal cis 9 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
is: SBO:0000247
initial amount: NaN
is: HMDB01358
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:17898
constant: false
boundary condition: false

metaM 6pgc r
is: CHEBI:58759
name: 6-phosphonatooxy-D-gluconate
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
has only substance units: false
is: HMDB01316
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_f578b5e0_fa12_455a_b290_d6d5dc1581be
constant: false
type: Species
is encoded by: hsa:80025
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PANK2
boundary condition: true
has only substance units: false

metaR r1418
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
fast: false
is: SBO:0000176
reactant: MODEL1310110059#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#

metaM nadh r
name: NADH(2-)
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:57945
is: SBO:0000247
is: HMDB01487
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_793b8d44_7deb_4adf_b5a1_002da4b6ee71
is: Q9NQR4
initial amount: NaN
is encoded by: hsa:56954
name: NIT2
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaR PGI
is: SBO:0000176
reversible: true
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
product: MODEL1310110059#
is described by: ECO:0000134
name: glucose-6-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.9
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_22c55461_7d5d_42d0_ba54_0483e48b5385
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:28976
has only substance units: false
is: SBO:0000252
is: Q9H845
name: ACAD9

metaR C161CPT2
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
reversible: false
product: MODEL1310110059#
modifier: MODEL1310110059#
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
is: SBO:0000176
fast: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction

metaM cdp e
is: HMDB01546
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
has only substance units: false
initial amount: NaN
constant: false
name: CDP(3-)
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_4b7f4d7c_c1fc_4b17_9c4f_f1e70e4b4870
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: PANK1
type: Species
has only substance units: false
is encoded by: hsa:53354

metaR r0591
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
fast: false
product: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true

metaR PYK
kinetic law: MODEL1310110059#
reversible: false
name: pyruvate kinase
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110059#
type: Reaction

metaR r2329
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
reversible: true
is described by: ECO:0000000

metaR G12MT1 L
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000

metaR ADNCYC
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
is described by: ECO:0000269
modifier: MODEL1310110059#
fast: false
name: adenylate cyclase
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/4.6.1.1
is: SBO:0000176
reversible: false
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_75c1d59c_1977_476f_8f20_8d662b462490
name: PI4KB
initial amount: NaN
constant: false
is: Q9UBF8
has only substance units: false
is encoded by: hsa:5298
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_e9d1556c_151b_4b9f_94e6_ba011319c24a
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:4701
is: SBO:0000252
is: Q6FG42
name: NDUFA7
initial amount: NaN
boundary condition: true
has only substance units: false

metaR FAOXC6C4m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)m
type: Reaction

metaM 3thexddcoacrn e
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
has only substance units: false
notes: FORMULA: C23H41NO5 CHARGE: 0
is: HMDB02014
boundary condition: false
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
is: SBO:0000247

metaR C161CPT1
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
fast: false
name: production of palmitoleoylcarnitine
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
modifier: MODEL1310110059#
is: SBO:0000176
reversible: false

metaM 3htdcoa m
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA
constant: false
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H58N7O18P3S CHARGE: -4

metaM ksii core2 pre8 g
has only substance units: false
is: HMDB00175
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial concentration: 1.0
is: C00130
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:58053
type: Species

metaR r0594
fast: false
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reactant: MODEL1310110059#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM chol n
name: choline
constant: false
has only substance units: false
is: HMDB00097
is: SBO:0000247
is: CHEBI:15354
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0

metaR GLUPRT
reactant: MODEL1310110059#
reversible: false
name: glutamine phosphoribosyldiphosphate amidotransferase
is version of: http://identifiers.org/ec-code/2.4.2.14
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:

metaM dgdp m
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:58595
name: dGDP(2-)
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960

metaR ALR3
fast: false
name: aldose reductase (acetol)
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
reactant: MODEL1310110059#

metaR PGK
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000134
name: phosphoglycerate kinase
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.2.3

metaR Asn X Ser Thrtr
reactant: MODEL1310110059#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
product: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110059#
fast: false
reversible: true
type: Reaction

metaM cdp c
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
is: HMDB01546
has only substance units: false
is: SBO:0000247
is: CHEBI:58069
is: C00112
initial amount: NaN
name: CDP
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_495066f9_afcb_4f51_a8ef_ab8aacff1f6b
type: Species
has only substance units: false
is encoded by: hsa:2180
is: SBO:0000252
is: P33121
boundary condition: true
constant: false
initial concentration: NaN
name: ACSL1
initial amount: NaN

metaR r0033
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
fast: false
type: Reaction
reversible: false

metaM 2mop m
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
is: CHEBI:57700
boundary condition: false
has only substance units: false
is: HMDB01172
type: Species

metaM lnlncgcrn c
boundary condition: false
is: SBO:0000247
is: HMDB06318
has only substance units: false
name: gamma-linolenyl carnitine
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR LTC4CP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reversible: true
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
name: Leukotriene C4 carboxypeptidase
is described by: ECO:0000000
fast: false

metaR C30CPT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaM asp L c
constant: false
is: CHEBI:29991
is: SBO:0000247
has only substance units: false
name: L-aspartate(1-)
boundary condition: false
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial concentration: 1.0
is: HMDB00191
initial amount: NaN

metaR r1377
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110059#
is: SBO:0000176
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22

metaM dopa c
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
constant: false
is: SBO:0000247
is: HMDB00073
name: dopaminium(1+)
initial concentration: 1.0
is: CHEBI:59905
boundary condition: false

metaR LEUKTRD4t
is: SBO:0000185
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
name: leukotriene D4 transport
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000269

metaR GLNLASEer
product: MODEL1310110059#
reactant: MODEL1310110059#
name: gluconolactonase, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
fast: false
reversible: true
is: SBO:0000176

metaR DOLPMT4 Ler
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
reversible: false
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_daa3c8f6_8cad_4c31_9d45_9f44080dc1fc
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
constant: false
is encoded by: hsa:518
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR ASNSERNaEx
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110059#
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
is described by: ECO:0000269

metaR FAOXC225C204x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_36f4c746_3728_48a0_a625_f918fa8e8e7b
is: SBO:0000252
name: COX1
type: Species
boundary condition: true
is: Q7GXY8
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4512
initial amount: NaN

metaM chol m
initial amount: NaN
type: Species
constant: false
is: CHEBI:15354
boundary condition: false
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
is: HMDB00097
name: choline
is: SBO:0000247

metaM so4 e
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01448

metaM dgdp n
boundary condition: false
is: CHEBI:58595
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: HMDB00960
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP(2-)

metaR ALR2
product: MODEL1310110059#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
name: aldose reductase (methylglyoxal)
is: SBO:0000176

metaR FAOXC225C226m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM dmhptcoa m
boundary condition: false
notes: FORMULA: C30H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C30H52N7O17P3S/c1-17(2)7-6-8-18(3)29(42)58-12-11-32-20(38)9-10-33-27(41)24(40)30(4,5)14-51-57(48,49)54-56(46,47)50-13-19-23(53-55(43,44)45)22(39)28(52-19)37-16-36-21-25(31)34-15-35-26(21)37/h15-19,22-24,28,39-40H,6-14H2,1-5H3,(H,32,38)(H,33,41)(H,46,47)(H,48,49)(H2,31,34,35)(H2,43,44,45)/p-4/t18-,19+,22-,23-,24?,28+/m0/s1
is: HMDB06258
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 2,6 dimethylheptanoyl-CoA
constant: false
is: SBO:0000247

metaR r1378
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284

http://identifiers.org/biomodels.db/MODEL1310110059#_fc927cae_38bb_469e_a33f_84bc2ca2c0b4
is: P36959
is encoded by: hsa:2766
name: GMPR
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaR r0596
reactant: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
product: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_52f37350_a29a_4b65_916c_5904ad4a7c78
constant: false
is encoded by: hsa:6389
initial amount: NaN
type: Species
is: P31040
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SDHA

metaM cspg b e
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial concentration: 1.0
has only substance units: false
is: C00106
boundary condition: false
is: HMDB00300
is: CHEBI:17568
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H65N2O48S4X CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110059#_f57e8ad2_97c9_46cf_9376_7c473bfb0866
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: P80365
initial amount: NaN
name: HSD11B2
is encoded by: hsa:3291

metaR r0443
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110059#
fast: false

metaR RIBt
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
kinetic law: MODEL1310110059#
name: ribose transport via diffusion
product: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
is described by: ECO:0000000

metaR TRDR
reversible: false
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
fast: false
is described by: ECO:0000269
name: thioredoxin reductase (NADPH)
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.8.1.9
type: Reaction
is: SBO:0000176
product: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#

metaR FCLTm
fast: false
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
is described by: ECO:0000304
name: Ferrochelatase, mitochondrial
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.99.1.1
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176
reversible: false
product: MODEL1310110059#
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_63557780_1ada_4b55_bc60_d31fedf9bdc3
name: ADCY6
has only substance units: false
is: O43306
is: SBO:0000252
is encoded by: hsa:112
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR GNDer
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
reversible: false
type: Reaction

metaR FORMCOAtx
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
name: formyl coa transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
fast: false
reactant: MODEL1310110059#
reversible: true

metaR CYTK1m
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000134
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
product: MODEL1310110059#
is: SBO:0000176
name: cytidylate kinase (CMP),mitochondrial
reversible: true

metaM cs e deg5 l
is: CHEBI:57737
notes: FORMULA: C31H47NO35S3 CHARGE: -4
type: Species
initial amount: NaN
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
constant: false
is: HMDB00868
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM gchola x
is: SBO:0000247
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
initial concentration: 1.0
is: CHEBI:58235
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00138
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_8ead0105_6317_463e_80d9_a770954de64d
type: Species
boundary condition: true
is: SBO:0000297
is encoded by: hsa:514
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
constant: false
is encoded by: hsa:513
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM hexdectecoa x
type: Species
constant: false
boundary condition: false
is: HMDB02288
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
name: 2,4,7,10-hexadecatetraenoylcoa
initial concentration: 1.0

metaR FATP8t
reactant: MODEL1310110059#
name: fatty acid electroneutral transport
is: SBO:0000185
type: Reaction
modifier: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110059#
reversible: true
is described by: ECO:0000269

metaR C6COAt
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaM ksi pre25 g
name: keratan sulfate I biosynthesis, precursor 25
has only substance units: false
is: HMDB00175
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: C00130
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:58053
initial concentration: 1.0
type: Species

metaM so4 c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01448
type: Species
name: sulfate
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
is: CHEBI:16189

metaR A4GALTg
reversible: false
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is described by: ECO:0000269
reactant: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.228
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
name: Lactosylceramide 4-alpha-galactosyltransferase
product: MODEL1310110059#
is: SBO:0000176

metaR SEBACIDTD
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaR RE3245C
is described by: ECO:0000000
reversible: true
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
name: RE3245
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton

metaM arach e
type: Species
is: SBO:0000247
name: arachidate
has only substance units: false
is: HMDB02212
initial amount: NaN
constant: false
is: CHEBI:32360
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102

http://identifiers.org/biomodels.db/MODEL1310110059#_4c058347_795e_4620_8f4f_c2ac35e43cc1
is encoded by: hsa:226
constant: false
name: ALDOA
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaR 3DPHBH1
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110059#
fast: false
product: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_2390f03e_1bf4_4c61_8610_448fe3850889
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2629
is: B7Z5G2
type: Species
name: GBA

metaM hs deg22 l
is: SBO:0000247
notes: FORMULA: C37H56NO35S CHARGE: -3
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:21338
has only substance units: false
boundary condition: false
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
is: HMDB02704

metaR CYTK1n
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction

metaM ps hs m
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:18303
name: ps_hs[m]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0

metaM nadh x
is: C00004
boundary condition: false
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
is: CHEBI:57945
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false

metaR CYANtm
kinetic law: MODEL1310110059#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
reactant: MODEL1310110059#
is: SBO:0000185
fast: false
name: Cyanide transport via diffusion (mitochondrial)
is described by: ECO:0000000
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_1989baab_d540_4185_ad77_fa9e2e61db1d
type: Species
name: COX7A2
constant: false
is encoded by: hsa:1347
has only substance units: false
boundary condition: true
initial concentration: NaN
is: H0UI06
initial amount: NaN
is: SBO:0000252

metaM aprgstrn e
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB03069
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
name: (20S)-20-hydroxypregn-4-en-3-one
is: CHEBI:28453
has only substance units: false

metaM gpi sig r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:58190
is: SBO:0000247
boundary condition: false
notes: FORMULA: Y CHARGE: 0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: HMDB00224
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_ae0a472c_b617_437d_9cd7_337bc8680cbf
initial concentration: NaN
constant: false
is encoded by: hsa:2109
name: ETFB
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaR HPDCACRNt
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000269
name: heptadecanoate transport into the mitochondria
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
reversible: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_24b15753_9d9d_4a4e_a818_ecf084178ca7
is: Q3KQV9
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:91373
constant: false
has only substance units: false
initial concentration: NaN
name: UAP1L1
boundary condition: true

metaM 3mob m
constant: false
is: HMDB00019
is: CHEBI:11851
has only substance units: false
type: Species
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_944e9959_7ba4_480b_817b_b7094311f658
name: HSD17B4
initial amount: NaN
constant: false
is encoded by: hsa:3295
has only substance units: false
is: E9PB82
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaR FPGS2m
modifier: MODEL1310110059#
type: Reaction
name: folylpolyglutamate synthetase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.17
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
reversible: false
product: MODEL1310110059#
is: SBO:0000176

metaR CREATt4 2 r
fast: false
name: Creatine transport (sodium symport) (2:1)
type: Reaction
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_0fac921a_0e2d_4305_acc3_e5dcd24c7fb0
boundary condition: true
constant: false
name: LIPA
has only substance units: false
type: Species
is: P38571
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3988
initial concentration: NaN

metaM succoa c
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: HMDB01022
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: Succinyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110059#_e4b845d7_dbb7_414a_a10f_0b3f1f7d968b
type: Species
initial concentration: NaN
boundary condition: true
name: A4GALT
constant: false
is: SBO:0000252
is encoded by: hsa:53947
initial amount: NaN
has only substance units: false
is: Q9NPC4

metaR S6T6g
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
modifier: MODEL1310110059#

metaM arach c
is: HMDB02212
boundary condition: false
constant: false
name: arachidate
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:32360
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102

metaR S3TASE1ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110059#
fast: false

metaR TCYNTtm
reactant: MODEL1310110059#
type: Reaction
name: Thiocyanate transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
fast: false
kinetic law: MODEL1310110059#
reversible: false
is: SBO:0000185
product: MODEL1310110059#
is described by: ECO:0000000

metaR GALSIDEtl
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110059#
type: Reaction
name: galactocerebroside intracellular transport

metaM glu5sa c
boundary condition: false
name: L-Glutamate 5-semialdehyde
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: CHEBI:17232
is: C01165
has only substance units: false
is: SBO:0000247
is: HMDB02104
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

metaR HSAT4ly
type: Reaction
product: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is: SBO:0000185
reversible: false
reactant: MODEL1310110059#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110059#

metaR RE1135C
modifier: MODEL1310110059#
type: Reaction
name: RE1135
reversible: true
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
is version of: http://identifiers.org/ec-code/3.1.6.2
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110059#
product: MODEL1310110059#

metaR CSNAT3x
is version of: http://identifiers.org/ec-code/2.3.1.7
is described by: ECO:0000269
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000176
name: carnitine O-aceyltransferase, peroxisomal
reversible: true
type: Reaction
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ

metaR C180CRNt
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110059#
name: C180 transport into the mitochondria
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_946258b4_c48a_44e4_917c_935a454def09
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: ALDH1B1
is encoded by: hsa:219
initial concentration: NaN
type: Species
has only substance units: false
is: P30837

metaM 3thexddcoacrn c
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
is: HMDB02014
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C23H41NO5 CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_c2f2c9b4_f36a_45a2_aace_25251c025bf4
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:11001
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: O14975
name: SLC27A2

http://identifiers.org/biomodels.db/MODEL1310110059#_e4eb3098_155f_47b8_84fb_cbdecdf98148
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: Q9BXS1
is: SBO:0000252
boundary condition: true
name: IDI2
is encoded by: hsa:91734
initial concentration: NaN

metaM met L e
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: HMDB00696
is: SBO:0000247
name: L-methionine
initial concentration: 1.0
constant: false
is: CHEBI:16643

metaR r1384
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reversible: true
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
is: SBO:0000176

metaR CDSm
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.41
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
name: phosphatidate cytidylyltransferase

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM clpndcoa x
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205476
type: Species
has only substance units: false
is: C16166
constant: false
name: clupanodonyl CoA
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06267

http://identifiers.org/biomodels.db/MODEL1310110059#_f6cf5f78_08bd_4628_a436_4be4da290d8c
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:5152
name: PDE9A
initial amount: NaN

metaR P4508B13r
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
product: MODEL1310110059#
name: sterol 12-alpha-hydroxylase (nadh)
kinetic law: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.14.13.95
reversible: false

metaR r2043
modifier: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110059#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110059#
reversible: false
type: Reaction

metaR r0139
reversible: true
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110059#

metaR r0741
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110059#
reversible: true
fast: false
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_0719c9c2_13fd_431a_a8f7_451590137344
is: P52824
is encoded by: hsa:1609
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: DGKQ
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_60c7a342_7815_4cf4_b5f6_8488a1a1207f
has only substance units: false
is encoded by: hsa:1757
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is: A8K596
boundary condition: true
name: SARDH

http://identifiers.org/biomodels.db/MODEL1310110059#_b33b2ce8_1f79_4c98_84cf_d192abf98f0d
name: _U37519_1_e
has only substance units: false
boundary condition: true
is encoded by: hsa:U37519
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaR FAOXC225C226x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_044d4db8_ff7c_4753_940b_7d1e05ce6210
initial amount: NaN
constant: false
is encoded by: hsa:197258
name: FUK
is: Q8N0W3
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR SERTHRNaEx
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reversible: false

metaM xol7ah3 m
is: CHEBI:28540
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
has only substance units: false
initial amount: NaN
constant: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: HMDB12455
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_15d64fe8_628f_47b6_b160_2f3da78597ed
type: Species
is encoded by: hsa:25902
has only substance units: false
is: B2RD24
name: MTHFD1L
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR C10DCCACT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_0c9a1f7f_e495_44f2_9c42_1427875541db
initial concentration: NaN
boundary condition: true
type: Species
is: F6KD01
is: SBO:0000252
initial amount: NaN
constant: false
name: PTEN
has only substance units: false
is encoded by: hsa:5728

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaR CK
reactant: MODEL1310110059#
name: ATP Creatine kinase
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.3.2
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1159.1) or (1160.1) SUBSYSTEM: Urea cycle EC Number: 2.7.3.2 Confidence Level: 4 AUTHORS: PMID:1917943,PMID:2914937 NOTES:kegg C02305 MJC
product: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_dfe4a471_f9bb_46b1_afb4_9e07b7bfc514
type: Species
is: Q9UEF7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9365
boundary condition: true
constant: false
name: KL

metaM 4izp c
has only substance units: false
is: CHEBI:57255
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01014
name: 4-Imidazolone-5-propanoate

http://identifiers.org/biomodels.db/MODEL1310110059#_734b4db9_c0f7_429d_8740_38e139125c32
initial amount: NaN
name: SDHA:SDHB:SDHC:SDHD
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:6391
has part: P21912
is encoded by: hsa:6389
boundary condition: true
is encoded by: hsa:6390
is: SBO:0000297
has part: O14521
has part: P31040
is encoded by: hsa:6392
has part: Q99643
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_d890bd1f_5ade_49cf_a1bb_52a444a78e3b
is: SBO:0000297
is encoded by: hsa:476
has part: B7Z3U6
constant: false
is encoded by: hsa:483
boundary condition: true
has part: P54709
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
name: ATP1A1:ATP1B3

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaM apoC c
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:33190
type: Species
has only substance units: false
initial concentration: 1.0
name: Apocarboxlase (no lys residue)
is: HMDB11111

metaR r0027
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9

http://identifiers.org/biomodels.db/MODEL1310110059#_955f8362_d1bd_400b_a812_ad8f1005f1ed
is encoded by: hsa:158
has only substance units: false
type: Species
constant: false
boundary condition: true
name: ADSL
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR NDPK8n
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
fast: false
is described by: ECO:0000304
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_5992263a_6385_4a6b_a32f_bcd56f3d56da
initial amount: NaN
type: Species
is: SBO:0000252
name: CHST2
is encoded by: hsa:9435
initial concentration: NaN
constant: false
is: Q9Y4C5
has only substance units: false
boundary condition: true

metaM lnlncgcrn m
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06318
name: gamma-linolenyl carnitine
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR CERT1rt
type: Reaction
name: ceramide transport protein
is described by: ECO:0000304
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

http://identifiers.org/biomodels.db/MODEL1310110059#_78f2491c_3e3a_4044_a53b_d16775230738
name: SULT2A1
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: Q06520
is encoded by: hsa:6822
has only substance units: false
is: SBO:0000252

metaR ACGALtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reversible: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
name: N-acetyl-galactosamine lysosomal efflux
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110059#

metaM met L c
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:16643
is: HMDB00696
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
name: L-methionine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM btn m
initial concentration: 1.0
type: Species
is: HMDB00030
initial amount: NaN
constant: false
is: CHEBI:57586
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
name: biotinate
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR HSAT2ly
reactant: MODEL1310110059#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_8df652c0_bed3_4b07_9dcf_d5490c18f46b
type: Species
is encoded by: hsa:50
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ACO2
boundary condition: true
is: Q99798

metaM nrpphrsf e
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
type: Species
name: Sulfate derivative of norepinephrine
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/123747
is: HMDB02062
boundary condition: false

metaR RE3524R
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
name: RE3524

metaR CYTK2n
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
name: cytidylate kinase (dCMP),nuclear
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reactant: MODEL1310110059#

metaR CERT2gt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is described by: ECO:0000000
reversible: true
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
name: ceramide transport protein

http://identifiers.org/biomodels.db/MODEL1310110059#_46e19f16_fcd4_422f_8e68_fdca1a1988b8
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: O43315
name: AQP9
initial concentration: NaN
type: Species
is encoded by: hsa:366

metaM so4 m
boundary condition: false
is: HMDB01448
initial concentration: 1.0
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
is: CHEBI:16189
name: sulfate
initial amount: NaN
constant: false
is: SBO:0000247

metaM dopasf e
is: HMDB06275
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
initial concentration: 1.0
name: dopamine 3-O-sulfate
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:37946

metaM chol e
name: Choline
is: CHEBI:15354
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: C00114
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00097

metaM nadh m
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
type: Species
constant: false
is: CHEBI:57945
is: SBO:0000247
is: C00004
initial concentration: 1.0
is: HMDB01487

metaR PPItr
reversible: true
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Diphosphate transporter, endoplasmic reticulum

metaR FAOXC17C15m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaR r0743
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction

metaR ACACT10m
fast: false
is: SBO:0000176
modifier: MODEL1310110059#
reversible: true
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000134
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency

metaR SUCCOAPET
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR PYAM5POr
type: Reaction
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
product: MODEL1310110059#
name: pyridoxamine 5'-phosphate oxidase
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.4.3.5

metaM 3htdcoa c
initial amount: NaN
name: (S)-3-Hydroxytetradecanoyl-CoA
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
constant: false
boundary condition: false
is: HMDB02014
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaM CE4872 c
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial concentration: 1.0
has only substance units: false
is: HMDB00127
boundary condition: false
is: CHEBI:15748
type: Species
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_af81aef7_6d43_47fd_b259_748f0b9c3db4
type: Species
is: Q96CA6
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: ACAA1
is encoded by: hsa:30
has only substance units: false
initial concentration: NaN

metaR GALSIDEtg
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
name: galactocerebroside intracellular transport
is: SBO:0000185
reactant: MODEL1310110059#

metaM so4 l
is: CHEBI:16189
is: SBO:0000247
initial concentration: 1.0
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false

metaM etfrd m
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Electron transfer flavoprotein reduced
notes: FORMULA: RH2 CHARGE: 0
is: HMDB00145
is: CHEBI:17263
boundary condition: false
has only substance units: false
initial amount: NaN

metaR FATP7t
fast: false
name: fatty acid electroneutral transport
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaR r1381
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
is: SBO:0000176
reactant: MODEL1310110059#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_03886af2_a334_497c_8d9e_57bec01b1b45
is: SBO:0000252
name: HK1
has only substance units: false
type: Species
boundary condition: true
is: P19367
initial amount: NaN
constant: false
is encoded by: hsa:3098
initial concentration: NaN

metaR r0744
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110059#
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
product: MODEL1310110059#
type: Reaction
is: SBO:0000176

metaM gullac c
initial amount: NaN
is: HMDB03466
is: CHEBI:17587
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-gulono-1,4-lactone

http://identifiers.org/biomodels.db/MODEL1310110059#_f4d782b9_8694_4fd5_a23d_8d4c3b198039
name: ACADVL
is: SBO:0000252
is: P49748
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:37
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_dd926479_cdd3_4fb2_ac09_e217ba3049c8
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: OGDH
is encoded by: hsa:4967
is: Q02218
boundary condition: true
type: Species

metaR FAOXC12C12OHm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR SERDGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
is: SBO:0000185
name: D-Serine/Glycine reversible exchange
reversible: true
is described by: ECO:0000304

metaM cs b deg2 l
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: HMDB00812
type: Species
is: CHEBI:16953
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
initial concentration: 1.0
boundary condition: false

metaM dece3coa x
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
name: 3-decenoylcoa
is: SBO:0000247
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
boundary condition: false
has only substance units: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR r0022
modifier: MODEL1310110059#
fast: false
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110059#

metaM uacgam c
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
boundary condition: false
constant: false
is: CHEBI:57705
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

metaR FAOXC163C142x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_40c46705_db27_4453_91e8_c85c22aab047
is encoded by: hsa:5337
type: Species
constant: false
initial amount: NaN
is: Q59EA4
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PLD1
has only substance units: false

metaR r1829
name: Y+LAT2 Utilized transport
modifier: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110059#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1f23a4b7_ce43_4d6f_8e2a_1ba971801fc0
constant: false
has only substance units: false
boundary condition: true
name: ALDH6A1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q02252
type: Species
is encoded by: hsa:4329

metaM nrpphrsf c
is: HMDB02062
constant: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/123747
name: Sulfate derivative of norepinephrine
has only substance units: false
initial concentration: 1.0
type: Species

metaM ha e
is: CHEBI:16336
name: hyaluronan
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR GGH 5THFl
is described by: ECO:0000000
modifier: MODEL1310110059#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
product: MODEL1310110059#
reversible: false
name: Gamma-glutamyl hydrolase (5THF), lysosomal
kinetic law: MODEL1310110059#

metaR PMTCOAtx
name: fatty acid intracellular transport
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_eb57df0d_5c7a_446e_b837_265b4a1f7c0b
type: Species
name: ADCY1
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q08828
initial amount: NaN
is encoded by: hsa:107

metaR ELAIDCPT1
is described by: ECO:0000269
modifier: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase

metaR CYSALANaEx
is described by: ECO:0000269
fast: false
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
reversible: false
is: SBO:0000185
reactant: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR OAGD3tg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: oagd3 hs intracellular transport

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_659b40ee_c97e_45ef_8a18_8628e7e5d636
constant: false
name: MTMR3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8897
type: Species
boundary condition: true
initial amount: NaN
is: Q13615
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_1e92628e_eb33_416d_adc7_7fcbd61d106f
name: _NM_013421_1_e
type: Species
initial concentration: NaN
is encoded by: hsa:NM 013421
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaR BACCLm
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
type: Reaction
is: SBO:0000176
modifier: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110059#_9f759d99_9a79_40be_a698_8667bd97c310
is: F5GWS5
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55811
initial amount: NaN
boundary condition: true
name: ADCY10
type: Species
is: SBO:0000252
constant: false

metaR BHMT
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (23743.1) or (635.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.5 Confidence Level: 4 AUTHORS: PMID:9281325 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.1.1.5
name: betaine-homocysteine S-methyltransferase

metaM hexdicoa r
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB00672
is: SBO:0000247
initial amount: NaN
name: hexadecanedioylcoa
is: C08260
notes: FORMULA: C37H59N7O19P3S CHARGE: -5

metaM leuktrD4 e
is: CHEBI:28666
has only substance units: false
name: Leukotriene D4
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB03080
boundary condition: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
type: Species
initial concentration: 1.0

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_26406553_3c38_4fa8_b85f_7efae0eeb49f
constant: false
initial amount: NaN
type: Species
name: SLC26A7
boundary condition: true
is encoded by: hsa:115111
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_dd20d5db_5a2d_4bd0_b212_eecd9de56b3d
is: SBO:0000252
is encoded by: hsa:80308
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: Q8NFF5
initial concentration: NaN
boundary condition: true
name: FLAD1

http://identifiers.org/biomodels.db/MODEL1310110059#_3c7585e6_f148_4187_8331_328332c1bf7f
name: LDHA
is encoded by: hsa:3939
is: P00338
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR ELAIDCPT2
reactant: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
product: MODEL1310110059#
type: Reaction
name: carnitine transferase

metaM sebacid x
has only substance units: false
initial concentration: 1.0
name: sebacicacid
constant: false
is: SBO:0000247
notes: FORMULA: C10H16O4 CHARGE: -2
initial amount: NaN
type: Species
is: HMDB00792
boundary condition: false
is: C08277

metaR GALSGLT1le
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_9561f78c_2576_4cbc_a245_8ea3a323840a
initial amount: NaN
name: GALT
is: B4E097
is encoded by: hsa:2592
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_87fcf7d1_525b_4a83_9da4_42cdfc39c060
boundary condition: true
constant: false
name: CHKA
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:1119
initial amount: NaN

metaM lnlc c
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: HMDB00673
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: linoleate
is: CHEBI:30245
initial concentration: 1.0
constant: false
initial amount: NaN

metaR HEDCECRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaR S23T2g
reversible: false
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
product: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_53d6dd22_9aa3_42dc_b7a0_1da35bfdc1f0
is: G3V5N0
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: FUT8
constant: false
is encoded by: hsa:2530

metaR r0747
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110059#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
modifier: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_709c53c6_b308_4171_b46e_5a2231f8ab32
name: NDUFV1
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: E5KNH5
is encoded by: hsa:4723

metaM 5tedtricoa x
has only substance units: false
constant: false
boundary condition: false
is: HMDB02288
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 5,8,11-tetradecatrienoylcoa
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4

metaM 1p3h5c c
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:6151
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
type: Species
constant: false

metaM 7thf e
type: Species
has only substance units: false
constant: false
boundary condition: false
name: heptaglutamyl folate (THF)
notes: FORMULA: C49H57N13O24 CHARGE: -8
initial amount: NaN
is: SBO:0000247
is: HMDB06559
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_0a8b9515_66bc_41db_8916_8706148b4dc3
type: Species
is: Q9UMR5
is encoded by: hsa:9374
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PPT2
boundary condition: true
constant: false
has only substance units: false

metaR PSFLIPm
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
reactant: MODEL1310110059#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.1
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
name: phosphatidylserine flippase

metaR r1827
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_367343c2_2798_4712_aea0_7ef6d92f05bd
name: _AL050025_1_c
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AL050025
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaR TDCHOLAtx
product: MODEL1310110059#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#
name: bile acid intracellular transport
reversible: true
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185

metaM HC01672 c
type: Species
boundary condition: false
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:37666
name: Acetyl adenylate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_24a43867_0d90_4d9e_a97e_513aa4d39add
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: B3GALT5
initial concentration: NaN
boundary condition: true
is: Q9Y2C3
is encoded by: hsa:10317
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ce7aaef1_ae17_419a_9ab4_502322e6401b
initial amount: NaN
boundary condition: true
is encoded by: hsa:38
is: SBO:0000252
constant: false
has only substance units: false
is: P24752
initial concentration: NaN
type: Species
name: ACAT1

metaM 5thf m
type: Species
name: pentaglutamyl folate (THF)
is: CHEBI:3729
is: C00440
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01396
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110059#_b1eb9583_4a8a_4b2d_914e_950f505bf8a0
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:5152
initial concentration: NaN
name: PDE9A
is: SBO:0000252
initial amount: NaN

metaM leuktrD4 c
type: Species
name: Leukotriene D4
is: CHEBI:28666
initial amount: NaN
is: SBO:0000247
is: HMDB03080
boundary condition: false
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
has only substance units: false

metaR SMPD3g
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000176
reversible: false
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
fast: false
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.4.12
kinetic law: MODEL1310110059#
is described by: ECO:0000304

metaM ksii core2 deg5 l
is: CHEBI:12936
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: HMDB00143
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 5
type: Species
initial concentration: 1.0
notes: FORMULA: C50H82N4O38SX CHARGE: -1

metaR COQ5m
is described by: ECO:0000000
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
kinetic law: MODEL1310110059#
type: Reaction
name: Ubiquinone biosynthesis methyltransferase COQ5
reversible: false
is: SBO:0000176
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_111d2c00_fed8_409a_bf35_11c3195a07e8
is encoded by: hsa:175
name: AGA
is: P20933
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_4ea03246_13a2_4e20_9096_0b97e4a68a62
boundary condition: true
initial concentration: NaN
name: PDE4C
is encoded by: hsa:5143
has only substance units: false
initial amount: NaN
is: Q7KYS4
constant: false
type: Species
is: SBO:0000252

metaR PPItm
reversible: true
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
type: Reaction
kinetic law: MODEL1310110059#
name: diphopshate transporter, mitochondrial

metaR CAt7r
modifier: MODEL1310110059#
fast: false
type: Reaction
name: calcium / sodium antiporter (1:3), reversible
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
is described by: ECO:0000269
reversible: true

metaM uacgam g
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false
is: CHEBI:57705
type: Species
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
is: SBO:0000247

metaM gumgchol e
is: HMDB00626
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C2760026H5060043NO2530006 CHARGE: 0
name: guar gum-glycocholate complex
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM Sfglutth c
initial concentration: 1.0
is: SBO:0000247
is: HMDB01550
type: Species
boundary condition: false
constant: false
name: S-formylglutathionate(1-)
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN
is: CHEBI:57688
has only substance units: false

metaM nadh c
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: HMDB01487
boundary condition: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
is: CHEBI:57945
initial concentration: 1.0
is: C00004

metaR GGH 6DHFe
reversible: false
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110059#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000000

metaM ksii core4 pre4 g
notes: FORMULA: C61H99N5O43X CHARGE: -1
initial amount: NaN
constant: false
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 4
is: C00130
is: SBO:0000247
has only substance units: false
is: HMDB00175
initial concentration: 1.0
type: Species
boundary condition: false

metaR CRNtim
reversible: false
is: SBO:0000185
type: Reaction
fast: false
name: L-carnitine transport out of mitochondria via diffusion
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110059#

metaM cs a deg5 l
is: SBO:0000247
type: Species
notes: FORMULA: C23H36O24S CHARGE: -2
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15936
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_eb49cbe5_dd06_4cd5_bf27_4491da82fb98
is: Q86YW0
initial amount: NaN
constant: false
name: PLCZ1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:89869
boundary condition: true

metaM 5thf l
is: SBO:0000247
name: pentaglutamyl folate (THF)
is: C00440
initial amount: NaN
is: HMDB01396
constant: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
boundary condition: false
is: CHEBI:3729
initial concentration: 1.0
has only substance units: false
type: Species

metaR NTD1
reversible: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110059#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
kinetic law: MODEL1310110059#
name: 5'-nucleotidase (dUMP)

metaR TRPt
is described by: ECO:0000269
fast: false
name: L-tryptophan transport
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reactant: MODEL1310110059#

metaM dudp c
is: C01346
is: CHEBI:60471
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: dUDP
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_38528196_1c74_41c4_be89_42d872ad6d30
type: Species
initial amount: NaN
has only substance units: false
name: _R06874_1_r
is encoded by: hsa:R06874
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM apoC Lys btn m
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
has only substance units: false
initial amount: NaN
is: HMDB03134
type: Species
initial concentration: 1.0
is: C05552
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false
is: SBO:0000247

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_fff931d1_79ae_497e_a03a_5217659f3ac5
is encoded by: hsa:10588
name: MTHFS
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: P49914
type: Species
is: SBO:0000252
initial concentration: NaN

metaM btn e
is: C00120
name: Biotin
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB00030
initial amount: NaN
is: CHEBI:3420
is: SBO:0000247

metaR RE1518M
product: MODEL1310110059#
name: RE1518
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is: SBO:0000176
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
reversible: true
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_979f8e37_07de_489b_99f4_e2899c27d4e8
constant: false
boundary condition: true
name: PLCD4
is: SBO:0000252
is: Q9BRC7
has only substance units: false
is encoded by: hsa:84812
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_2b8f19eb_0109_40ee_95b6_c67e006272f7
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:134526
boundary condition: true
is: Q5FWE9
name: ACOT12
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM dhlam m
constant: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
type: Species
name: dihydrolipoamide
is: HMDB00985
has only substance units: false
is: CHEBI:17694
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM biocyt m
initial amount: NaN
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species

metaM succoa x
initial amount: NaN
constant: false
name: Succinyl-CoA
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01022
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
type: Species
has only substance units: false

metaM 2hb e
constant: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
is: SBO:0000247
name: 2-Hydroxybutyrate
is: HMDB00008
boundary condition: false
is: CHEBI:1148

http://identifiers.org/biomodels.db/MODEL1310110059#_01379343_4450_4650_97ab_f1eb8eb58540
initial concentration: NaN
constant: false
is: Q92820
initial amount: NaN
is encoded by: hsa:8836
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GGH
type: Species

metaR CYTK12n
kinetic law: MODEL1310110059#
name: cytidylate kinase (dCMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR AG13T16g
is: SBO:0000176
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110059#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction

metaM tetpent6 c
name: tetracosapentaenoic acid, n-6
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: HMDB06322
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_934af1b2_6373_4259_9fe3_581c4b0e77e6
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: FTMT
initial concentration: NaN
is: Q8N4E7
boundary condition: true
is encoded by: hsa:94033

metaR 4HGLSDm
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial

metaM hs deg13 l
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial concentration: 1.0
is: SBO:0000247
name: heparan sulfate, degradation product 13
is: HMDB06210
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM sgalside hs c
boundary condition: false
is: HMDB03406
name: sulfatide galactocerebroside
initial amount: NaN
constant: false
is: CHEBI:16523
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1

metaR LEUGLYHYc
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
name: hydrolysis of leucylglycine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110059#
fast: false
type: Reaction

metaM trdrd c
is: SBO:0000247
is: CHEBI:15967
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
is: C00342

http://identifiers.org/biomodels.db/MODEL1310110059#_fda4404a_2d50_4ca4_ae60_53f0b62e6fb2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI818585
name: _AI818585_1_c
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false

metaR ADK3m
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.10
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
name: adentylate kinase (GTP)
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
product: MODEL1310110059#
reversible: true

metaR HPDCACRNCPT1
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
modifier: MODEL1310110059#
name: carnitine fatty-acyl transferase
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is: SBO:0000176

metaR NTD3
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000269
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110059#
reversible: false
name: 5'-nucleotidase (dCMP)

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a1aab823_37a6_4c13_8182_71fa37652fdc
is encoded by: hsa:2181
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: ACSL3
boundary condition: true
is: B3KMA6
is: SBO:0000252

metaR IVCOAACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaM HC01712 m
constant: false
is: SBO:0000247
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
type: Species
name: S-Glutaryldihydrolipoamide
has only substance units: false
boundary condition: false
is: CHEBI:28391
initial concentration: 1.0
initial amount: NaN

metaR FAOXC226C227m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR C10OHc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaM 3dpdhb m
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+
is: CHEBI:50775
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM q10 c
is: SBO:0000247
name: ubiquinone-10
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01072
initial concentration: 1.0
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: CHEBI:46245
constant: false
boundary condition: false

metaM 2hb c
is: CHEBI:1148
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
name: 2-Hydroxybutyrate
type: Species
is: HMDB00008

metaR HMBS
type: Reaction
is described by: ECO:0000254
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.61
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
fast: false
name: hydroxymethylbilane synthase
is: SBO:0000176

metaM tetpent6 e
name: tetracosapentaenoic acid, n-6
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB06322
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_5d78ad3e_e0c0_4317_b5cc_869e7a66dc77
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4731
is: SBO:0000297
is encoded by: hsa:4712
constant: false
has only substance units: false
boundary condition: true
has part: Q5VYT2
type: Species
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3

metaM apoC m
name: Apocarboxlase (no lys residue)
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00182
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:32551
notes: FORMULA: XH CHARGE: 0

metaM glc D r
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
is: HMDB00122
initial concentration: 1.0
boundary condition: false
constant: false
name: D-glucose
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:4167

metaR GLNCYSNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110059#
is described by: ECO:0000269
kinetic law: MODEL1310110059#
is: SBO:0000185
reactant: MODEL1310110059#
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
fast: false
reversible: false
modifier: MODEL1310110059#
type: Reaction

metaR OAGD3te
type: Reaction
is: SBO:0000185
reactant: MODEL1310110059#
name: oagd3 hs transport
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_4f0ad945_ef43_414a_a0b7_de7b1aaa8a8b
has only substance units: false
is encoded by: hsa:5538
name: PPT1
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: Q6FGQ4
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_8e63dc75_c761_4558_bb84_13289be4d6df
boundary condition: true
initial amount: NaN
name: SLC2A8
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:29988
is: Q9NY64
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_67b9fd05_6f4d_4364_a4c1_ffda30d28a09
name: NME7
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:29922
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_a87ed4e1_67b6_4e9d_a3ad_667fbcbf4fc2
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: Q9UHW9
is encoded by: hsa:9990
initial concentration: NaN
name: SLC12A6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_7c2c7e7e_b5e5_4f3f_b623_156838c5d6cb
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:55229
has only substance units: false
is: Q9NVE7
initial concentration: NaN
name: PANK4
initial amount: NaN

metaM chol c
is: C00114
is: HMDB00097
has only substance units: false
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Choline

http://identifiers.org/biomodels.db/MODEL1310110059#_27413357_7017_4ef1_b588_6b6b3456a86b
initial amount: NaN
is: A8K7J7
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:3098
name: HK1
boundary condition: true

metaR RE3001M
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.34
is described by: ECO:0000000
product: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
name: RE3001
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110059#
is: SBO:0000176

metaR NTD5
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110059#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
product: MODEL1310110059#
name: 5'-nucleotidase (dTMP)
reversible: false
kinetic law: MODEL1310110059#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR GGH 10FTHF5GLUe
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110059#
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_e6ac22de_ed6f_4b66_9d1b_ea53164bfb60
constant: false
initial concentration: NaN
has only substance units: false
is: Q9H1K4
boundary condition: true
is encoded by: hsa:83733
initial amount: NaN
type: Species
name: SLC25A18
is: SBO:0000252

metaR FAOXC225C204m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR r1380
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
is: SBO:0000176
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_38d1aa90_dac0_47a0_9520_44e506661354
is encoded by: hsa:765
name: CA6
is: Q5FC00
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM 1p3h5c m
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
boundary condition: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: CHEBI:6151
is: HMDB01369
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false

metaR S6TASE20ly
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110059#
fast: false
type: Reaction

metaR DOLP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110059#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110059#
reversible: false
name: dolichol phosphate flippase (liver)

metaM ha l
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
name: hyaluronan
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16336

metaR GLYt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
is described by: ECO:0000304
fast: false
name: glycine reversible transport via proton symport
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
reversible: true

metaR PPCOACm
reversible: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
is version of: http://identifiers.org/ec-code/6.4.1.3
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176
name: Propionyl-CoA carboxylase, mitochondrial
modifier: MODEL1310110059#
product: MODEL1310110059#

metaM ppcoa c
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
constant: false
is: CHEBI:57392
is: HMDB01275
is: SBO:0000247
is: C00100
initial amount: NaN
type: Species
initial concentration: 1.0
name: Propanoyl-CoA
boundary condition: false

metaM 2mop c
type: Species
constant: false
is: HMDB01172
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_dca2302f_c784_4bb1_b34e_330330f26f8e
name: ALDH5A1
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:7915
initial concentration: NaN
is: Q546H9
has only substance units: false
initial amount: NaN

metaM q10 e
constant: false
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: ubiquinone-10
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01072

http://identifiers.org/biomodels.db/MODEL1310110059#_fa84afab_8d9e_4cc9_be87_cdfe2c1aaf6f
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: Q8TBF5
is: SBO:0000252
is encoded by: hsa:54965
boundary condition: true
name: PIGX

metaR FBP26
fast: false
name: Fructose-2,6-bisphosphate 2-phosphatase
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
is version of: http://identifiers.org/ec-code/2.7.1.105
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.11

metaR DMGtm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
fast: false
name: dimethylglycine transport via diffusion (cytosol to mitochondria)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reversible: true
reactant: MODEL1310110059#
type: Reaction

metaM Rtotal2 e
initial amount: NaN
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
constant: false
is: SBO:0000247
is: HMDB00244
is: C00255
has only substance units: false
type: Species
name: R total 2 position
is: CHEBI:3554
initial concentration: 1.0

metaM dopasf c
is: HMDB06275
name: dopamine 3-O-sulfate
boundary condition: false
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
initial amount: NaN
is: CHEBI:37946
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_c16f04af_e710_478f_bcc8_9fc0b5dfca83
type: Species
name: ALDH2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:217
has only substance units: false
constant: false
is: P05091
boundary condition: true
is: SBO:0000252

metaR r2330
kinetic law: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
fast: false
reversible: true
reactant: MODEL1310110059#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaM pect e
name: pectins
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C2535H3509O2535 CHARGE: -1
is: HMDB03402
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_58c8f126_f528_4f57_ae24_346d00195b16
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AA854479
has only substance units: false
name: _AA854479_1_m
is: SBO:0000252
initial concentration: NaN

metaR HPDCACRNCPT2
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176
fast: false
name: heptadecanoate transport into the mitochondria
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110059#_87eaeeb0_1472_4115_be46_e4bfe47917c8
initial amount: NaN
is: SBO:0000252
type: Species
name: PIK3R5
boundary condition: true
has only substance units: false
is: Q8WYR1
is encoded by: hsa:23533
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_54e0b12a_82e8_4f48_aa4b_055a75e57f2d
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6547
is: SBO:0000252
name: SLC8A3
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_df7fda00_9b43_481b_b709_0fb792642fb8
is encoded by: hsa:2582
initial amount: NaN
boundary condition: true
has only substance units: false
name: GALE
initial concentration: NaN
is: Q38G75
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_91ab3893_cd40_4ae1_a9b0_5d9df6649ce0
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:AA081045
is: SBO:0000252
initial amount: NaN
name: _AA081045_1_e

metaR NTD8
name: 5'-nucleotidase (dGMP)
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110059#
type: Reaction

metaR r0892
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
modifier: MODEL1310110059#
fast: false
is described by: ECO:0000000
name: Facilitated diffusion
reversible: true
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.2.27
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_27dd94bf_a5f9_4044_b2f7_894c3ec1f3a4
initial amount: NaN
name: UPP2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: O95045
is encoded by: hsa:151531
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_9578c01b_a972_43aa_b62f_cfdae00aa773
boundary condition: true
initial amount: NaN
name: UPP1
constant: false
has only substance units: false
is encoded by: hsa:7378
initial concentration: NaN
type: Species
is: SBO:0000252

metaR LEULEULAPc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaM dd3coa x
constant: false
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: 3-dodecenoylcoa
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB04257

MODEL1310110059
species: metaM sprm e
reaction: metaR r2358
species: metaM hs deg15 l
reaction: metaR ARACHDt2
reaction: metaR DHAPtc
reaction: metaR RTOTAL2FATPc
reaction: metaR FACOAL140i
reaction: metaR URIt
species: metaM dcdp n
species: metaM tsul e
reaction: metaR LNLNCACPT2
species: metaM ksii core4 pre1 g
species: metaM prgstrn c
reaction: metaR r1829
reaction: metaR PGDI
species: metaM HC00695 m
species: metaM glyc3p c
species: metaM CE2839 e
reaction: metaR r0931
species: metaM 3hodcoa c
species: metaM ksii core2 pre8 g
species: metaM ksi deg4 l
reaction: metaR H2Otg
reaction: metaR HIVCRNe
reaction: metaR C162OHc
reaction: metaR r1913
species: metaM c10dc c
reaction: metaR THRSERNaEx
reaction: metaR DAGKn hs
reaction: metaR ELAIDCRNt
species: metaM c6dc x
reaction: metaR r0594
reaction: metaR CREATt4 2 r
reaction: metaR TETPENT3t
reaction: metaR r1615
species: metaM ksi deg7 l
reaction: metaR 4NPHSULT
reaction: metaR r0139
reaction: metaR ACOAD9m
reaction: metaR GLUt2m
species: metaM ppp9 m
reaction: metaR r1050
species: metaM CE5126 x
species: metaM Sfglutth c
reaction: metaR BACCLm
reaction: metaR EX taur LPAREN e RPAREN
reaction: metaR ALA DASH DTDe
species: metaM ac m
species: metaM dlnlcgcoa c
reaction: metaR LALDO
species: metaM ksi pre2 g
reaction: metaR PPBNGS
reaction: metaR NTD1
reaction: metaR GMPR
species: metaM amp c
species: metaM c10crn e
reaction: metaR PPItm
species: metaM so4 l
reaction: metaR r1721
reaction: metaR ACNACNGALGBSIDEte
reaction: metaR G13MT L
reaction: metaR RE2814R
reaction: metaR COQ6m
reaction: metaR ACONT
species: metaM tdchola e
species: metaM bilirub e
reaction: metaR G5SDym
species: metaM dgsn e
species: metaM tststerone c
reaction: metaR LYStm
reaction: metaR H2O2tn
reaction: metaR GALASE9ly
reaction: metaR CYTK2
species: metaM tyr L e
species: metaM pchol hs m
reaction: metaR S3TASE1ly
species: metaM pi l
reaction: metaR EX retn LPAREN e RPAREN
species: metaM dlnlcgcrn c
reaction: metaR GALASE19ly

metaR GLYCTO1p
reversible: false
name: Glycolate oxidase, peroxisome
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
reactant: MODEL1310110059#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.3.15
product: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_b2138827_604b_45d0_b12b_d951ea8f1ad9
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC17A8
boundary condition: true
is encoded by: hsa:246213
constant: false
initial amount: NaN
is: Q8NDX2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_adcf1949_cfdd_4fca_ac7d_50b881e986ec
initial amount: NaN
type: Species
has only substance units: false
is: Q9HCR9
is encoded by: hsa:50940
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: PDE11A

http://identifiers.org/biomodels.db/MODEL1310110059#_b48bcfcd_992b_4d05_9d9e_f5965344e844
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC27A4
is: Q6P1M0
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10999

metaR UDPGALtg
modifier: MODEL1310110059#
type: Reaction
reversible: true
reactant: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
name: UDP-Gal Golgi transport via CMP antiport
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD

metaR r2331
product: MODEL1310110059#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_1e00b1c6_1fe2_4924_bb3c_04cf3c0ecbf5
is encoded by: hsa:22934
type: Species
is: P49247
boundary condition: true
is: SBO:0000252
name: RPIA
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR RE2759X
reversible: true
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
modifier: MODEL1310110059#
is: SBO:0000176
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/5.1.99.4
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
name: RE2759

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM 5thf e
has only substance units: false
constant: false
is: HMDB06487
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: SBO:0000247
initial concentration: 1.0
type: Species
name: pentaglutamyl folate (THF)
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_4f148ddd_6564_4678_a626_9cb4b13ca41a
type: Species
constant: false
name: GUCY1B3
initial concentration: NaN
is encoded by: hsa:2983
is: Q02153
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR GLYSNAT5tc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a31e0ff0_200e_4a16_8302_d5c41564e36b
type: Species
name: PMM1
initial concentration: NaN
is encoded by: hsa:5372
initial amount: NaN
is: A8K003
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaM Rtotal2 c
is: CHEBI:57876
type: Species
initial amount: NaN
is: HMDB01564
name: R total 2 position
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false

metaR r2332
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR PPAn
name: inorganic diphosphatase, nuclear
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
is described by: ECO:0000000
product: MODEL1310110059#

metaR OCD11CRNCACT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM ksi deg3 l
name: keratan sulfate I, degradation product 3
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00573
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: SBO:0000247
is: CHEBI:30825

metaR r2312
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110059#

metaR CYSO
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110059#
type: Reaction
name: cysteine oxidase
product: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.20
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT

metaR r0308
is described by: ECO:0000000
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
product: MODEL1310110059#
type: Reaction

metaM dttp n
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: C00459
boundary condition: false
is: HMDB01342
name: dTTP
constant: false
is: CHEBI:37568
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_28e4e69d_be48_4674_9e01_debbb9b20421
name: ASPA
is: SBO:0000252
is: Q6FH48
has only substance units: false
is encoded by: hsa:443
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaR 3MOBte
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
product: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxobutanoate
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR FAOXC226
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#

metaM tettet6coa x
initial concentration: 1.0
is: C16171
is: http://identifiers.org/pubchem.compound/47205481
initial amount: NaN
boundary condition: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
type: Species
is: SBO:0000247
name: tetracosatetraenoyl coenzyme A
is: HMDB06516
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_0ef2d1b6_1283_4c4c_81d4_aef6061622d1
type: Species
name: NDUFB4
constant: false
is: O95168
is encoded by: hsa:4710
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_df021804_61f8_4ff1_85b1_3a6ee5bdd467
boundary condition: true
initial amount: NaN
name: ENTPD8
is encoded by: hsa:377841
is: SBO:0000252
type: Species
has only substance units: false
is: Q5MY95
constant: false
initial concentration: NaN

metaR FRDPtr
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
product: MODEL1310110059#
name: lipid, flip-flop intracellular transport
fast: false
is described by: ECO:0000000

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_f5e87714_89a5_4d50_9148_e72386fb4cca
is encoded by: hsa:197257
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: LDHD
has only substance units: false

metaM ksi pre26 g
type: Species
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 26
boundary condition: false
has only substance units: false
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_0e386652_b19a_4f07_bf07_19130a112718
initial concentration: NaN
constant: false
is encoded by: hsa:314
has only substance units: false
type: Species
name: AOC2
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r2311
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110059#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000000

metaM Asn X Ser Thr l
initial amount: NaN
has only substance units: false
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
constant: false
is: HMDB00051
type: Species
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: C01342
is: CHEBI:28938

metaR GGH 6DHFl
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110059#
name: Gamma-glutamyl hydrolase (6DHF), lysosomal
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_89daf85f_c1d3_416f_8860_44f2d66bd0bd
boundary condition: true
is encoded by: hsa:1356
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: CP
type: Species
is: P00450
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_72f71557_079b_4c9f_a97d_c536d4e7375b
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC4A5
initial amount: NaN
boundary condition: true
is encoded by: hsa:57835
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ea99b917_8670_4acb_9541_4997ed71ecd7
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: HAS1
is: Q8IYH3
is encoded by: hsa:3036

metaM pap g
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
is: CHEBI:58343
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: HMDB00061
is: SBO:0000247
boundary condition: false

metaM ribflv e
is: HMDB00244
constant: false
initial concentration: 1.0
is: C00255
name: Riboflavin
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:3554
has only substance units: false

metaM 3mop e
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: CHEBI:28654
type: Species
initial concentration: 1.0
name: 3-methyl-2-oxopentanoate
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00491

http://identifiers.org/biomodels.db/MODEL1310110059#_a2d746b1_16c2_419c_be18_455ec7a15f30
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: P04062
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2629
name: GBA

http://identifiers.org/biomodels.db/MODEL1310110059#_818eb016_9bd3_4b7c_bd9a_d8b58ab09df5
boundary condition: true
constant: false
name: CA2
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:760
is: P00918
has only substance units: false
is: SBO:0000252

metaR ACACt2
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000269
name: acetoacetate transport via proton symport
product: MODEL1310110059#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reactant: MODEL1310110059#

metaR PItx
reversible: true
name: Phosphate transporter, peroxisome
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction

metaM ksii core4 pre6 g
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C69H111N6O51SX CHARGE: -2
is: CHEBI:28067
is: SBO:0000247
type: Species

metaR r2310
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000

metaR r0451
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110059#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
fast: false
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_616893f5_f9ae_4cda_aa92_4ae68373cf84
is: SBO:0000252
type: Species
is encoded by: hsa:3417
initial concentration: NaN
name: IDH1
is: O75874
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaR KAS8
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
product: MODEL1310110059#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
type: Reaction
name: b-ketoacyl synthetase (palmitate, n-C16:0)
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaM amp x
is: C00020
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: AMP
initial amount: NaN
is: SBO:0000247
is: CHEBI:456215
is: HMDB00045
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaM ppcoa x
constant: false
initial concentration: 1.0
is: C00100
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
boundary condition: false
is: CHEBI:57392

http://identifiers.org/biomodels.db/MODEL1310110059#_9e0b7962_1cc0_41c0_bec6_bc94189800ef
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:517
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: Q06055
name: ATP5G2

http://identifiers.org/biomodels.db/MODEL1310110059#_620d4a7a_022d_4417_ae73_f1f827009863
initial amount: NaN
has only substance units: false
type: Species
name: ACADM
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:34
boundary condition: true
is: P11310
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_3671efaa_6288_467d_9830_dab152bab214
name: LDHAL6A
constant: false
is encoded by: hsa:160287
boundary condition: true
initial amount: NaN
is: Q6ZMR3
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR PGDI
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.99.2
fast: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is described by: ECO:0000269
name: Prostaglandin-H2 D-isomerase [Precursor]
is version of: http://identifiers.org/ec-code/2.5.1.18
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
product: MODEL1310110059#
is: SBO:0000176

metaR PPAm
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
name: inorganic diphosphatase
is described by: ECO:0000269
fast: false

metaM apoC Lys btn c
is: SBO:0000247
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00182
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:32551
notes: FORMULA: C16H27N4O3SX CHARGE: 0

metaR FAOXC101C102x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_fde47e2f_df7e_4054_bac3_3f8c75defdfe
initial concentration: NaN
is encoded by: hsa:766
initial amount: NaN
is: P43166
name: CA7
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_6bdbbc80_71cd_46fd_9335_32ae25f81d1a
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: P30838
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ALDH3A1
is encoded by: hsa:218

metaM 7dhf e
has only substance units: false
boundary condition: false
is: HMDB06559
initial amount: NaN
is: SBO:0000247
type: Species
name: heptaglutamyl folate (DHF)
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false

metaM sebacid c
boundary condition: false
is: C08277
notes: FORMULA: C10H16O4 CHARGE: -2
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00792
type: Species
name: sebacicacid

http://identifiers.org/biomodels.db/MODEL1310110059#_2c4d45d5_3db4_4bd9_9d9c_5a27564ded47
initial amount: NaN
name: SLC8A1
constant: false
has only substance units: false
is encoded by: hsa:6546
type: Species
initial concentration: NaN
is: F6VPY9
is: SBO:0000252
boundary condition: true

metaR LGNCCOAtx
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
type: Reaction
name: fatty acid intracellular transport
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#

metaM etoh e
is: HMDB00108
name: ethanol
initial amount: NaN
is: CHEBI:16236
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_eb53a8af_a83c_4a57_8ff6_333a86adacd6
has only substance units: false
constant: false
name: GALNT6
boundary condition: true
initial amount: NaN
is: Q8NCL4
initial concentration: NaN
is encoded by: hsa:11226
type: Species
is: SBO:0000252

metaM dtmp e
boundary condition: false
constant: false
type: Species
name: dTMP(2-)
is: HMDB01227
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:26999
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: SBO:0000247

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR r0450
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
modifier: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
reversible: true
type: Reaction

metaM ditp c
type: Species
name: dITP(4-)
is: CHEBI:61382
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB03537
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247

metaM ribflv c
initial concentration: 1.0
name: Riboflavin
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: HMDB00244
constant: false
is: C00255
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:3554

http://identifiers.org/biomodels.db/MODEL1310110059#_9b6e0d73_7818_495d_9821_cc8078982c66
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3421
initial concentration: NaN
type: Species
has part: P51553
constant: false
is: SBO:0000297
has part: O43837
is encoded by: hsa:3420
name: IDH3A:IDH3B:IDH3G

metaM 3mop c
constant: false
initial concentration: 1.0
name: 3-methyl-2-oxopentanoate
has only substance units: false
initial amount: NaN
is: HMDB00491
is: CHEBI:28654
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: SBO:0000247
boundary condition: false

metaR ADPACDAc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR r2316
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_57ccaf61_7c17_4c82_b8d1_8b9e95747f4c
name: GALNT9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:50614
has only substance units: false
constant: false
is: Q9HCQ5
boundary condition: true
initial concentration: NaN
type: Species

metaM arachd x
boundary condition: false
is: CHEBI:32395
is: SBO:0000247
name: arachidonate
constant: false
initial concentration: 1.0
type: Species
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_c15b61b5_124b_4f3c_8f3e_86ad051793e7
constant: false
initial concentration: NaN
is: Q1ET61
is encoded by: hsa:6818
name: SULT1A3
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR GTHO
is described by: ECO:0000254
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110059#
fast: false
type: Reaction
product: MODEL1310110059#
name: glutathione oxidoreductase
reactant: MODEL1310110059#

metaM ppp9 m
boundary condition: false
is: CHEBI:36159
type: Species
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
initial amount: NaN
is: SBO:0000247
constant: false
name: Protoporphyrin
initial concentration: 1.0
has only substance units: false
is: HMDB00241

metaM etoh c
name: ethanol
constant: false
initial concentration: 1.0
is: HMDB00108
is: CHEBI:16236
initial amount: NaN
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_79706415_9b71_45ee_aa00_76abe149b49f
is: O43820
has only substance units: false
initial amount: NaN
name: HYAL3
type: Species
is encoded by: hsa:8372
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r2315
product: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110059#

metaM HC01118 r
name: presqualene diphosphate(3-)
type: Species
is: CHEBI:57310
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM 3octdece1crn c
notes: FORMULA: C25H47NO5 CHARGE: 0
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB13336
name: 3-hydroxy-octadecenoyl carnitine
type: Species
constant: false

metaM hspg l
is: HMDB01993
boundary condition: false
name: heparan sulfate proteoglycan
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:17899
initial concentration: 1.0
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_073c84fc_56a8_4a47_96fd_776ffd7ba2eb
boundary condition: true
initial concentration: NaN
name: LDHC
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:3948
constant: false

metaM hexdicoa c
name: hexadecanedioylcoa
is: HMDB02014
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR C102CPT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR G14T9g
is: SBO:0000176
reactant: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110059#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR GTHP
reactant: MODEL1310110059#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.15
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.12
kinetic law: MODEL1310110059#
fast: false
reversible: true
modifier: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.11.1.9
type: Reaction
name: glutathione peroxidase

http://identifiers.org/biomodels.db/MODEL1310110059#_eca4c8f2_9a12_4fbe_acc2_3e890a21dee2
name: PAICS
type: Species
constant: false
is: P22234
initial amount: NaN
is encoded by: hsa:10606
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM hs deg21 l
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:16126
boundary condition: false
constant: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: SBO:0000247
initial amount: NaN
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose

metaR r2314
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
fast: false

metaM vacccoa c
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
is: HMDB06521
name: vaccenyl coenzyme A
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/9543677

http://identifiers.org/biomodels.db/MODEL1310110059#_1471283e_8f4a_4dcb_ab49_4a9b43f72e0a
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:766
type: Species
is: Q86YU0
boundary condition: true
name: CA7
constant: false
is: SBO:0000252

metaR CSNAT2m
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
modifier: MODEL1310110059#
reversible: true
fast: false
is: SBO:0000176
name: carnitine O-aceyltransferase, mitochondrial
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_0548436f_ede8_49e2_9536_807f55ca9f50
constant: false
is encoded by: hsa:55577
is: SBO:0000252
boundary condition: true
is: Q9UJ70
has only substance units: false
name: NAGK
type: Species
initial amount: NaN
initial concentration: NaN

metaR UDPACGALtl
reversible: true
name: udpacgal intracellular transport
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110059#

metaM c6crn c
is: HMDB00705
initial concentration: 1.0
name: hexanoyl carnitine
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C13H25NO4 CHARGE: 0
is: SBO:0000247
type: Species

metaR P4507A1r
reactant: MODEL1310110059#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
is described by: ECO:0000269
kinetic law: MODEL1310110059#
type: Reaction
reversible: false
modifier: MODEL1310110059#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.14.13.17

metaR DGSNt
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
name: deoyguanosine transport via diffusion
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_7bd919a5_32d2_4ba4_afc4_c04ac1bc026f
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57835
has only substance units: false
initial amount: NaN
name: SLC4A5
type: Species
is: SBO:0000252

metaR EX decdicrn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_5e487030_eeed_47e2_819a_cb8ed430b897
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: TXNRD1
is encoded by: hsa:7296
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_5a9e1be6_9e5c_4204_a3a6_7b499087c89f
has only substance units: false
has part: Q6NZ59
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:522
type: Species
is: SBO:0000297
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_e045faa6_75b0_441c_9e00_b1e3f3027a40
is: O60762
initial concentration: NaN
is encoded by: hsa:8813
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: DPM1
initial amount: NaN

metaR G14T17g
kinetic law: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110059#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM lpam m
is: HMDB00962
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial concentration: 1.0
initial amount: NaN
name: lipoamide
has only substance units: false
is: CHEBI:17460
constant: false
boundary condition: false
type: Species
is: SBO:0000247

metaM acngalgbside hs g
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
name: sialyl galactosylgloboside
constant: false
is: SBO:0000247
is: CHEBI:16523
type: Species
is: HMDB03406

http://identifiers.org/biomodels.db/MODEL1310110059#_acaf610c_0c7a_4e44_b920_a23aceac8273
boundary condition: true
type: Species
is: Q9NWU1
name: OXSM
is: SBO:0000252
has only substance units: false
is encoded by: hsa:54995
constant: false
initial amount: NaN
initial concentration: NaN

metaR r2313
is: SBO:0000185
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000

metaM stcrn m
constant: false
boundary condition: false
type: Species
name: stearoylcarnitine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00848
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
initial amount: NaN

metaM 3octdece1crn e
constant: false
type: Species
is: HMDB13336
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H47NO5 CHARGE: 0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 3-hydroxy-octadecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110059#_b96797fe_de1e_4d77_8bd8_830c911fd724
constant: false
name: LEFTY1
type: Species
has only substance units: false
is: O75610
initial amount: NaN
is encoded by: hsa:10637
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_472b679c_7d08_4a17_8e37_d036e50ab4bb
name: PPOX
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P50336
is encoded by: hsa:5498
constant: false
boundary condition: true
initial amount: NaN
type: Species

metaR 2HCO3 NAt
fast: false
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
modifier: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185
reversible: true

metaM dttp e
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37568
constant: false
name: dTTP(4-)
type: Species
is: HMDB01342
boundary condition: false
has only substance units: false

metaR ACCOAtr
is described by: ECO:0000000
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
name: acetyl-coa transport
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
is: SBO:0000185
reversible: true

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaM ppcoa m
name: Propanoyl-CoA
boundary condition: false
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247
has only substance units: false
is: C00100
type: Species
is: HMDB01275
is: CHEBI:57392
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_ba55c962_09fc_4fb4_afad_003c4477268f
constant: false
boundary condition: true
name: _AI440329_1_r
type: Species
is encoded by: hsa:AI440329
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_558a9aa8_e770_4b1c_ad5f_d838cc468b52
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8693
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: GALNT4
boundary condition: true
is: Q8N4A0

metaM doldp L r
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
name: Dolichol diphosphate, human liver homolog
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:15750

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR r2319
fast: false
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_74ae5587_b6a0_4ac1_82a4_cf72d431c6e2
type: Species
is: P28329
name: CHAT
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1103

metaR S6TASE21ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false

metaR IDOAASE1ly
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
product: MODEL1310110059#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
name: alpha-L-iduronidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction

metaR HS2ly
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
kinetic law: MODEL1310110059#
fast: false
type: Reaction
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.10.1.1

http://identifiers.org/biomodels.db/MODEL1310110059#_25407caa_eefc_4518_bde0_8a48365eee84
has only substance units: false
initial concentration: NaN
name: PDE9A
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:5152
is: SBO:0000252

metaR ASNNm
reactant: MODEL1310110059#
name: L-asparaginase (mitochondrial)
modifier: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.1.1
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110059#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm

metaM gacpail hs c
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
name: glucosaminyl-acylphosphatidylinositol
is: HMDB00128
has only substance units: false
constant: false
is: CHEBI:16344
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false

metaR MGCHrm
product: MODEL1310110059#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
modifier: MODEL1310110059#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
is version of: http://identifiers.org/ec-code/4.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110059#_3cce0d1f_3ddc_4304_8abf_d6301aec90ac
is: E9PB82
initial amount: NaN
constant: false
name: HSD17B4
is encoded by: hsa:3295
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_614cf267_5d5a_49a8_bab2_38b991170a97
constant: false
is: Q8TCD5
name: NT5C
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:30833

metaM hexdiac r
boundary condition: false
name: hexadecanediocacid
constant: false
is: SBO:0000247
initial amount: NaN
is: C08260
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110059#_b501c85a_bc18_4ac5_9364_ec69fd46ec29
initial concentration: NaN
is encoded by: hsa:154091
name: SLC2A12
boundary condition: true
is: SBO:0000252
is: Q8TD20
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM glc D c
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
is: HMDB00122
initial concentration: 1.0
is: SBO:0000247
name: D-glucose
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:4167
constant: false

metaM dttp c
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:37568
name: dTTP
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB01342
is: C00459

metaR r2318
product: MODEL1310110059#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

metaM 3octpencoa m
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 3,6,9,12,15-octadecapentenoylcoa

metaM cyst L c
name: L-cystathionine
is: CHEBI:17482
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H14N2O4S CHARGE: 0 INCHI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00916
is: SBO:0000247
is: HMDB00099
constant: false
has only substance units: false

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_68f2c9f4_ddaa_44dd_904f_d76f4bec220a
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:26266
constant: false
type: Species
name: SLC13A4
has only substance units: false
is: Q9UKG4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_992e69c0_80c6_4a9c_ba90_447d6ab4feb5
type: Species
has only substance units: false
is encoded by: hsa:1608
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: DGKG
initial concentration: NaN
is: P49619

metaR PPAt
kinetic law: MODEL1310110059#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110059#
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
reversible: false
is described by: ECO:0000000
name: Propionate transport, diffusion

http://identifiers.org/biomodels.db/MODEL1310110059#_1589ac2c_1aeb_4f0d_b8d4_50eeebfb4007
name: CPT1B
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1375
has only substance units: false
is: E9PCP2
type: Species
constant: false
boundary condition: true

metaR GCHOLAtx
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
name: bile acid intracellular transport
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185

metaR CYSASNNaEx
modifier: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
type: Reaction
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110059#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false

metaR PI345P5P
fast: false
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000000
modifier: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110059#
is: SBO:0000176
type: Reaction

metaR r2317
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
reversible: true
product: MODEL1310110059#
is described by: ECO:0000000

metaR DGK1
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction
reversible: true
modifier: MODEL1310110059#
product: MODEL1310110059#
name: deoxyguanylate kinase (dGMP:ATP)
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110059#
is: SBO:0000176

metaM fuc1p L c
has only substance units: false
is: HMDB01265
constant: false
initial amount: NaN
is: CHEBI:28319
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: SBO:0000247
type: Species
initial concentration: 1.0
name: L-Fucose 1-phosphate
boundary condition: false

metaM urcan c
is: CHEBI:17771
name: Urocanate
boundary condition: false
is: HMDB00301
has only substance units: false
type: Species
is: SBO:0000247
is: C00785
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785

metaR GLRASE
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reversible: true
kinetic law: MODEL1310110059#
name: glucuronolactone reductase
is: SBO:0000176
reactant: MODEL1310110059#

metaM c101coa c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: decenoylcoa
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: HMDB00651
has only substance units: false
type: Species
constant: false

metaR CSNAT2x
reactant: MODEL1310110059#
modifier: MODEL1310110059#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.137
fast: false
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.7

metaM dtmp m
is: SBO:0000247
is: CHEBI:26999
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
name: dTMP
boundary condition: false
is: HMDB01227

metaR PROSTGE1t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
type: Reaction
is: SBO:0000185
reactant: MODEL1310110059#
product: MODEL1310110059#
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_7e65e999_9a40_486f_a450_c44d69410f72
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ABAT
constant: false
is encoded by: hsa:18
initial amount: NaN
has only substance units: false

metaR ACCOAtn
reactant: MODEL1310110059#
name: acetyl-CoA transport, nuclear
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110059#

metaM dc2coa m
initial concentration: 1.0
boundary condition: false
name: trans-Dec-2-enoyl-CoA
is: CHEBI:61406
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false

metaR GLYCtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
name: glycerol transport
is described by: ECO:0000000
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_258c19d1_7da4_47e7_9414_7f40989dd387
has only substance units: false
name: ACADL
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:33
is: SBO:0000252
is: P28330

metaM glc D e
is: HMDB00122
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:4167
name: D-glucose
constant: false
type: Species
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaR FATP9t
name: fatty acid electroneutral transport
is described by: ECO:0000269
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000185
fast: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110059#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaR PHYTt
type: Reaction
product: MODEL1310110059#
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_b5d7a3c2_2872_4995_899d_9e0ae36ee4cf
is encoded by: hsa:4704
is: SBO:0000252
boundary condition: true
is: Q16795
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: NDUFA9

http://identifiers.org/biomodels.db/MODEL1310110059#_72296a1a_4a66_4360_bc16_484f6aa84765
has only substance units: false
name: GART
constant: false
is encoded by: hsa:2618
boundary condition: true
is: SBO:0000252
type: Species
is: Q59HH3
initial concentration: NaN
initial amount: NaN

metaM biocyt c
boundary condition: false
constant: false
name: Biocytin
has only substance units: false
is: HMDB03134
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species
initial amount: NaN
is: C05552

metaM lnlnca e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:32387
is: HMDB01388
constant: false
name: alpha-linolenate

metaR THRALANaEx
modifier: MODEL1310110059#
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110059#
is: SBO:0000185
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_b4697881_e55b_4bcd_9e32_51b41d854e17
name: TXNRD2
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10587
constant: false
has only substance units: false

metaM prgstrn e
name: progesterone
boundary condition: false
is: CHEBI:17026
is: SBO:0000247
initial amount: NaN
is: HMDB01830
initial concentration: 1.0
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_ba4f9387_ebba_46db_8a65_db0361465fec
is encoded by: hsa:56894
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: AGPAT3
is: Q9NRZ7
boundary condition: true

metaR r1691
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110059#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0456
reversible: false
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is: SBO:0000176
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.21
is version of: http://identifiers.org/ec-code/2.7.1.32
kinetic law: MODEL1310110059#
type: Reaction
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113

http://identifiers.org/biomodels.db/MODEL1310110059#_70374109_fe4b_48e8_9330_73f841886f0b
constant: false
has only substance units: false
name: CHST5
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23563

metaR LEUTA
type: Reaction
is: SBO:0000176
modifier: MODEL1310110059#
product: MODEL1310110059#
reversible: true
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
name: leucine transaminase
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaM pap c
initial concentration: 1.0
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: HMDB00061
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: adenosine 3',5'-bismonophosphate(4-)
is: SBO:0000247
is: CHEBI:58343
constant: false

metaM dece3coa m
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ea01cfdf_162f_4114_a84a_5cc136d4be3f
is encoded by: hsa:55825
boundary condition: true
has only substance units: false
is: Q9BY49
name: PECR
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaR r2202
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
reversible: true
product: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#

metaR GLCURtly
is described by: ECO:0000269
reactant: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
modifier: MODEL1310110059#
name: glucuronate transport into lysososme
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
kinetic law: MODEL1310110059#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_b4988f36_1972_4562_a7b4_bb3770fdf5eb
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR FAOXTC142TC122m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaR TTDCAtr
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
type: Reaction
name: tetradecanoate (transport)
reactant: MODEL1310110059#
is described by: ECO:0000269
fast: false

metaR FACOAL161
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (hexadecenoate)
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
fast: false

metaM acgam c
boundary condition: false
type: Species
is: CHEBI:17411
initial concentration: 1.0
name: N-acetyl-D-glucosamine
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
is: HMDB00215
is: SBO:0000247
has only substance units: false

metaM hdd2coa x
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: SBO:0000247
is: CHEBI:61526
is: HMDB03945
initial concentration: 1.0
type: Species
name: (E)-hexadec-2-enoyl-CoA(4-)
initial amount: NaN
has only substance units: false
constant: false

metaR GALASE14ly
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110059#
product: MODEL1310110059#
name: beta-galactosidase, lysosomal
is: SBO:0000176
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_26f85703_6270_4da6_9742_b2597c0ba24c
has part: Q13956
type: Species
has part: P16499
has part: B7Z9T9
name: PDE6A:PDE6H:PDE6B
is encoded by: hsa:5145
initial amount: NaN
is encoded by: hsa:5149
constant: false
boundary condition: true
is: SBO:0000297
has only substance units: false
is encoded by: hsa:5158
initial concentration: NaN

metaR GGH 5THFe
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
modifier: MODEL1310110059#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: Gamma-glutamyl hydrolase (5THF), extracellular
reactant: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction

metaM 4hglusa m
has only substance units: false
constant: false
name: L-4-hydroxyglutamic semialdehyde
initial concentration: 1.0
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: HMDB06556
initial amount: NaN
is: SBO:0000247
is: CHEBI:27809
boundary condition: false
type: Species

metaM glc D g
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
is: HMDB00122
initial amount: NaN
initial concentration: 1.0
is: CHEBI:4167
has only substance units: false
is: SBO:0000247
boundary condition: false
name: D-glucose

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

metaR r2201
reactant: MODEL1310110059#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR GLCt2 2
reactant: MODEL1310110059#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
product: MODEL1310110059#
name: D-glucose transport in via proton symport
reversible: true
fast: false
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_d516a473_d1d4_40e1_b04d_60838dd6efa9
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: SLC33A1
is encoded by: hsa:9197
is: O00400
boundary condition: true

metaR FAOXC141C141OHm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_44724870_8c99_4ed6_8d3c_531b4a614dd6
constant: false
is encoded by: hsa:5148
name: PDE6G
is: SBO:0000252
is: P18545
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_df0a4393_e224_4790_9f7e_d9b9372b7f92
is: SBO:0000252
initial amount: NaN
name: NDUFS2
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4720
type: Species
has only substance units: false
is: B7Z792

metaM lnlnca c
boundary condition: false
initial concentration: 1.0
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: SBO:0000247
has only substance units: false
is: CHEBI:32387
constant: false
initial amount: NaN
type: Species
is: HMDB01388

metaM prgstrn c
constant: false
boundary condition: false
type: Species
is: CHEBI:17026
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB01830
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
has only substance units: false
name: progesterone

metaM 3odcoa m
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 3-Oxodecanoyl-CoA
initial amount: NaN
is: HMDB03939
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: CHEBI:28528

metaR S6T5g
product: MODEL1310110059#
fast: false
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110059#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_8d2c6443_e4da_4371_a8a1_f4c6504a985b
constant: false
has only substance units: false
initial amount: NaN
name: PLCH2
is: O75038
is: SBO:0000252
is encoded by: hsa:9651
initial concentration: NaN
boundary condition: true
type: Species

metaR DOPASULT
product: MODEL1310110059#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
name: Dopamine Sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.1

http://identifiers.org/biomodels.db/MODEL1310110059#_dd2297eb_5aae_475a_8049_c218e8e7a78f
initial amount: NaN
has only substance units: false
name: MTMR1
initial concentration: NaN
is encoded by: hsa:8776
is: Q13613
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaR r2200
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000185
reversible: true
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110059#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaM ksi deg9 l
is: HMDB00143
is: SBO:0000247
has only substance units: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
boundary condition: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 9
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r1401
is version of: http://identifiers.org/ec-code/3.2.1.35
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
name: Facilitated diffusion
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.51
is version of: http://identifiers.org/ec-code/2.7.10.1
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false

metaM stcrn c
name: stearoylcarnitine
type: Species
initial concentration: 1.0
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00848
initial amount: NaN
boundary condition: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR TDPm
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: thiamin pyrophosphatase, mitochondrial
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
fast: false
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaM 56dura c
constant: false
initial amount: NaN
name: 5,6-dihydrouracil
is: CHEBI:15901
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: HMDB00076
is: SBO:0000247
type: Species

metaM msa m
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:33190
initial concentration: 1.0
name: 3-oxopropanoate
type: Species
is: HMDB11111
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: SBO:0000247

metaR r1683
is: SBO:0000185
type: Reaction
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110059#
reversible: false
name: Y+LAT2 Utilized transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_a5dec879_1adc_49b4_8e54_ebf0b5b91ff9
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR r0731
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110059#
is: SBO:0000176
type: Reaction
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
reversible: false

metaM HC01602 c
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:57454
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaM xan c
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: C00385
is: CHEBI:17712
name: Xanthine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00292
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_7db8879f_fa0a_4a52_9110_3c17b74f0d59
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:117248
has only substance units: false
name: GALNTL2
is: Q8N3T1
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_ab77cb69_6487_4c54_b354_90ce37fbc67d
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: Q9BYZ2
has only substance units: false
name: LDHAL6B
is encoded by: hsa:92483
initial concentration: NaN
boundary condition: true

metaR PROSTGF2t
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
name: prostaglandin uniport
type: Reaction
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_83603846_9c73_4520_9181_ab358bf6c2d9
is: SBO:0000252
boundary condition: true
is: A3KLL5
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:481
name: ATP1B1

http://identifiers.org/biomodels.db/MODEL1310110059#_b3b63732_1f12_4d09_84d0_e44c9228a8c8
initial amount: NaN
name: ESCO2
is: Q56NI9
is encoded by: hsa:157570
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaR r1682
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR ECOAH9m
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM HC02210 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
type: Species
name: prostaglandin-d3
initial concentration: 1.0
is: CHEBI:34939
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

metaR FAOXC103C102m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR r0732
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
reversible: false
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_13398cbb_1ef9_4d1c_850a_1504ac61300b
is: Q8WVQ1
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:124583
constant: false
name: CANT1
initial amount: NaN

metaR CSNATp
fast: false
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110059#
is described by: ECO:0000304
reversible: true

metaR r2031
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110059#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110059#

metaM strch2 e
is: HMDB00122
type: Species
notes: FORMULA: C18H32O16 CHARGE: 0
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
boundary condition: false
is: CHEBI:4167

metaM nicrnt c
constant: false
name: Nicotinate D-ribonucleotide
type: Species
is: CHEBI:57502
initial amount: NaN
is: C01185
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01132

metaR F1PGT
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.30
product: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
is described by: ECO:0000000
fast: false
name: fucose-1-phosphate guanylyltransferase
type: Reaction
kinetic law: MODEL1310110059#

metaR PIter
kinetic law: MODEL1310110059#
name: phosphate transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000212
modifier: MODEL1310110059#
product: MODEL1310110059#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110059#

metaM retinal c
initial amount: NaN
name: retinal
is: HMDB01358
constant: false
has only substance units: false
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15035

metaM chsterol m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species
is: HMDB00067
name: cholesterol
is: CHEBI:16113
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

metaM tre e
is: C01083
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:16551
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Trehalose
is: HMDB00975
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083

metaR CYTK3n
fast: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110059#
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110059#

metaR C161OHc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaR r1681
modifier: MODEL1310110059#
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110059#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110059#

metaR C8DCc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_b71caa11_2554_4a16_9b39_4f83b6e1d697
has only substance units: false
is: SBO:0000252
name: ABCA1
is encoded by: hsa:19
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: O95477

http://identifiers.org/biomodels.db/MODEL1310110059#_7a792a11_b467_4a44_8cc8_c5865de95d5e
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:84105
name: PCBD2
type: Species
initial amount: NaN
is: Q9H0N5
initial concentration: NaN

metaM cs b deg3 l
constant: false
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
is: HMDB02704
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: CHEBI:21338
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_13fde211_8e3b_456a_b9a9_ff2ad7444cef
is: P21439
is encoded by: hsa:5244
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: ABCB4
type: Species
boundary condition: true

metaR r2030
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110059#
modifier: MODEL1310110059#

metaM dc2coa x
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
constant: false
is: HMDB01168
name: trans-Dec-2-enoyl-CoA
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR ALDD2y
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
reactant: MODEL1310110059#
reversible: false
type: Reaction
modifier: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaM cdp m
is: CHEBI:58069
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01546
constant: false
initial concentration: 1.0
type: Species
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

http://identifiers.org/biomodels.db/MODEL1310110059#_cd68c7ad_4a11_4402_b93c_4147be9791af
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4598
name: MVK
boundary condition: true
initial concentration: NaN
type: Species
is: B2RDU6

metaM acgam l
initial concentration: 1.0
type: Species
is: HMDB00215
name: N-acetyl-D-glucosamine
has only substance units: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
initial amount: NaN
is: CHEBI:17411
constant: false

metaM chsterol l
initial concentration: 1.0
type: Species
is: SBO:0000247
name: cholesterol
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
constant: false
is: CHEBI:16113
boundary condition: false
initial amount: NaN

metaR FAOXC164C163x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaR FACOAL170
reversible: true
modifier: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is: SBO:0000176
reactant: MODEL1310110059#

metaR r0730
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is described by: ECO:0000000
reversible: false
product: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
modifier: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR PItg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110059#
fast: false
product: MODEL1310110059#
reversible: false
is: SBO:0000185
name: phosphate transport, Golgi apparatus
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#

metaM ametam c
constant: false
has only substance units: false
name: S-Adenosylmethioninamine
is: SBO:0000247
is: HMDB00988
boundary condition: false
is: CHEBI:57443
initial amount: NaN
type: Species
is: C01137
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
initial concentration: 1.0

metaM c12dc c
is: SBO:0000247
name: dodecanedioyl carnitine
is: HMDB00623
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C19H34NO6 CHARGE: -1

metaR CYOOm3
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.9.3.1
fast: false
reversible: false
name: cytochrome c oxidase, mitochondrial Complex IV
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_4d6cfa7c_fd9f_4997_8b49_5bd37eb43a95
initial concentration: NaN
is: SBO:0000252
name: GRHPR
is: Q9UBQ7
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:9380
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_2fd88990_daa0_4cb6_916a_2c6beab00402
is encoded by: hsa:55312
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: B2RDZ2
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: RFK

metaR PYRt2m
modifier: MODEL1310110059#
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
fast: false
name: pyruvate mitochondrial transport via proton symport
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD

metaR CSNATr
reactant: MODEL1310110059#
is described by: ECO:0000000
fast: false
product: MODEL1310110059#
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
name: carnitine O-acetyltransferase

metaR NADPHtru
product: MODEL1310110059#
fast: false
name: NADPH transporter, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110059#

metaM 12ppd S c
has only substance units: false
type: Species
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
constant: false
initial amount: NaN
is: CHEBI:29002
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: (S)-propane-1,2-diol
is: HMDB06213

metaR r0735
kinetic law: MODEL1310110059#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110059#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_0867a568_0de7_47e0_97d4_df04ccd5361e
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10993
is: SBO:0000252
is: P20132
type: Species
constant: false
name: SDS
has only substance units: false
boundary condition: true

metaR PYRt2p
reactant: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
is described by: ECO:0000269
name: pyruvate peroxisomal transport via proton symport
reversible: true
fast: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#

metaM nadph c
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00005
is: HMDB00221
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_65e1e2a9_671e_4c98_aa43_aa59a879cd4c
is: SBO:0000252
is encoded by: hsa:54677
boundary condition: true
is: E7EQF2
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: CROT
constant: false

metaM lnlncgcoa r
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
initial concentration: 1.0
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
constant: false
initial amount: NaN
is: CHEBI:57363
type: Species
has only substance units: false

metaM ach e
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
name: acetylcholine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15355
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_b6057118_2dbd_4f4d_aee0_ee84e03d8043
name: SULT1E1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6783
is: P49888
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaR DECDICRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_7fce688e_dc5c_4987_b5d7_060238d2f5c8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:122481
constant: false
name: AK7
type: Species
has only substance units: false
initial concentration: NaN
is: Q96M32
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_6b974c5b_8dc2_464c_9658_88a5b9753855
type: Species
initial concentration: NaN
is: SBO:0000252
name: ALDH1A3
initial amount: NaN
constant: false
is: P47895
has only substance units: false
is encoded by: hsa:220
boundary condition: true

metaM cdp n
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
boundary condition: false
name: CDP(3-)
is: CHEBI:58069
is: HMDB01546
initial concentration: 1.0
constant: false

metaR r1687
kinetic law: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110059#
type: Reaction

metaM ksii core4 pre3 g
notes: FORMULA: C55H89N5O38X CHARGE: -1
constant: false
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
has only substance units: false
initial concentration: 1.0
is: C00130
is: SBO:0000247
type: Species
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 3

http://identifiers.org/biomodels.db/MODEL1310110059#_d961e54a_e7fa_4bf9_b0b9_61cb6c51e8c9
name: CHAT
is: Q6LEN6
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:1103
initial concentration: NaN
type: Species

metaR R group phosphotase 1
name: R group phosphotase 1
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:

metaR ADNt
is: SBO:0000185
name: adenosine facilated transport in cytosol
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_93c0c912_97f7_4d63_a9c0_97f34302ed0b
constant: false
has only substance units: false
is: P20594
is: SBO:0000252
name: NPR2
is encoded by: hsa:4882
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaR GTHDH
kinetic law: MODEL1310110059#
type: Reaction
fast: false
name: Glutathione dehydrogenase (dehydroascorbate reductase)
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
is: SBO:0000176
product: MODEL1310110059#
reactant: MODEL1310110059#

metaM 10fthf c
is: SBO:0000247
boundary condition: false
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
initial amount: NaN
type: Species
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
constant: false
is: C00234
has only substance units: false

metaR GCCcm
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110059#
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_4ab89d88_d67f_42a7_a90f_10ef80a5980d
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:2182
initial concentration: NaN
is: Q5JWV8
boundary condition: true
type: Species
is: SBO:0000252
name: ACSL4

metaM s2l2n2m2m l
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C84H136N6O62 CHARGE: -2
has only substance units: false
initial concentration: 1.0
name: de-Fuc form of PA6 (w/o peptide linkage)
is: CHEBI:30825
is: HMDB00573

metaR FADH2tx
is described by: ECO:0000000
type: Reaction
fast: false
name: FADH2 transporter, peroxisomal
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185

metaR PYRt2r
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reactant: MODEL1310110059#
reversible: true
name: pyruvate reversible transport via proton symport

metaR GAMt1r
name: glucosamine transport (uniport)
type: Reaction
product: MODEL1310110059#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000269
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
fast: false
modifier: MODEL1310110059#

metaR r0733
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000000
reversible: false
fast: false
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_23ea6f61_0162_40c3_87f7_486597e770a5
type: Species
initial concentration: NaN
is: B1AN63
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NMNAT1
is encoded by: hsa:64802

metaM ach c
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
initial concentration: 1.0
is: HMDB00895
is: SBO:0000247
is: CHEBI:15355
initial amount: NaN
boundary condition: false
type: Species
constant: false

metaR PA HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
name: phosphatidate transport, nuclear
reversible: true

metaR r1685
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM 5htrp c
has only substance units: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: 5-hydroxy-L-tryptophan
is: HMDB00472
boundary condition: false
is: CHEBI:17780

http://identifiers.org/biomodels.db/MODEL1310110059#_fa4e3f4f_9ade_444d_a0f9_dd0946d31c6b
is: SBO:0000252
name: PIGP
initial amount: NaN
constant: false
is encoded by: hsa:51227
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P57054
type: Species

metaR r0734
kinetic law: MODEL1310110059#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000

metaM dopa e
is: SBO:0000247
name: dopaminium(1+)
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
type: Species
is: HMDB00073
boundary condition: false
is: CHEBI:59905
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_162dad36_121b_4d35_9c46_6fd5e0e13487
is encoded by: hsa:9245
is: O95395
constant: false
boundary condition: true
name: GCNT3
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM HC02210 e
name: prostaglandin-d3
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:34939
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_bd862355_655f_46f0_9124_c984500e1609
boundary condition: true
constant: false
is encoded by: hsa:AV717590
is: SBO:0000252
name: _AV717590_1_c
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN

metaM hdd2coa c
name: trans-Hexadec-2-enoyl-CoA
has only substance units: false
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: C05272
is: HMDB03945
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:61526

metaR FRDPtc
reversible: true
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
name: lipid, flip-flop intracellular transport
fast: false

metaR r1684
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
modifier: MODEL1310110059#
product: MODEL1310110059#

metaM 10fthf e
name: 10-formyltetrahydrofolate(2-)
is: HMDB00972
initial amount: NaN
is: SBO:0000247
is: CHEBI:57454
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaR ASPTAm
is described by: ECO:0000269
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
is: SBO:0000176
reversible: true
name: aspartate transaminase
reactant: MODEL1310110059#
product: MODEL1310110059#

metaR RE3568C
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000000
name: RE3568
reactant: MODEL1310110059#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_54426926_c6c2_4a52_9eb4_79f1c1da6a05
is: Q5MY95
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:377841
name: ENTPD8
is: SBO:0000252
initial amount: NaN

metaR PItn
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110059#
fast: false
product: MODEL1310110059#
reversible: true
name: phosphate transport, nuclear
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaM 3mop m
has only substance units: false
is: CHEBI:28654
initial concentration: 1.0
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: HMDB00491
type: Species
constant: false

metaR RE3000M
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
is: SBO:0000176
name: RE3000
reversible: true

metaR MALTSULtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110059#
type: Reaction
name: Malate:thiosulfate antiport, mitochondrial
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
is described by: ECO:0000269
is: SBO:0000185

metaR r0145
is version of: http://identifiers.org/ec-code/1.8.3.1
modifier: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
fast: false
type: Reaction
reversible: true
product: MODEL1310110059#

metaR SERHL
product: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.1.17
reactant: MODEL1310110059#
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: L-Serine hydro-lyase
kinetic law: MODEL1310110059#

metaR r0739
reversible: true
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:

metaR GALASE5ly
fast: false
name: beta-galactosidase, lysosomal
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_fb35eb34_3b6a_4dbc_bf51_c2ff49ea01ca
type: Species
boundary condition: true
is: Q9Y666
has only substance units: false
is encoded by: hsa:10723
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC12A7
is: SBO:0000252

metaM chsterol r
is: HMDB00067
name: cholesterol
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16113
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaR S6TASE22ly
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
name: galactose-6-sulfate sulfatase, lysosomal
fast: false
modifier: MODEL1310110059#

metaR RE1519M
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1519
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
is described by: ECO:0000000

metaR r0885
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.38
product: MODEL1310110059#
reversible: true

metaM hdd2coa m
type: Species
initial amount: NaN
constant: false
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
initial concentration: 1.0
boundary condition: false
name: trans-Hexadec-2-enoyl-CoA
is: HMDB03945
has only substance units: false
is: SBO:0000247

metaR NADPtru
name: NADP transporter, endoplasmic reticulum
is: SBO:0000185
reversible: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_e970646c_72a9_4883_b937_1b5b390544c6
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:AA177072
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AA177072_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_e697e2b5_74b9_4106_b1e9_9302dae1bce3
boundary condition: true
is: Q9Y5X9
name: LIPG
is encoded by: hsa:9388
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_1fffe98b_5329_4c1a_a652_036134a180dc
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: O00746
boundary condition: true
name: NME4
has only substance units: false
constant: false
type: Species
is encoded by: hsa:4833

metaR 2MB2COAc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaM hgentis c
type: Species
initial concentration: 1.0
name: homogentisate
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
is: SBO:0000247
is: CHEBI:16169
is: HMDB00130
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

metaR C6CRNtcx
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaR AG13T17g
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_071699a4_6fad_4e19_acbd_682f9be4f45f
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is: Q674R7
name: ATG9B
is encoded by: hsa:285973
initial concentration: NaN
has only substance units: false

metaR 3HBCOAHLm
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reactant: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_86cb1f53_90c5_4f2c_946b_76daba14d3bb
boundary condition: true
name: B3GNT1
is encoded by: hsa:11041
is: O43505
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaM CE4794 m
is: CHEBI:57923
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: cis-6-dodecenoyl-CoA
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794

metaM gacpail hs r
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: glucosaminyl-acylphosphatidylinositol
is: HMDB00128
is: SBO:0000247
is: CHEBI:16344
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

metaR TDCHOLAte
kinetic law: MODEL1310110059#
fast: false
name: bile acid intracellular transport
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
reversible: true

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR FUCtly
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
name: L-fucose efflux from lysosome
reactant: MODEL1310110059#
is: SBO:0000185

metaR AHEXASEly
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR 5ADTSTSTERONESte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110059#
name: sulfonated testosterone transport
fast: false
type: Reaction
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_060b32a6_7b9e_439d_a371_58f75feeb4b3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:130752
constant: false
is: Q5I0G3
name: MDH1B
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaM 3spyr c
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
initial amount: NaN
is: CHEBI:57940
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB04045
constant: false
name: 3-sulfonatopyruvate(2-)

metaR BILIRUBtr
reactant: MODEL1310110059#
reversible: true
type: Reaction
name: lipid, flip-flop intracellular transport
product: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false

metaR FAOXC103C102x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_12de5856_64ab_4e83_976b_dc535a236785
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CA12
is encoded by: hsa:771
type: Species
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_4146500e_562c_4db1_8ab4_f34adb9566cb
is encoded by: hsa:5296
initial concentration: NaN
boundary condition: true
has part: P42336
is encoded by: hsa:5290
type: Species
is: SBO:0000297
name: PIK3CA:PIK3R2
initial amount: NaN
constant: false
has only substance units: false
has part: O00459

metaM cs a deg4 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
type: Species
is: SBO:0000247
is: CHEBI:16953
constant: false
notes: FORMULA: C31H49NO29S CHARGE: -2
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00812
initial concentration: 1.0

metaM ksi deg31 l
boundary condition: false
is: CHEBI:16953
is: HMDB00812
constant: false
type: Species
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 31
initial concentration: 1.0
is: SBO:0000247

metaM C05279 m
is: HMDB11123
type: Species
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
constant: false
initial amount: NaN
is: CHEBI:28387

metaR PROSTGI2tr
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction
name: Prostaglandin I2 transport (ER)
product: MODEL1310110059#
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110059#

metaM ksii core2 deg4 l
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C58H95N5O43SX CHARGE: -1
is: CHEBI:16953
is: HMDB00812
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_6b0c9ffb_281c_45b3_b90a_892bc0d8d8ba
is: SBO:0000252
is: B3KN25
is encoded by: hsa:10390
constant: false
initial concentration: NaN
name: CEPT1
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR ADA
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110059#
name: Adenosine deaminase
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.5.4.4
is described by: ECO:0000269

metaR FAOXC185m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaM dtmp c
has only substance units: false
boundary condition: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP
initial amount: NaN
is: C00364
initial concentration: 1.0
constant: false
is: CHEBI:26999
is: HMDB01227
type: Species
is: SBO:0000247

metaR r0149
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.39
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaR FORtr
reversible: true
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: FOR transporter, endoplasmic reticulum
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

metaM camp c
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00058
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
is: CHEBI:58165
is: SBO:0000247
name: 3',5'-cyclic AMP(1-)
type: Species
has only substance units: false
initial concentration: 1.0

metaR r0881
is: SBO:0000185
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110059#
name: Active transport
fast: false
product: MODEL1310110059#

metaR NDPK9n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reversible: true

metaM acgam r
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
is: SBO:0000247
is: CHEBI:17411
initial concentration: 1.0
has only substance units: false
name: N-acetyl-D-glucosamine
initial amount: NaN
type: Species
is: HMDB00215

metaR S4TASE4ly
is version of: http://identifiers.org/ec-code/3.1.6.12
is: SBO:0000176
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110059#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110059#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_1ff9f0ca_fc3b_4f3c_b682_4eaf2eb246b9
is: SBO:0000252
type: Species
initial concentration: NaN
is: P16066
boundary condition: true
name: NPR1
initial amount: NaN
constant: false
is encoded by: hsa:4881
has only substance units: false

metaR CYTK13n
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
product: MODEL1310110059#
name: cytidylate kinase (dCMP,dATP),nuclear
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR RE3244R
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reactant: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
name: RE3244
fast: false
product: MODEL1310110059#

metaR r2320
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaM vacccoa m
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: vaccenyl coenzyme A
is: HMDB06521
is: http://identifiers.org/pubchem.compound/9543677
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_a69762a8_9493_45f1_b93d_f8daa28f35c9
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _FLJ44968_1_m
constant: false
has only substance units: false
is encoded by: hsa:FLJ44968
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_efc87070_cbf4_419d_b720_e3a22155eab7
constant: false
initial concentration: NaN
has only substance units: false
is: Q8NEB9
boundary condition: true
name: PIK3C3
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5289

http://identifiers.org/biomodels.db/MODEL1310110059#_b1d6e995_2b40_4389_b175_42b16feadd3d
initial concentration: NaN
is: P08236
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: GUSB
is: SBO:0000252
is encoded by: hsa:2990
has only substance units: false

metaM tetdec2coa c
name: tetradecadienoylcoa
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB02014
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110059#_51ed3fb3_0e60_46d8_b7dc_49adee422254
is: SBO:0000252
type: Species
constant: false
name: ADCY5
initial amount: NaN
initial concentration: NaN
is: O95622
has only substance units: false
is encoded by: hsa:111
boundary condition: true

metaR NAIt
modifier: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
type: Reaction
name: Na+ / iodide cotransport
is described by: ECO:0000269
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
reversible: true
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_c4f1c133_ec4e_4429_a517_d5cf9f384a5e
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: MTMR3
is encoded by: hsa:8897
is: SBO:0000252

metaR C3DCe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_15fdc770_36fc_4ea1_8d27_686e722cbdfb
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:5091
is: SBO:0000252
name: PC
constant: false

metaR FAOXC16C16OHm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_7e0e168d_aa9c_4ff1_a86f_d7af70d01723
is encoded by: hsa:8854
initial amount: NaN
initial concentration: NaN
name: ALDH1A2
is: B4DZR2
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaM Asn X Ser Thr r
is: SBO:0000247
has only substance units: false
name: protein-linked asparagine residue (N-glycosylation site)
is: C01342
is: HMDB00051
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: CHEBI:28938
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_0b063b97_128e_4525_ab03_28e1aac95fb7
constant: false
name: INPP5J
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:27124
has only substance units: false
type: Species

metaR FAOXC226C205m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_cd965576_ad30_4582_86ba_e0b3e484a3f9
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:22978
is: P49902
boundary condition: true
constant: false
name: NT5C2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_36804df2_e9a7_4ecd_82bc_925176f05ec3
constant: false
name: HAO2
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:51179
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_806455f1_5ace_4883_b412_0ce49ffb6bd5
initial concentration: NaN
name: NDUFB8
is: O95169
is encoded by: hsa:4714
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR TYRCBOX
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
reactant: MODEL1310110059#
reversible: false
fast: false
product: MODEL1310110059#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110059#
name: L-Tyrosine carboxy-lyase

http://identifiers.org/biomodels.db/MODEL1310110059#_933c9c06_35be_408a_a6ea_e8ec00f38f65
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:115286
is: SBO:0000252
initial concentration: NaN
name: SLC25A26
type: Species
is: Q70HW3

metaR RTOTAL3FATPc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaM hspg e
boundary condition: false
is: SBO:0000247
constant: false
name: heparan sulfate proteoglycan
is: CHEBI:32366
is: HMDB02259
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM 3ddcrn e
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: HMDB00791
is: C02838
name: 3-hydroxydodecanoylcarnitine
notes: FORMULA: C19H37NO5 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1b5ee819_cb6b_4205_a4f0_88ecb25a164c
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:27034
name: ACAD8
is: Q6ZWP6

http://identifiers.org/biomodels.db/MODEL1310110059#_382a4bba_3d36_4573_86fc_e7e04deb19c3
constant: false
is: B3KNC1
boundary condition: true
is encoded by: hsa:51733
is: SBO:0000252
name: UPB1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_26704bd1_3129_4acb_8da4_fa638d7f286f
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SLC6A6
is encoded by: hsa:6533
is: SBO:0000252
is: Q9BRI2

metaR q10h2tc
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: transport of ubiquinol into cytosol
type: Reaction
reactant: MODEL1310110059#
reversible: true
is described by: ECO:0000134
is: SBO:0000185

metaR CSNATm
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
name: carnitine O-aceyltransferase, mitochondrial
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_3ee8e1ba_aa34_4e34_81cc_5b1e4e25a583
is: SBO:0000252
is encoded by: hsa:509
name: ATP5C1
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q6I9V2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_49e49f6b_31b0_41cd_9626_389f36883bf4
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:AA977580
name: _AA977580_1_c
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM lgnccoa c
has only substance units: false
type: Species
is: HMDB06526
boundary condition: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
initial amount: NaN
name: lignocericyl coenzyme A
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r0208
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.4.1.1
reversible: true
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_26b87252_99cb_4c3e_952c_3c2317c16bef
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9NP59
is encoded by: hsa:30061
boundary condition: true
name: SLC40A1

metaM c81coa c
has only substance units: false
is: HMDB03949
initial amount: NaN
is: C05276
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
type: Species
name: octenoylcoa
boundary condition: false
constant: false

metaR CPPPGO
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
name: coproporphyrinogen oxidase (O2 required)
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.3.3.3
is: SBO:0000176

metaR AG13T7g
reversible: false
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
modifier: MODEL1310110059#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaM retinal 11 cis c
initial amount: NaN
type: Species
is: CHEBI:16066
initial concentration: 1.0
boundary condition: false
is: HMDB02152
has only substance units: false
is: SBO:0000247
name: 11-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false

metaR NMNATr
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nicotinamide-nucleotide adenylyltransferase
fast: false
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000269
kinetic law: MODEL1310110059#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.1

metaM CE5162 r
is: SBO:0000247
is: CHEBI:57923
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
type: Species
has only substance units: false
name: trans,cis-2,9-octadecadienoyl-CoA
initial concentration: 1.0
initial amount: NaN
constant: false

metaR GMPR
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
name: GMP reductase
fast: false
is version of: http://identifiers.org/ec-code/1.7.1.7
is: SBO:0000176
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_d982a4d0_8c7b_4217_9dbc_41b991f232be
is: O15427
name: SLC16A3
type: Species
initial concentration: NaN
is encoded by: hsa:9123
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_50b122f1_b456_4da9_89b7_bd1c608e3101
boundary condition: true
is encoded by: hsa:23236
initial amount: NaN
type: Species
name: PLCB1
initial concentration: NaN
constant: false
is: Q9NQ66
has only substance units: false
is: SBO:0000252

metaR S6T13g
modifier: MODEL1310110059#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_a69379eb_74b8_4f6f_8d0f_5f9b769f4c1a
is: P22392
initial concentration: NaN
initial amount: NaN
name: NME2
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4831
type: Species

metaM m2emgacpail hs r
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:24636
is: C00080
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ba964af4_090f_4b36_ba21_1e249d47af90
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: C9JT23
type: Species
is encoded by: hsa:126328
constant: false
boundary condition: true
name: NDUFA11
has only substance units: false

metaM dec47dicoa m
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: 4,7-decadienoylcoa
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110059#_5a53d61f_d7d6_49be_ab15_ba57d18812b7
boundary condition: true
is encoded by: hsa:114112
is: Q86VQ6
initial amount: NaN
initial concentration: NaN
name: TXNRD3
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaM sbcoa x
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
has only substance units: false
boundary condition: false
type: Species
name: suberylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966

metaM gdpfuc g
initial amount: NaN
is: HMDB01095
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: CHEBI:57984
boundary condition: false
constant: false
type: Species
name: GDP-L-fucose(2-)

metaM lnlncacrn c
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: alpha-linolenyl carnitine
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
is: HMDB06319
initial concentration: 1.0
boundary condition: false

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaM c10crn e
initial amount: NaN
type: Species
name: decanoyl carnitine
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00651
is: SBO:0000247
boundary condition: false
notes: FORMULA: C17H33NO4 CHARGE: 0

metaM prgnlone c
is: CHEBI:16581
is: HMDB00253
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
initial concentration: 1.0
name: pregnenolone
initial amount: NaN

metaM tdchola x
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:9407
constant: false
is: SBO:0000247
name: taurochenodeoxycholate
is: HMDB00951
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_d5b2a9ff_60ec_456b_a5a6_c47ccccc6bdc
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P32019
is encoded by: hsa:3633
name: INPP5B

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_42666aee_8c7e_4ec4_b8f4_9e5551fb2d27
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:79966
constant: false
boundary condition: true
name: SCD5
is: Q86SK9
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_19d77695_9adb_4c33_af04_7643cdc5d6e6
type: Species
boundary condition: true
is: Q96PE3
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3631
name: INPP4A

metaM bildglcur c
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR H2O2tn
name: hydrogen peroxide nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
fast: false
is: SBO:0000185
reactant: MODEL1310110059#
type: Reaction
reversible: true
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000

metaR HMGLm
is: SBO:0000176
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.1.3.4
type: Reaction
reversible: false
is described by: ECO:0000134
name: hydroxymethylglutaryl-CoA lyase
fast: false

metaM glyc3p c
initial amount: NaN
is: CHEBI:57597
is: C00093
constant: false
initial concentration: 1.0
is: HMDB00126
type: Species
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
is: SBO:0000247
name: Glycerol 3-phosphate

metaM fadh2 x
name: FADH2(2-)
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
is: CHEBI:58307
has only substance units: false
is: HMDB01197
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_9b33231f_5537_45f0_9000_dd383ddeebd3
is encoded by: hsa:AI469183
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: _AI469183_1_x
is: SBO:0000252

metaM man1p c
boundary condition: false
is: HMDB06330
name: D-Mannose 1-phosphate
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:35374
is: SBO:0000247

metaM tettet6coa c
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205481
is: C16171
boundary condition: false
constant: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: SBO:0000247
type: Species
name: tetracosatetraenoyl coenzyme A
is: HMDB06516
has only substance units: false

metaR CYTK10
type: Reaction
is: SBO:0000176
reactant: MODEL1310110059#
name: cytidylate kinase (CMP,dGTP)
fast: false
is described by: ECO:0000269
product: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110059#

metaM nad x
name: Nicotinamide adenine dinucleotide
is: HMDB00902
has only substance units: false
constant: false
type: Species
is: C00003
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57540

http://identifiers.org/biomodels.db/MODEL1310110059#_cc5ab6b1_45f7_4a39_8644_d1a54ec498e8
boundary condition: true
is: B4DFS7
name: FUT8
has only substance units: false
type: Species
is encoded by: hsa:2530
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_a37e233d_32e6_4f9e_a906_72259c8750bf
name: AK5
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:26289
type: Species

metaM 3octdectecoa x
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
type: Species
constant: false
name: 3,6,9,12-octadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110059#_0d8796fc_ac8c_4b9f_a521_f81818d60ccf
type: Species
initial amount: NaN
is encoded by: hsa:4048
constant: false
has only substance units: false
initial concentration: NaN
name: LTA4H
is: P09960
boundary condition: true
is: SBO:0000252

metaM HC02217 c
has only substance units: false
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
is: CHEBI:27647
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR NMNATn
fast: false
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES:IT
reversible: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.1
kinetic law: MODEL1310110059#
is: SBO:0000176
name: nicotinamide-nucleotide adenylyltransferase

metaR r1090
type: Reaction
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

metaR HEXDCRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_42c61f7c_5c40_4435_9f82_febcc06ca663
has only substance units: false
boundary condition: true
type: Species
name: VNN3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55350
initial concentration: NaN
constant: false

metaM c10crn c
name: decanoyl carnitine
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C17H33NO4 CHARGE: 0
is: SBO:0000247
type: Species
constant: false
is: HMDB00651

metaM CE5854 e
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:27485
initial amount: NaN
is: HMDB02710
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
name: gama-CEHC-glucuronide

metaM c12dccoa x
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
initial concentration: 1.0
boundary condition: false
name: dodecanedioylcoa
is: HMDB03712

http://identifiers.org/biomodels.db/MODEL1310110059#_5fcb0a39_767e_4f3b_b14a_dde12f62f3f5
initial amount: NaN
constant: false
type: Species
name: AQP8
has only substance units: false
is encoded by: hsa:343
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O94778

http://identifiers.org/biomodels.db/MODEL1310110059#_9b08f730_15c5_4ec1_9944_c113d905aa8e
is: SBO:0000252
is: P21912
boundary condition: true
is encoded by: hsa:6390
initial concentration: NaN
initial amount: NaN
type: Species
name: SDHB
has only substance units: false
constant: false

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM hdcea r
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB03229
boundary condition: false
has only substance units: false
name: palmitoleate
is: CHEBI:32372
constant: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_6085847e_24c8_4982_9a56_66bf8f61c969
type: Species
is encoded by: hsa:AA081045
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _AA081045_1_c
initial amount: NaN
is: SBO:0000252
constant: false

metaM glyald c
constant: false
is: HMDB01051
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
name: D-Glyceraldehyde
is: CHEBI:17378
is: C00577
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_59c562cd_5213_4bd5_95af_ed3a3eb88f88
initial amount: NaN
is: B7Z9T9
is encoded by: hsa:5158
boundary condition: true
has only substance units: false
constant: false
name: PDE6B
is: SBO:0000252
initial concentration: NaN
type: Species

metaM ttdca c
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
type: Species
is: HMDB00806
has only substance units: false
initial amount: NaN
name: myristate
boundary condition: false
initial concentration: 1.0
is: CHEBI:30807
constant: false
is: SBO:0000247

metaM 3dodtricoa m
has only substance units: false
is: HMDB11123
name: 3,6,9-dodecatrienoylcoa
boundary condition: false
constant: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
is: C05279
initial amount: NaN
type: Species
initial concentration: 1.0

metaM 3deccrn c
notes: FORMULA: C17H33NO5 CHARGE: 0
is: HMDB00651
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 3-hydroxydecanoylcarnitine
has only substance units: false
is: SBO:0000247
constant: false
type: Species

metaM hdca l
initial concentration: 1.0
constant: false
boundary condition: false
name: palmitate
is: CHEBI:7896
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
initial amount: NaN
type: Species
is: SBO:0000247

metaM glyclt x
is: HMDB00115
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:29805
name: glycolate

metaM HC01842 c
type: Species
constant: false
name: Phosphodimethylethanolamine
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: SBO:0000247
is: CHEBI:31997
initial amount: NaN

metaR r0423
is: SBO:0000176
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reversible: true
modifier: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
fast: false

metaR MMSAD3m
reactant: MODEL1310110059#
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.27
product: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial

metaR CYTK12
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#
fast: false
type: Reaction
name: cytidylate kinase (dCMP,dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_e06b2257_e6d7_4563_8e8e_42dfe4cd285c
type: Species
name: HAO2
has only substance units: false
is: Q9NYQ3
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51179

metaM gdpfuc c
name: GDP-L-fucose(2-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial amount: NaN
has only substance units: false
is: CHEBI:57984
constant: false
boundary condition: false
type: Species
is: HMDB01095

metaM hcys L c
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: SBO:0000247
constant: false
boundary condition: false
name: L-homocysteine
is: HMDB00742
is: CHEBI:17588
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_d78d3efd_5767_44a5_8e70_69361bcf12f9
name: PRDX2
is encoded by: hsa:7001
is: SBO:0000252
has only substance units: false
is: P32119
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaM HC01405 m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
boundary condition: false
is: CHEBI:28632
type: Species
initial amount: NaN
name: (S)-Hydroxyoctanoyl-CoA

metaR FAOXC184x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaM T antigen g
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C14H24NO10X CHARGE: 0
is: CHEBI:22783
name: T antigen (core 1)
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR DHCR72r
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.21
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
product: MODEL1310110059#
name: 7-dehydrocholesterol reductase
fast: false
reactant: MODEL1310110059#

metaR r0424
reversible: true
modifier: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
product: MODEL1310110059#
reactant: MODEL1310110059#

metaR NADPHtxu
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
name: NADPH transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
product: MODEL1310110059#
type: Reaction
reversible: false

metaM ksi pre34 g
name: keratan sulfate I biosynthesis, precursor 34
is: C00130
has only substance units: false
initial amount: NaN
is: CHEBI:58053
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00175

metaR FAOXC2031836m
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
name: Beta oxidation of fatty acid
reversible: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110059#

metaM xyl D l
is: CHEBI:15936
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: aldehydo-D-xylose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1

metaM ksi deg19 l
name: keratan sulfate I, degradation product 19
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
initial concentration: 1.0
is: CHEBI:16953
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: HMDB00812
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_ae1cdd3b_c9db_40b5_8895_cb1fcbf46db5
type: Species
name: _AI653169_1_c
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AI653169
is: SBO:0000252
initial concentration: NaN

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

metaR CYTK11
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (dCMP,dGTP)
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000269
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR FK
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
reversible: false
modifier: MODEL1310110059#
fast: false
name: Fucokinase
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.52
is described by: ECO:0000000

metaM oagd3 hs g
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 9-O-Acetylated GD3
is: C00329
is: CHEBI:17315
initial amount: NaN
constant: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
has only substance units: false
is: HMDB01514
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_e86664e5_fc4e_4f98_a812_23726564dfad
boundary condition: true
initial concentration: NaN
is: E9PDK1
has only substance units: false
is encoded by: hsa:83697
initial amount: NaN
is: SBO:0000252
constant: false
name: SLC4A9
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_fb7b22a5_655d_4094_a7c9_678c871ff5f7
name: ATP2B1
has only substance units: false
is: SBO:0000252
type: Species
is: P20020
initial concentration: NaN
is encoded by: hsa:490
constant: false
initial amount: NaN
boundary condition: true

metaR GTHOm
type: Reaction
reactant: MODEL1310110059#
name: glutathione oxidoreductase
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is: SBO:0000176
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.8.1.7
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110059#_c3a514c2_8b05_4cbc_910b_dc43b12ce5d0
initial concentration: NaN
is: Q9HAS3
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:64078
initial amount: NaN
type: Species
name: SLC28A3

metaM ttdca e
is: C06424
is: HMDB00806
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:30807
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
name: tetradecanoate (n-C14:0)

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM 3deccrn e
is: SBO:0000247
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C17H33NO5 CHARGE: 0
name: 3-hydroxydecanoylcarnitine
is: HMDB02250

http://identifiers.org/biomodels.db/MODEL1310110059#_a6956b25_f6bd_453b_af7c_3285acff16aa
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: GBA
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2629
boundary condition: true

metaR r0531
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
type: Reaction
is described by: ECO:0000000
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110059#
fast: false
is: SBO:0000176

metaM ile L e
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
name: L-isoleucine
is: SBO:0000247
is: CHEBI:17191
has only substance units: false
type: Species

metaM HC01409 m
is: SBO:0000247
name: Hexanoyl-CoA
is: CHEBI:27540
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
has only substance units: false

metaM cs e deg6 l
boundary condition: false
is: SBO:0000247
is: HMDB00812
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
type: Species
initial concentration: 1.0
is: CHEBI:16953
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
initial amount: NaN

metaM 3dodtricoa x
is: HMDB11123
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: 3,6,9-dodecatrienoylcoa
is: C05279
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_dcb3eed7_d92e_46c6_b30f_084c58727352
is: Q86V21
is: SBO:0000252
name: AACS
boundary condition: true
is encoded by: hsa:65985
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR UMPKn
kinetic law: MODEL1310110059#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is: SBO:0000176
name: UMP kinase, nuclear
type: Reaction
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR CYTK14
is: SBO:0000176
product: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_4c2bba66_246e_41bb_82a0_c6ab642ab384
has only substance units: false
name: IDH3B
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:3420
boundary condition: true
is: SBO:0000252

metaM lnlncacrn m
has only substance units: false
is: HMDB06319
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
name: alpha-linolenyl carnitine
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaM for e
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false
is: HMDB00142
boundary condition: false
is: SBO:0000247
name: formate
constant: false
initial amount: NaN
is: CHEBI:15740
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_49de8a2f_57c8_465b_ac64_84f9a7b952bf
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:5295
has only substance units: false
type: Species
is: P27986
initial concentration: NaN
name: PIK3R1
constant: false

metaR RE2269E
kinetic law: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is version of: http://identifiers.org/ec-code/3.4.21.39
product: MODEL1310110059#
name: RE2269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_e17ebbd1_fa37_4c60_a8a6_f384579cd079
type: Species
has only substance units: false
is: P43353
initial amount: NaN
name: ALDH3B1
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:221

http://identifiers.org/biomodels.db/MODEL1310110059#_d49121ad_26a6_4134_9a41_2addeb7c36b5
name: CLYBL
is encoded by: hsa:171425
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_366e8120_2689_4e27_9daa_838fc47d62e4
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:51227
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

http://identifiers.org/biomodels.db/MODEL1310110059#_98f04f6a_8896_4a70_9907_fadcb7aa25a6
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: STARD3
is: B4DUY1
is: SBO:0000252
is encoded by: hsa:10948

metaR MI34PP
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.66
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
name: inositol-3,4-bisphosphate 4-phosphatase
reversible: false
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD

metaM hdcea e
name: Hexadecenoate (n-C16:1)
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
is: HMDB03229
initial amount: NaN
has only substance units: false
is: CHEBI:32372
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaM HC02175 c
is: CHEBI:27689
boundary condition: false
type: Species
name: caprate
constant: false
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_8fe6cf16_6961_4bde_b33f_b33d36c056b9
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is: P54317
type: Species
is encoded by: hsa:5408
initial amount: NaN
name: PNLIPRP2

metaM oagd3 hs e
is: CHEBI:18421
boundary condition: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
initial amount: NaN
constant: false
is: SBO:0000247
name: 9-O-Acetylated GD3
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB02168

metaR CYTK13
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
name: cytidylate kinase (dCMP,dATP)
product: MODEL1310110059#
modifier: MODEL1310110059#

metaR G6PDH2rer
fast: false
is described by: ECO:0000269
reactant: MODEL1310110059#
is: SBO:0000176
reversible: true
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum

metaM xol7aone m
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
initial amount: NaN
is: HMDB01993
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:17899
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0

metaM fprica c
is: HMDB01439
has only substance units: false
is: CHEBI:58467
constant: false
boundary condition: false
is: C04734
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734

metaM c12dc x
is: C05279
constant: false
is: HMDB11123
initial amount: NaN
notes: FORMULA: C19H34NO6 CHARGE: -1
boundary condition: false
type: Species
name: dodecanedioyl carnitine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM ile L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
initial concentration: 1.0
name: L-isoleucine
is: HMDB00172
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:17191

http://identifiers.org/biomodels.db/MODEL1310110059#_f56d3a5b_7147_4bd0_8c0c_da1ac4304129
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:64064
type: Species
name: OXCT2
constant: false
initial amount: NaN
is: Q9BYC2
boundary condition: true

metaR OCDCAtr
reversible: true
name: fatty acid transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#

metaM mn l
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: beta-1,4-mannose-N-acetylglucosamine
is: HMDB06535
type: Species
has only substance units: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
is: SBO:0000247

metaR r0650
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
product: MODEL1310110059#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.36
modifier: MODEL1310110059#
is described by: ECO:0000000

metaR GLCNACASE3ly
is described by: ECO:0000000
modifier: MODEL1310110059#
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
type: Reaction
reversible: false
reactant: MODEL1310110059#

metaR HSPASEly
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: heparan sulfate proteoglycan protease, lysosome (endosome)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
reversible: false

metaM HC02217 e
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
is: CHEBI:27647
type: Species
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-g2

metaR BTNt4i
type: Reaction
kinetic law: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
name: Biotin uptake (antiport)
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110059#
fast: false

metaM hdca c
initial amount: NaN
name: palmitate
is: CHEBI:7896
is: HMDB00220
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false

metaM nad n
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00902
boundary condition: false
is: CHEBI:57540
type: Species
has only substance units: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
name: NAD(1-)
initial concentration: 1.0

metaM tcynt m
is: HMDB01453
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:18022
initial amount: NaN
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
type: Species
name: thiocyanate

http://identifiers.org/biomodels.db/MODEL1310110059#_5c8e06c9_e8e7_4d56_ba42_08a56f38fa1a
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:R14373
name: _R14373_1_x
type: Species
initial concentration: NaN
initial amount: NaN

metaR TYRTAm
name: tyrosine transaminase, mitochondrial
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.5
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_f52f1725_6135_441a_a7f6_ed7c6dbe8b68
name: ADA
type: Species
constant: false
is encoded by: hsa:100
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P00813
boundary condition: true

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_1fde9646_0278_4ccb_9667_9745b543e410
constant: false
is: P23378
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: GLDC
boundary condition: true
is encoded by: hsa:2731
type: Species
has only substance units: false

metaR r0651
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
fast: false
modifier: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_b768ebe5_89e5_4415_b430_32a1fc1ac094
initial concentration: NaN
is encoded by: hsa:H17063
has only substance units: false
boundary condition: true
initial amount: NaN
name: _H17063_1_m
constant: false
is: SBO:0000252
type: Species

metaR EX 3hexdcrn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaM HC02175 e
initial concentration: 1.0
is: CHEBI:27689
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: caprate
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
has only substance units: false

metaM nad m
initial concentration: 1.0
constant: false
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
initial amount: NaN
is: C00003
is: HMDB00902
has only substance units: false
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540

metaR ALOX52
reactant: MODEL1310110059#
name: Arachidonate 5-lipoxygenase
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.34
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is: SBO:0000176
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_7a69d2a2_a646_44a8_9b19_2e33976f7c16
boundary condition: true
type: Species
is encoded by: hsa:9498
initial concentration: NaN
name: SLC4A8
initial amount: NaN
is: SBO:0000252
is: E7EML0
has only substance units: false
constant: false

metaM zymstnl r
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
constant: false
has only substance units: false
is: CHEBI:16608
is: HMDB06841
name: 5alpha-cholest-8-en-3beta-ol
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_8294a292_5b8e_46a3_b8a3_d204ccee6c0a
type: Species
initial amount: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is: SBO:0000297
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7991
boundary condition: true
constant: false

metaM oagd3 hs c
is: CHEBI:17315
is: C00329
name: 9-O-Acetylated GD3
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
type: Species
is: HMDB01514
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR GLCURter
fast: false
reactant: MODEL1310110059#
reversible: false
name: glucuronate endoplasmic reticular transport
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110059#

metaR C3STDH1Pr
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
is described by: ECO:0000134
modifier: MODEL1310110059#
type: Reaction
fast: false
is: SBO:0000176
name: C-3 sterol dehydrogenase (4-methylzymosterol)
product: MODEL1310110059#
reversible: false

metaM cyan m
is: HMDB02084
name: hydrogen cyanide
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:18407
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_83f22824_fb49_47a0_83b6_86d19a89e87f
is: SBO:0000252
type: Species
initial concentration: NaN
name: ALG6
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:29929
is: Q9Y672
constant: false

metaM gln L c
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: L-glutamine
has only substance units: false
is: HMDB00641
initial amount: NaN
is: CHEBI:18050
constant: false
type: Species

metaM CE5786 e
name: kinetensin
initial amount: NaN
has only substance units: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
constant: false
is: HMDB02710
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27485
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_dd108ad8_8580_4fbe_903c_034e7309b953
initial concentration: NaN
name: B4GALT1:LALBA
type: Species
is encoded by: hsa:3906
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000297
boundary condition: true
has part: P00709

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM prgnlone m
is: HMDB00253
is: SBO:0000247
type: Species
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
constant: false
initial amount: NaN
is: CHEBI:16581
name: pregnenolone
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_e386dbb8_0554_436b_9b32_5e53bad1f00a
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC7A8
is encoded by: hsa:23428
has only substance units: false
type: Species
is: Q9UHI5

http://identifiers.org/biomodels.db/MODEL1310110059#_1846bc13_df19_4f77_b545_d1b9f54ae95b
boundary condition: true
initial concentration: NaN
constant: false
is: Q9ULC5
type: Species
name: ACSL5
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51703

http://identifiers.org/biomodels.db/MODEL1310110059#_af228dbb_7788_46e6_af1d_60e5c80b5f61
has only substance units: false
is encoded by: hsa:279
name: AMY2A
constant: false
boundary condition: true
is: P04746
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_ab1262c7_56a9_4930_bb11_211c091278d4
has only substance units: false
name: IDI1
initial amount: NaN
type: Species
constant: false
is: Q13907
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3422

http://identifiers.org/biomodels.db/MODEL1310110059#_445d9023_eea8_4865_acc7_e1eba6afc121
is encoded by: hsa:51166
is: SBO:0000252
name: AADAT
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: Q8N5Z0
boundary condition: true
initial concentration: NaN

metaR r0317
reversible: true
is: SBO:0000176
fast: false
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110059#

metaR ALCD2yf
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
reversible: false
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
is: SBO:0000176
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110059#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110059#_a6822f06_5fa4_41be_80eb_8e54d44534e6
name: HADH
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q16836
constant: false
is encoded by: hsa:3033

metaM hdca e
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00220
is: C00249
is: CHEBI:0
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1
type: Species
initial amount: NaN
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0

metaR H2O2tp
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
is: SBO:0000185
product: MODEL1310110059#
name: hydrogen peroxide peroxisomal transport via diffusion
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaR RE3624M
reversible: false
product: MODEL1310110059#
is described by: ECO:0000000
name: RE3624
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
modifier: MODEL1310110059#

metaM pail5p hs n
initial concentration: 1.0
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3

metaR HS1ly
is described by: ECO:0000000
modifier: MODEL1310110059#
fast: false
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
reversible: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110059#
type: Reaction

metaR KHte
is: SBO:0000185
product: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
name: KHte
type: Reaction
reversible: true
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_751ef140_bd36_4ac3_bc57_049a3c0d0b7b
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q86SR1
constant: false
type: Species
name: GALNT10
is encoded by: hsa:55568
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_cb63baeb_e48b_4603_b2aa_f28a5f199968
is: P17812
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1503
boundary condition: true
name: CTPS1
has only substance units: false

metaM dd2coa c
boundary condition: false
name: trans-Dodec-2-enoyl-CoA
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110059#_2442b64b_b396_4d91_b906_a61194b256b2
type: Species
is encoded by: hsa:116369
initial amount: NaN
is: Q96RN1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC26A8
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_a5452970_588d_49c2_9319_57daeeb07dd2
is encoded by: hsa:6547
is: Q96QG2
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC8A3

http://identifiers.org/biomodels.db/MODEL1310110059#_cdce7e43_3d89_4328_875e_a9f220f54cd4
is encoded by: hsa:123041
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC24A4
boundary condition: true
type: Species
constant: false
is: Q8NFF2

http://identifiers.org/biomodels.db/MODEL1310110059#_16ab6939_01ae_46e5_af3d_bd8269a1e0f5
name: ACAD10
is: SBO:0000252
boundary condition: true
is encoded by: hsa:80724
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: G3XAJ0
constant: false

metaR r1909
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_cb33db73_0a22_4547_ade9_d844419e7238
initial concentration: NaN
is encoded by: hsa:122622
name: ADSSL1
is: B3KTV4
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r0879
reactant: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
fast: false
kinetic law: MODEL1310110059#
reversible: false
is described by: ECO:0000000

metaM gln L e
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
initial concentration: 1.0
is: HMDB00641
initial amount: NaN
name: L-glutamine
is: CHEBI:18050
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_9cac1a05_fab3_48c9_bbd5_3aa089f6d0b6
is: Q9BY07
initial amount: NaN
is encoded by: hsa:57835
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC4A5
constant: false
has only substance units: false

metaR MMMm
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/5.4.99.2
reversible: true
is: SBO:0000176
name: methylmalonyl-CoA mutase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
fast: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_b12d1834_8133_4c8f_8bc7_f2e4987c1072
constant: false
is: E5KNH5
type: Species
is encoded by: hsa:4723
is: SBO:0000252
name: NDUFV1
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR PROSTGI2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin I2 transport
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000269
product: MODEL1310110059#

metaM odecrn m
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: octadecenoyl carnitine
is: HMDB01114
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: C00412
has only substance units: false
boundary condition: false
is: CHEBI:57394
initial concentration: 1.0

metaM for c
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
is: SBO:0000247
is: HMDB00142
name: Formate
is: C00058
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:15740
has only substance units: false

metaM xyl D e
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:15936
name: aldehydo-D-xylose

metaM nad r
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: HMDB00902
has only substance units: false
is: CHEBI:57540
type: Species
name: NAD(1-)

http://identifiers.org/biomodels.db/MODEL1310110059#_28c8103e_aad8_45cb_9480_bf5230ecb579
type: Species
is encoded by: hsa:6509
is: P43007
initial concentration: NaN
constant: false
boundary condition: true
name: SLC1A4
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_7e626c58_0085_4c6b_8545_306dda7ad76a
has only substance units: false
initial concentration: NaN
name: SLC2A9
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:56606
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_286b373f_29c9_4e4d_9d09_0a4cf3edb299
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: P26439
name: HSD3B2
initial amount: NaN
is encoded by: hsa:3284

metaR FAOXC12C10m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_7df67e6d_a585_4302_a13d_25183c1ddc61
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: GALT
initial concentration: NaN
is encoded by: hsa:2592
is: SBO:0000252
type: Species
is: E7ET32

metaR r0655
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
fast: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
reversible: true

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaR F6Tg
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.68
is: SBO:0000176
name: glycoprotein 6-alpha-L-fucosyltransferase
type: Reaction
reactant: MODEL1310110059#
reversible: false
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000

metaM CE2435 m
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57795
name: trans,cis-deca-2,4-dienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110059#_4b398b5a_4ec0_4b74_8260_683475cd3198
is encoded by: hsa:478
name: ATP1A3:ATP1B1
is encoded by: hsa:481
initial concentration: NaN
boundary condition: true
has part: B7Z2T0
initial amount: NaN
type: Species
constant: false
has part: A3KLL5
is: SBO:0000297
has only substance units: false

metaM dec47dicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
name: 4,7-decadienoylcoa
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_cf85a9ef_ee78_49b3_b637_7d2e3a162a08
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: P51178
is encoded by: hsa:5333
name: PLCD1
has only substance units: false
initial concentration: NaN
type: Species

metaM 3docopencoa m
type: Species
is: http://identifiers.org/pubchem.compound/24892790
constant: false
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
name: 3,7,10,13,16-docosapentenoylcoa
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_83fa6b2a_5afa_4295_ba4e_9ddfc0f0e75a
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GPX1
has only substance units: false
type: Species
is encoded by: hsa:2876
initial concentration: NaN

metaR CO2ter
type: Reaction
product: MODEL1310110059#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is: SBO:0000185
reactant: MODEL1310110059#
name: CO2 endoplasmic reticular transport via diffusion

metaR r1907
fast: false
type: Reaction
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_26c6bac9_0dc1_4c09_981b_538fa576e8a4
constant: false
boundary condition: true
initial concentration: NaN
name: PDE8A
has only substance units: false
is encoded by: hsa:5151
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_be7f6054_1e15_4b3f_85c4_1603798ba90a
is encoded by: hsa:223
initial concentration: NaN
type: Species
is: P49189
name: ALDH9A1
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaM dd2coa x
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: HMDB03712
initial amount: NaN
is: CHEBI:57330
name: trans-Dodec-2-enoyl-CoA
is: SBO:0000247
type: Species
constant: false

metaR OCTDECE1CRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM pail35p hs c
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
type: Species
is: CHEBI:57923
boundary condition: false
has only substance units: false

metaM hpdcacoa m
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB06497
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_e58ca3fc_4cb9_4cfd_8d1b_c452d5819a0e
initial concentration: NaN
type: Species
is encoded by: hsa:5833
initial amount: NaN
has only substance units: false
is: F5H8B1
constant: false
is: SBO:0000252
boundary condition: true
name: PCYT2

http://identifiers.org/biomodels.db/MODEL1310110059#_769c7559_8f7f_489f_868d_6ec2eed14e31
is: Q16678
is encoded by: hsa:1545
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: CYP1B1
is: SBO:0000252

metaM 44mctr r
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01023
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17813

http://identifiers.org/biomodels.db/MODEL1310110059#_cec1576f_5c76_454a_8d9c_3f386082a751
is encoded by: hsa:57134
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q9NR34
name: MAN1C1
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaR EX ivcrn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR FAOXC185C164m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR RE1516M
modifier: MODEL1310110059#
product: MODEL1310110059#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1516
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
kinetic law: MODEL1310110059#

metaR SUCOAS1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (GDP-forming)
modifier: MODEL1310110059#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
reactant: MODEL1310110059#

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110059#
name: galactose-6-sulfate sulfatase, lysosomal
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM xyl D c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
constant: false
initial concentration: 1.0
is: CHEBI:15936
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

metaR UMPK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110059#
is: SBO:0000176
name: UMP kinase (CTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110059#
fast: false
product: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_f339ff8c_64f5_484b_8039_784ab6384c81
boundary condition: true
type: Species
constant: false
name: ATP5A1
initial amount: NaN
initial concentration: NaN
is: P25705
is encoded by: hsa:498
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_c579d9fa_9c50_4b2b_bff6_cf7607371e32
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:8310
boundary condition: true
is: O15254
name: ACOX3
initial amount: NaN
initial concentration: NaN

metaR r0539
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
reactant: MODEL1310110059#
type: Reaction
reversible: true
modifier: MODEL1310110059#
is described by: ECO:0000000
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
fast: false
is: SBO:0000176

metaR FAOXC184m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_21e552a6_552c_4a40_8e01_bfe428d1e1bb
type: Species
name: EHHADH:ACAA1:ACOX1
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has part: Q9NY65
has only substance units: false
is: SBO:0000297
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110059#_85445ea9_0375_4728_8cb6_a31af956be5e
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _AI971036_1_m
is encoded by: hsa:AI971036
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR EX 3octdeccrn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

metaM 13dampp c
is: CHEBI:57484
has only substance units: false
initial amount: NaN
is: HMDB00002
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: trimethylenediaminium

metaR ADPCOACROT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR C226CRNt
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
reversible: false
name: C226 transport into the mitochondria

metaM b2coa m
name: crotonoyl-CoA(4-)
has only substance units: false
is: HMDB02009
initial amount: NaN
type: Species
is: CHEBI:57332
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877

metaR RE1810M
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: true
name: RE1810
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:

metaM ile L m
constant: false
name: L-isoleucine
has only substance units: false
type: Species
boundary condition: false
is: HMDB00172
is: SBO:0000247
is: CHEBI:17191
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN

metaR GHMT2r
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
modifier: MODEL1310110059#
name: glycine hydroxymethyltransferase, reversible
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.1
product: MODEL1310110059#

metaR 4MPTNLte
fast: false
kinetic law: MODEL1310110059#
name: 4-methylpentanal transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:

metaM lneldc c
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
has only substance units: false
is: HMDB06270
initial concentration: 1.0
type: Species
name: linoelaidic acid (all trans C18:2)
initial amount: NaN

metaR SIAASE2ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
name: sialidase, lysosomal
product: MODEL1310110059#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110059#

metaR r1915
reactant: MODEL1310110059#
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM didp n
initial concentration: 1.0
initial amount: NaN
name: dIDP
constant: false
type: Species
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
is: HMDB03536
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_ceed9439_0723_43b8_a307_0e7e68f171f0
boundary condition: true
is encoded by: hsa:957
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: O75356
initial amount: NaN
name: ENTPD5

metaM cholcoar r
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
boundary condition: false
is: HMDB02178
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:58677
type: Species
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)

metaM hs deg7 l
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
name: heparan sulfate, degradation product 7
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
is: HMDB06210

http://identifiers.org/biomodels.db/MODEL1310110059#_eb4b4842_7aff_468f_ae8c_846accb0aabc
is encoded by: hsa:230
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: ALDOC
is: P09972
initial concentration: NaN

metaR GALt2 2
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
is: SBO:0000185
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
name: D-galactose transport via proton symport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110059#_60f9d007_bbf4_4de1_a5d4_d4dd97e96e4b
name: GUCY2F
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: P51841
is encoded by: hsa:2986
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1c354efa_6ebe_437b_8055_003a8e635f61
has only substance units: false
constant: false
is: SBO:0000252
is: P46926
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10007
name: GNPDA1
type: Species

metaM hs deg8 l
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: heparan sulfate, degradation product 8
is: CHEBI:16126
boundary condition: false
constant: false
type: Species

metaR FAOXC9C7m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_4b46eae3_65ea_4e4a_8280_4e01d6d448a8
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: BDH1
initial amount: NaN
constant: false
is encoded by: hsa:622

http://identifiers.org/biomodels.db/MODEL1310110059#_a7830097_115b_4cee_915f_b4c790e0c905
is: SBO:0000252
name: NDUFC2
type: Species
is encoded by: hsa:4718
boundary condition: true
is: Q549M5
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_2abfea9e_6a19_4587_95eb_0cb18f32a718
initial concentration: NaN
boundary condition: true
name: LDHAL6B
type: Species
is: SBO:0000252
is encoded by: hsa:92483
initial amount: NaN
constant: false
is: Q9BYZ2
has only substance units: false

metaR DOPAt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
is: SBO:0000185
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
is described by: ECO:0000269
product: MODEL1310110059#
name: Dopamine reversible transport in via sodium symport (1:2)
fast: false

metaM ser D e
type: Species
name: D-serine
is: HMDB03406
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_8ae1c8b6_243d_4e76_bece_e76af869957a
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: P23743
is encoded by: hsa:1606
is: SBO:0000252
boundary condition: true
name: DGKA
constant: false

metaM tcynt e
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18022
has only substance units: false
is: HMDB01453
constant: false
name: thiocyanate
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

http://identifiers.org/biomodels.db/MODEL1310110059#_10fc6ac3_cc9e_4a66_8a60_6c32fd4f278e
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: NDUFB4
initial concentration: NaN
is encoded by: hsa:4710
is: O95168

metaM nadp m
initial concentration: 1.0
initial amount: NaN
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
is: HMDB00217
is: SBO:0000247
is: CHEBI:58349

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM n2m2nmasn l
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
has only substance units: false
type: Species
is: C04946

metaR VLCS2p
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reversible: false
is described by: ECO:0000304
name: Very-long-chain-fatty-acid-CoA ligase
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176

metaR TETPENT3t
reversible: true
is: SBO:0000185
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
name: fatty acid transport via diffusion
product: MODEL1310110059#
fast: false

metaM lneldc e
name: linoelaidic acid (all trans C18:2)
constant: false
is: HMDB06270
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r1913
type: Reaction
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_027f35dd_88cb_4cc2_97e9_aa8c03d27b9f
boundary condition: true
name: ATP5G1
initial concentration: NaN
constant: false
is: Q6FIH7
initial amount: NaN
is encoded by: hsa:516
is: SBO:0000252
has only substance units: false
type: Species

metaR r0871
reversible: true
name: Diffusion
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_7576cdc2_4498_442f_9c92_da4ea42c8e26
initial amount: NaN
is: SBO:0000297
boundary condition: true
type: Species
constant: false
is encoded by: hsa:55350
name: VNN3:VNN2:VNN1
has only substance units: false
initial concentration: NaN

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM ksi pre33 g
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: C00130
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 33
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_dbcfd1d4_bef5_4ba6_a82a_3be7f782db28
initial concentration: NaN
name: PIGP
is encoded by: hsa:51227
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_5d96c6d4_aeb0_4b7b_a024_a0ae69ada07f
is: SBO:0000252
has only substance units: false
type: Species
name: MCEE
initial amount: NaN
is encoded by: hsa:84693
boundary condition: true
constant: false
is: Q96PE7
initial concentration: NaN

metaR ME1m
is: SBO:0000176
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110059#
name: malic enzyme (NAD), mitochondrial
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.38
modifier: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_4029d5cd_ceff_4770_8ad2_fe8cc9097a16
initial concentration: NaN
is encoded by: hsa:284273
is: SBO:0000252
is: Q4G1C4
initial amount: NaN
constant: false
boundary condition: true
name: ZADH2
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_e2c57713_adb4_4d0c_956e_acf6622fb500
constant: false
name: ATP5H
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: A0PJH2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10476

metaR SACCD3m
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.5.1.8
product: MODEL1310110059#
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial

metaM Tn antigen g
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
name: Tn antigen
is: C04383
notes: FORMULA: C8H14NO5X CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM 3docopencoa x
name: 3,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_777b653b_aa31_4de2_b40d_b7c2e351fefb
is encoded by: hsa:53354
is: Q8TE04
constant: false
initial concentration: NaN
has only substance units: false
name: PANK1
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_72b70d9d_bf86_4f6a_844d_ae368718ed6d
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P40879
has only substance units: false
is encoded by: hsa:1811
constant: false
name: SLC26A3
type: Species

metaR r0870
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
fast: false
product: MODEL1310110059#
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/2.7.7.72
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.4
is version of: http://identifiers.org/ec-code/3.6.4.13

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR VLCS2r
is: SBO:0000176
product: MODEL1310110059#
name: Very-long-chain-fatty-acid-CoA ligase
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reactant: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000304
modifier: MODEL1310110059#
reversible: false

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaM tcynt c
boundary condition: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
is: HMDB01453
name: thiocyanate
initial amount: NaN
is: SBO:0000247
is: CHEBI:18022
initial concentration: 1.0
type: Species
has only substance units: false

metaM ser D c
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: HMDB03406
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: D-serine
initial concentration: 1.0
is: CHEBI:16523
is: SBO:0000247

metaR LCADi D
is described by: ECO:0000304
product: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
name: lactaldehyde dehydrogenase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_5a84fd33_6808_4814_811a_2ad7605bd36f
initial concentration: NaN
constant: false
is: P10696
boundary condition: true
is encoded by: hsa:251
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: ALPPL2

metaM hdcea c
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
initial concentration: 1.0
constant: false
name: Hexadecenoate (n-C16:1)
is: CHEBI:32372
is: HMDB03229
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_a090882d_021a_4d86_9109_034bb13d6149
initial amount: NaN
is: Q5JPH6
constant: false
is: SBO:0000252
is encoded by: hsa:124454
type: Species
initial concentration: NaN
boundary condition: true
name: EARS2
has only substance units: false

metaR RE0453N
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
name: RE0453
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reversible: true

metaM sbcoa c
is: C02838
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: suberylcoa
type: Species
is: HMDB00791
initial amount: NaN

metaM fadh2 c
has only substance units: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
is: CHEBI:58307
is: SBO:0000247
name: FADH2(2-)
constant: false
is: HMDB01197
initial amount: NaN
type: Species
boundary condition: false

metaR PAIL HStn
reversible: true
is: SBO:0000185
name: phosphatidylinositol nuclear transport (diffusion)
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaM gln L m
is: HMDB00641
name: L-glutamine
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
type: Species
is: CHEBI:18050

http://identifiers.org/biomodels.db/MODEL1310110059#_7a9ac893_e40e_46af_93f3_2d5e40051aad
is encoded by: hsa:4728
is: O00217
name: NDUFS8
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR STRDNCt
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
name: fatty acid transport via diffusion
is: SBO:0000185
product: MODEL1310110059#

metaR r0311
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
type: Reaction
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is: SBO:0000176

metaR PE HSter
is: SBO:0000185
type: Reaction
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
reactant: MODEL1310110059#
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_576fa844_a391_4ebe_bc36_2ed230adeeef
constant: false
boundary condition: true
is: A8MYF6
type: Species
name: MSMO1
is encoded by: hsa:6307
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_5d25050b_db4e_4a3f_ada9_8bb604151f80
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:6578
has only substance units: false
name: SLCO2A1
is: Q92959
initial amount: NaN
is: SBO:0000252

metaM fadh2 r
is: CHEBI:58307
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
initial concentration: 1.0
name: FADH2(2-)
boundary condition: false
is: HMDB01197
has only substance units: false
constant: false
type: Species

metaM nadp r
is: CHEBI:58349
is: HMDB00217
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false

metaM ksi pre5 g
has only substance units: false
is: CHEBI:28067
notes: FORMULA: C101H164N7O75SX CHARGE: -2
type: Species
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 5
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM pe hs m
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
constant: false
type: Species
name: phosphatidylethanolamine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16038

http://identifiers.org/biomodels.db/MODEL1310110059#_8ce40796_bb52_4b3d_aa9e_9e9f024f053f
type: Species
is: P56181
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:4731
is: SBO:0000252
name: NDUFV3

metaR NDPK6n
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176

metaM 3bcrn e
is: HMDB04047
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H21NO5 CHARGE: 0
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: 3-hydroxy butyryl carnitine
is: C14143
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_eeab26be_a32d_4bfa_907a_3915ba110680
is: B1AK53
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:83715
name: ESPN
is: SBO:0000252
type: Species

metaR DPMVDx
fast: false
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is described by: ECO:0000134
reversible: false
is: SBO:0000176
name: diphosphomevalonate decarboxylase
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.1.1.33

metaM 5aizc c
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
constant: false
is: SBO:0000247
is: HMDB06273
is: C04751
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
has only substance units: false
initial concentration: 1.0
is: CHEBI:58564

metaM ksi pre10 g
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
is: C00130
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
is: HMDB00175
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 10
initial concentration: 1.0

metaR KSItly
name: keratan sulfate I transport, extracellular to lysosome
is: SBO:0000185
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110059#
fast: false

metaR CHAT
name: Choline O-acetyltransferase
is described by: ECO:0000269
reversible: true
product: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is: SBO:0000176
reactant: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6
kinetic law: MODEL1310110059#

metaR NDPK6m
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110059#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
fast: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
is: SBO:0000176
modifier: MODEL1310110059#

metaR r0119
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is described by: ECO:0000000

metaM Tn antigen l
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Tn antigen
constant: false
is: C04383

metaR DHCR71r
name: 7-dehydrocholesterol reductase
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.1.21
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000134
fast: false
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ

metaR ITCOAL1m
kinetic law: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000304
fast: false
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (GDP-forming), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110059#_996ac085_c838_45a5_812d_7a6260886efd
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: _AI291895_1_c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI291895
constant: false

metaM 4mop c
name: 4-methyl-2-oxopentanoate
is: HMDB00695
is: CHEBI:17865
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false

metaR r1291
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false

metaR r0426
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.5.1.34
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
product: MODEL1310110059#
reversible: true
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
type: Reaction
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR PRGNLONEtm
name: pregnenolone intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
reversible: true
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
is: SBO:0000185

metaR BCDO
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.36
name: beta-Carotene dioxygenase
notes: GENE_ASSOCIATION: (53630.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES:IT
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#

metaM hpdcacoa c
is: SBO:0000247
is: HMDB06497
type: Species
boundary condition: false
constant: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM n2m2nmn l
constant: false
is: CHEBI:16680
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C50H84N4O36 CHARGE: 0
is: SBO:0000247
type: Species
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
initial amount: NaN
is: HMDB00939

metaM hdca r
has only substance units: false
constant: false
name: Hexadecanoate (n-C16:0)
is: C00249
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
is: HMDB00220
initial amount: NaN
type: Species
is: CHEBI:7896
is: SBO:0000247

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_1ab01019_8989_4a6e_af2b_48585a508883
is encoded by: hsa:1109
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P17516
constant: false
has only substance units: false
name: AKR1C4

metaR H6ET3er
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
product: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.8.1
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
fast: false

metaM dd2coa m
type: Species
has only substance units: false
constant: false
is: CHEBI:57330
is: HMDB03712
name: trans-dodec-2-enoyl-CoA(4-)
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR NDP8ex
type: Reaction
name: nucleoside-diphosphatase (UTP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR 4MPTNLtm
is described by: ECO:0000000
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
reactant: MODEL1310110059#
fast: false
name: 4-methylpentanal transport (mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_393c0fb1_dfa0_4d52_86f4_4bf89003f124
is encoded by: hsa:4700
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: NDUFA6
boundary condition: true
type: Species
is: P56556
has only substance units: false

metaR 3SALATAim
modifier: MODEL1310110059#
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110059#
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain

http://identifiers.org/biomodels.db/MODEL1310110059#_e5569fdb_a140_48df_92e1_2d3adb433a0f
name: SORD
is encoded by: hsa:6652
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q00796
is: SBO:0000252
initial amount: NaN

metaM 3bcrn c
initial concentration: 1.0
is: C14143
name: 3-hydroxy butyryl carnitine
constant: false
initial amount: NaN
boundary condition: false
is: HMDB04047
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C11H21NO5 CHARGE: 0

metaR TMNDNCCPT2
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
name: carnitine transferase
is: SBO:0000176
reversible: false
product: MODEL1310110059#

metaM pydam c
is: SBO:0000247
name: Pyridoxamine
is: C00534
constant: false
is: HMDB01431
boundary condition: false
initial amount: NaN
is: CHEBI:57761
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
initial concentration: 1.0
type: Species
has only substance units: false

metaR FATP5t
reactant: MODEL1310110059#
name: fatty acid electroneutral transport
type: Reaction
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
is described by: ECO:0000269
product: MODEL1310110059#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.7

metaM glyald m
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
name: D-glyceraldehyde
is: CHEBI:17378
initial amount: NaN
is: HMDB01051
has only substance units: false
boundary condition: false
constant: false

metaR r0202
fast: false
reversible: true
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:

metaM gum e
has only substance units: false
constant: false
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: gums
type: Species
is: HMDB00725

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR 34HPPte
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: Transport of 3-(4-hydroxyphenyl)pyruvate

metaM mev R c
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00227
constant: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
name: (R)-mevalonate
is: CHEBI:36464
initial amount: NaN

metaM Ssq23epx r
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: CHEBI:15441
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01188
boundary condition: false
name: (S)-2,3-epoxysqualene
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_909da39b_a55b_44f9_909a_92f87c6e0cb3
is: P22680
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1581
type: Species
has only substance units: false
name: CYP7A1
constant: false
boundary condition: true

metaR MI3PP
is version of: http://identifiers.org/ec-code/3.1.3.25
kinetic law: MODEL1310110059#
type: Reaction
name: myo-inositol 3-phosphatase
reversible: false
product: MODEL1310110059#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
modifier: MODEL1310110059#
is described by: ECO:0000269
reactant: MODEL1310110059#

metaR TMNDNCCPT1
product: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: carnitine O-palmitoyltransferase
reversible: false

metaM HC00319 c
is: CHEBI:30794
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
name: Malonate
is: SBO:0000247

metaR RE2666C
type: Reaction
is described by: ECO:0000000
reversible: false
name: RE2666
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_0e9a122d_12b5_4586_a95a_79896969d127
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:54898
name: ELOVL2
has only substance units: false
initial concentration: NaN
constant: false
is: Q9NXB9
type: Species

metaR TRDRm
product: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.9
reversible: false
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
type: Reaction
name: thioredoxin reductase (NADPH)
fast: false
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
reactant: MODEL1310110059#

metaR UGLT
reactant: MODEL1310110059#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.12
type: Reaction

metaM maltpt e
initial amount: NaN
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: HMDB01296
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141
is: C02052
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: maltopentaose
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_402fd99e_6c16_4142_a2d0_2486b038e8c4
initial concentration: NaN
is: P00491
name: PNP
constant: false
boundary condition: true
is encoded by: hsa:4860
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaM leuktrF4 e
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
is: HMDB06465
boundary condition: false
initial amount: NaN
is: CHEBI:27491
name: leukotriene F4

metaR C12DCACOT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaR EX doco13ac
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_aaa3dc51_3f54_41aa_808c_9e0d7302f265
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: TXNRD2
is encoded by: hsa:10587

metaM retfa c
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial concentration: 1.0
name: fatty acid retinol
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:50211
is: SBO:0000247
has only substance units: false
is: HMDB00305

http://identifiers.org/biomodels.db/MODEL1310110059#_b85f2f1a_f366_4d36_84da_d2ebdfd0b850
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:130367
initial concentration: NaN
is: Q8IWX5
has only substance units: false
name: SGPP2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_483d7f19_be07_46e9_b278_37cebc3f71a1
is: SBO:0000252
boundary condition: true
name: ALDH4A1
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: P30038
is encoded by: hsa:8659
has only substance units: false

metaR NACHEX16ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reactant: MODEL1310110059#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_78c534bc_30de_46ae_ad49_eb802163f423
initial amount: NaN
has only substance units: false
is: P31350
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: RRM2
constant: false
is encoded by: hsa:6241

metaM for r
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
is: HMDB00142
is: SBO:0000247
name: Formate
is: CHEBI:15740
initial concentration: 1.0
is: C00058
initial amount: NaN

metaR MALT
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2595.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:12370436,PMID:7018580 NOTES:IF
reversible: false
type: Reaction
name: alpha-glucosidase
fast: false
is described by: ECO:0000269
reactant: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.20
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_45782c07_efdb_43ec_a1ce_7c72cc1e57b5
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC23A1
constant: false
is encoded by: hsa:9963
initial amount: NaN
boundary condition: true

metaR BHBtm
reversible: true
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
fast: false
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
product: MODEL1310110059#

metaR RE1527M
product: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110059#
reversible: true
is: SBO:0000176
name: RE1527
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
kinetic law: MODEL1310110059#
type: Reaction

metaM fadh2 m
is: C01352
boundary condition: false
initial concentration: 1.0
is: CHEBI:58307
name: Flavin adenine dinucleotide reduced
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
constant: false
has only substance units: false

metaR HISCAT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM pe hs r
initial amount: NaN
has only substance units: false
is: CHEBI:16038
name: phosphatidylethanolamine
type: Species
constant: false
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247

metaR r2067
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#

metaM cs a deg3 l
is: SBO:0000247
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: HMDB00127
type: Species
boundary condition: false
is: CHEBI:15748
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
initial concentration: 1.0
has only substance units: false
constant: false

metaM dctp c
constant: false
is: C00458
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998
is: CHEBI:16311
initial concentration: 1.0
type: Species
name: dCTP
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_6dd76923_1c6e_4d44_9e5e_9ffc25f2385c
initial amount: NaN
is: SBO:0000252
name: NDUFS5
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4725
boundary condition: true
is: Q6IBA0

metaM nadp x
has only substance units: false
is: C00006
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
initial concentration: 1.0
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_41b6f431_674c_4239_9bfb_79bebbab5772
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: ALDH3B2
initial amount: NaN
is encoded by: hsa:222
is: P48448

http://identifiers.org/biomodels.db/MODEL1310110059#_588b3c3a_d353_4144_a187_fe0eb0dd5531
type: Species
initial concentration: NaN
name: PDE9A
boundary condition: true
constant: false
is encoded by: hsa:5152
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_505d7563_bea8_4ba8_8d7d_672a66814273
name: _AA526438_1_c
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AA526438
initial concentration: NaN
type: Species
boundary condition: true

metaR RE1531M
reactant: MODEL1310110059#
name: RE1531
is: SBO:0000176
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
reversible: true

metaR SO4t4 2
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110059#
reversible: true
fast: false
type: Reaction
name: sulfate transport via sodium symport
kinetic law: MODEL1310110059#

metaM leuktrF4 c
boundary condition: false
is: HMDB06465
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:27491
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
initial amount: NaN
name: leukotriene F4
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_a39faad3_89fd_4337_b951_5e00972aa364
initial amount: NaN
type: Species
constant: false
name: PANK2
has only substance units: false
initial concentration: NaN
is: Q9BZ23
is encoded by: hsa:80025
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_f29eb82d_7765_4bc8_aae4_0473faf8134f
constant: false
has only substance units: false
boundary condition: true
is: Q96H96
is encoded by: hsa:27235
initial amount: NaN
name: COQ2
type: Species
is: SBO:0000252
initial concentration: NaN

metaR GALASE6ly
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110059#
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal

metaR r1292
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110059#
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_31884cdc_9b1f_4781_8b78_862d77d9fdfc
is: SBO:0000252
boundary condition: true
constant: false
name: PRDX1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5052
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_6677eafe_55ef_4750_b593_389bf964ba6c
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is: H7C5B8
is encoded by: hsa:4708
initial amount: NaN
type: Species
initial concentration: NaN
name: NDUFB2

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_c2097691_acf4_4aa6_9c74_ad7409fd2109
initial concentration: NaN
is encoded by: hsa:27010
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: F5GZG6
type: Species
name: TPK1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_5abd6c70_a47d_4a68_bdd9_791fc1a2dd38
boundary condition: true
is encoded by: hsa:286016
is: SBO:0000252
constant: false
name: TPI1P2
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR ASCBt4
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is described by: ECO:0000269
name: L-ascorbate transport via proton symport
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#

metaM c12dccoa c
has only substance units: false
type: Species
name: dodecanedioylcoa
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: HMDB00623
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR MCCCrm
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.4.1.4
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
name: methylcrotonoyl-CoA carboxylase, mitochondrial
type: Reaction

metaR DM dctp m
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dCTP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_b2253144_80ed_48e6_b629_8277f17e4fb2
initial amount: NaN
is encoded by: hsa:2983
is encoded by: hsa:2977
has part: P33402
boundary condition: true
is: SBO:0000297
initial concentration: NaN
has only substance units: false
has part: Q02153
constant: false
type: Species
name: GUCY1A2:GUCY1B3

http://identifiers.org/biomodels.db/MODEL1310110059#_b5b911cc_3ff6_478b_b8bc_c0c09e62f30e
has part: Q6IB54
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
has only substance units: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:522
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_86447c97_a8a1_4722_a860_f962e46033a2
boundary condition: true
constant: false
is: Q9UKM7
is: SBO:0000252
type: Species
initial concentration: NaN
name: MAN1B1
has only substance units: false
is encoded by: hsa:11253
initial amount: NaN

metaR MTHFCm
type: Reaction
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/6.3.4.3
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
fast: false
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#

metaM ksi pre4 g
type: Species
is: C00130
constant: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 4
is: HMDB00175
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C101H165N7O72X CHARGE: -1
initial concentration: 1.0

metaM glyclt c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: HMDB00115
boundary condition: false
type: Species
name: glycolate
is: SBO:0000247
initial amount: NaN
is: CHEBI:29805
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_8c57de32_51dd_4d2d_b1d3_a0118092d8a9
has only substance units: false
is: SBO:0000297
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: NME1:NME2
is encoded by: hsa:4830

metaM 4mop e
boundary condition: false
is: CHEBI:17865
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
constant: false
is: HMDB00695
initial amount: NaN
name: 4-methyl-2-oxopentanoate

metaR LNLNCAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: fatty acid transport via diffusion
fast: false
reversible: true
reactant: MODEL1310110059#

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM tchola x
boundary condition: false
initial amount: NaN
name: taurocholate
is: SBO:0000247
is: CHEBI:36257
initial concentration: 1.0
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
constant: false
has only substance units: false

metaM hs deg24 l
is: SBO:0000247
notes: FORMULA: C31H50NO26 CHARGE: -1
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16126
boundary condition: false
initial concentration: 1.0
name: GlcNAc-GlcA-(Gal)2-Xyl
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_194dd0f5_493d_4fae_a28f_9abed43002a2
has only substance units: false
has part: P48201
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:518
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_b9c77a94_21d6_444f_8194_283994c59bcc
is: Q9Y6T7
boundary condition: true
is encoded by: hsa:1607
constant: false
type: Species
name: DGKB
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR VITD3t2
type: Reaction
fast: false
is described by: ECO:0000000
name: Vitamin D3 uptake
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
reactant: MODEL1310110059#
reversible: false

metaM dcacoa c
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB06404
initial amount: NaN
type: Species
initial concentration: 1.0
name: Decanoyl-CoA (n-C10:0CoA)
is: C05274
has only substance units: false
is: CHEBI:61430

http://identifiers.org/biomodels.db/MODEL1310110059#_065920d6_64ea_4c5e_905e_cc18426000cc
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is: Q9BT22
is encoded by: hsa:56052
is: SBO:0000252
name: ALG1

metaM 2obut m
is: SBO:0000247
is: CHEBI:16763
type: Species
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00005
name: 2-oxobutanoate

metaR FAOXC183806m
is: SBO:0000176
product: MODEL1310110059#
name: Beta oxidation of fatty acid
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction

metaR PIt8
product: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is described by: ECO:0000006
name: phosphate transport in/out via Na+ symporter
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000185
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR FAOXC141C121x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR 3HCO3 NAt
reactant: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
name: 3HCO3_NAt

metaR r0752
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110059#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
product: MODEL1310110059#

metaM eitetcoa m
constant: false
name: 5,8,11,14-eicosatetraenoylcoa
has only substance units: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM HC00319 m
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:30794
name: Malonate
type: Species
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_1ba07c9a_a15a_4361_9e22_d51d067431be
is: O14561
name: NDUFAB1
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4706
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_8ce21230_7f61_48fa_a644_fb5d163bab27
type: Species
name: ELOVL4
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6785
constant: false
initial concentration: NaN
is: Q9GZR5
boundary condition: true
initial amount: NaN

metaR PFK26
modifier: MODEL1310110059#
fast: false
name: 6-phosphofructo-2-kinase
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.1.105
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF

http://identifiers.org/biomodels.db/MODEL1310110059#_a77be80c_b204_4e44_bc99_3af91cad43a8
type: Species
is: Q6LEN5
constant: false
name: CHAT
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1103
is: SBO:0000252

metaR C60CPT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaR FADtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
name: FAD transporter, peroxisomal
reactant: MODEL1310110059#
is: SBO:0000185
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_e325c4f0_8f7b_4af5_b3b6_4f73a07583ae
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:10201
is: O75414
name: NME6
initial amount: NaN
type: Species
is: SBO:0000252

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_6252ae6c_362a_4459_901e_b34c4427d352
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is: Q96CA6
is encoded by: hsa:30
initial amount: NaN
initial concentration: NaN
name: ACAA1

metaR NACASPAH
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.15
fast: false
name: N-Acetyl-L-aspartate amidohydrolase
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
modifier: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176

metaM malthx e
has only substance units: false
name: Maltohexaose
initial amount: NaN
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: http://identifiers.org/pubchem.compound/5041
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110059#_cdb46402_49be_4bb0_b5b7_849ac9e62767
is: Q969K7
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:113452
is: SBO:0000252
name: TMEM54

http://identifiers.org/biomodels.db/MODEL1310110059#_25eb59cb_d2fe_41d7_a103_29a3e9107b57
is: P37287
type: Species
initial concentration: NaN
is: SBO:0000252
name: PIGA
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:5277

http://identifiers.org/biomodels.db/MODEL1310110059#_ca0b0124_29c5_4a6b_9acd_bfcb6a893e51
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:27068
is: Q9H2U2
initial concentration: NaN
name: PPA2
constant: false
is: SBO:0000252

metaR M7MASNBterg
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000

metaR r0750
modifier: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
is described by: ECO:0000000
type: Reaction
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is: SBO:0000176
fast: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_06f7272e_ae4a_4a93_ae4e_398319fd99d3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q02338
boundary condition: true
constant: false
name: BDH1
type: Species
is encoded by: hsa:622

http://identifiers.org/biomodels.db/MODEL1310110059#_299e0250_3e80_4bce_b5a2_60390bf24e5a
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5152
name: PDE9A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_7ed9eb4a_b1b7_4c3a_8a2b_60a193e0e989
is encoded by: hsa:221
has only substance units: false
constant: false
boundary condition: true
type: Species
is: P43353
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ALDH3B1

metaM HC01435 m
constant: false
notes: FORMULA: C16H21N4O10P2S CHARGE: -3 INCHI: InChI=1S/C16H24N4O10P2S/c1-9-13(5-6-29-32(27,28)30-31(24,25)26)33-16(12(21)3-4-14(22)23)20(9)8-11-7-18-10(2)19-15(11)17/h7,12,21H,3-6,8H2,1-2H3,(H5-,17,18,19,22,23,24,25,26,27,28)/p+1 EHMN_ABBREVIATION: C05381
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: 3-Carboxy-1-hydroxypropyl-ThPP
is: CHEBI:1463
initial amount: NaN
is: SBO:0000247

metaR FADH2ETC
reactant: MODEL1310110059#
reversible: false
is described by: ECO:0000134
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110059#
name: Complex II reaction for respiratory chain

http://identifiers.org/biomodels.db/MODEL1310110059#_8f4d30c6_3499_4792_90b9_91752078fe42
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q86YN1
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:57171
name: DOLPP1

metaR PEROXx
product: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
name: peroxisomal lumped long chain fatty acid oxidation
kinetic law: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110059#_53e61c1b_b7eb_4c0d_82fa_5cd8cee94294
name: COX6B2
initial amount: NaN
type: Species
is encoded by: hsa:125965
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q6YFQ2
constant: false
initial concentration: NaN

metaR S6TASE16ly
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110059#
reversible: true
is: SBO:0000176
fast: false

metaR UDPG4E
modifier: MODEL1310110059#
fast: false
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: UDPglucose 4-epimerase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.2
reactant: MODEL1310110059#
reversible: true

metaM succ x
constant: false
is: CHEBI:30031
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: C00042
name: Succinate
is: SBO:0000247
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species

metaR KYNATESYN
is: SBO:0000176
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
reversible: false

metaR RE0830C
reversible: true
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110059#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: RE0830

metaM pac c
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: CHEBI:18401
is: HMDB00209
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
name: phenylacetate
initial amount: NaN
type: Species
initial concentration: 1.0

metaR EX caro LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

metaR AG13T6g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaM s2l2n2m2masn l
notes: FORMULA: C84H135N6O61X CHARGE: -2
boundary condition: false
is: SBO:0000247
is: CHEBI:18287
is: HMDB00174
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: de-Fuc form of PA6
initial concentration: 1.0

metaR r0973
fast: false
product: MODEL1310110059#
name: Facilitated diffusion
type: Reaction
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_d6b98d60_3ecc_4068_8cbf_00a3b3c5b817
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AA526438
has only substance units: false
name: _AA526438_1_m
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_588e4aaf_e3a9_4c28_be80_d73d89c7ea86
is: SBO:0000297
has part: P14415
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: ATP1A3:ATP1B2
boundary condition: true
constant: false
is encoded by: hsa:482

http://identifiers.org/biomodels.db/MODEL1310110059#_3d26af15_1d63_4430_ad7e_6439619ce0b0
name: _BE966236_1_c
constant: false
is encoded by: hsa:BE966236
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_d87d0c69_1d60_44b1_94bb_248b8be83d02
name: HCST
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:10870
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9UBK5

http://identifiers.org/biomodels.db/MODEL1310110059#_233e9e34_3747_4770_a714_a28d9d4d6c7d
is encoded by: hsa:6567
has only substance units: false
boundary condition: true
name: SLC16A2
is: P36021
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM prostge1 e
is: HMDB01442
name: prostaglandin E1(1-)
is: CHEBI:57397
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
constant: false
type: Species

metaR S6T14g
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110059#_e1a62bb8_7b80_42fc_b1b2_b2047ff53fc6
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4731
is: P56181
initial concentration: NaN
constant: false
name: NDUFV3
initial amount: NaN

metaR NOt
reversible: true
name: NO transport (diffusion)
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
reactant: MODEL1310110059#
product: MODEL1310110059#

metaR r0437
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110059#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: true
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_8ccb8b54_644d_485e_be67_dd9e80d2f01e
is: Q59FD4
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:3098
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: HK1

metaM itp c
is: HMDB00189
name: ITP(3-)
is: CHEBI:57614
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

http://identifiers.org/biomodels.db/MODEL1310110059#_c100a370_0ab8_47bf_a12a_5fb79db10dc0
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9Y5L3
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:954
name: ENTPD2
boundary condition: true

metaM lnlc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30245
constant: false
name: linoleate
is: SBO:0000247
has only substance units: false
is: HMDB00673
type: Species
boundary condition: false

metaR r0974
name: Active transport
type: Reaction
kinetic law: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_af562020_0531_443c_94ad_ad575cb3c09d
is encoded by: hsa:6391
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q99643
initial concentration: NaN
constant: false
name: SDHC
is: SBO:0000252

metaM HC01407 m
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
has only substance units: false
name: (S)-Hydroxyhexanoyl-CoA
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:28276
is: SBO:0000247
initial amount: NaN

metaR SERDGLNexR
fast: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
name: D-Serine/Glutamine reversible exchange
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110059#

metaM ksi deg27 l
initial concentration: 1.0
constant: false
is: CHEBI:12936
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 27
initial amount: NaN
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
has only substance units: false

metaR IDOURte
type: Reaction
is described by: ECO:0000134
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
name: L-iduronate transport, extracellular
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

metaM acmana c
name: N-acetyl-D-mannosamine
is: HMDB01129
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
has only substance units: false
constant: false
is: CHEBI:17122

http://identifiers.org/biomodels.db/MODEL1310110059#_37492766_0da2_4f8f_86ec_a30dcbcfc5d0
is encoded by: hsa:515
has only substance units: false
type: Species
name: ATP5F1
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM dlnlcgcoa c
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
is: CHEBI:27979
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_2de95cb7_8706_443b_a568_8dd3e6dbbfed
is: SBO:0000252
has only substance units: false
name: PAPSS1
initial amount: NaN
is: O43252
is encoded by: hsa:9061
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaM CE0713 m
boundary condition: false
is: SBO:0000247
is: CHEBI:30623
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
has only substance units: false
name: 3-oxolinoleoyl-CoA
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB02329

http://identifiers.org/biomodels.db/MODEL1310110059#_1d121c8f_5166_45ce_b3a5_7e8faaf18e0f
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: Q1EHB4
is: SBO:0000252
type: Species
has only substance units: false
name: SLC5A12
is encoded by: hsa:159963

metaR r0434
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
reversible: true
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaR EX c5dc
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR MM5cg
product: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
type: Reaction
modifier: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110059#
is: SBO:0000176

metaR NACHEX20ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_2d7a36e1_3689_4118_adea_f0155153c1fe
is encoded by: hsa:H45672
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: _H45672_1_m
has only substance units: false

metaR GTHPm
kinetic law: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
modifier: MODEL1310110059#
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.15
fast: false

metaR CITL
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
modifier: MODEL1310110059#
name: Citrate lyase
reactant: MODEL1310110059#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_7c548cdc_2f61_45bf_b7d1_8ed20595e7e6
is: E7EQF2
type: Species
is encoded by: hsa:54677
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: CROT

metaM fuc L c
is: SBO:0000247
name: L-fucose
has only substance units: false
type: Species
boundary condition: false
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
initial amount: NaN
is: CHEBI:18287
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_48aad6f9_18f5_4ab1_a088_5554544718a5
initial amount: NaN
constant: false
name: AKR1A1
is encoded by: hsa:10327
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM mev R x
is: SBO:0000247
initial concentration: 1.0
is: HMDB00227
boundary condition: false
name: (R)-mevalonate
constant: false
has only substance units: false
type: Species
is: CHEBI:36464
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial amount: NaN

metaR GALASE18ly
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
reversible: false
type: Reaction

metaM itp e
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57614
initial concentration: 1.0
type: Species
name: ITP(3-)
is: HMDB00189

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM hestratriol e
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
name: 4,17 dihydroxy estradiol
is: HMDB05896
boundary condition: false

metaR ASNtm
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
fast: false
is: SBO:0000185
name: L-asparagine transport, mitochondrial
type: Reaction
reactant: MODEL1310110059#
reversible: false

metaM 2octdectecoa m
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: 2,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

metaR r0545
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
product: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110059#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
type: Reaction
fast: false
is: SBO:0000176

metaR SUCCACT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaM dctp m
name: dCTP
is: C00458
initial amount: NaN
is: CHEBI:16311
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_2c56a4d6_53da_4caa_b9cc_f358dc99eb77
initial concentration: NaN
is encoded by: hsa:6184
constant: false
is: P04843
has only substance units: false
name: RPN1
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_8a6cf500_00cd_4a75_896a_ab85739a4ad6
type: Species
is: SBO:0000297
name: NME1:NME2
constant: false
initial concentration: NaN
is encoded by: hsa:4831
has part: P22392
is encoded by: hsa:4830
has part: P15531
initial amount: NaN
has only substance units: false
boundary condition: true

metaM nrvnccoa x
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
type: Species
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
is: SBO:0000247
initial amount: NaN
name: nervonyl coenzyme A
is: C16532

metaR AMETr
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
name: S-Adenosyl-L-methionine intracellular diffusion
is described by: ECO:0000000
reactant: MODEL1310110059#
type: Reaction

metaR FAOXC14C14OHm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_0a641118_7ef4_4374_a007_5a99536ac0d0
initial concentration: NaN
is encoded by: hsa:6487
type: Species
is: SBO:0000252
name: ST3GAL3
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: Q11203

http://identifiers.org/biomodels.db/MODEL1310110059#_11b2eb66_4733_4805_beb8_f4dee77d063d
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: B4E1R2
name: CTH
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1491
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_8c3f835f_c5a4_4df7_b60f_75bccf67f8f1
name: PIK3CB
type: Species
is: SBO:0000252
is: B4DER4
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:5291

metaM dlnlcgcoa r
is: C03595
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27979
has only substance units: false
type: Species
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
boundary condition: false
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110059#_4f03c7c5_a629_49e4_acb1_4c3277deb984
initial concentration: NaN
constant: false
is: Q92685
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: ALG3
is encoded by: hsa:10195
has only substance units: false

metaR HESTRATRIOLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
is described by: ECO:0000000
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
type: Reaction
fast: false
name: hydroxylated estrogen derivative transport
reversible: true
kinetic law: MODEL1310110059#

metaM hestratriol c
is: HMDB05896
constant: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
name: 4,17 dihydroxy estradiol
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM adrncoa x
type: Species
has only substance units: false
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205480
initial concentration: 1.0
initial amount: NaN
is: C16170
name: adrenyl coenzyme A
is: SBO:0000247
boundary condition: false

metaR GLYOX
kinetic law: MODEL1310110059#
name: hydroxyacylglutathione hydrolase
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.2.6
type: Reaction
modifier: MODEL1310110059#

metaM g2m8masn r
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
is: C05874
is: SBO:0000247
notes: FORMULA: C82H137N2O65X CHARGE: 0

metaR r0130
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_66f9464f_2cde_4098_b4a1_0355dd5f0753
is: Q99643
constant: false
initial amount: NaN
boundary condition: true
name: SDHC
is: SBO:0000252
is encoded by: hsa:6391
type: Species
initial concentration: NaN
has only substance units: false

metaM HC02216 c
is: CHEBI:28922
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f2beta
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_8fc07ff0_97d1_4e42_9794_f0b77da0b283
initial concentration: NaN
type: Species
is encoded by: hsa:1503
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CTPS1
initial amount: NaN
constant: false
is: P17812

http://identifiers.org/biomodels.db/MODEL1310110059#_a56ea8fc_10ae_405a_9a1f_bc68a8f121ed
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2974
name: GUCY1B2
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_87367ac2_ec3b_49da_a360_f276e7a2bec3
type: Species
is: Q01959
has only substance units: false
boundary condition: true
constant: false
name: SLC6A3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6531
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_fab32e0d_738a_4744_8dd6_c16cf7239b86
boundary condition: true
constant: false
is: SBO:0000252
is: Q5QPH3
is encoded by: hsa:55902
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: ACSS2

metaR DESAT24 1
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: false
product: MODEL1310110059#
type: Reaction
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ

metaM ksii core2 pre7 g
initial amount: NaN
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: C00130
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 7
has only substance units: false
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
boundary condition: false
type: Species

metaM nadp c
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

metaM lnlc r
is: CHEBI:30245
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial amount: NaN
is: SBO:0000247
constant: false
name: linoleate
is: HMDB00673

metaR RETFA
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110059#
name: retinol acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_88274b29_81a2_4a37_84ae_14bf11cf9fb0
type: Species
is: B3KXK1
initial amount: NaN
name: SLC26A9
boundary condition: true
is: SBO:0000252
is encoded by: hsa:115019
has only substance units: false
initial concentration: NaN
constant: false

metaR ACACT5p
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000176
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
reversible: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR AKR1D2
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.1.3
type: Reaction
product: MODEL1310110059#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110059#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_0bd067b8_dbff_44b0_96ce_0ed89042e65b
initial amount: NaN
constant: false
is: SBO:0000252
is: E2QRH8
has only substance units: false
is encoded by: hsa:5332
name: PLCB4
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_77b01c99_2260_42d4_8414_215da8fc609d
is: P23677
constant: false
type: Species
initial concentration: NaN
has only substance units: false
name: ITPKA
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3706

metaM dctp n
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: SBO:0000247
constant: false
is: HMDB00998
initial concentration: 1.0
is: C00458
name: dCTP
is: CHEBI:16311

metaR TETHEX3t
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110059#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: fatty acid transport via diffusion
is described by: ECO:0000000

metaR DM datp m
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dATP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_35548dbb_79fe_46e2_bd5f_dfe67d2e2630
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: NDUFA10
is: O95299
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4705

metaM prostge1 c
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57397
name: prostaglandin E1(1-)
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01442

metaM tethex3 c
boundary condition: false
is: HMDB02007
initial amount: NaN
name: tetracosahexaenoic acid, n-3
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_a79a1879_16e3_4f7d_8779_eaba8e0a7434
constant: false
is: P48651
is encoded by: hsa:9791
initial concentration: NaN
has only substance units: false
name: PTDSS1
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaR SBTR
is version of: http://identifiers.org/ec-code/1.1.1.21
name: D-sorbitol reductase
modifier: MODEL1310110059#
reversible: false
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reactant: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.2

http://identifiers.org/biomodels.db/MODEL1310110059#_b6dad872_fa1d_477a_a2e2_ca93b69da20f
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55967
has only substance units: false
is: F8VQS7
constant: false
initial amount: NaN
name: NDUFA12
initial concentration: NaN
type: Species

metaM HC02216 e
has only substance units: false
is: CHEBI:28922
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta

metaR r0541
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176

metaR FAOXC141C121m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaR r0642
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#
is: SBO:0000176
reversible: true
product: MODEL1310110059#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM dlnlcgcoa m
has only substance units: false
is: SBO:0000247
type: Species
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false
is: CHEBI:27979
boundary condition: false
initial concentration: 1.0

metaM dudp n
type: Species
initial amount: NaN
is: CHEBI:60471
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: dUDP(3-)
initial concentration: 1.0

metaR 6THFtl
is: SBO:0000185
kinetic law: MODEL1310110059#
reversible: false
name: 6-glutamyl-THF transport, lysosomal
product: MODEL1310110059#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_177d851f_63bd_4c34_8ac3_458eaa17cafe
has only substance units: false
is encoded by: hsa:8503
name: PIK3R3
type: Species
initial amount: NaN
is: Q92569
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR MANt4
reversible: true
fast: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
name: D-mannose transport via sodium cotransport
product: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_74afd776_325b_47d5_9eb2_21d9df606bf6
name: INPP4B
has only substance units: false
constant: false
type: Species
is encoded by: hsa:8821
is: O15327
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r0643
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
kinetic law: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110059#
is: SBO:0000176
fast: false
reactant: MODEL1310110059#

metaM tmndnc c
name: timnodonic acid C20:5, n-3
is: SBO:0000247
has only substance units: false
is: HMDB01999
initial amount: NaN
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/446284
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110059#_7b02f2b0_edcf_4b37_83c2_d87f815008f1
name: PLCXD2
is: SBO:0000252
constant: false
is: Q0VAA5
is encoded by: hsa:257068
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR LNLNCACRNt
modifier: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110059#
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110059#
is: SBO:0000185
reversible: false
fast: false
product: MODEL1310110059#

metaM dudp m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: dUDP(3-)
boundary condition: false
type: Species
is: CHEBI:60471
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
is: HMDB01000

metaR r1919
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false

metaM s2l2n2m2masn e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: C00255
initial amount: NaN
type: Species
is: HMDB00244
name: de-Fuc form of PA6
is: SBO:0000247
is: CHEBI:3554
has only substance units: false
constant: false

metaM tdchola e
constant: false
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
initial amount: NaN
is: HMDB00951
is: CHEBI:9407
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_f8e83b93_213e_4d6e_a78c_b53245145479
initial concentration: NaN
has only substance units: false
is: P51553
boundary condition: true
name: IDH3G
type: Species
constant: false
is encoded by: hsa:3421
is: SBO:0000252
initial amount: NaN

metaM tethex3 e
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
boundary condition: false
constant: false
type: Species
has only substance units: false
name: tetracosahexaenoic acid, n-3
initial concentration: 1.0
is: SBO:0000247
is: HMDB02007
initial amount: NaN

metaM hdcoa m
is: SBO:0000247
name: Hexadecenoyl-CoA (n-C16:1CoA)
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false
type: Species
is: HMDB06532
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR G12MT2 L
is: SBO:0000176
reversible: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:

metaM ksi deg39 l
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: HMDB00143
initial amount: NaN
name: keratan sulfate I, degradation product 39

metaM thcholstoic x
is: HMDB03873
is: CHEBI:18402
initial amount: NaN
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_6c8bb6c4_db29_4366_8d3c_566bb3ccb681
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q93088
is encoded by: hsa:635
type: Species
has only substance units: false
name: BHMT
constant: false

metaM HC01180 c
is: CHEBI:58694
initial amount: NaN
name: D-tagatofuranose 1,6-bisphosphate(4-)
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaR PIt7
type: Reaction
reversible: true
name: phosphate transport in/out via three Na+ symporter
is described by: ECO:0000269
modifier: MODEL1310110059#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaR S6TASE3ly
modifier: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
kinetic law: MODEL1310110059#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true

metaM gluside hs r
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:18368
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_835df1a8_700b_4aba_8f51_cc73cbb7e783
name: ME2
initial concentration: NaN
is: P23368
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4200

metaM 10fthf5glu e
constant: false
initial amount: NaN
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](5)
is: CHEBI:57454
type: Species
is: HMDB00972
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C40H45N11O19 CHARGE: -6

metaR r0641
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.4
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
type: Reaction
fast: false
is: SBO:0000176

metaM fuc L l
is: CHEBI:18287
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
name: L-fucose
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial amount: NaN
boundary condition: false

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00951
is: CHEBI:9407
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_eced80f8_c30b_4d95_af9d_8b46cc241365
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:M68895
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _M68895_1_c

http://identifiers.org/biomodels.db/MODEL1310110059#_64fb903f_f77a_4e55_a4e3_bafdfd1dc4d5
is: P30566
has only substance units: false
is encoded by: hsa:158
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: ADSL
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_6e90161d_c45c_4bc1_a2c4_51bfeb367158
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:224
boundary condition: true
initial amount: NaN
is: P51648
name: ALDH3A2

metaM ksi pre3 g
is: C00130
is: CHEBI:58053
constant: false
notes: FORMULA: C93H152N6O67X CHARGE: -1
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00175
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 3
initial concentration: 1.0

metaR FAOXC18C18OHm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR 6THFtm
product: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
fast: false
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110059#
name: 6-glutamyl-THF transport,m mitochondrial

metaR NAt3 1
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
name: sodium proton antiporter (H:NA is 1:1)
product: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000185
fast: false
modifier: MODEL1310110059#
type: Reaction

metaR MG2er
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110059#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110059#
type: Reaction
reversible: false
reactant: MODEL1310110059#

metaR r0647
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110059#
name: Spontaneous reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:

metaM txa2 r
initial concentration: 1.0
is: CHEBI:57445
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
name: thromboxane A2(1-)
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01452
initial amount: NaN

metaR ETF
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
name: electron transfer flavoprotein
fast: false
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
reversible: false
kinetic law: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110059#

metaM gluside hs c
constant: false
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
has only substance units: false
name: D-glucosyl-N-acylsphingosine
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM dhf l
boundary condition: false
has only substance units: false
name: dihydrofolate(2-)
is: CHEBI:57451
is: SBO:0000247
constant: false
is: HMDB01056
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

metaR RE3326M
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
modifier: MODEL1310110059#
type: Reaction
name: RE3326
product: MODEL1310110059#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_428cec34_7c55_4a8c_80bf_23c269a2d6fd
is encoded by: hsa:29920
type: Species
initial amount: NaN
name: PYCR2
is: Q96C36
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaR RE0830N
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
name: RE0830
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
fast: false
reversible: true
reactant: MODEL1310110059#

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_4ca617fc_b4cf_40b4_82c7_2d3e1a041eeb
type: Species
is: SBO:0000252
is: Q96RQ3
initial concentration: NaN
constant: false
name: MCCC1
is encoded by: hsa:56922
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_4198ba09_5234_49f6_91a1_a4baf76e9cac
name: SUOX
is encoded by: hsa:6821
has only substance units: false
constant: false
boundary condition: true
type: Species
is: P51687
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM thm c
initial amount: NaN
is: C00378
name: Thiamin
is: SBO:0000247
notes: FORMULA: C12H17N4OS CHARGE: 1
is: HMDB00235
type: Species
is: CHEBI:0
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR RE1517M
is: SBO:0000176
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
name: RE1517
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110059#

metaR SACCD4m
fast: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.8
reversible: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM

metaM elaid c
is: CHEBI:30825
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: elaidate
is: HMDB00573
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM xol7aone r
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01993
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247
boundary condition: false
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one

http://identifiers.org/biomodels.db/MODEL1310110059#_8f4070dc_962a_431e_b18e_b83f919712c8
boundary condition: true
has only substance units: false
is encoded by: hsa:10768
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: AHCYL1
initial concentration: NaN

metaR FAOXC163Gm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM octdececoa c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB06351
is: SBO:0000247
name: octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
has only substance units: false

metaR PAPStg
modifier: MODEL1310110059#
name: 3'-Phosphoadenylyl sufate Golgi transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
product: MODEL1310110059#

metaR MM7B2g
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reactant: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110059#

metaM HC00900 c
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: CHEBI:30860
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: Methylmalonate
has only substance units: false

metaR DGCHOLtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is: SBO:0000185
reversible: true
name: bile acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110059#_7be0fcf0_dc7d_483d_9623_07fa6394ffc5
is encoded by: hsa:284273
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: ZADH2
is: Q8N4Q0
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_9fcef70e_08e6_4ac3_86fe_5fbab782b304
name: CHST4
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q8NCG5
is encoded by: hsa:10164
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_629b2025_e9b8_4fc3_ae0d_c9ed6425cc2d
type: Species
name: ST3GAL3
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6487
is: SBO:0000252
initial concentration: NaN

metaR P5CR
reactant: MODEL1310110059#
is described by: ECO:0000134
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: false
name: pyrroline-5-carboxylate reductase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is: SBO:0000176
type: Reaction

metaR CRNt
fast: false
name: L-carnitine reversible transport
is: SBO:0000185
product: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
kinetic law: MODEL1310110059#
reversible: true

metaR GLCNACASE4ly
modifier: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
product: MODEL1310110059#
is: SBO:0000176

metaM c226coa m
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C16169
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
is: http://identifiers.org/pubchem.compound/47205479
name: cervonyl coenzyme A
initial concentration: 1.0
initial amount: NaN

metaM tmndnc e
name: timnodonic acid C20:5, n-3
boundary condition: false
has only substance units: false
is: HMDB01999
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/446284
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM ksii core2 pre10 g
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067

metaM naglc2p L c
type: Species
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:18278
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM elaid e
type: Species
has only substance units: false
is: HMDB00573
initial concentration: 1.0
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
name: elaidate
initial amount: NaN
is: SBO:0000247
is: CHEBI:30825
boundary condition: false

metaR DUMPtn
is: SBO:0000185
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: dUMP nuclear transport
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110059#

metaR r2389
kinetic law: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM succ m
is: CHEBI:30031
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Succinate
is: SBO:0000247
is: C00042
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
is: HMDB00254
has only substance units: false

metaM tchola e
name: taurocholic acid
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0
constant: false
has only substance units: false

metaM 2octdectecoa x
is: http://identifiers.org/pubchem.compound/5280355
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false
name: 2,6,9,12-octadecatetraenoylcoa
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR 4MOPte
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: true
name: Transport of 4-methyl-2-oxopentanoate
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110059#
is described by: ECO:0000134
type: Reaction

metaR r0644
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
reversible: true
is: SBO:0000176

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110059#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000

metaR VALTA
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
name: valine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
is described by: ECO:0000269
fast: false

metaM dhf m
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57451
name: dihydrofolate(2-)
is: HMDB01056

http://identifiers.org/biomodels.db/MODEL1310110059#_a8a7d623_8a9b_4e2f_9e9d_062d04f1ec2d
name: SLC8A2
is encoded by: hsa:6543
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9UPR5
has only substance units: false

metaM srtn e
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00259
constant: false
initial amount: NaN
name: serotonin(1+)
has only substance units: false
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247

metaR MTHFDm
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
product: MODEL1310110059#
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
is: SBO:0000176

metaM gluside hs g
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
has only substance units: false
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
type: Species
is: CHEBI:18368
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_b89ba04f_8f59_4c44_92aa_d742c0a28919
initial amount: NaN
has only substance units: false
is encoded by: hsa:10678
name: B3GNT2
boundary condition: true
constant: false
is: Q9NY97
is: SBO:0000252
initial concentration: NaN
type: Species

metaM pail5p hs c
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57795
has only substance units: false

metaR ASPGLUm
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
type: Reaction
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110059#

metaR r2388
reversible: false
product: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110059#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110059#

metaR FAOXC2051843m
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110059#
name: Beta oxidation of fatty acid
reactant: MODEL1310110059#
modifier: MODEL1310110059#
fast: false

metaR RE1530C
fast: false
product: MODEL1310110059#
is: SBO:0000176
type: Reaction
reversible: true
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR GLCAASE4ly
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction

metaR FUM
modifier: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
name: fumarase
is version of: http://identifiers.org/ec-code/4.2.1.2
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR OMPDC
name: orotidine-5'-phosphate decarboxylase
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.10
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
modifier: MODEL1310110059#

metaR r0549
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/1.6.5.3
modifier: MODEL1310110059#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.1.1.17
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.6.99.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110059#
product: MODEL1310110059#

metaR MDH
is: SBO:0000176
name: malate dehydrogenase
type: Reaction
modifier: MODEL1310110059#
product: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (130752.1) or (4190.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:Biochemical
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.37
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_04729c78_d46e_489b_93a0_8a63663454e1
is encoded by: hsa:6240
type: Species
initial amount: NaN
name: RRM1:RRM2
constant: false
has part: P23921
is: SBO:0000297
boundary condition: true
is encoded by: hsa:6241
has part: P31350
initial concentration: NaN
has only substance units: false

metaR HESTRATRIOLtr
kinetic law: MODEL1310110059#
is: SBO:0000185
reversible: true
name: hydroxylated estrogen derivative transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000

metaR r2387
modifier: MODEL1310110059#
is: SBO:0000185
reversible: false
product: MODEL1310110059#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#

metaM eitetcoa x
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
name: 5,8,11,14-eicosatetraenoylcoa
type: Species
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN

metaR ACETONEt2
is: SBO:0000185
modifier: MODEL1310110059#
is described by: ECO:0000269
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110059#
fast: false
type: Reaction
name: acetone transport via proton symport

metaR NRPPHRSULT
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.8.2.1
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000269
name: Norepinephrine Sulfotransferase
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_dc9da04e_34c0_47e6_ad90_6716c6b9b6ae
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2686
is: A0PJJ9
name: GGT7
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM srtn c
type: Species
has only substance units: false
is: HMDB00259
constant: false
initial amount: NaN
name: serotonin(1+)
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR 3AIBTm
is described by: ECO:0000304
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.19
type: Reaction
name: L-3-aminoisobutyrate transaminase, mitochondrial
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

metaM thcholstoic r
type: Species
initial concentration: 1.0
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: CHEBI:18402

metaR r0860
fast: false
name: Utilized transport
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.27
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
reversible: true
modifier: MODEL1310110059#
product: MODEL1310110059#

metaR HSAT1ly
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110059#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
fast: false

metaM adrncoa m
is: SBO:0000247
constant: false
initial amount: NaN
name: adrenyl coenzyme A
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
has only substance units: false
boundary condition: false
type: Species

metaR r2386
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110059#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110059#

metaR PGMT
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
modifier: MODEL1310110059#
fast: false
is: SBO:0000176
is described by: ECO:0000134
name: phosphoglucomutase
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR ACONTm
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
modifier: MODEL1310110059#
name: Aconitate hydratase
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ea0ab5ad_9cbb_42ed_aa11_89f06a5ca7eb
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:6508
constant: false
name: SLC4A3
initial amount: NaN

metaM lgnccoa x
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
name: lignocericyl coenzyme A
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06526
boundary condition: false

metaR NACHEX15ly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110059#
modifier: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_0e396cca_ec21_4d1d_afc4_a7574310b428
initial amount: NaN
is encoded by: hsa:W74642
name: _W74642_1_c
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaR r2385
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
fast: false

metaR 5MTHFt
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: true

metaR DTDPtn
product: MODEL1310110059#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dTDP nuclear transport
is: SBO:0000185

metaM tym c
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: CHEBI:327995
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
name: tyraminium
initial concentration: 1.0
is: HMDB00306
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_7be765c5_9203_48c7_90a7_c110bf25a0ab
boundary condition: true
name: SLC25A15
type: Species
constant: false
has only substance units: false
is: Q9Y619
is encoded by: hsa:10166
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r0321
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.3.5.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_9073d9d1_f27e_4f83_be0f_e64c197c2c5f
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: PIP4K2B
is: P78356
is encoded by: hsa:8396
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_e0ee7ff7_11f5_462a_b813_0f072abdfb87
is encoded by: hsa:6120
is: SBO:0000252
is: Q96AT9
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: RPE
boundary condition: true
type: Species

metaM dcacoa m
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Decanoyl-CoA (n-C10:0CoA)
is: C05274
type: Species
constant: false
boundary condition: false
is: HMDB06404
is: CHEBI:61430

metaM 2amac c
is: HMDB03609
initial amount: NaN
name: 2-aminoacrylic acid
constant: false
is: CHEBI:17123
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
initial concentration: 1.0

metaM CE2418 m
is: HMDB11123
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28387
constant: false
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
type: Species
has only substance units: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_1d30673d_9c73_4f06_ae50_f17f231c1e29
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: B7Z428
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10020
name: GNE
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_adf3f184_7d15_45ce_9bac_72677adf8c4e
is: Q14442
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:5283
is: SBO:0000252
initial amount: NaN
name: PIGH
boundary condition: true

metaR SEBACACT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_8e6eacd0_21d5_4fcf_94c2_14731453ef04
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: INPP4A
is: SBO:0000252
is encoded by: hsa:3631
type: Species
has only substance units: false

metaR FUMAC
is version of: http://identifiers.org/ec-code/3.7.1.2
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
name: fumarylacetoacetase

metaR r1814
name: Y+LAT2 Utilized transport
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
reversible: false
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_06f00c13_0955_43a6_97e1_b78c7cefc54c
is encoded by: hsa:7498
type: Species
is: SBO:0000252
boundary condition: true
name: XDH
constant: false
initial concentration: NaN
is: P47989
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_fbcf115f_60cc_4dfe_aa53_643e35e1f3af
type: Species
initial amount: NaN
is encoded by: hsa:515
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000297

metaR ACNACNGALGBSIDEtg
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: acnacngalgbside hs intracellular transport
fast: false
reversible: true
is: SBO:0000185
type: Reaction

metaM cspg b l
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36005
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial amount: NaN
is: HMDB02183
type: Species
has only substance units: false

metaR r2384
type: Reaction
reversible: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM dhf c
initial amount: NaN
has only substance units: false
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056
name: 7,8-Dihydrofolate
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: C00415
initial concentration: 1.0

metaR CORE2GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false
reversible: false
is described by: ECO:0000000
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
modifier: MODEL1310110059#
reactant: MODEL1310110059#

metaR MELATNOX
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.48
name: Melatonin:NADP oxidoreductase
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
fast: false
reversible: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.14.14.1
modifier: MODEL1310110059#

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_e91bfdbf_1a2e_400f_98b0_e49990cf89c9
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: B4GALT2
is: O60909
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8704

metaR GPIAT
is described by: ECO:0000269
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
reversible: false
modifier: MODEL1310110059#
name: glucosaminylphosphatidyl inositol acetyltransferase
type: Reaction
product: MODEL1310110059#
is: SBO:0000176

metaM hs deg6 l
initial concentration: 1.0
type: Species
is: SBO:0000247
name: heparan sulfate, degradation product 6
has only substance units: false
is: HMDB06210
boundary condition: false
constant: false
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_b88642c9_9c2d_4148_a551_325b5e15fe3a
constant: false
is: O75907
is encoded by: hsa:8694
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: DGAT1
boundary condition: true
initial concentration: NaN
type: Species

metaR UDPGLCAter
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
modifier: MODEL1310110059#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport

metaR EX sfcys LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sulfocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_5da0a885_299b_4159_9885_18c61ea31db5
boundary condition: true
initial concentration: NaN
name: PIGO
type: Species
is: Q8TEQ8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84720
constant: false
has only substance units: false

metaR r1815
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is: SBO:0000185
reactant: MODEL1310110059#
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_38b97598_3d80_4b02_92d2_ba1ade725615
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: GALNT14
is encoded by: hsa:79623
is: Q96FL9
constant: false
type: Species

metaM ksi pre28 g
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 28
initial amount: NaN
initial concentration: 1.0
is: C00130
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00175
boundary condition: false
type: Species

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

metaM c226coa c
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: cervonyl coenzyme A
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169

metaR NDP10ex
modifier: MODEL1310110059#
is described by: ECO:0000269
name: nucleoside-diphosphatase (IDP), extracellular
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
is: SBO:0000176

metaM pnto R e
constant: false
is: HMDB00210
name: (R)-Pantothenate
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
type: Species
is: CHEBI:7916
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM hdcoa c
is: SBO:0000247
name: Hexadecenoyl-CoA (n-C16:1CoA)
is: HMDB06532
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
constant: false

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM thcholstoic m
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
is: HMDB03873
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

metaM ksii core2 deg7 l
is: CHEBI:16953
type: Species
boundary condition: false
is: HMDB00812
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C44H73N4O30X CHARGE: 0
constant: false
initial concentration: 1.0
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 7

metaM prpp c
initial concentration: 1.0
is: HMDB00280
is: C00119
type: Species
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial amount: NaN
is: CHEBI:58017
boundary condition: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate

metaR r1816
is described by: ECO:0000000
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hestratriol r
type: Species
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
initial concentration: 1.0
name: 4,17 dihydroxy estradiol
initial amount: NaN
is: HMDB05896
has only substance units: false

metaR r1921
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110059#
name: Y+LAT2 Utilized transport

metaR r2443
reversible: false
kinetic law: MODEL1310110059#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaM 2obut c
initial amount: NaN
boundary condition: false
is: C00109
is: SBO:0000247
is: CHEBI:16763
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: 2-Oxobutanoate
is: HMDB00005

metaR S6TASE24ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110059#
type: Reaction

metaM ksi deg7 l
has only substance units: false
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 7
is: SBO:0000247
boundary condition: false
is: CHEBI:16953
is: HMDB00812
initial concentration: 1.0
constant: false

metaM dcacoa x
initial amount: NaN
is: SBO:0000247
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
is: C05274
boundary condition: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
type: Species
constant: false
is: HMDB06404
has only substance units: false

metaR r2382
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110059#
fast: false
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

metaR r0758
is described by: ECO:0000000
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
reversible: true
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
fast: false
kinetic law: MODEL1310110059#
type: Reaction

metaR MGSA
fast: false
product: MODEL1310110059#
name: methylglyoxal synthase
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD

metaR 34HPPOR
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110059#
is described by: ECO:0000269
reactant: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.27
reversible: false
product: MODEL1310110059#
type: Reaction
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
kinetic law: MODEL1310110059#
is: SBO:0000176

metaR C50CPT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_4180a6fb_9389_4050_a543_bd3b3ac02afb
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:4758
has only substance units: false
name: NEU1
boundary condition: true
initial amount: NaN
is: Q99519

http://identifiers.org/biomodels.db/MODEL1310110059#_31ad4e0a_83e4_444e_ade8_b56792447626
constant: false
initial concentration: NaN
name: NME1
initial amount: NaN
is encoded by: hsa:4830
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaM octdececoa m
is: SBO:0000247
name: octadecenoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
type: Species

metaM HC00900 m
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30860
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
name: Methylmalonate

metaR XOLDIOLONEt
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
is: SBO:0000185
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000

metaR XYLtly
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: Xylose efflux from lysosome
reactant: MODEL1310110059#

metaR RETNt
product: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
name: retinoic acid transport
type: Reaction
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR r2381
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR BALABETAtc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

metaR GCCam
type: Reaction
is described by: ECO:0000269
name: glycine-cleavage complex (lipoylprotein), mitochondrial
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
reactant: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
product: MODEL1310110059#

metaM adrncoa c
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
initial concentration: 1.0
name: adrenyl coenzyme A
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: C16170

http://identifiers.org/biomodels.db/MODEL1310110059#_da0adf57_30a8_454e_8a03_a74c47a894b7
initial concentration: NaN
is: P18859
boundary condition: true
has only substance units: false
is encoded by: hsa:522
name: ATP5J
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR NDPK7n
modifier: MODEL1310110059#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
is: SBO:0000176

metaM pnto R c
is: HMDB00210
constant: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
initial concentration: 1.0
is: CHEBI:7916
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: (R)-Pantothenate

metaR C4x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaM xylu L c
type: Species
name: L-xylulose
initial amount: NaN
constant: false
is: HMDB00751
initial concentration: 1.0
is: CHEBI:17399
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
has only substance units: false

metaR r2380
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#

metaM HC02180 e
initial concentration: 1.0
initial amount: NaN
name: thromboxane-b2
type: Species
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963

http://identifiers.org/biomodels.db/MODEL1310110059#_18705290_38db_4451_8914_c0a3045bf783
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000297
is encoded by: hsa:5277
is encoded by: hsa:9091
type: Species
has only substance units: false
is encoded by: hsa:5279
has part: P57054
initial concentration: NaN
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: B2RAU6

metaM prpp e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial amount: NaN
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
boundary condition: false
constant: false
is: HMDB00280
is: CHEBI:58017

metaM 5mta c
is: HMDB01173
is: SBO:0000247
is: C00170
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17509
name: 5-Methylthioadenosine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_1fa7f7da_0621_4745_84de_c6f80e06e52c
constant: false
boundary condition: true
name: CHAT
initial concentration: NaN
is encoded by: hsa:1103
is: SBO:0000252
initial amount: NaN
type: Species
is: D3DX95
has only substance units: false

metaR DPHMBDCm
fast: false
kinetic law: MODEL1310110059#
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_41f7a07b_e905_4aeb_80c3_2e028327092d
has only substance units: false
initial amount: NaN
is: Q04828
is: SBO:0000252
type: Species
boundary condition: true
name: AKR1C1
constant: false
initial concentration: NaN
is encoded by: hsa:1645

metaM 4hoxpacd c
is: SBO:0000247
initial amount: NaN
is: CHEBI:15621
constant: false
initial concentration: 1.0
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
type: Species
name: (4-hydroxyphenyl)acetaldehyde
has only substance units: false
is: HMDB03767
boundary condition: false

metaR GGLUCT
is described by: ECO:0000269
name: gamma-glutamylcyclotransferase
fast: false
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
reversible: false
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.2.4
type: Reaction
modifier: MODEL1310110059#

metaR 3HKYNAKGAT
reactant: MODEL1310110059#
is described by: ECO:0000304
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_6539b392_6d5f_47db_a47d_b70b3427f0e5
is encoded by: hsa:522
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ATP5J
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaR r0129
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
reversible: true

metaR C180CPT1
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110059#
name: production of stearoylcarnitine
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110059#_7adbc93a_e20d_4918_8a32_798808961763
initial concentration: NaN
has only substance units: false
name: SLC7A8:SLC3A2
has part: Q9UHI5
initial amount: NaN
is encoded by: hsa:23428
constant: false
type: Species
is: SBO:0000297
boundary condition: true

metaR NDPK7m
reactant: MODEL1310110059#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000254
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dCDP), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR BPNT
name: 3',5'-bisphosphate nucleotidase
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.7
modifier: MODEL1310110059#
type: Reaction
fast: false
product: MODEL1310110059#
reversible: false

metaR r0755
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
fast: false
kinetic law: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
is: SBO:0000176
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaM nrvnccoa c
initial concentration: 1.0
is: C16532
is: SBO:0000247
type: Species
name: nervonyl coenzyme A
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1

metaM 13 cis retn r
constant: false
name: 13-cis-retinoate
type: Species
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: http://identifiers.org/pubchem.compound/7847414
is: HMDB06219
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: D00348
is: SBO:0000247

metaR UMPK3n
name: UMP kinase (UTP),nuclear
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_e3a9ef8c_855c_4442_96a6_1634fbde669f
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:126
name: ADH1C
initial amount: NaN
is: P00326

metaM tchola c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
has only substance units: false
is: HMDB00036
is: CHEBI:36257
type: Species
constant: false
name: taurocholic acid

metaR FAOXC13C11m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_42b4eb5d_2dcd_4b9f_9e27_afb4f6e67efb
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PTGDS
constant: false
type: Species
is encoded by: hsa:5730
is: P41222

metaR NACHEX27ly
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
reactant: MODEL1310110059#
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_00f1020c_60bb_4fc4_b220_49cee26945b6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O94925
boundary condition: true
constant: false
is encoded by: hsa:2744
name: GLS
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_c78aed61_7209_48f2_a745_57ed5d40ba33
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:65263
initial concentration: NaN
name: PYCRL
initial amount: NaN
has only substance units: false
is: Q53H96

metaR C180CPT2
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
product: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: carnitine O-stearoyl transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110059#
reversible: false
is described by: ECO:0000269

metaR r0754
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_ff9b2e86_03c1_44c7_bd11_113a45ce7481
constant: false
is encoded by: hsa:257202
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P59796
initial amount: NaN
name: GPX6
has only substance units: false
type: Species

metaM galgluside hs g
has only substance units: false
is: SBO:0000247
name: galactosyl glucosyl ceramide
initial amount: NaN
constant: false
is: HMDB00295
boundary condition: false
type: Species
is: CHEBI:58223
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: C00015

metaM HC02180 c
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
is: CHEBI:28728
is: SBO:0000247
initial amount: NaN
name: thromboxane-b2
has only substance units: false

metaR ACNACNGALGBSIDEte
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
fast: false
name: acnacngalgbside hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
type: Reaction
is: SBO:0000185

metaM 5mta e
name: 5-Methylthioadenosine
is: SBO:0000247
is: HMDB01173
is: C00170
constant: false
notes: FORMULA: C11H15N5O3S CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:17509
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_7f9c2003_d75f_4b96_894c_3b4e48cd894b
initial amount: NaN
type: Species
is: SBO:0000252
name: DGKI
is encoded by: hsa:9162
is: O75912
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_436efba9_7fe1_4edb_8546_f12cf54257dd
initial concentration: NaN
is encoded by: hsa:2639
boundary condition: true
name: GCDH
type: Species
is: Q92947
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaR FATP6t
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.7
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110059#
type: Reaction
name: fatty acid electroneutral transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_85196817_ef06_4a74_8b4f_99404277ccb0
type: Species
boundary condition: true
is: SBO:0000252
is: Q7GXY9
initial amount: NaN
name: ND2
is encoded by: hsa:4536
has only substance units: false
constant: false
initial concentration: NaN

metaR r0753
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
modifier: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110059#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_69f06cc5_5763_4a10_b5dc_02afcbff4bfe
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI222095
name: _AI222095_1_m
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_5a2fe0ba_8005_4285_ad92_e402a99762af
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2030
has only substance units: false
constant: false
boundary condition: true
name: SLC29A1
type: Species
is: Q99808
is: SBO:0000252

metaR RE3050R
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: RE3050
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110059#

metaR PGLer
reversible: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
type: Reaction
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269
name: 6-phosphogluconolactonase, endoplasmic reticulum

metaR FAOXC2051843x
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000269
fast: false
reversible: false
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
product: MODEL1310110059#
reactant: MODEL1310110059#

metaR r2055
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110059#
is: SBO:0000185
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_be77c870_4889_4194_9eac_acd9edf8ced9
name: GPX4
is: P36969
is: SBO:0000252
is encoded by: hsa:2879
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM s2l2n2m2mn l
initial amount: NaN
notes: FORMULA: C76H123N5O57 CHARGE: -2
has only substance units: false
is: HMDB00573
is: SBO:0000247
is: CHEBI:30825
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)

metaR PHCHGSm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
reactant: MODEL1310110059#
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110059#
type: Reaction
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110059#

metaR r0781
fast: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
modifier: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reversible: true
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110059#_5cb5c50f_e8d0_46e5_aa01_c9d817f77b4c
is encoded by: hsa:132789
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: GNPDA2
boundary condition: true
is: Q8TDQ7

metaR NADHtru
reversible: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
name: NADH transporter, endoplasmic reticulum
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
fast: false
kinetic law: MODEL1310110059#

metaM xoldiolone c
is: SBO:0000247
initial concentration: 1.0
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: CHEBI:28477
is: HMDB02197
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457

metaM txa2 e
boundary condition: false
constant: false
is: HMDB01452
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: thromboxane A2(1-)

metaM pmtcrn r
has only substance units: false
name: L-palmitoylcarnitine
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17490
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_cce0ad41_af79_4798_a6f9_9b41137f6e22
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: HSD17B2
type: Species
has only substance units: false
is: P37059
initial amount: NaN
is encoded by: hsa:3294

http://identifiers.org/biomodels.db/MODEL1310110059#_a96b406d_b5ff_48fb_b4ef_a64360858513
name: ALDH3B2
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: P48448
is encoded by: hsa:222

metaM xol7ah2al c
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
has only substance units: false
type: Species
is: CHEBI:27428
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: HMDB06894
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_f2486b48_61c4_4def_a5d6_db0ece798bb5
type: Species
constant: false
is: P51570
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2584
initial amount: NaN
has only substance units: false
name: GALK1

metaR GLNtN1
is described by: ECO:0000269
is: SBO:0000185
name: Glutamine transport (Na, H coupled)
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
modifier: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction

metaR r2083
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_fa473228_6d39_4168_9c56_43a44c62f890
is: Q8TDB8
has only substance units: false
is: SBO:0000252
type: Species
name: SLC2A14
is encoded by: hsa:144195
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM fad m
is: HMDB01248
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
is: CHEBI:16238
constant: false
is: C00016
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized

http://identifiers.org/biomodels.db/MODEL1310110059#_c786f6ae_1c44_4bc9_b5ca_f645d3b5497b
constant: false
type: Species
is: O75489
boundary condition: true
is encoded by: hsa:4722
has only substance units: false
name: NDUFS3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_14a66afc_31db_4906_9a2c_b78627312ade
name: PYCR1
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5831
type: Species
initial amount: NaN
is: A6NFM2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_5aace6a6_94dd_4d9e_95be_fad957b8095a
has part: O60762
is encoded by: hsa:54344
initial amount: NaN
is encoded by: hsa:8813
has part: Q86TM7
name: DPM3:DPM1:DPM2
initial concentration: NaN
is: SBO:0000297
has only substance units: false
boundary condition: true
has part: O94777
type: Species
is encoded by: hsa:8818
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_7caf2645_3d93_42eb_88ca_3ca08deb4c64
name: PDE3B
constant: false
is: A7E2E5
initial amount: NaN
is encoded by: hsa:5140
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_ae67a150_2bc7_477a_bc01_256ae0a5cf49
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM CE2424 m
initial concentration: 1.0
constant: false
is: CHEBI:28387
boundary condition: false
initial amount: NaN
is: HMDB11123
is: SBO:0000247
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
type: Species
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
has only substance units: false

metaM dolp U r
name: dolichyl phosphate(2-)
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
is: CHEBI:57683
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR PDX5PO
modifier: MODEL1310110059#
type: Reaction
name: pyridoxine 5'-phosphate oxidase
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
reversible: true
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000269
kinetic law: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
fast: false

metaR ACCOAgt
modifier: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110059#
name: acetyl-coa transport
product: MODEL1310110059#

metaM hx2coa x
is: C05998
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB06870
name: trans-Hex-2-enoyl-CoA
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/11966188
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_83fcc3e0_11f5_4ef5_b587_532c8fc35bc8
type: Species
is: SBO:0000252
is: E9KL42
has only substance units: false
initial amount: NaN
is encoded by: hsa:641371
constant: false
initial concentration: NaN
boundary condition: true
name: ACOT1

metaR DMATTx
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
name: dimethylallyltranstransferase
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
product: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_febfabaf_ea5d_4ba2_bec3_ae73d67f2ffc
initial amount: NaN
is encoded by: hsa:5315
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: PKM2
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_5ca23def_a970_4180_9ba9_aeb78a8f745e
is: O15269
constant: false
is encoded by: hsa:10558
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: SPTLC1

metaM pcrn m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
boundary condition: false
is: HMDB00824
initial amount: NaN
type: Species
name: propionyl-carnitine
constant: false
is: http://identifiers.org/pubchem.compound/107738

metaM spmd c
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01257
is: CHEBI:57834
is: C00315
is: SBO:0000247
name: Spermidine
initial concentration: 1.0
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
constant: false

metaR r2082
product: MODEL1310110059#
type: Reaction
fast: false
reactant: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_25ea56a6_be13_4329_807f_c0010ab3b140
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
name: IDH3G
is encoded by: hsa:3421
initial concentration: NaN
initial amount: NaN
is: E9PDD5

http://identifiers.org/biomodels.db/MODEL1310110059#_37cdf2c3_05c9_48d9_8d3f_455a268ae9a8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2182
constant: false
has only substance units: false
is: Q5JWV8
type: Species
initial concentration: NaN
boundary condition: true
name: ACSL4

metaR FALDH
name: formaldehyde dehydrogenase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reactant: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
reversible: true
modifier: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaR r0783
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110059#
modifier: MODEL1310110059#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:

metaR r0400
type: Reaction
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000176
reversible: true
fast: false
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_18e67a5b_9d1a_4e22_81d6_5ba395d0719e
boundary condition: true
has only substance units: false
name: SLC22A2
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6582

metaM 2oxoadp m
is: CHEBI:57499
is: HMDB00225
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 2-oxoadipate(2-)

metaR UMPK2
reactant: MODEL1310110059#
fast: false
name: UMP kinase (CTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#

metaM lald D c
has only substance units: false
is: HMDB06458
boundary condition: false
is: SBO:0000247
name: (R)-lactaldehyde
initial amount: NaN
type: Species
is: CHEBI:17167
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
constant: false
initial concentration: 1.0

metaR r2085
reactant: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110059#

metaR NDPK3m
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
is described by: ECO:0000254
fast: false
reversible: true
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_3d8eef77_0dc2_4bf4_b32e_f9a0837c51a6
name: HIBCH
boundary condition: true
is: Q6NVY1
is encoded by: hsa:26275
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_35cd6e44_c83c_4c2b_a52c_6ed30e6ea6e6
has only substance units: false
type: Species
initial concentration: NaN
name: ALPL
boundary condition: true
initial amount: NaN
is encoded by: hsa:249
is: SBO:0000252
constant: false
is: B7Z4Y6

metaR r0784
product: MODEL1310110059#
fast: false
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
type: Reaction
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#

metaR TRPHYDRO2
is version of: http://identifiers.org/ec-code/1.14.16.4
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reactant: MODEL1310110059#
is: SBO:0000176
type: Reaction
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
product: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR 2HBt2
reactant: MODEL1310110059#
name: 2-hydroxybutyrate cotransport with proton
fast: false
product: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000185

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR S6TASE13ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110059#_2c34e825_725c_4b71_b9db_fea0e589824b
is: SBO:0000252
has only substance units: false
name: AK4
is encoded by: hsa:205
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaR r2084
fast: false
product: MODEL1310110059#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110059#

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR FACOAL241
kinetic law: MODEL1310110059#
fast: false
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction

metaR NDPK3n
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction

metaR CITt4 2
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110059#

metaR DLNLCGCRNt
product: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110059#
reversible: false
fast: false

metaR DGCHOLte
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
type: Reaction
name: bile acid intracellular transport
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaR FAOXC181C181OHm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaR PTDCACRNt
reactant: MODEL1310110059#
is described by: ECO:0000000
name: pentadecanoate transport into the mitochondria
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
reversible: false
product: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_67eee658_daa0_4ee5_989e_b36af63daa36
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6898
name: TAT
has only substance units: false
is: P17735
initial concentration: NaN

metaM dpcoa m
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
name: 3'-dephospho-CoA(2-)
is: HMDB01373

metaR CYTK3
kinetic law: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110059#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (CMP)(GTP)
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.3

metaR PHEtec
reversible: true
modifier: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
name: L-phenylalanine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (117247.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false

metaM fad r
is: HMDB01248
boundary condition: false
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false

metaR UMPK4
modifier: MODEL1310110059#
reversible: true
name: UMP kinase (GTP)
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176

metaR ADK3
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
is: SBO:0000176
name: adentylate kinase (GTP)
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
type: Reaction
is described by: ECO:0000269
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.3

metaM guln r
has only substance units: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial concentration: 1.0
name: L-gulonate
boundary condition: false
is: HMDB03290
type: Species
constant: false
is: SBO:0000247
is: CHEBI:13115
initial amount: NaN

metaR ARAB Lt
reversible: true
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000185
name: L-arabinoase extracellular transport
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:

metaM methf c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01354
is: C00445
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
name: 5,10-Methenyltetrahydrofolate
type: Species
is: CHEBI:57455

metaR NACHEX23ly
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110059#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_970fbb92_7775_4fb9_9b14_357c4355ff84
is: Q8IWU9
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:121278
boundary condition: true
name: TPH2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_4c0f8845_57ec_4bca_a780_f976ce8e893d
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC25A12
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:8604
is: O75746
initial concentration: NaN

metaM pmtcrn m
name: L-palmitoylcarnitine
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:17490
type: Species
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_986dc4cc_bb4f_4540_95ff_e2fd59496431
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4722
name: NDUFS3
initial concentration: NaN
is: O75489

metaM dpcoa l
is: HMDB01373
initial concentration: 1.0
boundary condition: false
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_b2ca5093_7126_4146_92a0_5de617947dee
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
has part: P56134
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:9551
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:522

metaR CYTK2
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: cytidylate kinase (dCMP)
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#

metaM co c
name: carbon monoxide
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial concentration: 1.0
is: CHEBI:17245
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01361
constant: false

metaR UMPK3
reversible: true
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
name: UMP kinase (UTP)

metaR GLNALANaEx
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110059#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110059#
reversible: false

metaR EX urea LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urea exchange
type: Reaction

metaR N3Tg
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.122
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
is described by: ECO:0000000

metaR LNLNCACPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110059#
reversible: false
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110059#

metaM txa2 c
is: HMDB01452
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445
is: SBO:0000247
has only substance units: false
boundary condition: false
name: thromboxane A2(1-)
initial amount: NaN

metaR CITt4 4
modifier: MODEL1310110059#
name: citrate transport via sodium symport
reactant: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
fast: false
is described by: ECO:0000006
kinetic law: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD

metaR ACNAMtn
type: Reaction
fast: false
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
product: MODEL1310110059#
name: N-acetylneuraminate nuclear import
kinetic law: MODEL1310110059#

metaR GALASE15ly
is: SBO:0000176
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
product: MODEL1310110059#

metaR DDCRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaR FAOXC122C101m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR r0787
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: false
modifier: MODEL1310110059#

metaR BTNPL
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
product: MODEL1310110059#
name: holocarboxylase synthestase (biotin protein ligase)
is version of: http://identifiers.org/ec-code/6.3.4.10
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR CYTK1
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000269
reactant: MODEL1310110059#
name: cytidylate kinase (CMP)
type: Reaction
reversible: true

metaM cit m
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00158
name: Citrate
is: HMDB00094
is: CHEBI:16947
boundary condition: false
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247

metaR r2080
kinetic law: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110059#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110059#
product: MODEL1310110059#

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

metaR r2081
reversible: true
type: Reaction
kinetic law: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#

metaR MMSAD1m
name: methylmalonate-semialdehyde dehydrogenase
fast: false
is described by: ECO:0000269
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.27
is: SBO:0000176
reversible: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
type: Reaction
product: MODEL1310110059#

metaR FAOXC181C161x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_4819f5b6_8e4f_41f2_b721_dc9982a8675b
is encoded by: hsa:AF080579
name: _AF080579_1_c
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaR UMPK6
reversible: true
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: UMP kinase (dCTP)
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR DOLGLCP Lter
kinetic law: MODEL1310110059#
is: SBO:0000185
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
type: Reaction
product: MODEL1310110059#

metaR GAO1g
type: Reaction
is described by: ECO:0000269
product: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
name: Ganglioside O-acetylation
modifier: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_d5a51b1f_2042_4b5b_9982_efab90002d13
is: O14734
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:10005
name: ACOT8

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR LNLNCACPT2
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
reversible: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_5ec9c657_a616_4a81_81be_7133febf5569
is: P56385
is encoded by: hsa:521
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: ATP5I
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR PRISTCOAtcx
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR FAOXC7C5m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaR GLYAMDTRc
reversible: true
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
is version of: http://identifiers.org/ec-code/2.1.4.1
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110059#
name: glycine amidinotransferase (c)
modifier: MODEL1310110059#
reactant: MODEL1310110059#

metaR Htx
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110059#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
name: H transporter, peroxisome

http://identifiers.org/biomodels.db/MODEL1310110059#_634d13b2_174c_4346_936f_af785988d28f
name: _BE042354_1_m
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:BE042354
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaR UMPK5
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110059#
name: UMP kinase (dATP)
reversible: true
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaR r0788
reversible: true
product: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
modifier: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_31a26aee_2ba0_44e5_94de_e5fbf3acb7d4
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:3423
name: IDS
initial amount: NaN
is: B4DGD7
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_f34a24b7_4014_4fa8_a222_b7e548d54746
is encoded by: hsa:51004
constant: false
initial concentration: NaN
name: COQ6
has only substance units: false
type: Species
is: Q9Y2Z9
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR LSTO1r
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
modifier: MODEL1310110059#
name: Lathosterol oxidase
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.21.6
product: MODEL1310110059#
fast: false
is described by: ECO:0000269

metaR r2369
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110059#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_a00655d7_5bfe_434c_9b19_828e3e6e65a7
name: MAOA
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4128
initial amount: NaN
initial concentration: NaN
constant: false
is: Q53YE7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_fab1903e_773d_452a_9234_0a2fdc42e63a
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10380
boundary condition: true
name: BPNT1
constant: false
has only substance units: false
type: Species
is: O95861
initial amount: NaN

metaM cytd c
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: HMDB00089
initial amount: NaN
is: SBO:0000247
type: Species
name: Cytidine
initial concentration: 1.0
constant: false
boundary condition: false
is: C00475
has only substance units: false

metaM 3hexdtricoa m
type: Species
is: HMDB02288
name: 3,7,10-hexadecatrienoylcoa
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaR DHCHOLESTANATEtm
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
reactant: MODEL1310110059#
name: lipid, flip-flop intracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_30d16009_062c_45a7_989a_531ec103664a
name: CMA1
initial concentration: NaN
initial amount: NaN
is: Q4FEB3
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:1215
is: SBO:0000252
constant: false

metaM C05280 m
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:28002
initial amount: NaN
is: HMDB03952
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
type: Species
constant: false
has only substance units: false
name: cis,cis-3,6-Dodecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110059#_89017c03_7391_48a9_84cd_50e8b0c5a05d
type: Species
has only substance units: false
is: B2RAU6
constant: false
boundary condition: true
name: PIGQ
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9091

metaR FAOXC122x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_f35fd80c_219a_4f6f_ae55_fc53695a5c81
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:AI601100
name: _AI601100_1_m
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r0552
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reversible: true
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.5.1
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

metaM fad e
boundary condition: false
is: C00016
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16238
constant: false

metaR LINKDEG2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reversible: false
kinetic law: MODEL1310110059#
fast: false
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_e560ee06_7489_4309_b5f1_3ec2b5f250cb
has only substance units: false
type: Species
is encoded by: hsa:2806
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P00505
name: GOT2
constant: false
initial concentration: NaN

metaR VALtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
type: Reaction
is: SBO:0000185
reactant: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#
reversible: true
fast: false
name: L-valine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaM fad c
is: C00016
is: HMDB01248
constant: false
is: CHEBI:16238
has only substance units: false
name: Flavin adenine dinucleotide oxidized
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR DNDPt14m
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
name: dUDP transport via dTDP antiport
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
reversible: false
fast: false
type: Reaction

metaR FAOXC61C4m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM HC01403 m
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
constant: false
has only substance units: false
is: CHEBI:28325
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
boundary condition: false

metaR BACCL
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
modifier: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176
product: MODEL1310110059#
name: biotin-[acetyl-CoA-carboxylase] ligase

metaM tethex3coa c
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB06243
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
initial concentration: 1.0
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/47205478
is: C16168
name: tetracosahexaenoyl coenzyme A
has only substance units: false

metaM methf m
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: SBO:0000247
name: (6R)-5,10-methenyltetrahydrofolate
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57455
initial concentration: 1.0
is: HMDB01354

metaM 25aics c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: C04823
has only substance units: false
is: HMDB00797
is: CHEBI:58443
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

metaR r0630
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.3.1
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reversible: true
fast: false
is: SBO:0000176

metaR DCK1n
kinetic law: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
name: Deoxycytidine kinase, nuclear (ATP)
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
product: MODEL1310110059#
is described by: ECO:0000269
fast: false
type: Reaction

metaM ksii core2 deg8 l
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C36H60N3O25X CHARGE: 0
constant: false
is: CHEBI:12936
type: Species
boundary condition: false
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 8
initial amount: NaN
is: SBO:0000247

metaR CERT2rt
product: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
name: ceramide transport protein
modifier: MODEL1310110059#

metaR r0553
is: SBO:0000176
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
kinetic law: MODEL1310110059#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

metaM ade c
is: HMDB00034
type: Species
is: SBO:0000247
is: CHEBI:16708
name: Adenine
constant: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
is: C00147
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_e1a23d09_99e4_404e_8db8_13c64999b28a
is encoded by: hsa:1956
is: SBO:0000252
is: P00533
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: EGFR
initial concentration: NaN
has only substance units: false

metaM c226coa x
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205479
initial concentration: 1.0
has only substance units: false
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
is: C16169

metaR TAURt4 2 r
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: true
name: taurine transport (sodium symport) (2:1)
fast: false
is: SBO:0000185

metaR D LACt2
product: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
name: D-lactate transport via proton symport
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
reversible: true

metaM guln c
is: CHEBI:13115
constant: false
is: HMDB03290
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
name: L-gulonate
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaM ipdp c
initial amount: NaN
name: Isopentenyl diphosphate
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
initial concentration: 1.0
is: CHEBI:128769
type: Species
constant: false
is: HMDB01347
is: C00129
is: SBO:0000247
has only substance units: false

metaR MI145PK
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
reversible: false
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.127
name: inositol-1,4,5-trisphosphate 3-kinase

metaM HC00664 c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
is: CHEBI:58695
name: D-tagatofuranose 6-phosphate(2-)
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_df0a4462_7471_4086_903f_eb7cfa16c454
name: SLC26A4
constant: false
is: O43511
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5172

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM m2mn l
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: HMDB06537
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: SBO:0000247

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR VALt5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Valine reversible mitochondrial transport
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
reversible: true
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000185
product: MODEL1310110059#

metaR SIAASEly
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_adc84633_1859_4035_9deb_4212b8c7eaba
is encoded by: hsa:6581
is: SBO:0000252
initial concentration: NaN
is: Q5SYN6
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: SLC22A3
type: Species

metaR PI34P5K
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110059#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
product: MODEL1310110059#
modifier: MODEL1310110059#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_88924521_23b2_48d5_a7c1_548a6f442fee
type: Species
initial concentration: NaN
is: P42765
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10449
name: ACAA2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_c303bdda_8410_4d3b_97ce_17835c59c8c5
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: PC
boundary condition: true
is encoded by: hsa:5091
is: P11498

metaR THRGLNNaEx
reversible: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
modifier: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)

metaM ru5p D r
initial concentration: 1.0
boundary condition: false
is: HMDB00618
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
type: Species

metaR FACOAL240
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110059#
name: fatty-acid--CoA ligase
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
product: MODEL1310110059#

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
is: SBO:0000176
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000269
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#

metaM ksi deg12 l
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 12
is: HMDB00143
type: Species
constant: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false

metaM CE2431 m
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: cis-deca-4-enoyl-CoA
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
is: CHEBI:57795
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_64111f85_30f1_4c86_b41b_c6af7ab0d12a
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:51251
is: Q9H0P0
name: NT5C3
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaM mlthf c
boundary condition: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
is: CHEBI:15636
type: Species
has only substance units: false
is: C00143
is: SBO:0000247
is: HMDB01533
initial concentration: 1.0
name: 5,10-Methylenetetrahydrofolate
initial amount: NaN

metaM succ e
boundary condition: false
name: succinate(2-)
is: CHEBI:30031
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00254
initial amount: NaN
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247

metaR GALASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_c1af2673_bce9_44ad_a3bd_78b6a28eecde
initial concentration: NaN
has only substance units: false
name: ND6
boundary condition: true
is encoded by: hsa:4541
is: Q7GXZ1
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_7b8b1591_948a_47a9_acc1_788e73f1209e
is: O15270
name: SPTLC2
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:9517
initial concentration: NaN

metaR C6DCc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaM ksi deg6 l
has only substance units: false
name: keratan sulfate I, degradation product 6
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: CHEBI:12936
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
type: Species
boundary condition: false
constant: false

metaR RE1448N
name: RE1448
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR HSD3A2r
is described by: ECO:0000000
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
modifier: MODEL1310110059#
product: MODEL1310110059#
fast: false

metaM cit c
name: Citrate
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
initial concentration: 1.0
constant: false
is: HMDB00094
is: C00158
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_92428904_e3ee_4ce5_ba60_109cd080c818
is: SBO:0000252
constant: false
initial concentration: NaN
is: B4DDW0
name: RDH11
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:51109

metaR ORNt4m
reversible: true
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
fast: false
modifier: MODEL1310110059#
name: ornithine mitochondrial transport exchange with citruline
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction

metaR CLPNDCOAtx
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000

metaM 42A3HP24DB c
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7956
is: C05645
is: HMDB04083
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

metaM 6dhf e
type: Species
name: hexaglutamyl folate (DHF)
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB06563

metaM pcrn x
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/107738
name: propionyl-carnitine
has only substance units: false
is: HMDB00824
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaM dpcoa e
is: SBO:0000247
is: HMDB01373
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: CHEBI:57328
initial amount: NaN
is: C00882
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: Dephospho-CoA

http://identifiers.org/biomodels.db/MODEL1310110059#_4c32f66e_15c0_4e81_8077_2029cbac16b6
constant: false
has only substance units: false
is: B3KXY9
initial amount: NaN
is encoded by: hsa:3098
boundary condition: true
is: SBO:0000252
type: Species
name: HK1
initial concentration: NaN

metaM dpcoa c
constant: false
type: Species
name: Dephospho-CoA
is: SBO:0000247
is: C00882
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01373
is: CHEBI:57328

metaR SPMTDe
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
name: SPMTDe

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaM homoval m
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Homovanillate
boundary condition: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: HMDB00118
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:545959

metaR DNDPt29m
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
fast: false
modifier: MODEL1310110059#
is described by: ECO:0000269
name: dCDP transport via dADP antiport
is: SBO:0000185

metaR ADSL1
reactant: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.2.2
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
name: adenylosuccinate lyase

metaR ALAGLNNaEx
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
is: SBO:0000185
reversible: false
modifier: MODEL1310110059#

metaR HOCTDECCRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaM Ser Thr l
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: protein-linked serine or threonine residue (O-glycosylation site)
boundary condition: false
is: HMDB00224
type: Species
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
constant: false
is: CHEBI:58190

metaR r0556
type: Reaction
kinetic law: MODEL1310110059#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
modifier: MODEL1310110059#
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is: SBO:0000176

metaM 3hexdcrn e
notes: FORMULA: C23H45NO5 CHARGE: 0
name: 3-hydroxyhexadecanoylcarnitine
is: HMDB13336
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_c9faa99c_e767_4872_88d0_773e4b6ac9e0
is encoded by: hsa:23169
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC35D1
type: Species
is: SBO:0000252
boundary condition: true
is: Q9NTN3

metaM pail hs c
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_78340882_6b61_4b8f_a010_37e282c8983f
type: Species
boundary condition: true
initial concentration: NaN
name: ATP5G2
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:517

metaM succ c
constant: false
initial concentration: 1.0
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
is: C00042
boundary condition: false
has only substance units: false
name: Succinate
is: SBO:0000247
initial amount: NaN
is: CHEBI:30031

metaR EX c101crn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

metaR 13DAMPPOX
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000212
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.4.3.21

metaR r0557
is: SBO:0000176
fast: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
product: MODEL1310110059#
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaM 6dhf c
is: HMDB06563
is: SBO:0000247
name: hexaglutamyl folate (DHF)
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaM cit e
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
is: CHEBI:16947
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00094
name: citrate(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_e2fcd84f_43d5_4bc0_b551_145b366d901f
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: NT5M
is: SBO:0000252
initial concentration: NaN
is: Q9NPB1
is encoded by: hsa:56953

metaR ADSL2
is: SBO:0000176
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
reversible: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
kinetic law: MODEL1310110059#
name: adenylosuccinate lyase
is described by: ECO:0000269

metaM pmtcrn x
is: HMDB00222
boundary condition: false
initial concentration: 1.0
name: L-palmitoylcarnitine
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
is: SBO:0000247
is: CHEBI:17490

metaM xol7ah2al m
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0
is: HMDB06894
is: CHEBI:27428
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species

metaR HIStiDF
reversible: false
product: MODEL1310110059#
is: SBO:0000185
name: L-histidine transport via diffusion (extracellular to cytosol)
type: Reaction
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
reactant: MODEL1310110059#
fast: false

metaR S6T2g
is: SBO:0000176
reactant: MODEL1310110059#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000

metaR BTND1
fast: false
modifier: MODEL1310110059#
reversible: false
product: MODEL1310110059#
is described by: ECO:0000269
name: biotinidase (biotin)
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
kinetic law: MODEL1310110059#

metaR SPODM
product: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110059#
is described by: ECO:0000269
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176
name: superoxide dismutase
type: Reaction
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_d195cb13_f677_44bb_96ab_c7fa9a3b0dc1
constant: false
boundary condition: true
is encoded by: hsa:4711
name: NDUFB5
is: O43674
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaR RTOTAL2t
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: RTOTAL2 transport
fast: false

metaR DM T antigen g
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR r0558
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
reversible: true

metaM atp x
constant: false
boundary condition: false
type: Species
name: ATP(4-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:57299
is: HMDB00538
is: C00002
is: SBO:0000247
initial amount: NaN

metaM 3hexdcrn c
name: 3-hydroxyhexadecanoylcarnitine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C23H45NO5 CHARGE: 0
initial concentration: 1.0
is: HMDB13336
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR r0780
modifier: MODEL1310110059#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reactant: MODEL1310110059#
is: SBO:0000176
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is described by: ECO:0000000
reversible: true

metaM phyt x
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00801
is: SBO:0000247
type: Species
name: phytanate
is: CHEBI:37257
initial amount: NaN

metaR r0853
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
fast: false
product: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_44f50e1e_4f74_4a08_88b4_c262f291f0b0
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10861
initial concentration: NaN
name: SLC26A1
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_b39525cd_5faf_42f6_bbfe_0d22af4a27bd
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:491
type: Species
is: Q4J699
name: ATP2B2
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM m1mpdol L c
has only substance units: false
is: CHEBI:28067
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
initial concentration: 1.0
constant: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog

metaR FAOXC10C10OHm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaM ksi pre20 g
name: keratan sulfate I biosynthesis, precursor 20
has only substance units: false
constant: false
is: CHEBI:28067
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
initial concentration: 1.0
is: SBO:0000247

metaM urate c
boundary condition: false
is: C00366
initial amount: NaN
initial concentration: 1.0
name: Urate
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:17775
is: HMDB00289
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

http://identifiers.org/biomodels.db/MODEL1310110059#_c9b402c5_ee0f_4766_8c2a_965997a809bb
initial concentration: NaN
name: PPA1
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: Q15181
is encoded by: hsa:5464

metaR EX 3ivcrn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR NACHEX18ly
type: Reaction
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
reversible: false

metaR ATPH2e
modifier: MODEL1310110059#
is: SBO:0000176
name: ATP diphosphohydrolase
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
fast: false
reactant: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
product: MODEL1310110059#

metaM 3hmbcoa m
is: CHEBI:57312
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: HMDB01356
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false

metaR r2374
reactant: MODEL1310110059#
product: MODEL1310110059#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
fast: false

metaR EX psyltchol LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-taurocholic acid complex
type: Reaction

metaR OBDHc
fast: false
type: Reaction
name: 2-Oxobutanoate dehydrogenase, cytosolic
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
reversible: false

metaR AGMTm
notes: GENE_ASSOCIATION: (79814.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 3.5.3.11 Confidence Level: 4 AUTHORS: PMID:11804860,PMID:11914032,PMID:15028567,PMID:15465778 NOTES:SAB m
reversible: false
name: agmatinase (m)
reactant: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.3.11
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269

metaM prpncoa m
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: CHEBI:57367
is: HMDB02307
is: SBO:0000247
has only substance units: false
type: Species
name: acryloyl-CoA(4-)
boundary condition: false

metaR ALAR
modifier: MODEL1310110059#
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
name: alanine racemase
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000212

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_32cfe130_8545_48b0_9e5a_3839767c465b
type: Species
is encoded by: hsa:84720
has only substance units: false
has part: Q6IB04
boundary condition: true
is encoded by: hsa:5281
initial concentration: NaN
initial amount: NaN
constant: false
name: PIGF:PIGO
is: SBO:0000297

metaM ascb L e
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB00044
is: CHEBI:38290
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
name: L-ascorbate

metaR r0559
type: Reaction
fast: false
reversible: true
is: SBO:0000176
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
modifier: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.5.1.3

http://identifiers.org/biomodels.db/MODEL1310110059#_89e7c62f_5024_4c70_bf4d_fd6d8e0d405b
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:AD000092
name: _AD000092_1_c

metaM fald m
name: formaldehyde
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial amount: NaN
boundary condition: false
is: CHEBI:16842
type: Species
constant: false
is: HMDB01426

metaM pail hs n
boundary condition: false
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR r2373
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000

metaM ksi g
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17140
is: SBO:0000247
is: HMDB01644
name: keratan sulfate I

http://identifiers.org/biomodels.db/MODEL1310110059#_74765290_5063_4337_91dd_278d47efab8b
is: Q02218
is encoded by: hsa:4967
constant: false
initial concentration: NaN
name: OGDH
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_cb632a51_f297_4957_a516_81071f30f1d8
has only substance units: false
initial concentration: NaN
type: Species
name: SCP2
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6342
is: C9JC79

metaR CYStec
product: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14624363,PMID:15659399 NOTES:SAB
is: SBO:0000185
fast: false
reactant: MODEL1310110059#
reversible: true
name: L-cysteine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110059#
is described by: ECO:0000269
type: Reaction

metaM urate e
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00289
is: CHEBI:17775
is: C00366
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_a4f60676_cff8_47fe_bc6f_2e97707dc6f9
is encoded by: hsa:3628
type: Species
constant: false
name: INPP1
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P49441
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_10e37781_42d8_41a3_a4ce_96c7e0b09334
name: IDH3B
has only substance units: false
is encoded by: hsa:3420
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaR DM fol
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_cccbcdeb_bdf9_40c5_89ac_2e8ec14de42c
type: Species
constant: false
name: _AI971036_1_x
is encoded by: hsa:AI971036
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_c69cc6bc_b451_4fb9_8847_20a19b9686e2
initial amount: NaN
name: SLC2A11
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:66035
is: Q8WXF9
is: SBO:0000252
has only substance units: false
constant: false

metaR DCSPTN1CPT1
is described by: ECO:0000269
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
name: carnitine O-palmitoyltransferase

metaR r2376
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110059#_d0811bdf_053e_43bc_b2cd_94effacf486d
is encoded by: hsa:1349
has part: Q02221
is encoded by: hsa:1329
has part: Q7GXY8
is encoded by: hsa:1339
initial concentration: NaN
has part: Q6FGA0
has part: P24311
is encoded by: hsa:1327
has part: P00414
is encoded by: hsa:4514
is encoded by: hsa:1337
has part: P14854
has part: P12074
has part: P15954
boundary condition: true
has part: P09669
is encoded by: hsa:1350
has part: H0UI06
has part: P13073
is encoded by: hsa:84701
type: Species
has part: Q8TF08
is encoded by: hsa:4513
is encoded by: hsa:4512
is encoded by: hsa:1346
has part: Q53YB7
is encoded by: hsa:125965
has part: Q6YFQ2
has part: Q53XN1
is encoded by: hsa:1340
is encoded by: hsa:9377
is: SBO:0000297
constant: false
is encoded by: hsa:170712
is encoded by: hsa:9167
initial amount: NaN
is encoded by: hsa:1347
is encoded by: hsa:1345
is encoded by: hsa:341947
is encoded by: hsa:1351
has part: Q7GXZ8
has only substance units: false
has part: Q7Z4L0
has part: P24310
has part: Q96KJ9
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P20674

metaM biliverd c
initial amount: NaN
name: biliverdin(2-)
is: CHEBI:57991
is: HMDB01008
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_0fde2414_b247_49fb_99d0_ea7b50d141aa
is: P78381
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC35A2
constant: false
is encoded by: hsa:7355
is: SBO:0000252
type: Species

metaR S2L2N2M2MASNtly
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
name: s2l2n2m2masn transport, extracellular to lysosome
reactant: MODEL1310110059#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_27899641_459d_44e9_aed0_bb551bb67179
initial amount: NaN
boundary condition: true
has only substance units: false
name: ITPKC
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q96DU7
type: Species
is encoded by: hsa:80271

metaR DCSPTN1CPT2
reactant: MODEL1310110059#
product: MODEL1310110059#
name: carnitine transferase
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_5981fa53_6049_4ccd_8069_5e603a95f053
is: Q9Y2Q0
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:10396
has only substance units: false
is: SBO:0000252
name: ATP8A1
initial concentration: NaN

metaR r2375
reactant: MODEL1310110059#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#

metaM xoldiolone r
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false
is: CHEBI:28477
is: SBO:0000247
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: HMDB02197
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaM zym int2 r
is: CHEBI:52386
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
name: zymosterol intermediate 2
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species

metaR r0638
type: Reaction
modifier: MODEL1310110059#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.1.2
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176
reversible: true

metaM pail45p hs c
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
is: SBO:0000247
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
type: Species
initial concentration: 1.0
initial amount: NaN

metaM hs deg5 l
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
constant: false
is: SBO:0000247
name: heparan sulfate, degradation product 5
is: CHEBI:17895
has only substance units: false
boundary condition: false
is: HMDB00158

metaR RE1573M
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reversible: true
name: RE1573
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_caf2b723_24a2_4901_8749_ff64b3fb4a1b
initial concentration: NaN
is encoded by: hsa:22978
initial amount: NaN
is: P49902
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: NT5C2
constant: false

metaR r0633
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110059#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110059#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR TAUBETAtc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_69bc0574_a223_4f38_a74b_807738214253
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:30833
is: Q8TCD5
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: NT5C

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM 4abutn e
is: SBO:0000247
name: 4-ammoniobutanal
has only substance units: false
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58264
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_3a4d562a_3c6d_40fd_8a7a_53b1c9ce1965
is: O95299
initial amount: NaN
has only substance units: false
is encoded by: hsa:4705
name: NDUFA10
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_59c68619_204f_4b6b_ae85_ca19003e841a
is: SBO:0000252
is encoded by: hsa:AI924226
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: _AI924226_1_m
boundary condition: true

metaM 6dhf m
initial concentration: 1.0
is: HMDB06563
initial amount: NaN
is: SBO:0000247
type: Species
name: hexaglutamyl folate (DHF)
constant: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
boundary condition: false
has only substance units: false

metaR NADH2 u10m
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
kinetic law: MODEL1310110059#
fast: false
name: NADH dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.6.5.3
is: SBO:0000185
modifier: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.6.99.3
reactant: MODEL1310110059#

metaR r2378
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r1078
product: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110059#
name: Vesicular transport
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110059#
fast: false

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR OCD11CRNCPT2
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM ade e
is: HMDB00034
type: Species
is: CHEBI:16708
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
name: adenine
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_e49dd033_88c2_45f7_8bfb_71dea800c439
is: Q9UNP4
is: SBO:0000252
type: Species
name: ST3GAL5
is encoded by: hsa:8869
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_51661065_d875_4c0a_8480_ed4d3b71a498
name: ACLY
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:47
constant: false
has only substance units: false
boundary condition: true
type: Species

metaM 5eipencoa m
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 5,8,11,14,17-eicosapentenoylcoa
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_33c881ea_56c3_4f39_8a94_9adc16483fa9
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _T83654_1_e
type: Species
constant: false
is encoded by: hsa:T83654

http://identifiers.org/biomodels.db/MODEL1310110059#_0f6f95eb_2ec8_47bf_a83b_31e671a371ac
is encoded by: hsa:160728
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q8N695
name: SLC5A8
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r2377
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_0fcc2311_651b_4400_b089_9a9172cd4164
initial concentration: NaN
constant: false
initial amount: NaN
is: Q96SL4
type: Species
is encoded by: hsa:2882
has only substance units: false
is: SBO:0000252
boundary condition: true
name: GPX7

http://identifiers.org/biomodels.db/MODEL1310110059#_82c0dba9_49d4_4dcf_837a_adaed1e14771
initial concentration: NaN
is: SBO:0000252
name: ARSA
is: P15289
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:410
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_26354acd_e460_49eb_89e9_1a86a57f8804
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2589
name: GALNT1
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q10472
type: Species

metaR C4STMO1r
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.14.13.72
kinetic law: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_39e2f947_225b_49c6_a932_3683320cf425
initial concentration: NaN
constant: false
is: B4DUG1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SLC24A1
is encoded by: hsa:9187
has only substance units: false

metaR r1939
product: MODEL1310110059#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110059#
is: SBO:0000185
reversible: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR FAOXC10C8m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

metaR IDOURtly
fast: false
modifier: MODEL1310110059#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: iduronate transport into lysososme
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
reactant: MODEL1310110059#
product: MODEL1310110059#

metaM taur x
is: CHEBI:15891
is: HMDB00251
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
initial amount: NaN
type: Species
name: taurine
has only substance units: false
constant: false

metaM peamn c
constant: false
name: 2-phenylethanaminium
has only substance units: false
type: Species
is: HMDB12275
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:225237
boundary condition: false

metaR SUBERICACT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_38c5bcf1_1c42_43cc_9fdc_aa0486a05385
type: Species
boundary condition: true
is: SBO:0000252
is: P05062
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:229
initial concentration: NaN
name: ALDOB

metaM ksi e
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial concentration: 1.0
is: HMDB00211
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:17268
name: keratan sulfate I
is: SBO:0000247

metaR MI145PP
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.3.56
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000269
product: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86
name: inositol-1,4,5-trisphosphate 5-phosphatase
reactant: MODEL1310110059#

metaR r0634
type: Reaction
product: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_6704121a_59fc_414f_8e33_70793d597548
is: P47895
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:220
constant: false
name: ALDH1A3
initial amount: NaN
initial concentration: NaN
type: Species

metaR GLUVESSEC
is: SBO:0000185
notes: GENE_ASSOCIATION: (57084.1) or (246213.1) or (57030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11432869,PMID:12811560,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known stoichiometrically.
is described by: ECO:0000269
product: MODEL1310110059#
fast: false
name: L-glutamate secretion via secretory vesicle (ATP driven)
modifier: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
type: Reaction

metaR r2379
reactant: MODEL1310110059#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_790722bc_9aa3_420f_8e6a_2ffc90f884b5
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: A8K0T6
constant: false
is: SBO:0000252
initial concentration: NaN
name: SMPD3
is encoded by: hsa:55512

metaR G14T20g
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000

metaM 6dhf l
boundary condition: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
name: hexaglutamyl folate (DHF)
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB06563

metaR r0339
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reversible: false
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
type: Reaction
reactant: MODEL1310110059#

metaR FE3MTP1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000134
name: transport of ferrous iron into blood
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
modifier: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false

metaR r0407
fast: false
modifier: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is version of: http://identifiers.org/ec-code/1.4.3.5
reactant: MODEL1310110059#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_01a51f83_3804_460b_a3bf_b81f2e3b0599
type: Species
is encoded by: hsa:100287639
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _100287639_1_c

http://identifiers.org/biomodels.db/MODEL1310110059#_44d46c61_66ca_4e18_8a7e_88c78146dc8e
initial amount: NaN
type: Species
is: SBO:0000252
name: ME3
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:10873
is: Q6TCH8
initial concentration: NaN

metaR CYTK7
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110059#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
name: cytidylate kinase (CMP,UTP)

http://identifiers.org/biomodels.db/MODEL1310110059#_a90421ca_ece4_42b7_b4e6_557638800a6b
name: ENPP3
is: Q308M7
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:5169
boundary condition: true
constant: false
initial concentration: NaN

metaR UMPK7
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
name: UMP kinase (dGTP)
is: SBO:0000176
reversible: true

metaR DINt
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoxyinosine transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
reversible: true
fast: false
product: MODEL1310110059#
type: Reaction

metaM HC00342 m
name: cis-aconitate(3-)
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: CHEBI:16383

metaM CE2417 m
constant: false
is: HMDB11123
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28387
is: SBO:0000247
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
type: Species
boundary condition: false
has only substance units: false

metaR Q10H2e
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
is: SBO:0000185
reversible: true
name: transport of ubiquinol into lymph
is described by: ECO:0000134
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_118795c6_e42e_4527_bd7b_2b82cdbb940c
is: B3KVI7
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:3712
is: SBO:0000252
boundary condition: true
name: IVD
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_a2c0c08b_28ae_4565_b051_4a99f0fc9631
is: Q7GXZ4
initial concentration: NaN
name: ND4L
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4539
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_1b26d3ab_8344_4d06_8d19_698f73cb22cf
type: Species
is encoded by: hsa:400410
initial amount: NaN
name: ST20
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9HBF5
is: SBO:0000252
constant: false

metaM ksi pre2 g
is: HMDB00175
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 2
type: Species
is: C00130
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaM phyt e
is: CHEBI:37257
constant: false
has only substance units: false
type: Species
name: phytanate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
initial amount: NaN
boundary condition: false
is: HMDB00801
initial concentration: 1.0
is: SBO:0000247

metaR CYTK8
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110059#
name: cytidylate kinase (CMP,dATP)
reversible: true
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0789
type: Reaction
kinetic law: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
reactant: MODEL1310110059#

metaR AG13T9g
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
fast: false
reversible: false
product: MODEL1310110059#

metaR BALAtmr
reactant: MODEL1310110059#
name: Beta-alanine reversible mitochondrial transport (diffusion)
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is described by: ECO:0000000
type: Reaction
reversible: true

metaR DM gpi sig er
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_1a58a9bb_9bf6_444d_bf2f_ac2a6e8c87e7
name: _AI684467_1_m
initial concentration: NaN
is encoded by: hsa:AI684467
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false

metaR S6T10g
reversible: false
is: SBO:0000176
product: MODEL1310110059#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false

metaR FAOXC181C161m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR PPCOAOm
kinetic law: MODEL1310110059#
reversible: false
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
modifier: MODEL1310110059#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial

metaM 5pmev x
type: Species
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
is: CHEBI:58146
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01343
is: SBO:0000247
constant: false
boundary condition: false
name: (R)-5-phosphonatomevalonate(3-)

metaR PRODt2r
is: SBO:0000185
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
reversible: true
modifier: MODEL1310110059#
name: D-proline reversible transport via proton symport

metaM ksi pre14 g
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:28067
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 14

http://identifiers.org/biomodels.db/MODEL1310110059#_3446ede9_8296_44fd_abc0_e3e43d83f207
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:D87002
is: SBO:0000252
name: _D87002_1_m
type: Species
has only substance units: false

metaM co e
is: HMDB01361
constant: false
is: SBO:0000247
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:17245
name: carbon monoxide

metaR GUACYC
is: SBO:0000176
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.6.1.2
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
is described by: ECO:0000269
name: guanylate cyclase
product: MODEL1310110059#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_46723037_7bef_4b13_9be9_294224fedd08
has only substance units: false
name: NT5C1B
is: SBO:0000252
boundary condition: true
is encoded by: hsa:93034
initial concentration: NaN
is: Q96P26
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_9f9320c5_44dc_4b96_8b01_c1a26140f96b
boundary condition: true
initial concentration: NaN
is: P48735
name: IDH2
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:3418
constant: false

metaR CYTK4
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110059#
name: cytidylate kinase (dCMP)(GTP)
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
kinetic law: MODEL1310110059#
is: SBO:0000176
reversible: true
type: Reaction

metaR DOPASFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
reversible: false
is: SBO:0000185
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
fast: false
name: Dopamine 3-0-sulfate transport (diffusion)
type: Reaction
kinetic law: MODEL1310110059#

metaM uppg3 c
is: SBO:0000247
type: Species
constant: false
is: C01051
is: CHEBI:57308
initial amount: NaN
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
boundary condition: false
is: HMDB01086
initial concentration: 1.0
name: Uroporphyrinogen III
has only substance units: false

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM fald c
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16842
has only substance units: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
initial amount: NaN
is: HMDB01426
name: formaldehyde

metaR FAOXC123m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR OLEICFATPtc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR r0408
is described by: ECO:0000000
modifier: MODEL1310110059#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
type: Reaction
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaM xylt c
initial amount: NaN
initial concentration: 1.0
name: xylitol
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17151
is: HMDB02917

metaM phyt c
is: CHEBI:37257
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
has only substance units: false
is: HMDB00801
initial amount: NaN
is: SBO:0000247
name: phytanate
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

metaR CYTK6
type: Reaction
kinetic law: MODEL1310110059#
fast: false
name: cytidylate kinase (CMP,CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110059#_940fa8d5_179c_42ea_ab8a_182c13180aa7
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: PDE9A
initial concentration: NaN
is encoded by: hsa:5152

metaR ADK1
is: SBO:0000176
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
name: adenylate kinase
type: Reaction
reactant: MODEL1310110059#

metaR EX 34hpp
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM pglyc hs c
boundary condition: false
has only substance units: false
is: CHEBI:21338
type: Species
notes: FORMULA: CHARGE: 0
initial amount: NaN
constant: false
name: pglyc_hs[c]
is: SBO:0000247
initial concentration: 1.0
is: HMDB02704

metaR CYTK5
modifier: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
reversible: true
name: cytidylate kinase (dCMP)
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR FAS180COA
is: SBO:0000176
reversible: false
modifier: MODEL1310110059#
product: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C18:0CoA)
is described by: ECO:0000269
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction
reactant: MODEL1310110059#

metaR UGALGTg
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
modifier: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
fast: false

metaM hs deg17 l
name: heparan sulfate, degradation product 17
is: SBO:0000247
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: CHEBI:21338
initial amount: NaN
constant: false
has only substance units: false
is: HMDB02704
boundary condition: false
type: Species
initial concentration: 1.0

metaR r2086
type: Reaction
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110059#

metaR HIVCRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_bd708b37_ffa5_4a08_bd1a_c0293e0afead
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7991
constant: false
initial amount: NaN
is: Q13454
is: SBO:0000252
name: TUSC3

http://identifiers.org/biomodels.db/MODEL1310110059#_37061342_c374_4bd9_9915_2bb163b1f9c3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1120
name: CHKB
is: A0PJM6
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_9858319f_4210_4e25_a40f_c840cd3dca2f
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1384
name: CRAT

http://identifiers.org/biomodels.db/MODEL1310110059#_52ba0688_a58b_45de_a40a_9c47d9c8a858
initial amount: NaN
has only substance units: false
is: P54750
initial concentration: NaN
is encoded by: hsa:5136
type: Species
constant: false
boundary condition: true
name: PDE1A
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_731e93ce_7b69_497d_825c_3ebe0b7b9f52
type: Species
is: G3V0F6
constant: false
name: DGKZ
is encoded by: hsa:8525
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR FUMtm
reversible: true
modifier: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110059#
name: fumarate transport, mitochondrial

metaM 3hexdtricoa x
has only substance units: false
type: Species
is: HMDB02288
initial amount: NaN
is: SBO:0000247
name: 3,7,10-hexadecatrienoylcoa
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaR RE2649C
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.2.2
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reversible: true
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: RE2649
product: MODEL1310110059#
is: SBO:0000176

metaR NACHEXA21ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110059#
reversible: false
fast: false
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaM 4abutn m
constant: false
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
is: SBO:0000247
is: CHEBI:58264
initial concentration: 1.0
is: HMDB01080
type: Species
name: 4-ammoniobutanal
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_09df38c7_3dd0_4de4_9b3f_d989204be0b1
is: Q9Y6L6
type: Species
initial concentration: NaN
boundary condition: true
name: SLCO1B1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:10599
constant: false

metaR r2087
fast: false
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110059#
product: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_b5a60f60_82f2_44f6_b41b_6ab64a8b5b84
name: SDHD
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: O14521
boundary condition: true
is encoded by: hsa:6392
is: SBO:0000252

metaR FAOXC18480m
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is: SBO:0000176
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000

metaM tetpent3 c
name: tetracosapentaenoic acid, n-3
boundary condition: false
initial concentration: 1.0
is: HMDB06323
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110059#_e3215fd4_9d72_4be8_ae23_220465f91f1b
constant: false
initial concentration: NaN
is encoded by: hsa:5287
is: O00750
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: PIK3C2B
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_703e5752_defb_40b8_9d74_0ccf935f1d22
is: P19623
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: SRM
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6723

metaM sphgn c
boundary condition: false
is: CHEBI:57817
name: sphinganine(1+)
is: HMDB00269
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
has only substance units: false

metaM ipdp x
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01347
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: CHEBI:128769
type: Species
name: isopentenyl diphosphate(3-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_95ba74ec_e6f9_4e0c_bf7b_856c732c182e
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4669
initial amount: NaN
is: P54802
type: Species
constant: false
name: NAGLU

metaM ksi l
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
constant: false
initial amount: NaN
has only substance units: false
is: C00445
is: HMDB01354
is: SBO:0000247
is: CHEBI:57455
type: Species

metaR r2088
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000185
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_166199cf_1dea_43c3_9f25_6186083ed34b
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:X63359
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _X63359_1_c

metaR CYTK9
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP)
reactant: MODEL1310110059#
fast: false
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110059#
type: Reaction
product: MODEL1310110059#

metaR r2372
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true

metaR SERGLNexR
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
name: L-Serine/Glutamine reversible exchange
reactant: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000304

metaR TYRTA
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000176
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110059#
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110059#
fast: false

metaR FAOXC165C164x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaM cytd m
is: CHEBI:17562
name: cytidine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
type: Species
is: HMDB00089
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_236ee07e_032c_41f5_bd3a_c43f4b7c4928
constant: false
name: FOLR1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:2348

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM tethex3coa x
name: tetracosahexaenoyl coenzyme A
boundary condition: false
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205478
initial concentration: 1.0
is: C16168
is: SBO:0000247
is: HMDB06243
type: Species
has only substance units: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR GGH 6THFl
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110059#
name: Gamma-glutamyl hydrolase (6THF), lysosomal
reversible: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_61bbf7b9_b786_4a24_a184_512a91126ea5
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: D3DX95
is encoded by: hsa:1103
name: CHAT

metaR r2371
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110059#

metaR ALASm
kinetic law: MODEL1310110059#
name: 5-aminolevulinate synthase
product: MODEL1310110059#
is described by: ECO:0000254
type: Reaction
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.37
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.29
reactant: MODEL1310110059#
reversible: false
fast: false

metaR BDMT L
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
reversible: false
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.142
fast: false
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)

metaM fpram c
constant: false
type: Species
is: CHEBI:58478
is: HMDB06211
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
is: C04640

metaM tetpent3 e
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
name: tetracosapentaenoic acid, n-3
initial concentration: 1.0
type: Species
is: HMDB06323
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaR r2089
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110059#
reversible: true
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM ru5p D c
boundary condition: false
is: HMDB00618
name: D-ribulose 5-phosphate(2-)
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

metaR NRPPHRSFt
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
is: SBO:0000185
type: Reaction
name: norepinephrine sulfate transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110059#_a7b329e1_3629_45e1_b6c7_a6ad7012c291
constant: false
is: P49247
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: RPIA
type: Species
is encoded by: hsa:22934
initial amount: NaN

metaM Ser Gly Ala X Gly l
type: Species
is: HMDB02183
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:36005
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine residue (glycosaminoglycan attachment site)

http://identifiers.org/biomodels.db/MODEL1310110059#_ea558f9d_d30f_43bd_8c2f_2491610b4aa6
is encoded by: hsa:84649
has only substance units: false
is: Q96PD7
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: DGAT2
boundary condition: true
type: Species
constant: false

metaR CITRtm
reversible: true
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: citrulline mitochondrial transport via proton antiport
kinetic law: MODEL1310110059#

metaR NACHEX9ly
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_0f77c29c_1fc3_4021_9f51_952215f0c969
initial amount: NaN
name: PROSC
constant: false
is: SBO:0000252
is: O94903
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:11212

http://identifiers.org/biomodels.db/MODEL1310110059#_28b6adfa_6dad_43f0_915c_0dee4abc28a0
constant: false
boundary condition: true
name: ASRGL1
is: Q7L266
initial amount: NaN
is encoded by: hsa:80150
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR SFGTH
name: S-Formylglutathione hydralase
is version of: http://identifiers.org/ec-code/3.1.2.12
modifier: MODEL1310110059#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110059#
fast: false
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD

metaR TRDR2
product: MODEL1310110059#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (7296.1) or (7296.4) or (7296.2) or (7296.3) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:12435734,PMID:8577704,PMID:8999974 NOTES:Xia et al, 2003, JBC, 2141-2146
name: Thioredoxin (ubiquinone 10) reductase (NADPH)
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110059#
fast: false
type: Reaction

metaR CYSTHRNaEx
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: false
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110059#
is described by: ECO:0000269
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)

metaM dcsptn1coa x
is: HMDB06513
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0
boundary condition: false
is: C16173
initial amount: NaN
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
constant: false
type: Species

metaR GASNASE3ly
reversible: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.5.1.26
name: glycosylasparaginase, lysosomal
is: SBO:0000176
reactant: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
type: Reaction
fast: false

metaR FAOXC80
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
fast: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110059#
name: Beta oxidation of med/long chain fatty acid
product: MODEL1310110059#

metaR CO2tm
is described by: ECO:0000000
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110059#
name: CO2 transport (diffusion), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_4e48aa86_e8ad_41d9_849a_1b3abcf6bf7b
is encoded by: hsa:5208
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PFKFB2
is: SBO:0000252
is: O60825
constant: false
type: Species
has only substance units: false

metaM CE5126 x
name: (2R)-pristanoyl-CoA
is: CHEBI:15748
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00127
boundary condition: false
constant: false

metaM 3hibutcoa m
is: CHEBI:28259
boundary condition: false
initial concentration: 1.0
is: HMDB01052
constant: false
is: SBO:0000247
initial amount: NaN
name: (S)-3-Hydroxyisobutyryl-CoA
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_2c07d33e_fd6f_42a6_b069_031172395fba
type: Species
is: SBO:0000252
is: P56381
has only substance units: false
constant: false
name: ATP5E
is encoded by: hsa:514
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR HSD3A1r
reactant: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110059#
fast: false
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110059#
reversible: true

metaM imp e
is: CHEBI:58053
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00175
is: SBO:0000247
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial concentration: 1.0
name: IMP(2-)
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_6cbdba74_daf1_4425_abb3_bf8fff864f31
is: Q05932
type: Species
initial amount: NaN
name: FPGS
is encoded by: hsa:2356
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaR r1721
kinetic law: MODEL1310110059#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110059#
is: SBO:0000185
reactant: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_2ffb3633_ddd6_4d4d_9a34_4ef4db1a4bdb
boundary condition: true
is encoded by: hsa:54363
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q9UJM8
name: HAO1
has only substance units: false

metaM dgchol e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00637
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
constant: false
type: Species
has only substance units: false
name: glycochenodeoxycholate

metaR FAOXC10C8x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM ptdca e
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
name: pentadecanoate
is: http://identifiers.org/pubchem.compound/22169126
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: HMDB00826

metaR FAOXC2252053m
type: Reaction
reversible: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
modifier: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
name: Beta oxidation of long chain fatty acid

metaM prostgh2 c
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
type: Species
is: HMDB01381
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: prostaglandin H2(1-)
is: CHEBI:57405

http://identifiers.org/biomodels.db/MODEL1310110059#_8e0d33d4_7432_49f9_b6b5_21dc6e9c1ba3
initial amount: NaN
is encoded by: hsa:53354
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PANK1
initial concentration: NaN
type: Species

metaR r0998
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185
reversible: true
type: Reaction
name: Facilitated diffusion
fast: false
is described by: ECO:0000000

metaM HC00342 c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
name: cis-aconitate(3-)
constant: false
type: Species
boundary condition: false

metaM ksi deg13 l
boundary condition: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 13
initial amount: NaN
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
is: CHEBI:16953
initial concentration: 1.0
is: HMDB00812
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_63c42070_7d49_48b0_af3a_c2055b8ecc72
constant: false
is: Q02742
name: GCNT1
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2650
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM ksi deg5 l
is: HMDB00143
is: CHEBI:12936
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: SBO:0000247
type: Species
constant: false
name: keratan sulfate I, degradation product 5
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false

metaR r0410
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110059#

metaR 4NPHte
reversible: true
name: xenobiotic transport
product: MODEL1310110059#
fast: false
is: SBO:0000185
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat

metaR r0995
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_6656a3b3_a888_48a7_95bc_b2117d38e47e
type: Species
has only substance units: false
is: Q92820
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8836
constant: false
initial amount: NaN
name: GGH

metaM air c
has only substance units: false
is: HMDB01235
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C03373
is: CHEBI:58592
initial amount: NaN
constant: false

metaR RE0583C
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
name: RE0583
type: Reaction
reactant: MODEL1310110059#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_eef3d377_016d_48b6_802b_060dcfb433f2
is encoded by: hsa:5291
is encoded by: hsa:5295
name: PIK3CB:PIK3R1
constant: false
has only substance units: false
boundary condition: true
has part: B3KT19
initial amount: NaN
type: Species
initial concentration: NaN
has part: B4DER4
is: SBO:0000297

metaM lnlccoa m
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
initial amount: NaN
is: SBO:0000247
name: linoleic coenzyme A
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983

http://identifiers.org/biomodels.db/MODEL1310110059#_3ab1780c_769b_419f_aaa8_48916c491ae9
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SCD
boundary condition: true
is: O00767
constant: false
is: SBO:0000252
is encoded by: hsa:6319

metaR GLCNACASE1ly
product: MODEL1310110059#
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_b0e2799f_e71c_4da3_b9d4_314f8c65be81
constant: false
boundary condition: true
has part: P13804
is: SBO:0000297
is encoded by: hsa:2108
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:2109
name: ETFA:ETFB
has only substance units: false

metaR FAOXC3DC
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaM pdx5p c
has only substance units: false
constant: false
is: CHEBI:58589
is: SBO:0000247
name: Pyridoxine 5'-phosphate
boundary condition: false
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
initial concentration: 1.0
type: Species
is: HMDB01319
is: C00627
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_b72c3561_da46_45e6_af3f_7cae5d221511
is encoded by: hsa:AA629629
name: _AA629629_1_m
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

metaM omhpal c
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C16H30O3 CHARGE: -1
is: HMDB06294
constant: false
name: w-hydroxypalmiticacid
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_76de3a72_a7a2_4c4b_8e6b_bd191e0ff32e
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: Q06830
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:5052
name: PRDX1

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM ptdca c
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
name: pentadecanoate
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/22169126
type: Species
constant: false
is: HMDB00826

metaR TAGt
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
name: triacylglycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

metaM dgchol c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
has only substance units: false
type: Species
is: CHEBI:36252
constant: false
name: glycochenodeoxycholate
boundary condition: false
initial concentration: 1.0

metaR NDPK4n
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
is: SBO:0000176
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR SGALSIDEtl
type: Reaction
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
name: sgalside hs intracellular transport
product: MODEL1310110059#
reversible: true

metaM 3ddecdicoa m
is: SBO:0000247
name: 3,6-dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: C05280
is: HMDB03952
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_76a8e86c_14d1_43a6_be60_7bc1affec7ca
is encoded by: hsa:NM 001929
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _NM_001929_1_c

http://identifiers.org/biomodels.db/MODEL1310110059#_7df12059_65fe_429c_92db_61dd8236852f
is: P30837
boundary condition: true
is: SBO:0000252
name: ALDH1B1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:219
has only substance units: false
type: Species
constant: false

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: Gamma-glutamyltransferase
reversible: true
fast: false
is: SBO:0000176

metaR AG13T8g
kinetic law: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_9a1dfc08_29ae_4e48_bd2c_3c7d8d5ae819
boundary condition: true
name: ACP1
type: Species
is: Q59EH3
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:52
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_3224147b_2744_4a09_87ad_0e5196bf5879
type: Species
constant: false
boundary condition: true
is: Q13011
name: ECH1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1891
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_fb1bf0fb_fa5d_4908_8aa1_10fb23ece8b1
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:622
type: Species
initial concentration: NaN
name: BDH1
is: SBO:0000252
initial amount: NaN

metaM melatn c
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
name: melatonin
is: HMDB01389
is: CHEBI:16796
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR S4TASE5ly
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: true
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_d3a7014b_6972_4b8a_97cf_7edc1a45f129
constant: false
has only substance units: false
type: Species
is: Q8TDY1
initial amount: NaN
is encoded by: hsa:8706
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: B3GALNT1

metaM akg c
is: C00026
type: Species
is: HMDB00208
is: SBO:0000247
initial concentration: 1.0
name: 2-Oxoglutarate
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
constant: false
is: CHEBI:16810
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_9af37e5f_ea92_49fc_a620_92f99c7b1ad0
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: ALPP
initial amount: NaN
is: P05187
is: SBO:0000252
has only substance units: false
is encoded by: hsa:250

metaR HOCDACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR TSTSTERONEt
reversible: true
reactant: MODEL1310110059#
fast: false
is: SBO:0000185
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
name: Testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110059#_52368d9d_5f20_44dc_bdba_bf6dcade3661
is: C9JPQ8
is encoded by: hsa:5095
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: PCCA
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_2faec6c3_473d_4d89_8c4c_50d3997dcc42
name: RHAG
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6005
has only substance units: false
is: Q96E98
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_de28b65b_d760_4850_b0fc_c8831e1e6ec7
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:7390
name: UROS
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: P10746

metaR L LACt2r
modifier: MODEL1310110059#
fast: false
is described by: ECO:0000269
name: L-lactate reversible transport via proton symport
kinetic law: MODEL1310110059#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_4316a3ec_562d_4883_8d50_cb99fa0ee25d
type: Species
boundary condition: true
has only substance units: false
name: _J03866_1_m
is: SBO:0000252
constant: false
is encoded by: hsa:J03866
initial concentration: NaN
initial amount: NaN

metaM CE5118 m
constant: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
is: CHEBI:57923
is: SBO:0000247

metaR SERtN1
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
product: MODEL1310110059#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000185
reactant: MODEL1310110059#
name: Serine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110059#_8a45364f_d608_4d94_b23f_9cfc3b4f14d4
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: PIGO
is encoded by: hsa:84720

http://identifiers.org/biomodels.db/MODEL1310110059#_db609c36_9111_4083_b16d_7835b25ffaae
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:2595
name: GANC
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: Q8TET4

metaM pheme m
type: Species
is: C00032
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:17627
name: Protoheme
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: SBO:0000247
is: HMDB03178
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ad1b4b23_c655_476f_b5cc_6e5c3805d141
is encoded by: hsa:T83654
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: _T83654_1_c
constant: false
has only substance units: false

metaR r1725
reversible: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false

metaR CO2tp
reversible: true
type: Reaction
is: SBO:0000185
name: CO2 peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000

metaR S6T12g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000176
reversible: false

metaR FAOXC204184m
modifier: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
kinetic law: MODEL1310110059#

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaR ACP1 FMN
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000254
fast: false
reactant: MODEL1310110059#
name: acid phosphatase (FMN)
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
type: Reaction
is: SBO:0000176
reversible: false

metaM akg e
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
type: Species
name: 2-oxoglutarate(2-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16810
is: HMDB00208

http://identifiers.org/biomodels.db/MODEL1310110059#_b0e71a82_6ac3_471c_8bbf_d5801f30ab0a
initial concentration: NaN
type: Species
is encoded by: hsa:203
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: AK1
has only substance units: false
is: P00568
constant: false

metaM imp c
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00130
has only substance units: false
name: IMP
initial concentration: 1.0
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
type: Species
is: CHEBI:58053
is: HMDB00175
constant: false

metaM 5aop m
initial concentration: 1.0
is: C00430
is: CHEBI:17549
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
constant: false
is: HMDB01149
name: 5-Amino-4-oxopentanoate
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_3b8bb58d_da42_41bc_b620_e568dcb9843b
is: P48735
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3418
initial amount: NaN
constant: false
name: IDH2
is: SBO:0000252
boundary condition: true

metaR SGALSIDEtg
kinetic law: MODEL1310110059#
name: sgalside hs intracellular transport
product: MODEL1310110059#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR GGH 6THFe
product: MODEL1310110059#
name: Gamma-glutamyl hydrolase (6THF), extracellular
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176

metaR r0999
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110059#
fast: false
name: Facilitated diffusion
reversible: true
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_d135b001_c822_427a_9e9a_7e191b44ec4a
name: _D87002_1_e
has only substance units: false
initial concentration: NaN
is encoded by: hsa:D87002
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_88221152_3848_4886_9b80_89db118f8ce2
is: SBO:0000252
is: P22352
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2878
name: GPX3

metaM glyc c
name: Glycerol
is: C00116
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
initial amount: NaN
boundary condition: false
is: CHEBI:17754

metaR S6TASE19ly
modifier: MODEL1310110059#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
kinetic law: MODEL1310110059#

metaM pe hs e
constant: false
is: SBO:0000247
boundary condition: false
name: phosphatidylethanolamine
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

metaM glyc e
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:17754
is: C00116
is: HMDB00131
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_35b66863_2b02_43a7_8106_c4163f53e499
has part: P06576
has only substance units: false
initial concentration: NaN
boundary condition: true
has part: A8K092
is encoded by: hsa:498
type: Species
has part: P36542
is: SBO:0000297
has part: P30049
is encoded by: hsa:509
has part: P56381
constant: false
is encoded by: hsa:514
initial amount: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:506
is encoded by: hsa:513

metaR DAGt
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110059#
name: diacylglycerol transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_ccce3cad_5a1e_48af_99ee_1a4f7978fb8b
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:506
is: P06576
name: ATP5B
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaM ksii core2 pre6 g
notes: FORMULA: C61H98N5O46SX CHARGE: -2
initial concentration: 1.0
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false

metaR r0774
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
product: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_8fa7321d_0a27_4916_812b_8b56136e00a7
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: TUSC3
is encoded by: hsa:7991
initial amount: NaN
boundary condition: true

metaR r0560
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
is: SBO:0000176
type: Reaction
reversible: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_b1c6e9c4_3457_4547_a55d_bbf030f604bc
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:93010
type: Species
constant: false
boundary condition: true
name: B3GNT7
has only substance units: false
is: Q8NFL0

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_11abd43c_013c_485b_8f62_0fc8fe32d587
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:124
is: P07327
type: Species
initial concentration: NaN
is: SBO:0000252
name: ADH1A
constant: false

metaR PIPLC
fast: false
product: MODEL1310110059#
reversible: false
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176
name: phosphatidylinositol phospholipase C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.4.11

metaM glu L l
constant: false
name: L-glutamate(1-)
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
is: HMDB00148
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_81c41699_d693_4e89_9fde_41206ce6d353
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:1807
has only substance units: false
type: Species
name: DPYS
initial concentration: NaN
is: SBO:0000252
is: Q14117

metaM core2 g
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: Core 2
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:15876

http://identifiers.org/biomodels.db/MODEL1310110059#_e9b4966f_d7d0_44ff_8823_8ab8655a00bc
has only substance units: false
type: Species
is encoded by: hsa:29085
boundary condition: true
is: Q9P019
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: PHPT1

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM pail45p hs m
boundary condition: false
type: Species
name: phosphatidylinositol 4,5-bisphosphate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28910
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_24fb15d0_6117_490b_a653_6587fcd092b3
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: ATP5E
is encoded by: hsa:514

metaR CBASPte
fast: false
is: SBO:0000185
kinetic law: MODEL1310110059#
name: Transport of N-carbamoyl-L-aspartate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
is described by: ECO:0000134

metaR r2359
type: Reaction
product: MODEL1310110059#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaR PCm
reversible: false
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
is version of: http://identifiers.org/ec-code/6.4.1.1
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176
name: pyruvate carboxylase
type: Reaction
reactant: MODEL1310110059#

metaR NDPK4
modifier: MODEL1310110059#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:dTDP)
product: MODEL1310110059#
fast: false
type: Reaction
reactant: MODEL1310110059#

metaM fn2m2masn g
initial concentration: 1.0
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
boundary condition: false
constant: false
is: CHEBI:32984
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species

metaR C142ACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR FAOXC165C164m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a125af91_6e83_48ab_97a7_a029417411cb
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:22305
name: _22305_2_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR PI45PLC
reversible: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
fast: false
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
product: MODEL1310110059#
type: Reaction

metaM bilirub c
initial concentration: 1.0
initial amount: NaN
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: bilirubin(2-)
is: CHEBI:57977
constant: false

metaM glu L m
is: SBO:0000247
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
constant: false
is: HMDB00148
name: L-glutamate(1-)
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_8d3ebb80_a8db_4936_9029_ad8cf8c2a615
initial concentration: NaN
is encoded by: hsa:762
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: Q6FHI7
has only substance units: false
name: CA4

metaR FAOXC121x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaM 4abutn c
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
is: C00555
is: HMDB01080
initial concentration: 1.0
has only substance units: false
type: Species
name: 4-Aminobutanal
boundary condition: false
constant: false
initial amount: NaN

metaM pail45p hs n
name: phosphatidylinositol 4,5-bisphosphate
type: Species
is: CHEBI:28910
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false

metaM lnlncg e
is: CHEBI:32391
has only substance units: false
is: SBO:0000247
is: HMDB03073
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
type: Species
constant: false
name: gamma-linolenate
initial amount: NaN
initial concentration: 1.0

metaR ECOAH12m
kinetic law: MODEL1310110059#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
product: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM 3ddecdicoa x
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: SBO:0000247
name: 3,6-dodecadienoylcoa
type: Species
is: HMDB03952
initial amount: NaN
initial concentration: 1.0
is: C05280
boundary condition: false

metaR NDPK5
fast: false
name: Nucleoside-diphosphate kinase (ATP:dGDP)
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
is: SBO:0000176
product: MODEL1310110059#

metaR HS3ly
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
name: heparan-N-sulfatase, lysosomal
reactant: MODEL1310110059#
reversible: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.10.1.1
modifier: MODEL1310110059#

metaM pe hs c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false
name: phosphatidylethanolamine
type: Species
boundary condition: false

metaR 4NPHSFte
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
type: Reaction
reactant: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
name: xenobiotic transport

http://identifiers.org/biomodels.db/MODEL1310110059#_9c06106e_81f6_409b_ae1f_228a0f9f421e
boundary condition: true
initial amount: NaN
name: ACAT2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:39
type: Species
is: SBO:0000252
is: Q9BWD1
constant: false

metaR r2357
product: MODEL1310110059#
type: Reaction
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true

metaR NDPK2
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:UDP)
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_4027a65f_e767_483f_ac14_49654bb2af88
is encoded by: hsa:10195
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: ALG3
boundary condition: true

metaR EX c16dc
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_e7515acf_420c_46f4_9e18_5abd46a4aebe
has part: F8W7V3
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:517
constant: false
initial amount: NaN
is encoded by: hsa:9551
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
type: Species
has only substance units: false
boundary condition: true

metaR H2Ot
name: H2O transport via diffusion
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110059#
fast: false
reversible: true
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_4567a80f_6836_4856_a6fe_3fde064fccab
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:522
is: Q6NZ59
initial amount: NaN
name: ATP5J
is: SBO:0000252

metaR r0842
reactant: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
name: Postulated transport reaction
modifier: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_883904ea_99bf_494f_a1d7_15f3999778a4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: GCAT
type: Species
is encoded by: hsa:23464
is: E2QC23

metaR OCTAt
name: Octanoate transport via diffusion
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110059#
fast: false
type: Reaction
kinetic law: MODEL1310110059#

metaR NACHEX2ly
reversible: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176

metaR GGH 7THFe
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (7THF), extracellular
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110059#

metaR r2358
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_35ebe472_102f_422b_b335_5ad2826e746f
initial concentration: NaN
has only substance units: false
name: ACSL6
constant: false
initial amount: NaN
boundary condition: true
is: B2RB13
is: SBO:0000252
is encoded by: hsa:23305
type: Species

metaM dcsptn1coa m
boundary condition: false
is: SBO:0000247
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/47205483
is: HMDB06513
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

metaR NDPK3
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110059#
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110059#
name: nucleoside-diphosphate kinase (ATP:CDP)

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM no e
boundary condition: false
is: CHEBI:16480
type: Species
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN
is: C00533
is: HMDB03378
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

metaR NAt
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
product: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
name: sodium transport (uniport)
reversible: true
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_ba63a20a_c315_49c4_8638_e17f42b435be
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:23563
has only substance units: false
is: Q9GZS9
is: SBO:0000252
name: CHST5

metaR RE1447N
name: RE1447
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false

metaR PETOHMr hs
modifier: MODEL1310110059#
name: phosphatidylethanolamine N-methyltransferase
is: SBO:0000176
reactant: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.1.1.17
is described by: ECO:0000254
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ

metaM pheme e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: CHEBI:17627
type: Species
name: Protoheme
boundary condition: false
is: C00032
is: SBO:0000247
is: HMDB03178
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_4b96bf98_2d6d_4f29_a47a_8c0c49222e07
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: B4DPV0
is encoded by: hsa:5236
is: SBO:0000252
name: PGM1
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_45163fae_596a_451f_b718_76a15140d33f
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:81031
boundary condition: true
is: O95528
constant: false
type: Species
has only substance units: false
name: SLC2A10

metaR GHMT2rm
type: Reaction
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
modifier: MODEL1310110059#
product: MODEL1310110059#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110059#
is: SBO:0000176
name: glycine hydroxymethyltransferase, reversible, mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.1
reversible: true

metaM glyb e
constant: false
name: glycine betaine
is: HMDB00043
is: SBO:0000247
is: CHEBI:17750
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaR FAOXC15C13m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR r0840
reversible: true
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
kinetic law: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
fast: false
name: Free diffusion
is version of: http://identifiers.org/ec-code/1.14.13.70

metaR NAtx
name: sodium transport via diffusion (perioxisome)
is: SBO:0000185
kinetic law: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
reversible: true
reactant: MODEL1310110059#

metaR ORNt3m
is: SBO:0000185
product: MODEL1310110059#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: ornithine mitochondrial transport via proton antiport
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000269
kinetic law: MODEL1310110059#

metaR BUTt2r
is: SBO:0000185
kinetic law: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
modifier: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
name: Butyrate transport via proton symport, reversible
type: Reaction

metaR FADtru
is described by: ECO:0000000
name: FAD transporter, endoplasmic reticulum
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

metaM ascb L c
name: L-ascorbate
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
is: CHEBI:38290
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR 2AMACSULT
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220,PMID:6351723 NOTES:-this is a lumped rxn w/ an inferred reduction rxn that occurs in conjunction w/ sulfotransferase step; this reduction step has to occur in order for the transformation (2amac-->Lcyst) to be valid -used NADPH as electron donor since it is a common cofactor involved in biosynthetic steps utilizing oxygen (see Neema for further explanations) MM
reversible: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: 2-Aminoacrylate sulfotransferase
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR RE0383C
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
product: MODEL1310110059#
name: RE0383
modifier: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000000

metaR O2t
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
kinetic law: MODEL1310110059#
reversible: true
name: o2 transport (diffusion)
reactant: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction

metaM g6p c
is: C00092
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61548
name: D-Glucose 6-phosphate
is: HMDB01401

metaM CE2432 m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57795
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
type: Species
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
constant: false

metaM eicostetcrn m
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
is: CHEBI:57312
is: HMDB01356
is: SBO:0000247
name: Eicosatetranoyl carnitine
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM lanost r
has only substance units: false
initial concentration: 1.0
is: CHEBI:16521
is: SBO:0000247
is: HMDB01251
name: lanosterol
boundary condition: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724

metaM n2m2nmasn e
boundary condition: false
is: C04946
initial amount: NaN
type: Species
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false
is: SBO:0000247
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
has only substance units: false
initial concentration: 1.0

metaR DHEASULT
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.4
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
name: Dehydroepiandrosterone sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.14
reversible: false
type: Reaction
kinetic law: MODEL1310110059#
is: SBO:0000176

metaR NDPK1
reversible: true
reactant: MODEL1310110059#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110059#
name: nucleoside-diphosphate kinase (ATP:GDP)
fast: false
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_cadb5de3_7283_410a_9684_5836d271a210
name: PDE9A
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5152
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaR r0841
reactant: MODEL1310110059#
name: Free diffusion
kinetic law: MODEL1310110059#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.271
type: Reaction
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_27b8a9cb_09f5_4591_84ab_52a2a965e0f8
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q16647
is encoded by: hsa:5740
name: PTGIS
initial concentration: NaN

metaM no c
is: CHEBI:16480
constant: false
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
type: Species
has only substance units: false
is: C00533
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB03378

http://identifiers.org/biomodels.db/MODEL1310110059#_7a9b8a33_eb37_43c8_a4e5_f8feac200a08
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: AMPD2
is encoded by: hsa:271
has only substance units: false
constant: false
is: E9PNG0
boundary condition: true

metaR UGALNACtg
is: SBO:0000185
product: MODEL1310110059#
reversible: true
name: UDP-GalNAc Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110059#_7a6cdab6_1082_4f3b_8d64_cb9791427f74
is: SBO:0000252
is encoded by: hsa:35
boundary condition: true
constant: false
is: P16219
has only substance units: false
type: Species
initial concentration: NaN
name: ACADS
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_edc6fc40_724c_4b06_b89e_2732d75d3caa
initial amount: NaN
has only substance units: false
name: RRM1
is encoded by: hsa:6240
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: P23921
constant: false

metaM pro L m
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:17203
initial amount: NaN
is: HMDB00162
type: Species

metaR DNDPt15m
fast: false
name: dUDP transport via dGDP antiport
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#

metaM pheme c
initial concentration: 1.0
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
boundary condition: false
initial amount: NaN
is: CHEBI:17627
type: Species
has only substance units: false
is: C00032
is: SBO:0000247
is: HMDB03178
constant: false
name: Protoheme

metaM cholcoar x
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0
constant: false
is: CHEBI:58677
type: Species
is: HMDB02178
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial amount: NaN

metaR B3GNT39g
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000

metaM ttdcrn c
initial concentration: 1.0
is: SBO:0000247
name: tetradecanoyl carnitine
initial amount: NaN
is: HMDB05066
boundary condition: false
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
is: http://identifiers.org/pubchem.compound/3413344
constant: false
type: Species
has only substance units: false

metaR LGNCt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: fatty acid transport via diffusion
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_93c6259b_5d32_4ee5_ab5f_127c67cc0632
is encoded by: hsa:6532
name: SLC6A4
type: Species
is: P31645
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM retinol c
is: SBO:0000247
has only substance units: false
boundary condition: false
name: retinol
constant: false
is: CHEBI:50211
type: Species
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: HMDB00305
initial concentration: 1.0

metaM lnlccoa r
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
initial concentration: 1.0
has only substance units: false

metaR S6T1g
reactant: MODEL1310110059#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is: SBO:0000176
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM didp c
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:28823
initial amount: NaN
is: HMDB03536
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
type: Species
name: dIDP
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_65d101a8_a7cc_4d58_a0dd_df31d4d1ee12
has only substance units: false
constant: false
is encoded by: hsa:5860
type: Species
is: P09417
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: QDPR
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_031fab92_17b3_4712_9cf7_ebee282aca65
initial concentration: NaN
is encoded by: hsa:56474
initial amount: NaN
is: Q9NRF8
boundary condition: true
is: SBO:0000252
has only substance units: false
name: CTPS2
constant: false
type: Species

metaR ESTRONEtr
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000000
name: estrone intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110059#_f30311eb_297c_4f7d_9760_fafb5ff4d743
type: Species
initial amount: NaN
has only substance units: false
name: PPA2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:27068
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_78ace6ce_8c19_4ef1_aa38_32f50c788a48
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: Q6ZWT7
type: Species
boundary condition: true
name: MBOAT2
is encoded by: hsa:129642
is: SBO:0000252

metaR UROLACer
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110059#
reversible: true
name: uronolactonase, endoplasmic reticulum
is: SBO:0000176
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD

metaR RE1233C
reversible: true
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
reactant: MODEL1310110059#
modifier: MODEL1310110059#
name: RE1233
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is described by: ECO:0000000

metaR RE1447M
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
kinetic law: MODEL1310110059#
is: SBO:0000176
reversible: true
reactant: MODEL1310110059#
is described by: ECO:0000000
fast: false
product: MODEL1310110059#

metaR GGH 7DHFe
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM lnlncg c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
initial concentration: 1.0
constant: false
type: Species
name: gamma-linolenate
has only substance units: false
is: CHEBI:32391
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_c0f192a4_d86c_428c_9c7c_e56420760276
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI345944
initial amount: NaN
name: _AI345944_1_m

http://identifiers.org/biomodels.db/MODEL1310110059#_70cb3a92_5655_4b48_b0cb_efcb71e9c5ee
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PGAP1
is: Q75T13
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:80055
constant: false
type: Species

metaM glyb c
type: Species
initial concentration: 1.0
is: CHEBI:17750
is: HMDB00043
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: glycine betaine
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaR DCK2n
is: SBO:0000176
name: Deoxycytidine kinase, nuclear (UTP)
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
product: MODEL1310110059#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.1.74

metaM bilirub e
name: bilirubin(2-)
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57977
initial amount: NaN

metaR RETH
is: SBO:0000176
name: retinyl ester hydrolase
fast: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
product: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110059#_c471180b_c597_4af1_bd99_f6261d8a2b21
initial amount: NaN
name: HK2
boundary condition: true
has only substance units: false
is: P52789
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3099
type: Species
constant: false

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaM 5aop c
initial amount: NaN
boundary condition: false
is: HMDB01149
is: SBO:0000247
has only substance units: false
name: 5-Amino-4-oxopentanoate
initial concentration: 1.0
constant: false
is: C00430
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
type: Species
is: CHEBI:17549

metaM ksi deg20 l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
name: keratan sulfate I, degradation product 20
is: HMDB00143
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:12936

metaM glyc m
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00131
name: Glycerol
is: CHEBI:17754
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116

metaR TSULt4 3
reversible: true
fast: false
name: thiosulfate transport via sodium symport
modifier: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
is: SBO:0000185
product: MODEL1310110059#
is described by: ECO:0000269
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_93b0c5de_b9ea_48ed_9c23_c02e06a10dd7
name: _AL525798_1_c
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AL525798
type: Species
initial concentration: NaN

metaM dlnlcg e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02925
type: Species
is: CHEBI:53486
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
name: dihomo-gamma-linolenic acid (n-6)
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_865c4300_74f0_42ae_85d8_98aa53caf65a
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:513
constant: false
initial concentration: NaN
name: ATP5D

http://identifiers.org/biomodels.db/MODEL1310110059#_5b6e45a0_3f3a_4f2f_9ebc_0d281bd63999
is: Q96CD2
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: PPCDC
is encoded by: hsa:60490

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM c101crn c
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB13205
notes: FORMULA: C17H31NO4 CHARGE: 0
initial amount: NaN
name: decenoyl carnitine
boundary condition: false

metaR PCt
reversible: true
product: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110059#
name: phosphatidylcholine transporter
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
fast: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.6.3.44
reactant: MODEL1310110059#
type: Reaction

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR GLNSERNaEx
is described by: ECO:0000269
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false

metaR EX c8crn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaM m5masnB2 g
constant: false
is: SBO:0000247
notes: FORMULA: C52H87N2O40X CHARGE: 0
has only substance units: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: CHEBI:58401
boundary condition: false
type: Species
is: HMDB06814
initial amount: NaN
initial concentration: 1.0

metaM gm3 hs g
is: CHEBI:60065
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
type: Species
has only substance units: false

metaR UDPDOLPT L
reactant: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.117
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
modifier: MODEL1310110059#
is: SBO:0000176
fast: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
type: Reaction
product: MODEL1310110059#

metaM dolp U c
initial concentration: 1.0
is: CHEBI:57683
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
name: dolichyl phosphate(2-)
boundary condition: false
initial amount: NaN

metaM odecrn c
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: C00412
is: CHEBI:57394
name: octadecenoyl carnitine
type: Species
is: HMDB01114
is: SBO:0000247

metaR r0627
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
type: Reaction
product: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
reactant: MODEL1310110059#

metaR PHEACGLNt
is described by: ECO:0000000
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
fast: false
is: SBO:0000185
reactant: MODEL1310110059#
type: Reaction
name: PHEACGLN extracellular transport via diffusion

metaR FACOAL2252
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaR ATPH1e
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110059#
is described by: ECO:0000269
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
name: ATP diphosphohydrolase
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
type: Reaction
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_87b28489_abfe_4273_bc8a_53f334acada3
constant: false
name: CDS2
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8760
boundary condition: true
is: O95674
initial concentration: NaN
has only substance units: false

metaM glyc3p x
is: HMDB00126
is: SBO:0000247
is: CHEBI:57597
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
has only substance units: false

metaR r2364
product: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110059#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110059#

metaM glu L e
initial concentration: 1.0
initial amount: NaN
is: HMDB00148
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
name: L-glutamate(1-)
is: CHEBI:29985

http://identifiers.org/biomodels.db/MODEL1310110059#_3ad22121_ed20_440a_ba35_f7a953970613
name: SLC24A4
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:123041
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_e612f651_d6e0_4bae_931c_ad222923ddd8
is encoded by: hsa:4122
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: MAN2A2
is: Q9P1E4
type: Species

metaM cyan c
initial amount: NaN
is: HMDB02084
initial concentration: 1.0
has only substance units: false
name: hydrogen cyanide
constant: false
is: CHEBI:18407
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326

http://identifiers.org/biomodels.db/MODEL1310110059#_ebee14af_4bbb_464f_ada7_ce1f00d20850
initial concentration: NaN
is: P12074
boundary condition: true
constant: false
type: Species
name: COX6A1
is encoded by: hsa:1337
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r2363
type: Reaction
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_d2abfad8_2330_4cb8_9fea_fb05c47ba524
is: Q85KV6
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ND1
type: Species
is encoded by: hsa:4535

http://identifiers.org/biomodels.db/MODEL1310110059#_3d65d06e_60a3_4864_b603_b5aac41baf3f
has only substance units: false
is: A6NDW6
name: ALG8
constant: false
is encoded by: hsa:79053
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR FACOAL2251
modifier: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
fast: false
name: fatty-acid--CoA ligase
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM ksi pre35 g
constant: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
name: keratan sulfate I biosynthesis, precursor 35
has only substance units: false
is: CHEBI:28067
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM pmtcrn c
boundary condition: false
initial amount: NaN
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
name: L-palmitoylcarnitine
is: CHEBI:17490
has only substance units: false

metaR SGPL12r
is version of: http://identifiers.org/ec-code/4.1.2.27
name: Sphingosine-1-phosphate lyase
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000304
reversible: false

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_f8612717_6f03_442a_93ed_88419ae057d1
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:284111
boundary condition: true
is: Q86YT5
name: SLC13A5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_402e2345_fd9c_4450_87bc_72bd940d235c
initial concentration: NaN
constant: false
is encoded by: hsa:8402
is: SBO:0000252
type: Species
boundary condition: true
is: F5GY65
initial amount: NaN
has only substance units: false
name: SLC25A11

metaM subeac c
has only substance units: false
notes: FORMULA: C8H12O4 CHARGE: -2
initial amount: NaN
constant: false
name: suberic acid
is: HMDB00893
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_ef0dbe56_50c4_495f_a72e_5ab459f0fdef
initial amount: NaN
name: ACOT8
is: O14734
is encoded by: hsa:10005
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaR ALATHRNaEx
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
fast: false
modifier: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000269
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)

metaM atp m
is: C00002
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00538
constant: false
name: ATP(4-)
is: CHEBI:57299
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_e0386326_00b5_4ff9_a43c_17892bae0f17
has only substance units: false
is encoded by: hsa:113451
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q96A70
name: ADC
type: Species

metaM citr L m
is: CHEBI:16349
type: Species
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
is: SBO:0000247
has only substance units: false
name: L-citrulline
initial amount: NaN
constant: false
is: HMDB00904

metaM psyl e
initial amount: NaN
has only substance units: false
is: HMDB03402
name: psyllium
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
is: SBO:0000247
type: Species

metaR r2362
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM eicostetcrn c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: HMDB01356
name: Eicosatetranoyl carnitine
is: CHEBI:57312
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_d3e83afd_3229_46cf_9ee4_10ebd15aa60e
is encoded by: hsa:3242
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: B3KQ63
name: HPD
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_d6342426_974b_47e3_a485_0489416be1c6
is encoded by: hsa:6184
boundary condition: true
name: DAD1:DDOST:RPN1:RPN2
initial amount: NaN
is encoded by: hsa:1650
has part: P39656
is encoded by: hsa:1603
has only substance units: false
has part: P04844
has part: Q53G02
is: SBO:0000297
type: Species
initial concentration: NaN
is encoded by: hsa:6185
constant: false
has part: P04843

metaM 2dp6mep m
initial amount: NaN
name: 2-Decaprenyl-6-methoxyphenol
is: CHEBI:50774
initial concentration: 1.0
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR CMPSAS
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
name: CMP sialic acid synthase
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.43
is: SBO:0000176
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
is described by: ECO:0000304
product: MODEL1310110059#

metaM prostgh2 r
type: Species
boundary condition: false
is: HMDB01381
is: CHEBI:57405
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: prostaglandin H2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0

metaR ACONT
reversible: true
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
name: aconitase
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110059#
fast: false

metaM Ser Thr g
boundary condition: false
constant: false
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine or threonine residue (O-glycosylation site)
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:58336
initial concentration: 1.0
is: HMDB00645

metaR FRUt4
is: SBO:0000185
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
name: D-fructose transport via sodium cotransport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
is described by: ECO:0000269
fast: false

metaR SUCCt4 2
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
reversible: true
name: succinate transport via sodium symport
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110059#
is: SBO:0000185
type: Reaction

metaR DOLPMT1 Ler
is version of: http://identifiers.org/ec-code/2.4.1.258
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110059#
modifier: MODEL1310110059#

metaR r0345
fast: false
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110059#
reversible: true
product: MODEL1310110059#

metaM cyan e
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:18407
name: hydrogen cyanide
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_a9cf4bbc_f919_4ede_800a_0e2360cc5240
is: P15328
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2348
constant: false
has only substance units: false
is: SBO:0000252
name: FOLR1

metaR AMETt2m
kinetic law: MODEL1310110059#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
fast: false
product: MODEL1310110059#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
modifier: MODEL1310110059#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_97339893_5394_4179_af2f_8f24940aa0bf
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6675
name: UAP1
type: Species
has only substance units: false
initial amount: NaN
is: Q16222
boundary condition: true

metaM atp n
name: ATP(3-)
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
boundary condition: false
initial amount: NaN
is: CHEBI:57299
is: SBO:0000247
has only substance units: false
is: HMDB00538
constant: false
initial concentration: 1.0
type: Species

metaR r2361
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: true

metaM utp n
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:46398
is: HMDB00285
name: UTP(4-)
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
initial concentration: 1.0

metaR HACD9m
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
reversible: true
is: SBO:0000176
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_885c90c5_cc62_4971_9505_19b6a17d6a6b
initial amount: NaN
constant: false
has only substance units: false
name: SLC35B2
type: Species
boundary condition: true
initial concentration: NaN
is: Q8TB61
is: SBO:0000252
is encoded by: hsa:347734

http://identifiers.org/biomodels.db/MODEL1310110059#_91333408_606d_4532_b2e5_b0c97a5b45e7
is encoded by: hsa:411
has only substance units: false
type: Species
is: SBO:0000252
name: ARSB
constant: false
is: P15848
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_8a1c1f4b_a6bb_4dda_bb54_a0f5b1490ac6
initial concentration: NaN
has only substance units: false
is: P04075
is: SBO:0000252
is encoded by: hsa:226
constant: false
boundary condition: true
name: ALDOA
initial amount: NaN
type: Species

metaR Htg
type: Reaction
is: SBO:0000185
name: proton diffusion (Golgi)
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#

metaM octa c
is: C06423
has only substance units: false
is: CHEBI:25646
boundary condition: false
type: Species
is: HMDB00482
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: octanoate (n-C8:0)
constant: false
notes: FORMULA: C8H15O2 CHARGE: -1

metaR NDPK9
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:IDP)
is: SBO:0000176

metaR r2368
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110059#
fast: false

metaM dcsptn1coa c
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205483
is: C16173
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: HMDB06513

http://identifiers.org/biomodels.db/MODEL1310110059#_227e4ac2_11e5_4595_ab4b_0f19052dc72e
initial concentration: NaN
has only substance units: false
name: PDE5A
type: Species
initial amount: NaN
is encoded by: hsa:8654
is: SBO:0000252
boundary condition: true
constant: false

metaM HC01223 m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:57340
has only substance units: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: SBO:0000247
constant: false
type: Species

metaR NTP3e
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110059#
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110059#
name: nucleoside-triphosphatase (GTP)
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176

metaR C8CRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_8b85c888_9bc9_4ffd_b00f_260341ca4b71
is: SBO:0000252
initial concentration: NaN
name: ATIC
initial amount: NaN
is encoded by: hsa:471
has only substance units: false
constant: false
is: P31939
type: Species
boundary condition: true

metaM mlthf m
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
name: 5,10-Methylenetetrahydrofolate
boundary condition: false
has only substance units: false
is: C00143
is: CHEBI:15636
is: SBO:0000247
constant: false
is: HMDB01533
initial concentration: 1.0
initial amount: NaN
type: Species

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_622bc3b9_538c_4a40_a84d_920e673ffb61
name: ALDOA
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:226
has only substance units: false
is: SBO:0000252
type: Species
is: P04075

metaR FUMm
name: fumarase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110059#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
reversible: true
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_0859fa2d_5442_4e22_a8d9_0ff7d459ffc7
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:6647
type: Species
has only substance units: false
name: SOD1
initial amount: NaN
is: P00441
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_c8084052_41ac_49a3_87f6_60b4c29e81d3
has only substance units: false
type: Species
constant: false
boundary condition: true
name: PRODH2
is encoded by: hsa:58510
is: SBO:0000252
is: Q9UF12
initial amount: NaN
initial concentration: NaN

metaR NDPK8
reactant: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
fast: false
is described by: ECO:0000269
reversible: true
name: Nucleoside-diphosphate kinase (ATP:dADP)
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_c55f0ee9_b2b6_4222_8324_b9e51d597d50
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: P48448
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ALDH3B2
is encoded by: hsa:222

http://identifiers.org/biomodels.db/MODEL1310110059#_d75b7da5_5e99_4d47_874b_6a3d16ac1633
boundary condition: true
constant: false
is encoded by: hsa:8818
type: Species
is: SBO:0000252
has only substance units: false
name: DPM2
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_6ea56974_2486_43fb_8c02_3b0d876fcee3
type: Species
boundary condition: true
is: Q7LGC8
constant: false
is encoded by: hsa:9469
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: CHST3
is: SBO:0000252

metaR r2367
type: Reaction
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
fast: false

metaM pro L c
is: HMDB00162
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
name: L-proline
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17203
initial amount: NaN
type: Species

metaR NACHEX12ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110059#
product: MODEL1310110059#

metaM omhpal r
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: w-hydroxypalmiticacid
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C16H30O3 CHARGE: -1
is: HMDB06294
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_c603c9da_e7e7_4dcc_90ae_500066795a22
initial concentration: NaN
name: AASS
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10157
constant: false
type: Species
is: A4D0W4

metaM atp r
initial amount: NaN
is: C00002
is: HMDB00538
is: SBO:0000247
name: ATP(4-)
type: Species
is: CHEBI:57299
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_e32b3773_cd09_42e3_b788_b44e8de38a0b
is encoded by: hsa:5209
name: PFKFB3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q16875
constant: false
initial amount: NaN
type: Species

metaR NDPK7
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110059#
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP)
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110059#
is: SBO:0000176

metaM nad c
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
is: HMDB00902
is: CHEBI:57540
is: C00003

metaM octa e
name: octanoate (n-C8:0)
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00482
initial concentration: 1.0
constant: false
is: C06423

metaM c101crn e
notes: FORMULA: C17H31NO4 CHARGE: 0
is: HMDB13205
initial amount: NaN
type: Species
name: decenoyl carnitine
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR APOCFm
fast: false
is: SBO:0000176
name: Apocarboxylase formation, mitochondrial
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_4f993a39_9463_4a09_a9ac_e401ad03a1b3
is encoded by: hsa:2184
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: FAH
is: P16930
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_a29727f5_e66e_4ab9_b43c_378c208a4511
initial amount: NaN
type: Species
name: BHMT2
is: SBO:0000252
is encoded by: hsa:23743
boundary condition: true
is: Q9H2M3
constant: false
has only substance units: false
initial concentration: NaN

metaR r2366
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_713255e4_1a1b_4c41_81d9_9b3b85b0cb79
is encoded by: hsa:5167
initial amount: NaN
has only substance units: false
constant: false
name: ENPP1
boundary condition: true
is: P22413
type: Species
initial concentration: NaN
is: SBO:0000252

metaR IPDPtx
type: Reaction
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
kinetic law: MODEL1310110059#
name: Isopentenyl diphosphate transport (peroxisome)
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110059#
is: SBO:0000185
fast: false

metaM glu L c
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
name: L-glutamate(1-)
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:29985
initial concentration: 1.0
is: HMDB00148
is: SBO:0000247

metaM l2n2m2mn l
has only substance units: false
initial amount: NaN
is: HMDB00143
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
boundary condition: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: CHEBI:12936
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_bdd39695_dcd5_4158_869c_de98bb0bb405
is encoded by: hsa:10449
constant: false
is: P42765
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ACAA2

http://identifiers.org/biomodels.db/MODEL1310110059#_ff2319fb_5675_416e_a3d4_da61d9565334
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: _D29675_1_c
boundary condition: true
is encoded by: hsa:D29675
is: SBO:0000252

metaM mi1p D c
is: HMDB02985
name: 1D-myo-inositol 1-phosphate(2-)
is: SBO:0000247
is: CHEBI:58433
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial amount: NaN

metaM arg L m
initial concentration: 1.0
type: Species
is: CHEBI:32682
has only substance units: false
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
constant: false
is: HMDB00517
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_0d7cd242_b8e0_4f8f_adc0_22b0612849d5
is encoded by: hsa:117247
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC16A10
has only substance units: false
is: Q8TF71

metaR r0620
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.7
reversible: true
name: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_05653075_38d3_411b_97ab_f107b5eb53ca
is encoded by: hsa:4709
is: SBO:0000252
initial amount: NaN
name: NDUFB3
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: Q6IB80
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_fd14da7e_7789_4d45_b34b_dcde9cee2660
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P40926
is encoded by: hsa:4191
has only substance units: false
name: MDH2
initial amount: NaN
type: Species
constant: false

metaR NDPK6
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dUDP)

http://identifiers.org/biomodels.db/MODEL1310110059#_c59f01a7_4da7_4dec_9334_099a30df77d8
name: DECR1
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: Q16698
type: Species
is: SBO:0000252
is encoded by: hsa:1666
boundary condition: true

metaR MANtly
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110059#
name: mannose efflux from lysosome
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false

metaR BILIRED
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.24
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
product: MODEL1310110059#
is: SBO:0000176
name: Nad(p)h biliverdin reductase
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reversible: false

metaR FAOXC122m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR r2365
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110059#
type: Reaction
reversible: true
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000185
fast: false

metaM bildglcur r
is: CHEBI:58471
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
is: HMDB03325
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: bis(beta-glucosyluronate)bilirubin
is: SBO:0000247

metaR ENGASEly
reversible: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
name: endo-beta-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
type: Reaction

metaR 4HBZFm
product: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reversible: false
is described by: ECO:0000000
name: 4-hydroxybenzoate formation
kinetic law: MODEL1310110059#
fast: false
type: Reaction
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_359e32de_bc24_4a7e_9bdc_eefde73febf9
name: OXSM
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:54995
has only substance units: false
is: Q9NWU1
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaM pd3 c
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06500
name: Previtamin D3

http://identifiers.org/biomodels.db/MODEL1310110059#_0687a412_0fc7_4357_90cf_eee7bb332fe5
is: P36269
has only substance units: false
name: GGT5
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:2687
initial concentration: NaN

metaM pro L e
boundary condition: false
is: SBO:0000247
constant: false
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
has only substance units: false
is: CHEBI:17203
initial amount: NaN
type: Species
is: HMDB00162

http://identifiers.org/biomodels.db/MODEL1310110059#_f9dda2c6_6b34_4598_bd0b_c92528b10c00
is encoded by: hsa:54963
constant: false
initial concentration: NaN
initial amount: NaN
is: Q53HM1
name: UCKL1
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaR r1088
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#
is: SBO:0000185
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

metaM atp c
initial concentration: 1.0
is: HMDB00538
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
name: ATP(4-)
type: Species
is: CHEBI:30616
is: SBO:0000247
is: C00002

http://identifiers.org/biomodels.db/MODEL1310110059#_76326bb2_627d_4253_8868_87433f9053ab
initial amount: NaN
is: Q9BWD1
initial concentration: NaN
name: ACAT2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:39
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_eee69d00_582d_4e1b_b0f3_2f7258a2d1f1
is: Q9H903
initial concentration: NaN
has only substance units: false
type: Species
name: MTHFD2L
initial amount: NaN
is encoded by: hsa:441024
is: SBO:0000252
boundary condition: true
constant: false

metaR URAt
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: true
name: uracil transport via facilated diffusion
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
product: MODEL1310110059#
reactant: MODEL1310110059#

metaR LNELDCCRNt
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
fast: false
type: Reaction
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
is: SBO:0000185

metaR VLCSr
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
type: Reaction
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase

metaR r0340
reversible: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110059#

metaR FAOXC121C101m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaM utp e
initial concentration: 1.0
is: HMDB00285
name: UTP(4-)
has only substance units: false
type: Species
is: CHEBI:46398
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_a33f4e3e_f10a_4a9a_840a_7486fa961c9f
is: O00483
is encoded by: hsa:4697
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: NDUFA4

metaM ksii core2 deg9 l
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: keratan sulfate II (core 2-linked), degradation product 9
is: CHEBI:12936
is: HMDB00143
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_fb45a549_fbb5_4dd7_81b0_513f65a9ad16
boundary condition: true
initial amount: NaN
name: ALG12
is: SBO:0000252
constant: false
is: Q9BV10
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:79087

metaR r0990
kinetic law: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
type: Reaction

metaR r0779
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
reversible: false
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false

metaR MANtg
kinetic law: MODEL1310110059#
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: mannose efflux from Golgi apparatus
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_93c1f7b3_1330_4a6c_ade6_6bea100e602b
is encoded by: hsa:5331
constant: false
is: G5E960
is: SBO:0000252
boundary condition: true
type: Species
name: PLCB3
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM Rtotalcoa c
is: SBO:0000247
name: R total Coenzyme A
initial concentration: 1.0
is: HMDB01448
type: Species
has only substance units: false
is: CHEBI:16189
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4

metaM mi1p D n
initial amount: NaN
is: CHEBI:58433
has only substance units: false
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
is: HMDB02985
constant: false

metaR LEUKTRA4t
is described by: ECO:0000269
fast: false
reactant: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
type: Reaction
name: leukotriene A4 transport
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_c87e869b_a0ea_49d8_baf5_f7e4e3c9f494
name: PDE9A
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5152
constant: false
boundary condition: true

metaM ttdcrn m
boundary condition: false
name: tetradecanoyl carnitine
constant: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3413344
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
initial amount: NaN
is: HMDB05066

metaM hx2coa m
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
boundary condition: false
is: C05998
is: SBO:0000247
initial amount: NaN
is: HMDB06870
is: http://identifiers.org/pubchem.compound/11966188
name: trans-Hex-2-enoyl-CoA
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

metaR Htr
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: H transporter, endoplasmic reticulum
product: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185

metaR EX tetdece1crn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaM atp e
is: CHEBI:57299
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00538
has only substance units: false
initial amount: NaN
constant: false
is: C00002
name: ATP(4-)
boundary condition: false

metaR C4STMO2r
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.14.13.72
name: C-4 methyl sterol oxidase
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reversible: false
reactant: MODEL1310110059#

metaR S6T11g
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false

metaR FAOXC205C184x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaR FAOXTC122m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaM citr L e
is: SBO:0000247
name: citr_L[e]
is: HMDB00904
type: Species
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
is: CHEBI:16349
boundary condition: false
constant: false
initial amount: NaN

metaR TTDCRNt
reversible: false
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110059#
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#

metaM bilirub r
is: HMDB00054
initial amount: NaN
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
name: bilirubin(2-)
has only substance units: false
is: CHEBI:57977
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR GLCAASE8ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110059#
fast: false
name: beta-glucuronidase, lysosomal
reversible: false
kinetic law: MODEL1310110059#

metaR VLCSp
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110059#
type: Reaction

metaR ARACHCPT1
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
name: carnitine transferase
is: SBO:0000176
reversible: false
product: MODEL1310110059#
type: Reaction

metaM g6p r
is: HMDB01401
initial concentration: 1.0
is: C00092
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:61548
name: D-Glucose 6-phosphate
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: SBO:0000247

metaR SEBCOAPET
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM ksi pre13 g
is: C00130
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 13
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
initial amount: NaN
is: CHEBI:58053
is: HMDB00175

metaR H2MTer U
kinetic law: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
reversible: false
name: H2 mannosyltransferase, endoplasmic reticulum
type: Reaction
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_9305c8b2_54ea_4de6_8f3d_4b46855e669b
has part: P15531
is encoded by: hsa:4830
name: NME1:NME2
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:4831
has part: P22392
is: SBO:0000297
constant: false
initial concentration: NaN
initial amount: NaN

metaR r2079
kinetic law: MODEL1310110059#
product: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_20e3dbe6_9c83_44e6_adb4_09a5ee1248c3
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:210
is: Q6ZMU0
initial concentration: NaN
name: ALAD
constant: false
is: SBO:0000252

metaR ARACHCPT2
reversible: false
product: MODEL1310110059#
is described by: ECO:0000000
name: carnitine transferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
type: Reaction
modifier: MODEL1310110059#

metaM pcrn c
is: SBO:0000247
type: Species
constant: false
is: HMDB00824
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738
boundary condition: false
name: propionyl-carnitine
initial amount: NaN

metaM bildglcur e
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
boundary condition: false
is: HMDB03325
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
type: Species
initial concentration: 1.0
constant: false
has only substance units: false

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR TETPENT6t
is described by: ECO:0000000
name: fatty acid transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM citr L c
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
is: HMDB00904
boundary condition: false
type: Species
name: L-citrulline
is: CHEBI:16349
is: SBO:0000247

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM 3hbcoa m
is: HMDB01166
initial amount: NaN
is: CHEBI:57316
boundary condition: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
type: Species
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_5b8e4cff_dee0_4fd4_9232_faa9b8b12a7f
boundary condition: true
is encoded by: hsa:1716
constant: false
is: E5KSL6
has only substance units: false
initial amount: NaN
name: DGUOK
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110059#
name: Organic anion transporter 5 Utilized transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
reversible: true

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR NDPK5n
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
reversible: true

metaM spmd e
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: C00315
is: HMDB01257
initial amount: NaN
is: CHEBI:57834
is: SBO:0000247
name: Spermidine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_942cdfa5_9ed3_46a0_b34e_ee4ae1b1c75f
is encoded by: hsa:2717
initial concentration: NaN
type: Species
constant: false
name: GLA
is: Q53Y83
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r0994
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110059#
reversible: true
name: Facilitated diffusion

metaM lnlccoa c
has only substance units: false
initial concentration: 1.0
constant: false
name: linoleic coenzyme A
initial amount: NaN
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+

http://identifiers.org/biomodels.db/MODEL1310110059#_2f7b7b04_ec5b_40ec_b04d_547410bfedc6
is: Q9HC21
type: Species
is: SBO:0000252
name: SLC25A19
constant: false
is encoded by: hsa:60386
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_91e6612d_dcfd_48a0_ab77_6cac6733c113
boundary condition: true
has only substance units: false
constant: false
type: Species
is: P54709
is encoded by: hsa:483
name: ATP1B3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_75b11f94_64a5_4c70_9d78_f4ba9e91bd6d
type: Species
name: PDE9A
is encoded by: hsa:5152
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM fad x
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
is: HMDB01248

metaM hs deg16 l
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
name: heparan sulfate, degradation product 16
is: HMDB02704
is: CHEBI:21338
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_ea75f924_67ac_4375_9568_90608e5b9a57
boundary condition: true
initial concentration: NaN
name: CKB
is: SBO:0000252
type: Species
is: P12277
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:1152

metaM glyc3p m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00126
is: C00093
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
is: CHEBI:57597
name: Glycerol 3-phosphate

metaM HC02202 e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
type: Species
name: prostaglandin A1(1-)
is: CHEBI:57398
initial concentration: 1.0

metaR CRNrtx
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
is described by: ECO:0000134
fast: false
name: reversible transport of L-Carnitine in peroxisome
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.

metaM g1m8mpdol L r
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
type: Species
is: C05870
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247

metaM acgam6p c
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57513
has only substance units: false
is: SBO:0000247
is: HMDB01062
name: N-acetyl-D-glucosamine 6-phosphate(2-)

metaR FATP4t
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
name: fatty acid electroneutral transport
fast: false
is described by: ECO:0000269
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
kinetic law: MODEL1310110059#
reversible: true

metaR PRO Dtde
name: D-proline transport, extracellular
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaR METt4
fast: false
modifier: MODEL1310110059#
name: L-methionine transport in via sodium symport
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
type: Reaction
is: SBO:0000185
product: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR r0629
fast: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.6.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction
reactant: MODEL1310110059#
reversible: true

metaM em2emgacpail hs r
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:16240
constant: false
boundary condition: false
is: HMDB03125

http://identifiers.org/biomodels.db/MODEL1310110059#_cf7da506_e20e_473c_82a3_1e25da9c9051
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SOD2
type: Species
is encoded by: hsa:6648
is: P04179

metaR IDOAASE3ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.76
modifier: MODEL1310110059#
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_0a8e29ca_000b_43a6_8081_53d89fc11471
has only substance units: false
name: PIP5K1B
initial amount: NaN
is: O14986
boundary condition: true
is encoded by: hsa:8395
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_6be0b12b_ea68_4a1c_8405_91025318e039
is: Q16678
initial concentration: NaN
is encoded by: hsa:1545
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: CYP1B1

metaM prostgh2 e
is: HMDB01381
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57405
name: prostaglandin H2(1-)
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

http://identifiers.org/biomodels.db/MODEL1310110059#_84f8d939_eb49_44b4_81b9_4a86956b4eda
name: GCDH
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2639
constant: false
is: Q92947
type: Species
initial amount: NaN
is: SBO:0000252

metaM utp c
type: Species
is: C00075
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
is: CHEBI:46398
has only substance units: false
initial amount: NaN
is: HMDB00285
initial concentration: 1.0
name: UTP
boundary condition: false

metaR MTHFD2
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000134
name: methylenetetrahydrofolate dehydrogenase (NAD)
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_6b9774f4_9766_4943_bcf0_edbcce9e0336
is: Q9BZX2
is encoded by: hsa:7371
type: Species
name: UCK2
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_ecf07670_8aa2_4678_992e_30930779a3fe
is: SBO:0000252
type: Species
initial concentration: NaN
name: PLCE1
initial amount: NaN
is encoded by: hsa:51196
is: Q9P212
constant: false
boundary condition: true
has only substance units: false

metaM dlnlcg c
name: dihomo-gamma-linolenic acid (n-6)
constant: false
is: HMDB02925
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: CHEBI:53486
initial amount: NaN
has only substance units: false

metaR CHLtm
name: choline transport via diffusion (cytosol to mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reactant: MODEL1310110059#
type: Reaction
fast: false
reversible: true
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_af8a389e_b402_4b57_99ee_7b7e02388914
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AI972237
initial concentration: NaN
type: Species
constant: false
name: _AI972237_1_c

http://identifiers.org/biomodels.db/MODEL1310110059#_0d1aa605_c994_4ac3_8d2d_3ae1cfced914
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:10905
is: O60476
has only substance units: false
initial concentration: NaN
name: MAN1A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_9fede369_2431_4fa5_8e36_a307afb20960
has only substance units: false
is: Q14376
type: Species
is encoded by: hsa:2582
boundary condition: true
initial amount: NaN
name: GALE
constant: false
is: SBO:0000252
initial concentration: NaN

metaM HC02202 c
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false
type: Species
name: prostaglandin A1(1-)
initial concentration: 1.0
is: CHEBI:57398

metaR C40CPT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaR ACACT1rm
product: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: true
reactant: MODEL1310110059#
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_ccfc7a7f_02d8_49f8_b149_f0e991d90f70
name: GCSH
is encoded by: hsa:2653
has only substance units: false
is: P23434
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaM f6p c
is: C00085
is: HMDB00124
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: CHEBI:57579
is: http://identifiers.org/pubchem.compound/3385
name: D-Fructose 6-phosphate
initial amount: NaN

metaR RTOTALFATPc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_2c55f951_01fe_4783_9ab4_5dd5a84ea5c6
is: O95479
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: H6PD
initial concentration: NaN
is encoded by: hsa:9563
is: SBO:0000252

metaR DGULND
reversible: true
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
name: dehydro-L-gulonate decarboxylase
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110059#

metaR MTHFC
kinetic law: MODEL1310110059#
name: methenyltetrahydrofolate cyclohydrolase
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
product: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000134
fast: false

metaM val L e
type: Species
constant: false
is: HMDB00883
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: L-valine
is: CHEBI:16414
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174

metaR GLYC3Ptmc
name: glycerol-3-phopshate transport, cytoplasm
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
is: SBO:0000185
reversible: true
is described by: ECO:0000134
fast: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR HOXG
kinetic law: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
is described by: ECO:0000134
reversible: false
name: Heme oxygenase 1
reactant: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.3
modifier: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme

http://identifiers.org/biomodels.db/MODEL1310110059#_aca93123_717b_4d53_86fc_87094ec5e6b8
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: _AF116616_1_m
initial amount: NaN
is encoded by: hsa:AF116616
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_3b3bee3e_23ac_406f_a33d_0ba42775040c
has only substance units: false
is encoded by: hsa:226
initial amount: NaN
boundary condition: true
name: ALDOA
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_b776e8a9_fa6d_4569_8722_c6bf76a8605d
name: HMGCR
type: Species
boundary condition: true
is: P04035
constant: false
is encoded by: hsa:3156
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR MTHFD
modifier: MODEL1310110059#
name: methylenetetrahydrofolate dehydrogenase (NADP)
reactant: MODEL1310110059#
is described by: ECO:0000134
product: MODEL1310110059#
type: Reaction
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y

metaM sphs1p c
name: sphingosine 1-phosphate(1-)
boundary condition: false
is: HMDB00277
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species
constant: false

metaR DOLASNT Ler
product: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.119
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110059#

metaM tyr L m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17895
name: L-tyrosine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
has only substance units: false
type: Species
constant: false
is: HMDB00158

http://identifiers.org/biomodels.db/MODEL1310110059#_a5c603db_ec69_4676_a366_6e5eedd79f6d
boundary condition: true
initial amount: NaN
has only substance units: false
name: NDUFA7
is: Q6FG42
type: Species
is encoded by: hsa:4701
initial concentration: NaN
is: SBO:0000252
constant: false

metaM tetpent6coa c
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-6
is: C16172
initial amount: NaN

metaR BAAT1x
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
reversible: false
is: SBO:0000176
reactant: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
name: bile acid Coenzyme A: amino acid N-acyltransferase
kinetic law: MODEL1310110059#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110059#
type: Reaction

metaM datp m
initial concentration: 1.0
is: SBO:0000247
is: C00131
has only substance units: false
is: HMDB01532
constant: false
is: CHEBI:61404
initial amount: NaN
name: dATP
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131

metaR C12DCACT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

metaR G14T11g
is: SBO:0000176
type: Reaction
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110059#
reversible: false
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR r1905
product: MODEL1310110059#
fast: false
reversible: false
reactant: MODEL1310110059#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE2814R
reversible: true
product: MODEL1310110059#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110059#
is: SBO:0000176
name: RE2814

metaR RE1691M
is: SBO:0000176
product: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.8.1.1
is described by: ECO:0000000
name: RE1691
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
reversible: true
modifier: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#

metaM lcts e
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17716
is: C00243
name: Lactose
is: HMDB00186
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_274612bc_98e8_42a3_9f64_482c3ee36f05
is: Q16851
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7360
initial amount: NaN
has only substance units: false
name: UGP2
constant: false

metaM val L c
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00883
initial amount: NaN
name: L-valine
boundary condition: false
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174

metaM pcreat m
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01511
has only substance units: false
name: N-phosphocreatinate(2-)
is: CHEBI:58092
is: SBO:0000247
constant: false
notes: FORMULA: C4H9N3O5P CHARGE: -1 INCHI: InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12)/p-2 EHMN_ABBREVIATION: C02305
initial concentration: 1.0

metaR PSYTCHe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_eed87e6c_3650_4d19_8bd2_9e37c4d71a76
name: ADA
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: P00813
is encoded by: hsa:100

metaR UMPK6n
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110059#
name: UMP kinase (dCTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110059#_0c694de7_bda3_49ae_9266_18c62faca858
type: Species
has only substance units: false
name: PIGW
is: SBO:0000252
constant: false
initial amount: NaN
is: Q7Z7B1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:284098

metaM docoscoa x
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C43H74N7O17P3S CHARGE: -4
initial amount: NaN
name: docosanoylcoa
initial concentration: 1.0
boundary condition: false
is: HMDB12930
constant: false

metaR r1904
name: Y+LAT2 Utilized transport
modifier: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaR HIStN1
name: Histidine transport (Na, H coupled)
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110059#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_0a90ca04_d5c1_454a_a6de_bf272baee2e3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: GUCY2D
constant: false
has only substance units: false
initial amount: NaN
is: Q02846
is encoded by: hsa:3000
type: Species

metaM mi14p c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
has only substance units: false
is: CHEBI:58282
is: HMDB00968
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_d16e1f9f_a6bd_470a_bd0a_f7c5f5bdba13
name: SLC15A2
initial amount: NaN
is: Q16348
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:6565

metaR FAOXC1811603m
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
product: MODEL1310110059#
name: Beta oxidation fatty acid

metaM mal L m
initial amount: NaN
initial concentration: 1.0
is: HMDB00156
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589

metaR FALDtm
is: SBO:0000185
is described by: ECO:0000000
name: formaldehyde transport via diffusion (mitochondrial)
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM

metaM 2mbcoa m
boundary condition: false
has only substance units: false
is: CHEBI:57336
name: 2-methylbutanoyl-CoA(4-)
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: HMDB01041
is: SBO:0000247
initial amount: NaN

metaR CSPG Btly
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110059#
name: chondroitin sulfate B transport, extracellular to lysosome
reactant: MODEL1310110059#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110059#_fd7a8c58_7065_4e15_9c19_5ec5f825807f
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:7357
is: Q16739
name: UGCG
type: Species

metaM lcts g
name: lactose
constant: false
has only substance units: false
is: CHEBI:17716
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: HMDB00186
initial concentration: 1.0
type: Species

metaR RE2998M
product: MODEL1310110059#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
name: RE2998
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaR HDDACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM dhdascb e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58070
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: HMDB01264
constant: false
type: Species
name: dehydroascorbide(1-)
boundary condition: false
has only substance units: false

metaM g3m8mpdol L r
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: C00459
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
is: HMDB01342
is: CHEBI:37568
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

http://identifiers.org/biomodels.db/MODEL1310110059#_8466ff84_cfa8_49bc_85a4_a1d77178d4a0
is: SBO:0000252
initial concentration: NaN
constant: false
name: NDUFB9
is encoded by: hsa:4715
initial amount: NaN
type: Species
is: Q9Y6M9
boundary condition: true
has only substance units: false

metaR ARSA
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: false
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.6.8
name: Arylsulfatase A
fast: false

metaR r0365
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
modifier: MODEL1310110059#
reversible: false
type: Reaction
product: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

metaR GLYCLTDy
product: MODEL1310110059#
is: SBO:0000176
name: Glycolate dehydrogenase (NADP)
is described by: ECO:0000269
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:2689175 NOTES:JLR
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.79

metaR C162OHe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaR RE1534M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
name: RE1534
reactant: MODEL1310110059#
reversible: true
product: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#

metaR FAOXC225m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR FAOXTC102C101m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_86755381_c4e9_47b9_9723_b60ce7a101b2
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:3141
name: HLCS
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P50747

metaR GLYCTDle
is: SBO:0000185
fast: false
is described by: ECO:0000134
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
reversible: true
name: difussion of glycerol accross the brush border membrane

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR METtec
fast: false
modifier: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185
name: L-methionine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110059#
reversible: true
is described by: ECO:0000269
type: Reaction

metaM core3 g
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:16250
name: Core 3
initial amount: NaN
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false

metaR HDECEACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM pmtcoa c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:3454
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: C00154
is: HMDB01338
boundary condition: false
is: SBO:0000247

metaR CGLYt3 2
reversible: false
name: Cys-Gly transport in via proton symport
is described by: ECO:0000304
modifier: MODEL1310110059#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
reactant: MODEL1310110059#
product: MODEL1310110059#

metaM tmndnccoa c
initial amount: NaN
boundary condition: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06514
name: timnodonyl coenzyme A
constant: false
is: SBO:0000247

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR C4STMO2Pr
reversible: false
reactant: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
name: C-4 methyl sterol oxidase
is: SBO:0000176
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
modifier: MODEL1310110059#

metaM dhdascb c
initial concentration: 1.0
is: HMDB01264
name: dehydroascorbide(1-)
constant: false
boundary condition: false
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
has only substance units: false
initial amount: NaN
is: CHEBI:58070
is: SBO:0000247

metaR ADRNt
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110059#

metaM HC01401 m
is: CHEBI:27668
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

metaR C162OHc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_fab5695c_708a_4578_b17f_5a9d57834769
type: Species
initial concentration: NaN
is encoded by: hsa:1603
initial amount: NaN
is: Q53G02
is: SBO:0000252
constant: false
boundary condition: true
name: DAD1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_b2a190f6_80f4_47fe_b031_79d67be88acf
type: Species
is encoded by: hsa:23396
initial amount: NaN
is: O60331
is: SBO:0000252
name: PIP5K1C
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaM tymsf e
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
constant: false
name: Tyramine O-sulfate
has only substance units: false
initial concentration: 1.0
is: HMDB06409
type: Species

metaR DAGKn hs
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110059#
reversible: true
product: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_8a770db3_df98_453d_86a2_24f4eb01765c
name: ADH1B
is encoded by: hsa:125
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: P00325
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_3165cfb1_e6a7_4e79_b5f8_155dddbc0f67
initial concentration: NaN
type: Species
is encoded by: hsa:10861
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC26A1

metaR SQLEr
name: Squalene epoxidase, endoplasmic reticular (NADP)
type: Reaction
fast: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.14.13.132
reactant: MODEL1310110059#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
reversible: false
is: SBO:0000176
product: MODEL1310110059#
modifier: MODEL1310110059#

metaM sphs1p e
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
is: HMDB00277
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:60119

http://identifiers.org/biomodels.db/MODEL1310110059#_0e3c74f7_06df_40d0_9577_fd45dd211430
constant: false
type: Species
is: Q9H6Y6
is encoded by: hsa:4645
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: MYO5B

metaR UMPK
name: UMP kinase
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR DNDPt23m
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
kinetic law: MODEL1310110059#
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110059#
modifier: MODEL1310110059#
name: dTDP transport via dGTP antiport
is described by: ECO:0000269

metaR SIAT9g
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.9
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
reversible: false
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
type: Reaction

metaM HC00695 m
has only substance units: false
constant: false
name: S-Succinyldihydrolipoamide
is: SBO:0000247
is: CHEBI:17432
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_fb984fad_7adb_4d93_8300_043da2a66e23
type: Species
initial amount: NaN
has only substance units: false
name: LDHB
is: SBO:0000252
is encoded by: hsa:3945
initial concentration: NaN
boundary condition: true
constant: false
is: P07195

http://identifiers.org/biomodels.db/MODEL1310110059#_63ba899c_bd96_490b_b8ca_e30c5cac8331
name: SLC35D2
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:11046
is: Q76EJ3

metaR C10DCc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaM malt e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00163
is: C00208
name: Maltose
boundary condition: false
type: Species
constant: false
is: CHEBI:17306
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208

http://identifiers.org/biomodels.db/MODEL1310110059#_deb50cc9_7c22_4c04_a559_25eebdaa1307
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: QPRT
is: Q15274
is encoded by: hsa:23475
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_d14385dd_a473_463c_8e80_b963eed3266e
is: Q92911
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6528
type: Species
name: SLC5A5
initial amount: NaN
constant: false
boundary condition: true

metaM 4abut m
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
has only substance units: false
is: HMDB00112
is: SBO:0000247
boundary condition: false
is: CHEBI:16865
is: C00334
name: 4-Aminobutanoate
constant: false

metaM HC01401 x
name: (S)-3-Hydroxydodecanoyl-CoA
is: CHEBI:27668
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial concentration: 1.0
boundary condition: false

metaR ASNCYSNaEx
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
fast: false
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#

metaR TTDCAFATPc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR FATP1t
name: fatty acid electroneutral transport
kinetic law: MODEL1310110059#
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ

metaR RE3272N
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110059#
is: SBO:0000176
name: RE3272
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
reversible: true

metaM CE5117 m
has only substance units: false
boundary condition: false
type: Species
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57923
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117

http://identifiers.org/biomodels.db/MODEL1310110059#_aee447d8_79a2_4e01_a7af_bb2cd903350c
has only substance units: false
initial amount: NaN
is encoded by: hsa:80339
is: SBO:0000252
is: Q9NST1
boundary condition: true
name: PNPLA3
constant: false
type: Species
initial concentration: NaN

metaM 3ivcrn e
is: HMDB13336
name: 3-hydroxy-isovaleryl carnitine
notes: FORMULA: C12H23NO5 CHARGE: 0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

metaM tststerones e
is: SBO:0000247
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
type: Species
name: testosterone sulfate
initial amount: NaN
is: HMDB02833
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_fa4702b8_c31d_4b5e_96bd_6fb52f186566
type: Species
constant: false
is encoded by: hsa:4522
has only substance units: false
name: MTHFD1
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P11586
initial concentration: NaN

metaM tetdec2crn c
initial concentration: 1.0
name: tetradecadienoyl carnitine
boundary condition: false
type: Species
notes: FORMULA: C21H37NO4 CHARGE: 0
has only substance units: false
is: SBO:0000247
is: HMDB02014
constant: false
initial amount: NaN

metaR r2140
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM dag hs r
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: diglyceride
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_e779e294_c6df_45af_95b9_167d54467348
is: Q53Y25
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2645
name: GCK
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_82ff9966_a593_43a3_a809_24a244490668
name: MTMR3
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8897
is: SBO:0000252
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1c54408d_a43f_4201_b4fd_f04a4f921575
boundary condition: true
type: Species
is encoded by: hsa:3028
name: HSD17B10
is: Q99714
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_923788cb_e9cd_44d7_be81_ddb49c15a055
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:54
boundary condition: true
is: P13686
name: ACP5
has only substance units: false
initial concentration: NaN

metaM caro c
type: Species
initial concentration: 1.0
is: CHEBI:17579
name: beta-carotene
boundary condition: false
is: HMDB00561
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094

http://identifiers.org/biomodels.db/MODEL1310110059#_f10464a5_e4f3_4b90_b0b7_89938ac39e26
has only substance units: false
boundary condition: true
is: P15531
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:4830
initial amount: NaN
is: SBO:0000252
name: NME1

http://identifiers.org/biomodels.db/MODEL1310110059#_55d66e77_adc3_4ae2_b1fc_bb5dfe0841f0
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:AA614647
boundary condition: true
initial concentration: NaN
name: _AA614647_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_2b608910_9105_4e00_b3ff_faf4529fd94c
constant: false
initial amount: NaN
has only substance units: false
is: P14060
is: SBO:0000252
is encoded by: hsa:3283
name: HSD3B1
boundary condition: true
initial concentration: NaN
type: Species

metaM ksi pre18 g
is: HMDB00175
is: C00130
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
name: keratan sulfate I biosynthesis, precursor 18
initial amount: NaN
is: CHEBI:58053
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_51f5cd7f_7bf8_44d1_a500_68546a79ba8a
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:7296
name: TXNRD1
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR 3HBCOARc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (R)-3-hydroxybutanoyl-CoA into cytosol
type: Reaction

metaM fe2 e
is: CHEBI:29033
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: HMDB00692
is: C00023
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial concentration: 1.0
has only substance units: false
name: Fe2+
boundary condition: false

metaM 3ivcrn c
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB06870
is: http://identifiers.org/pubchem.compound/11966188
constant: false
name: 3-hydroxy-isovaleryl carnitine
notes: FORMULA: C12H23NO5 CHARGE: 0
is: C05998
has only substance units: false

metaR r2141
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110059#

metaR IDOAASE4ly
fast: false
kinetic law: MODEL1310110059#
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110059#
is described by: ECO:0000000
name: alpha-L-iduronidase, lysosomal
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.76
modifier: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_40a2a06b_cc82_4aea_9e4f_824eb336accc
is: B2R892
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1158
initial amount: NaN
has only substance units: false
name: CKM
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_179b1b8e_bea4_42b0_a6b9_96adf72691c3
type: Species
initial concentration: NaN
is encoded by: hsa:1607
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: DGKB

metaR CITtbm
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
is: SBO:0000185
reversible: true
modifier: MODEL1310110059#
name: citrate transport, mitochondrial
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#

metaM dhbpt c
initial concentration: 1.0
is: CHEBI:20680
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00038
name: 6,7-dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: SBO:0000247
boundary condition: false

metaM em2emgacpail prot hs r
is: SBO:0000247
type: Species
initial concentration: 1.0
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
is: HMDB00618
is: CHEBI:58121
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110059#_f3994fd8_5b9e_455e_b0a1_f76a3be9e495
is encoded by: hsa:5832
boundary condition: true
initial amount: NaN
name: ALDH18A1
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: P54886
constant: false

metaR 7DHCHSTEROLtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
type: Reaction
name: cholesterol precursor intracellular transport
product: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR NCKt
kinetic law: MODEL1310110059#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-K+ exchange
fast: false
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000185

metaR PCHOL HSter
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
product: MODEL1310110059#
name: phosphatidylcholine scramblase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:

metaR DM atp c
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
kinetic law: MODEL1310110059#
name: DM_atp(c)
is: SBO:0000176
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false

metaM ksii core2 deg6 l
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:12936
type: Species
notes: FORMULA: C44H72N4O33SX CHARGE: -1
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 6
initial concentration: 1.0
constant: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110059#_c0b960c0_1949_47ca_b7bd_b0e951772cf6
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q6PCB7
name: SLC27A1
is encoded by: hsa:376497
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r1464
reversible: true
is: SBO:0000185
name: Active transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
type: Reaction
reactant: MODEL1310110059#

metaM dgchol x
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
is: HMDB00637
is: CHEBI:36252
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r2142
type: Reaction
kinetic law: MODEL1310110059#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
reversible: true
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_8fa423c0_418f_40f3_acc5_594b387c5946
initial concentration: NaN
is: P51857
name: AKR1D1
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:6718
is: SBO:0000252
constant: false
boundary condition: true

metaM man r
has only substance units: false
constant: false
is: HMDB00169
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
is: CHEBI:16024
initial amount: NaN
name: D-mannose
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_31b4e1d9_6574_45a7_af0e_73fb45cc4059
constant: false
is encoded by: hsa:D29675
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: _D29675_1_e
initial amount: NaN
boundary condition: true

metaM caro e
name: beta-carotene
boundary condition: false
has only substance units: false
is: HMDB00561
initial concentration: 1.0
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
initial amount: NaN
type: Species
is: CHEBI:17579
is: SBO:0000247
constant: false

metaM ksii core2 deg1 l
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
initial concentration: 1.0
constant: false
name: keratan sulfate II (core 2-linked), degradation product 1
is: CHEBI:57737
initial amount: NaN
is: HMDB00868
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaR 4HOXPACDOX NADP
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110059#

metaM datp c
initial concentration: 1.0
is: SBO:0000247
is: HMDB01532
type: Species
constant: false
is: C00131
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
name: dATP
boundary condition: false
initial amount: NaN
is: CHEBI:61404

metaM fe2 c
is: CHEBI:29033
type: Species
initial amount: NaN
is: SBO:0000247
is: C00023
constant: false
is: HMDB00692
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Fe2+

metaR RBTt
is: SBO:0000185
fast: false
product: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
name: ribitol transport via passive diffusion
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is described by: ECO:0000000
type: Reaction

metaM prostgd2 c
boundary condition: false
constant: false
is: CHEBI:57406
name: prostaglandin D2(1-)
type: Species
is: HMDB01403
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM docohexcoa x
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
name: 2,4,7,10,13,16-docosahexenoylcoa
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4

metaR GLUDxm
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110059#
is described by: ECO:0000269
product: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110059#
name: glutamate dehydrogenase (NAD) (mitochondrial)

http://identifiers.org/biomodels.db/MODEL1310110059#_0df6bc01_9e09_4095_a77a_08a1b1c15074
initial amount: NaN
type: Species
has only substance units: false
constant: false
has part: Q9UN42
is encoded by: hsa:23439
has part: P50993
is: SBO:0000297
is encoded by: hsa:477
initial concentration: NaN
boundary condition: true
name: ATP1B4:ATP1A2

metaM 3hddcoa c
name: (S)-3-Hydroxydodecanoyl-CoA
is: HMDB00623
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_35e8311c_61fd_493d_acf9_edca8969ca57
is encoded by: hsa:3030
initial amount: NaN
has only substance units: false
is: E9KL44
name: HADHA
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR r1621
reactant: MODEL1310110059#
fast: false
type: Reaction
kinetic law: MODEL1310110059#
reversible: true
is: SBO:0000185
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110059#

metaR ACCOAC
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM sbt D c
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: CHEBI:17924
name: D-glucitol
is: HMDB00247
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

metaM 3dpdhb me m
type: Species
boundary condition: false
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
is: CHEBI:50776
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+

http://identifiers.org/biomodels.db/MODEL1310110059#_c2105f9a_b1f9_4120_817d_30937eba4c76
is encoded by: hsa:5476
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: P10619
has only substance units: false
name: CTSA
type: Species

metaR r1466
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
type: Reaction
name: EC:2.3.1.86

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_5582b06c_ead9_4f09_a8e6_9466334b3c8d
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5295
has part: E7EX19
is: SBO:0000297
name: PIK3CD:PIK3R1

metaM tetdecdicoa m
is: HMDB02288
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: 5,8-tetradecadienoylcoa
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_85bd02e6_eada_4d04_a956_7475e5298b60
name: PIGF
initial amount: NaN
is: Q07326
initial concentration: NaN
is encoded by: hsa:5281
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_5e6bbde5_86fa_4c26_8be5_0e2ac3d28690
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q6IBK2
is encoded by: hsa:3795
name: KHK
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaM HC02203 c
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:27820
is: SBO:0000247
name: prostaglandin-a2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
type: Species
initial concentration: 1.0

metaR r1620
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_edd7f3e2_6c25_4276_aed5_2c5d83920645
is: P11168
is encoded by: hsa:6514
name: SLC2A2
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM ddeccrn c
initial concentration: 1.0
initial amount: NaN
is: HMDB02250
boundary condition: false
name: lauroyl carnitine
is: SBO:0000247
notes: FORMULA: C19H37NO4 CHARGE: 0
type: Species
has only substance units: false
constant: false

metaR DOLPGT1 Ler
is: SBO:0000176
type: Reaction
modifier: MODEL1310110059#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reversible: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.267
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110059#
is described by: ECO:0000000
fast: false

metaR ASCBt
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110059#
reversible: true
is: SBO:0000185
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
name: L-ascorbate transport via facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD

metaR RE3346C
reversible: true
name: RE3346
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false

metaM ksi deg18 l
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
boundary condition: false
name: keratan sulfate I, degradation product 18
is: CHEBI:12936
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00143
initial amount: NaN

metaR URCN
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.49
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
name: URCN
type: Reaction
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR PPPG9tm
product: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
name: protoporphyrinogen IX mitochondrial transport
type: Reaction
reactant: MODEL1310110059#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110059#

metaM malt c
initial concentration: 1.0
is: CHEBI:17306
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00208
name: Maltose
is: HMDB00163
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: SBO:0000247
constant: false
type: Species

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR KCC2t
kinetic law: MODEL1310110059#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110059#
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
type: Reaction
modifier: MODEL1310110059#
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_8f71ad68_5df0_4871_95b8_630047747f2a
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4190
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: MDH1
is: B7Z3I7

http://identifiers.org/biomodels.db/MODEL1310110059#_231df9c8_f6a9_494f_ae7e_d06371df20cb
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:270
has only substance units: false
is: P23109
constant: false
name: AMPD1
type: Species
is: SBO:0000252

metaM tetdec2crn e
initial concentration: 1.0
name: tetradecadienoyl carnitine
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H37NO4 CHARGE: 0
is: HMDB05066
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_1765f05c_c2d1_4ca5_b9c7_afadcbae7e66
initial concentration: NaN
is: SBO:0000252
is: Q6LEN5
boundary condition: true
name: CHAT
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:1103

metaM tststerones c
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
is: SBO:0000247
initial amount: NaN
name: testosterone sulfate
is: HMDB02833
type: Species
boundary condition: false

metaM ksi pre21 g
is: HMDB00175
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: C00130
name: keratan sulfate I biosynthesis, precursor 21
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
constant: false
boundary condition: false

metaR GLCAASE7ly
reactant: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176
product: MODEL1310110059#

metaR r1623
product: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CKc
reversible: true
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.3.2
notes: GENE_ASSOCIATION: (1152.1) or (1158.1) and (1152.1) or (1158.1) SUBSYSTEM: Urea cycle EC Number: 2.7.3.2 Confidence Level: 4 AUTHORS: PMID:2883200,PMID:3034271 NOTES:kegg C02305 MJC SAB c
name: ATP Creatine kinase (c)
fast: false
reactant: MODEL1310110059#
modifier: MODEL1310110059#

metaM sbt D e
boundary condition: false
is: HMDB00247
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
name: D-glucitol
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR RE2426C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
reversible: true
name: RE2426
is: SBO:0000176
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction

metaR S6TASE11ly
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110059#_43ed550e_d2e2_43f7_80c6_98ca3c005c46
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is: P28331
is encoded by: hsa:4719
name: NDUFS1
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR TETTET6COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110059#
fast: false
name: fatty acid intracellular transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_b581a716_3a9a_46d1_a520_2c3f34cd236f
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: P35475
initial amount: NaN
name: IDUA
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3425

metaM 3hbcoa R m
has only substance units: false
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
constant: false
name: (R)-3-hydroxybutanoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57315
initial amount: NaN
is: SBO:0000247
is: HMDB01166

metaM ddeccrn e
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C19H37NO4 CHARGE: 0
has only substance units: false
name: lauroyl carnitine
is: SBO:0000247
is: HMDB02250
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1e511db3_5baa_423a_bd3a_cc898e2424f0
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: AMY1A
type: Species
is encoded by: hsa:276
boundary condition: true
constant: false
initial amount: NaN
is: Q6NSB3

metaM slfcys e
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: C05824
is: HMDB00731
name: S-Sulfo-L-cysteine
is: SBO:0000247
notes: FORMULA: C3H8NO5S2 CHARGE: -1

metaM alpro m
has only substance units: false
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
is: CHEBI:16882
is: SBO:0000247
name: S-Aminomethyldihydrolipoylprotein
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

metaR r1622
is described by: ECO:0000000
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110059#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110059#_7ddd0469_a93d_4ac9_b436_675115db8764
type: Species
boundary condition: true
constant: false
name: PDE1C
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5137
is: SBO:0000252
is: Q8NB10

metaR UGLCNACtg
type: Reaction
is: SBO:0000185
reactant: MODEL1310110059#
name: UDP-GlcNAc Golgi transport via CMP antiport
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false
is described by: ECO:0000269

metaM hpdca c
is: HMDB02259
is: CHEBI:32366
boundary condition: false
constant: false
initial amount: NaN
name: margarate
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_c9eba8c6_0cd1_4d57_badd_3fdbc7b6bbe7
name: HCST:PIK3CG
initial amount: NaN
has part: Q9UBK5
is: SBO:0000297
is encoded by: hsa:5294
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has part: P48736
has only substance units: false
is encoded by: hsa:10870

metaR NODe
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reversible: true
name: NODe

metaR RTOTALt
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
name: RTOTAL transport
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
reversible: true

metaR GLNTHRNaEx
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110059#
type: Reaction
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
fast: false
modifier: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#

metaM fe2 m
is: CHEBI:29033
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: HMDB00692
is: C00023
initial amount: NaN
name: Fe2+
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR NADS2
reversible: false
reactant: MODEL1310110059#
product: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.1
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
name: NAD synthase (glutamine-hydrolysing)
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_deb4c04a_5fb4_4a29_a4eb_d08ad989786c
initial amount: NaN
name: PDE9A
initial concentration: NaN
is encoded by: hsa:5152
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_d88d9776_a17f_41e4_bf8e_2fb9f19a36ed
is encoded by: hsa:6799
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: SULT1A2
constant: false
has only substance units: false
initial amount: NaN

metaM ahdt e
initial amount: NaN
constant: false
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
is: HMDB00980
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58462
initial concentration: 1.0

metaR r1624
type: Reaction
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_683e19b1_c03d_426a_8d72_bfff2f1292a7
is: SBO:0000252
is encoded by: hsa:10195
name: ALG3
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_129a3191_8124_40ba_9518_4e2fb26d59dc
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: D9HTE9
name: SLC25A1
is encoded by: hsa:6576
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_05741ee3_be59_41a4_9b6b_a8bc0c43a3d8
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SCD
is: SBO:0000252
is: O00767
is encoded by: hsa:6319

http://identifiers.org/biomodels.db/MODEL1310110059#_da6e327e_52f0_4196_810d_547352a07bbb
constant: false
has only substance units: false
is encoded by: hsa:11182
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC2A6
is: Q9UGQ3
initial concentration: NaN
type: Species

metaR NDP7er
kinetic law: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

metaM L2aadp m
is: CHEBI:58672
is: HMDB00510
is: SBO:0000247
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
name: L-2-aminoadipate(1-)
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR TETDECE1CRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR r0698
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is version of: http://identifiers.org/ec-code/3.1.2.27
modifier: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:

metaR O2tm
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is: SBO:0000185
name: O2 transport (diffusion)
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_12b4de5f_4f7e_4422_b461_bcfb9e341696
is: SBO:0000252
type: Species
name: _R39999_1_c
is encoded by: hsa:R39999
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r1318
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185
name: Transport reaction
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaM cys L c
constant: false
is: SBO:0000247
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561
name: L-cysteine
initial amount: NaN
is: HMDB00574
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaM ser L e
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
is: HMDB00187
name: L-serine

metaM ksii core2 pre3 g
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 3
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
is: C00130
constant: false

W3 CDTF: Fri Aug 31 02:23:00 BST 2012

metaR ALAASNNaEx
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
is: SBO:0000185
fast: false

metaR NRVNCt
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
product: MODEL1310110059#
is described by: ECO:0000000
fast: false

metaM HC00361 c
type: Species
boundary condition: false
is: CHEBI:58335
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: sedoheptulose 1,7-bisphosphate(4-)
is: SBO:0000247
constant: false

metaR r1625
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000000

metaR FAOXC225x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaM etfox m
name: Electron transfer flavoprotein oxidized
notes: FORMULA: R CHARGE: 0
type: Species
is: HMDB00145
boundary condition: false
is: CHEBI:17263
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1f15703c_22ac_4583_9619_51abbb2483f5
constant: false
is: Q4KWH8
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: PLCH1
is encoded by: hsa:23007
boundary condition: true
initial concentration: NaN

metaM 4abut e
is: CHEBI:3628
name: 4-Aminobutanoate
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
is: SBO:0000247
is: HMDB00112
boundary condition: false
has only substance units: false

metaR RE2626M
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
type: Reaction
reversible: true
name: RE2626
is: SBO:0000176
kinetic law: MODEL1310110059#

metaM hpdca e
is: CHEBI:32366
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: margarate
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: HMDB02259
type: Species
initial concentration: 1.0
has only substance units: false

metaM 3dhguln c
initial amount: NaN
is: CHEBI:57655
boundary condition: false
initial concentration: 1.0
name: 3-dehydro-L-gulonate
constant: false
is: HMDB06334
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
type: Species

metaM memgacpail hs r
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:15809
initial amount: NaN
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_42514fbe_0ab0_4510_8102_0465569e2439
name: SLC7A11
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9UPY5
is encoded by: hsa:23657
boundary condition: true
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_ccd225ef_2fa8_4403_af29_0357ebc942e0
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2203
name: FBP1
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q2TU34

http://identifiers.org/biomodels.db/MODEL1310110059#_c0c06c94_b3e7_4416_8b14_e17356aacc0b
is: SBO:0000252
initial concentration: NaN
name: ACSS1
type: Species
is: Q9NUB1
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:84532

http://identifiers.org/biomodels.db/MODEL1310110059#_f426eb61_495b_4a5a_839c_d1ecc6f90503
is encoded by: hsa:AI990637
has only substance units: false
name: _AI990637_1_x
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaR r0954
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
reactant: MODEL1310110059#
name: MCT 1 Transport reaction
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#

metaM odecoa r
is: CHEBI:57387
is: HMDB01322
has only substance units: false
is: SBO:0000247
name: oleoyl-CoA(4-)
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
type: Species
initial amount: NaN

metaR 4HBZCOAFm
is: SBO:0000176
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: 4-hydroxybenzoyl-CoA formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reactant: MODEL1310110059#
type: Reaction
fast: false

metaR r1626
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: true

metaR GLCter
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD

metaM hxcoa c
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
name: Hexanoyl-CoA (n-C6:0CoA)
is: HMDB13130

metaM HC01496 m
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
name: 2-Amino-3-oxoadipate
is: SBO:0000247
is: CHEBI:28095
has only substance units: false
initial amount: NaN

metaR C4tcx
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaR S6TASE1ly
modifier: MODEL1310110059#
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
kinetic law: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#

metaR AG13T3g
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
reactant: MODEL1310110059#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_93c26694_b5d6_490b_845b_5de7e861e476
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ALDH9A1
is: P49189
is encoded by: hsa:223
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR 4NPHSULT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is described by: ECO:0000269
name: 4-Nitrophenol Sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.1
is: SBO:0000176
reversible: false

metaM ser L c
is: HMDB00187
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17115
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
name: L-serine

metaR C6DCCACT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaR r1627
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110059#_2d1199a5_aa2d_40f0_b5a0_21cceb15eb52
initial amount: NaN
constant: false
is encoded by: hsa:52
is: P24666
boundary condition: true
type: Species
name: ACP1
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR C141ACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaM formcoa c
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57376
initial amount: NaN
constant: false
name: formyl-CoA(4-)
is: HMDB03419
type: Species

metaM tetpent6coa x
is: C16172
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-6
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
constant: false

metaM dcyt n
initial amount: NaN
name: 2'-deoxycytidine
is: CHEBI:15698
boundary condition: false
is: HMDB00014
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaR O2tp
reactant: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, peroxisomal
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ef36d764_b1f6_4ddf_9403_be3f883466cf
initial amount: NaN
name: HAGHL
constant: false
is encoded by: hsa:84264
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR FAOXC201C181x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_8dd1297e_ddbd_477e_aa75_bec0d4e3279e
constant: false
is encoded by: hsa:220
initial concentration: NaN
is: P47895
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: ALDH1A3
has only substance units: false

metaR r0097
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
reactant: MODEL1310110059#
reversible: false
is described by: ECO:0000000
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
kinetic law: MODEL1310110059#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_b9973402_f2a8_4356_9b3a_9c2e4805d142
is: SBO:0000252
boundary condition: true
constant: false
name: RDH8
is: Q9NYR8
type: Species
is encoded by: hsa:50700
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r1628
is described by: ECO:0000000
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
reversible: true
fast: false
type: Reaction
is: SBO:0000185

metaR S6TASE18ly
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction

W3 CDTF: Fri Aug 31 02:23:00 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110059#_3f1b6f77_bbb9_4e84_ae3c_bab3ae4845ed
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: EGFL8
is encoded by: hsa:80864
constant: false
is: Q99944
initial concentration: NaN
has only substance units: false

metaR SMS
is: SBO:0000176
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.8.27
name: Sphingomyelin synthase (homo sapiens)
product: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reversible: false

metaM ksi pre8 g
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 8
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
is: CHEBI:28067
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_d1209721_04da_4f59_90e2_987550a48819
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4846
is: SBO:0000252
name: NOS3
initial concentration: NaN
initial amount: NaN
is: A0S0A7
has only substance units: false

metaM apoC Lys m
has only substance units: false
is: CHEBI:32551
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
name: Apocarboxylase (Lys residue)
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00182
type: Species

metaM dolmanp U c
initial amount: NaN
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog
boundary condition: false
is: CHEBI:15809
initial concentration: 1.0
constant: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
has only substance units: false

metaR B MANNASEly
is version of: http://identifiers.org/ec-code/3.2.1.25
type: Reaction
product: MODEL1310110059#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
name: beta-mannosidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD

metaR GALASE19ly
name: beta-galactosidase, lysosomal
is described by: ECO:0000269
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR r1629
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
fast: false

metaM c6dc c
constant: false
is: HMDB00705
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C13H22NO6 CHARGE: -1
boundary condition: false
has only substance units: false
name: adipoyl carnitine
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_ac8460b5_6aa0_4358_9086_40fc159fc069
constant: false
boundary condition: true
name: COX4I2
initial concentration: NaN
initial amount: NaN
is: Q96KJ9
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84701

metaM 5oxpro e
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: HMDB00267
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: 5-oxoprolinate
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57606

orgname: University of Manchester

http://identifiers.org/biomodels.db/MODEL1310110059#_fbe3c257_59d6_4b87_a723_023a7a3ae3d2
initial amount: NaN
constant: false
name: PLCB1
is encoded by: hsa:23236
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR O2tn
fast: false
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 nuclear transport
reversible: true
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaM odecoa m
is: HMDB01322
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Octadecenoyl-CoA (n-C18:1CoA)
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: CHEBI:57387
initial amount: NaN

metaR INSt
fast: false
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000269
name: Inosine transport (diffusion)
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
is: SBO:0000185
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
reversible: true

metaR NAt5
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000269
name: sodium/ammonium proton antiporter
product: MODEL1310110059#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6548.1) or (6550.1) or (6549.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:8199403,PMID:8595899 NOTES:NCD
is: SBO:0000185
fast: false

metaM HC02121 c
initial amount: NaN
name: S-(hydroxymethyl)glutathione(1-)
has only substance units: false
is: CHEBI:58758
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
initial concentration: 1.0

metaM prist c
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00795
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:51340
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
constant: false
name: pristanic acid
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_9cbef503_fbdc_42b9_82a3_55604fb7c7b4
name: HIBADH
initial amount: NaN
is encoded by: hsa:11112
type: Species
constant: false
is: P31937
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_13f60652_d7e2_4793_95dd_75abe82f087e
initial amount: NaN
is: SBO:0000252
type: Species
is: Q8NFW8
initial concentration: NaN
is encoded by: hsa:55907
name: CMAS
has only substance units: false
boundary condition: true
constant: false

W3 CDTF: Fri Aug 31 02:23:00 BST 2012

metaR GDPtg
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: GDP intracellular transport
fast: false

metaR PI45P4P
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110059#_304d8ba5_e312_4dcd_8016_77ef5d5785cb
has only substance units: false
boundary condition: true
constant: false
name: AK4
is encoded by: hsa:205
type: Species
initial concentration: NaN
is: SBO:0000252
is: P27144
initial amount: NaN

metaR NDP7ex
modifier: MODEL1310110059#
reversible: false
fast: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000176
product: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
name: nucleoside-diphosphatase (UDP), extracellular

metaR AG13T11g
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_e75009eb_6d2a_4a83_9f42_2346ec4d27ad
initial amount: NaN
name: ACOT2
is: P49753
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:10965

metaM idp c
constant: false
is: CHEBI:58280
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
initial amount: NaN
name: IDP(3-)
is: HMDB03335
type: Species

metaM 4abut c
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: 4-Aminobutanoate
initial amount: NaN
is: CHEBI:3628
is: C00334
is: HMDB00112
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
initial concentration: 1.0

metaM 3pg m
is: SBO:0000247
is: CHEBI:58272
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: HMDB00807
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate

http://identifiers.org/biomodels.db/MODEL1310110059#_d0c34ed0_0c5b_4575_8b88_482bf037b003
constant: false
has only substance units: false
boundary condition: true
type: Species
name: DPAGT1
is: SBO:0000252
is encoded by: hsa:1798
initial concentration: NaN
initial amount: NaN

W3 CDTF: Fri Aug 31 02:23:00 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110059#_0753ceba_3b17_491e_8879_aa4684a9722a
name: PDE6H
initial amount: NaN
is: Q13956
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5149
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaR NDPK1n
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110059#
is described by: ECO:0000134
modifier: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#

metaM crn c
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00062
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
constant: false
name: L-Carnitine
is: CHEBI:16347
is: C00318

metaM 3hbcoa R c
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
constant: false
initial concentration: 1.0
initial amount: NaN
name: (R)-3-hydroxybutanoyl-CoA(4-)
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01166

metaM rbt e
type: Species
is: HMDB00508
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
is: SBO:0000247
initial amount: NaN
is: CHEBI:15963
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM 3hdececrn e
notes: FORMULA: C23H43NO5 CHARGE: 0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: 3-hydroxyhexadecenoylcarnitine
is: HMDB12930
has only substance units: false

metaR NACHEX24ly
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM dmgly c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:17724
is: HMDB00092
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7) EHMN_ABBREVIATION: C01026
name: N,N-dimethylglycine

metaM arab L e
initial concentration: 1.0
is: HMDB00646
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:30849

http://identifiers.org/biomodels.db/MODEL1310110059#_4bd83f4f_8c53_4f73_bdc9_43feab113a62
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q9H310
name: RHBG
type: Species
initial concentration: NaN
is encoded by: hsa:57127
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_6b405f01_cd0f_4d16_bc3a_d4bc1d97d36a
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:1384
name: CRAT
type: Species
initial amount: NaN
initial concentration: NaN

metaR FAOXC150m
is: SBO:0000176
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
kinetic law: MODEL1310110059#

metaM tyr L e
is: CHEBI:17895
boundary condition: false
name: L-tyrosine
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
is: HMDB00158
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_db0c53e6_d997_483c_9db0_6fc96248288b
initial amount: NaN
is encoded by: hsa:29922
is: Q9Y5B8
name: NME7
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR RE2814M
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110059#
name: RE2814
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_293b85b7_e679_4395_9ee0_d3228813c027
is: SBO:0000297
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: EHHADH:ACAA1:HSD17B4:ACOX3
constant: false
is encoded by: hsa:8310
has part: O15254

metaM pail4p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN
is: CHEBI:58178
initial concentration: 1.0
has only substance units: false

metaM CE2416 x
type: Species
constant: false
name: (2R,6S,10S)-pristanate
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110059#_c4303925_8f41_4d10_a9d2_348b0ad52068
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALG8
is: Q9BVK2
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:79053

metaM docohexcoa m
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: 2,4,7,10,13,16-docosahexenoylcoa
initial concentration: 1.0

metaR FAOXC5C5OHm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR 3MOPt2im
fast: false
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000185
reversible: false
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110059#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110059#_cb7101ea_8eff_489d_b810_0f5a79d3c4de
type: Species
is: SBO:0000252
is: P51160
boundary condition: true
name: PDE6C
has only substance units: false
is encoded by: hsa:5146
initial concentration: NaN
initial amount: NaN
constant: false

metaR O2ter
kinetic law: MODEL1310110059#
name: O2 transport, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM dhlpro m
name: Dihydrolipolprotein
is: CHEBI:16194
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_73052bb6_fbe7_4842_a678_60fbce892654
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: PDE9A
initial amount: NaN
type: Species

metaR NDPK1m
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110059#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
fast: false
product: MODEL1310110059#

metaM tymsf c
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: HMDB06409
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: Tyramine O-sulfate
initial amount: NaN

metaR SBT Dtde
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reactant: MODEL1310110059#
name: D-sorbitol transport, extracellular
reversible: true
fast: false

metaM idp e
is: CHEBI:58280
is: SBO:0000247
has only substance units: false
name: IDP(3-)
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

metaR THRSERNaEx
kinetic law: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
fast: false
modifier: MODEL1310110059#
is: SBO:0000185

metaR r1738
modifier: MODEL1310110059#
reactant: MODEL1310110059#
reversible: false
is: SBO:0000185
product: MODEL1310110059#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110059#

metaR PAIL4P HStn
reactant: MODEL1310110059#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
product: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_f16a24bd_75ac_4644_a9a1_f70d5ef9bb79
initial amount: NaN
is encoded by: hsa:10935
has only substance units: false
name: PRDX3
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: E9PH29

metaR PI5P3K
product: MODEL1310110059#
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.154
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-5-phosphate 3-kinase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
reactant: MODEL1310110059#

metaR P45011A1m
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: Cytochrome P450 11A1, mitochondrial [Precursor]
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.15.6
reversible: false
type: Reaction

metaM val L m
boundary condition: false
has only substance units: false
initial amount: NaN
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
initial concentration: 1.0
is: CHEBI:16414
is: HMDB00883
constant: false
is: SBO:0000247

metaR PEAMNO
is described by: ECO:0000304
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110059#
reactant: MODEL1310110059#
name: Phenethylamine oxidase
fast: false
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
type: Reaction
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.4.3.4
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.21

http://identifiers.org/biomodels.db/MODEL1310110059#_ec556f10_680f_4cf5_a917_de7c0745aa0f
initial concentration: NaN
name: ECI2
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10455
is: O75521

metaM focytC m
initial amount: NaN
boundary condition: false
is: CHEBI:16928
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
has only substance units: false
name: Ferrocytochrome C

metaM hmbil c
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01137
name: Hydroxymethylbilane
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
is: C01024
boundary condition: false
is: CHEBI:57845

metaM 3hdececrn c
notes: FORMULA: C23H43NO5 CHARGE: 0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: 3-hydroxyhexadecenoylcarnitine
initial concentration: 1.0
has only substance units: false
is: HMDB02014

metaM crn e
is: SBO:0000247
boundary condition: false
is: HMDB00062
type: Species
constant: false
has only substance units: false
is: C00318
initial concentration: 1.0
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
initial amount: NaN

given: Neil
family: Swainston

metaR GLYt7 211 r
fast: false
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110059#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110059#_5be2078f_29a2_444e_abfe_1b35510802d1
name: FUT8
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:2530
is: Q546E0
initial concentration: NaN
initial amount: NaN

metaM rbt c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
is: CHEBI:15963
type: Species
initial amount: NaN
is: HMDB00508
constant: false
initial concentration: 1.0
has only substance units: false

metaR HMGCOAtm
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
product: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD

metaM tyr L c
type: Species
name: L-tyrosine
constant: false
boundary condition: false
is: CHEBI:17895
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
is: SBO:0000247
is: HMDB00158
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_270937c8_4d6d_4a1a_8f65_514cc7e4ff14
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6487
name: ST3GAL3
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_44096646_9da9_40b8_a5f3_d1b452ce1110
name: RDH14
constant: false
is encoded by: hsa:57665
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: Q9HBH5

metaR S6T16g
product: MODEL1310110059#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110059#

metaR 3MOPte
is: SBO:0000185
name: Transport of 3-methyl-2-oxopentanoate
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaM arab L c
boundary condition: false
initial amount: NaN
name: L-arabinose
is: HMDB00646
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0
is: SBO:0000247
is: CHEBI:30849

metaR It
fast: false
modifier: MODEL1310110059#
name: Iodide uniport
is described by: ECO:0000269
type: Reaction
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
kinetic law: MODEL1310110059#
reversible: true
is: SBO:0000185
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_576f4604_a2e1_47d0_a8fa_0c16b8488e4b
name: SLC6A5
is encoded by: hsa:9152
is: Q9Y345
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_05739690_4f50_44ec_9302_7cdd927929b5
type: Species
is: P49915
name: GMPS
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8833
initial concentration: NaN
initial amount: NaN

metaM thyox L e
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247
is: HMDB00248
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: L-thyroxine
constant: false
is: CHEBI:18332

metaM 5oxpro c
initial amount: NaN
is: HMDB00267
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 5-oxoprolinate
is: CHEBI:57606
boundary condition: false
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879

http://identifiers.org/biomodels.db/MODEL1310110059#_23f0e255_5207_4f7d_8e45_8d4a5a9d5f4b
initial amount: NaN
is: SBO:0000252
name: CYP27A1
is encoded by: hsa:1593
has only substance units: false
constant: false
boundary condition: true
is: Q02318
type: Species
initial concentration: NaN

metaR ME2m
name: malic enzyme (NADP), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.40
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
product: MODEL1310110059#
reactant: MODEL1310110059#

metaM hxcoa m
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: HMDB06522
name: Hexanoyl-CoA (n-C6:0CoA)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_16991b33_0930_4b07_9b57_95a5bdd1d6f8
initial concentration: NaN
has only substance units: false
is: Q96I99
constant: false
boundary condition: true
initial amount: NaN
name: SUCLG2
is: SBO:0000252
is encoded by: hsa:8801
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_24554b3d_eddd_4511_8c3c_be31bc2135c0
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: P32321
has only substance units: false
is encoded by: hsa:1635
name: DCTD

metaM mal L c
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15589
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_cc2cb453_b83f_4fd1_ac00_3eb6dd84fce3
name: SLC4A10
is: SBO:0000252
is: B7Z1R0
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:57282
initial amount: NaN
constant: false

metaM 3aib m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
has only substance units: false
name: (S)-3-aminoisobutyric acid
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02166
is: CHEBI:33094
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_8910ab0b_3815_46f2_9cbf_4831530ace45
is: B7Z2M9
initial concentration: NaN
name: DGKZ
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:8525
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_0b9c4556_c892_4209_9400_a7a85cae4e57
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: Q8IXK2
constant: false
name: GALNT12
initial amount: NaN
is encoded by: hsa:79695

metaM 4nphsf e
type: Species
is: SBO:0000247
is: CHEBI:35422
is: HMDB06492
constant: false
initial concentration: 1.0
name: 4-Nitrophenyl sulfate
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
boundary condition: false

metaM ethamp c
constant: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: SBO:0000247
is: HMDB00224
type: Species
initial concentration: 1.0
is: CHEBI:58190
has only substance units: false
name: ethamp[c]
boundary condition: false
initial amount: NaN

metaM sphings c
boundary condition: false
name: sphingosine(1+)
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: HMDB00252
has only substance units: false
constant: false
is: CHEBI:57756

http://identifiers.org/biomodels.db/MODEL1310110059#_0c3cbe54_b639_47fe_af8e_806e13f1ca6f
is: P07686
constant: false
name: HEXB
is encoded by: hsa:3074
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaM ala L c
initial concentration: 1.0
constant: false
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: L-alanine
is: HMDB00161
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_09c5bb5e_a7d1_4780_96dd_272065b64ebf
boundary condition: true
is encoded by: hsa:6535
has only substance units: false
is: B4DIA3
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC6A8
is: SBO:0000252
type: Species

metaR SCP22x
type: Reaction
name: Sterol carrier protein 2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
modifier: MODEL1310110059#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.176
reactant: MODEL1310110059#
reversible: true

metaR AIRCr
is version of: http://identifiers.org/ec-code/6.3.2.6
is: SBO:0000176
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: phosphoribosylaminoimidazole carboxylase
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#

metaR GLNS
type: Reaction
name: glutamine synthetase
product: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.15
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110059#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110059#_4a9c3f3b_a88a_4ce7_9f74_c616611801c0
is: P09622
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:1738
initial concentration: NaN
has only substance units: false
name: DLD
is: SBO:0000252
boundary condition: true

metaR r2139
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000185
modifier: MODEL1310110059#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM sarcs m
is: HMDB00271
is: C00213
constant: false
initial amount: NaN
is: CHEBI:15611
name: Sarcosine
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: SBO:0000247

metaM 3sala m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00606
is: CHEBI:61085
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
has only substance units: false
name: 3-sulfino-L-alanine (1-)
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_4ff9fc8e_8610_4308_81eb_c193de0a5841
name: ATP5L
is: O75964
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10632
type: Species
boundary condition: true
is: SBO:0000252

metaM 3pg c
is: CHEBI:58272
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00807
is: http://identifiers.org/pubchem.compound/3497
name: 3-Phospho-D-glycerate
initial concentration: 1.0
has only substance units: false
constant: false
is: C00197

http://identifiers.org/biomodels.db/MODEL1310110059#_86cadba5_5d62_43e0_9a75_4670f990bac3
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: PANK3
boundary condition: true
is: Q9H999
initial concentration: NaN
is encoded by: hsa:79646
initial amount: NaN

metaM mi14p n
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: HMDB00968
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: CHEBI:58282

metaR UMPK7n
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110059#
name: UMP kinase (dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110059#
reversible: true

metaM mal L e
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:15589
is: HMDB00156
name: (S)-malate(2-)
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC161C161OHm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaM HC00229 e
initial concentration: 1.0
type: Species
is: CHEBI:28189
constant: false
name: Isomaltose
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_b014632d_1458_4513_93a5_18c2081da7e7
constant: false
has only substance units: false
name: ATP1B2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:482
boundary condition: true
is: P14415

http://identifiers.org/biomodels.db/MODEL1310110059#_0c0cbb66_ad72_4cab_b016_a1915435e34f
is: SBO:0000252
name: PIGN
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23556
type: Species
boundary condition: true
has only substance units: false

metaR PCHOLPm hs
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: false
fast: false
name: choline phosphatase
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is described by: ECO:0000269

metaM 4nphsf c
type: Species
name: 4-Nitrophenyl sulfate
is: CHEBI:35422
is: HMDB06492
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_0ed7b369_4369_4614_a2c0_836297f90080
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: B4E0V8
is encoded by: hsa:3034
name: HAL

metaR DUDPtn
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: dUDP nuclear transport
reactant: MODEL1310110059#
fast: false
reversible: true

metaM decdp c
type: Species
initial concentration: 1.0
is: HMDB06288
is: SBO:0000247
constant: false
name: all trans Decaprenyl diphosphate
boundary condition: false
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_31e49f93_abe7_4304_8d37_2f1d71dcdfba
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8871
type: Species
is: SBO:0000252
is: O15056
constant: false
boundary condition: true
has only substance units: false
name: SYNJ2

metaM ppa e
name: propionate
type: Species
is: CHEBI:17272
constant: false
is: SBO:0000247
is: HMDB00237
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

http://identifiers.org/biomodels.db/MODEL1310110059#_411800ea_60d2_48cd_bafc_e92b72127390
is: A8K0S7
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2542
has only substance units: false
name: SLC37A4

http://identifiers.org/biomodels.db/MODEL1310110059#_7bd9912b_07ac_430b_9a7d_a7bc93c40ecc
name: _F23536_1_m
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:F23536
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a3d40150_946d_4db4_8484_d3f9264abf09
name: SLC6A9
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6536
is: P48067
boundary condition: true
initial amount: NaN

metaR HISSNAT5tc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM ksi pre22 g
is: CHEBI:58053
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 22
initial amount: NaN
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
boundary condition: false
is: C00130
has only substance units: false
constant: false
is: HMDB00175
initial concentration: 1.0

metaM hyptaur c
is: SBO:0000247
has only substance units: false
is: CHEBI:16668
constant: false
name: Hypotaurine
initial amount: NaN
type: Species
is: HMDB00965
boundary condition: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
initial concentration: 1.0

metaR EX 3tdcrn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaR MALSO4tm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
is described by: ECO:0000269
name: Malate:sulfate antiport, mitochondrial
is: SBO:0000185
type: Reaction
modifier: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR 3HBCDm
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (55268.1) SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:NCD. rat gene that is homologous to the human gene encodes for this activity
is described by: ECO:0000254
product: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
name: 3-hydroxybutyryl-CoA dehydratase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110059#_53e1e66a_ae7b_4a21_b079_0deefc16cde6
initial amount: NaN
is: P17568
name: NDUFB7
constant: false
is encoded by: hsa:4713
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR RE3628M
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
modifier: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110059#
name: RE3628
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_b7f44713_f497_4407_8d7d_79043a0688a7
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2588
name: GALNS
boundary condition: true
is: P34059

metaM lgt S c
is: HMDB01066
is: CHEBI:57474
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
name: (R)-S-lactoylglutathionate(1-)
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_8674307b_21ff_4275_9606_c0380815e008
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ALAS1
type: Species
has only substance units: false
constant: false
is: P13196
boundary condition: true
is encoded by: hsa:211

metaM cys L e
type: Species
constant: false
is: HMDB00574
is: CHEBI:17561
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
name: L-cysteine
initial concentration: 1.0

metaR OCTDECCACT
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR RE1523M
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
reversible: true
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1523
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_1280bcb1_471c_4f7a_8bfc_0ed6d719942c
boundary condition: true
name: NAGA
is: P17050
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4668
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_d738342f_763d_4a91_9c63_dc69633a2cc6
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8527
has only substance units: false
initial concentration: NaN
constant: false
name: DGKD

metaM retn e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: all-trans-retinoate
boundary condition: false
is: HMDB01852
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
type: Species

metaM ksi pre17 g
initial amount: NaN
type: Species
name: keratan sulfate I biosynthesis, precursor 17
constant: false
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM glyc R c
name: D-glycerate
boundary condition: false
has only substance units: false
is: HMDB00139
is: SBO:0000247
is: CHEBI:16659
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

n:
  given: Ines
  family: Thiele

metaR FAOXC22C20x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22-->C20)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_da7231da_f059_46a2_a7ee_2aa2fce34648
is: B4DX62
constant: false
is encoded by: hsa:6487
name: ST3GAL3
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR UAGDP
reversible: false
modifier: MODEL1310110059#
name: UDP-N-acetylglucosamine diphosphorylase
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
fast: false
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.7.23
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000269
reactant: MODEL1310110059#
type: Reaction

metaR r2099
product: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
kinetic law: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110059#
fast: false

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR EX c51crn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_959bbf95_a465_46e7_99ce_23c6557ecf23
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5150
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: Q13946
name: PDE7A
initial amount: NaN

metaR C140CPT1
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_d3666edc_d3ab_4ad2_a5b0_817a850ee0fb
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: E7EX19
initial amount: NaN
name: PIK3R1
is encoded by: hsa:5295
type: Species

metaM CE5101 m
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57795
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_1877ef42_17b7_4c3d_a685_07b086d3a4cb
is encoded by: hsa:9963
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9UHI7
name: SLC23A1

metaR r1743
name: Y+LAT2 Utilized transport
modifier: MODEL1310110059#
is: SBO:0000185
reactant: MODEL1310110059#
type: Reaction
fast: false
reversible: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110059#
is described by: ECO:0000000

metaR C161CRN2t
reactant: MODEL1310110059#
fast: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000185
name: C161 transport into the mitochondria
modifier: MODEL1310110059#

metaR GLYCLTtp
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
name: glycolate transport into peroxisome
kinetic law: MODEL1310110059#
type: Reaction
reversible: false

metaM 3aib c
name: (S)-3-aminoisobutyric acid
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:33094
is: HMDB02166
constant: false
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

metaR THRCYSNaEx
is: SBO:0000185
type: Reaction
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000269
reversible: false

metaM crn m
is: HMDB00062
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
boundary condition: false
initial amount: NaN
is: C00318
name: L-Carnitine
type: Species

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
modifier: MODEL1310110059#

metaM glx c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: glyoxylate
is: HMDB00119
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
type: Species
is: SBO:0000247
is: CHEBI:36655
constant: false

metaM dmgly m
is: CHEBI:17724
constant: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7) EHMN_ABBREVIATION: C01026
is: SBO:0000247
is: HMDB00092
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: N,N-dimethylglycine
has only substance units: false

metaR PEPCKm
product: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
name: Phosphoenolpyruvate carboxykinase (GTP)
type: Reaction
is: SBO:0000176
modifier: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.32
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:

metaR r2098
kinetic law: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110059#_45388b6a_3277_43f2_8ce6_05700b4c4b8f
is: SBO:0000252
is encoded by: hsa:6185
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P04844
constant: false
name: RPN2
boundary condition: true

metaM pchol hs c
boundary condition: false
name: Phosphatidylcholine
is: CHEBI:16110
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN

metaR ILEtec
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000185
product: MODEL1310110059#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110059#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
reversible: true

metaM retn c
type: Species
is: CHEBI:35291
name: all-trans-retinoate
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
initial concentration: 1.0

metaR FAOXC163C164Gm
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaM cgly e
is: HMDB00078
is: SBO:0000247
name: L-cysteinylglycine
constant: false
has only substance units: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: CHEBI:4047
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM 3mox4hpac m
boundary condition: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
is: CHEBI:28111
type: Species
constant: false
has only substance units: false
is: HMDB05175

metaM ivcoa m
is: CHEBI:57345
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
constant: false
name: Isovaleryl-CoA
has only substance units: false
is: HMDB01113
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM 4ppcys c
is: SBO:0000247
constant: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
type: Species
is: CHEBI:59458
initial amount: NaN
initial concentration: 1.0
is: C04352
boundary condition: false
is: HMDB01117
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

metaR EX ddecrn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaR HMGCOAtx
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110059#
type: Reaction
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
kinetic law: MODEL1310110059#
product: MODEL1310110059#

metaM psyltchol e
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB03402
initial concentration: 1.0
type: Species
notes: FORMULA: C9642032H15428745NO8667421S CHARGE: 0
initial amount: NaN
name: psyllium-taurocholic acid complex

http://identifiers.org/biomodels.db/MODEL1310110059#_54823fc0_0866_4faf_beb7_c403e2127ace
has only substance units: false
is: SBO:0000252
is encoded by: hsa:259230
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: SGMS1
initial amount: NaN
is: D3DWC4

metaR C3STDH1r
is described by: ECO:0000134
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.170
reactant: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
reversible: false
is: SBO:0000176
name: C-3 sterol dehydrogenase (4-methylzymosterol)
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ

http://identifiers.org/biomodels.db/MODEL1310110059#_c8159bb8_ab1c_4bf7_8cce_862bcbdd0f09
initial concentration: NaN
is encoded by: hsa:AI091231
constant: false
name: _AI091231_1_c
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR C2tcx
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_97f8881a_ef5c_4d5d_baef_6492b446bc39
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2678
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P19440
type: Species
constant: false
name: GGT1

metaM fru c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: D-Fructose
is: CHEBI:15824
initial concentration: 1.0
type: Species
is: HMDB00660
is: C00095

metaM dcyt c
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
is: HMDB00014
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: C00881
name: Deoxycytidine
is: CHEBI:15698

metaM fru e
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
is: SBO:0000247
initial amount: NaN
is: CHEBI:15824
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: C00095
name: D-Fructose
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_fabc83ec_3c16_41ed_8a30_cb657a01bc86
boundary condition: true
is encoded by: hsa:26289
name: AK5
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q9Y6K8
initial concentration: NaN
type: Species

metaR LCYSTAT
reversible: true
fast: false
modifier: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM
name: L-Cysteate:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
is described by: ECO:0000304

metaR FAOXC1811602m
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid
modifier: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#

metaR r1741
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
is: SBO:0000185
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_136fc26b_7604_4e6f_a7fb_73d06cf0ef93
initial concentration: NaN
type: Species
constant: false
name: ENTPD6
is: SBO:0000252
has only substance units: false
boundary condition: true
is: O75354
is encoded by: hsa:955
initial amount: NaN

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaR DOPAtu
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
reversible: true
name: Dopamine uniport

http://identifiers.org/biomodels.db/MODEL1310110059#_9fdf705d_c00a_45f1_ab85_9d133398ee1b
initial concentration: NaN
name: TKTL1
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:8277
boundary condition: true
is: B7Z7I0

metaM ppa c
is: HMDB00237
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: propionate

http://identifiers.org/biomodels.db/MODEL1310110059#_2a19efa5_3eeb_4e45_971b_e595c7482c95
is encoded by: hsa:8854
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: F5H2Y9
initial concentration: NaN
name: ALDH1A2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_442adc97_e0f5_4c0b_95b1_5b345965b687
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AU149534
name: _AU149534_1_e
constant: false
initial concentration: NaN

metaR BMTer U
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
reversible: false
name: B mannosyltransferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110059#
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_1115db34_a56f_487d_95c9_9d7ebfedf794
name: CA5B
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11238
is: Q9Y2D0
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_1ee5e9d9_8e56_4679_85a1_8ac6c196ecee
is: P56556
name: NDUFA6
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4700
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM 3aib e
has only substance units: false
initial concentration: 1.0
name: (S)-3-aminoisobutyric acid
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:33094
type: Species
is: HMDB02166
initial amount: NaN

metaM pchol hs e
boundary condition: false
name: Phosphatidylcholine
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: CHEBI:16110

metaR MANt1r
product: MODEL1310110059#
reversible: true
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
fast: false
name: mannose transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110059#_34f3bb31_e681_457c_85b5_d661d784fd70
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI620219
initial amount: NaN
boundary condition: true
name: _AI620219_1_m
type: Species

metaR r1740
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_37cdc95c_1008_4ba3_81b6_55944e5b4042
constant: false
has only substance units: false
is encoded by: hsa:AA502753
boundary condition: true
type: Species
is: SBO:0000252
name: _AA502753_1_m
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_04f5fcdb_da5a_4d9e_970a_dc1c4b820c8c
is: P22303
constant: false
is encoded by: hsa:43
name: ACHE
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR EX 3octdece1crn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_ff470996_90b4_4a6f_afcf_fb80e320dde5
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: P50993
type: Species
initial amount: NaN
is encoded by: hsa:477
name: ATP1A2

metaR r0355
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: false
fast: false
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_3bb38d2c_8687_4a7d_853a_24e87cfcb038
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: Q9H999
name: PANK3
is encoded by: hsa:79646
is: SBO:0000252
has only substance units: false

metaM cgly c
type: Species
initial amount: NaN
name: L-cysteinylglycine
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
boundary condition: false
is: CHEBI:4047
is: HMDB00078
is: SBO:0000247

metaR RE2999M
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110059#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE2999
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110059#

metaM drib c
is: HMDB03224
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: CHEBI:28816
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: 2-deoxy-D-ribose
initial concentration: 1.0

metaR ITPtn
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110059#
reversible: true
name: ITP nuclear transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_92b43c71_dbaa_4eb2_8248_cd67777f207d
initial concentration: NaN
is: P07864
constant: false
type: Species
has only substance units: false
is encoded by: hsa:3948
name: LDHC
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR N2M2NMASNtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
name: n2m2nmasn transport, extracellular to lysosome

metaM ctdecdcoa m
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00792
constant: false
name: cis2trans4decadienoylcoa
is: C08277
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110059#_d7a915f2_57c8_4eee_8115_cd71e983b312
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: _AA278423_1_m
is encoded by: hsa:AA278423

metaR FBA
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110059#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000134
reactant: MODEL1310110059#
name: fructose-bisphosphate aldolase
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_9ffbed53_16fe_48ed_93a0_522898b820d8
initial amount: NaN
name: ATP10A
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:57194
boundary condition: true
is: O60312
has only substance units: false
type: Species

metaR FUCASE2ly
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
name: alpha-fucosidase, lysosomal
is: SBO:0000176
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.2.1.51
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_59f12563_5e3c_441c_ae76_eee91a2695e8
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: HADHB
boundary condition: true
is encoded by: hsa:3032
is: P55084
type: Species
initial amount: NaN

metaM leugly c
initial amount: NaN
name: Leucylglycine
initial concentration: 1.0
notes: FORMULA: C8H16N2O3 CHARGE: 0
is: SBO:0000247
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/97364
boundary condition: false
type: Species

metaR CDIPTr
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.8.11
name: phosphatidylinositol synthase (Homo sapiens)
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_10bd6f8c_279d_45b6_8cd9_0f05ec60941e
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6569
initial concentration: NaN
is: Q7Z725
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC34A1

http://identifiers.org/biomodels.db/MODEL1310110059#_fc498c81_f35c_4612_9897_1102023d3ab8
initial concentration: NaN
name: GPI
has only substance units: false
type: Species
boundary condition: true
is: P06744
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2821

http://identifiers.org/biomodels.db/MODEL1310110059#_3cb9882f_ca09_4d82_80d6_e484599449cf
type: Species
is encoded by: hsa:2752
initial concentration: NaN
is: SBO:0000252
name: GLUL
is: P15104
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaM ksii core4 l
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
is: HMDB01644
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
has only substance units: false
type: Species
is: CHEBI:17140

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR KHK
modifier: MODEL1310110059#
type: Reaction
name: ketohexokinase
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.3
reactant: MODEL1310110059#
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_7658d24f_0ed2_4d50_93e2_da483a7616fd
boundary condition: true
name: NOS1
initial amount: NaN
initial concentration: NaN
is: B4DG68
is: SBO:0000252
is encoded by: hsa:4842
constant: false
type: Species
has only substance units: false

metaM drib e
constant: false
is: HMDB03224
boundary condition: false
name: 2-deoxy-D-ribose
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
has only substance units: false
is: CHEBI:28816
type: Species
initial concentration: 1.0

metaR TETTET6t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110059#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110059#
name: fatty acid transport via diffusion

metaR Coqe
kinetic law: MODEL1310110059#
name: Transport of q10
reactant: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000134
fast: false
reversible: true
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_a2f1a235_a645_4f36_8e62_8700b78810ac
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC25A16
is encoded by: hsa:8034
is: P16260
boundary condition: true

metaM kynate c
type: Species
has only substance units: false
name: kynurenate
is: CHEBI:58454
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: SBO:0000247
constant: false
is: HMDB00715
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR UPP3S
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/4.2.1.75
product: MODEL1310110059#
type: Reaction
name: uroporphyrinogen-III synthase
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110059#

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_8cc3adf1_8adc_4560_94ab_ab8cfe0f0071
boundary condition: true
is encoded by: hsa:1718
name: DHCR24
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q15392
constant: false

metaM na1 r
initial amount: NaN
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
boundary condition: false
is: HMDB00588
constant: false
is: SBO:0000247
is: CHEBI:29101
initial concentration: 1.0
has only substance units: false
type: Species
name: sodium(1+)

metaM acald e
has only substance units: false
constant: false
name: acetaldehyde
boundary condition: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial amount: NaN
is: SBO:0000247
is: CHEBI:15343
is: HMDB00990
initial concentration: 1.0
type: Species

metaR PNTK
product: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000269
type: Reaction
name: pantothenate kinase
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110059#
reversible: false
is: SBO:0000176
modifier: MODEL1310110059#

metaR r0509
type: Reaction
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110059#
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:

metaR FAOXC81C61m
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR FACOAL246 1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
is: SBO:0000176
name: fatty-acid--CoA ligase
reversible: true
fast: false

metaR r0354
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
reversible: false
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false

metaR FAOXC5C3x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaR ARGtm
kinetic law: MODEL1310110059#
name: arginine mitochondrial transport via ornithine carrier
reversible: true
is described by: ECO:0000269
product: MODEL1310110059#
modifier: MODEL1310110059#
is: SBO:0000185
fast: false
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR HDCACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_21554184_0087_4747_aafa_8abce229823a
is: P40394
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:131
name: ADH7
initial concentration: NaN

metaM leugly e
is: SBO:0000247
name: Leucylglycine
initial concentration: 1.0
notes: FORMULA: C8H16N2O3 CHARGE: 0
constant: false
is: http://identifiers.org/pubchem.compound/97364
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_961a54ad_677e_415b_b62e_b868c0326b8e
constant: false
has only substance units: false
name: DEGS1
initial concentration: NaN
is encoded by: hsa:8560
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_b4f862b7_0f89_42a7_b17e_08f1b50dbd23
constant: false
initial amount: NaN
initial concentration: NaN
name: ALPI
is encoded by: hsa:248
type: Species
has only substance units: false
boundary condition: true
is: P09923
is: SBO:0000252

metaM decdp m
boundary condition: false
is: HMDB06288
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
initial concentration: 1.0
name: all trans Decaprenyl diphosphate

metaR r0249
type: Reaction
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
product: MODEL1310110059#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:

metaR FACOAL206
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
fast: false
is: SBO:0000176
reversible: true

metaM xolest2 hs e
boundary condition: false
initial amount: NaN
name: cholesterol ester
is: CHEBI:17002
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0

metaR GPIMTer L
kinetic law: MODEL1310110059#
reversible: false
reactant: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
is described by: ECO:0000000
type: Reaction
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
is: SBO:0000176
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_64d72808_5bf0_4608_8bbc_e07e2891d872
boundary condition: true
has only substance units: false
constant: false
name: _2509_1_e
is: SBO:0000252
is encoded by: hsa:2509
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_bbe197cc_5ec4_4824_a601_6661fdbe6f8e
type: Species
is: P54819
is: SBO:0000252
has only substance units: false
name: AK2
initial concentration: NaN
is encoded by: hsa:204
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_1b254f3c_d0c1_4309_9b36_a4672148f6ab
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10400
name: PEMT
type: Species
initial concentration: NaN
is: Q9UBM1
has only substance units: false
constant: false
boundary condition: true

metaR G6PDH1rer
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
reversible: true
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum

metaM Lcyst c
name: L-cysteate(1-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB02757
boundary condition: false
is: CHEBI:58090
type: Species
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506

metaM acald c
is: HMDB00990
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
is: CHEBI:15343
type: Species
name: acetaldehyde
constant: false
is: SBO:0000247

metaR TSTSTERONESte
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
type: Reaction
name: sulfonated testosterone transport
reactant: MODEL1310110059#
is described by: ECO:0000000
product: MODEL1310110059#
fast: false
is: SBO:0000185

metaM ksii core4 g
has only substance units: false
is: CHEBI:17140
constant: false
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
is: HMDB01644
boundary condition: false
is: SBO:0000247

metaR RE2954C
reactant: MODEL1310110059#
type: Reaction
name: RE2954
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
is: SBO:0000176
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_06e341d2_efb5_491e_98e3_73588ec21e14
has only substance units: false
is encoded by: hsa:65263
initial concentration: NaN
is: Q53H96
is: SBO:0000252
name: PYCRL
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaR FAOXC81C61x
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaM crvnc e
is: CHEBI:36005
is: HMDB02183
initial amount: NaN
notes: FORMULA: C22H31O2 CHARGE: -1
type: Species
boundary condition: false
initial concentration: 1.0
name: cervonic acid, C22:6 n-3
is: SBO:0000247
has only substance units: false
constant: false

metaM m3mpdol L c
constant: false
is: SBO:0000247
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
is: CHEBI:37632
has only substance units: false
initial amount: NaN
type: Species

metaR r0246
type: Reaction
is: SBO:0000176
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false
kinetic law: MODEL1310110059#
product: MODEL1310110059#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2

metaR CYSGLYexR
type: Reaction
product: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
reactant: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
reversible: true
fast: false
kinetic law: MODEL1310110059#
name: L-cysteine/glycine reversible exchanger

metaM C02470 c
constant: false
is: HMDB00881
initial concentration: 1.0
boundary condition: false
name: Xanthurenic acid
is: SBO:0000247
type: Species
has only substance units: false
is: C02470
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: http://identifiers.org/pubchem.compound/5485
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_dea5ab6e_d591_4fa7_9251_e4b7fb53dfd7
name: LSS
constant: false
is: E9PEI9
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4047
initial concentration: NaN
type: Species
boundary condition: true

metaM pmtcoa x
initial amount: NaN
is: SBO:0000247
is: C00154
type: Species
boundary condition: false
has only substance units: false
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: CHEBI:57379
is: HMDB01338
initial concentration: 1.0

metaR r1631
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#

metaM na1 c
initial amount: NaN
is: C01330
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
initial concentration: 1.0
name: Sodium
constant: false
type: Species
is: CHEBI:4541
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM 3sala c
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:61085
name: 3-Sulfino-L-alanine
is: SBO:0000247
is: C00606
initial amount: NaN
has only substance units: false
constant: false

metaR FACOAL205
reactant: MODEL1310110059#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
product: MODEL1310110059#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110059#

metaM 4ppcys m
constant: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:59458
is: SBO:0000247
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
has only substance units: false
is: HMDB01117
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_2f2100d9_d4bf_409b_8071_100dfb596e3e
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:1633
is: P27707
constant: false
is: SBO:0000252
name: DCK

metaR r0504
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_fdd5aa41_1130_4430_a25a_fed8b435fb60
type: Species
boundary condition: true
is encoded by: hsa:27165
name: GLS2
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM tdcrn e
is: HMDB05066
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C21H41NO4 CHARGE: 0
is: SBO:0000247
name: myristoyl carnitine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_c84a8f4e_3b4f_4370_9a5e_73ca1a1beee9
is encoded by: hsa:6647
is: P00441
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
name: SOD1

metaR EHGLATm
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
type: Reaction
is described by: ECO:0000212
kinetic law: MODEL1310110059#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
reversible: false

metaM c51crn e
is: SBO:0000247
has only substance units: false
is: HMDB02366
type: Species
initial amount: NaN
name: tiglyl carnitine
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C12H21NO4 CHARGE: 0

metaR DECDPtm
kinetic law: MODEL1310110059#
reversible: true
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
product: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_49ace9fd_e1e5_4ada_acb4_1afaf57d1afc
name: GALNT7
boundary condition: true
initial amount: NaN
is: Q86SF2
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:51809
type: Species

metaR r1630
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM dutp c
has only substance units: false
boundary condition: false
is: C00460
name: dUTP
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
constant: false
initial concentration: 1.0
is: CHEBI:17625

metaR C4OHc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxybytyryl carnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_45c776b8_c1c3_498a_bf59_8ea7249493ca
constant: false
boundary condition: true
name: SLC46A1
is encoded by: hsa:113235
is: SBO:0000252
is: Q96NT5
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaR C4CRNCPT2
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_8787f6eb_bb7a_48e5_9d0e_76f997ffb867
has part: A7E2E0
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: PIK3CD:PIK3R3
is encoded by: hsa:5293
has part: Q92569
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:8503
boundary condition: true

metaM ser L m
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: L-serine
constant: false
is: SBO:0000247
is: CHEBI:17115
is: HMDB00187
has only substance units: false

metaR EX estrones LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Estrone 3-sulfate exchange
type: Reaction

metaR RE2625C
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110059#
name: RE2625
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction
product: MODEL1310110059#
is: SBO:0000176

metaM mpdol L c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:18396

metaR URIDK2m
is: SBO:0000176
kinetic law: MODEL1310110059#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
type: Reaction
product: MODEL1310110059#
name: uridylate kinase (dUMP), mitochondrial
reversible: true
reactant: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_d1132fb5_07c3_42bf_8ddb_2d39c7c313ca
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:79814
is: SBO:0000252
initial concentration: NaN
name: AGMAT
is: Q9BSE5

metaR NACHEX11ly
modifier: MODEL1310110059#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110059#

metaM crvnc c
type: Species
notes: FORMULA: C22H31O2 CHARGE: -1
is: HMDB02183
is: CHEBI:36005
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: cervonic acid, C22:6 n-3
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_ab363f72_604e_4b18_a278_242c04b59e8b
constant: false
is encoded by: hsa:93183
has part: Q8TBF5
type: Species
is: SBO:0000297
has part: Q9H3S5
name: PIGX:PIGM
initial amount: NaN
is encoded by: hsa:54965
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM na1 e
has only substance units: false
boundary condition: false
is: C01330
is: HMDB00588
constant: false
notes: FORMULA: Na CHARGE: 1
initial concentration: 1.0
type: Species
name: Sodium
is: CHEBI:4541
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_2ea25800_52af_4127_a00f_9ed4d578882f
is: SBO:0000252
name: SLC25A2
initial amount: NaN
is encoded by: hsa:83884
constant: false
initial concentration: NaN
is: Q9BXI2
type: Species
has only substance units: false
boundary condition: true

metaM sebcoa x
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
name: sebacoylcoa
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_801a66a6_82c2_4b64_9b77_545177810bfc
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: _AI971023_1_c
has only substance units: false
is encoded by: hsa:AI971023
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_ebb818cc_18d3_4a34_a28d_33a61fe6e4af
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: PAPSS2
is encoded by: hsa:9060
is: O95340
initial amount: NaN
type: Species

metaR GALASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
reactant: MODEL1310110059#
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
modifier: MODEL1310110059#
reversible: false

metaM c51crn c
constant: false
has only substance units: false
is: SBO:0000247
name: tiglyl carnitine
is: HMDB02366
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H21NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110059#_8a97af42_430d_43ea_9d85_798b365eaabd
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AI285872
boundary condition: true
is: SBO:0000252
constant: false
name: _AI285872_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_81464681_9b56_405a_b54a_3f1792dcd0f1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:492
is: SBO:0000252
name: ATP2B3
boundary condition: true
type: Species
is: Q16720
constant: false
initial amount: NaN

metaR ORPT
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110059#
name: orotate phosphoribosyltransferase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.10
reactant: MODEL1310110059#

metaR RTOTAL2FATPc
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaM glx m
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00119
boundary condition: false
is: SBO:0000247
name: glyoxylate
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN
constant: false

metaM tdcrn c
is: HMDB05066
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C21H41NO4 CHARGE: 0
name: myristoyl carnitine
is: SBO:0000247
constant: false

metaM cbasp e
initial amount: NaN
is: CHEBI:32814
notes: FORMULA: C5H6N2O5 CHARGE: -2
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: N-Carbamoyl-L-aspartate
is: C00438
is: HMDB00828
has only substance units: false

metaR r2405
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
reversible: false
product: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
type: Reaction

metaR r0245
fast: false
reactant: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
is: SBO:0000176
modifier: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true

metaR CYTDK2m
type: Reaction
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
name: cytidine kinase (ATP), mitochondrial
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

metaR DTTPtn
name: dTTP diffusion in nucleus
is: SBO:0000185
product: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_2182a362_8274_4d99_967a_1f94c8c4993a
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: SLC17A4
initial concentration: NaN
is: Q9Y2C5
is encoded by: hsa:10050
boundary condition: true

metaR TYROXDAc
is version of: http://identifiers.org/ec-code/1.4.3.4
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000269
reversible: false
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_05d2dd77_f065_437c_b1c3_084ea9e54e0a
has only substance units: false
is: SBO:0000252
name: PLCB1
is encoded by: hsa:23236
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_01ba0b2c_c961_44a1_a80b_358df904cc9d
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5313
name: PKLR
is: P30613
initial amount: NaN

metaR CITtam
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000269
kinetic law: MODEL1310110059#
name: citrate transport, mitochondrial
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is: SBO:0000185
reversible: true
reactant: MODEL1310110059#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110059#_4d9b0705_325e_4d69_a12b_8841efbd7583
type: Species
constant: false
initial amount: NaN
is: B4DK61
boundary condition: true
name: ACOX1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaM retn r
is: CHEBI:35291
boundary condition: false
constant: false
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
has only substance units: false
name: all-trans-retinoate
initial amount: NaN
type: Species
is: SBO:0000247

metaR r1635
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
is: SBO:0000185
modifier: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM adrn c
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN
is: SBO:0000247
name: adrenic acid
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:53487

metaR G14T21g
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
type: Reaction
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false

metaR r0242
reversible: true
modifier: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110059#
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.1

metaR FATP2t
modifier: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000185
fast: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110059#
reversible: true
type: Reaction
name: fatty acid electroneutral transport
is described by: ECO:0000269

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR CORE3GTg
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
product: MODEL1310110059#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is described by: ECO:0000000

metaM r1p c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: SBO:0000247
is: C00442
type: Species
constant: false
has only substance units: false
is: HMDB01489
name: alpha-D-Ribose 1-phosphate
is: CHEBI:57720
boundary condition: false

metaR GCC2am
is version of: http://identifiers.org/ec-code/2.1.2.10
name: glycine-cleavage complex (lipoamide), mitochondrial
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true

metaR GLUDym
is version of: http://identifiers.org/ec-code/1.4.1.3
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NADP), mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
fast: false
is: SBO:0000176

metaR GALNTg
name: GalNAc transferase, Golgi apparatus
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
reversible: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110059#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.41

metaR PI4PLC
name: phosphatidylinositol 4-phosphate phospholipase C
fast: false
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_b8bc7e98_b084_422e_a573_28e886459bd9
is: O00483
is encoded by: hsa:4697
type: Species
name: NDUFA4
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaM ivcoa c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Isovaleryl-CoA
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB01113

metaM CE2434 m
constant: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial concentration: 1.0
is: CHEBI:57795
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM crm hs c
initial concentration: 1.0
is: CHEBI:52639
type: Species
initial amount: NaN
constant: false
name: N-acylsphingosine
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
is: SBO:0000247

metaR FAOXC11
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110059#
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
is: SBO:0000176
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110059#

metaR G14T2g
reversible: false
modifier: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR MI4PP
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000269
type: Reaction
name: myo-inositol 4-phosphatase
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
modifier: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/3.1.3.25
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_ac2328e8_48be_4b49_a678_eba351178b19
constant: false
initial concentration: NaN
is encoded by: hsa:4728
is: O00217
name: NDUFS8
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110059#_fde679bd_c577_47f7_bc01_ea6f5967e75f
name: RRM2B
is: Q7LG56
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:50484
boundary condition: true

metaM CE5132 c
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57923
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
initial concentration: 1.0
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132

metaM crn r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false
type: Species
name: (R)-carnitine
is: HMDB00062
is: CHEBI:16347
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_36c6fb75_b9f7_4a7c_af1b_1c4ed1cee8fd
is: Q7Z3X3
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:2799
name: GNS
is: SBO:0000252
has only substance units: false
constant: false

metaR r1634
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
reversible: true
fast: false
product: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM cbasp c
is: CHEBI:32814
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: SBO:0000247
type: Species
is: C00438
has only substance units: false
is: HMDB00828
name: N-Carbamoyl-L-aspartate
constant: false

metaM ethamp r
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
type: Species
constant: false
name: O-phosphonatoethanaminium(1-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58190
is: HMDB00224
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_042f3ec1_c89d_460e_b195_2f65353fa963
initial amount: NaN
has only substance units: false
is: Q96GD0
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:57026
name: PDXP
initial concentration: NaN

metaM ksii core4 e
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
is: CHEBI:17268
constant: false
boundary condition: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00211

metaM dolmanp L c
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
is: CHEBI:15809
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaR TETDEC2CRNe
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_fc42c9a8_8cce_4297_bf77_240d2994cfd4
initial concentration: NaN
type: Species
is: P00915
is encoded by: hsa:759
name: CA1
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaR FACOAL204
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110059#
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
reversible: true
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
is: SBO:0000176

metaM dcamp c
is: HMDB00536
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57567
is: C03794
constant: false

metaR r1633
is described by: ECO:0000000
reactant: MODEL1310110059#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110059#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110059#

metaR r2408
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_8a958e60_9778_4676_9129_5c9a79a96f26
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:57665
name: RDH14
is: SBO:0000252
is: Q9HBH5
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_fc5cb5f4_5296_4a99_9dc6_d04db663b53a
has only substance units: false
type: Species
constant: false
is encoded by: hsa:6817
initial amount: NaN
name: SULT1A1
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaM adrn e
has only substance units: false
initial amount: NaN
is: CHEBI:53487
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
name: adrenic acid
is: SBO:0000247
is: HMDB02226
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_239c8dab_2b23_4801_a260_812b6383393b
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:1374
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CPT1A
type: Species
is: Q8WZ48

metaM glyc R m
name: D-glycerate
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: HMDB00139
is: CHEBI:16659
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaR HDCAtr
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR FACOAL203
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110059#

metaR r0502
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.7.1.113
type: Reaction
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reversible: true
fast: false
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_566541b4_601d_4db5_9367_754142f5ecdd
is encoded by: hsa:52
is: SBO:0000252
initial concentration: NaN
is: B5MCC7
boundary condition: true
type: Species
name: ACP1
constant: false
has only substance units: false
initial amount: NaN

metaM HC10852 r
initial concentration: 1.0
boundary condition: false
name: palmitoleyl-CoA(4-)
is: CHEBI:61540
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852

metaM pydxn c
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
boundary condition: false
is: HMDB00239
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00314
is: CHEBI:16709
name: Pyridoxine
type: Species
has only substance units: false

metaR GLUTCOAACBP
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaR r1632
kinetic law: MODEL1310110059#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110059#

metaR FAOXC12DCx
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_2c92deb7_81c4_472f_a7e1_b7a0d401e3fc
constant: false
name: PRDX2
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:7001
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_2a66602a_ac13_4cfc_9eb8_aa28a79b9ae1
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:761
type: Species
is: SBO:0000252
boundary condition: true
is: P07451
constant: false
name: CA3

MODEL1310110059#
species: metaM glc D r
species: metaM ksi deg8 l
species: metaM c12dc x
species: metaM apoC m
species: metaM 34hpp e
species: metaM HC01361 e
species: metaM docohexcoa x
species: metaM atp r
species: metaM cs e l
species: metaM ksi pre28 g
species: metaM alpam m
species: metaM fuc1p L c
species: metaM 3tetd7ecoacrn c
species: metaM ade e
species: metaM HC02187 c
species: metaM ptrc e
species: metaM gum e
species: metaM 3ddecdicoa m
has only substance units: false
species: metaM fe3 c
species: metaM cyan c
species: metaM n2m2nm l
species: metaM b2coa m
species: metaM ptdca c
species: metaM hdcecrn c
species: metaM ksi pre17 g
species: metaM tettet6 c
species: metaM hs deg14 l
species: metaM imp c
species: metaM acmanap c
species: metaM ttdca e
species: metaM spmd c
species: metaM dcsptn1coa x
species: metaM q10 c
species: metaM gam c
species: metaM HC00342 m
species: metaM ru5p D r
species: metaM 25aics c
species: metaM cs a deg4 l
species: metaM cholate e
species: metaM pheme m
species: metaM dgchol c
species: metaM ksi pre23 g
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
species: metaM melatn c
species: metaM akg m
species: metaM 2octpencoa m
species: metaM prpncoa m
species: metaM dgtp c
species: metaM odecrn c
species: metaM coa r
species: metaM hdca r
species: metaM oagd3 hs g
species: metaM pi x
species: metaM 5adtststerones e
species: metaM tcynt c
species: metaM ha l
species: metaM ksi pre20 g
species: metaM but e
species: metaM dd2coa c
species: metaM adp x
species: metaM guln r
species: metaM prostge1 e
name: EHHADH:ACAA1:ACOX1
species: metaM cspg b l
species: metaM stcoa m
species: metaM glu5p m
species: metaM 3dsphgn c
species: metaM nadph c
species: metaM leugly c
species: metaM lald D c
species: metaM prostgd2 e
species: metaM doco13ecoa c
species: metaM pheme e
species: metaM sgalside hs c
species: metaM dheas c
species: metaM dolp U r
stoichiometry: 9.0
species: metaM subeac x
species: metaM biliverd c

metaM cdpdag hs c
is: SBO:0000247
name: CDP-diacylglycerol(2-)
is: CHEBI:58332
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_8c89b16a_436d_4ff3_bc19_f4e61de156e3
has only substance units: false
initial amount: NaN
is: Q86VV3
is: SBO:0000252
constant: false
name: ENTPD1
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:953

http://identifiers.org/biomodels.db/MODEL1310110059#_612d8ddb_7bd2_4cfb_9ab7_4b7869943e33
type: Species
is: Q9UNA3
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51146
name: A4GNT

http://identifiers.org/biomodels.db/MODEL1310110059#_833c5379_dfc0_4c5e_9cbc_e0b0d3d5b5e6
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3157
is: Q01581
type: Species
initial amount: NaN
name: HMGCS1
boundary condition: true
is: SBO:0000252
constant: false

metaR CYANt
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110059#
is: SBO:0000185
name: Cyanide transport via diffusion (extracellular to cytosol)
type: Reaction
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM

http://identifiers.org/biomodels.db/MODEL1310110059#_1e0cd822_6b58_4eeb_8179_04b3cc26a903
is encoded by: hsa:5831
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: PYCR1
is: A6NFM2
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_2ddceb94_4766_4c42_8b12_8c771770e8b7
initial concentration: NaN
is encoded by: hsa:123041
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: SLC24A4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_03b927b4_867a_4660_9a4c_dc92c2ea1a5c
constant: false
type: Species
is: O95954
boundary condition: true
is encoded by: hsa:10841
name: FTCD
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r1638
is: SBO:0000185
modifier: MODEL1310110059#
fast: false
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110059#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_f396f66d_93f6_44a6_b182_aace753bcc12
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: SLC23A2
is encoded by: hsa:9962
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM sphs1p r
initial concentration: 1.0
constant: false
name: sphingosine 1-phosphate(1-)
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:60119
is: SBO:0000247
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277

metaM ksi deg1 l
is: SBO:0000247
has only substance units: false
name: keratan sulfate I, degradation product 1
is: CHEBI:18287
initial amount: NaN
boundary condition: false
is: HMDB00174
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C241H383N17O209S12X CHARGE: -13

metaM tmndnccoa x
initial concentration: 1.0
name: timnodonyl coenzyme A
type: Species
has only substance units: false
is: HMDB06514
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false
is: SBO:0000247
boundary condition: false

metaM HC02213 c
initial concentration: 1.0
is: CHEBI:28031
constant: false
has only substance units: false
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: prostaglandin-e3

metaR RE1898C
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110059#
type: Reaction
kinetic law: MODEL1310110059#
product: MODEL1310110059#
is: SBO:0000176
name: RE1898

metaR r1639
type: Reaction
product: MODEL1310110059#
fast: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110059#
is described by: ECO:0000000

metaM 5forthf c
is: SBO:0000247
is: CHEBI:57456
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: C00664
boundary condition: false
name: 5-Formiminotetrahydrofolate
is: HMDB01534
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaM ksii core4 deg2 l
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate II (core 4-linked), degradation product 2
constant: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110059#_c8af3419_46dd_4c67_897d_0562808297ef
is: P48065
constant: false
initial concentration: NaN
initial amount: NaN
name: SLC6A12
is: SBO:0000252
is encoded by: hsa:6539
type: Species
has only substance units: false
boundary condition: true

metaR r0792
product: MODEL1310110059#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110059#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_ec7df6d9_6ca9_4ff4_bcd2_ff5652264f53
is: D6RDW3
initial amount: NaN
is encoded by: hsa:2982
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: GUCY1A3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_c84f0ef6_60cd_44a5_89e9_a1941a2fd76b
is: Q9NS82
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56301
has only substance units: false
type: Species
name: SLC7A10
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_148ab8d8_260a_41cf_a94c_e9431fc5c487
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
name: DBT
initial concentration: NaN
initial amount: NaN
is: P11182
is encoded by: hsa:1629

metaM ksi deg33 l
boundary condition: false
is: HMDB00143
initial concentration: 1.0
constant: false
is: CHEBI:12936
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
type: Species
name: keratan sulfate I, degradation product 33

metaM pmtcoa r
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
is: CHEBI:3454
is: HMDB01338
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: C00154
constant: false
initial amount: NaN

metaR ACOAD10m
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
kinetic law: MODEL1310110059#
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110059#
product: MODEL1310110059#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110059#
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial

metaR r1636
reactant: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_37a5b62d_c160_4928_933d_d6605e67361b
name: TMEM91
is encoded by: hsa:641649
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: C9JZ62

metaR B3GALT3g
kinetic law: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.79
is described by: ECO:0000269
reactant: MODEL1310110059#
name: Beta-1,3-galactosyltransferase 3
is: SBO:0000176
modifier: MODEL1310110059#
reversible: false
fast: false

metaM man l
is: CHEBI:16024
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
initial amount: NaN
name: D-mannose
has only substance units: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR PYDXNK
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.35
modifier: MODEL1310110059#
fast: false
name: pyridoxine kinase

metaM crm hs g
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:52639
name: N-acylsphingosine
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
product: MODEL1310110059#
fast: false
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176

metaR r0791
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110059#
modifier: MODEL1310110059#

metaR RE3006M
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3006
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110059#
reversible: true
product: MODEL1310110059#
kinetic law: MODEL1310110059#
is described by: ECO:0000000

metaR OMHPALTD
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM thcholoylcoa x
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
is: HMDB12456
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: CHEBI:27403

metaM tetdecdicoa x
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
name: 5,8-tetradecadienoylcoa
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: HMDB02288
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_3da1e0e3_0f3a_48d6_b056_6fd958c5383c
constant: false
has only substance units: false
is: Q68CJ7
initial concentration: NaN
name: UROC1
boundary condition: true
is encoded by: hsa:131669
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_c6276c14_776b_4705_b43c_cdcbd8c7d09c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:BF195998
name: _BF195998_1_x
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR DNDPt35m
name: dGDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110059#
product: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
fast: false
reversible: false

metaR r1637
product: MODEL1310110059#
kinetic law: MODEL1310110059#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110059#
fast: false
is: SBO:0000185

metaR THCHOLSTOICtm
fast: false
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110059#
is: SBO:0000185
reversible: true
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
is described by: ECO:0000000

metaM CE5119 m
initial concentration: 1.0
is: CHEBI:57923
has only substance units: false
type: Species
initial amount: NaN
name: trans-3-cis-8-tetradecadienoyl-CoA
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119

metaM octdececrn c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB06351
constant: false
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)

metaR FACOAL200
is described by: ECO:0000269
reactant: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110059#
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110059#
name: fatty-acid--CoA ligase

metaR DM ethamp r
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR DM gncore2 g
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gncore2(g)
type: Reaction

metaM ksi deg8 l
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 8
constant: false
boundary condition: false
type: Species
is: CHEBI:12936
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: HMDB00143
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_51212d10_6ad7_4198_84ff_cceb8cbd0de5
type: Species
is: SBO:0000252
constant: false
is: B7Z6Q4
boundary condition: true
has only substance units: false
name: IMPA1
is encoded by: hsa:3612
initial concentration: NaN
initial amount: NaN

metaM lneldccrn c
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
name: Linoelaidyl carnitine
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: HMDB06461
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_a695f12b_d079_4fdd_9be1_86aa9ebdbd76
is encoded by: hsa:128
type: Species
is: Q6IRT1
is: SBO:0000252
boundary condition: true
name: ADH5
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM gua c
boundary condition: false
constant: false
is: CHEBI:16235
name: Guanine
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
is: SBO:0000247
type: Species
is: C00242

metaR r0962
fast: false
name: Facilitated diffusion
reversible: false
is described by: ECO:0000000
product: MODEL1310110059#
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_d4673606_c6af_4dcb_8bd6_88a52ee184c3
is: P25092
is: SBO:0000252
type: Species
name: GUCY2C
is encoded by: hsa:2984
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM thymd c
is: C00214
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00273
boundary condition: false
name: Thymidine
initial concentration: 1.0
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: CHEBI:17748
constant: false
initial amount: NaN

metaR DRIBt
type: Reaction
reactant: MODEL1310110059#
reversible: true
fast: false
product: MODEL1310110059#
name: deoxyribose transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is: SBO:0000185

metaR RDH2a
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.300
fast: false
reactant: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
name: retinol dehydrogenase (9-cis,NADPH)
is described by: ECO:0000269
product: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.1.1.105

metaM dcmp n
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57566
name: dCMP(2-)
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM CE2839 e
name: maltodecaose
type: Species
boundary condition: false
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
has only substance units: false
is: C01936
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/5041

metaR C12DCTD
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_460fc809_4ac3_46dc_ae5e_8032723fc71a
name: _LOC647190_1_c
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:LOC647190

http://identifiers.org/biomodels.db/MODEL1310110059#_499877bf_e6f1_4e8f_b65e_ec65ed9f8b23
type: Species
initial amount: NaN
boundary condition: true
is: P16233
is: SBO:0000252
constant: false
is encoded by: hsa:5406
has only substance units: false
name: PNLIP
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_ff521826_0a5a_4ba2_9be1_e34a2749f05e
name: _AW299740_1_m
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:AW299740

metaR TMNDNCCRNt
name: transport into the mitochondria (carnitine)
type: Reaction
modifier: MODEL1310110059#
is described by: ECO:0000000
fast: false
product: MODEL1310110059#
is: SBO:0000185
reversible: false
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110059#

metaR TRIODTHYt2
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reactant: MODEL1310110059#
name: T3 transport via facilitated diffusion

metaR r0688
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
reactant: MODEL1310110059#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
type: Reaction
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM ksii core2 pre5 g
constant: false
is: SBO:0000247
is: HMDB00175
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: C00130
is: CHEBI:58053
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 5
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM ksii core4 pre2 g
constant: false
is: HMDB00175
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C00130
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C47H76N4O33X CHARGE: -1
name: keratan sulfate II boisynthesis, precursor 2

metaR RE2625M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110059#
is described by: ECO:0000000
modifier: MODEL1310110059#
product: MODEL1310110059#
type: Reaction
name: RE2625
reversible: true
is: SBO:0000176

metaR PVD3
reversible: true
kinetic law: MODEL1310110059#
fast: false
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
product: MODEL1310110059#
name: Previtamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_7e2d3c9c_1f75_43e5_b1d3_0a719dc8a996
has only substance units: false
type: Species
constant: false
is encoded by: hsa:AI378339
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _AI378339_1_m
initial amount: NaN

metaR XOL27OHtm
kinetic law: MODEL1310110059#
fast: false
type: Reaction
name: 27 hydroxy cholesterol transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110059#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_0325de90_29ed_454a_bfcf_e052f1679962
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:515
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
has part: P18859
is: SBO:0000297
has part: O75947
is encoded by: hsa:518
has part: P24539
is encoded by: hsa:522
is encoded by: hsa:10476
type: Species

metaR MI1P Dtn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110059#
reactant: MODEL1310110059#
name: inositol 1-phosphate nuclear transport (diffusion)
type: Reaction
reversible: true
kinetic law: MODEL1310110059#
is described by: ECO:0000000

metaM gua e
boundary condition: false
name: guanine
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00132
is: SBO:0000247
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
type: Species
constant: false
is: CHEBI:16235

metaM eicostetcoa c
name: eicosatetranoyl coenzyme A
initial amount: NaN
is: C16164
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_9ee49b27_dfec_457b_84b6_2954f4b6b2df
type: Species
is: P15121
initial concentration: NaN
is encoded by: hsa:231
is: SBO:0000252
name: AKR1B1
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaR DMGDHm
name: dimethylglycine dehydrogenase, mitochondrial
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.5.99.2
notes: GENE_ASSOCIATION: (29958.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10767172,PMID:1123190 NOTES:MM
product: MODEL1310110059#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110059#
is described by: ECO:0000269
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#

metaM crn x
is: CHEBI:16347
name: L-Carnitine
is: C00318
has only substance units: false
constant: false
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110059#_80b00cb4_322a_4063_8e6f_e55f4ccde8c7
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P07864
is encoded by: hsa:3948
initial concentration: NaN
name: LDHC
boundary condition: true
type: Species
constant: false

metaR SERGLYexR
product: MODEL1310110059#
is: SBO:0000185
name: L-Serine/Glycine reversible exchange
modifier: MODEL1310110059#
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR r0960
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
reactant: MODEL1310110059#
reversible: true
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:

metaR GASNASE2ly
name: glycosylasparaginase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.26
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
product: MODEL1310110059#
reversible: false
is: SBO:0000176
reactant: MODEL1310110059#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM dag hs n
initial amount: NaN
name: diglyceride
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18035
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055

metaR DMHPTCRNCPT2
name: 2,6 dimethylheptanoly CoA carnitine transferase
type: Reaction
kinetic law: MODEL1310110059#
is described by: ECO:0000000
fast: false
product: MODEL1310110059#
is: SBO:0000176
reversible: true
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ

http://identifiers.org/biomodels.db/MODEL1310110059#_2f3c3ded_9dff_484e_ba3c_7a4b1d38070a
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: CKMT1B
initial concentration: NaN
is encoded by: hsa:1159
constant: false
type: Species
is: P12532
has only substance units: false

metaR S6T15g
fast: false
product: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.17
kinetic law: MODEL1310110059#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110059#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110059#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_018bcf74_ae98_4b88_8cf4_4d21d46efa41
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6513
type: Species
constant: false
initial concentration: NaN
name: SLC2A1
is: P11166

metaM 3hddcoa m
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: HMDB11123
has only substance units: false
is: C05279
name: (S)-3-Hydroxydodecanoyl-CoA

metaM CE2421 m
is: HMDB02329
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:30623
name: (3S)-3-hydroxylinoleoyl-CoA
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_34039c5e_0118_4729_a69d_74389d4cd3d6
name: ALG2
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:85365
type: Species
constant: false
is: Q9H553
initial concentration: NaN
is: SBO:0000252

metaR AG13T10g
reversible: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110059#
product: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110059#
is described by: ECO:0000000

metaM tridcoa m
has only substance units: false
initial concentration: 1.0
is: HMDB13109
is: SBO:0000247
initial amount: NaN
constant: false
name: tridecanoylcoa
type: Species
boundary condition: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4

metaR AG13T2g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
reactant: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110059#
modifier: MODEL1310110059#
kinetic law: MODEL1310110059#

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM pchol hs r
constant: false
has only substance units: false
is: SBO:0000247
type: Species
name: Phosphatidylcholine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

metaM HC02213 e
name: prostaglandin-e3
boundary condition: false
constant: false
is: CHEBI:28031
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: SBO:0000247

metaM dhcholoylcoa x
is: SBO:0000247
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: CHEBI:27393
is: HMDB06895
initial concentration: 1.0
type: Species

metaM HC01434 x
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:58931
constant: false
name: oxalatosuccinate(3-)
initial amount: NaN
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110059#_2b8c61b9_e0da_4579_b410_b29f738dc17c
boundary condition: true
constant: false
name: MAN2B1
type: Species
has only substance units: false
is: O00754
initial concentration: NaN
is encoded by: hsa:4125
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_8efcca46_ab7e_47cc_9ed1_d53432565fca
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:277
is: P04745
initial concentration: NaN
initial amount: NaN
name: AMY1B
boundary condition: true

metaR ALASERNaEx
reactant: MODEL1310110059#
fast: false
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
is: SBO:0000185
is described by: ECO:0000269
reversible: false
type: Reaction
product: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110059#

metaM ocde9ecoa x
name: 9-octadecenoylcoa
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
is: http://identifiers.org/pubchem.compound/5280355
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_7f160ab3_d3e2_4b34_a090_f8972fa4e7eb
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:50
initial amount: NaN
name: ACO2
is: Q99798
has only substance units: false

metaR NDPK2n
modifier: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000269
kinetic law: MODEL1310110059#
fast: false
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is: SBO:0000176
product: MODEL1310110059#
reactant: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR PI45P3K
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
kinetic law: MODEL1310110059#
reversible: false
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110059#_31539202_402c_4cc3_91ff_3b641572471a
is encoded by: hsa:38
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P24752
name: ACAT1
initial amount: NaN
boundary condition: true

metaR SPHMYLNtg
name: sphingomyelin intracellular transport
product: MODEL1310110059#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110059#
type: Reaction
fast: false

metaM din e
has only substance units: false
is: CHEBI:28997
boundary condition: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: C05512
name: Deoxyinosine
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: HMDB00071

http://identifiers.org/biomodels.db/MODEL1310110059#_49988071_740a_4f44_9fdc_b71a0c9b565d
is: SBO:0000252
has only substance units: false
type: Species
name: PPA2
initial amount: NaN
is encoded by: hsa:27068
constant: false
initial concentration: NaN
boundary condition: true

metaR EX tetdec2crn
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaM man c
is: C00159
is: CHEBI:16024
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: D-Mannose
initial concentration: 1.0
boundary condition: false
type: Species

metaR PRGSTRNt
product: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: Progesterone transport

metaR r2090
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110059#
fast: false
kinetic law: MODEL1310110059#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110059#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110059#

metaR r0797
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
kinetic law: MODEL1310110059#
fast: false
product: MODEL1310110059#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
name: glycine N-choloyltransferase EC:2.3.1.65
reactant: MODEL1310110059#
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_ef5f7900_fe4a_428d_980a_b9b435b0736e
constant: false
name: TK1
is encoded by: hsa:7083
is: P04183
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaM octdececrn m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
has only substance units: false
is: SBO:0000247
is: HMDB06351
type: Species
initial amount: NaN
constant: false

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaM crtsl r
type: Species
is: HMDB00063
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
initial concentration: 1.0
name: cortisol
is: SBO:0000247
initial amount: NaN
is: CHEBI:17650

metaM damp c
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: CHEBI:58245
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: dAMP(2-)
type: Species
is: HMDB00905

metaM ksii core4 pre10 g
constant: false
boundary condition: false
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 10
is: SBO:0000247
type: Species
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110059#_cf2709c4_14da_4dea_b0e8_8c5089e13603
type: Species
is encoded by: hsa:3707
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P27987
constant: false
name: ITPKB
boundary condition: true
is: SBO:0000252

metaM ksii core2 deg3 l
is: HMDB00143
constant: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 3
has only substance units: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
boundary condition: false
initial amount: NaN
is: CHEBI:12936
type: Species

metaR r2092
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110059#
type: Reaction
reactant: MODEL1310110059#
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR MAN6PI
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/5.3.1.8
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
name: mannose-6-phosphate isomerase
product: MODEL1310110059#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110059#_de124717_7d5b_4013_b83f_035879324c43
is: Q92523
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: CPT1B
is encoded by: hsa:1375
type: Species

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR ITCOALm
type: Reaction
modifier: MODEL1310110059#
reversible: true
reactant: MODEL1310110059#
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110059#_d504dd24_eb6a_48da_9cbc_8127cbc36b91
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:1718
constant: false
is: Q15392
name: DHCR24
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_fee089f5_004b_4fef_97b8_47722339d05e
is: SBO:0000252
initial concentration: NaN
is: O14732
constant: false
boundary condition: true
has only substance units: false
type: Species
name: IMPA2
is encoded by: hsa:3613
initial amount: NaN

metaR FBP
reactant: MODEL1310110059#
type: Reaction
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
product: MODEL1310110059#
name: fructose-bisphosphatase
reversible: false
modifier: MODEL1310110059#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.11
is described by: ECO:0000000
kinetic law: MODEL1310110059#

metaM tsul c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
is: CHEBI:16094
is: HMDB00257
initial amount: NaN
boundary condition: false
name: thiosulfate(2-)
has only substance units: false
constant: false

metaR COUCOAFm
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
name: p-coumaroyl-CoA formation
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: false

metaM cortsn r
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
initial amount: NaN
is: HMDB02802
has only substance units: false
type: Species
name: cortisone
boundary condition: false
is: CHEBI:16962
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM c6dc x
name: adipoyl carnitine
is: SBO:0000247
notes: FORMULA: C13H22NO6 CHARGE: -1
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB04047
initial amount: NaN
is: C14143
has only substance units: false
constant: false

metaM retinal cis 13 r
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: SBO:0000247
is: HMDB06220
boundary condition: false
is: CHEBI:45487
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: 13-cis-retinal

http://identifiers.org/biomodels.db/MODEL1310110059#_164c2312_c4b9_493b_87f6_fdd47020a035
is: Q9H008
is encoded by: hsa:64077
boundary condition: true
initial amount: NaN
name: LHPP
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR r2091
type: Reaction
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110059#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
modifier: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_434462e0_05db_4dae_a2a8_5a3eefda5ca3
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:956
initial amount: NaN
is: O75355
type: Species
boundary condition: true
name: ENTPD3

metaM pchol hs m
boundary condition: false
name: Phosphatidylcholine
initial concentration: 1.0
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
has only substance units: false
is: CHEBI:16110
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

metaM prostge2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
name: prostaglandin E2(1-)
is: HMDB01220
initial concentration: 1.0
is: CHEBI:606564
has only substance units: false
constant: false

metaM din c
is: C05512
initial amount: NaN
name: Deoxyinosine
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:28997
is: HMDB00071
has only substance units: false
constant: false
is: SBO:0000247

metaM dag hs c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: CHEBI:18035
has only substance units: false
initial amount: NaN
name: diglyceride
constant: false
type: Species

metaM tmndnccoa m
boundary condition: false
type: Species
is: SBO:0000247
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB06514
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_693ce7f9_065d_4d5f_9286_35958de23613
boundary condition: true
is encoded by: hsa:AI024818
initial amount: NaN
is: SBO:0000252
type: Species
name: _AI024818_1_c
has only substance units: false
initial concentration: NaN
constant: false

metaR r2093
modifier: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_a2b37279_e847_4590_8834_dd903312d01e
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4695
name: NDUFA2
constant: false
is: O43678
type: Species
boundary condition: true

metaM man e
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: D-Mannose
is: C00159
constant: false
is: CHEBI:16024

metaR RE3627M
is described by: ECO:0000000
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110059#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3627
modifier: MODEL1310110059#
product: MODEL1310110059#

http://identifiers.org/biomodels.db/MODEL1310110059#_a80bf31e_ab79_44cb_a329_d2b61c01bb32
initial concentration: NaN
name: B3GNTL1
type: Species
is: Q67FW5
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:146712
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110059#_fbfc0ecf_f114_4fcf_b033_c9c7ff65a418
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:522
type: Species
name: ATP5J
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_cbc8c5a9_a08b_4beb_9b9e_3e2c43fcf190
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:6487
constant: false
name: ST3GAL3
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110059#_3ed2edb0_5ee3_4284_918e_58a39c630c54
name: SLC38A5
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:92745
initial concentration: NaN
is: Q8WUX1
is: SBO:0000252
initial amount: NaN

metaM Lkynr c
is: HMDB00684
boundary condition: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16946
name: L-kynurenine

metaM ksii core2 pre4 g
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 4
is: HMDB00175
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C53H86N4O38X CHARGE: -1
has only substance units: false
constant: false
is: CHEBI:58053
initial amount: NaN
is: C00130

metaM nrpphr e
name: Norepinephrine
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
is: CHEBI:33569
boundary condition: false
constant: false
is: HMDB00216
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM ksi deg15 l
type: Species
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
name: keratan sulfate I, degradation product 15
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:12936

metaR r2094
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110059#
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR ASNtN1
is: SBO:0000185
fast: false
reversible: true
name: Asparagine transport (Na, H coupled)
reactant: MODEL1310110059#
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110059#
kinetic law: MODEL1310110059#

metaM eicostetcoa m
has only substance units: false
boundary condition: false
constant: false
name: eicosatetranoyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: C16164
initial amount: NaN
type: Species
is: SBO:0000247

metaR EICOSTETCPT1
product: MODEL1310110059#
name: carnitine O-palmitoyltransferase
reversible: false
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110059#
type: Reaction
fast: false
reactant: MODEL1310110059#

metaR DURIt
type: Reaction
fast: false
name: deoxyuridine transport via diffusion
product: MODEL1310110059#
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
reversible: true

metaM pro D e
is: SBO:0000247
is: HMDB03411
initial concentration: 1.0
boundary condition: false
name: D-proline
is: CHEBI:16313
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR INSK
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110059#
name: insosine kinase
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: false

metaM trp L e
is: HMDB00929
constant: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: L-tryptophan
is: CHEBI:16828
has only substance units: false

metaR r0360
kinetic law: MODEL1310110059#
reversible: false
type: Reaction
modifier: MODEL1310110059#
is: SBO:0000176
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110059#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
product: MODEL1310110059#
is version of: http://identifiers.org/ec-code/6.2.1.16
fast: false

metaR S6TASE12ly
reversible: true
reactant: MODEL1310110059#
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110059#
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110059#
type: Reaction

metaM 4nph c
name: 4-nitrophenolate
is: CHEBI:57917
constant: false
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: HMDB01232
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
initial amount: NaN

metaM prostge2 e
boundary condition: false
initial concentration: 1.0
name: prostaglandin E2(1-)
type: Species
is: CHEBI:606564
is: HMDB01220
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN

metaM leuktrE4 c
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: SBO:0000247
name: leukotriene E4(1-)
is: CHEBI:57462
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02200
boundary condition: false
type: Species

metaR r2095
kinetic law: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110059#
reactant: MODEL1310110059#
reversible: true

metaM man g
name: D-mannose
initial concentration: 1.0
initial amount: NaN
is: HMDB00169
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
is: CHEBI:16024
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_72afd1fc_852a_4296_ab43_a4d6c254fe0e
type: Species
name: AGXT2
is encoded by: hsa:64902
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9BYV1
boundary condition: true
is: SBO:0000252

metaR NADtx
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
type: Reaction
name: transport of NAD into peroxisome
fast: false
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110059#

metaR AMANK
name: N-acetyl-D-mannosamine kinase
is version of: http://identifiers.org/ec-code/5.1.3.14
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.59
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
type: Reaction
product: MODEL1310110059#
kinetic law: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
is described by: ECO:0000269
modifier: MODEL1310110059#

metaR EICOSTETCPT2
reversible: false
is described by: ECO:0000000
name: carnitine transferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110059#
modifier: MODEL1310110059#
fast: false
reactant: MODEL1310110059#
product: MODEL1310110059#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110059#_673c3697_7c61_4ccf_bf16_cc24d7c0a08f
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ACAA1
has only substance units: false
is: Q96CA6
type: Species
boundary condition: true
constant: false
is encoded by: hsa:30

metaM dag hs e
name: diglyceride
is: SBO:0000247
is: CHEBI:18035
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

metaM datp n
is: HMDB01532
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
initial amount: NaN
name: dATP
has only substance units: false
type: Species
constant: false
is: C00131
boundary condition: false
is: CHEBI:61404

metaM na1 x
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
is: HMDB00588
is: CHEBI:29101
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: sodium(1+)
initial amount: NaN

metaM HC01434 m
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
is: CHEBI:58931
boundary condition: false
initial concentration: 1.0
name: oxalatosuccinate(3-)
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR AGDC
notes: GENE_ASSOCIATION: (51005.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.1.25 Confidence Level: 2 AUTHORS: NOTES:acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase
reversible: false
modifier: MODEL1310110059#
name: N-acetylglucosamine-6-phosphate deacetylase
is version of: http://identifiers.org/ec-code/3.5.1.25
fast: false
kinetic law: MODEL1310110059#
is described by: ECO:0000254
is: SBO:0000176
reactant: MODEL1310110059#
type: Reaction
product: MODEL1310110059#

metaM estradiol r
has only substance units: false
initial amount: NaN
is: CHEBI:16469
constant: false
is: HMDB00151
name: estradiol
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110059#_2d1ec914_0d3f_4f4c_a4c3_cf1ecc7b9d23
is encoded by: hsa:4832
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NME3
is: Q13232
has only substance units: false

metaR LINKDEG1ly
is: SBO:0000176
reactant: MODEL1310110059#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110059#
is described by: ECO:0000000
fast: false
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110059#

metaR r0680
type: Reaction
product: MODEL1310110059#
is: SBO:0000176
kinetic law: MODEL1310110059#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
modifier: MODEL1310110059#
is version of: http://identifiers.org/ec-code/2.3.1.137
fast: false
reversible: true
reactant: MODEL1310110059#

metaM nrpphr c
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00216
is: CHEBI:33569
type: Species
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
initial amount: NaN

metaR FAOXC140
product: MODEL1310110059#
modifier: MODEL1310110059#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
type: Reaction
name: Beta oxidation of long chain fatty acid
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110059#
is: SBO:0000176
reactant: MODEL1310110059#

metaM dolmanp L r
constant: false
is: SBO:0000247
has only substance units: false
name: Dolichyl phosphate D-mannose, human liver homolog
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
type: Species
is: CHEBI:15809
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110059#_b735d616_5d47_4e47_b4dc_d22c8a9006d9
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q8N3E9
is encoded by: hsa:113026
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: PLCD3

metaR KSII CORE2tly
reactant: MODEL1310110059#
fast: false
name: keratan sulfate II (core 2) transport, extracellular to lysosome
product: MODEL1310110059#
is: SBO:0000185
kinetic law: MODEL1310110059#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false

metaM hs deg14 l
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16126
boundary condition: false
type: Species
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
name: heparan sulfate, degradation product 14
constant: false
initial amount: NaN

metaM hs deg25 l
type: Species
initial amount: NaN
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: CHEBI:16126
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C23H37O21 CHARGE: -1
has only substance units: false

metaM ksi pre16 g
is: HMDB00175
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 16
is: SBO:0000247
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110059#_7d92ddf9_e1d4_4403_b204_53255035fadd
is encoded by: hsa:23556
initial concentration: NaN
name: PIGN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is: O95427
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_c297b5a8_c79a_43ea_ab15_e09c2d48767c
name: SLC12A4
is: F5H066
has only substance units: false
is encoded by: hsa:6560
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM retinol 9 cis c
is: SBO:0000247
initial amount: NaN
name: 9-cis-retinol
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial concentration: 1.0
is: CHEBI:17336
is: HMDB06217
constant: false

metaR r2096
is: SBO:0000185
product: MODEL1310110059#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110059#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110059#
reversible: true
modifier: MODEL1310110059#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110059#_88fa2cfd_dbfe_4414_acc6_7a793c372d04
initial amount: NaN
is encoded by: hsa:6611
is: SBO:0000252
type: Species
name: SMS
is: P52788
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110059#_34b7ef20_85b1_4e64_a768_2268ddcb686c
initial amount: NaN
initial concentration: NaN
name: FH
constant: false
is encoded by: hsa:2271
is: P07954
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaM trp L c
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: HMDB00929
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: L-tryptophan
has only substance units: false
initial amount: NaN
is: CHEBI:16828

metaM crm hs r
name: N-acylsphingosine
is: CHEBI:52639
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaR GLCNACT L
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
fast: false
type: Reaction
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
kinetic law: MODEL1310110059#
reactant: MODEL1310110059#
product: MODEL1310110059#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110059#_a656272a_ebfe_4354_ba6b_44931e367360
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has part: Q07326
has only substance units: false
boundary condition: true
name: PIGF:PIGO
type: Species
constant: false
has part: Q8TEQ8
is encoded by: hsa:5281
is encoded by: hsa:84720

metaM pro D c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: D-proline
is: HMDB03411
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: CHEBI:16313
type: Species
constant: false

metaR LPSe
modifier: MODEL1310110059#
name: lipase
notes: GENE_ASSOCIATION: (3990.1) or (9388.1) or (5407.1) or (8513.1) or (5408.1) or (5406.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:10318835,PMID:1379598,PMID:1783385,PMID:2753032,PMID:3304425 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
product: MODEL1310110059#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.3
is: SBO:0000176

metaR r0796
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110059#
kinetic law: MODEL1310110059#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110059#
product: MODEL1310110059#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
fast: false
is: SBO:0000176

metaR DCSPTN1COAtx
kinetic law: MODEL1310110059#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reversible: true
product: MODEL1310110059#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110059#