metaM 5mthf c
is: HMDB01396
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:3729
name: 5-Methyltetrahydrofolate
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_0dce2c99_9614_4101_8746_a7bc157a8b41
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:8833
is: SBO:0000252
is: P49915
initial concentration: NaN
boundary condition: true
name: GMPS

metaR AHCYStd
kinetic law: MODEL1310110058#
name: diffusion of S-Adenosyl-L-homocysteine
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
reversible: true

metaM ca2 c
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
type: Species
initial amount: NaN
boundary condition: false
name: calcium(2+)
constant: false
initial concentration: 1.0
is: HMDB00464
has only substance units: false
is: CHEBI:29108

metaR CHAT
is version of: http://identifiers.org/ec-code/2.3.1.6
reactant: MODEL1310110058#
is: SBO:0000176
reversible: true
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
kinetic law: MODEL1310110058#
name: Choline O-acetyltransferase

metaM dgchol x
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
is: CHEBI:36252
has only substance units: false
is: HMDB00637
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaM dutp c
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
name: dUTP
has only substance units: false
is: C00460
type: Species
is: SBO:0000247
is: CHEBI:17625
is: HMDB01191

http://identifiers.org/biomodels.db/MODEL1310110058#_c2ac9fbb_7fde_4778_8642_27c0f229ea34
constant: false
is encoded by: hsa:1806
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: DPYD
is: Q12882
initial amount: NaN
type: Species

metaM fru c
is: SBO:0000247
is: C00095
is: HMDB00660
is: CHEBI:15824
name: D-Fructose
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095

http://identifiers.org/biomodels.db/MODEL1310110058#_069da387_c8f0_40ad_91ac_f885dc593a5e
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4548
boundary condition: true
has only substance units: false
is: Q99707
name: MTR
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_b9ee543f_8c2f_44bc_a0df_e25a9b698f38
is: Q9NPC4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: A4GALT
constant: false
is encoded by: hsa:53947
initial amount: NaN
type: Species

metaM HC00460 c
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
name: 2,5-dihydroxybenzoate
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58044
is: SBO:0000247

metaM dad 2 c
name: 2-deoxyadenosine
is: CHEBI:17256
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00101
constant: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
type: Species
is: SBO:0000247
has only substance units: false

metaR PCHOLPm hs
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: false
reactant: MODEL1310110058#
fast: false
name: choline phosphatase
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_71f450d2_a40f_430a_8b0b_28de23080a51
name: GAL3ST1
has only substance units: false
is: Q99999
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:9514

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaR ADSL1
is: SBO:0000176
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.3.2.2
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is described by: ECO:0000269
name: adenylosuccinate lyase
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_6e219720_13bb_4804_abe3_1520d20e0dc6
is: SBO:0000252
initial amount: NaN
name: COX7B2
has only substance units: false
is: Q8TF08
initial concentration: NaN
is encoded by: hsa:170712
type: Species
boundary condition: true
constant: false

metaR AHCYSte
type: Reaction
reactant: MODEL1310110058#
name: Transport of S-adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110058#
is: SBO:0000185
reversible: true
is described by: ECO:0000134
fast: false
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_9c077585_538d_4237_8f04_fe87177646b6
initial concentration: NaN
name: CBS
initial amount: NaN
is: SBO:0000252
is: Q9NTF0
type: Species
is encoded by: hsa:875
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_de2781f1_c99b_4085_8453_ace9106bc928
is: Q9BW60
has only substance units: false
type: Species
is encoded by: hsa:64834
constant: false
initial concentration: NaN
initial amount: NaN
name: ELOVL1
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_f2a62197_3421_481e_94ad_ffbc6fb90719
is: SBO:0000252
name: _AA854479_1_m
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA854479

metaR RE3326M
fast: false
name: RE3326
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
kinetic law: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_15128fce_73f1_42ca_b8a2_cfeb914712e2
is: SBO:0000252
name: FASN
is encoded by: hsa:2194
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: P49327
boundary condition: true
initial amount: NaN

metaM 5mthf e
initial concentration: 1.0
name: 5-Methyltetrahydrofolate
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
type: Species
boundary condition: false
constant: false
is: CHEBI:3729
is: SBO:0000247
is: HMDB01396

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_3070d005_d208_4496_afb1_3c4bc21127a2
is encoded by: hsa:5158
initial amount: NaN
has only substance units: false
is: B7Z9T9
name: PDE6B
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaM 4mptnl m
boundary condition: false
constant: false
type: Species
name: 4-methylpentanal
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17998
has only substance units: false
is: HMDB01318

metaR LNSTLSr
fast: false
is described by: ECO:0000134
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
is version of: http://identifiers.org/ec-code/5.4.99.7
name: lanosterol synthase
reactant: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
reversible: false
type: Reaction

metaM itaccoa m
type: Species
has only substance units: false
initial concentration: 1.0
name: itaconyl-CoA(5-)
initial amount: NaN
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: HMDB03377
constant: false
is: SBO:0000247
is: CHEBI:57381
boundary condition: false

metaM lnlncg c
is: CHEBI:32391
name: gamma-linolenate
is: HMDB03073
boundary condition: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR r1487
name: EC:6.2.1.3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
reversible: true
product: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000

metaM fru e
is: C00095
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: CHEBI:15824
initial amount: NaN
name: D-Fructose
type: Species
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00660

metaR CRVNCtr
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
reversible: true
type: Reaction

metaM 2hexdtricoa m
is: HMDB02288
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
name: 2,7,10-hexadecatrienoylcoa
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_7f9b01dd_af59_45ad_930b_73ce5bde571a
initial concentration: NaN
is encoded by: hsa:108
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q71UM8
has only substance units: false
type: Species
constant: false
name: ADCY2

metaR HEXCt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion

metaR FAOXC101C8m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_4147ef26_abf4_4e36_b785_b65ee5cfcff2
initial amount: NaN
initial concentration: NaN
name: RRM2
boundary condition: true
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6241
is: P31350

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR LCTStg
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
name: lactose transport from Golgi to extracellular (via vesicle)
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
reversible: false

metaR r2090
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
modifier: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_6a035068_edca_4491_8095_02abd00bb2cc
is: Q9UHV8
name: LGALS13
initial concentration: NaN
is encoded by: hsa:29124
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaM 13 cis oretn n
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H27O3 CHARGE: -1
is: SBO:0000247
is: CHEBI:53486
boundary condition: false
constant: false
is: HMDB02925
initial amount: NaN
type: Species
name: 13-cis-oxo-retinoic acid

http://identifiers.org/biomodels.db/MODEL1310110058#_b7443903_57c2_4b4c_bfde_d2cd9afdd657
boundary condition: true
is: P00390
is: SBO:0000252
has only substance units: false
type: Species
name: GSR
is encoded by: hsa:2936
initial concentration: NaN
initial amount: NaN
constant: false

metaR r2091
product: MODEL1310110058#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110058#

metaR LALDO
reactant: MODEL1310110058#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110058#

metaM galside hs g
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:12947
type: Species
has only substance units: false
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

http://identifiers.org/biomodels.db/MODEL1310110058#_4ec53ab3_b50d_4417_bd99_b43e60fd0352
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: Q8TB61
type: Species
name: SLC35B2
has only substance units: false
is encoded by: hsa:347734

http://identifiers.org/biomodels.db/MODEL1310110058#_81dd3fff_d36f_4735_bd93_1847d2aab1e8
type: Species
boundary condition: true
name: SLC4A5
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:57835
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_8235ea5f_beee_4ac9_a0b0_b2e619d23184
name: ALDOC
boundary condition: true
initial concentration: NaN
is encoded by: hsa:230
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P09972

metaM 10fthf7glu e
constant: false
is: CHEBI:57454
type: Species
name: 10-formyltetrahydrofolate-[Glu](7)
is: SBO:0000247
initial concentration: 1.0
is: HMDB00972
notes: FORMULA: C50H57N13O25 CHARGE: -8
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_2cc38941_827a_4925_bf50_f1aa04c3d234
is: SBO:0000252
name: _AI620219_1_m
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:AI620219
boundary condition: true
type: Species

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM dc2coa m
boundary condition: false
constant: false
has only substance units: false
type: Species
name: trans-Dec-2-enoyl-CoA
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
is: CHEBI:61406
initial amount: NaN
is: SBO:0000247

metaM lnlncg e
initial concentration: 1.0
constant: false
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB03073
type: Species
is: CHEBI:32391

metaM galside hs l
constant: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM 3mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: HMDB01493
initial amount: NaN
is: SBO:0000247
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57344

http://identifiers.org/biomodels.db/MODEL1310110058#_b93001d8_852e_4baa_8c26_38a9b82bca7f
is: Q9Y5P4
name: COL4A3BP
boundary condition: true
has only substance units: false
is encoded by: hsa:10087
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r0474
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaR r1749
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#

metaM glygn2 e
initial concentration: 1.0
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})
has only substance units: false
constant: false
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134
initial amount: NaN
is: CHEBI:4167
type: Species
is: HMDB00122
boundary condition: false
is: SBO:0000247

metaR NDP7g
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
name: nucleoside-diphosphatase (UDP), Golgi apparatus
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
fast: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR MMCDm
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
reversible: false
reactant: MODEL1310110058#
name: Methylmalonyl-CoA decarboxylase, mitochondrial
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/4.1.1.9

http://identifiers.org/biomodels.db/MODEL1310110058#_dd597f85_d979_4ad0_aaa0_c01af437447d
initial concentration: NaN
initial amount: NaN
type: Species
name: LEFTY1
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:10637
is: O75610
constant: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM 13dampp c
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: trimethylenediaminium
is: SBO:0000247
is: HMDB00002
is: CHEBI:57484
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
type: Species
initial amount: NaN

metaM HC02205 c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: CHEBI:28099
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: prostaglandin-b2

http://identifiers.org/biomodels.db/MODEL1310110058#_b9f79089_dfbb_47c5_82ea_9bb775cd5e69
has only substance units: false
constant: false
name: SLC26A8
is: SBO:0000252
initial concentration: NaN
is: Q96RN1
is encoded by: hsa:116369
initial amount: NaN
type: Species
boundary condition: true

metaR r0475
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110058#
fast: false
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000

metaR HISTAtu
is: SBO:0000185
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110058#
is described by: ECO:0000269
name: Histamine uniport
type: Reaction
fast: false
reactant: MODEL1310110058#
reversible: true

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_5aec9e4d_0cd8_4403_83e0_b95fc7979a6f
is: SBO:0000252
constant: false
is encoded by: hsa:10005
is: O14734
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: ACOT8

http://identifiers.org/biomodels.db/MODEL1310110058#_dddb0ce6_e67f_41ac_a838_fddb62c905db
constant: false
initial concentration: NaN
has only substance units: false
is: Q96QD8
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:54407
initial amount: NaN
name: SLC38A2

http://identifiers.org/biomodels.db/MODEL1310110058#_65068b86_30b3_48d8_a721_64cbfbcf5b7c
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:55753
is: Q9ULD0
name: OGDHL

metaR r1748
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM lys L c
name: L-lysinium(1+)
constant: false
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00182

metaM ca2 e
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN
name: calcium(2+)
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00464
is: CHEBI:29108
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_313bd3ec_fdcb_4f6d_a6ad_074c53323123
is: SBO:0000252
is encoded by: hsa:226
name: ALDOA
initial amount: NaN
type: Species
is: P04075
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_f3612800_867c_4fce_bad9_2ecc4a55113d
is encoded by: hsa:1374
type: Species
constant: false
is: SBO:0000252
is: Q8WZ48
boundary condition: true
initial amount: NaN
name: CPT1A
has only substance units: false
initial concentration: NaN

metaR DHAAt1r
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is described by: ECO:0000269
product: MODEL1310110058#
type: Reaction
name: dehydroascorbate transport (uniport)

http://identifiers.org/biomodels.db/MODEL1310110058#_6707f55c_0131_4a4e_aa1a_e3d533aed04d
is: P49247
type: Species
is encoded by: hsa:22934
has only substance units: false
name: RPIA
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR AG13T2g
product: MODEL1310110058#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reactant: MODEL1310110058#
fast: false
reversible: false

metaR r0472
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_d7c0da0a_c1a1_4d35_be6e_8ee2a4913922
constant: false
type: Species
has only substance units: false
name: ACADS
is: P16219
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:35
is: SBO:0000252

metaR CHOLATEt
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
modifier: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
reversible: true
name: cholate transport via bicarbonate countertransport
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000269

metaR RE3421R
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
name: RE3421
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reversible: true
fast: false
is: SBO:0000176

metaM asp D x
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
initial amount: NaN
is: HMDB06483
is: CHEBI:29990
name: D-aspartate(1-)
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_efe6e4d7_c345_41d4_b8a8_69481ab34c44
initial amount: NaN
constant: false
is: Q7Z4L0
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:341947
name: COX8C

metaR GLUtr
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
reactant: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
type: Reaction
name: intracellular transport

metaM udpacgal l
is: HMDB00304
initial concentration: 1.0
type: Species
is: CHEBI:57847
constant: false
is: SBO:0000247
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_82819801_61cd_4ed8_9f8a_a863d326cd90
initial concentration: NaN
type: Species
constant: false
is: Q6PII5
is encoded by: hsa:84264
name: HAGHL
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_cde5a253_9344_44dc_b3e3_17d43c7a9b07
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:10317
is: SBO:0000252
has only substance units: false
name: B3GALT5
initial concentration: NaN

metaM acetol c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB06961
is: SBO:0000247
type: Species
is: CHEBI:27957
constant: false
initial amount: NaN
name: hydroxyacetone

metaR r0365
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reactant: MODEL1310110058#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

metaR PHEMEt
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
reversible: false
name: heme transport
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_ecec867b_f0f7_4157_b39b_015ba4115ac8
is encoded by: hsa:7263
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q16762
name: TST
type: Species

metaR r2096
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#

metaR XOLTRIOLtm
product: MODEL1310110058#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_e2dcd74e_7fad_464a_b264_f2fd81e0359a
type: Species
is: P24311
initial concentration: NaN
name: COX7B
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:1349

http://identifiers.org/biomodels.db/MODEL1310110058#_d7245099_435b_4bbd_8287_e899c5f1d480
is encoded by: hsa:5294
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PIK3CG
boundary condition: true
type: Species
is: P48736

metaM lys L e
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00182
type: Species
has only substance units: false
is: CHEBI:32551
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)

metaR THRD L
fast: false
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
is described by: ECO:0000269
reactant: MODEL1310110058#
name: L-threonine deaminase
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.3.1.17
product: MODEL1310110058#

metaR DCSPTN1CRNt
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_13e1ead4_1c29_4310_8569_f262dd935fb5
is: SBO:0000297
initial amount: NaN
has part: Q9HCC0
boundary condition: true
has only substance units: false
is encoded by: hsa:64087
initial concentration: NaN
has part: Q96RQ3
is encoded by: hsa:56922
constant: false
type: Species
name: MCCC1:MCCC2

http://identifiers.org/biomodels.db/MODEL1310110058#_675eaa61_0515_422c_b4ac_2b3332b19645
name: _W74642_1_c
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:W74642
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR RETNt
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true
fast: false
name: retinoic acid transport
product: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110058#_59d88383_1664_45ec_8f53_d5057e09598a
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2653
type: Species
boundary condition: true
initial amount: NaN
is: P23434
name: GCSH
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_c93370ee_579b_471f_9418_ce0fb6452e70
name: NDUFA8
initial amount: NaN
is encoded by: hsa:4702
is: SBO:0000252
type: Species
constant: false
is: B1AM93
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_dd74a2cd_be68_431e_ba01_95bc961d62fd
name: _2544_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:2544
constant: false

metaM CE2434 m
constant: false
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial amount: NaN
boundary condition: false
is: CHEBI:57795
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM HC00229 e
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: CHEBI:28189
name: Isomaltose
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_2547682c_054c_4c63_9154_0f5546346f64
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC4A3
is encoded by: hsa:6508
constant: false
initial concentration: NaN
type: Species

metaR r2097
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110058#

metaR CO2ter
reversible: true
product: MODEL1310110058#
name: CO2 endoplasmic reticular transport via diffusion
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_4ac5b0ca_a42b_4f72_b797_e7ccc381282e
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:3795
initial amount: NaN
type: Species
name: KHK
initial concentration: NaN
constant: false
is: P50053

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_c7dcf1ce_f6cc_46b7_91c1_44cc7e26365e
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ATP5G3
type: Species
is encoded by: hsa:518
is: P48201

http://identifiers.org/biomodels.db/MODEL1310110058#_218ae801_60bd_49d1_861c_5b6b3b59af51
initial amount: NaN
type: Species
name: CPT1B
is: SBO:0000252
has only substance units: false
is: B7Z5T8
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1375

metaM lgnccoa c
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
name: lignocericyl coenzyme A
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB06526
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_f0c77eb2_a922_49a9_9172_3beae516393e
is encoded by: hsa:10873
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q6TCH8
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: ME3

metaM 3snpyr m
is: SBO:0000247
boundary condition: false
is: HMDB02332
type: Species
initial concentration: 1.0
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:1665
name: 3-Sulfinopyruvate

metaR r2098
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110058#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_9036c9e4_1561_4c09_aa16_4a0d5433853e
boundary condition: true
type: Species
is: P16260
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8034
has only substance units: false
initial concentration: NaN
name: SLC25A16

metaR EX HC02176 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: laurate exchange
type: Reaction

metaR r0921
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
is described by: ECO:0000000
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Postulated transport reaction
type: Reaction

metaR r1116
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
reversible: true
product: MODEL1310110058#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1

metaR GALt1r
is: SBO:0000185
product: MODEL1310110058#
modifier: MODEL1310110058#
reversible: true
name: galactose transport (uniport)
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000269
kinetic law: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_ee1d3d11_7bfd_47ef_b27a_83bbd4321388
boundary condition: true
has only substance units: false
initial amount: NaN
is: A8K0T6
initial concentration: NaN
is encoded by: hsa:55512
name: SMPD3
constant: false
type: Species
is: SBO:0000252

metaR INSTt2r
fast: false
modifier: MODEL1310110058#
name: inositol transport in via proton symport
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
is described by: ECO:0000269
is: SBO:0000185
reversible: true
reactant: MODEL1310110058#
product: MODEL1310110058#

metaR S6T14g
kinetic law: MODEL1310110058#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110058#

metaR C4STMO2Pr
is: SBO:0000176
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
name: C-4 methyl sterol oxidase
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reversible: false
reactant: MODEL1310110058#
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.170

metaR r0364
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reactant: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction

metaR DCSPTN1t
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000185
product: MODEL1310110058#
name: fatty acid transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_99c0ddd6_6b66_4584_8052_6bb6839c58ff
is: SBO:0000252
boundary condition: true
name: ATP5G1
initial amount: NaN
type: Species
constant: false
is: P05496
has only substance units: false
is encoded by: hsa:516
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_371de567_8bb3_48f3_bb3e_81b89bc340ee
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:5152
is: SBO:0000252
initial concentration: NaN
name: PDE9A
constant: false
has only substance units: false

metaR UMPK
kinetic law: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
name: UMP kinase
product: MODEL1310110058#

metaR r2099
modifier: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_47640369_970f_40a8_a0f2_4d6605aa9f12
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: FADS1
is: O60427
has only substance units: false
constant: false
type: Species
is encoded by: hsa:3992
initial amount: NaN

metaM HC02205 e
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: prostaglandin-b2
initial concentration: 1.0
is: CHEBI:28099
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247

metaR LEUt5m
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
name: leucine mitochondrial transport
type: Reaction
product: MODEL1310110058#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000

metaM ksi pre1 g
is: CHEBI:58053
notes: FORMULA: C79H129N5O57X CHARGE: -1
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 1
is: HMDB00175
type: Species
is: C00130

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_31f199cf_3b5b_49d9_aad7_3b41738813a5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PIK3C2B
is: O00750
constant: false
type: Species
is encoded by: hsa:5287
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_193d519f_08eb_4701_bac4_e9089195978d
is: SBO:0000252
initial concentration: NaN
constant: false
is: P21399
boundary condition: true
has only substance units: false
type: Species
name: ACO1
is encoded by: hsa:48
initial amount: NaN

metaR ADK3m
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reactant: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: adentylate kinase (GTP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10

metaM pchol hs m
constant: false
type: Species
is: CHEBI:16110
has only substance units: false
name: Phosphatidylcholine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
boundary condition: false

metaR TTDCAtr
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110058#
name: tetradecanoate (transport)
reversible: true
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110058#

metaM udpacgal g
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN
constant: false
is: HMDB00304
initial concentration: 1.0
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
boundary condition: false
type: Species

metaM pro L e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
type: Species
constant: false
has only substance units: false
is: HMDB00162
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_8953e5a1_4889_44f9_a823_f92fabd031ea
is: P23378
initial amount: NaN
type: Species
has only substance units: false
name: GLDC
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:2731

metaR DSAT
reversible: false
name: dihydrosphingosine N-acyltransferase
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
fast: false

metaR r2092
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110058#_e237c1c3_af7f_4453_88e4_f971722c995d
type: Species
initial concentration: NaN
is: Q8TF71
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: SLC16A10
is encoded by: hsa:117247

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR 4OHPROIMINOtc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-OH-Proline by the apical IMINO amino acid transporters in kidney and intestine
type: Reaction

metaM lpam m
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: lipoamide
type: Species
initial amount: NaN
is: CHEBI:17460
is: HMDB00962

http://identifiers.org/biomodels.db/MODEL1310110058#_2ed352e1_a3c9_4333_990f_c930de24ed1a
has only substance units: false
type: Species
name: SI
is: P14410
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:6476
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_77dbb3a5_0f53_43d0_8fd0_2fa76c0ab032
is: Q16718
initial concentration: NaN
is encoded by: hsa:4698
boundary condition: true
name: NDUFA5
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_f43b5be7_cf2c_4b3a_a20c_9739f251b96a
is: SBO:0000252
boundary condition: true
type: Species
name: ATP5J
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: P18859
is encoded by: hsa:522

metaR HACD9m
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is described by: ECO:0000134
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
modifier: MODEL1310110058#
fast: false
reversible: true
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR HEXCCOAtx
product: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
name: fatty acid intracellular transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction

metaR r2093
product: MODEL1310110058#
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
is described by: ECO:0000000

metaM galside hs e
is: CHEBI:12947
constant: false
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_25f3f2e7_4d32_466c_8751_4407bc00f32f
is encoded by: hsa:3295
initial amount: NaN
is: E9PB82
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: HSD17B4
initial concentration: NaN

metaR PROSTGE2t
product: MODEL1310110058#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: prostaglandin transport via bicarbonate countertransport
reversible: true

metaR r1117
reactant: MODEL1310110058#
name: Facilitated diffusion
product: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b0545085_7b2b_4c74_8c58_041ef8ca8ffc
initial amount: NaN
is encoded by: hsa:AI348006
type: Species
initial concentration: NaN
name: _AI348006_1_c
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM retinal cis 13 r
is: CHEBI:45487
has only substance units: false
name: 13-cis-retinal
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB06220
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
type: Species
constant: false

metaM 6thf e
constant: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: SBO:0000247
type: Species
name: hexaglutamyl folate (THF)
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/169691

http://identifiers.org/biomodels.db/MODEL1310110058#_d5bd84da_5de3_4fd5_823a_622250526206
is encoded by: hsa:8813
is: SBO:0000297
has only substance units: false
boundary condition: true
name: DPM3:DPM1:DPM2
type: Species
is encoded by: hsa:54344
initial concentration: NaN
has part: O60762
has part: Q86TM7
initial amount: NaN
is encoded by: hsa:8818
has part: O94777
constant: false

metaR S2TASE3ly
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
kinetic law: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
reversible: false
type: Reaction
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.6.13
fast: false
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
product: MODEL1310110058#

metaM ethamp c
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
has only substance units: false
is: CHEBI:58190
constant: false
name: ethamp[c]
type: Species
is: HMDB00224
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_cd991fba_32b0_4b38_b330_e6dcd2176943
name: PCBD1
type: Species
initial concentration: NaN
is: P61457
is encoded by: hsa:5092
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR MI1PP
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
type: Reaction
fast: false
product: MODEL1310110058#
name: myo-inositol 1-phosphatase
modifier: MODEL1310110058#

metaM dad 2 e
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
name: 2-deoxyadenosine
is: SBO:0000247
is: CHEBI:17256
constant: false
is: HMDB00101
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_c915ddd3_1c79_420c_bb71_eb6238cd8fcc
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:92745
initial concentration: NaN
name: SLC38A5
is: Q8WUX1
constant: false
type: Species
boundary condition: true
has only substance units: false

metaR r2094
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110058#

metaM HC01842 c
is: CHEBI:31997
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
name: Phosphodimethylethanolamine
initial concentration: 1.0

metaM pro L c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
initial amount: NaN
name: L-proline
has only substance units: false
type: Species
is: HMDB00162
constant: false

metaR MI145PK
type: Reaction
modifier: MODEL1310110058#
name: inositol-1,4,5-trisphosphate 3-kinase
reversible: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110058#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.127
is: SBO:0000176
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#

metaM 3hbcoa m
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial concentration: 1.0
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: HMDB01166
initial amount: NaN
has only substance units: false
is: CHEBI:57316

metaM tettet6coa c
has only substance units: false
is: HMDB06516
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: C16171
is: http://identifiers.org/pubchem.compound/47205481
name: tetracosatetraenoyl coenzyme A
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

metaR CAATPS
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
fast: false
name: Ca ATPase
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
is version of: http://identifiers.org/ec-code/3.6.3.8
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000269
reversible: false
type: Reaction

metaR HIStN1
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
reversible: true
name: Histidine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_7562b260_79d6_41de_822b_fb723bc75aa9
is: SBO:0000252
is: P21108
has only substance units: false
is encoded by: hsa:221823
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: PRPS1L1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_05baede0_46fc_425a_b601_7862f510d5f5
constant: false
initial concentration: NaN
boundary condition: true
is: Q546Y9
initial amount: NaN
is encoded by: hsa:57379
is: SBO:0000252
name: AICDA
has only substance units: false
type: Species

metaM f6p c
type: Species
is: CHEBI:57579
boundary condition: false
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3385
initial amount: NaN
name: D-Fructose 6-phosphate
is: C00085
is: SBO:0000247
initial concentration: 1.0
is: HMDB00124

http://identifiers.org/biomodels.db/MODEL1310110058#_b358eea9_ea27_4679_8e9d_a455443f5315
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: E9KL44
is encoded by: hsa:3030
type: Species
initial amount: NaN
constant: false
name: HADHA
has only substance units: false

metaM galside hs c
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0

metaR r2095
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110058#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110058#

metaR r0926
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_aa8027ab_d6e2_42f7_a8ee_d825d95fefac
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:6584
constant: false
is: O76082
name: SLC22A5
initial concentration: NaN
boundary condition: true

metaR DHORTS
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is: SBO:0000176
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.1.3.2
name: dihydroorotase
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
reversible: true

metaM udpacgal c
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
has only substance units: false
is: CHEBI:57847
is: SBO:0000247
is: HMDB00304

metaR ALDD2x
type: Reaction
modifier: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reactant: MODEL1310110058#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110058#
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM hmgcoa m
has only substance units: false
is: CHEBI:15467
is: HMDB01375
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_05bb27aa_9227_4b70_ab90_312b27be1bd6
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: B2RDZ2
is encoded by: hsa:55312
initial amount: NaN
name: RFK
initial concentration: NaN
type: Species

metaR FAOXC140
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
name: Beta oxidation of long chain fatty acid

metaR EX 34hpp
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM cholcoads x
has only substance units: false
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
constant: false
is: CHEBI:27505
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB06889
initial amount: NaN

metaR ETHAK
name: Ethanolamine kinase
fast: false
product: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.1.82
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD

metaR DATPtn
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: dATP diffusion in nucleus
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110058#_9222a083_43d9_43e0_a32c_9754b8c57478
constant: false
initial amount: NaN
name: ALG3
type: Species
has only substance units: false
is encoded by: hsa:10195
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR MG3er
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reversible: false
reactant: MODEL1310110058#

metaR M16NTg
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.143
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110058#
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
reversible: false
type: Reaction
reactant: MODEL1310110058#

metaR CDPDAGtm
kinetic law: MODEL1310110058#
name: intracellular transport
type: Reaction
is: SBO:0000185
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR GGH 10FTHF7GLUe
is described by: ECO:0000000
is: SBO:0000176
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
modifier: MODEL1310110058#
type: Reaction
fast: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110058#

metaR THRASNNaEx
kinetic law: MODEL1310110058#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
reversible: false
is: SBO:0000185
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
reactant: MODEL1310110058#

metaM fmn c
constant: false
is: CHEBI:58210
boundary condition: false
is: C00061
type: Species
is: HMDB01520
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: FMN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_0862a470_320c_4eae_91b9_6031e1ddf4ad
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:518
name: ATP5G3

metaR ALDD2y
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
name: aldehyde dehydrogenase (acetaldehyde, NADP)
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176

metaM lys L m
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: L-lysinium(1+)
is: SBO:0000247
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
is: CHEBI:32551
initial concentration: 1.0

metaR BILIRUBt2
is: SBO:0000185
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reactant: MODEL1310110058#
name: bilirubin transport via bicarbonate countertransport
product: MODEL1310110058#
reversible: true

metaM udpgal g
initial amount: NaN
name: UDP-D-galactose(2-)
is: HMDB00302
constant: false
boundary condition: false
is: CHEBI:58439
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC164GC163m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaM mal L m
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
is: CHEBI:15589
type: Species
name: (S)-malate(2-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM fmn e
name: FMN
has only substance units: false
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:58210
boundary condition: false
is: HMDB01520
constant: false
is: C00061

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR r1860
name: Y+LAT2 Utilized transport
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
type: Reaction

metaR r1260
product: MODEL1310110058#
reversible: false
type: Reaction
fast: false
name: EC:6.2.1.3
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176

metaM HC01408 m
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
is: SBO:0000247
name: 3-Oxohexanoyl-CoA
is: CHEBI:27648

metaM CE5788 e
is: HMDB02710
initial concentration: 1.0
type: Species
name: kinetensin 1-7
constant: false
has only substance units: false
is: CHEBI:27485
is: SBO:0000247
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
boundary condition: false
initial amount: NaN

metaM cs e deg4 l
constant: false
boundary condition: false
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
notes: FORMULA: C31H46NO38S4 CHARGE: -5
is: CHEBI:15748
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110058#_f5667cbe_6cd5_4353_9ac3_95be673acd24
is: SBO:0000252
boundary condition: true
name: TDO2
initial concentration: NaN
type: Species
is: P48775
has only substance units: false
initial amount: NaN
is encoded by: hsa:6999
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5a13d2b8_52d5_420f_86f1_3697e15c621b
has only substance units: false
boundary condition: true
is encoded by: hsa:1607
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: Q9Y6T7
name: DGKB

metaR AMY2e
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110058#
name: alpha-amylase, extracellular (glygn2 -> glygn4)
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110058#
is: SBO:0000176
type: Reaction

metaM HC00718 c
initial concentration: 1.0
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: SBO:0000247
constant: false
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57781

metaR RE3074X
modifier: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: true
name: RE3074
is: SBO:0000176
fast: false

metaR FORtr
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
fast: false
reversible: true
kinetic law: MODEL1310110058#
name: FOR transporter, endoplasmic reticulum
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR FAOXC163C164Gm
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR HISSNAT5tc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_49461520_7719_4d42_87e7_2815f4d8f225
initial amount: NaN
is encoded by: hsa:55350
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: VNN3

http://identifiers.org/biomodels.db/MODEL1310110058#_1891eb41_e10b_4e9c_9ede_37da9df3a386
initial concentration: NaN
type: Species
has only substance units: false
name: IMPA2
is encoded by: hsa:3613
constant: false
boundary condition: true
is: O14732
is: SBO:0000252
initial amount: NaN

metaM acgagbside hs g
is: CHEBI:15347
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01659
initial amount: NaN
boundary condition: false
name: alpha GalNAc globoside
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110058#_92e7e0fc_0bc2_4db9_92f4_17b17aa5364a
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFA13
is encoded by: hsa:51079
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9P0J0

metaM 3oddcoa m
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
name: 3-Oxododecanoyl-CoA
constant: false
is: CHEBI:27868
initial amount: NaN
initial concentration: 1.0
is: HMDB03937

metaR 3HCO3 NAt
is described by: ECO:0000134
product: MODEL1310110058#
name: 3HCO3_NAt
type: Reaction
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_cd014402_ac8c_4621_9f22_8ff1b730fc7c
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q02218
name: OGDH
constant: false
is encoded by: hsa:4967
type: Species
initial concentration: NaN
is: SBO:0000252

metaR GGH 7THFe
reactant: MODEL1310110058#
type: Reaction
name: Gamma-glutamyl hydrolase (7THF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110058#

metaM dectricoa m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
name: 2,4,7-decatrienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
constant: false
notes: FORMULA: C31H44N7O17P3S CHARGE: -4

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM udpgal e
has only substance units: false
is: CHEBI:58439
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
is: HMDB00302
constant: false

metaR EX whddca LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: omega hydroxy dodecanoate (n-C12:0) exchange
type: Reaction

metaR r2089
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR RE3050R
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
fast: false
name: RE3050
product: MODEL1310110058#
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_30ca3084_1d67_4e84_8485_44fcd14f4e8c
is encoded by: hsa:29920
name: PYCR2
constant: false
type: Species
is: Q96C36
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_0127579e_be31_4b62_9370_6fa039b8074f
initial amount: NaN
is: P12074
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1337
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: COX6A1

metaR GLXtp
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
fast: false
name: glyoxylate transport, peroxisomal

metaR PTE4x
name: peroxisomal acyl-CoA thioesterase
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
type: Reaction
reversible: false
fast: false
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_ad083438_5e9f_489e_895c_2e77545a2631
is: Q546H9
type: Species
is: SBO:0000252
name: ALDH5A1
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:7915
initial concentration: NaN
boundary condition: true

metaM CE2435 m
is: CHEBI:57795
name: trans,cis-deca-2,4-dienoyl-CoA
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

metaM ksi pre21 g
has only substance units: false
is: HMDB00175
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
initial amount: NaN
boundary condition: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 21
is: SBO:0000247
is: C00130
constant: false
initial concentration: 1.0
type: Species

metaR r2088
fast: false
reversible: true
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110058#_742f1df6_38da_4065_86fe_e8171f01f4e9
name: ALDH1A3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:220
is: P47895

metaR FAOXC204
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM tettet6 e
initial concentration: 1.0
initial amount: NaN
is: HMDB06246
boundary condition: false
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
is: SBO:0000247
has only substance units: false
type: Species
name: tetracosatetraenoic acid n-6
constant: false

metaR CYSTS
name: cystathionine beta-synthase
modifier: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.22
is described by: ECO:0000269
product: MODEL1310110058#

metaM dgchol c
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00637
is: SBO:0000247
constant: false
is: CHEBI:36252
name: glycochenodeoxycholate
has only substance units: false
type: Species

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_fe2d8036_f523_4e33_af33_fff2ec8bbf05
constant: false
is: SBO:0000252
boundary condition: true
name: PDE2A
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: Q8IW54
is encoded by: hsa:5138

metaR C10CRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaM gluala e
is: SBO:0000247
boundary condition: false
name: 5-L-Glutamyl-L-alanine
type: Species
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: HMDB06248
is: http://identifiers.org/pubchem.compound/6503
constant: false
initial amount: NaN
is: C03740
initial concentration: 1.0
has only substance units: false

metaM udpgal c
is: HMDB00302
constant: false
is: CHEBI:58439
type: Species
boundary condition: false
initial amount: NaN
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_9e6a283e_4b59_4ebe_9268_472af34eefd5
constant: false
name: SLCO1C1
is encoded by: hsa:53919
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q5JPA4
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_8729f521_432c_4115_9538_d2a172c4c283
name: ALG8
type: Species
has only substance units: false
is: A6NDW6
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:79053
constant: false
is: SBO:0000252
boundary condition: true

metaM 56dthm c
name: 5,6-dihydrothymine
boundary condition: false
is: CHEBI:27468
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial concentration: 1.0
is: HMDB00079
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247

metaR r0360
is: SBO:0000176
modifier: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_dfc75907_03ba_48fd_bd99_8bf9617814ba
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA614647
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: _AA614647_1_c

http://identifiers.org/biomodels.db/MODEL1310110058#_bb3a627c_4b0d_4e44_b131_239dfee7c09c
is encoded by: hsa:4717
constant: false
initial amount: NaN
is: SBO:0000252
is: O43677
has only substance units: false
name: NDUFC1
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_355598d3_cff6_4407_812b_4869a7865aee
is: P40879
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC26A3
is encoded by: hsa:1811

metaM focytC m
boundary condition: false
initial concentration: 1.0
name: Ferrocytochrome C
type: Species
is: SBO:0000247
is: CHEBI:16928
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_1c3e9f02_8f8b_4d16_95ec_9a9c5315658e
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: O94903
name: PROSC
is: SBO:0000252
is encoded by: hsa:11212

http://identifiers.org/biomodels.db/MODEL1310110058#_c85958d4_34f9_4331_b395_9f672fb81a96
boundary condition: true
constant: false
name: COX7A2
is: SBO:0000252
is encoded by: hsa:1347
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: H0UI06
type: Species

metaR PGCD
type: Reaction
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
name: phosphoglycerate dehydrogenase
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.95
reversible: false
fast: false
modifier: MODEL1310110058#

metaM nicrns c
has only substance units: false
is: HMDB06809
type: Species
name: Nicotinate D-ribonucleoside
initial concentration: 1.0
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:58527

metaM HC10852 r
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
is: CHEBI:61540
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
name: palmitoleyl-CoA(4-)
initial concentration: 1.0
constant: false

metaR D3AIBTm
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
fast: false
product: MODEL1310110058#
is: SBO:0000176
reversible: true
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
type: Reaction

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR DM ethamp r
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR ARAB Lt
product: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
name: L-arabinoase extracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110058#

metaM acgagbside hs c
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:15347
has only substance units: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
constant: false
is: HMDB01659
boundary condition: false
name: alpha GalNAc globoside
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_f1a45e83_027c_4844_9786_e802db23dcbb
is encoded by: hsa:5831
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P32322
boundary condition: true
name: PYCR1
constant: false
type: Species
initial concentration: NaN

metaM dgchol e
has only substance units: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00637
is: SBO:0000247
constant: false
is: CHEBI:36252
type: Species
name: glycochenodeoxycholate

metaR RTOTAL3t
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110058#
type: Reaction
reversible: true
name: RTOTAL3 transport

metaM tettet6 c
constant: false
initial amount: NaN
is: HMDB06246
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
boundary condition: false
has only substance units: false
name: tetracosatetraenoic acid n-6
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM dutp m
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01191
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
is: CHEBI:17625
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_14facbb6_201d_4a55_b86e_6aa716d9a30a
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI191472
name: _AI191472_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_599db810_4d8c_4964_93a7_17c614dcc056
name: DCXR
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:51181
is: Q7Z4W1
constant: false
is: SBO:0000252

metaM nrvnc e
initial concentration: 1.0
type: Species
name: nervonate
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:32392
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: SBO:0000247
is: HMDB02368
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_da0240ae_d4c9_4db0_9ed5_c8f51a692d7a
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1854
name: DUT
is: P33316
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaM ivcrn e
notes: FORMULA: C12H23NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: isovaleryl carnitine
constant: false
is: SBO:0000247
type: Species
is: HMDB00688

metaR FAOXC161802m
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reactant: MODEL1310110058#
name: Beta oxidation fatty acid
is described by: ECO:0000269
kinetic law: MODEL1310110058#
fast: false
reversible: false
product: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110058#_3c0eaf9d_42db_4f8b_bfdc_ce30d2f66374
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: OGDH
constant: false
is encoded by: hsa:4967
is: Q02218
is: SBO:0000252

metaR GLXtm
reactant: MODEL1310110058#
name: glyoxylate transport, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true

metaM leuktrF4 c
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27491
is: HMDB06465

metaR GLCNACPT L
reversible: false
modifier: MODEL1310110058#
fast: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
is version of: http://identifiers.org/ec-code/2.7.8.15
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR CYTK7n
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110058#
reversible: true
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110058#
reactant: MODEL1310110058#
name: cytidylate kinase (CMP,UTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM eicostet c
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1
type: Species
is: HMDB02177
is: SBO:0000247
name: eicosatetranoic acid
constant: false
is: CHEBI:36033
initial concentration: 1.0
has only substance units: false

metaR PSSA1 hs
is version of: http://identifiers.org/ec-code/2.7.8.29
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
name: Phosphatidylserine synthase homo sapiens
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110058#

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR ACACT10m
fast: false
reversible: true
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction

metaR r0470
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_7f4cb04b_b850_4e15_a5ab_eee3048eb868
is encoded by: hsa:55902
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q5QPH3
name: ACSS2

metaM nrvnc c
initial concentration: 1.0
type: Species
constant: false
name: nervonate
initial amount: NaN
has only substance units: false
is: HMDB02368
is: CHEBI:32392
boundary condition: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_c0638979_e658_4a0e_b745_304b9b226ff8
initial amount: NaN
has only substance units: false
type: Species
name: NME1
is: SBO:0000252
is encoded by: hsa:4830
is: P15531
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_a91ff88b_7f4c_4f2c_9d66_2025c92c6089
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5728
name: PTEN
is: F6KD01

metaR PCRNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110058#
name: transport into the mitochondria from cytosol (carnitine)

metaM lys L x
constant: false
is: HMDB00182
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
name: L-lysinium(1+)
initial concentration: 1.0
is: CHEBI:32551

metaR KHte
type: Reaction
is: SBO:0000185
reversible: true
name: KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110058#_25caccfe_07ea_4fe1_b293_ea4ed7924f40
type: Species
is encoded by: hsa:5092
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PCBD1
initial amount: NaN

metaM ivcrn c
has only substance units: false
boundary condition: false
is: HMDB00688
initial concentration: 1.0
name: isovaleryl carnitine
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C12H23NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110058#_186e97c2_a7d6_43d7_afe2_2b21177fac50
has only substance units: false
name: _AI924226_1_m
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AI924226
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_27c6d808_591c_4ea1_bbd8_bf3b289a4b5d
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:11046
name: SLC35D2
boundary condition: true
type: Species
is: Q76EJ3
initial concentration: NaN

metaR 3MOBt2im
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
type: Reaction
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM

metaR ASNCYSNaEx
reversible: false
product: MODEL1310110058#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110058#
is: SBO:0000185
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
fast: false

metaM glu L c
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00148
initial concentration: 1.0
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_92e95c01_89f7_46cd_bde6_37510647e56f
name: MECR
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:51102
initial concentration: NaN
initial amount: NaN
is: Q9BV79

http://identifiers.org/biomodels.db/MODEL1310110058#_e1ac23c5_63fd_4097_9652_fa0a93a34cc3
is: SBO:0000252
is encoded by: hsa:8528
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: DDO
constant: false
boundary condition: true

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaM cs a deg1 l
constant: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
initial concentration: 1.0
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial amount: NaN
has only substance units: false
is: HMDB01354
is: CHEBI:57455
boundary condition: false
type: Species

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_d9bf3302_de79_4db7_a7cb_72a5d65f02e4
boundary condition: true
is: Q05932
initial concentration: NaN
has only substance units: false
constant: false
name: FPGS
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2356
type: Species

metaM HC01104 e
boundary condition: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
name: 4-nitrophenyl phosphate(2-)
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:61146
initial concentration: 1.0

metaM glu5sa m
initial concentration: 1.0
is: C01165
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17232
constant: false
boundary condition: false
is: SBO:0000247
name: L-Glutamate 5-semialdehyde
is: HMDB02104

metaR NDPK10
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110058#
type: Reaction
reversible: true
fast: false
product: MODEL1310110058#
name: nucleoside-diphosphate kinase (ATP:dIDP)
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110058#

metaR Coqe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
is described by: ECO:0000134
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of q10

metaM tettet6coa x
is: HMDB06516
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
boundary condition: false
is: SBO:0000247
constant: false
is: C16171
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/47205481
initial concentration: 1.0
name: tetracosatetraenoyl coenzyme A
initial amount: NaN

metaR CYTDK2m
reversible: false
type: Reaction
name: cytidine kinase (ATP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176

metaR LNLNCACRNt
kinetic law: MODEL1310110058#
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: false
is: SBO:0000185
modifier: MODEL1310110058#

metaR TYRCBOX
name: L-Tyrosine carboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110058#
is described by: ECO:0000134
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
type: Reaction

metaR RE1517M
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
product: MODEL1310110058#
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
reversible: true

metaR r1756
reversible: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_34d01615_f073_403c_b3ae_54e0161ed204
name: NDUFC2
constant: false
is: Q549M5
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:4718
initial amount: NaN

metaR GLCt4
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110058#
type: Reaction
name: glucose transport via sodium symport
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_8548ea0b_f57f_46f0_b98c_40c5510db10a
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:55229
name: PANK4
is: Q9NVE7
has only substance units: false
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_6dfed73f_87b4_4a76_8f7c_855c6894bd4c
initial concentration: NaN
type: Species
name: NDUFA6
is encoded by: hsa:4700
is: P56556
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_c986e72b_88af_4460_acbc_c54319f278ba
is: P06858
name: LPL
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4023
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_a94017a8_73fc_45ed_8fec_52731dac10b3
constant: false
type: Species
name: MTMR3
initial concentration: NaN
is encoded by: hsa:8897
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM 56dthm m
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
name: 5,6-dihydrothymine
is: CHEBI:27468
is: HMDB00079
initial concentration: 1.0

metaM ser L e
type: Species
initial concentration: 1.0
has only substance units: false
name: L-serine
is: HMDB00187
is: CHEBI:17115
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
constant: false
initial amount: NaN

metaM arachd e
type: Species
constant: false
has only substance units: false
is: HMDB01043
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:32395
initial amount: NaN
name: arachidonate

metaR r0603
is described by: ECO:0000000
reactant: MODEL1310110058#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
fast: false
type: Reaction
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:

metaM glu L e
initial amount: NaN
has only substance units: false
is: HMDB00148
is: CHEBI:29985
boundary condition: false
constant: false
initial concentration: 1.0
name: L-glutamate(1-)
is: SBO:0000247
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaM HC01376 m
is: SBO:0000247
constant: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
is: CHEBI:28692
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR C3STKR2r
is described by: ECO:0000134
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110058#
name: C-3 sterol keto reductase (zymosterol)
product: MODEL1310110058#
reversible: false
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
reactant: MODEL1310110058#

metaM lgnccoa x
name: lignocericyl coenzyme A
is: HMDB06526
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ecc5d590_90c0_4757_ba10_1d3f83168fee
is: SBO:0000252
constant: false
initial amount: NaN
name: NDUFB11
is: Q9NX14
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54539

http://identifiers.org/biomodels.db/MODEL1310110058#_bf9e6beb_c3d4_4d83_b532_d7cb85a68e62
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: DPM1
constant: false
is encoded by: hsa:8813
initial concentration: NaN
is: O60762
is: SBO:0000252

metaM glx x
name: glyoxylate
is: CHEBI:36655
is: SBO:0000247
is: HMDB00119
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_4c62f2f9_0610_451b_b1d6_001eb1fd6712
initial concentration: NaN
constant: false
name: ALDH1B1
is encoded by: hsa:219
boundary condition: true
type: Species
is: P30837
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM arachd c
is: CHEBI:32395
is: HMDB01043
has only substance units: false
name: arachidonate
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110058#_86b3a163_1ac8_4d1d_9ea1_70a7b65a38ae
has only substance units: false
is encoded by: hsa:400410
constant: false
type: Species
initial concentration: NaN
name: ST20
initial amount: NaN
is: Q9HBF5
boundary condition: true
is: SBO:0000252

metaR RE3241R
reactant: MODEL1310110058#
is described by: ECO:0000000
name: RE3241
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110058#
modifier: MODEL1310110058#

metaM ethamp r
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
is: HMDB00224
name: O-phosphonatoethanaminium(1-)
is: SBO:0000247
has only substance units: false
is: CHEBI:58190

metaR GLCNACT L
reactant: MODEL1310110058#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
fast: false
product: MODEL1310110058#
type: Reaction

metaM adrn c
initial concentration: 1.0
constant: false
name: adrenic acid
boundary condition: false
is: CHEBI:53487
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR HMGLx
reversible: false
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000134
reactant: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/4.1.3.4
name: hydroxymethylglutaryl-CoA lyase
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102

metaR MAN6PI
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/5.3.1.8
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110058#
type: Reaction
name: mannose-6-phosphate isomerase
modifier: MODEL1310110058#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:

metaM 3oddcoa x
initial amount: NaN
is: CHEBI:27868
is: HMDB03937
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: 3-Oxododecanoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial concentration: 1.0
has only substance units: false

metaM ksi pre35 g
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 35
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0

metaM mmcoa S m
name: (S)-methylmalonyl-CoA(5-)
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
initial amount: NaN
is: CHEBI:57327
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB02310

http://identifiers.org/biomodels.db/MODEL1310110058#_ad6140f2_9d8f_4fb5_8104_6916e8fa75c3
initial amount: NaN
is: P02730
constant: false
name: SLC4A1
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:6521
is: SBO:0000252

metaR FUMSO3tm
reversible: true
name: Fumarate:sulfite antiport, mitochondrial
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000269
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110058#
modifier: MODEL1310110058#

metaM acgagbside hs l
is: HMDB01659
name: alpha GalNAc globoside
type: Species
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
initial concentration: 1.0
is: CHEBI:15347
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_46823265_29d7_4323_84f7_354fd958599b
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1798
initial concentration: NaN
name: DPAGT1
has only substance units: false
type: Species
initial amount: NaN

metaR ACITL
fast: false
is: SBO:0000176
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.3.8
type: Reaction
name: ATP-Citrate lyase
modifier: MODEL1310110058#

metaM ser L c
initial amount: NaN
constant: false
has only substance units: false
name: L-serine
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
is: CHEBI:17115
boundary condition: false
is: SBO:0000247

metaM leuktrF4 e
initial concentration: 1.0
initial amount: NaN
is: HMDB06465
is: SBO:0000247
boundary condition: false
is: CHEBI:27491
name: leukotriene F4
has only substance units: false
type: Species
constant: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1

metaR AHC
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
reactant: MODEL1310110058#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.3.1.1
type: Reaction
name: adenosylhomocysteinase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reversible: true

metaR RE2799C
product: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
fast: false
type: Reaction
name: RE2799
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is: SBO:0000176
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_ecf8bfd1_b2ea_4f31_92c5_8c2c1d02ebb4
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:126129
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q8TCG5
name: CPT1C

http://identifiers.org/biomodels.db/MODEL1310110058#_8625f9cc_95c4_4e2a_8493_1e60482d9995
type: Species
boundary condition: true
constant: false
is: P51828
is: SBO:0000252
has only substance units: false
is encoded by: hsa:113
initial concentration: NaN
initial amount: NaN
name: ADCY7

metaR ALAt4
is described by: ECO:0000269
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
name: Alanine-Sodium symporter
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
fast: false
modifier: MODEL1310110058#
reversible: false

metaM mal L x
initial concentration: 1.0
initial amount: NaN
name: (S)-malate(2-)
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB00156
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaM dutp n
name: dUTP
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:17625
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ad2ca5a3_802d_4fb7_8e98_887228115286
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:9154
boundary condition: true
name: SLC28A1
initial concentration: NaN
is: O00337
type: Species

metaM adrn e
is: CHEBI:53487
is: SBO:0000247
type: Species
is: HMDB02226
constant: false
has only substance units: false
initial concentration: 1.0
name: adrenic acid
initial amount: NaN
boundary condition: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110058#_75091a0c_ab22_4203_9bf4_04875d72eb95
is: Q16850
constant: false
is encoded by: hsa:1595
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CYP51A1

metaM galgluside hs g
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
name: galactosyl glucosyl ceramide
is: CHEBI:58223
has only substance units: false
type: Species
is: HMDB00295
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: C00015

http://identifiers.org/biomodels.db/MODEL1310110058#_4fdc157c_ace1_40af_819b_f9307a66fe00
initial amount: NaN
has only substance units: false
is encoded by: hsa:1807
type: Species
boundary condition: true
is: SBO:0000252
name: DPYS
initial concentration: NaN
constant: false
is: Q14117

metaR r0604
is described by: ECO:0000000
kinetic law: MODEL1310110058#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
modifier: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reversible: false

metaM eicostet e
initial amount: NaN
is: CHEBI:36033
is: SBO:0000247
name: eicosatetranoic acid
notes: FORMULA: C20H31O2 CHARGE: -1
is: HMDB02177
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
constant: false

metaM hmgcoa x
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: HMDB01375

metaR C142CPT1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR r2416
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is: SBO:0000185
product: MODEL1310110058#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ba44b6c4_17c8_4e6f_9e67_cfc8bb3a9740
constant: false
has only substance units: false
is encoded by: hsa:27068
name: PPA2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: F8WDN9
initial amount: NaN
type: Species

metaR UMPK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
product: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: UMP kinase (dATP)
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110058#

metaR RE3624M
name: RE3624
kinetic law: MODEL1310110058#
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110058#
fast: false

metaR GLYC3Ptmc
fast: false
product: MODEL1310110058#
name: glycerol-3-phopshate transport, cytoplasm
reversible: true
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110058#_58472410_8160_4af2_bade_d15f678b8743
boundary condition: true
is encoded by: hsa:4711
has only substance units: false
is: O43674
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: NDUFB5

metaM HC02206 e
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57399
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
has only substance units: false
name: prostaglandin C1(1-)
initial concentration: 1.0

metaM cdpchol c
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01413
name: CDPcholine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
boundary condition: false
is: CHEBI:16436
constant: false

metaM pyr e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: pyruvate
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN
is: CHEBI:15361
constant: false
is: HMDB00243

http://identifiers.org/biomodels.db/MODEL1310110058#_0794967d_4f32_451e_9b7f_bab7f01f41de
name: SLC2A3
is: P11169
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6515
initial amount: NaN
type: Species
constant: false

metaM HC02203 e
name: prostaglandin-a2
type: Species
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false

metaR SPC HSt
reversible: true
kinetic law: MODEL1310110058#
name: sphingosylphosphorylcholine transport (diffusion)
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_41966813_6dbd_4ac0_99ad_502fb48324d5
boundary condition: true
type: Species
is: Q9NUB1
initial amount: NaN
has only substance units: false
name: ACSS1
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:84532

metaM 7dhchsterol c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17759
name: cholesta-5,7-dien-3beta-ol
has only substance units: false
is: HMDB00032
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaR r0488
is described by: ECO:0000000
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#

metaR PROSTGE1t
type: Reaction
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110058#
is described by: ECO:0000269
reactant: MODEL1310110058#

metaM HC01231 m
name: N-[(R)-pantothenoyl]-L-cysteinate
boundary condition: false
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:58480
has only substance units: false
initial concentration: 1.0

metaM lac D e
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16004
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
type: Species
initial concentration: 1.0
is: HMDB01311
constant: false
name: (R)-lactate
has only substance units: false

metaR UMPK6
kinetic law: MODEL1310110058#
is described by: ECO:0000269
reactant: MODEL1310110058#
name: UMP kinase (dCTP)
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110058#
reversible: true
product: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_95661ccd_ac0b_4bea_8c42_a5c4db5ddd1a
initial amount: NaN
is: P53597
has only substance units: false
is: SBO:0000252
name: SUCLG1
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:8802

metaM thbpt c
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:15372
is: HMDB00027
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: 5,6,7,8-tetrahydrobiopterin

metaR P45011A1m
reversible: false
fast: false
kinetic law: MODEL1310110058#
type: Reaction
name: Cytochrome P450 11A1, mitochondrial [Precursor]
reactant: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.15.6
product: MODEL1310110058#
is described by: ECO:0000269

metaM m4masn g
initial amount: NaN
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
is: C05881
notes: FORMULA: C46H77N2O35X CHARGE: 0
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false

metaR UGLT
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
reactant: MODEL1310110058#
is described by: ECO:0000000
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.7.12
name: UDPglucose--hexose-1-phosphate uridylyltransferase

metaR FACOAL160i
reactant: MODEL1310110058#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C160 fatty acid activation
fast: false
reversible: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
product: MODEL1310110058#

metaM thymd m
is: SBO:0000247
is: HMDB00273
constant: false
name: Thymidine
boundary condition: false
is: CHEBI:17748
is: C00214
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214

metaR DASPO1p
is described by: ECO:0000269
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000176
name: D-aspartate oxidase, peroxisomal
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.4.3.1
type: Reaction
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110058#_1a2c0a96_91e2_475b_8e13_bb2fb8af5e31
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4718
is: Q549M5
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: NDUFC2

http://identifiers.org/biomodels.db/MODEL1310110058#_6f39d634_1a73_44e8_bda3_46d3b6b1f99e
initial amount: NaN
has only substance units: false
is encoded by: hsa:89874
type: Species
initial concentration: NaN
constant: false
is: G3V4L5
name: SLC25A21
is: SBO:0000252
boundary condition: true

metaM HC02203 c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
type: Species
name: prostaglandin-a2
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:27820

metaR UMPK7
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
modifier: MODEL1310110058#
name: UMP kinase (dGTP)
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176

metaR NAt3 1
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
type: Reaction
name: sodium proton antiporter (H:NA is 1:1)
is described by: ECO:0000269
kinetic law: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR

metaM gly c
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:3339
constant: false
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
name: Glycine
is: C00037
is: SBO:0000247
type: Species
is: HMDB00123

metaR MGSA2
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
is: SBO:0000176
reactant: MODEL1310110058#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: methyglyoxylate synthase 2 (from g3p)

http://identifiers.org/biomodels.db/MODEL1310110058#_2108f5e6_a8ec_4a8c_a599_9239a6ee9795
boundary condition: true
name: ACADL
type: Species
is: P28330
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:33

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM 2decdicoa m
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
name: 2,7-decadienoylcoa
is: SBO:0000247

metaR r1109
type: Reaction
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reversible: true
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_8ccfae89_1296_425b_b622_4d00310e4cf9
name: GCDH
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2639

http://identifiers.org/biomodels.db/MODEL1310110058#_f4dbeaff_98ef_48c6_9237_76911ad49210
initial concentration: NaN
boundary condition: true
constant: false
is: P15289
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: ARSA
is encoded by: hsa:410

metaM biocyt e
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB03134
is: C05552
name: Biocytin
type: Species
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

metaR IPDPtx
is described by: ECO:0000134
kinetic law: MODEL1310110058#
type: Reaction
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
name: Isopentenyl diphosphate transport (peroxisome)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:

metaR PAPStg
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
name: 3'-Phosphoadenylyl sufate Golgi transport
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110058#
reversible: true

metaM sphings c
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
name: sphingosine(1+)
type: Species
is: CHEBI:57756
initial amount: NaN
boundary condition: false
is: HMDB00252

metaR MANtly
reversible: false
name: mannose efflux from lysosome
fast: false
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD

metaR THRGLNNaEx
product: MODEL1310110058#
is: SBO:0000185
reversible: false
type: Reaction
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
is described by: ECO:0000269
modifier: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_52c7f4cc_830b_423b_8b76_1f9c5cbf019e
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P56134
constant: false
initial amount: NaN
name: ATP5J2
boundary condition: true
is encoded by: hsa:9551
type: Species

metaR ALAGLNNaEx
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM bilirub c
boundary condition: false
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
constant: false
initial concentration: 1.0
name: bilirubin(2-)
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00054

metaM ksi pre14 g
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 14
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
is: CHEBI:28067
type: Species

metaM ksii core2 e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:17268
name: keratan sulfate II (core 2-linked)
type: Species
is: HMDB00211

metaM xylu L c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
boundary condition: false
name: L-xylulose
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:17399
is: HMDB00751
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_67c5c278_ef28_4bbb_89f8_091083a83b74
is: SBO:0000252
type: Species
name: ACO2
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q99798
initial amount: NaN
is encoded by: hsa:50

metaR FAOXC2051843m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110058#
name: Beta oxidation of fatty acid
reactant: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
type: Reaction

metaR G6PDH2rer
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#

metaR RE2660N
modifier: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
name: RE2660
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR IDOURtly
fast: false
name: iduronate transport into lysososme
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_cf84fb33_7a11_49ad_8f7e_2443097d4ae8
type: Species
initial concentration: NaN
name: CTPS2
constant: false
is: Q9NRF8
is: SBO:0000252
is encoded by: hsa:56474
has only substance units: false
initial amount: NaN
boundary condition: true

metaM HC02214 e
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR EX acgam LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-D-glucosamine exchange
type: Reaction

metaR HOMt4
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
product: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
name: L-homoserine via sodium symport
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#

metaM thmmp m
constant: false
boundary condition: false
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
type: Species
initial concentration: 1.0
initial amount: NaN
name: thiamine(1+) monophosphate(2-)
is: SBO:0000247
is: CHEBI:37575
is: HMDB02666
has only substance units: false

metaR RE1254C
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
type: Reaction
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: RE1254
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#

metaM cl e
boundary condition: false
initial amount: NaN
is: CHEBI:3966
name: Chloride
constant: false
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
has only substance units: false
is: C00115
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR NH4tp
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: ammonia peroxisomal transport
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR CYSTALArBATtc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_4c05a590_caa0_4f15_b816_cb9e646e0d16
initial amount: NaN
is encoded by: hsa:7084
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: O00142
name: TK2
is: SBO:0000252

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_e848f768_5f53_4033_81a5_f36b77ff9ea2
boundary condition: true
initial amount: NaN
constant: false
name: APRT
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:353
is: P07741
type: Species

metaR UMPK2
name: UMP kinase (CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
is: SBO:0000176
product: MODEL1310110058#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_7e406693_b107_46d4_9a23_16a3dce468ab
initial amount: NaN
type: Species
name: ATP5J2
is encoded by: hsa:9551
has only substance units: false
constant: false
is: F8W7V3
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM glx c
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00119
name: glyoxylate
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:36655
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_3133343a_0bb2_44d4_9fd0_27ce8a8f0e72
name: HIBADH
is: P31937
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:11112
is: SBO:0000252

metaM HC01405 m
initial amount: NaN
name: (S)-Hydroxyoctanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
boundary condition: false
is: CHEBI:28632
type: Species
has only substance units: false

metaM 35cgmp c
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: CHEBI:57746
is: SBO:0000247
boundary condition: false
is: HMDB01314
name: 3',5'-cyclic GMP(1-)
has only substance units: false

metaM 3hmp m
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoate
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:11805
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
constant: false
is: HMDB00023
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_77606c49_5b73_4a71_9ae9_b0f6390800df
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1583
is: G3XAD7
name: CYP11A1
has only substance units: false
boundary condition: true

metaM bilirub e
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57977
has only substance units: false
constant: false
boundary condition: false
type: Species
is: SBO:0000247

metaM HC02214 c
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
type: Species
is: CHEBI:28852
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f1alpha
constant: false
is: SBO:0000247

metaR UMPK3
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
name: UMP kinase (UTP)
is described by: ECO:0000269

metaR C226CRNt
reversible: false
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: C226 transport into the mitochondria
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM glu L l
name: L-glutamate(1-)
is: HMDB00148
type: Species
is: CHEBI:29985
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
boundary condition: false

metaM arachd l
is: SBO:0000247
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB01043
name: arachidonate

metaR DURIK1
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
reversible: false
modifier: MODEL1310110058#
is described by: ECO:0000254
is: SBO:0000176
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
name: deoxyuridine kinase (ATP:Deoxyuridine)
is version of: http://identifiers.org/ec-code/2.7.1.21

metaR DM 13 cis oretn n
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-oxo-retinoic acid demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_9b6aa35a_a441_44a2_8ead_76b5b3f063fc
initial amount: NaN
has only substance units: false
name: B4GALT1:LALBA
is encoded by: hsa:3906
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has part: P00709
is: SBO:0000297

metaR DMNONCOACRNCPT1
reversible: true
name: DMNONCOACRNCPT1
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110058#

metaR EX 3ddcrn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaM glyc3p m
initial concentration: 1.0
is: CHEBI:57597
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
is: HMDB00126
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: Glycerol 3-phosphate
is: C00093

metaM HC02206 c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: SBO:0000247
name: prostaglandin C1(1-)
is: CHEBI:57399
has only substance units: false
type: Species

metaR AG13T1g
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110058#
reversible: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110058#
reactant: MODEL1310110058#
fast: false

metaM pyr c
constant: false
is: SBO:0000247
is: HMDB00243
boundary condition: false
name: pyruvate
is: http://identifiers.org/pubchem.compound/3324
type: Species
is: C00022
notes: FORMULA: C3H3O3 CHARGE: -1
is: CHEBI:15361
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR UMPK4
type: Reaction
modifier: MODEL1310110058#
is described by: ECO:0000269
name: UMP kinase (GTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110058#
reversible: true
product: MODEL1310110058#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_eded6fb9_ce58_459e_ad31_5031c1dea7c8
boundary condition: true
is: SBO:0000252
name: ACAT2
constant: false
is encoded by: hsa:39
has only substance units: false
type: Species
initial concentration: NaN
is: Q9BWD1
initial amount: NaN

metaM cl c
boundary condition: false
type: Species
is: SBO:0000247
name: Chloride
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
has only substance units: false
is: CHEBI:3966
constant: false
is: HMDB00492
initial concentration: 1.0
is: C00115

metaR NH4tn
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110058#
reversible: true
product: MODEL1310110058#
name: ammonia nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110058#_7c2d23d9_7da7_4564_9da8_dd2b2f8601f5
name: EHHADH
is encoded by: hsa:1962
constant: false
type: Species
is: SBO:0000252
is: Q9NY65
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM ksii core2 pre6 g
is: SBO:0000247
notes: FORMULA: C61H98N5O46SX CHARGE: -2
boundary condition: false
constant: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 6
type: Species
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_a4bc275a_3643_426a_9bcf_306eb505fec5
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4357
is: P25325
initial concentration: NaN
name: MPST

metaR P45027A14m
reactant: MODEL1310110058#
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
is described by: ECO:0000269
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ

metaM glu L m
initial concentration: 1.0
type: Species
name: L-glutamate(1-)
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00148
is: SBO:0000247
is: CHEBI:29985

http://identifiers.org/biomodels.db/MODEL1310110058#_6796ff36_e0bc_41d7_88ad_f5ca90c4da6c
initial amount: NaN
constant: false
name: TKT
is: SBO:0000252
initial concentration: NaN
is: E7EPA7
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:7086

metaR SUBERCROT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_8d018e9c_2445_48ad_ab3d_5b0defaf926f
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: ADCY6
boundary condition: true
is encoded by: hsa:112
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_026eb16c_69bc_42fa_8306_69165cd607f3
boundary condition: true
initial amount: NaN
is encoded by: hsa:5315
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: PKM2
is: P14618
type: Species

metaR SIAT4Bg
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus

metaM 35cgmp e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57746
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: HMDB01314
boundary condition: false
name: 3',5'-cyclic GMP(1-)
type: Species
constant: false

metaR r2086
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110058#
fast: false
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR GLYCt
product: MODEL1310110058#
is described by: ECO:0000000
name: glycerol transport via channel
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110058#
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_d005b9bc_8163_472f_bee7_314053ae38a6
name: GOT1
is encoded by: hsa:2805
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: P17174
initial concentration: NaN

metaR It
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110058#
name: Iodide uniport

metaM pristcoa c
is: CHEBI:51341
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: pristanoyl coa
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2

metaM dcyt n
initial amount: NaN
has only substance units: false
is: HMDB00014
initial concentration: 1.0
name: 2'-deoxycytidine
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:15698
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaR SUCCACT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_41e061f9_c0ea_4f1f_ab87_6bf182ed26ae
name: PLD2
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O14939
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5338

metaM thymd c
is: HMDB00273
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:17748
has only substance units: false
boundary condition: false
name: Thymidine
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: SBO:0000247
type: Species

metaM arachd r
name: arachidonate
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01043

metaM nrpphr e
is: SBO:0000247
type: Species
name: Norepinephrine
constant: false
boundary condition: false
has only substance units: false
is: HMDB00216
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial concentration: 1.0
is: CHEBI:33569
initial amount: NaN

metaM dgsn c
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB00085
boundary condition: false
is: CHEBI:17172
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
name: Deoxyguanosine
is: SBO:0000247

metaR UAG2EMAi
is described by: ECO:0000269
kinetic law: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
product: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
is version of: http://identifiers.org/ec-code/5.1.3.14
fast: false
type: Reaction
reactant: MODEL1310110058#

metaM so4 e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: sulfate
initial amount: NaN
type: Species
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
constant: false

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR r2087
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaM hexdicoa r
is: HMDB00672
boundary condition: false
name: hexadecanedioylcoa
constant: false
initial amount: NaN
initial concentration: 1.0
is: C08260
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_118746a3_4906_4c30_ba67_9fa5a5db10f4
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q53Y41
initial amount: NaN
name: DDC
boundary condition: true
is encoded by: hsa:1644
has only substance units: false

metaM m4mpdol L r
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:37633
constant: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_8cb03d99_32be_49cd_8fb3_45b967960adc
is encoded by: hsa:491
initial concentration: NaN
is: Q4J699
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: ATP2B2
type: Species
has only substance units: false

metaM dec47dicoa m
initial amount: NaN
name: 4,7-decadienoylcoa
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

metaR r0512
modifier: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
product: MODEL1310110058#

metaM glyc3p x
boundary condition: false
initial concentration: 1.0
name: Glycerol 3-phosphate
initial amount: NaN
has only substance units: false
is: HMDB00126
type: Species
is: SBO:0000247
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
constant: false

metaR r0911
is described by: ECO:0000000
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
name: Facilitated diffusion
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

metaR r0377
reversible: false
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_274d7dd6_0c04_4452_bc45_a33b4a36da04
is encoded by: hsa:AL048840
name: _AL048840_1_c
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR COt
fast: false
product: MODEL1310110058#
name: CO transporter via diffusion
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV

metaR VACCt
reversible: true
name: fatty acid transport via diffusion
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false

metaR XAO2x
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: xanthine oxidase
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:18538891,PMID:18538892 NOTES:IT EC 1.17.3.2. Thought to have a role in conversion of purine to allantoin which may not be relevant in humans
product: MODEL1310110058#

metaR r2084
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
reversible: true
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_5ffd05d1_18c7_429f_91b5_ddf701e67369
name: NDUFB3
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4709
is: Q6IB80

metaR r1847
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_9340b07d_608f_4fc1_ab84_79a9626aad61
is encoded by: hsa:137872
is: SBO:0000252
has only substance units: false
constant: false
name: ADHFE1
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q8IWW8
type: Species

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR S6T15g
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is: SBO:0000176
fast: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000

metaM ksii core2 g
type: Species
is: HMDB01644
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:17140
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
constant: false
name: keratan sulfate II (core 2-linked)

metaR PTDCAt
kinetic law: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reactant: MODEL1310110058#
reversible: true
name: fatty acid transport via diffusion

metaM glc D c
is: CHEBI:4167
initial amount: NaN
type: Species
constant: false
is: HMDB00122
is: SBO:0000247
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM bhb m
is: HMDB00011
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaM thymd e
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
name: Thymidine
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: CHEBI:17748
is: C00214
is: SBO:0000247
is: HMDB00273

metaM nrpphr c
initial amount: NaN
name: Norepinephrine
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
constant: false
initial concentration: 1.0
is: HMDB00216
is: CHEBI:33569

metaM HC01231 c
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
is: CHEBI:58480

metaR THCHOLSTOICtm
reactant: MODEL1310110058#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110058#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is: SBO:0000185

metaR O2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, endoplasmic reticulum
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110058#
type: Reaction

metaM ksi pre2 g
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 2
is: CHEBI:58053
is: C00130
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM glu L r
name: L-glutamate(1-)
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
type: Species
boundary condition: false
is: CHEBI:29985
initial concentration: 1.0
is: HMDB00148
initial amount: NaN
has only substance units: false

metaM dhlam m
is: SBO:0000247
is: HMDB00985
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17694
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false
type: Species
name: dihydrolipoamide

metaM glx m
type: Species
has only substance units: false
is: CHEBI:36655
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN
is: HMDB00119
is: SBO:0000247
name: glyoxylate

metaR r2085
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110058#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1846
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110058#

metaR DM fol
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaM c101coa c
constant: false
name: decenoylcoa
type: Species
is: HMDB00651
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM so4 c
is: HMDB01448
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
name: sulfate
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_d1153e5c_5fc5_45ac_ac3d_d549e557f0db
is encoded by: hsa:26
name: ABP1
is: P19801
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR GLYCTDle
name: difussion of glycerol accross the brush border membrane
reversible: true
is: SBO:0000185
product: MODEL1310110058#
is described by: ECO:0000134
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaM acnamp c
is: CHEBI:27438
name: N-Acetylneuraminate 9-phosphate
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB06268
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241

metaR r0913
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110058#
reactant: MODEL1310110058#

metaR NCKt
reversible: true
name: Na+/Ca2+-K+ exchange
is described by: ECO:0000269
modifier: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaR r2082
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_684d6fe7_c65e_4527_b61c_6b309dba40c8
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:2585
is: Q01415
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GALK2

http://identifiers.org/biomodels.db/MODEL1310110058#_c765803d_f42e_4499_bae7_37b00d38af24
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: P04844
name: RPN2
is encoded by: hsa:6185
boundary condition: true

metaR r2202
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000000
product: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110058#

metaM 5adtststerones e
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
constant: false

metaM gly e
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Glycine
is: CHEBI:3339
is: HMDB00123
is: C00037

metaR ASNSERNaEx
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000269
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
reversible: false
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR FOLt2le
is: SBO:0000185
product: MODEL1310110058#
name: folate transport via anion exchange
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
reversible: true

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR 6HTSTSTERONEte
kinetic law: MODEL1310110058#
name: hydroxylated testosterone transport
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, inactivated testosterone needs to be exported NJ
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
type: Reaction

metaM udpg r
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
type: Species
is: HMDB00286
has only substance units: false
is: CHEBI:58367
is: SBO:0000247

metaM glc D e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:4167
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
name: D-glucose

http://identifiers.org/biomodels.db/MODEL1310110058#_09c68620_3156_4c85_9d9c_5e64f4ea9361
type: Species
is encoded by: hsa:196951
is: SBO:0000252
is: Q96M60
initial amount: NaN
name: C15orf33
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_784a06a5_c763_4f72_b75c_e954f3378cae
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:9791
is: P48651
initial concentration: NaN
name: PTDSS1
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_cb4fdc35_6cd4_4650_b0b0_82cc51c315c7
initial amount: NaN
is encoded by: hsa:6476
initial concentration: NaN
is: SBO:0000252
name: SI
constant: false
boundary condition: true
has only substance units: false
type: Species
is: P14410

metaR PPDOy
modifier: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
kinetic law: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
product: MODEL1310110058#
fast: false
is described by: ECO:0000269

metaR INSt
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
fast: false
is described by: ECO:0000269
name: Inosine transport (diffusion)

metaR r2083
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#

metaR DHCHOLESTANATEtm
reactant: MODEL1310110058#
reversible: true
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110058#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
fast: false

metaR DCYTDn
product: MODEL1310110058#
type: Reaction
name: deoxycytidine deaminase, nuclear
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.5
fast: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110058#_eabf8b16_6184_4a4a_95c5_e3c5cbc5e0c6
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:498
initial concentration: NaN
type: Species
initial amount: NaN
is: A8K092
is: SBO:0000252
name: ATP5A1

metaR DAGt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110058#
name: diacylglycerol transport
type: Reaction
is described by: ECO:0000269
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false

metaR DHORD9
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.5.2
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000269
name: dihydoorotic acid dehydrogenase (quinone10)
kinetic law: MODEL1310110058#
reversible: false
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )

http://identifiers.org/biomodels.db/MODEL1310110058#_eea66b52_2087_4761_baf3_df6c89630caa
type: Species
initial amount: NaN
is: SBO:0000252
name: PDE5A
initial concentration: NaN
is encoded by: hsa:8654
has only substance units: false
constant: false
boundary condition: true
is: O76074

http://identifiers.org/biomodels.db/MODEL1310110058#_66fbb4d6_296e_4933_97d9_2bc0bdd52be7
initial concentration: NaN
constant: false
is encoded by: hsa:107
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q08828
name: ADCY1
boundary condition: true
type: Species

metaM doco13ac e
notes: FORMULA: C22H41O2 CHARGE: -1
type: Species
constant: false
initial concentration: 1.0
name: docosenoic acid (C22:1)
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB02068
is: SBO:0000247

metaR AMETt2m
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
fast: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110058#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_a83f6d45_59da_47de_96a7_14d03bf7c705
type: Species
name: SLC43A2
initial amount: NaN
is: SBO:0000252
is: Q8N370
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:124935

metaR r2080
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_d9e99495_285d_4c36_9b35_e3674e55bc9d
boundary condition: true
is: Q6IBE6
has only substance units: false
name: ST3GAL4
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:6484

metaR r0915
type: Reaction
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110058#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_ea6daa72_5aa7_4679_9d5f_dbc1623c52a0
is: Q9P212
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:51196
type: Species
initial amount: NaN
initial concentration: NaN
name: PLCE1
constant: false

metaR GLCtg
name: glucose transport, Golgi apparatus
reactant: MODEL1310110058#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#

metaM glc D g
is: SBO:0000247
name: D-glucose
initial concentration: 1.0
type: Species
constant: false
is: HMDB00122
is: CHEBI:4167
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaR SERtN1
type: Reaction
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110058#
is described by: ECO:0000269
reactant: MODEL1310110058#
name: Serine transport (Na, H coupled)
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534

http://identifiers.org/biomodels.db/MODEL1310110058#_1b08a29e_edd3_4013_8c0b_5e69f099d348
constant: false
is: O95436
is encoded by: hsa:10568
boundary condition: true
type: Species
name: SLC34A2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r1106
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
name: Postulated transport reaction
type: Reaction
is: SBO:0000185

metaR r2081
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110058#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110058#

metaR SERDGLNexR
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110058#
name: D-Serine/Glutamine reversible exchange
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
product: MODEL1310110058#
type: Reaction

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR CYSSERNaEx
reversible: false
kinetic law: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110058#
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_4b3b1bef_73f7_4988_bab2_0444d2640f2d
boundary condition: true
is encoded by: hsa:AI285872
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: _AI285872_1_c
initial amount: NaN
initial concentration: NaN

metaM dgsn e
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00085
is: CHEBI:17172
initial concentration: 1.0
is: C00330
boundary condition: false
name: Deoxyguanosine
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330

http://identifiers.org/biomodels.db/MODEL1310110058#_8096b28e_dc70_4e8e_b24c_397a1dd9dba6
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: ELOVL5
has only substance units: false
is: F6SH78
type: Species
is encoded by: hsa:60481
initial concentration: NaN

metaM s7p c
is: CHEBI:57483
name: Sedoheptulose 7-phosphate
constant: false
has only substance units: false
is: HMDB01068
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
type: Species
is: C05382
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_f7ca9bc0_12a5_4d5e_99f9_a6596a2c2c7e
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: Q6IRT1
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ADH5
is encoded by: hsa:128

http://identifiers.org/biomodels.db/MODEL1310110058#_ea4a3717_0efa_4cc9_bb26_44c3c62f72cf
boundary condition: true
is: SBO:0000252
is encoded by: hsa:411
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: P15848
constant: false
name: ARSB

http://identifiers.org/biomodels.db/MODEL1310110058#_bb46628f_f763_4b47_aebe_adcb449a7b51
initial concentration: NaN
name: NME1:NME2
constant: false
has part: P22392
initial amount: NaN
is: SBO:0000297
has only substance units: false
boundary condition: true
has part: P15531
type: Species
is encoded by: hsa:4830
is encoded by: hsa:4831

metaR RE2660C
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660

metaM c8crn e
name: octanoyl carnitine
notes: FORMULA: C15H29NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C02838
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: HMDB00791

metaR MI145PP
is version of: http://identifiers.org/ec-code/3.1.3.36
name: inositol-1,4,5-trisphosphate 5-phosphatase
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56

metaM whddca e
is: HMDB02059
name: omega hydroxy dodecanoate (n-C12:0)
initial amount: NaN
type: Species
boundary condition: false
constant: false
notes: FORMULA: C12H23O3 CHARGE: -1 INCHI: InChI=1/C12H24O3/c13-11-9-7-5-3-1-2-4-6-8-10-12(14)15/h13H,1-11H2,(H,14,15)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM 3ivcrn c
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H23NO5 CHARGE: 0
is: SBO:0000247
name: 3-hydroxy-isovaleryl carnitine
type: Species
initial amount: NaN
is: HMDB06870
constant: false
is: C05998

metaM ksi pre36 g
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
constant: false
name: keratan sulfate I biosynthesis, precursor 36
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110058#_2cf25cd7_7c63_44d2_b64c_69fb7c208051
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI620219
initial amount: NaN
name: _AI620219_1_e
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_e09e417d_4c1b_4a2b_ae69_5482599f7ab9
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:29968
constant: false
initial concentration: NaN
is: SBO:0000252
name: PSAT1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_c3706dea_cf06_4864_85e8_6a3229d59078
type: Species
is: Q16775
is encoded by: hsa:3029
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: HAGH
initial concentration: NaN
has only substance units: false
constant: false

metaR CITt4 2
name: citrate transport via sodium symport
reactant: MODEL1310110058#
is described by: ECO:0000269
product: MODEL1310110058#
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_e26c90f8_ea03_47d6_99b1_7f687f0c870b
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:8871
type: Species
has only substance units: false
boundary condition: true
name: SYNJ2
is: O15056

metaM c10dc x
constant: false
boundary condition: false
is: HMDB00651
notes: FORMULA: C17H30NO6 CHARGE: -1
has only substance units: false
is: SBO:0000247
name: sebacoyl carnitine
initial concentration: 1.0
type: Species
initial amount: NaN

metaM dcyt e
initial amount: NaN
is: CHEBI:15698
is: SBO:0000247
boundary condition: false
type: Species
name: Deoxycytidine
is: C00881
constant: false
initial concentration: 1.0
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
has only substance units: false
is: HMDB00014

metaM n2m2nmasn e
constant: false
initial amount: NaN
is: C04946
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
type: Species
notes: FORMULA: C58H96N5O40X CHARGE: 0
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_c8b4f322_b106_4afd_bfbe_28537a17a000
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI990637
boundary condition: true
name: _AI990637_1_x
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_0d2bada8_8a92_4005_b203_cd1b47f93feb
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:3158
has only substance units: false
name: HMGCS2
is: P54868
initial concentration: NaN
initial amount: NaN

metaM bhb c
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
is: HMDB00011
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:10983
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_a6e87689_d8a3_44f9_a473_ffe877a1854d
is: SBO:0000252
constant: false
is encoded by: hsa:1120
boundary condition: true
is: Q9Y259
name: CHKB
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM 3ddecdicoa m
is: SBO:0000247
is: C05280
is: HMDB03952
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 3,6-dodecadienoylcoa
type: Species

metaR r0917
reactant: MODEL1310110058#
product: MODEL1310110058#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_176c56eb_9838_4c89_b1ae_f4c38bf46abc
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6818
initial amount: NaN
has only substance units: false
name: SULT1A3
type: Species

metaR SEBACIDTD
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaM CE5160 r
has only substance units: false
name: 3-oxo-cis-9-octadecenoyl-CoA
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57923
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160

metaM acgam r
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
boundary condition: false
is: HMDB00215
name: N-acetyl-D-glucosamine

http://identifiers.org/biomodels.db/MODEL1310110058#_35ae90e9_ffa4_45a2_bdac_fef960110b44
has only substance units: false
is encoded by: hsa:48
boundary condition: true
is: P21399
is: SBO:0000252
constant: false
initial concentration: NaN
name: ACO1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_b56ebb92_5bfd_4c08_b2ba_652c0cd08795
initial concentration: NaN
type: Species
name: MAN1C1
has only substance units: false
is: Q9NR34
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:57134

metaM c8crn c
constant: false
is: HMDB00791
notes: FORMULA: C15H29NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C02838
initial amount: NaN
name: octanoyl carnitine
type: Species

metaM paps g
type: Species
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:58339
initial amount: NaN
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: HMDB01134
is: SBO:0000247
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial concentration: 1.0

metaR DDECE1CRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_da1b9616_840c_4e7a_b555_c072d2aa2cf7
initial amount: NaN
type: Species
is: SBO:0000252
name: ST3GAL3
is encoded by: hsa:6487
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaM 7dhchsterol r
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00032
is: CHEBI:17759
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
name: cholesta-5,7-dien-3beta-ol
initial concentration: 1.0
type: Species

metaR r2201
fast: false
reactant: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110058#
product: MODEL1310110058#

metaR EX doco13ac
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaM dcyt c
is: HMDB00014
is: CHEBI:15698
boundary condition: false
initial amount: NaN
name: Deoxycytidine
is: SBO:0000247
type: Species
has only substance units: false
is: C00881
initial concentration: 1.0
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false

metaM 3ivcrn e
type: Species
notes: FORMULA: C12H23NO5 CHARGE: 0
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 3-hydroxy-isovaleryl carnitine
is: HMDB02068
constant: false

metaR r1850
modifier: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110058#

metaR CITt4 4
name: citrate transport via sodium symport
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
type: Reaction
product: MODEL1310110058#
reversible: true
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000006

http://identifiers.org/biomodels.db/MODEL1310110058#_55266b9b_7a96_454f_85ed_5961da1cf13e
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: Q15392
boundary condition: true
name: DHCR24
is encoded by: hsa:1718

metaM bhb e
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
is: HMDB00011
boundary condition: false
initial amount: NaN
name: (R)-3-hydroxybutyrate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaR ME1m
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110058#
name: malic enzyme (NAD), mitochondrial
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.38

http://identifiers.org/biomodels.db/MODEL1310110058#_b3d3c2f2_1b4e_4315_9427_0285157ef479
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:314
name: AOC2
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR r2200
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
fast: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_9883e2f8_12ca_4655_bca3_74deac3803e1
initial amount: NaN
constant: false
is encoded by: hsa:229
boundary condition: true
type: Species
name: ALDOB
is: P05062
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_26f6e375_2d2d_4190_b806_69d4408854d3
type: Species
initial concentration: NaN
name: UCK1
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:83549
is: Q5JT09

metaR PGDI
modifier: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/2.5.1.18
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is described by: ECO:0000269
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Prostaglandin-H2 D-isomerase [Precursor]
is version of: http://identifiers.org/ec-code/5.3.99.2
type: Reaction
is: SBO:0000176
product: MODEL1310110058#

metaM ipdp x
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
initial concentration: 1.0
is: HMDB01347
name: isopentenyl diphosphate(3-)
has only substance units: false
initial amount: NaN
is: CHEBI:128769

metaM 5adtststerones c
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
has only substance units: false
name: 5alpha-Dihydrotestosterone sulfate
type: Species
boundary condition: false
initial amount: NaN

metaM whddca c
boundary condition: false
initial concentration: 1.0
name: omega hydroxy dodecanoate (n-C12:0)
initial amount: NaN
notes: FORMULA: C12H23O3 CHARGE: -1 INCHI: InChI=1/C12H24O3/c13-11-9-7-5-3-1-2-4-6-8-10-12(14)15/h13H,1-11H2,(H,14,15)
type: Species
is: HMDB02059
is: SBO:0000247
constant: false
has only substance units: false

metaR r0504
reactant: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
modifier: MODEL1310110058#
fast: false
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_2885e45e_dc82_49fb_b81a_3880b2790350
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: ENPP1
type: Species
boundary condition: true
is encoded by: hsa:5167
initial amount: NaN
is: P22413

metaR 7DHFtm
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: false
name: 7-glutamyl-DHF transport,m mitochondrial
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT

http://identifiers.org/biomodels.db/MODEL1310110058#_06410be6_6dd6_44b3_964a_9f5aa6c97935
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B4DFS7
is encoded by: hsa:2530
type: Species
name: FUT8
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_70e203fd_494c_4ba6_a8c0_39be307d7a6b
boundary condition: true
type: Species
name: ATP5J
is: Q6IB54
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:522
initial amount: NaN
constant: false

metaM trp L e
type: Species
is: CHEBI:16828
is: SBO:0000247
has only substance units: false
constant: false
name: L-tryptophan
initial concentration: 1.0
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
boundary condition: false
is: HMDB00929

metaR NADPtru
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
fast: false
name: NADP transporter, endoplasmic reticulum
kinetic law: MODEL1310110058#
reversible: false
type: Reaction
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_2f4825c1_eaa1_41d8_b69b_d1ac5580c1ac
constant: false
is encoded by: hsa:1103
initial amount: NaN
is: SBO:0000252
is: Q6LEN6
has only substance units: false
type: Species
name: CHAT
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_227e5fab_b2f8_475c_b408_c491b448ec90
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:2954
is: SBO:0000252
name: GSTZ1
initial amount: NaN

metaR LINKDEG4ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110058#
fast: false
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR r2079
modifier: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM pristcoa x
initial amount: NaN
boundary condition: false
is: CHEBI:51341
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial concentration: 1.0
name: pristanoyl coa
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaR 7DHFtl
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110058#
name: 7-glutamyl-DHF transport, lysosomal
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT

http://identifiers.org/biomodels.db/MODEL1310110058#_1ed8d89e_10c4_4210_886c_8ff20b08a547
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: AK2
is encoded by: hsa:204
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_7d49bc6a_9ba1_4b5f_a4d9_6b396c8a0b2e
initial amount: NaN
name: GAPDH
type: Species
is encoded by: hsa:2597
is: SBO:0000252
constant: false
is: E7EUT4
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR SCP22x
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
product: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
reactant: MODEL1310110058#
name: Sterol carrier protein 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.176

metaR r2420
product: MODEL1310110058#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
reactant: MODEL1310110058#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_b743f2b8_298f_47c2_8bef_7a7a66d17b01
is encoded by: hsa:1579
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: CYP4A11
is: Q02928

metaR O2t
product: MODEL1310110058#
name: o2 transport (diffusion)
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reactant: MODEL1310110058#

metaR r0502
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.1.113
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
modifier: MODEL1310110058#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
type: Reaction
reversible: true
fast: false

metaM trp L c
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16828
name: L-tryptophan
type: Species
constant: false
is: SBO:0000247
is: HMDB00929

http://identifiers.org/biomodels.db/MODEL1310110058#_cca441b9_a06d_49e4_bd6c_08a543c37e3f
is encoded by: hsa:6535
boundary condition: true
initial concentration: NaN
constant: false
is: B4DIA3
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC6A8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_7e10d8fa_ed2d_446a_bfcc_a6cd7b68a5f9
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: ST8SIA1
initial amount: NaN
is: Q92185
is encoded by: hsa:6489
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_d1af0fbb_d242_48ef_bda7_9673e75858f1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: _AV717590_1_m
has only substance units: false
is encoded by: hsa:AV717590
type: Species

metaR NRVNCt
reactant: MODEL1310110058#
name: fatty acid transport via diffusion
product: MODEL1310110058#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_7ad7b3fa_b97b_4e85_b1ea_73a0188c614d
has only substance units: false
boundary condition: true
constant: false
name: _R33828_1_c
type: Species
is encoded by: hsa:R33828
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_c721874b_f5f2_4b65_8754_ddb69aecf78a
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: CTSA
type: Species
is: P10619
is encoded by: hsa:5476
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_9ea9ece9_9e71_4585_a422_5c492da87ce4
constant: false
is: SBO:0000252
boundary condition: true
name: PIP5K1A
initial concentration: NaN
is: Q99755
has only substance units: false
type: Species
is encoded by: hsa:8394
initial amount: NaN

metaR C101CRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR SEBCOAPET
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_73f1b694_0309_4af2_87e2_5cc57b1de29e
is encoded by: hsa:151531
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O95045
constant: false
has only substance units: false
type: Species
name: UPP2
is: SBO:0000252

metaR GLCAASE9ly
modifier: MODEL1310110058#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110058#
name: beta-glucuronidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false

metaR NACHORCTL3le
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: NACHORCTL3le
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_f2fad22e_7d15_4bf9_9a0d_fce1441d1d2f
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6818
constant: false
is: P50224
type: Species
initial amount: NaN
is: SBO:0000252
name: SULT1A3

metaR THBPT4ACAMDASE
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110058#
reversible: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
kinetic law: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_9b40a44b_7200_4bff_8f8f_a44c349b8c53
has only substance units: false
is encoded by: hsa:5146
constant: false
is: P51160
initial amount: NaN
name: PDE6C
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR PRGSTRNt
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: Progesterone transport
reversible: true

metaM dec24dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
name: 2,4-decadienoylcoa
constant: false
is: HMDB01168
initial concentration: 1.0

metaR IVCOAACBP
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_bbf1a028_a04c_4150_9e45_206521515734
initial concentration: NaN
constant: false
name: MECR
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9BV79
has only substance units: false
is encoded by: hsa:51102

http://identifiers.org/biomodels.db/MODEL1310110058#_32574124_86ec_4998_9994_055947884a76
is encoded by: hsa:6565
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q16348
name: SLC15A2
has only substance units: false

metaR 34HPPOR
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.27
reversible: false
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase

metaR HISD
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.1.3
fast: false
reversible: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000269
name: histidase
reactant: MODEL1310110058#

metaR RE1448N
reactant: MODEL1310110058#
is: SBO:0000176
fast: false
name: RE1448
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true

metaR r0480
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_8e239d23_2622_4991_830f_d8f88340875d
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11181
is: O43280
type: Species
is: SBO:0000252
initial amount: NaN
name: TREH
boundary condition: true

metaM hexdicoa c
has only substance units: false
boundary condition: false
is: HMDB02014
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
name: hexadecanedioylcoa
initial amount: NaN
is: SBO:0000247
type: Species

metaM b2coa m
type: Species
is: CHEBI:57332
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB02009
name: crotonoyl-CoA(4-)
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
constant: false
initial amount: NaN
boundary condition: false

metaR THRSERNaEx
fast: false
reversible: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
type: Reaction
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM HC01610 e
has only substance units: false
boundary condition: false
is: CHEBI:28607
type: Species
is: SBO:0000247
initial amount: NaN
name: CoproporphyrinogenI
initial concentration: 1.0
constant: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768

metaR SERTHRNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110058#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
is: SBO:0000185
fast: false

metaM glc D r
is: HMDB00122
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: D-glucose

metaR OCDCEAtr
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110058#
fast: false
type: Reaction
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110058#
reversible: true

metaR CYTK8n
fast: false
kinetic law: MODEL1310110058#
name: cytidylate kinase (CMP,dATP),nuclear
modifier: MODEL1310110058#
is described by: ECO:0000269
reversible: true
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_513c6d58_7717_49b5_aa62_634950370967
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:AA576959
name: _AA576959_1_c
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaM 4mptnl e
has only substance units: false
is: CHEBI:17998
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 4-methylpentanal
is: HMDB01318
initial concentration: 1.0
boundary condition: false

metaR FE2DMT1
type: Reaction
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
name: uptake of food iron by DMT1 transporter
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (4891.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
modifier: MODEL1310110058#
is: SBO:0000185

metaR RE3242R
name: RE3242
product: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaM n2m2nmasn l
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: C04946
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ea7e9dfc_3a51_41e3_a60f_b37930c89bc3
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q9Y227
constant: false
is encoded by: hsa:9583
type: Species
name: ENTPD4

http://identifiers.org/biomodels.db/MODEL1310110058#_baae7877_9a68_4467_8676_5b4c720b44dd
name: IMPDH1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3614
is: B3KRZ3
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaM gdpddman c
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
is: CHEBI:57964
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
is: HMDB01346

metaR ASCBt4
modifier: MODEL1310110058#
name: L-ascorbate transport via proton symport
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#

metaM 1p3h5c m
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: SBO:0000247
has only substance units: false
is: CHEBI:6151
is: HMDB01369
type: Species
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_d1a11f38_e513_4a79_a2a3_df9b6e722fef
boundary condition: true
is encoded by: hsa:5860
initial concentration: NaN
name: QDPR
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is: P09417

metaR RE1804M
is described by: ECO:0000000
name: RE1804
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
product: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR r0483
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_d49a3024_2da5_44e4_90df_ecad29181ac8
is: SBO:0000252
is encoded by: hsa:79087
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: ALG12
type: Species
initial concentration: NaN
is: Q9BV10

metaR DOLDPP Ler
product: MODEL1310110058#
type: Reaction
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
reactant: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.6.1.43
fast: false

metaR G14Tg
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
fast: false

metaR FRUt4
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000185
fast: false
reactant: MODEL1310110058#
name: D-fructose transport via sodium cotransport
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_b299eddb_9f4c_49e0_8bf1_ac04aaf9be6d
type: Species
has only substance units: false
constant: false
name: AK4
initial concentration: NaN
boundary condition: true
is encoded by: hsa:205
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_12f87482_481b_46fd_9999_b0acbce01cfb
type: Species
is: SBO:0000252
is encoded by: hsa:2530
has only substance units: false
initial amount: NaN
name: FUT8
constant: false
boundary condition: true
is: G3V5N0
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_cd412e07_67c6_4ba3_993d_51e31280f7d2
type: Species
name: GNE
is: SBO:0000252
constant: false
is encoded by: hsa:10020
boundary condition: true
is: B7Z428
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM xol27oh m
initial concentration: 1.0
constant: false
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
name: 26-hydroxycholesterol
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:17703
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_c4e71370_603b_4985_897c_0ea711477375
constant: false
boundary condition: true
is: SBO:0000252
is: P23219
has only substance units: false
type: Species
initial concentration: NaN
name: PTGS1
initial amount: NaN
is encoded by: hsa:5742

metaR BTNt2
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
name: Biotin reversible transport via proton symport
reversible: true
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110058#
is described by: ECO:0000269

metaM udpg c
is: HMDB00286
name: UDPglucose
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species
initial concentration: 1.0
is: C00029
initial amount: NaN
has only substance units: false
is: CHEBI:58367

metaR RE1516M
is described by: ECO:0000000
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
kinetic law: MODEL1310110058#
name: RE1516
is: SBO:0000176

metaM xol27oh r
constant: false
name: 26-hydroxycholesterol
is: HMDB02103
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species
boundary condition: false
is: CHEBI:17703
is: SBO:0000247
initial amount: NaN

metaM aps c
type: Species
is: SBO:0000247
is: CHEBI:58243
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: HMDB01003
constant: false
name: 5'-adenylyl sulfate(2-)
boundary condition: false

metaR FACOAL244 1
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

metaM dcacoa c
has only substance units: false
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
is: HMDB06404
is: C05274

metaM HC02023 r
is: SBO:0000247
constant: false
has only substance units: false
name: Cholesterol-ester-ol
initial concentration: 1.0
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
boundary condition: false
initial amount: NaN
is: CHEBI:46898
type: Species

metaM glyc3p c
name: Glycerol 3-phosphate
is: CHEBI:57597
constant: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00093
is: HMDB00126
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_744a5e4d_0f0a_42ab_bd86_fdac5bca3279
initial concentration: NaN
name: CLC
has only substance units: false
type: Species
is: C5HZ13
is encoded by: hsa:1178
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR PNTEH
is: SBO:0000176
modifier: MODEL1310110058#
fast: false
reversible: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
name: Hydrolase Class ( RXN R02973)
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM

metaR ELAIDt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110058#

metaM 44mctr r
is: HMDB01023
type: Species
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: SBO:0000247
has only substance units: false
is: CHEBI:17813

http://identifiers.org/biomodels.db/MODEL1310110058#_a3d093cd_a856_4399_abbf_38174bfcf0ab
constant: false
initial concentration: NaN
initial amount: NaN
is: Q6FHI7
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:762
name: CA4

metaR 2OXOADOXm
type: Reaction
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
product: MODEL1310110058#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
reversible: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.3.1.61
is described by: ECO:0000304
reactant: MODEL1310110058#

metaR r0616
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM clpndcoa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
name: clupanodonyl CoA
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB06267
is: C16166
is: http://identifiers.org/pubchem.compound/47205476
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM tre e
has only substance units: false
is: CHEBI:16551
is: C01083
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00975
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Trehalose

metaR ALADGLYexR
fast: false
is described by: ECO:0000304
modifier: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: D-alanine/glycine reversible exchange
is: SBO:0000185

metaM lac D c
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: HMDB01311
initial concentration: 1.0
name: (R)-lactate
is: CHEBI:16004
initial amount: NaN
boundary condition: false
type: Species

metaR PGSr
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.99.1
fast: false
type: Reaction
product: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000269
name: Prostaglandin G/H synthase
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
modifier: MODEL1310110058#

metaR LEUTAm
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110058#
name: leucine transaminase, mitochondrial
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110058#
reversible: true

metaR CHATn
name: Choline O-acetyltransferase
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
reactant: MODEL1310110058#

metaM paps c
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01134
is: CHEBI:58339
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
constant: false
is: SBO:0000247

metaM 34hpp e
is: SBO:0000247
has only substance units: false
is: HMDB00707
boundary condition: false
name: 3-(4-hydroxyphenyl)pyruvate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
constant: false
is: CHEBI:36242
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_103bedad_59e8_4603_8527_3114eb97625e
initial amount: NaN
is: Q6LEN5
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:1103
initial concentration: NaN
name: CHAT

metaR DURIt
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
name: deoxyuridine transport via diffusion
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#

metaM 4mptnl c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
constant: false
has only substance units: false
type: Species
is: CHEBI:17998
name: 4-methylpentanal
is: HMDB01318
initial concentration: 1.0
initial amount: NaN

metaM 34hpp c
boundary condition: false
type: Species
has only substance units: false
constant: false
is: HMDB00707
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
initial concentration: 1.0
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate

metaM acgam l
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00215
is: SBO:0000247
name: N-acetyl-D-glucosamine
type: Species
constant: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_4f8f320b_ec36_45f6_b589_18541cb182e0
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: B2RB47
is encoded by: hsa:271
name: AMPD2
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR ABUTD
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
kinetic law: MODEL1310110058#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
name: Aminobutyraldehyde dehydrogenase

metaR Q10H2e
name: transport of ubiquinol into lymph
is: SBO:0000185
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
fast: false
kinetic law: MODEL1310110058#

metaR C141CPT1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR r0614
reversible: true
is: SBO:0000176
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
fast: false

metaR LACZe
is described by: ECO:0000134
fast: false
modifier: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.108
name: b-galactosidase, extracellular
reactant: MODEL1310110058#
reversible: false
product: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_8126f205_0c66_4763_ae1a_ce33f6c7945b
boundary condition: true
initial concentration: NaN
is: Q9GZV3
constant: false
is: SBO:0000252
has only substance units: false
name: SLC5A7
type: Species
initial amount: NaN
is encoded by: hsa:60482

metaM xol7ah2al c
has only substance units: false
initial concentration: 1.0
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: SBO:0000247
boundary condition: false
is: HMDB06894
is: CHEBI:27428
type: Species
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN

metaR r0630
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.3.2

metaR FAOXC226205m
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
modifier: MODEL1310110058#
reversible: false
product: MODEL1310110058#
name: Beta oxidation of long chain fatty acid
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110058#_87d71429_7388_4294_9e01_627ecccf1647
initial concentration: NaN
name: CA6
type: Species
is: Q5FC00
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:765
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_998d94b6_10f8_4451_a338_613af80bb389
boundary condition: true
initial amount: NaN
constant: false
is: Q9Y672
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29929
name: ALG6
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_15c560be_7928_4b4c_bafd_531d4970128e
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:3636
is: O15357
type: Species
initial concentration: NaN
name: INPPL1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_091e0097_c59d_4768_9aa9_0d46ab0d0afd
boundary condition: true
is: F8W682
initial concentration: NaN
constant: false
has only substance units: false
name: SLC4A2
type: Species
is: SBO:0000252
is encoded by: hsa:6522
initial amount: NaN

metaM co e
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: SBO:0000247
is: HMDB01361
initial amount: NaN
is: CHEBI:17245
name: carbon monoxide
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_0370bb35_50f0_463c_8d0b_cfdb34dd45dd
constant: false
is: SBO:0000252
name: HSD3B1
is encoded by: hsa:3283
is: P14060
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_3ff9dee9_0835_4c02_8098_ded19e1a4990
initial amount: NaN
type: Species
is: B4E1R2
has only substance units: false
name: CTH
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1491
initial concentration: NaN
constant: false

metaR DNDPt9m
modifier: MODEL1310110058#
reversible: false
name: dADP transport via dTDP antiport
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_06412418_aa15_48e7_9c49_d5408a67d1cc
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:3033
is: SBO:0000252
is: Q16836
initial concentration: NaN
name: HADH
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_1a9f2c3c_cde3_4b39_9ad1_66bac02c87d3
type: Species
is encoded by: hsa:5152
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: PDE9A
is: SBO:0000252

metaR CO2tp
is described by: ECO:0000000
reactant: MODEL1310110058#
name: CO2 peroxisomal transport
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110058#
fast: false

metaR HMGCOASi
kinetic law: MODEL1310110058#
type: Reaction
name: Hydroxymethylglutaryl CoA synthase (ir)
is described by: ECO:0000269
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: false
modifier: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
is: SBO:0000176

metaM nmn c
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
type: Species
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:14649
is: C00455
name: NMN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00229

metaR r0081
type: Reaction
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
kinetic law: MODEL1310110058#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_34f954ec_3360_4aaf_b7ad_e492b44ad7bb
is encoded by: hsa:221823
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PRPS1L1
is: SBO:0000252
boundary condition: true

metaR r0944
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110058#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
kinetic law: MODEL1310110058#

metaM cs b l
type: Species
is: HMDB02183
is: CHEBI:36005
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
constant: false
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain

http://identifiers.org/biomodels.db/MODEL1310110058#_2374d567_4320_4ef4_9a22_940a8e004112
is encoded by: hsa:8654
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: PDE5A
has only substance units: false
initial concentration: NaN
constant: false
is: G5E9C5

metaR FAOXC18480m
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110058#

metaM 2mop m
is: CHEBI:57700
is: HMDB01172
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 2-methyl-3-oxopropanoate

metaM acgam e
initial amount: NaN
name: N-acetyl-D-glucosamine
is: CHEBI:17411
boundary condition: false
constant: false
has only substance units: false
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_69e95f38_5207_4df0_8c96_d6572e59afc7
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:490
name: ATP2B1
constant: false
is: P20020
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_a6940e74_34a6_41a5_9b42_5bbd3ec8165f
constant: false
type: Species
name: NT5M
has only substance units: false
is: Q9NPB1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:56953
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_44141119_a557_4635_8bcf_8953304f8a8a
is encoded by: hsa:F23536
name: _F23536_1_m
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM xu1p D c
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
boundary condition: false
initial amount: NaN
type: Species
is: HMDB06534
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: D-Xylulose 1-phosphate

metaR ARABR
fast: false
is: SBO:0000176
type: Reaction
name: arabinose reductase
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_dc3941c4_1a13_45b4_8b75_74dcc2f60ac6
is encoded by: hsa:5831
boundary condition: true
constant: false
initial amount: NaN
is: A6NFM2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PYCR1
type: Species

metaR r0941
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: Free diffusion

metaM atp r
type: Species
is: C00002
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: ATP(4-)
is: CHEBI:57299
is: HMDB00538

metaM ficytC m
is: CHEBI:15991
initial amount: NaN
name: Ferricytochrome c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
constant: false
boundary condition: false
is: SBO:0000247
type: Species

metaR C16DCe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_fe94bf0f_6d47_42d1_b4ad_b9cb0a098c57
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:22305
initial concentration: NaN
is: SBO:0000252
name: _22305_1_c
initial amount: NaN

metaM 1pyr5c m
is: HMDB01301
is: SBO:0000247
is: C03912
is: CHEBI:15893
name: 1-Pyrroline-5-carboxylate
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_7c6381fc_6519_4aec_ae76_d2d5497af65a
name: FOLR1
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:2348
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_bd2f7950_3032_4fc3_bf90_164530eb4eeb
has only substance units: false
is: P21912
name: SDHB
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6390

metaR r0083
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110058#
fast: false
type: Reaction

metaR THRCYSNaEx
modifier: MODEL1310110058#
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)

metaR r0497
kinetic law: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.2
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
type: Reaction
reactant: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
fast: false
product: MODEL1310110058#

metaR r0942
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110058#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_1ca13f67_ab81_4385_8553_c220a95a34c3
initial amount: NaN
initial concentration: NaN
name: ADO
has only substance units: false
is: B3KXN9
is encoded by: hsa:84890
boundary condition: true
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_e49f9963_bac2_4a4f_889f_fa790b4f4388
constant: false
initial concentration: NaN
is encoded by: hsa:11001
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC27A2
is: O14975
type: Species
boundary condition: true

metaM pmtcoa c
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
type: Species
is: SBO:0000247
is: C00154
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:3454

metaM dece4coa m
is: HMDB02145
boundary condition: false
has only substance units: false
constant: false
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 4-decenoylcoa

metaM pail45p hs m
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
initial amount: NaN
has only substance units: false

metaR r0633
modifier: MODEL1310110058#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.7.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
product: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_d2d3999f_94b4_42e5_936c_f6894e47cd63
initial concentration: NaN
is: Q6LEN5
is encoded by: hsa:1103
constant: false
name: CHAT
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR TMNDNCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110058#
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110058#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_993ab24e_9d86_4e59_bbf3_3239f6cd47a3
constant: false
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
initial amount: NaN
has part: Q9UHI5
is: SBO:0000297
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_b1413c9d_70f1_495b_8b71_2de00e8f1f30
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6561
is: Q9BZW2
type: Species
initial amount: NaN
has only substance units: false
name: SLC13A1
is: SBO:0000252

metaR OCDCAtr
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110058#_bcc4e41f_a366_4afe_b140_63652a65e355
initial amount: NaN
is encoded by: hsa:374907
type: Species
has only substance units: false
initial concentration: NaN
is: Q7Z7M8
is: SBO:0000252
constant: false
name: B3GNT8
boundary condition: true

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM 5tedtricoa m
name: 5,8,11-tetradecatrienoylcoa
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
is: HMDB02288
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false

metaM ddcacoa x
is: CHEBI:57375
boundary condition: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: HMDB03571
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)
has only substance units: false
type: Species
initial amount: NaN
is: C01832

metaM HC02187 e
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:28774
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_568a5370_f24e_41b5_bb77_d7eb167ee08d
has only substance units: false
initial concentration: NaN
is: Q93099
is encoded by: hsa:3081
constant: false
type: Species
name: HGD
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR ACHtn
type: Reaction
product: MODEL1310110058#
name: Acetylcholin transport, nuclear trhough pores
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_f55044f6_877a_4434_8c7d_088fde1d57df
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:T83654
boundary condition: true
name: _T83654_1_e
is: SBO:0000252
constant: false
has only substance units: false

metaM asn L c
initial concentration: 1.0
name: L-asparagine
is: CHEBI:17196
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
has only substance units: false
initial amount: NaN
constant: false

metaR CHOLPtg
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
name: choline phosphate intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110058#
fast: false

metaM phytcoa x
constant: false
name: phytanoyl-CoA(4-)
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: CHEBI:57391
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01359
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_4a95106a_27b3_4e6a_95cd_e309e413c2ee
name: AMT
type: Species
is: P48728
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:275
is: SBO:0000252

metaM HC01401 m
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:27668
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_883b823b_ca23_4b6f_88d5_f01601e400a8
is encoded by: hsa:2819
initial concentration: NaN
name: GPD1
is: F8W1L5
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR RE3218C
product: MODEL1310110058#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.6.2
name: RE3218
fast: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
reversible: true
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_689f1b4e_b162_440d_b47c_9b2697a688bd
is: SBO:0000252
is: P17516
constant: false
type: Species
is encoded by: hsa:1109
name: AKR1C4
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_1c57e349_4073_4ba9_91d0_30f5d9277681
name: CLYBL
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:171425
constant: false
type: Species
initial amount: NaN

metaM glyc R c
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate
is: CHEBI:16659
is: HMDB00139
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_328cb418_8409_4c7c_85f9_fad68a86935b
type: Species
is encoded by: hsa:93034
is: B3KUK6
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: NT5C1B
is: SBO:0000252

metaM 4nph c
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57917
constant: false
name: 4-nitrophenolate
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01232

metaR ACNACNGALGBSIDEte
type: Reaction
product: MODEL1310110058#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110058#
is: SBO:0000185
name: acnacngalgbside hs transport
is described by: ECO:0000000
kinetic law: MODEL1310110058#

metaR r0085
type: Reaction
reversible: false
product: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.42

metaR TRPt
is described by: ECO:0000269
modifier: MODEL1310110058#
reversible: true
product: MODEL1310110058#
type: Reaction
fast: false
is: SBO:0000185
name: L-tryptophan transport
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_3a87d990_8d0a_41a5_aa35_dde2c770021e
has only substance units: false
is encoded by: hsa:4129
name: MAOB
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: P27338

metaM ile L e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17191
boundary condition: false
type: Species
constant: false
is: HMDB00172
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN

metaR LNLCCPT1
modifier: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110058#
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase
reversible: false
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110058#

metaR FAOXC165C164m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b72db3c0_89f2_4c96_9c96_0bb519220112
is encoded by: hsa:22305
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: _22305_2_c

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR CHSTEROLtrc
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
product: MODEL1310110058#
is described by: ECO:0000134
kinetic law: MODEL1310110058#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
name: transport of cholesterol into the cytosol

metaR r0940
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: Free diffusion
fast: false
reversible: true
is: SBO:0000185

metaM h2o c
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
name: H2O
constant: false
notes: FORMULA: H2O CHARGE: 0
is: HMDB02111
initial concentration: 1.0
is: CHEBI:3303
is: C00001

metaM itp n
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
is: HMDB00189
name: ITP(3-)
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_467f624f_73c1_4e89_af1f_cd690b7f0696
name: AK4
is: P27144
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:205
initial concentration: NaN
has only substance units: false

metaM dttp m
is: HMDB01342
type: Species
name: dTTP
is: SBO:0000247
is: C00459
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:37568
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
initial amount: NaN

metaR AG13T4g
modifier: MODEL1310110058#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR CSNAT2m
is described by: ECO:0000000
name: carnitine O-aceyltransferase, mitochondrial
fast: false
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
modifier: MODEL1310110058#

metaM h2o g
constant: false
initial amount: NaN
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
has only substance units: false
boundary condition: false
is: CHEBI:15377
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR r0086
type: Reaction
modifier: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.3
kinetic law: MODEL1310110058#
fast: false

metaR ATP2ter
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
name: AMP/ATP transporter, endoplasmic reticulum
type: Reaction

metaM dcacoa x
is: HMDB06404
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: CHEBI:61430
type: Species
is: SBO:0000247
constant: false
boundary condition: false
name: Decanoyl-CoA (n-C10:0CoA)
is: C05274

metaR VITD3t2
fast: false
type: Reaction
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
name: Vitamin D3 uptake

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM cala c
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:11892
constant: false
initial concentration: 1.0
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
name: N-carbamoyl-beta-alaninate
is: HMDB00026
initial amount: NaN
has only substance units: false

metaM HC02187 c
type: Species
name: reverse-triiodthyronine
initial amount: NaN
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
boundary condition: false
is: CHEBI:28774
is: SBO:0000247
initial concentration: 1.0

metaM cspg e l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
initial concentration: 1.0
type: Species
is: CHEBI:36005
boundary condition: false
constant: false
is: HMDB02183
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR MAL Ltx
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
reversible: true
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110058#
fast: false
type: Reaction
product: MODEL1310110058#
name: Transport reaction for malate

http://identifiers.org/biomodels.db/MODEL1310110058#_7e05451d_121b_4b5f_9768_6b682309a88f
is: SBO:0000252
constant: false
is: Q9Y619
is encoded by: hsa:10166
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC25A15
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_16dd7b95_f8be_4cef_bebb_0e6fef17428f
type: Species
initial amount: NaN
is: Q96KH8
boundary condition: true
is encoded by: hsa:6530
name: SLC6A2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaM asn L e
is: CHEBI:17196
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: L-asparagine
type: Species
is: HMDB00168
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial amount: NaN
constant: false
has only substance units: false

metaM atp m
constant: false
initial concentration: 1.0
is: CHEBI:57299
is: HMDB00538
is: C00002
name: ATP(4-)
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_fae99abf_4493_4cfc_8d6a_aeb722e0f804
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8574
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: AKR7A2
is: O43488

metaM co c
is: SBO:0000247
has only substance units: false
constant: false
name: carbon monoxide
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: HMDB01361
is: CHEBI:17245
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR ACHEe
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110058#
type: Reaction
name: Acetylcholinesterase
product: MODEL1310110058#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.1.7
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ

metaR LNLCCPT2
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
product: MODEL1310110058#
fast: false
type: Reaction
name: carnitine transferase

http://identifiers.org/biomodels.db/MODEL1310110058#_b44f5af2_c516_4188_a66c_b705cb35528a
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: P15309
is encoded by: hsa:55
initial concentration: NaN
name: ACPP

metaR r2509
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
name: Utilized transport
reactant: MODEL1310110058#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110058#

metaM dttp n
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
is: C00459
name: dTTP
is: CHEBI:37568
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01342
initial amount: NaN
has only substance units: false
constant: false

metaM ksi pre19 g
is: HMDB00175
initial amount: NaN
is: CHEBI:58053
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
constant: false
initial concentration: 1.0
is: C00130
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 19

http://identifiers.org/biomodels.db/MODEL1310110058#_f81a0404_0796_494d_9feb_89ff8be5b7a5
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC26A1
boundary condition: true
type: Species
constant: false
is encoded by: hsa:10861

metaR C6DCc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaM c4crn x
type: Species
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
constant: false
name: butyryl carnitine
is: SBO:0000247
is: HMDB02013
initial amount: NaN
notes: FORMULA: C11H21NO4 CHARGE: 0
boundary condition: false
is: C02862

metaR ACNACNGALGBSIDEtg
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: acnacngalgbside hs intracellular transport
reactant: MODEL1310110058#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
type: Reaction

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
is: CHEBI:57917
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: 4-nitrophenolate
is: SBO:0000247
is: HMDB01232
type: Species

metaM h2o e
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB02111
name: H2O
is: CHEBI:15377
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
is: SBO:0000247

metaM ile L c
is: SBO:0000247
is: CHEBI:17191
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
boundary condition: false

metaM atp n
is: HMDB00538
name: ATP(3-)
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57299
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
constant: false
boundary condition: false

metaR PI345P3P
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.67
reactant: MODEL1310110058#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
product: MODEL1310110058#
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaM acgam c
type: Species
boundary condition: false
name: N-acetyl-D-glucosamine
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
is: HMDB00215
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_ade4c900_48a6_4e07_a890_7a63b282cbfc
initial concentration: NaN
type: Species
name: DGKQ
constant: false
initial amount: NaN
is encoded by: hsa:1609
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P52824

metaR GLCter
name: glucose transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true
fast: false

metaR FAOXC241C221x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

metaR G3PD1
modifier: MODEL1310110058#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
reactant: MODEL1310110058#
name: glycerol-3-phosphate dehydrogenase (NAD)
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.8
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2

metaR Asn X Ser Thrtr
kinetic law: MODEL1310110058#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
reversible: true
name: Asn-X-Ser/Thr transport (from ER to lysosome)

metaR r0779
is: SBO:0000176
reversible: false
product: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
modifier: MODEL1310110058#
fast: false

metaR RE3627M
kinetic law: MODEL1310110058#
product: MODEL1310110058#
name: RE3627
is: SBO:0000176
reversible: true
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_fd2901de_9c32_464d_818e_3993f45d422c
type: Species
boundary condition: true
has only substance units: false
name: PLCD3
is: Q8N3E9
is encoded by: hsa:113026
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaM 3mgcoa m
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
name: trans-3-methylglutaconyl-CoA(5-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:57346
initial concentration: 1.0
is: HMDB01057
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_98b89a3a_e3c1_42c0_a0bb_f10d68b065ce
boundary condition: true
is: SBO:0000297
is encoded by: hsa:4712
constant: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q5VYT2
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4731

metaM val L c
name: L-valine
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
is: HMDB00883
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

metaM ksi pre5 g
is: SBO:0000247
is: CHEBI:28067
type: Species
notes: FORMULA: C101H164N7O75SX CHARGE: -2
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 5
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_bbe40239_8fe2_42e2_a835_e2946ac59f54
is encoded by: hsa:8875
constant: false
type: Species
has only substance units: false
is: A8K7W0
name: VNN2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM ddeccrn c
type: Species
constant: false
has only substance units: false
name: lauroyl carnitine
notes: FORMULA: C19H37NO4 CHARGE: 0
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB02250
boundary condition: false

metaR FUMTSULtm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110058#
name: Fumarate:thiosulfate antiport, mitochondrial
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true
is: SBO:0000185
type: Reaction
fast: false

metaR r0345
reactant: MODEL1310110058#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
modifier: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_b1e2862b_c035_447f_9bc6_08e534ca8814
name: ND4L
initial concentration: NaN
is: Q7GXZ4
type: Species
is encoded by: hsa:4539
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_5fec86e2_6d51_493d_bd2f_d3e687d76682
is encoded by: hsa:4726
boundary condition: true
name: NDUFS6
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: Q6IBC4
is: SBO:0000252
initial concentration: NaN

metaR PDE4
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.17
is version of: http://identifiers.org/ec-code/3.1.4.35
modifier: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
fast: false
type: Reaction
reversible: false
name: 3',5'-cyclic-nucleotide phosphodiesterase
product: MODEL1310110058#

metaM pheacgln c
boundary condition: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: CHEBI:58310
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
has only substance units: false
type: Species
is: HMDB06344

http://identifiers.org/biomodels.db/MODEL1310110058#_9bbe109b_e376_490c_9e14_a131d6edf582
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PTGS2
is encoded by: hsa:5743
is: SBO:0000252
initial amount: NaN
is: P35354
type: Species

metaM xan x
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00292
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: CHEBI:17712
is: C00385
name: Xanthine
constant: false

metaR r1589
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000185
product: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaM g3m8masn r
is: C05873
has only substance units: false
constant: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_75b50d16_e764_4ec6_8baa_2972b65fc46b
is: P30825
constant: false
is encoded by: hsa:6541
type: Species
has only substance units: false
initial amount: NaN
name: SLC7A1
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR S23T2g
reversible: false
reactant: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110058#
is: SBO:0000176
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_c377c155_f7ed_4515_ad63_a7888b7ee0d5
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: ACAA2
type: Species
initial concentration: NaN
is encoded by: hsa:10449
has only substance units: false
is: P42765

metaR ABUTt2r
modifier: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
is described by: ECO:0000304
name: 4-aminobutyrate reversible transport in via proton symport
fast: false
reactant: MODEL1310110058#
type: Reaction

metaM val L e
has only substance units: false
name: L-valine
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
is: CHEBI:16414
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaM pail45p hs c
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
constant: false
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_beccd871_6ac9_48be_9f85_a3262fb70b60
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9334
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: B4GALT5
is: O43286
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_a5685d00_d969_4d98_8c14_6c65199c9c00
boundary condition: true
constant: false
has only substance units: false
name: AMPD2
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:271
is: SBO:0000252
is: E9PNG0

http://identifiers.org/biomodels.db/MODEL1310110058#_7a94e70f_f5f3_4bc4_b686_0344b7a7c312
constant: false
type: Species
is: O75438
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: NDUFB1
is encoded by: hsa:4707

metaR FAOXC5C5DCc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaR ENGASE2ly
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
is: SBO:0000176
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: false

metaR ADK1m
fast: false
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
name: adenylate kinase, mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
modifier: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#

metaM fprica c
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
initial concentration: 1.0
is: C04734
is: HMDB01439
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:58467
has only substance units: false

metaM 2mpdhl m
name: S-(2-Methylpropanoyl)-dihydrolipoamide
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:17577
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

metaR CSNAT2x
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110058#
is described by: ECO:0000269

metaM 3php c
has only substance units: false
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01024
initial amount: NaN
name: 3-phosphonatooxypyruvate(3-)
is: CHEBI:18110
is: SBO:0000247
constant: false

metaM HC01603 c
is: CHEBI:57454
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: 10-Formyltetrahydrofolate
type: Species
is: C00234
is: SBO:0000247

metaM 2mop c
name: 2-methyl-3-oxopropanoate
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
is: HMDB01172
has only substance units: false
is: CHEBI:57700
constant: false

metaR SQLEr
is described by: ECO:0000134
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.132
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
name: Squalene epoxidase, endoplasmic reticular (NADP)

http://identifiers.org/biomodels.db/MODEL1310110058#_2fac1e33_4ab4_4bfe_849f_f3024cceb3b4
has only substance units: false
is encoded by: hsa:10327
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: P14550
initial amount: NaN
name: AKR1A1

metaM 3ivcoa m
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/11966188
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
is: C05998
name: 3-hydroxyisovalerylcoa
constant: false
boundary condition: false
is: HMDB06870
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_b34bbbfe_f783_4365_a3b8_b76015627105
type: Species
is encoded by: hsa:D87002
name: _D87002_1_e
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_86094b53_ac4f_4422_828e_7131c33a7938
is: Q9HAB8
is: SBO:0000252
constant: false
is encoded by: hsa:79717
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: PPCS
has only substance units: false

metaR RE0512M
fast: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110058#
name: RE0512
is: SBO:0000176

metaM gsn c
is: HMDB00133
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: C00387
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: SBO:0000247
name: Guanosine
initial amount: NaN
constant: false
is: CHEBI:16750

http://identifiers.org/biomodels.db/MODEL1310110058#_cac43115_dc1f_4128_8aaa_af74a49ef4ca
initial amount: NaN
is encoded by: hsa:5136
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: P54750
constant: false
name: PDE1A

metaM h2o m
initial amount: NaN
type: Species
name: H2O
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:15377
is: C00001
has only substance units: false
is: SBO:0000247
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR CO2tm
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is described by: ECO:0000000
name: CO2 transport (diffusion), mitochondrial

metaR r1586
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FAOXC225C204m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM cspg e e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00630
is: SBO:0000247
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: CHEBI:16040
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
type: Species
constant: false

metaM gcald c
name: glycolaldehyde
is: CHEBI:17071
initial concentration: 1.0
initial amount: NaN
is: HMDB03344
boundary condition: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: SBO:0000247
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_9b987edb_f48d_4ae2_81e6_38d63fd0bc51
type: Species
initial concentration: NaN
initial amount: NaN
name: ATP1A3:ATP1B1
boundary condition: true
has only substance units: false
has part: B7Z2T0
is encoded by: hsa:481
has part: A3KLL5
constant: false
is encoded by: hsa:478
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110058#_c7619d50_2d97_4b4f_ad96_6e23ed3147d5
initial concentration: NaN
constant: false
type: Species
is: Q9Y5B8
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:29922
boundary condition: true
name: NME7

http://identifiers.org/biomodels.db/MODEL1310110058#_92c108bb_7d1c_4b0c_ab8a_65b89b88107a
is encoded by: hsa:5305
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: PIP4K2A
is: P48426
initial amount: NaN
constant: false
boundary condition: true

metaM dttp c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: dTTP
is: SBO:0000247
type: Species
constant: false
is: C00459
has only substance units: false
is: CHEBI:37568
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459

metaM dcacoa m
is: C05274
type: Species
boundary condition: false
is: CHEBI:61430
is: HMDB06404
constant: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)

metaR XOL7AH2tm
type: Reaction
kinetic law: MODEL1310110058#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR r1585
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110058#
reversible: true
is: SBO:0000185
product: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110058#
is described by: ECO:0000000

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM h2o l
type: Species
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
has only substance units: false
constant: false
name: water
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:15377
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_5cce95dc_da89_4a3f_a8b2_fde870092ece
is: P49189
name: ALDH9A1
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:223
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaM ptdca e
has only substance units: false
is: SBO:0000247
name: pentadecanoate
boundary condition: false
is: HMDB00826
type: Species
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/22169126
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
constant: false

metaM CE2416 x
constant: false
name: (2R,6S,10S)-pristanate
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57923
boundary condition: false
type: Species
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_63e65605_e1e8_4377_b415_fdbaed0d264e
type: Species
is encoded by: hsa:191
initial amount: NaN
is: SBO:0000252
name: AHCY
has only substance units: false
initial concentration: NaN
is: B3KUN3
boundary condition: true
constant: false

metaR DESAT22 1p
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reversible: false

metaR RIBt
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110058#
name: ribose transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
product: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction

metaM odecoa c
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
initial amount: NaN
is: CHEBI:3793
boundary condition: false
initial concentration: 1.0
constant: false

metaM atp e
has only substance units: false
type: Species
is: HMDB00538
initial amount: NaN
is: C00002
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57299
name: ATP(4-)

metaM xoltetrol m
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:17278
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB01231
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol

http://identifiers.org/biomodels.db/MODEL1310110058#_610a3656_3b31_446e_8a6a_8c8e1ae08ba4
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6817
name: SULT1A1
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaM asn L m
is: HMDB00168
is: CHEBI:17196
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial amount: NaN
name: L-asparagine
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_8b2a4271_6dc1_4aca_872b_f7183ea9013b
is: SBO:0000252
boundary condition: true
is encoded by: hsa:65263
initial concentration: NaN
initial amount: NaN
name: PYCRL
has only substance units: false
is: Q53H96
constant: false
type: Species

metaR PDE1
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.17
product: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
is: SBO:0000176
name: 3',5'-cyclic-nucleotide phosphodiesterase
fast: false

metaR r1588
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110058#

metaR AKGMALtm
type: Reaction
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
reversible: true
name: alpha-ketoglutarate/malate transporter
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_8e4edac1_f075_42db_9ab8_69aadd516a83
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI761708
initial amount: NaN
name: _AI761708_1_m
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_0b13be93_822b_4170_8274_85c160c2b276
name: MGAT2
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4247
is: Q10469

http://identifiers.org/biomodels.db/MODEL1310110058#_47466d41_80cc_48a5_859c_76f25065aa91
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA526438
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: _AA526438_1_c
initial amount: NaN

metaR CERT2rt
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
product: MODEL1310110058#
fast: false
type: Reaction
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside

metaM dttp e
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
initial concentration: 1.0
has only substance units: false
name: dTTP(4-)
is: SBO:0000247
boundary condition: false
is: HMDB01342
constant: false
type: Species
initial amount: NaN

metaM HC01401 x
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial amount: NaN
constant: false
is: CHEBI:27668
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110058#_dfed96c5_32dd_4cfd_8454_95841907d1b7
initial amount: NaN
has only substance units: false
boundary condition: true
name: ACAD10
is: SBO:0000252
is: G3XAJ0
is encoded by: hsa:80724
type: Species
constant: false
initial concentration: NaN

metaR r0946
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r1587
kinetic law: MODEL1310110058#
fast: false
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaM ptdca c
name: pentadecanoate
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00826
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/22169126

metaR r0340
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
product: MODEL1310110058#
reversible: false
modifier: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110058#

metaM h2o n
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
is: SBO:0000247
has only substance units: false
name: water
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:15377
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_7dd3e176_b2b0_4b70_8c53_a06869d1360b
name: _H17063_1_m
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:H17063
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_6b98dee9_8ded_41a0_9fab_97e34dc55a1b
constant: false
has only substance units: false
type: Species
is: Q6YFQ2
name: COX6B2
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:125965
initial concentration: NaN

metaM hxcoa x
type: Species
has only substance units: false
is: HMDB13130
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_482d8ba4_ab6f_454a_94fc_f1d5f3fb2734
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: ST3GAL3
is encoded by: hsa:6487
is: Q5T4Y1
initial concentration: NaN
is: SBO:0000252

metaM glyc R m
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:16659
is: HMDB00139

metaM pheacgln e
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: CHEBI:58310
has only substance units: false
is: HMDB06344

http://identifiers.org/biomodels.db/MODEL1310110058#_9d43ddf7_c597_46e9_9110_7067487b981e
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: _U37519_1_e
is encoded by: hsa:U37519
is: SBO:0000252

metaR r1581
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0784
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110058#
fast: false
is: SBO:0000176
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
modifier: MODEL1310110058#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
kinetic law: MODEL1310110058#
type: Reaction

metaR OROTGLUt
product: MODEL1310110058#
reversible: true
type: Reaction
is described by: ECO:0000134
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#
name: OROTGLUt
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_76d392e5_79f2_4f7f_8360_b0d18f147ef3
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4695
has only substance units: false
name: NDUFA2
initial amount: NaN
is: O43678
is: SBO:0000252
initial concentration: NaN

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:27555
name: prostaglandin-c2
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM 3ivcoa c
is: http://identifiers.org/pubchem.compound/11966188
constant: false
is: HMDB06870
has only substance units: false
name: 3-hydroxyisovalerylcoa
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C05998
initial amount: NaN

metaM c3dc e
initial concentration: 1.0
has only substance units: false
is: HMDB02095
notes: FORMULA: C10H16NO6 CHARGE: -1
constant: false
is: SBO:0000247
name: malonyl carnitine
boundary condition: false
type: Species
initial amount: NaN

metaM ksi pre8 g
boundary condition: false
constant: false
type: Species
is: CHEBI:28067
initial concentration: 1.0
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 8
has only substance units: false
is: SBO:0000247

metaR TETTET6COAtx
name: fatty acid intracellular transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#

metaR r0908
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
product: MODEL1310110058#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110058#

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR BILIRUBtr
kinetic law: MODEL1310110058#
fast: false
name: lipid, flip-flop intracellular transport
reversible: true
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaM no c
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB03378
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
name: Nitric oxide
is: SBO:0000247
has only substance units: false
is: C00533

metaR LEULEULAPc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR r0783
fast: false
modifier: MODEL1310110058#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reversible: true
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110058#

metaM hdd2coa x
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB03945
boundary condition: false
name: (E)-hexadec-2-enoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:61526
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272

metaR RE1573M
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110058#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
reactant: MODEL1310110058#
type: Reaction
fast: false
product: MODEL1310110058#
name: RE1573
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is: SBO:0000176

metaR EX strch1 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

metaR UAGDP
reversible: false
kinetic law: MODEL1310110058#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.23
is: SBO:0000176
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
name: UDP-N-acetylglucosamine diphosphorylase
fast: false
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#

metaR DESAT18 4
is version of: http://identifiers.org/ec-code/1.14.19.1
modifier: MODEL1310110058#
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176

metaR CYTK5n
modifier: MODEL1310110058#
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reactant: MODEL1310110058#
is described by: ECO:0000269
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
type: Reaction
fast: false

metaM hpyr c
initial amount: NaN
name: 3-hydroxypyruvate
type: Species
initial concentration: 1.0
is: CHEBI:17180
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01352
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_1b44db01_fb8b_4597_a49d_5ea49ae3d2d7
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:HG2846-HT2983
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: _HG2846_HT2983_1_c

metaR DESAT22 2p
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: false

metaM prostgh2 e
name: prostaglandin H2(1-)
initial concentration: 1.0
is: CHEBI:57405
is: HMDB01381
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_93769285_6fbb_48c4_a13e_634d981d4ad9
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6120
name: RPE
initial amount: NaN
is: Q96AT9
has only substance units: false
boundary condition: true
constant: false

metaR IMPD
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.205
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
name: IMP dehydrogenase
modifier: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000134

metaM h2o r
is: C00001
is: SBO:0000247
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
is: CHEBI:15377
type: Species
name: H2O
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_3ad4b757_9938_4ddf_8255_220be4e9e009
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:5147
has part: P18545
is: SBO:0000297
boundary condition: true
has part: O43924
initial amount: NaN
is encoded by: hsa:5148
has only substance units: false
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B

metaR DRPA
fast: false
kinetic law: MODEL1310110058#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110058#
name: deoxyribose-phosphate aldolase
reactant: MODEL1310110058#
is: SBO:0000176

metaM HC02207 c
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
type: Species
is: CHEBI:27555
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: prostaglandin-c2

metaR r1583
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110058#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_c0c150b7_cd44_44af_aa97_9e84380f2426
is: Q9NRZ7
name: AGPAT3
boundary condition: true
initial amount: NaN
is encoded by: hsa:56894
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_8705c847_20e9_44cc_8b5b_0d5b6269d38b
type: Species
is: O60312
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ATP10A
constant: false
is encoded by: hsa:57194
has only substance units: false
boundary condition: true

metaM itp c
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57614
boundary condition: false
is: HMDB00189

http://identifiers.org/biomodels.db/MODEL1310110058#_8792a483_2c3d_4e33_8ac1_d369d1d6e41a
name: ABCB4
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5244
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR LNLCt
product: MODEL1310110058#
type: Reaction
name: Linoleic acid (n-C18:2) transport in via diffusion
kinetic law: MODEL1310110058#
is: SBO:0000185
reversible: true
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is described by: ECO:0000000

metaR r1888
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
fast: false
reversible: false

metaR UDPGLCter
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
fast: false
type: Reaction
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000

metaR IMPC
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
name: IMP cyclohydrolase
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.3
fast: false
modifier: MODEL1310110058#

metaR SERGLNexR
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000304
fast: false
reversible: true
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
name: L-Serine/Glutamine reversible exchange
modifier: MODEL1310110058#

metaM HC01459 x
constant: false
is: CHEBI:27458
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
is: SBO:0000247
has only substance units: false
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA

metaM acnam n
constant: false
is: CHEBI:35418
is: HMDB00230
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0
initial amount: NaN
name: N-acetylneuraminate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_0e9a03cb_c724_410f_9199_75dd0ac7bccc
is: B4E097
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: GALT
is encoded by: hsa:2592
initial amount: NaN

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

metaR DOLPMT L
name: Dolichyl-phosphate D-mannosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.83
reversible: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
kinetic law: MODEL1310110058#
is: SBO:0000176
fast: false
product: MODEL1310110058#

metaM pmtcoa r
type: Species
is: C00154
constant: false
is: HMDB01338
has only substance units: false
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
initial amount: NaN
boundary condition: false
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: SBO:0000247

metaM ocdca e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:25629
type: Species
is: HMDB00827
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
name: octadecanoate (n-C18:0)

metaR DESAT18 6
is described by: ECO:0000269
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000176
reversible: false

metaR r1584
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM m8masn r
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
type: Species
initial amount: NaN
is: C05876
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C70H117N2O55X CHARGE: 0

metaR FAOXC226
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110058#
type: Reaction
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_3a3035c3_c6c5_4f8d_91dc_1b2ec06dc94f
is: E7EPT3
name: ALDH7A1
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:501

metaM ksi pre16 g
has only substance units: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: HMDB00175
is: CHEBI:58053
is: C00130
name: keratan sulfate I biosynthesis, precursor 16
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

metaM c3dc c
has only substance units: false
is: HMDB02095
initial concentration: 1.0
notes: FORMULA: C10H16NO6 CHARGE: -1
name: malonyl carnitine
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_74f6b425_a32f_4a68_a510_7002ba0b5384
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AI656480
has only substance units: false
initial amount: NaN
name: _AI656480_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_4e30df3f_2aad_4cef_864c_ae355e2e4612
name: ADH6
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: P28332
initial concentration: NaN
is encoded by: hsa:130

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM dnad c
is: CHEBI:18304
initial amount: NaN
is: HMDB01179
is: C00857
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
has only substance units: false
boundary condition: false
name: Deamino-NAD+
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_e23ea4d6_c563_40cc_819b_28c1714c1881
name: DGKH
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:160851
type: Species
is: A8K0I1
is: SBO:0000252
initial concentration: NaN

metaM gd3 hs g
constant: false
name: GD3
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
is: CHEBI:28424

http://identifiers.org/biomodels.db/MODEL1310110058#_99407f8b_1390_402b_a715_b22693b535f4
name: SLC6A12
type: Species
has only substance units: false
is encoded by: hsa:6539
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: P48065
initial concentration: NaN

metaM ha pre1 e
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
constant: false
is: SBO:0000247
name: hyaluronan biosynthesis, precursor 1
is: CHEBI:16126
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_e46c37a5_516b_4e65_aef1_ec95d0c21565
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: CYP8B1
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1582
is: Q9UNU6

metaR NDPK1m
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
is described by: ECO:0000254

metaM sphmyln hs g
constant: false
initial concentration: 1.0
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
boundary condition: false
is: CHEBI:58216
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247

metaR GUAt
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reactant: MODEL1310110058#
name: Guanine transport
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_8297b102_5eec_445e_9d95_ca95cc6a3eae
is: E7ET32
boundary condition: true
has only substance units: false
is encoded by: hsa:2592
initial amount: NaN
type: Species
name: GALT
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_287233bd_82f3_4407_89d0_df01708483de
has only substance units: false
is: SBO:0000252
name: CMA1
boundary condition: true
is encoded by: hsa:1215
is: Q4FEB3
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaM malcoa c
is: C00083
is: HMDB01175
boundary condition: false
is: CHEBI:57384
name: Malonyl-CoA
initial amount: NaN
constant: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r0788
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.13.15
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
modifier: MODEL1310110058#
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_fc2ea499_5514_4c6b_a702_eb29dd9473dc
has only substance units: false
is encoded by: hsa:28976
type: Species
initial amount: NaN
name: ACAD9
is: Q9H845
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_3fb3f931_3eb4_49fb_b732_309d29cab348
type: Species
has only substance units: false
constant: false
name: SLC1A5
is encoded by: hsa:6510
is: Q15758
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_5bcab73a_be4b_4e0c_b830_6726a33b256f
boundary condition: true
initial amount: NaN
name: PLA2G2E
is: Q9NZK7
initial concentration: NaN
is encoded by: hsa:30814
type: Species
is: SBO:0000252
constant: false
has only substance units: false

metaR ACCOAC
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_72ac39e1_546c_4e11_b9ff_d0cc1348f162
is encoded by: hsa:477
constant: false
name: ATP1A2
is: P50993
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM bilirub r
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57977
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054

metaM ocdca c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: CHEBI:25629
constant: false
initial amount: NaN
name: stearate
initial concentration: 1.0
is: HMDB00827
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_4c41aef4_dd06_4811_a165_5c12ac3899a7
is encoded by: hsa:2184
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: P16930
name: FAH

http://identifiers.org/biomodels.db/MODEL1310110058#_d59b6a21_43f7_43b5_b1a8_da045ecb580c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q8NCG5
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:10164
name: CHST4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_0ebb603a_5213_454b_a202_f95f4583eb6d
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5152
name: PDE9A
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_804ba59c_23c0_4723_92e4_4afb7916f4eb
is: SBO:0000252
name: GGCT
constant: false
type: Species
initial concentration: NaN
is: B8ZZR8
is encoded by: hsa:79017
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r0787
modifier: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110058#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.1

metaM 1pyr5c c
is: C03912
is: HMDB01301
is: CHEBI:15893
name: 1-Pyrroline-5-carboxylate
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial concentration: 1.0

metaM fe3 c
type: Species
name: Fe3+
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: Fe CHARGE: 3
constant: false
initial concentration: 1.0
is: HMDB12943
initial amount: NaN

metaR DM dttp m
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaM acnacngalgbside hs g
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:3338
initial concentration: 1.0
is: HMDB00223
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
constant: false
is: C00036
initial amount: NaN
name: disialyl galactosylgloboside

metaR FAOXC184m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_97d9efce_7475_4c18_9302_912a5352d3fd
type: Species
is: SBO:0000252
is encoded by: hsa:6675
initial amount: NaN
constant: false
initial concentration: NaN
name: UAP1
boundary condition: true
has only substance units: false
is: Q16222

metaR MAL Lte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
name: Transport of L-malate
reversible: true
type: Reaction
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR RE1709C
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000176
name: RE1709
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_eeaaab3d_94e9_4baa_91f6_f57fb0a834f1
is: P18283
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2877
name: GPX2
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaM csn c
is: HMDB00630
constant: false
initial amount: NaN
is: CHEBI:16040
name: cytosine
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_b603911c_5a61_450c_a3ad_2791d326dbe3
has only substance units: false
name: ATP1A1
constant: false
boundary condition: true
is: SBO:0000252
is: B7Z3U6
initial amount: NaN
is encoded by: hsa:476
type: Species
initial concentration: NaN

metaM pmtcoa x
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_a480ec74_7db8_49ff_9b1c_c9f3da0a4c1c
has only substance units: false
constant: false
type: Species
is: Q5DSZ6
is: SBO:0000252
name: UGT1A8
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:54576
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_28131bc4_18a4_4cca_94a9_e7f7ef0dc242
is: B7Z2T0
name: ATP1A3
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:478
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_05a08894_8a8c_4116_b245_8717237f4206
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI926493
name: _AI926493_1_c
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_353659be_d15c_4b50_9d38_8e0bc4eadce1
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2650
is: SBO:0000252
name: GCNT1
type: Species
constant: false
is: Q02742
initial concentration: NaN

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM ddeccrn e
notes: FORMULA: C19H37NO4 CHARGE: 0
type: Species
has only substance units: false
is: HMDB02250
constant: false
name: lauroyl carnitine
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM ksi pre10 g
initial amount: NaN
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
constant: false
is: SBO:0000247
is: HMDB00175
is: C00130
type: Species
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 10
is: CHEBI:58053
has only substance units: false

metaR r1580
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR r0789
modifier: MODEL1310110058#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
reversible: true
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.13.15

metaM prostgh2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: prostaglandin H2(1-)
is: CHEBI:57405
is: HMDB01381

metaM acnacngalgbside hs e
is: CHEBI:3338
type: Species
is: HMDB00223
initial amount: NaN
name: disialyl galactosylgloboside
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: C00036
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: SBO:0000247

metaR TIGCRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaR SUCCtp
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110058#
is: SBO:0000185
name: succinate transporter, peroxisome
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000000
type: Reaction

metaM so3 c
is: SBO:0000247
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
constant: false
is: C00094
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17137
type: Species
name: Sulfite

metaM xol7ah2al m
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
has only substance units: false
is: HMDB06894
boundary condition: false
constant: false
type: Species
is: CHEBI:27428

metaR ME2m
is described by: ECO:0000000
fast: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.40
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: malic enzyme (NADP), mitochondrial
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false

metaM dhbpt c
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: HMDB00038
type: Species
is: SBO:0000247
name: 6,7-dihydrobiopterin
boundary condition: false
has only substance units: false
is: CHEBI:20680
constant: false
initial concentration: 1.0

metaR PVD3
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
product: MODEL1310110058#
reversible: true
name: Previtamin D3 formation

metaM fe3 e
constant: false
is: HMDB12943
boundary condition: false
has only substance units: false
name: Fe3+
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: CHEBI:29034
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r0909
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110058#
fast: false
reversible: true
product: MODEL1310110058#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:

metaR 6HTSTSTERONEtr
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, inactivated testosterone transport to get out of cell NJ
kinetic law: MODEL1310110058#
type: Reaction
is: SBO:0000185
name: hydroxylated testosterone transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_046b854b_c4b4_4f3b_bddb_33823aab1872
is encoded by: hsa:521
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P56385
boundary condition: true
name: ATP5I
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_54a00356_b8ee_48b7_8297_ad382d8e563b
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: SLC4A5
is encoded by: hsa:57835
initial concentration: NaN
type: Species

metaM h2o x
is: CHEBI:15377
name: H2O
type: Species
is: C00001
is: HMDB02111
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
boundary condition: false

metaR r0627
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
kinetic law: MODEL1310110058#
fast: false
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
reversible: true
product: MODEL1310110058#
is: SBO:0000176

metaM csn e
has only substance units: false
boundary condition: false
is: CHEBI:16040
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: HMDB00630
initial concentration: 1.0
name: cytosine
type: Species

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR r1464
reversible: true
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#

metaM odecoa m
type: Species
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: HMDB01322
name: Octadecenoyl-CoA (n-C18:1CoA)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57387
has only substance units: false

metaR r2519
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
reversible: true
name: Utilized transport
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#

metaM acnacngalgbside hs c
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00223
has only substance units: false
is: C00036
boundary condition: false
is: CHEBI:3338
type: Species
initial amount: NaN
name: disialyl galactosylgloboside

metaM phytcoa c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: CHEBI:57391
is: HMDB01359
name: phytanoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110058#_ea1f4c5a_e033_430e_ae53_a71543a2a19d
has part: P07327
type: Species
constant: false
name: ADH1A:ADH1B
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:124
boundary condition: true
initial amount: NaN
has only substance units: false

metaM adpcoa c
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB04047
is: C14143
constant: false
is: SBO:0000247
name: adipoylcoa
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110058#_9deabfa2_9e7a_4265_a99e_b1d587a7f626
name: GALT
is encoded by: hsa:2592
is: B2RAT6
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaM rib D e
type: Species
has only substance units: false
is: HMDB00283
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false
name: D-ribose

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR TYROXDAc
modifier: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
is version of: http://identifiers.org/ec-code/1.4.3.4
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110058#
type: Reaction

metaR S6T1g
is: SBO:0000176
product: MODEL1310110058#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false

metaR r2518
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reversible: true
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
is described by: ECO:0000000

metaR r0629
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.22
is version of: http://identifiers.org/ec-code/3.1.4.1
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000176
reversible: true
product: MODEL1310110058#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:

metaM thr L e
name: L-threonine
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
constant: false
has only substance units: false
is: HMDB00167
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_a106455b_ff44_41cd_90d1_0f53752c4226
name: ESPN
constant: false
is encoded by: hsa:83715
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: B1AK53
boundary condition: true
is: SBO:0000252

metaM c8dc c
name: suberyl carnitine
is: SBO:0000247
initial concentration: 1.0
is: C02838
boundary condition: false
is: HMDB00791
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C15H26NO6 CHARGE: -1

metaM prpp e
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:58017
constant: false
type: Species
is: HMDB00280
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false

metaR 3MOPte
is described by: ECO:0000134
fast: false
product: MODEL1310110058#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110058#
type: Reaction
name: Transport of 3-methyl-2-oxopentanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110058#

metaR r1466
name: EC:2.3.1.86
is: SBO:0000176
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110058#
reversible: true
product: MODEL1310110058#
fast: false

metaR RE0383C
modifier: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110058#
name: RE0383
reversible: true
fast: false
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction

metaR C51CPT1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR DOLPH Ler
fast: false
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
reactant: MODEL1310110058#
is: SBO:0000176
reversible: false
name: Dolichol-phosphate phosphohydrolase, human (liver)

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR NDPK1n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
fast: false
product: MODEL1310110058#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
kinetic law: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction

metaM HC01410 m
is: CHEBI:28706
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: (2E)-Hexenoyl-CoA
boundary condition: false
has only substance units: false

metaR r1467
name: Postulated transport reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_35e18777_d598_4d6b_b5f9_f82d6bb7903c
is: E7ET30
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: AK3
is encoded by: hsa:50808
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_9af11817_ae80_47d7_852d_16a53f41bc67
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:3906
initial amount: NaN
boundary condition: true
name: LALBA
is: P00709

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR RE1447N
type: Reaction
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: RE1447

http://identifiers.org/biomodels.db/MODEL1310110058#_dbcc9ed0_9ea5_4bf7_b6b8_96de57550d97
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:100287639
initial concentration: NaN
name: _100287639_1_c
constant: false
boundary condition: true

metaR CBR2
reversible: false
fast: false
modifier: MODEL1310110058#
name: Carbonyl reductase [NADPH] 1
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.189
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
type: Reaction
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR DINt
reversible: true
fast: false
reactant: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110058#
name: deoxyinosine transport via diffusion
is: SBO:0000185

metaR RE1709N
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
modifier: MODEL1310110058#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE1709
is described by: ECO:0000000
product: MODEL1310110058#

metaR r2516
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_f66d4151_c1e1_4039_aa93_63805af22389
has only substance units: false
is: SBO:0000252
is: Q99643
type: Species
name: SDHC
is encoded by: hsa:6391
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaM itp e
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
name: ITP(3-)
initial amount: NaN
type: Species
is: HMDB00189
boundary condition: false
is: SBO:0000247
is: CHEBI:57614
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_be329417_d3f1_4c88_9895_28f2f00ad37f
constant: false
has only substance units: false
name: TMEM91
is encoded by: hsa:641649
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: C9JZ62

http://identifiers.org/biomodels.db/MODEL1310110058#_94f772b7_1fb1_4cfe_81c1_81d606cb0801
boundary condition: true
is encoded by: hsa:AI024818
initial amount: NaN
type: Species
has only substance units: false
name: _AI024818_1_c
is: SBO:0000252
constant: false
initial concentration: NaN

metaM pmtcoa m
is: HMDB01338
boundary condition: false
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:57379
is: C00154
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial amount: NaN
type: Species
constant: false

metaM prpp c
is: SBO:0000247
is: C00119
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
constant: false
has only substance units: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate
type: Species
is: HMDB00280

metaR r0780
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
product: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
type: Reaction

metaM retinal c
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: CHEBI:15035
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01358
name: retinal

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR RE3243R
fast: false
modifier: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
reactant: MODEL1310110058#
name: RE3243

http://identifiers.org/biomodels.db/MODEL1310110058#_515cd363_c346_4c8b_a4d2_9dea93519eae
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:100
initial concentration: NaN
is: P00813
boundary condition: true
constant: false
name: ADA
type: Species

metaR DOLGLCP Lter
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#

metaM pail45p hs n
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
is: CHEBI:28910
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_3223bde3_eca0_40ad_8bbc_7e1ce245be4d
is: Q02318
type: Species
constant: false
is encoded by: hsa:1593
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: CYP27A1
initial concentration: NaN
boundary condition: true

metaR r0494
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
fast: false
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_39177d9e_7b66_4c8c_8d7c_18566d4dde42
type: Species
is encoded by: hsa:NM 001929
initial amount: NaN
name: _NM_001929_1_c
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM odecoa r
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
name: oleoyl-CoA(4-)
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57387
is: HMDB01322
initial concentration: 1.0
initial amount: NaN

metaM 2obut m
is: HMDB00005
boundary condition: false
is: SBO:0000247
type: Species
name: 2-oxobutanoate
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16763

metaM atp x
type: Species
is: HMDB00538
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: ATP(4-)
boundary condition: false
is: C00002
initial concentration: 1.0
is: CHEBI:57299

metaM no e
has only substance units: false
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16480
type: Species
initial amount: NaN
is: HMDB03378
is: C00533

http://identifiers.org/biomodels.db/MODEL1310110058#_b138fd5c_e8e7_4b68_8ed1_fec4f242aa35
is: P39877
constant: false
name: PLA2G5
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5322
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_52c42726_4016_460f_b362_9deccee28edd
is encoded by: hsa:6241
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is: P31350
name: RRM2
constant: false

metaR SERALANaEx
kinetic law: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: false
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR NDP7er
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
type: Reaction
reversible: false
product: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_75a8ee42_6d7f_4fb7_a91a_fd76ab391b4e
has only substance units: false
constant: false
is: SBO:0000252
is: Q96NT5
type: Species
boundary condition: true
is encoded by: hsa:113235
initial amount: NaN
initial concentration: NaN
name: SLC46A1

metaR r2514
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
name: Utilized transport
reversible: true
fast: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_fc0eee4c_ffac_4e55_8973_e967a3b957ba
name: GBA
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2629
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR r0782
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
is: SBO:0000176
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
fast: false
reversible: false
reactant: MODEL1310110058#

metaR 3MOPt2im
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110058#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
reactant: MODEL1310110058#
fast: false

metaR RE1447M
is described by: ECO:0000000
reactant: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
name: RE1447
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110058#

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM dd2coa c
has only substance units: false
name: trans-Dodec-2-enoyl-CoA
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB03712
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
constant: false

metaR GLUt7l
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
reversible: false
name: Glutamate transport, lysosomal

metaR PECTCHLe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of pectins with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

MODEL1310110058
reaction: metaR EX CE2839 LPAREN e RPAREN
reaction: metaR ACOAD1fm
reaction: metaR r1940
species: metaM clpn hs c
species: metaM so4 e
reaction: metaR r0494
reaction: metaR r1650
reaction: metaR ASCBOX
reaction: metaR PPItm
reaction: metaR MMEm
reaction: metaR GUAt
species: metaM gdp c
species: metaM L2aadp c
reaction: metaR r0196
reaction: metaR ECOAH1m
reaction: metaR RE1836X
reaction: metaR 6HTSTSTERONEte
reaction: metaR XAO2x
reaction: metaR FACOAL245 1
reaction: metaR r2359
species: metaM arg L e
reaction: metaR EX arachcoa LPAREN e RPAREN
species: metaM c51crn e
reaction: metaR RE1447N
species: metaM 4ppcys c
species: metaM 34hpp e
species: metaM dudp n
species: metaM ru5p D c
reaction: metaR NDPK3m
reaction: metaR HACD1m
reaction: metaR ACGAM6PSi
reaction: metaR PPItx
reaction: metaR CYSASNNaEx
reaction: metaR PYRt2m
species: metaM cit e
species: metaM pheme c
reaction: metaR D LACt2
species: metaM phe L c
reaction: metaR r0365
reaction: metaR r2110
reaction: metaR r1527
reaction: metaR PNTEH
reaction: metaR r2093
species: metaM HC01376 m
reaction: metaR r1894
reaction: metaR PAIL45P HStn
reaction: metaR EX gua LPAREN e RPAREN
species: metaM cholcoa c
reaction: metaR r1605
species: metaM camp c
reaction: metaR r1260
reaction: metaR r1010
reaction: metaR RIBt
reaction: metaR r0531
reaction: metaR r1686
reaction: metaR r1627
species: metaM lys L e
species: metaM dece4coa m
species: MODEL1310110058#
reaction: metaR LEUKTRD4t
reaction: metaR PRGNLONEtm
species: metaM sphs1p e
reaction: metaR EX gbside hs LPAREN e RPAREN
species: metaM 3ddcrn c
reaction: metaR GCCcm
species: metaM tetpent6 e
reaction: metaR r2365
species: metaM dectricoa m
species: metaM frdp r
reaction: metaR SGALSIDEtg
reaction: metaR r0911
reaction: metaR r0715
species: metaM HC02180 c
species: metaM Lfmkynr c
reaction: metaR AG13T6g
species: metaM ksii core2 pre3 g
reaction: metaR r2065
reaction: metaR r2200
reaction: metaR EX pyr LPAREN e RPAREN
reaction: metaR PTPAT

http://identifiers.org/biomodels.db/MODEL1310110058#_92bd982e_2104_4669_a840_bf0ecc4a8c4e
is: SBO:0000252
has only substance units: false
is: Q8WXF9
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:66035
initial concentration: NaN
name: SLC2A11

http://identifiers.org/biomodels.db/MODEL1310110058#_3b6fe98f_b0f2_450f_81e6_f7a06e213bc3
is encoded by: hsa:522
type: Species
boundary condition: true
name: ATP5J
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM nm2masn g
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: C05884
is: SBO:0000247
type: Species
notes: FORMULA: C42H70N3O30X CHARGE: 0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_ff28b508_4e11_454d_905d_6f588fd53956
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q96EK6
type: Species
name: GNPNAT1
is: SBO:0000252
is encoded by: hsa:64841
constant: false

metaR r0781
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
modifier: MODEL1310110058#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
product: MODEL1310110058#
fast: false
is: SBO:0000176
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM rib D c
boundary condition: false
has only substance units: false
initial amount: NaN
name: D-ribose
is: HMDB00283
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:16988

http://identifiers.org/biomodels.db/MODEL1310110058#_867a912e_1f08_4d86_9c41_e74aa6f5eb7e
type: Species
name: FDFT1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P37268
constant: false
is encoded by: hsa:2222
has only substance units: false
initial amount: NaN

metaR TALA
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.2
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110058#
fast: false
reversible: true
name: transaldolase
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_2ee38345_94ce_4dd3_83bb_91f52f8eb096
name: _T83654_1_m
boundary condition: true
is encoded by: hsa:T83654
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaM dd2coa x
initial concentration: 1.0
name: trans-Dodec-2-enoyl-CoA
is: SBO:0000247
constant: false
is: HMDB03712
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
boundary condition: false
type: Species
has only substance units: false

metaR TYRt
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
name: L-tyrosine transport
is described by: ECO:0000269
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_f6686db5_60b7_4141_b3a0_65a50c2e0adf
boundary condition: true
constant: false
is: Q9BZ23
initial amount: NaN
has only substance units: false
type: Species
name: PANK2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:80025

metaR r0644
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false

metaR CYSTA
is described by: ECO:0000304
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
name: cysteine transaminase
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#

metaM cs e l
boundary condition: false
is: CHEBI:36005
is: HMDB02183
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_9870d664_ac7e_4d1c_8a51_ee2dc3163485
name: TKTL1
initial concentration: NaN
constant: false
is encoded by: hsa:8277
has only substance units: false
boundary condition: true
type: Species
is: B7Z7I0
is: SBO:0000252
initial amount: NaN

metaM lnlncacrn c
initial amount: NaN
has only substance units: false
constant: false
name: alpha-linolenyl carnitine
type: Species
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
initial concentration: 1.0
is: HMDB06319
boundary condition: false
is: SBO:0000247

metaM dudp c
is: SBO:0000247
constant: false
initial amount: NaN
name: dUDP
initial concentration: 1.0
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: C01346
has only substance units: false
is: CHEBI:60471
type: Species
boundary condition: false

metaR DMATTx
fast: false
reversible: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.5.1.1
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is described by: ECO:0000134
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
is: SBO:0000176
name: dimethylallyltranstransferase

http://identifiers.org/biomodels.db/MODEL1310110058#_f380fc20_fb17_4279_9c9b_7348793962fa
has only substance units: false
is encoded by: hsa:375056
name: MIA3
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is: Q5JRA6
type: Species
initial concentration: NaN

metaR RBTt
is: SBO:0000185
name: ribitol transport via passive diffusion
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
product: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_3b3896e4_5f7f_4875_a02e_4e40158c61d0
boundary condition: true
constant: false
type: Species
has only substance units: false
name: NDUFS8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: O00217
is encoded by: hsa:4728

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM CE2421 m
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
constant: false
initial concentration: 1.0
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB02329
is: CHEBI:30623
boundary condition: false

metaM nicrnt c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB01132
is: CHEBI:57502
name: Nicotinate D-ribonucleotide
type: Species
is: C01185
constant: false

metaR FAOXC16080m
reactant: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
fast: false
reversible: false
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR TMDS
type: Reaction
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
product: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
is described by: ECO:0000269
name: thymidylate synthase
is version of: http://identifiers.org/ec-code/2.1.1.45

metaR r1711
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
reversible: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
fast: false

metaM ksi g
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:17140
name: keratan sulfate I
has only substance units: false
is: HMDB01644
initial amount: NaN
type: Species

metaM ksi pre17 g
name: keratan sulfate I biosynthesis, precursor 17
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:28067
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_51ee92b9_929c_49f8_9c4f_cc47a5602532
has only substance units: false
constant: false
is encoded by: hsa:5152
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PDE9A
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_e0203d2d_c9ba_4d1d_a5e5_2c42b5beb9a8
has only substance units: false
name: GGT1
initial amount: NaN
boundary condition: true
is encoded by: hsa:2678
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR 13DAMPPOX
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
reversible: false
modifier: MODEL1310110058#
is described by: ECO:0000212
type: Reaction
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.4.3.21

metaM CE4790 m
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57923
constant: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r0931
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
name: Transport reaction
type: Reaction

metaM cs a l
constant: false
boundary condition: false
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
type: Species
is: HMDB02183
is: CHEBI:36005
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial concentration: 1.0

metaM so3 m
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: hydrogensulfite
type: Species
is: SBO:0000247
is: CHEBI:17137
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
constant: false
is: HMDB00240

http://identifiers.org/biomodels.db/MODEL1310110058#_09775061_b303_4bff_9c1b_a7a6a9ca92eb
initial concentration: NaN
is encoded by: hsa:80025
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PANK2
constant: false
type: Species

metaR r0642
type: Reaction
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reversible: true
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000

metaR FAOXC2252053m
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
modifier: MODEL1310110058#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110058#
reversible: false
product: MODEL1310110058#
fast: false
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110058#_30e3a7c8_09e0_476b_92c7_95bbad5af14b
is: A8K3T7
name: CHIA
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:27159

http://identifiers.org/biomodels.db/MODEL1310110058#_dc2559c0_fa83_4d37_8049_deeb34998f21
type: Species
name: SLC28A1
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q96PL7
is encoded by: hsa:9154
initial concentration: NaN
constant: false
boundary condition: true

metaR r0932
fast: false
reversible: true
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110058#
name: Transport reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaR NDP8
is described by: ECO:0000269
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
name: nucleoside-diphosphatase (dUDP)
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.9
type: Reaction
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_87e391ae_365d_48a5_b25d_257e63d78050
constant: false
boundary condition: true
type: Species
is: P36021
name: SLC16A2
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6567

metaM sebcoa x
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: sebacoylcoa
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H47N7O19P3S CHARGE: -5

metaR RE3245C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reversible: true
reactant: MODEL1310110058#
name: RE3245
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000176

metaM 2maacoa m
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157
is: SBO:0000247
is: CHEBI:57335
initial amount: NaN
name: 2-methylacetoacetyl-CoA(4-)

metaM naglc2p L c
initial concentration: 1.0
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
is: CHEBI:18278
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
has only substance units: false
boundary condition: false

metaM ksi e
initial amount: NaN
is: CHEBI:17268
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00211
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_1ca2d479_1d53_4227_b215_0d08a3bedcd9
initial amount: NaN
is: Q38G75
is encoded by: hsa:2582
has only substance units: false
type: Species
name: GALE
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_51f49b71_1b6e_4217_9cc6_eaaa951c48f7
is: SBO:0000252
initial concentration: NaN
is: B7Z6Q4
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:3612
name: IMPA1
initial amount: NaN

metaR r0074
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110058#
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction

metaM orot c
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00226
has only substance units: false
is: CHEBI:30839
name: Orotate
is: C00295
type: Species

metaM lgt S c
constant: false
is: SBO:0000247
is: HMDB01066
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
name: (R)-S-lactoylglutathionate(1-)
initial concentration: 1.0
is: CHEBI:57474
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR CO2t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is: SBO:0000185
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
name: CO2 transporter via diffusion
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_2decc711_b11d_446f_993a_f0cc7b8e638d
has only substance units: false
is: SBO:0000252
name: _AI291895_1_c
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI291895

http://identifiers.org/biomodels.db/MODEL1310110058#_40e34a28_49f0_4409_869d_cb81bf5b495b
is: SBO:0000252
initial amount: NaN
name: PDE8A
has only substance units: false
is encoded by: hsa:5151
initial concentration: NaN
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_632eeacf_4858_49f7_b6e2_1f18cbf7b629
name: CROT
boundary condition: true
constant: false
is: E7EQF2
is encoded by: hsa:54677
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM dctp c
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
boundary condition: false
initial concentration: 1.0
is: C00458
is: CHEBI:16311
is: HMDB00998
has only substance units: false

metaR HYPTROXe
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: HYPTROXe
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110058#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_b371e460_f154_410a_bac2_0c60baa6de5c
is: O75874
initial amount: NaN
boundary condition: true
is encoded by: hsa:3417
type: Species
name: IDH1
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR r0641
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110058#

metaR SEBCOACROT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_c525189e_1676_435f_95d5_4ea55bc9ebc8
initial amount: NaN
boundary condition: true
name: OGDH
is encoded by: hsa:4967
is: SBO:0000252
is: Q02218
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaM ptdcacoa c
is: SBO:0000247
has only substance units: false
is: HMDB06499
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
type: Species
initial amount: NaN
name: pentadecanoyl Coenzyme A
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_2caa374e_6fc7_4d5c_9486_dbda9d2246fc
name: SLC7A8
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:23428
is: Q86U05
is: SBO:0000252

metaM 2obut c
is: CHEBI:16763
constant: false
is: SBO:0000247
is: C00109
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
name: 2-Oxobutanoate
is: HMDB00005
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5bcb4ced_6045_4e9b_bdd9_9554ec02c125
type: Species
name: RDH11
is: B4DDW0
is encoded by: hsa:51109
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaR EX arachcoa LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: arachidyl coenzyme A exchange
type: Reaction

metaR AG13T3g
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110058#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction

metaM m1mpdol L c
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
has only substance units: false

metaM camp c
initial amount: NaN
has only substance units: false
is: CHEBI:58165
name: 3',5'-cyclic AMP(1-)
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB00058
initial concentration: 1.0

metaM acnam c
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: N-acetylneuraminate
type: Species
is: CHEBI:35418
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_553e9d57_dac4_4f08_b3dc_e929d93afabe
is: SBO:0000252
is encoded by: hsa:4731
initial amount: NaN
initial concentration: NaN
name: NDUFV3
type: Species
has only substance units: false
constant: false
boundary condition: true

metaM orot e
initial amount: NaN
name: orotate
is: CHEBI:30839
boundary condition: false
has only substance units: false
type: Species
is: HMDB00226
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

metaR CERT1rt
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is described by: ECO:0000304
product: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
name: ceramide transport protein
is: SBO:0000185
reactant: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_74a45b1e_ccb1_4875_a1db_138eede1bf8b
type: Species
boundary condition: true
is: P23219
is encoded by: hsa:5742
initial amount: NaN
name: PTGS1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaR HMGCOARc
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
reversible: false
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#

metaR HDCAtr
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
reversible: true
name: fatty acid transport via diffusion

metaM 4hpro LT m
initial amount: NaN
has only substance units: false
constant: false
name: trans-4-hydroxy-L-proline
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:18095
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690

http://identifiers.org/biomodels.db/MODEL1310110058#_5cfcd99d_277d_451a_a714_20096848ed32
has only substance units: false
boundary condition: true
is encoded by: hsa:8608
is: SBO:0000252
initial amount: NaN
constant: false
name: RDH16
is: O75452
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_b3aaa2aa_6c97_41fd_bd9a_3d6ff6c5d6be
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4714
initial amount: NaN
is: O95169
type: Species
name: NDUFB8
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_52c13d97_3252_4b78_98cb_342f44d44f42
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P04746
type: Species
name: AMY2A
initial amount: NaN
is encoded by: hsa:279
initial concentration: NaN
constant: false

metaM thr L c
is: CHEBI:16857
name: L-threonine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
is: HMDB00167
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN

metaR RE3626M
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110058#
product: MODEL1310110058#
name: RE3626
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction

metaM c4crn e
is: SBO:0000247
boundary condition: false
is: HMDB02013
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: butyryl carnitine
is: http://identifiers.org/pubchem.compound/213144
is: C02862
type: Species
constant: false
notes: FORMULA: C11H21NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110058#_6ff3bbec_834b_4c76_9d23_80a06db72e35
constant: false
is: P21912
name: SDHB
is encoded by: hsa:6390
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR GULNDer
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reactant: MODEL1310110058#
is: SBO:0000176
type: Reaction
name: gulonate dehydrogenase, endoplasmic reticulum
product: MODEL1310110058#
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_9750571d_83e0_4c80_8bc5_c1247f7613d1
has only substance units: false
is encoded by: hsa:377841
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ENTPD8
initial amount: NaN
is: Q5MY95
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_a470b0e2_cfd9_4f38_b95e_a189f1c79204
is: SBO:0000252
constant: false
is encoded by: hsa:3036
initial concentration: NaN
type: Species
name: HAS1
is: Q8IYH3
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r0937
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110058#
reversible: true
is: SBO:0000185
fast: false
type: Reaction

metaM 4hpro LT c
boundary condition: false
constant: false
name: trans-4-hydroxy-L-proline
type: Species
initial amount: NaN
is: CHEBI:18095
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial concentration: 1.0
has only substance units: false
is: HMDB00725

metaR r0355
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
type: Reaction
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000

metaM spc hs c
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX c3dc
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_e8cac8d8_360a_4fee_aa41_63c24dad14cb
initial amount: NaN
constant: false
name: MCCC2
is: Q9HCC0
boundary condition: true
is encoded by: hsa:64087
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_c9470afb_2069_4407_89dc_8d2b3faaaa23
has only substance units: false
is: SBO:0000252
name: _AI935189_1_m
boundary condition: true
type: Species
is encoded by: hsa:AI935189
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_0258e66f_7d78_4425_9518_122d744fe54b
is encoded by: hsa:144195
name: SLC2A14
initial amount: NaN
boundary condition: true
is: Q8TDB8
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR FUMAC
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.7.1.2
name: fumarylacetoacetase
kinetic law: MODEL1310110058#
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_72570409_ca4c_47df_91e9_e02a8d40a2b7
is encoded by: hsa:NM 013421
type: Species
name: _NM_013421_1_e
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR LEUKTRD4tr
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
reversible: true
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: leukotriene intracellular transport

metaM tymsf c
initial amount: NaN
name: Tyramine O-sulfate
initial concentration: 1.0
is: HMDB06409
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
constant: false

metaM dag hs c
name: diglyceride
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:18035
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_ff0df35f_3f8b_408b_8c4b_da6e8d23f861
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7001
type: Species
is: P32119
initial concentration: NaN
boundary condition: true
constant: false
name: PRDX2

metaR AATAi
name: 2-aminoadipate transaminase, irreversible
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7

metaM frdp r
name: Farnesyl diphosphate
is: CHEBI:175763
constant: false
is: HMDB00961
initial amount: NaN
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
is: C00448
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_ba33ba78_d699_4bba_9339_882b77065f68
type: Species
boundary condition: true
name: ATIC
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:471
is: P31939

metaR S23T3g
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.6
modifier: MODEL1310110058#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
reversible: false
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)

metaM leu L m
is: SBO:0000247
type: Species
name: L-leucine
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
has only substance units: false
is: CHEBI:15603
constant: false
is: HMDB00687
initial amount: NaN

metaM lnlncacrn m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: alpha-linolenyl carnitine
constant: false
is: HMDB06319
has only substance units: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
type: Species

metaM dd2coa m
is: HMDB03712
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: trans-dodec-2-enoyl-CoA(4-)
initial amount: NaN
is: SBO:0000247

metaM c4crn c
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: butyryl carnitine
is: HMDB02013
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H21NO4 CHARGE: 0
is: C02862
type: Species

metaR PNTK
reversible: false
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110058#
is described by: ECO:0000269
modifier: MODEL1310110058#
name: pantothenate kinase
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110058#

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_a204df8a_60ca_4e1a_892a_42278b76df50
is encoded by: hsa:146712
name: B3GNTL1
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: Q67FW5

metaR FAOXC123C102m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR M1316Mg
product: MODEL1310110058#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.114
modifier: MODEL1310110058#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

metaR SUBERICACT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b8255dbd_0a95_49b0_8f84_097a6e5e675b
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: SCP2
is: C9JC79
is encoded by: hsa:6342
initial concentration: NaN

metaM mal L e
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00156
name: (S)-malate(2-)
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaM ptdcacoa m
initial amount: NaN
type: Species
name: pentadecanoyl Coenzyme A
is: HMDB06499
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR UMPKn
modifier: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
name: UMP kinase, nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_5c50790e_ee18_4ff0_8245_655242ee7979
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:125061
name: AFMID
is: Q63HM1
is: SBO:0000252
initial amount: NaN

metaR DOLASNT Ler
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.119
is: SBO:0000176
kinetic law: MODEL1310110058#

metaM mev R c
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:36464
has only substance units: false
initial amount: NaN
is: HMDB00227
name: (R)-mevalonate

http://identifiers.org/biomodels.db/MODEL1310110058#_915f8d05_dac1_4315_a252_0b8bb6b0c599
is: O75912
has only substance units: false
boundary condition: true
is encoded by: hsa:9162
initial amount: NaN
constant: false
type: Species
name: DGKI
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_91d7a69e_f0c7_4255_9047_eb7cbfba965e
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4716
type: Species
name: NDUFB10
is: A8K761
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

metaR THRALANaEx
is described by: ECO:0000269
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#

metaM sphmyln hs c
is: SBO:0000247
boundary condition: false
is: CHEBI:58216
constant: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: sphingomyelin betaine

http://identifiers.org/biomodels.db/MODEL1310110058#_52e4cfe8_80d7_4504_9a82_590f063fd3b7
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:29968
initial concentration: NaN
name: PSAT1
type: Species
has only substance units: false
is: Q9Y617
constant: false
boundary condition: true

metaM xolest2 hs e
is: SBO:0000247
name: cholesterol ester
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: CHEBI:17002

http://identifiers.org/biomodels.db/MODEL1310110058#_4693d565_f1c2_43bf_98cb_716eb23e0015
has only substance units: false
initial amount: NaN
is encoded by: hsa:3614
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: IMPDH1
is: C9JV30
initial concentration: NaN

metaR FUMm
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
name: fumarase, mitochondrial
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110058#

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaM mal L c
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: (S)-malate(2-)
has only substance units: false
constant: false
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
type: Species
is: CHEBI:15589

http://identifiers.org/biomodels.db/MODEL1310110058#_6e161903_05fe_402a_a22a_7857ea2871c5
is: SBO:0000252
name: ACLY
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:47

metaM n2m2masn g
constant: false
notes: FORMULA: C50H83N4O35X CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: C11530
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110058#_c0aaf763_4c5c_44fa_b553_1698521b47d2
is: O75387
name: SLC43A1
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8501
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_01edb678_35c5_40d3_b41e_533a2873abf3
constant: false
is encoded by: hsa:4712
type: Species
is: SBO:0000252
initial amount: NaN
name: NDUFB6
initial concentration: NaN
is: O95139
boundary condition: true
has only substance units: false

metaM ura c
is: SBO:0000247
initial amount: NaN
constant: false
name: Uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:17568
has only substance units: false
is: C00106
is: HMDB00300

http://identifiers.org/biomodels.db/MODEL1310110058#_a94d9750_7775_4408_9904_92b1398cc220
name: SDS
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:10993
is: P20132

http://identifiers.org/biomodels.db/MODEL1310110058#_978a8554_0868_437f_8f85_860174420ed1
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: SCD5
initial amount: NaN
boundary condition: true
is encoded by: hsa:79966
is: Q86SK9
is: SBO:0000252

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_98e7c647_3bc9_4b0e_979d_250ca3ddb8ea
has only substance units: false
is encoded by: hsa:5831
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: A6NFM2
name: PYCR1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_a3541b62_f141_483a_b9b0_d332b8506278
boundary condition: true
initial amount: NaN
is encoded by: hsa:10965
initial concentration: NaN
name: ACOT2
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is: P49753

metaR r0934
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
product: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#
reversible: false

metaM hmgcoa c
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: Hydroxymethylglutaryl-CoA
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:15467
is: HMDB01375

metaR ACNMLr
fast: false
is described by: ECO:0000000
name: N-Acetylneuraminate lyase (reversible)
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
type: Reaction
reactant: MODEL1310110058#
reversible: true
product: MODEL1310110058#
is: SBO:0000176

metaR r1599
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000185
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_8450861d_43e7_4755_aa89_784f06152c9d
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4056
name: LTC4S
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_00454e5f_2a0b_4de6_a5f4_2f12311ea8df
name: ALDH3B1
boundary condition: true
is encoded by: hsa:221
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P43353

http://identifiers.org/biomodels.db/MODEL1310110058#_e32e3a73_f0ca_4449_bbd5_acd5effdd4f9
is: SBO:0000252
constant: false
is: P19404
boundary condition: true
type: Species
is encoded by: hsa:4729
name: NDUFV2
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_a7b87e4f_d3b2_47ff_a95a_fe16af56b91d
type: Species
is: SBO:0000252
boundary condition: true
name: SLC16A8
has only substance units: false
is: O95907
initial concentration: NaN
is encoded by: hsa:23539
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5298a297_1fe7_4dd3_bd2b_a8bb7a40a07d
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:10327
boundary condition: true
name: AKR1A1

http://identifiers.org/biomodels.db/MODEL1310110058#_dd179aeb_cc2c_4b20_bc60_8b34a37c4bc8
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q9BRC7
is encoded by: hsa:84812
name: PLCD4
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_167fb6cb_e523_4128_bfed_cbf7da3d9f5b
is encoded by: hsa:9651
type: Species
is: O75038
name: PLCH2
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM didp n
is: HMDB03536
type: Species
boundary condition: false
name: dIDP
is: CHEBI:28823
constant: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM m6masnB2 g
type: Species
is: CHEBI:30825
constant: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: HMDB00573
boundary condition: false
has only substance units: false
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR FAOXC3DC
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaR STS2
is version of: http://identifiers.org/ec-code/3.1.6.2
reactant: MODEL1310110058#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
fast: false
name: Steryl-sulfatase
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ

metaM 4hpro LT e
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
name: trans-4-hydroxy-L-proline
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00725
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_fb08621e_2921_4abf_ad6d_090b01bd1748
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: CHAT
is encoded by: hsa:1103
boundary condition: true
is: D3DX95
constant: false
initial concentration: NaN
type: Species

metaR r1598
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110058#
is described by: ECO:0000000

metaM spc hs e
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5311445
type: Species
name: sphingosylphosphorylcholine
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_2b585ec0_c2e3_4eb3_a787_1c888e408614
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:8659
initial amount: NaN
boundary condition: true
name: ALDH4A1
has only substance units: false

metaM dag hs e
is: CHEBI:18035
name: diglyceride
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

metaR OXAHCOtex
is described by: ECO:0000304
kinetic law: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
type: Reaction
name: oxalate transport via bicarbonate countertransport
reversible: false
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110058#

metaM ura e
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: uracil
initial amount: NaN
type: Species
is: CHEBI:17568
boundary condition: false

metaM dctp n
has only substance units: false
type: Species
is: SBO:0000247
is: C00458
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00998
is: CHEBI:16311
initial concentration: 1.0

metaR r0354
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
product: MODEL1310110058#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000

metaR STS1
name: Steryl-sulfatase
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
type: Reaction
reversible: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.2
modifier: MODEL1310110058#

metaR r1597
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110058#
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 5pmev c
is: SBO:0000247
name: (R)-5-phosphonatomevalonate(3-)
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
has only substance units: false
is: HMDB01343
boundary condition: false
type: Species

metaR r0936
name: Transport reaction
reversible: false
product: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110058#

metaR r1595
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ibcoa m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
constant: false
is: HMDB01243
is: CHEBI:57338
name: isobutyryl-CoA(4-)
has only substance units: false

metaR MI14P4P
reactant: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
name: inositol-1,4-bisphosphate 4-phosphatase
fast: false
product: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction

metaR PGLer
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
product: MODEL1310110058#
is: SBO:0000176
type: Reaction
name: 6-phosphogluconolactonase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/1.1.1.47
fast: false
reversible: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_1ab41105_41a9_4a06_b50f_e1bcccb2fca0
type: Species
is: P36269
initial amount: NaN
is encoded by: hsa:2687
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: GGT5

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR RDH3
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
name: retinol dehydrogenase (11-cis,NADH)
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110058#_e1a2422b_4eff_46f2_9ed3_a1fe8e74f2e2
constant: false
is: Q9C0J1
type: Species
is encoded by: hsa:79369
name: B3GNT4
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r1876
reversible: false
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
name: Y+LAT2 Utilized transport

metaR r1596
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_8069b5ed_80a9_4416_b3aa_add2ee51a643
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: B7Z2M9
name: DGKZ
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:8525

metaR r0202
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8

metaR CYTK6n
reversible: true
type: Reaction
modifier: MODEL1310110058#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110058#
name: cytidylate kinase (CMP,CTP),nuclear
product: MODEL1310110058#

metaM pail hs n
type: Species
is: CHEBI:57880
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194

metaM val L m
name: L-valine
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
is: HMDB00883
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:16414

http://identifiers.org/biomodels.db/MODEL1310110058#_3aaa25d6_4b55_4f82_abe1_f2054fc5e844
type: Species
name: LDHA
boundary condition: true
is encoded by: hsa:3939
is: SBO:0000252
has only substance units: false
is: P00338
initial amount: NaN
initial concentration: NaN
constant: false

metaR PSFLIPm
is version of: http://identifiers.org/ec-code/3.6.3.1
is described by: ECO:0000269
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
name: phosphatidylserine flippase
reactant: MODEL1310110058#
reversible: false
is: SBO:0000185
modifier: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ

metaM cgly c
name: L-cysteinylglycine
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:4047
constant: false
is: HMDB00078
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
boundary condition: false
has only substance units: false

metaR RAI2
reversible: true
fast: false
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
name: retinal isomerase (9-cis)

metaR r0797
type: Reaction
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true
name: glycine N-choloyltransferase EC:2.3.1.65
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5e7be260_6f57_4a17_a18c_d6ce81adbf1d
has only substance units: false
is: Q9NPB1
type: Species
initial concentration: NaN
is encoded by: hsa:56953
boundary condition: true
is: SBO:0000252
constant: false
name: NT5M
initial amount: NaN

metaM arab L c
is: CHEBI:30849
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
boundary condition: false
is: HMDB00646
name: L-arabinose
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_a02c97c5_229a_405b_b752_f61cdae1cd5b
is: O43252
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:9061
name: PAPSS1
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_447f0e8b_6acd_4fcd_a5b5_33a82f02a69d
has only substance units: false
type: Species
is: O43306
name: ADCY6
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:112
constant: false
initial amount: NaN
boundary condition: true

metaR SUBERCACT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaR r1877
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110058#

metaR RE3244R
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
name: RE3244
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_1f286033_470e_4cb6_a4cc_55e4248f98af
is: O00746
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NME4
is encoded by: hsa:4833
boundary condition: true
constant: false
initial amount: NaN

metaR RBFK
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.26
type: Reaction
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: riboflavin kinase
product: MODEL1310110058#

metaR r1593
reversible: true
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR DPMVDc
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.1.1.33
fast: false
type: Reaction
name: diphosphomevalonate decarboxylase, cytosol
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
product: MODEL1310110058#
is: SBO:0000176

metaR CYSASNNaEx
reversible: false
kinetic law: MODEL1310110058#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185

metaM asp D e
is: CHEBI:29990
name: D-aspartate(1-)
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
type: Species
is: HMDB06483
has only substance units: false
initial amount: NaN

metaR r0796
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
fast: false
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110058#

metaR AMY1e
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
fast: false
name: alpha-amylase, extracellular (strch1 -> strch2)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_76bd863a_8267_4585_9aef_657b7b90b5b7
is encoded by: hsa:4698
has only substance units: false
initial amount: NaN
name: NDUFA5
is: SBO:0000252
is: Q16718
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaR METLEUex
name: Methionine/Leucine exchange (Met in)
reactant: MODEL1310110058#
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310

metaM thm c
type: Species
constant: false
notes: FORMULA: C12H17N4OS CHARGE: 1
is: C00378
name: Thiamin
is: HMDB00235
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:0
is: SBO:0000247
boundary condition: false

metaR RDH1
is: SBO:0000176
name: retinol dehydrogenase (all-trans)
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
type: Reaction
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110058#

metaM HC00319 c
name: Malonate
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:30794
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_0c324af9_2c38_4854_b5d1_b67538d54e8d
is: P31153
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:4144
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: MAT2A

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_038fad46_6729_4644_a086_739940200edd
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:56606
name: SLC2A9

http://identifiers.org/biomodels.db/MODEL1310110058#_5128144e_3804_40dc_a0de_d6dbb2457b87
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: E2QRH8
initial concentration: NaN
is encoded by: hsa:5332
constant: false
boundary condition: true
name: PLCB4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_2b085fbc_762d_4fbe_a5a5_a5bb53d13947
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:7264
is: Q13630
name: TSTA3
initial concentration: NaN

metaR r1594
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#

metaR UDPGD
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.22
name: UDPglucose 6-dehydrogenase
is described by: ECO:0000304
product: MODEL1310110058#
modifier: MODEL1310110058#

metaR HISCAT1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR r0795
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110058#
name: Spontaneous reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#

metaM cgly e
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: L-cysteinylglycine
is: SBO:0000247
constant: false
is: CHEBI:4047
is: HMDB00078
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaM pro L m
name: L-proline
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:17203
initial amount: NaN

metaR DOPAtu
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110058#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Dopamine uniport

metaR RDH2
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110058#
type: Reaction
name: retinol dehydrogenase (9-cis,NADH)
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true

metaR PIPLC
name: phosphatidylinositol phospholipase C
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110058#

metaM leu L e
initial amount: NaN
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine
constant: false
is: HMDB00687
is: CHEBI:15603
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ddd00d7a_0437_4fb5_bc1c_2f5eb66ef2a5
is: P43251
type: Species
is encoded by: hsa:686
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: BTD
initial concentration: NaN
has only substance units: false

metaM HC02217 c
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
type: Species
is: CHEBI:27647
initial concentration: 1.0
is: SBO:0000247
constant: false
name: prostaglandin-g2

metaM xoltetrol c
has only substance units: false
is: HMDB01231
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
initial amount: NaN
type: Species
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17278
boundary condition: false

metaR D LACt2
name: D-lactate transport via proton symport
is described by: ECO:0000269
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true
type: Reaction
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#

metaM dcsptn1crn m
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false
is: SBO:0000247
is: HMDB06321
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+

http://identifiers.org/biomodels.db/MODEL1310110058#_482e15e5_b7f0_4513_9b0c_3655020ec7ff
name: B4GALT3
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8703
is: A8K5Z0
constant: false

metaM 5adtststerone e
is: SBO:0000247
is: HMDB02961
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
has only substance units: false
is: CHEBI:16330
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR METtec
type: Reaction
product: MODEL1310110058#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
reversible: true
name: L-methionine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110058#_d4bdaea1_189f_4f3d_92dc_e836f3775a89
is: Q6IBC4
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: NDUFS6
is: SBO:0000252
is encoded by: hsa:4726

http://identifiers.org/biomodels.db/MODEL1310110058#_70be8c08_fac7_4946_8a09_625f94e26317
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is: Q92947
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2639
boundary condition: true
name: GCDH

metaR 4MPTNLte
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is: SBO:0000185
reactant: MODEL1310110058#
name: 4-methylpentanal transport
product: MODEL1310110058#
fast: false
type: Reaction
kinetic law: MODEL1310110058#
reversible: true

metaR DGTPtn
is described by: ECO:0000000
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
type: Reaction
reversible: true
name: dGTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185

metaR r1592
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR NMNATr
is: SBO:0000176
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.7.1
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110058#
reversible: true
type: Reaction
name: nicotinamide-nucleotide adenylyltransferase
is described by: ECO:0000269
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_1a7dfb4f_2ef3_4abd_8467_fede5152b6ca
constant: false
type: Species
name: LDHAL6B
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:92483
is: SBO:0000252
is: Q9BYZ2

http://identifiers.org/biomodels.db/MODEL1310110058#_2cd28f1a_2740_41d9_a59f_bb23f1bf491a
name: AGPAT4
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: Q9NRZ5
constant: false
is: SBO:0000252
is encoded by: hsa:56895

http://identifiers.org/biomodels.db/MODEL1310110058#_1ae5e7e3_44f9_4974_80ae_160782a4b8a8
constant: false
is: SBO:0000297
is encoded by: hsa:517
type: Species
initial amount: NaN
has part: F8W7V3
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:9551
boundary condition: true
initial concentration: NaN

metaR PHCHGSm
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
reversible: true
type: Reaction
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reactant: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_0773cecd_6677_4b91_a6b3_36904cd71273
initial concentration: NaN
is encoded by: hsa:6560
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: F5H066
has only substance units: false
name: SLC12A4

metaR RE1530C
reactant: MODEL1310110058#
name: RE1530
reversible: true
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false

metaM HC02217 e
constant: false
is: CHEBI:27647
initial concentration: 1.0
name: prostaglandin-g2
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
has only substance units: false

metaR r2403
reactant: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM 5adtststerone c
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
is: CHEBI:16330
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_cdbad57e_3ffb_422b_9587_683a6a5b775e
name: ALDH3A2
is encoded by: hsa:224
initial amount: NaN
is: P51648
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_a6dd9b3e_b843_4c0b_b6b8_062cff2c1137
constant: false
is: SBO:0000252
is encoded by: hsa:4709
is: Q6IB80
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: NDUFB3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_f6502406_7e88_490c_a135_c3512a17b994
is encoded by: hsa:54344
name: DPM3
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is: Q86TM7
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_3310edec_6aa0_433b_b3a1_72cbc73ebf2c
type: Species
name: DCTD
is encoded by: hsa:1635
has only substance units: false
is: P32321
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR RAI4
product: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
kinetic law: MODEL1310110058#
name: 13-cis-4-oxo-retinoic acid isomerase
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_974663f8_ab5e_460d_a8fd_df0994fc505c
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR ATPtx
is: SBO:0000185
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: ATP transporter, peroxisomal
reactant: MODEL1310110058#
reversible: true
fast: false
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaR r1590
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_384d17d3_4529_4e8f_9b73_341177d97421
has only substance units: false
type: Species
constant: false
name: PDE1C
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5137
is: Q8NB10

metaM arab L e
boundary condition: false
is: CHEBI:30849
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: L-arabinose
is: SBO:0000247
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_7a5d48f4_480e_46e7_af5b_39f80f4793cd
constant: false
name: NDUFA11
has only substance units: false
boundary condition: true
is: C9JT23
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:126328

metaM lnlncg r
name: gamma-linolenate
is: HMDB03073
is: SBO:0000247
boundary condition: false
is: CHEBI:32391
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR NDPK2n
reversible: true
modifier: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
kinetic law: MODEL1310110058#
fast: false
type: Reaction

metaM methf c
boundary condition: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
name: 5,10-Methenyltetrahydrofolate
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: HMDB01354
initial concentration: 1.0
is: CHEBI:57455

metaR r0208
reactant: MODEL1310110058#
reversible: true
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.4.1.1
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
modifier: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
fast: false

metaR C14STRr
is described by: ECO:0000134
fast: false
modifier: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110058#
reversible: false
is: SBO:0000176
name: C-14 sterol reductase
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ

metaM lpchol hs e
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:60479
name: lysophosphatidylcholine
boundary condition: false
type: Species
has only substance units: false

metaR GLYCtm
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
reversible: true
name: glycerol transport
is described by: ECO:0000000
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV

metaR r2405
reversible: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110058#
type: Reaction
fast: false
product: MODEL1310110058#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185

metaR P45027A11m
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110058#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
reversible: false
is: SBO:0000176
fast: false

metaR r2506
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110058#
name: Utilized transport
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_1888ff73_809c_4485_9bba_b022a658ea76
constant: false
is: SBO:0000252
is encoded by: hsa:60490
has only substance units: false
initial concentration: NaN
type: Species
is: Q96CD2
boundary condition: true
initial amount: NaN
name: PPCDC

metaR q10tm
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
reversible: true
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
name: transport of ubiquinone into mitochondria

http://identifiers.org/biomodels.db/MODEL1310110058#_9fc77d33_24ad_45f5_b2ab_57dcd1cfa661
initial concentration: NaN
is: Q96E98
is: SBO:0000252
name: RHAG
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:6005

http://identifiers.org/biomodels.db/MODEL1310110058#_f813d0c3_402b_46ce_a50c_04e63d2be3f5
name: NDUFS2
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:4720
has only substance units: false
is: SBO:0000252
is: B7Z792
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_6f2e2e1b_f7ea_4e95_9e2d_9004ebd85110
is encoded by: hsa:2629
name: GBA
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is: B7Z6S1
constant: false
initial amount: NaN
initial concentration: NaN

metaR DOLMANP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110058#
is: SBO:0000185
type: Reaction
fast: false
name: dolichol-phosphate mannose flippase (liver)

http://identifiers.org/biomodels.db/MODEL1310110058#_1e79c63e_6052_46ee_999e_66cffdbd285a
is: SBO:0000252
type: Species
initial concentration: NaN
is: P19971
has only substance units: false
is encoded by: hsa:1890
constant: false
initial amount: NaN
boundary condition: true
name: TYMP

http://identifiers.org/biomodels.db/MODEL1310110058#_488f2f61_12ec_4c0c_9a06_cc8674673ca8
is: Q9NP59
is: SBO:0000252
type: Species
is encoded by: hsa:30061
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: SLC40A1
boundary condition: true

metaR MLTG1e
name: Maltodextrin glucosidase (maltotriose), extracellular
type: Reaction
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:JLR
is version of: http://identifiers.org/ec-code/3.2.1.20
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000269

metaR FAOXC101C102m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_1626e8ea_5bbc_49da_9c64_8068a6dcb71e
name: SULT1A3
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: Q1ET61
is encoded by: hsa:6818
is: SBO:0000252
initial amount: NaN

metaM methf m
is: HMDB01354
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
name: (6R)-5,10-methenyltetrahydrofolate
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57455
initial amount: NaN

metaM dha e
is: HMDB01882
constant: false
name: glycerone
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16016

metaM lpchol hs c
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:60479
name: lysophosphatidylcholine
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR ABTti
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
name: L-arabinitol transport via passive diffusion
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110058#
type: Reaction

metaM dudp m
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species
has only substance units: false
constant: false
is: HMDB01000
name: dUDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110058#_2e2122ca_ad5d_4be0_a343_f4f50aa86826
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: PPA1
has only substance units: false
is: SBO:0000252
is: Q15181
is encoded by: hsa:5464

metaR G16MT L
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: false
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_87592800_31ed_4608_8b1a_bafb090e14c8
is encoded by: hsa:6389
initial amount: NaN
name: SDHA
initial concentration: NaN
has only substance units: false
is: P31040
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaM didp c
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:28823
is: SBO:0000247
name: dIDP
constant: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
boundary condition: false
is: HMDB03536

metaM tetdecdicoa m
type: Species
initial concentration: 1.0
is: HMDB02288
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
has only substance units: false
constant: false
is: SBO:0000247
name: 5,8-tetradecadienoylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_ed620e00_21f4_4a0b_9cdf_5ee8576272e3
initial amount: NaN
is encoded by: hsa:1431
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: CS
constant: false
is: SBO:0000252
is: O75390

metaR r0638
reversible: true
type: Reaction
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
reactant: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.2
modifier: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_b2a104aa_c1ae_49b6_a53e_fe4d1a491188
boundary condition: true
is: Q01433
is encoded by: hsa:271
constant: false
is: SBO:0000252
has only substance units: false
name: AMPD2
initial concentration: NaN
type: Species
initial amount: NaN

metaM frdp c
is: HMDB00961
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
name: Farnesyl diphosphate
is: C00448
constant: false
is: CHEBI:175763
type: Species
has only substance units: false

metaR r2507
fast: false
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110058#
product: MODEL1310110058#

metaM 3hpp m
is: HMDB00700
is: CHEBI:16510
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
name: 3-hydroxypropionate

metaR r1453
is: SBO:0000176
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
fast: false
reversible: true

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_9a3062cb_99fe_4122_a1f7_b047dffb0467
has only substance units: false
constant: false
boundary condition: true
type: Species
name: PDE7B
is: SBO:0000252
is: Q9NP56
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27115

metaM HC00319 m
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: Malonate
has only substance units: false
is: CHEBI:30794

http://identifiers.org/biomodels.db/MODEL1310110058#_173d9df6_91d1_4db2_b8af_0e5717c174a2
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5161
name: PDHA2
is: SBO:0000252
is: P29803

metaR 4MPTNLtm
reversible: true
name: 4-methylpentanal transport (mitochondria)
fast: false
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110058#
reactant: MODEL1310110058#

metaM Ser Gly Ala X Gly l
boundary condition: false
name: protein-linked serine residue (glycosaminoglycan attachment site)
notes: FORMULA: XH CHARGE: 0
is: HMDB02183
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:36005

metaM asp D c
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
initial concentration: 1.0
initial amount: NaN
name: D-aspartate(1-)
is: SBO:0000247
is: HMDB06483
is: CHEBI:29990

http://identifiers.org/biomodels.db/MODEL1310110058#_0acd3d9a_7af1_4994_ae1a_42692491c906
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P07203
boundary condition: true
name: GPX1
is encoded by: hsa:2876

http://identifiers.org/biomodels.db/MODEL1310110058#_db8f0680_efd1_443a_abb4_f86a1a1c9c42
type: Species
is: F5GWS5
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ADCY10
has only substance units: false
constant: false
is encoded by: hsa:55811
boundary condition: true

metaR FAOXC122C101m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR DIDPtn
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
name: dIDP nuclear transport
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
reversible: true

metaM leu L c
name: L-leucine
boundary condition: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:15603
has only substance units: false
initial amount: NaN
is: HMDB00687

metaR r1459
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
fast: false
name: Transport reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaM dudp n
is: SBO:0000247
is: HMDB01000
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
boundary condition: false
has only substance units: false
name: dUDP(3-)
initial concentration: 1.0
is: CHEBI:60471
initial amount: NaN

metaR AICARte
is described by: ECO:0000134
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110058#
type: Reaction
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR r2408
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110058#

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM lnlncg l
constant: false
initial concentration: 1.0
is: SBO:0000247
name: gamma-linolenate
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: HMDB03073
has only substance units: false
is: CHEBI:32391

http://identifiers.org/biomodels.db/MODEL1310110058#_407c6d12_cadd_4378_8605_8c121176e4fe
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PDE9A
type: Species
initial concentration: NaN
is encoded by: hsa:5152

metaR SBT Dtde
product: MODEL1310110058#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
name: D-sorbitol transport, extracellular
kinetic law: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reactant: MODEL1310110058#
fast: false

metaR FAOXC183803m
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:3, n-3 -> c8:0 - 5 rounds of beta ox, lose 3 degrees of unsat - only 2 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110058#

metaM ksi pre32 g
is: CHEBI:28067
initial amount: NaN
has only substance units: false
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 32
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_8d537339_4fd1_4454_b067_eb5db6e4081b
is encoded by: hsa:3098
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P78542
constant: false
type: Species
has only substance units: false
name: HK1
boundary condition: true

metaR DECDICRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_95834ef8_4557_4e81_832d_f3fe5b871fb7
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: ADSS
is encoded by: hsa:159
has only substance units: false
is: SBO:0000252
constant: false
is: P30520

metaM 13 cis oretn c
is: CHEBI:35291
constant: false
is: HMDB01852
boundary condition: false
notes: FORMULA: C20H27O3 CHARGE: -1
type: Species
name: 13-cis-oxo-retinoic acid
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM sebcoa c
name: sebacoylcoa
type: Species
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00651

http://identifiers.org/biomodels.db/MODEL1310110058#_1e198581_44df_41d1_85fa_5bec0184faaa
name: COX5A
type: Species
is encoded by: hsa:9377
is: P20674
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaR KCC2t
type: Reaction
is: SBO:0000185
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
fast: false
is described by: ECO:0000269
name: K+-Cl- cotransporter (NH4+)
kinetic law: MODEL1310110058#

metaR C40CPT1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaR EX c10crn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

metaM dcsptn1crn c
name: docosa-4,7,10,13,16-pentaenoyl carnitine
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB06321

metaM ile L m
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
name: L-isoleucine
is: CHEBI:17191
is: HMDB00172
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_0030e180_bf33_4808_bab3_89156ceb496f
is: P30566
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:158
type: Species
name: ADSL
constant: false
boundary condition: true
initial amount: NaN

metaR C16DCc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

metaR LEUKTRA4t
type: Reaction
name: leukotriene A4 transport
is described by: ECO:0000269
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
is: SBO:0000185
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
reversible: true

metaM CE0693 m
initial concentration: 1.0
is: CHEBI:28387
is: HMDB11123
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
name: 3-oxolaur-6-cis-enoyl-CoA

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR ACCOALm
modifier: MODEL1310110058#
is: SBO:0000176
name: acetate-CoA ligase (AMP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.1
fast: false
product: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
is described by: ECO:0000304
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction

metaR r0634
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: true
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110058#
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_3990b9ac_e8b1_4209_968a_a8420a8991c5
constant: false
name: SULT1A1
initial amount: NaN
is encoded by: hsa:6817
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR CRNtx
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
kinetic law: MODEL1310110058#
name: carnitine transport peroxisome to mitochondria
is: SBO:0000185
reversible: true
product: MODEL1310110058#
type: Reaction

metaR r0791
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reversible: true
fast: false
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_2f960277_5422_410f_9ba9_082fe91454f1
type: Species
initial concentration: NaN
name: ADH1B:ADH1C
has only substance units: false
is: SBO:0000297
is encoded by: hsa:126
initial amount: NaN
boundary condition: true
constant: false
has part: P00326

http://identifiers.org/biomodels.db/MODEL1310110058#_a49f6bc9_a35a_4575_a3c3_5cbcc289f8b4
type: Species
boundary condition: true
constant: false
is encoded by: hsa:23428
name: SLC7A8
initial amount: NaN
is: SBO:0000252
is: Q9UHI5
has only substance units: false
initial concentration: NaN

metaM HC02179 c
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:34306
has only substance units: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
name: 20-hydroxy-arachidonate

metaM HC02204 c
initial amount: NaN
is: CHEBI:27624
name: prostaglandin-b1
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_15a083ba_5503_438c_8fa9_d956b78f1ae2
initial concentration: NaN
is: O43570
has only substance units: false
is encoded by: hsa:771
type: Species
name: CA12
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_743ef2d3_890d_46ca_ad00_8672e5e3a5c5
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: P47895
is: SBO:0000252
initial concentration: NaN
name: ALDH1A3
is encoded by: hsa:220
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_2ee9a2b5_7944_41de_bcaf_49d8040935c5
type: Species
constant: false
has only substance units: false
is encoded by: hsa:H77542
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _H77542_1_r

metaR FRDPtr
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_2b568101_1661_417f_9589_fe31eee0a57c
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q53XN1
has only substance units: false
name: COX8A
initial concentration: NaN
type: Species
is encoded by: hsa:1351
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ae66ac11_2ca3_49bc_9a64_8185afbb3e0f
name: FOLR1
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2348
constant: false

metaM duri c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16450
initial amount: NaN
has only substance units: false
is: C00526
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
name: Deoxyuridine

metaR IVCRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaR RE1845C
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
reversible: true
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
name: RE1845
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_aee2b033_37a6_4887_8ee9_9a511a459fa2
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6785
constant: false
name: ELOVL4
boundary condition: true
is: Q9GZR5
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_a5b66f14_78cc_4eb4_b87a_45e968199a80
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23305
is: B2RB13
is: SBO:0000252
name: ACSL6
has only substance units: false
constant: false
boundary condition: true
type: Species

metaM 3sala m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: C00606
is: CHEBI:61085
is: SBO:0000247
constant: false
has only substance units: false
name: 3-sulfino-L-alanine (1-)

http://identifiers.org/biomodels.db/MODEL1310110058#_6db662f9_33b0_4ee1_a1a6_0b5bb3957940
boundary condition: true
name: PCBD1
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5092
initial amount: NaN
type: Species
is: P61457

metaM c16dc e
is: HMDB00712
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C23H42NO6 CHARGE: -1
name: Hexadecanedioic acid mono-L-carnitine ester
is: SBO:0000247
constant: false
initial amount: NaN

metaM btn e
is: C00120
type: Species
is: SBO:0000247
constant: false
is: CHEBI:3420
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00030
name: Biotin
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_c9e128d0_5847_4a5d_b620_14916f67d37b
boundary condition: true
name: AHCYL1
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10768
is: SBO:0000252
constant: false
type: Species

metaR PPItx
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
fast: false
product: MODEL1310110058#
type: Reaction
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
is described by: ECO:0000000

metaR r1912
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110058#
reversible: false
type: Reaction
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR r0545
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110058#
modifier: MODEL1310110058#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is: SBO:0000176
reversible: true

metaR r1811
is: SBO:0000185
reversible: false
modifier: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_de01d01f_d2ba_443c_946b_002cf8f02ba8
is: Q96P26
is encoded by: hsa:93034
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: NT5C1B

http://identifiers.org/biomodels.db/MODEL1310110058#_b69d059e_32c7_431b_90bd_440ae65d7702
constant: false
is encoded by: hsa:54963
initial amount: NaN
is: Q53HM1
has only substance units: false
initial concentration: NaN
name: UCKL1
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_799012b5_cc0d_4b64_a74a_8edddf9b5410
boundary condition: true
name: COX3
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4514
has only substance units: false
is: P00414

metaR HSD3B11
modifier: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: false
is: SBO:0000176
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
is described by: ECO:0000134
reactant: MODEL1310110058#

metaM cs a deg2 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: CHEBI:15748
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00127
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_53867513_7ef1_481c_be52_134cb9eae8b9
type: Species
boundary condition: true
is: Q9H2X9
initial concentration: NaN
is encoded by: hsa:57468
is: SBO:0000252
initial amount: NaN
name: SLC12A5
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_418e8f69_7874_4011_a81f_3c5a26aa021f
initial concentration: NaN
boundary condition: true
is: P55084
type: Species
is: SBO:0000252
name: HADHB
is encoded by: hsa:3032
initial amount: NaN
constant: false
has only substance units: false

metaM hexe3coa m
has only substance units: false
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
name: 3-hexenoylcoa
constant: false
initial amount: NaN
type: Species
is: HMDB06522

metaM HC00695 m
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:17432
name: S-Succinyldihydrolipoamide
boundary condition: false
initial concentration: 1.0

metaM HC02204 e
is: CHEBI:27624
boundary condition: false
is: SBO:0000247
name: prostaglandin-b1
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM duri e
is: HMDB00012
name: Deoxyuridine
initial concentration: 1.0
is: CHEBI:16450
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: C00526

metaR C10DCCACT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR r0437
is version of: http://identifiers.org/ec-code/4.1.2.13
fast: false
reactant: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110058#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110058#
is: SBO:0000176

metaR TETHEX3t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
is: SBO:0000185

metaR CMPSASn
is version of: http://identifiers.org/ec-code/2.7.7.43
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000304
modifier: MODEL1310110058#
name: CMP sialic acid synthase, nuclear
fast: false
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD

metaR r2050
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_b874ccdf_0bd5_4181_946f_c4aa7a2a2b48
constant: false
name: GLB1
is encoded by: hsa:2720
is: P16278
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_abcefffe_f491_4ef9_a867_e63331b3b79a
is: Q6IA69
has only substance units: false
name: NADSYN1
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:55191

metaR ADPCOACROT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaM pac c
constant: false
is: HMDB00209
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
type: Species
name: phenylacetate
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:18401

http://identifiers.org/biomodels.db/MODEL1310110058#_7c22b26a_6f68_4192_97e7_2a9b5eeaa109
boundary condition: true
type: Species
is encoded by: hsa:2530
constant: false
is: Q9BYC5
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: FUT8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_2e544c89_e19c_4806_b1ef_9800080388b1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:NM 013421
name: _NM_013421_1_m
is: SBO:0000252

metaM btn c
boundary condition: false
is: CHEBI:3420
constant: false
has only substance units: false
is: HMDB00030
initial concentration: 1.0
is: C00120
name: Biotin
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial amount: NaN
is: SBO:0000247

metaM ksii core2 pre5 g
notes: FORMULA: C61H99N5O43X CHARGE: -1
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
is: HMDB00175
has only substance units: false
constant: false
type: Species
is: C00130

metaM g2m8mpdol L r
constant: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: C05870
is: SBO:0000247
has only substance units: false
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20

metaR CMPSAS
is described by: ECO:0000304
type: Reaction
name: CMP sialic acid synthase
is version of: http://identifiers.org/ec-code/2.7.7.43
reversible: false
product: MODEL1310110058#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110058#_1f77ce19_a372_4113_acf2_6248676ddb08
boundary condition: true
constant: false
is: Q9NY65
type: Species
has only substance units: false
is encoded by: hsa:1962
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: EHHADH

http://identifiers.org/biomodels.db/MODEL1310110058#_00fecbcf_73cb_4f0f_82d0_30115f177181
is: SBO:0000252
name: EGFL8
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:80864
is: Q99944
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_3399f9e3_fc54_44bd_8a6c_276d83845059
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:6549
name: SLC9A2
initial concentration: NaN
boundary condition: true
type: Species
is: Q9UBY0

metaM gdp m
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
has only substance units: false
is: CHEBI:58189
boundary condition: false
constant: false
name: GDP
initial concentration: 1.0
is: C00035
is: HMDB01201
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_fb8d72fe_f78e_49bd_8359_01927e0aef3d
is: P09972
type: Species
has only substance units: false
boundary condition: true
name: ALDOC
initial concentration: NaN
is encoded by: hsa:230
initial amount: NaN
constant: false
is: SBO:0000252

metaR r1375
name: Transport reaction
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185

metaR r1600
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110058#
fast: false

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM fad e
is: C00016
initial concentration: 1.0
is: HMDB01248
boundary condition: false
has only substance units: false
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_fc37cece_44e5_4f14_abf1_4d33871835cb
initial concentration: NaN
is encoded by: hsa:522
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
initial amount: NaN
constant: false
boundary condition: true
type: Species
has part: Q6IB54
has only substance units: false

metaM thcholstoic c
initial concentration: 1.0
has only substance units: false
is: HMDB03873
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
is: CHEBI:18402
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_0a46be7b_2c0d_4e47_afe2_6ac92c462ca1
is encoded by: hsa:AI440329
initial amount: NaN
constant: false
type: Species
name: _AI440329_1_r
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM ksi pre13 g
is: CHEBI:58053
is: C00130
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 13
is: HMDB00175
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
type: Species

metaR FAS160COA
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C16:0CoA)
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
fast: false
product: MODEL1310110058#
reversible: false
is: SBO:0000176

metaR r2472
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
reactant: MODEL1310110058#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.4.7
reversible: false
type: Reaction
fast: false
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#

metaR r0541
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
kinetic law: MODEL1310110058#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110058#
type: Reaction
fast: false
is: SBO:0000176

metaR PPA
fast: false
is described by: ECO:0000269
reactant: MODEL1310110058#
modifier: MODEL1310110058#
name: inorganic diphosphatase
reversible: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1

metaR r0321
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.3.5.2
is described by: ECO:0000000
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reversible: false
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
type: Reaction
is: SBO:0000176

metaR r0434
modifier: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_7ab16eee_5a64_43cb_b1ef_4875c845dce8
initial concentration: NaN
boundary condition: true
name: SLC17A3
is: O00476
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:10786
initial amount: NaN
constant: false

metaR UDPtl
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
name: udp intracellular transport
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR CYSGLNNaEx
type: Reaction
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
fast: false
is: SBO:0000185
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
kinetic law: MODEL1310110058#

metaR NTD1
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
name: 5'-nucleotidase (dUMP)
product: MODEL1310110058#

metaR r0755
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
kinetic law: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
reversible: true

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM HC02179 e
name: 20-hydroxy-arachidonate
constant: false
is: CHEBI:34306
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
initial amount: NaN
type: Species

metaR r1377
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
reactant: MODEL1310110058#

metaM C02528 c
initial concentration: 1.0
type: Species
is: CHEBI:36234
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
constant: false
initial amount: NaN
name: chenodeoxycholate

metaM pe hs c
name: phosphatidylethanolamine
constant: false
is: CHEBI:16038
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
initial concentration: 1.0

metaR FAOXC226C225m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR EX c101crn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_ba844ca1_534b_4d6e_b586_1220aebfbdff
type: Species
is: SBO:0000252
has only substance units: false
name: SLC2A13
constant: false
boundary condition: true
is: Q96QE2
initial amount: NaN
is encoded by: hsa:114134
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_17ec6d5f_2b65_4925_b0c5_8cdee336d694
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: GUCY2D
is: Q02846
initial amount: NaN
boundary condition: true
is encoded by: hsa:3000
constant: false

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_287684da_416f_44c2_b121_9c8b200f148c
is encoded by: hsa:204
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: P54819
name: AK2
type: Species
boundary condition: true
initial amount: NaN

metaM gdp n
is: HMDB01201
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:58189
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
initial concentration: 1.0
name: GDP(3-)

metaR NTD3
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
name: 5'-nucleotidase (dCMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#

metaR r1378
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110058#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_086d2083_7428_49dd_9b0b_7a6a7a9ff1b1
is encoded by: hsa:85365
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9H553
name: ALG2
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaM thbpt4acam c
boundary condition: false
is: CHEBI:15374
constant: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
type: Species
initial concentration: 1.0

metaM ivcoa c
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01113
type: Species
name: Isovaleryl-CoA
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR TDCHOLAtx
is described by: ECO:0000000
name: bile acid intracellular transport
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
type: Reaction
is: SBO:0000185

metaR ASNtN1
fast: false
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
is: SBO:0000185
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_ea11278b_d98d_48dc_9a6a_c308230800a3
is: SBO:0000297
initial concentration: NaN
boundary condition: true
name: SLC7A8:SLC3A2
initial amount: NaN
type: Species
has only substance units: false
has part: Q86U05
constant: false
is encoded by: hsa:23428

http://identifiers.org/biomodels.db/MODEL1310110058#_91320763_5355_42f5_b0a2_1ffeb618438a
is: Q56NI9
is: SBO:0000252
has only substance units: false
name: ESCO2
is encoded by: hsa:157570
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_6b0c5ea0_bfbd_4f1f_93bf_55a16bcc6b22
constant: false
initial concentration: NaN
is encoded by: hsa:55276
name: PGM2
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q96G03
initial amount: NaN

metaM cs a deg3 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15748
is: HMDB00127

metaR MM5cg
reactant: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110058#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
fast: false
type: Reaction

metaR TSTSTERONEtr
reactant: MODEL1310110058#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: testosterone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110058#
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_1569029b_9a6f_4dc6_bb1f_c22867e59d04
name: TXNRD1
is encoded by: hsa:7296
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_b87a8441_a513_4d0f_a9a4_41600eeb02b5
is encoded by: hsa:100
is: P00813
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ADA

http://identifiers.org/biomodels.db/MODEL1310110058#_41eec1c5_22b8_4a8f_aa89_266907a71f05
has only substance units: false
name: _AI378339_1_m
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI378339

metaM pe hs e
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: SBO:0000247
type: Species
name: phosphatidylethanolamine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_03da9847_3d80_44c1_ab27_d95070d5f202
boundary condition: true
is: P28329
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1103
name: CHAT
type: Species

metaM cholcoar r
boundary condition: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: HMDB02178
is: SBO:0000247
is: CHEBI:58677
constant: false

metaR SPHS1Ptr
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: sphingosine-1-phosphate transport
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
product: MODEL1310110058#

metaR r0651
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110058#

metaM ivcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: CHEBI:57345
is: HMDB01113
name: Isovaleryl-CoA
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaR FPGS4m
kinetic law: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.3.2.17
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
name: folylpolyglutamate synthetase (DHF), mitochondrial
type: Reaction
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000000
reversible: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_524d664d_35b0_4133_aa86_138d806d0f42
is encoded by: hsa:251
type: Species
has only substance units: false
boundary condition: true
name: ALPPL2
is: SBO:0000252
initial concentration: NaN
is: P10696
initial amount: NaN
constant: false

metaM pan4p c
initial concentration: 1.0
initial amount: NaN
is: C01134
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
name: Pantetheine 4'-phosphate
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
constant: false

metaM docohexcoa m
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: 2,4,7,10,13,16-docosahexenoylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_24422919_cbc5_4ee8_a200_8542e70d7618
is encoded by: hsa:51166
name: AADAT
boundary condition: true
is: Q4W5N8
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM HC02210 c
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
is: CHEBI:34939
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
name: prostaglandin-d3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_76020c80_71e8_4c40_96cb_cd38ce1e6ce8
name: SMPD3
type: Species
is: Q9NY59
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55512
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM c226coa x
is: SBO:0000247
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
constant: false
is: C16169
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN

metaR ALCD21 L
name: alcohol dehydrogenase (L-1,2-propanediol)
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.24
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
is: SBO:0000176
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
product: MODEL1310110058#

metaR DM T antigen g
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_9156ccfc_4c0c_4aa0_9314_38b0eeb78411
boundary condition: true
has only substance units: false
is encoded by: hsa:8854
initial concentration: NaN
is: F5H2Y9
constant: false
is: SBO:0000252
type: Species
name: ALDH1A2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_4c83f91b_0baa_4931_a42b_c8d5560ae607
name: PDE6A
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: P16499
is encoded by: hsa:5145
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_7f96f32f_e9b6_41a1_b799_7c8b55045dce
is: Q9HBH5
initial concentration: NaN
name: RDH14
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:57665
type: Species
is: SBO:0000252
has only substance units: false

metaM 3aib D m
is: HMDB02299
initial amount: NaN
type: Species
is: C03265
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
initial concentration: 1.0
name: D-3-Amino-isobutanoate
boundary condition: false
has only substance units: false

metaM fad r
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01248
is: CHEBI:16238
has only substance units: false
boundary condition: false
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
type: Species

metaR BALAVECSEC
is described by: ECO:0000269
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (140679.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750892,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known for sure stoichiometrically, but 1:1 H coupling ratio is assumed, which could translate to 3 b-ala/ATP.
reversible: false
kinetic law: MODEL1310110058#
is: SBO:0000185
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
name: B-alanine secretion via secretory vesicle (ATP driven)

metaR SUCOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (GDP-forming)
type: Reaction
fast: false
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF

metaR r0650
kinetic law: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
reversible: true
fast: false
reactant: MODEL1310110058#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000

metaM 4abutn m
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
constant: false
name: 4-ammoniobutanal
type: Species
is: HMDB01080
is: CHEBI:58264
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_43aaf43d_2210_4c8e_b2c2_e06f54ed1310
initial concentration: NaN
type: Species
name: MGAM
is: O43451
is: SBO:0000252
constant: false
is encoded by: hsa:8972
has only substance units: false
boundary condition: true
initial amount: NaN

metaM fol e
boundary condition: false
is: HMDB00121
name: Folate
has only substance units: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_bb7534d8_ae31_43c3_931d_9ad7d2dbfb75
constant: false
has only substance units: false
is encoded by: hsa:55902
boundary condition: true
is: SBO:0000252
name: ACSS2
type: Species
initial amount: NaN
initial concentration: NaN
is: Q5QPH3

metaR r1917
product: MODEL1310110058#
is described by: ECO:0000000
modifier: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
type: Reaction
name: Y+LAT2 Utilized transport

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaR FAS80COA L
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110058#
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110058#
product: MODEL1310110058#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
kinetic law: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_53a5001e_0665_433f_be61_4152c4255dca
constant: false
is: SBO:0000252
is: P53396
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ACLY
has only substance units: false
is encoded by: hsa:47
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_fd149193_075f_46ae_b695_9f38fa08edfc
constant: false
initial concentration: NaN
is: SBO:0000252
name: LDHD
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:197257
is: Q86WU2

metaR r2471
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.18.8.1

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR r0653
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_dabb2124_6a94_4c4c_95a6_ba368367b4c1
has only substance units: false
is: P56556
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: NDUFA6
type: Species
boundary condition: true
constant: false
is encoded by: hsa:4700

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR LTD4DP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
name: Leukotriene D4 dipeptidase
reversible: true
is: SBO:0000176
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_279cdaeb_ede5_4f25_a3cb_a09f18a3908e
is encoded by: hsa:4708
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: H7C5B8
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: NDUFB2

http://identifiers.org/biomodels.db/MODEL1310110058#_dde9d43c_23df_42f3_8d6b_d81c8b7771da
is: Q99798
type: Species
initial concentration: NaN
name: ACO2
constant: false
is encoded by: hsa:50
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_293d842d_d0a6_449d_97d5_4cc4788f161d
name: SLC5A8
boundary condition: true
is encoded by: hsa:160728
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: Q8N695
is: SBO:0000252

metaM HC02210 e
is: CHEBI:34939
type: Species
name: prostaglandin-d3
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110058#_47c78c70_5912_4c6a_86e1_ce483239e02c
is encoded by: hsa:276
constant: false
boundary condition: true
type: Species
is: P04745
name: AMY1A
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM 34dhoxmand m
name: 3,4-Dihydroxymandelate
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:27637
is: HMDB01866
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580

http://identifiers.org/biomodels.db/MODEL1310110058#_58a2efc2_5490_4f1f_b82a_ed1a45dede7c
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6713
initial amount: NaN
name: SQLE
initial concentration: NaN
is: Q5HYI4
boundary condition: true

metaR r0652
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
type: Reaction
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110058#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_791c801b_1596_4fc8_8071_cad3437916b9
type: Species
is: O00400
initial amount: NaN
is encoded by: hsa:9197
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: SLC33A1

metaR EHGLAT2m
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000304
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial

metaR r1915
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110058#

metaR r0655
is described by: ECO:0000000
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_48e739f0_1143_4f73_a4e4_270693df9529
name: PLA2G4A
boundary condition: true
constant: false
is encoded by: hsa:5321
type: Species
initial concentration: NaN
is: P47712
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_cf4174a2_44df_4c5e_8b31_428f587e2050
is encoded by: hsa:6817
name: SULT1A1
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaR BILDGLCURtr
product: MODEL1310110058#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport
reversible: true
is described by: ECO:0000000

metaM fad m
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
type: Species
is: CHEBI:16238
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
is: C00016
is: HMDB01248
has only substance units: false

metaR ARGtm
modifier: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
name: arginine mitochondrial transport via ornithine carrier
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110058#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_91323eca_2de6_46b5_9767_79c189124adb
boundary condition: true
has only substance units: false
is: P36969
is encoded by: hsa:2879
name: GPX4
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_2b73a737_b6ee_4360_b0a7_c27a72615402
name: PIK3CB
constant: false
has only substance units: false
is encoded by: hsa:5291
is: SBO:0000252
is: B4DER4
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

metaM arg L e
boundary condition: false
name: L-argininium(1+)
has only substance units: false
is: HMDB00517
type: Species
is: CHEBI:32682
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

metaR ADSS
is described by: ECO:0000134
fast: false
modifier: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.3.4.4
reactant: MODEL1310110058#
name: adenylosuccinate synthase
type: Reaction
reversible: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277

metaM cholcoar x
constant: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: SBO:0000247
initial concentration: 1.0
is: HMDB02178
has only substance units: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
is: CHEBI:58677
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_886e5bfa_4dc2_46ea_a3f7_10c5a2b65143
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GLO1
type: Species
is: Q04760
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:2739

http://identifiers.org/biomodels.db/MODEL1310110058#_b9702a73_79ec_4105_935a_236e72144d35
name: ALAS1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: P13196
is encoded by: hsa:211
constant: false

metaR ACNAMPH
reactant: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110058#
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
fast: false
product: MODEL1310110058#
is described by: ECO:0000000

metaM guln c
is: SBO:0000247
is: HMDB03290
has only substance units: false
name: L-gulonate
constant: false
is: CHEBI:13115
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
boundary condition: false

metaM HC00250 c
is: CHEBI:29919
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: hydrosulfide

metaR NCNt
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110058#
reversible: true
fast: false
name: Na+/Ca2+-NH4+ exchange
reactant: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_82dd8162_e767_4ea5_a513_1e7a6132ec8c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1103
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: P28329
name: CHAT

metaM pep c
boundary condition: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial amount: NaN
has only substance units: false
name: Phosphoenolpyruvate
is: CHEBI:18021
is: C00074
initial concentration: 1.0
is: HMDB00263
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_0cc0bceb_186b_4092_9f1f_d9f848d7354f
boundary condition: true
is encoded by: hsa:2679
initial concentration: NaN
name: GGT3P
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaM c16dc c
is: HMDB00712
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
name: Hexadecanedioic acid mono-L-carnitine ester
initial concentration: 1.0
notes: FORMULA: C23H42NO6 CHARGE: -1
constant: false
is: SBO:0000247

metaR URIt
reversible: true
modifier: MODEL1310110058#
is: SBO:0000185
name: uridine facilated transport in cytosol
reactant: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR GHMT2r
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.1
type: Reaction
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000269
product: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
name: glycine hydroxymethyltransferase, reversible

metaM HC01412 m
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
name: trans-tetradec-2-enoyl-CoA(4-)
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61405
boundary condition: false

metaM thcholstoic m
is: CHEBI:18402
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_3624a54c_6098_4e90_8a60_e438645c5016
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3418
name: IDH2
is: P48735
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM arg L c
type: Species
is: CHEBI:32682
is: HMDB00517
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)

http://identifiers.org/biomodels.db/MODEL1310110058#_8f438ded_cb21_48e8_91a7_4b3e78db3464
has only substance units: false
initial amount: NaN
name: SLC25A26
type: Species
constant: false
is encoded by: hsa:115286
boundary condition: true
is: F8WAB8
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_6ffdde52_8546_4bc5_8c3d_04600eee6182
has only substance units: false
name: CA1
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:759
boundary condition: true
initial amount: NaN
is: P00915
constant: false

metaM ascb L e
is: SBO:0000247
initial amount: NaN
name: L-ascorbate
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
type: Species
boundary condition: false
is: CHEBI:38290
constant: false
has only substance units: false
initial concentration: 1.0

metaM HC01522 c
is: CHEBI:28508
initial amount: NaN
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
name: Gentisate aldehyde
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r0656
reversible: false
is: SBO:0000176
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
fast: false
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:

metaR EX ddece1crn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_6585d0af_cadb_4129_9d3c_29c6703de8a1
is: Q92523
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1375
initial concentration: NaN
name: CPT1B
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_2f9e7668_50a5_4f0a_84d1_6c0bcd12d834
initial amount: NaN
is encoded by: hsa:2592
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: GALT
boundary condition: true
is: B2RAT6

http://identifiers.org/biomodels.db/MODEL1310110058#_720d3017_73cf_4cfc_9554_7f66adf393a7
is: O75438
initial amount: NaN
is encoded by: hsa:4707
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: NDUFB1
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_bc161ce2_5e50_490f_a4d2_7c7aa7036b0a
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10005
is: O14734
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: ACOT8
constant: false

metaR C81CPT1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

metaR DNDPt29m
fast: false
kinetic law: MODEL1310110058#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110058#
reactant: MODEL1310110058#
name: dCDP transport via dADP antiport
reversible: false
modifier: MODEL1310110058#

metaM HC00250 e
name: hydrosulfide
constant: false
is: CHEBI:29919
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR GLYt7 311 r
fast: false
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
modifier: MODEL1310110058#
is described by: ECO:0000006
name: glycine reversible transport via sodium and chloride symport (3:1:1)
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_46d848cb_c79a_470f_929f_4d71c70252a1
initial concentration: NaN
is: Q5JWV8
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2182
name: ACSL4
constant: false

metaR r2197
product: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM glyald m
initial concentration: 1.0
initial amount: NaN
name: D-glyceraldehyde
type: Species
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
is: HMDB01051
constant: false
boundary condition: false
is: CHEBI:17378

http://identifiers.org/biomodels.db/MODEL1310110058#_85f6b0a4_de92_4069_b9cf_9dd43ee76e4f
is encoded by: hsa:4891
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: SLC11A2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: B4DK84

http://identifiers.org/biomodels.db/MODEL1310110058#_05aedc88_27b7_470b_aa59_7bfa455d4b4f
has only substance units: false
is: Q92536
is: SBO:0000252
type: Species
name: SLC7A6
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:9057
initial concentration: NaN

metaM ascb L c
is: CHEBI:38290
type: Species
constant: false
name: L-ascorbate
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00044
initial amount: NaN

metaR biomass reaction
reversible: false
reactant: MODEL1310110058#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
name: Generic human biomass reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#

metaR B MANNASEly
name: beta-mannosidase, lysosomal
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.25
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
modifier: MODEL1310110058#
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_898e2c9c_11e0_4df9_bd8f_3fef537cc5b3
is encoded by: hsa:223
is: SBO:0000252
boundary condition: true
name: ALDH9A1
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: P49189
initial concentration: NaN

metaM 4abutn c
is: C00555
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01080
is: CHEBI:58264
type: Species
name: 4-Aminobutanal
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_f5428942_b037_47ed_93c8_95aa384187ec
name: PLA2G6
type: Species
is encoded by: hsa:8398
is: A8K460
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r2198
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#

metaR CLOXAtex2
fast: false
type: Reaction
product: MODEL1310110058#
name: chloride transport via oxalate countertransport (2:1)
is described by: ECO:0000304
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_bf30fc69_7d98_41ea_89f0_4d89fcd159d9
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is: P22303
is encoded by: hsa:43
name: ACHE

http://identifiers.org/biomodels.db/MODEL1310110058#_418fb23e_4368_413d_8dec_af2d323948ff
boundary condition: true
initial amount: NaN
is: Q9HBU6
type: Species
constant: false
is: SBO:0000252
name: ETNK1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55500

http://identifiers.org/biomodels.db/MODEL1310110058#_1abfbe9a_a303_4a57_9b84_0e2b1986f92e
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: B7Z4Y6
is encoded by: hsa:249
is: SBO:0000252
name: ALPL
has only substance units: false
type: Species
constant: false

metaM C05957 r
initial concentration: 1.0
name: Prostaglandin J2
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB02710
is: CHEBI:27485
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: SBO:0000247

metaM pe hs m
is: CHEBI:16038
initial concentration: 1.0
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

metaR r0210
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 0 AUTHORS: PMID:681363 NOTES:
fast: false
kinetic law: MODEL1310110058#
name: L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_0d841dec_705e_4744_8ad7_f598e70c0dbf
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:522
is: SBO:0000252
name: ATP5J
is: Q6NZ59
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_a4598766_88d6_4d6b_a5a0_dac0b7ba8d0f
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q8N1Q1
type: Species
boundary condition: true
name: CA13
constant: false
is encoded by: hsa:377677
is: SBO:0000252

metaR r0870
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/3.1.3.4
reactant: MODEL1310110058#
reversible: true
is: SBO:0000185
modifier: MODEL1310110058#
name: Facilitated diffusion
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.72

metaR r2199
type: Reaction
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
fast: false

metaM mpdol L c
initial amount: NaN
has only substance units: false
is: CHEBI:18396
constant: false
boundary condition: false
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR 4HPROLTASCT1
reversible: false
fast: false
product: MODEL1310110058#
is: SBO:0000185
type: Reaction
name: exit of hydroxy-prloine across the basolateral surface of enterocytes
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 17475673. NOTES:ASCT1 helps in absorption of hydroxy-proline by aiding in its exit from the enterocytes into the blood stream. The ASCT1 transport system operates as an obligatory amino acid exchanger, Na+ depedant manner. Alaine is the preeferred susbstrate.
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000134
kinetic law: MODEL1310110058#

metaR BHBt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate transport via H+ symport
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_e43a42a0_d059_40b0_ba3e_4738672ff01a
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:517
name: ATP5G2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_8e5f2ae1_9384_488e_9a38_fef24eaa9d60
is: P15291
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:2683
name: B4GALT1
initial concentration: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ed03f71b_a922_491a_9d3f_aa5855a4091b
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O95168
type: Species
is encoded by: hsa:4710
name: NDUFB4
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_53e944d8_599a_4581_81b2_77ed7b63994b
is encoded by: hsa:171425
is: Q8N0X4
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: CLYBL
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_796333d8_3bf9_4416_aa08_bed28e308407
constant: false
boundary condition: true
has only substance units: false
name: SUCLG2
is encoded by: hsa:8801
is: Q96I99
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaR FATP2t
name: fatty acid electroneutral transport
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
fast: false

metaM CE5119 m
is: CHEBI:57923
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
constant: false
type: Species
name: trans-3-cis-8-tetradecadienoyl-CoA
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM 4abutn e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
is: HMDB01080
has only substance units: false
is: CHEBI:58264
name: 4-ammoniobutanal
constant: false
type: Species

metaM c226coa m
constant: false
is: http://identifiers.org/pubchem.compound/47205479
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
is: SBO:0000247
is: C16169
has only substance units: false
type: Species
boundary condition: false

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM 2dr5p c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01031
boundary condition: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: CHEBI:57651
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673

metaM c101crn c
name: decenoyl carnitine
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C17H31NO4 CHARGE: 0
constant: false
has only substance units: false
is: HMDB13205

metaR NRPPHRSFt
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000185
name: norepinephrine sulfate transport (diffusion)
is described by: ECO:0000000
reversible: false
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB

metaR FAOXC183806m
is described by: ECO:0000269
is: SBO:0000176
reversible: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110058#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_46749d34_e651_468b_a0f2_aa5af09aa54c
is: P31639
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6524
name: SLC5A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_f4fc3a86_bffd_4c78_bc89_8de6f07f4378
is: SBO:0000252
constant: false
is encoded by: hsa:4722
initial concentration: NaN
is: O75489
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: NDUFS3

http://identifiers.org/biomodels.db/MODEL1310110058#_cc04cc26_b6a7_4b8a_82f5_190cca911dab
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: B2RD24
name: MTHFD1L
is encoded by: hsa:25902
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_32ca769f_c20f_463b_a98c_1343534d41b0
type: Species
constant: false
is: Q92835
has only substance units: false
name: INPP5D
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3635
is: SBO:0000252
boundary condition: true

metaM pe hs r
is: SBO:0000247
is: CHEBI:16038
has only substance units: false
type: Species
name: phosphatidylethanolamine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false

metaM C02528 r
has only substance units: false
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
is: HMDB00518
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:36234
initial concentration: 1.0
type: Species

metaR ADSK
reactant: MODEL1310110058#
reversible: false
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is: SBO:0000176
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110058#
name: adenylyl-sulfate kinase
product: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_3a7d1f2d_ceff_469e_a69d_33707b99c7d1
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: CHDH
has only substance units: false
is: Q8NE62
is encoded by: hsa:55349

metaM 5forthf c
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
constant: false
initial concentration: 1.0
is: CHEBI:57456
is: HMDB01534
is: SBO:0000247
type: Species
name: 5-Formiminotetrahydrofolate
boundary condition: false
is: C00664
initial amount: NaN
has only substance units: false

metaR GGT5r
reversible: true
fast: false
name: Gamma-glutamyltransferase 5
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
modifier: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
is described by: ECO:0000134

metaR G14T9g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110058#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000

metaR FAOXC81C61m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaM ala B c
is: CHEBI:16958
name: beta-alanine
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00056
has only substance units: false

metaM xoldioloneh c
has only substance units: false
constant: false
is: HMDB06887
is: SBO:0000247
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:2288

http://identifiers.org/biomodels.db/MODEL1310110058#_d2b11d01_2e9f_4a19_9621_8265c9709434
has only substance units: false
type: Species
is encoded by: hsa:5337
name: PLD1
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q59EA4

http://identifiers.org/biomodels.db/MODEL1310110058#_cdbfd449_4ac3_49a5_8654_c673567e6ffd
name: GLUD2
is encoded by: hsa:2747
initial amount: NaN
boundary condition: true
is: P49448
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR SPHS1Pte
product: MODEL1310110058#
type: Reaction
name: sphingosine-1-phosphate transport
kinetic law: MODEL1310110058#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ

metaM dtmp m
is: SBO:0000247
is: C00364
boundary condition: false
name: dTMP
type: Species
is: CHEBI:26999
initial concentration: 1.0
is: HMDB01227
has only substance units: false
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_c1b24018_f398_46f8_bfa3_4f647481ec0d
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ALDOA
constant: false
is encoded by: hsa:226
has only substance units: false

metaM c101crn e
constant: false
boundary condition: false
is: HMDB13205
has only substance units: false
initial concentration: 1.0
type: Species
name: decenoyl carnitine
notes: FORMULA: C17H31NO4 CHARGE: 0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_8a881189_d142_4a3d_bbf3_c44f20ac0696
is: F5H6D0
initial concentration: NaN
type: Species
boundary condition: true
name: MOGS
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:7841
is: SBO:0000252

metaM 3sala c
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
boundary condition: false
type: Species
is: C00606
initial amount: NaN
has only substance units: false
name: 3-Sulfino-L-alanine
constant: false
initial concentration: 1.0
is: CHEBI:61085
is: SBO:0000247

metaM arg L m
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
is: HMDB00517
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-argininium(1+)
is: CHEBI:32682
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_6d4ed9ea_82fd_4061_9001_bbf626882853
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:221
initial amount: NaN
is: P43353
constant: false
type: Species
has only substance units: false
boundary condition: true
name: ALDH3B1

metaM pan4p e
name: Pantetheine 4'-phosphate
constant: false
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C01134
type: Species
is: SBO:0000247
is: HMDB01416
has only substance units: false

metaR CSm
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
name: citrate synthase
fast: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.3.1
modifier: MODEL1310110058#

metaR FAS180COA
reactant: MODEL1310110058#
name: fatty-acyl-CoA synthase (n-C18:0CoA)
kinetic law: MODEL1310110058#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269

metaR ALASERNaEx
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is: SBO:0000185
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
fast: false
reactant: MODEL1310110058#

metaM lnlccoa m
boundary condition: false
name: linoleic coenzyme A
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false

metaR GLYt7 211 r
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110058#
type: Reaction
fast: false
product: MODEL1310110058#
reversible: true
name: glycine reversible transport via sodium and chloride symport (2:1:1)
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#

metaM ala B e
is: CHEBI:16958
constant: false
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN
is: SBO:0000247
name: beta-alanine
boundary condition: false
is: HMDB00056
type: Species
initial concentration: 1.0

metaR FAOXC102C101m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM 4hexdtricoa m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
name: 4,7,10-hexadecatrienoylcoa
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02288
type: Species

metaR r2309
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false

metaR PTDCACRNt
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
name: pentadecanoate transport into the mitochondria
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_8807a07f_4329_4700_abbb_e2caf1cc8879
is encoded by: hsa:954
boundary condition: true
initial concentration: NaN
is: Q5SPY7
is: SBO:0000252
initial amount: NaN
name: ENTPD2
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_c3c7fd74_60ce_4859_847c_547ff87e7dbd
has only substance units: false
is: SBO:0000252
is: O15121
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:8560
constant: false
initial concentration: NaN
name: DEGS1

metaM clpnd c
type: Species
boundary condition: false
is: CHEBI:53488
is: HMDB06528
name: clupanodonic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR NTD5
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110058#
name: 5'-nucleotidase (dTMP)
modifier: MODEL1310110058#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_7faf3b9a_167c_40b3_bea4_c2750fa5cf76
boundary condition: true
type: Species
is encoded by: hsa:7298
constant: false
has only substance units: false
initial amount: NaN
is: P04818
name: TYMS
is: SBO:0000252
initial concentration: NaN

metaM dgmp e
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial amount: NaN
is: CHEBI:57673
initial concentration: 1.0
type: Species
name: dGMP(2-)
boundary condition: false

metaM mi13p c
is: SBO:0000247
type: Species
is: HMDB06234
boundary condition: false
has only substance units: false
name: 1D-myo-Inositol 1,3-bisphosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
is: CHEBI:18225
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_bd2702e5_37f5_4b80_9b05_72f4fc4af14c
is: P48448
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:222
type: Species
name: ALDH3B2
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_78fc4ece_8d2e_4ada_a727_c48da3ec9300
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:516
name: ATP5G1
has only substance units: false
is: Q6FIH7
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_afc5b8b8_f656_4363_ba1c_8b41c4e9c534
is encoded by: hsa:65010
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: SLC26A6
constant: false
is: Q9NQU1
initial amount: NaN
boundary condition: true

metaR TETDEC2CRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR LEUKTRB4t
name: leukotriene B4 transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_c583fb9c_faa9_4f2e_a8b7_cf1054dd02f0
is encoded by: hsa:115584
name: SLC5A11
initial concentration: NaN
type: Species
is: Q8WWX8
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR GLUTCOADHm
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.99.7
is: SBO:0000176
name: glutaryl-CoA dehydrogenase (mitochondria)
fast: false
reversible: false
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_36ea72cf_cd6d_45b3_9cdf_d9803c9adba7
is: O15254
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: ACOX3
initial concentration: NaN
is encoded by: hsa:8310

metaR CLPNDt
is: SBO:0000185
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110058#
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaM n2m2nmn l
notes: FORMULA: C50H84N4O36 CHARGE: 0
boundary condition: false
is: HMDB00742
has only substance units: false
initial concentration: 1.0
is: CHEBI:17588
type: Species
constant: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_2383f8e0_ae20_46a0_957f_431c736e3b31
initial concentration: NaN
initial amount: NaN
is: Q9NS18
boundary condition: true
has only substance units: false
is encoded by: hsa:51022
type: Species
constant: false
is: SBO:0000252
name: GLRX2

metaR UPPN
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: false
type: Reaction
modifier: MODEL1310110058#
is described by: ECO:0000269
name: b-ureidopropionase
is version of: http://identifiers.org/ec-code/3.5.1.6
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_f3c6ca27_44a7_4339_bde1_529bbe0fc529
initial concentration: NaN
initial amount: NaN
constant: false
name: _LOC374569_1_e
is encoded by: hsa:LOC374569
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_e89bc301_2976_4c36_b877_416306f8b6f3
name: B3GALNT1
type: Species
is encoded by: hsa:8706
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: B3KTQ4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_84a516d2_2c17_4acc_9e91_fcb440108e93
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: NMNAT3
is encoded by: hsa:349565
is: Q96T66
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_d84ec862_9366_4d49_93e0_d6256287482f
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110058#_0a371738_4bb3_456c_bf97_0b9516d6ab85
is encoded by: hsa:AV713053
has only substance units: false
type: Species
name: _AV713053_1_m
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_6de46473_8e31_4fc8_813b_df57768df471
type: Species
is: SBO:0000252
is encoded by: hsa:6526
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: P53794
name: SLC5A3
has only substance units: false

metaR NTD8
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110058#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
reactant: MODEL1310110058#
type: Reaction
fast: false
name: 5'-nucleotidase (dGMP)
product: MODEL1310110058#
modifier: MODEL1310110058#

metaR CYSGLUexR
kinetic law: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
fast: false
name: L-cysteine/L-glutamine reversible exchanger

metaM CE5101 m
type: Species
is: CHEBI:57795
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
has only substance units: false
is: SBO:0000247
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaM CE4792 m
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
name: 3-oxo-cis-8-tetradecenoyl-CoA
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:57923
initial concentration: 1.0

metaR PPItm
type: Reaction
name: diphopshate transporter, mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
reversible: true
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
is described by: ECO:0000134
kinetic law: MODEL1310110058#

metaM dgmp c
is: SBO:0000247
name: dGMP
constant: false
is: HMDB01044
is: C00362
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57673
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
type: Species
boundary condition: false

metaR FAOXC102C81m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR GULNter
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: L-gulonate endoplasmic reticular export
fast: false
is: SBO:0000185

metaR r2308
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_5d06d3e3_b9ae_4f46_89b8_5a6b994c2497
is: SBO:0000252
name: CA8
constant: false
initial amount: NaN
is: P35219
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:767

metaM udpglcur r
has only substance units: false
type: Species
name: UDP-D-glucuronate
is: CHEBI:58052
is: HMDB00935
is: C00167
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167

http://identifiers.org/biomodels.db/MODEL1310110058#_fe2891a5_6ae5_4047_ac23_78e9d5d7e4d5
boundary condition: true
constant: false
is encoded by: hsa:10841
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: FTCD
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_81757e4b_6213_4b5a_a5eb_1932c9bdcc3e
is: SBO:0000252
has only substance units: false
is: O95167
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:4696
name: NDUFA3
initial amount: NaN

metaR r2047
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_795c3111_a54a_491f_a1ee_7b9c7c120ca8
is: Q9NPH0
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51205
has only substance units: false
name: ACP6

http://identifiers.org/biomodels.db/MODEL1310110058#_bdb83bae_32bc_4002_92a6_1d0fd7be6adf
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q7L266
initial amount: NaN
constant: false
name: ASRGL1
type: Species
is encoded by: hsa:80150

http://identifiers.org/biomodels.db/MODEL1310110058#_ef0637b3_dd9b_408f_8c75_22c5c9a54469
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q674R7
has only substance units: false
name: ATG9B
boundary condition: true
is encoded by: hsa:285973
type: Species
initial amount: NaN

metaM ksi pre33 g
is: HMDB00175
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00130
name: keratan sulfate I biosynthesis, precursor 33
boundary condition: false
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
has only substance units: false
is: SBO:0000247
is: CHEBI:58053
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_49dcb43e_e0a0_445f_bbc1_69ab8eb226fc
type: Species
is: SBO:0000252
is encoded by: hsa:1109
has only substance units: false
is: P17516
boundary condition: true
initial concentration: NaN
name: AKR1C4
constant: false
initial amount: NaN

metaM c226coa c
constant: false
is: C16169
name: cervonyl coenzyme A
has only substance units: false
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_a85cc9f5_32a2_499c_a2d8_f905a4fe44aa
name: DAD1
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is: Q53G02
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1603

http://identifiers.org/biomodels.db/MODEL1310110058#_2f392672_1e4f_44ff_8b6b_a4a5145cb5a6
has only substance units: false
type: Species
name: HSD3B2
is: P26439
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3284
boundary condition: true
constant: false

metaM dtmp c
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01227
is: C00364
is: SBO:0000247
name: dTMP
constant: false
is: CHEBI:26999
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_3e98b7bf_bea9_4477_b043_3d73e4f99dea
is encoded by: hsa:30833
name: NT5C
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q8TCD5

metaR AACOAT
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
name: Acetoacetyl-CoA:acetate CoA-transferase
fast: false
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.16

http://identifiers.org/biomodels.db/MODEL1310110058#_4a2781ff_e8a6_472a_ac1c_0206479e453b
name: FASN
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P49327
constant: false
type: Species
is encoded by: hsa:2194

metaR RE0958E
is described by: ECO:0000000
name: RE0958
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1

metaR CYSATB0tc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the intestinal cells by ATB0 transporter
type: Reaction

metaR 3SPYRSPm
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_e415e4d7_9674_4c37_bd7e_9529e7f6ca88
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: O75355
name: ENTPD3
is: SBO:0000252
is encoded by: hsa:956
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_c31758d2_77e4_4438_ba3f_7aca49ef783e
initial amount: NaN
has part: P08559
is: SBO:0000297
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5160
initial concentration: NaN
name: DLAT:DLD:PDHA1:PDHB:PDHX
boundary condition: true

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaM acgal l
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00212
is: CHEBI:28037
type: Species
name: N-acetyl-D-galactosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_cca6c17b_3edc_47a0_8968_f2076c3ef1e6
initial amount: NaN
name: ACOX1
is encoded by: hsa:51
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: B4DK61
type: Species

metaR LEUTA
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
reactant: MODEL1310110058#
fast: false
type: Reaction
name: leucine transaminase
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000176

metaM pan4p m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
type: Species
has only substance units: false
name: pantetheine 4'-phosphate(2-)
is: CHEBI:47942
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_4c4976a5_1e5b_4684_a5dd_2a4cc88b4e0a
is encoded by: hsa:8525
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: G3V0F6
constant: false
initial amount: NaN
name: DGKZ
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_ec56fb17_f6c4_409b_aae4_c8edd7ec0a53
initial concentration: NaN
is encoded by: hsa:127
has only substance units: false
is: P08319
name: ADH4
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_02b3ac58_7331_45d4_a860_686302cb7ccd
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8836
is: Q92820
name: GGH
constant: false
type: Species

metaR r0539
is: SBO:0000176
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.34
fast: false
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
reactant: MODEL1310110058#
reversible: true

metaR CYSTGL
is: SBO:0000176
name: cystathionine g-lyase
is version of: http://identifiers.org/ec-code/4.4.1.1
product: MODEL1310110058#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:10727430,PMID:15189131 NOTES:NCD
type: Reaction
modifier: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: false

metaM dtmp e
is: CHEBI:26999
initial amount: NaN
name: dTMP(2-)
is: HMDB01227
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaM xmp c
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
name: Xanthosine 5'-phosphate
type: Species
initial concentration: 1.0
is: HMDB01554
is: SBO:0000247
constant: false
is: C00655
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57464

metaM clpnd e
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB06528
is: CHEBI:53488
boundary condition: false
name: clupanodonic acid
initial amount: NaN
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
constant: false

metaM CE5854 e
is: HMDB02710
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:27485
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
name: gama-CEHC-glucuronide

metaR CYTK12n
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
is: SBO:0000176
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: cytidylate kinase (dCMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_b75af17b_e0a7_4939_ac13_4acf762877e0
is encoded by: hsa:3032
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: HADHB
boundary condition: true
is: P55084

http://identifiers.org/biomodels.db/MODEL1310110058#_54ccc77b_0be2_4f7f_b0e9_b14d94901561
constant: false
initial amount: NaN
is: Q13907
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: IDI1
has only substance units: false
is encoded by: hsa:3422

metaR ARGLYSex
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reversible: false
fast: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110058#
name: Arginine/Lysine exchanger (Arg in)
product: MODEL1310110058#

metaR BAMPPALDOX
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110058#
is described by: ECO:0000212
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
type: Reaction
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_9971f99d_3375_42e3_9a3e_6dc7680c7716
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: _AI824319_1_r
type: Species
is encoded by: hsa:AI824319
has only substance units: false
initial concentration: NaN

metaR PPItr
is: SBO:0000185
fast: false
name: Diphosphate transporter, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR CYSO
name: cysteine oxidase
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.13.11.20
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is described by: ECO:0000269

metaR PIK3
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000176
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.137
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_f197ef99_8e33_4800_9191_30669cd156e4
is: SBO:0000252
type: Species
is: B2R6S5
is encoded by: hsa:51727
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: CMPK1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_d808d2f0_6742_4554_aa07_75f07196fcb2
name: PIK3R1
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: P27986
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5295
type: Species

metaM man6p c
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
type: Species
initial amount: NaN
name: D-Mannose 6-phosphate
is: CHEBI:17369
is: HMDB01078
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR DTDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
name: dTDP nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110058#_5cb6b305_60b1_432b_ac79_e0337165419f
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:BE966236
is: SBO:0000252
name: _BE966236_1_c
type: Species

metaR FAOXC201C181x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_c04d9b8a_3443_472d_b74e_3659538941a0
is: Q6IBA0
boundary condition: true
type: Species
initial amount: NaN
name: NDUFS5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4725
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_389161f6_43b0_4604_962e_28be755e12b9
has only substance units: false
name: AKR1B1
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:231
is: P15121
is: SBO:0000252
initial amount: NaN

metaR r0559
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
type: Reaction
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true

metaM ha pre1 l
type: Species
is: SBO:0000247
constant: false
boundary condition: false
name: hyaluronan biosynthesis, precursor 1
initial concentration: 1.0
is: CHEBI:16126
has only substance units: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR RE3628M
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: RE3628
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaM CE5236 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
is: HMDB03952
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28002
type: Species

metaM dadp c
name: dADP
initial concentration: 1.0
is: CHEBI:57667
is: HMDB01508
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
boundary condition: false
is: C00206

http://identifiers.org/biomodels.db/MODEL1310110058#_ab2b52f2_71b7_44d4_adc4_f3c87702b617
type: Species
boundary condition: true
constant: false
is: P09417
is encoded by: hsa:5860
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: QDPR
has only substance units: false

metaR B3GALT5g
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
is described by: ECO:0000269
modifier: MODEL1310110058#
name: Beta-1,3-galactosyltransferase 5
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR DNDPt17m
product: MODEL1310110058#
reactant: MODEL1310110058#
name: dUDP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
reversible: false
type: Reaction

metaM 5aop m
is: C00430
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:17549
type: Species
constant: false
is: HMDB01149
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: SBO:0000247
name: 5-Amino-4-oxopentanoate
has only substance units: false

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_01a638a7_d698_4444_9dfe_d6b1152700ab
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AI539321_1_c
type: Species
constant: false
boundary condition: true
is encoded by: hsa:AI539321

http://identifiers.org/biomodels.db/MODEL1310110058#_7a33afd3_be13_483c_97ef_74e4f59ad225
initial amount: NaN
is encoded by: hsa:4729
type: Species
is: P19404
boundary condition: true
is: SBO:0000252
name: NDUFV2
initial concentration: NaN
constant: false
has only substance units: false

metaR r0558
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
modifier: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_f3fe521b_e925_419f_b230_9a38101d0045
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:7372
is: A8K5J1
name: UMPS
boundary condition: true
has only substance units: false

metaM HC01407 m
name: (S)-Hydroxyhexanoyl-CoA
constant: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:28276

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM nrpphrsf c
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/123747
is: HMDB02062
name: Sulfate derivative of norepinephrine
type: Species
constant: false
has only substance units: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_46bd897e_9be6_48c6_b511_85b1dca6068c
boundary condition: true
initial amount: NaN
name: ENTPD1
initial concentration: NaN
is: Q86VV3
is encoded by: hsa:953
has only substance units: false
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_262455d9_b416_4703_be38_c02fa4894c4d
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: UPP1
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:7378

metaM c8dc x
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00893
notes: FORMULA: C15H26NO6 CHARGE: -1
type: Species
boundary condition: false
name: suberyl carnitine
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_28b1d6a9_bff7_4799_9cef_ce1e0b37dc00
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: SDR16C5
is encoded by: hsa:195814
has only substance units: false
initial amount: NaN
is: B3KT84

metaR FAOXC221C201x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b30205e6_0d1a_46f7_bd25_2dad473ad907
has only substance units: false
initial amount: NaN
is encoded by: hsa:2678
boundary condition: true
name: GGT1
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR CHLPCTD
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.15
name: choline phosphate cytididyltransferase
modifier: MODEL1310110058#
type: Reaction
reversible: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269

metaM mi1345p c
is: HMDB01059
type: Species
initial concentration: 1.0
is: CHEBI:57895
initial amount: NaN
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272

metaR r0661
reactant: MODEL1310110058#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110058#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110058#
is described by: ECO:0000000

metaM 2dr1p c
is: SBO:0000247
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
constant: false
is: HMDB01351
has only substance units: false
is: C00672
boundary condition: false
initial concentration: 1.0
is: CHEBI:58576

http://identifiers.org/biomodels.db/MODEL1310110058#_ea8facf1_d999_4a0c_a85c_ca05607831a8
is encoded by: hsa:518
type: Species
constant: false
is: SBO:0000297
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2

metaR FPGS5m
modifier: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
name: folylpolyglutamate synthetase (DHF), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.3.2.17
type: Reaction

metaR r0556
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.19.1
modifier: MODEL1310110058#
is: SBO:0000176
fast: false

metaM malcoa e
is: HMDB01175
name: malonyl-CoA(4-)
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: SBO:0000247
is: CHEBI:57384

metaM crm hs c
name: N-acylsphingosine
is: CHEBI:52639
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
boundary condition: false

metaM cs a deg4 l
initial concentration: 1.0
is: HMDB01354
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H49NO29S CHARGE: -2
boundary condition: false
is: CHEBI:57455
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_19a7dc87_c02e_4271_8e20_209caf3f063e
is encoded by: hsa:113452
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: TMEM54
initial amount: NaN
is: Q969K7
type: Species
constant: false
boundary condition: true

metaR DTTPtn
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
name: dTTP diffusion in nucleus
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR FMNAT
fast: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: FMN adenylyltransferase
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
product: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.7.2
is: SBO:0000176
reversible: false
is described by: ECO:0000134
type: Reaction

metaM 4hphac e
is: HMDB00020
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:48999
initial concentration: 1.0
name: 4-hydroxyphenylacetate
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642

http://identifiers.org/biomodels.db/MODEL1310110058#_f95e2fb4_43e1_4e92_a729_9cb94237061d
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:10768
name: AHCYL1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: O43865

metaM xtsn c
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:18107
name: xanthosine
is: HMDB00299
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
type: Species
has only substance units: false

metaR r0331
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is: SBO:0000176
reactant: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
modifier: MODEL1310110058#
is described by: ECO:0000000
reversible: false

metaR G5SADrm
kinetic law: MODEL1310110058#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is: SBO:0000176
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD

http://identifiers.org/biomodels.db/MODEL1310110058#_d6f218b3_3328_4bff_bffa_9eff17741df9
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:6487
name: ST3GAL3
initial amount: NaN
is: B4DX62

metaR r0660
fast: false
reversible: true
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_0567828b_c68c_4485_8b02_2e5f9df82f2a
initial concentration: NaN
boundary condition: true
type: Species
name: FUT8
constant: false
initial amount: NaN
has only substance units: false
is: Q546E0
is: SBO:0000252
is encoded by: hsa:2530

http://identifiers.org/biomodels.db/MODEL1310110058#_022459f0_cb58_4bb9_a92f_837c77de48b2
boundary condition: true
has only substance units: false
is encoded by: hsa:5286
type: Species
name: PIK3C2A
is: SBO:0000252
is: O00443
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_919d27c2_3d1c_427a_a21b_7bbba667950a
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC25A19
is: Q9HC21
is encoded by: hsa:60386

metaR DALAt2r
name: D-alanine transport via proton symport
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000304
modifier: MODEL1310110058#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR

metaR r1801
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
is described by: ECO:0000000
modifier: MODEL1310110058#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_403b6d50_4ee2_41df_bda4_491db659fec0
is encoded by: hsa:1339
has part: Q7GXY8
has part: Q7GXZ8
constant: false
initial concentration: NaN
is encoded by: hsa:4512
is encoded by: hsa:1337
has part: P24311
has part: P09669
has part: Q02221
has only substance units: false
is encoded by: hsa:4514
has part: Q96KJ9
has part: H0UI06
is encoded by: hsa:9167
is encoded by: hsa:1345
has part: P13073
has part: Q7Z4L0
has part: P12074
has part: P15954
is encoded by: hsa:341947
is encoded by: hsa:84701
has part: Q53XN1
has part: Q53YB7
is encoded by: hsa:1347
has part: P00414
is encoded by: hsa:170712
has part: Q6FGA0
has part: P14854
is encoded by: hsa:4513
is encoded by: hsa:1351
is encoded by: hsa:9377
is encoded by: hsa:125965
is encoded by: hsa:1327
is: SBO:0000297
is encoded by: hsa:1349
initial amount: NaN
has part: P20674
is encoded by: hsa:1350
has part: P24310
is encoded by: hsa:1329
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1340
has part: Q8TF08
is encoded by: hsa:1346
type: Species
boundary condition: true
has part: Q6YFQ2

http://identifiers.org/biomodels.db/MODEL1310110058#_90575cc3_ff19_47e7_aa63_2cad3e7f0c61
is encoded by: hsa:1808
is: SBO:0000252
initial amount: NaN
is: B4DR31
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: DPYSL2
boundary condition: true

metaR FACOAL191
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000269
reversible: false
product: MODEL1310110058#
name: fatty-acid--CoA ligase
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_2f7a65d5_bec3_40ca_9f34_6c21507c9890
initial amount: NaN
name: CNDP1
is encoded by: hsa:84735
type: Species
initial concentration: NaN
is: Q96KN2
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaM succoa x
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Succinyl-CoA
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial amount: NaN
constant: false
is: HMDB01022

metaM crm hs e
initial concentration: 1.0
type: Species
name: N-acylsphingosine
has only substance units: false
initial amount: NaN
is: CHEBI:52639
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_778d9889_e071_4e79_a445_25ce1138f3aa
type: Species
is: P22352
is encoded by: hsa:2878
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: GPX3

metaR DGCHOLte
name: bile acid intracellular transport
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true

metaR PRODt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
reversible: true
name: D-proline reversible transport via proton symport
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000304
fast: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_537d2e11_d029_43a5_bbc5_b794cf20b92c
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:594
boundary condition: true
type: Species
name: BCKDHB
initial amount: NaN
is: P21953
is: SBO:0000252

metaM 4hphac c
is: HMDB00020
boundary condition: false
initial amount: NaN
is: CHEBI:48999
constant: false
initial concentration: 1.0
name: 4-hydroxyphenylacetate
has only substance units: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
type: Species
is: SBO:0000247

metaR GDPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110058#
type: Reaction
name: GDP intracellular transport
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#

metaR RE1527M
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110058#
reversible: true
name: RE1527

metaM 5thf e
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C39H45N11O18 CHARGE: -6
initial amount: NaN
initial concentration: 1.0
name: pentaglutamyl folate (THF)
is: HMDB06487

metaM c51crn c
is: SBO:0000247
initial amount: NaN
is: HMDB02366
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C12H21NO4 CHARGE: 0
type: Species
name: tiglyl carnitine

metaM CE0785 m
constant: false
name: cis,cis-myristo-5,8-dienoyl-CoA
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
has only substance units: false
is: CHEBI:57795
initial amount: NaN
is: SBO:0000247

metaR CYSALANaEx
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000269
reversible: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110058#

metaR ANTHte
reversible: true
name: Transport of anthranilate
type: Reaction
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#

metaR r0553
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: true
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
type: Reaction
fast: false
product: MODEL1310110058#
is: SBO:0000176

metaR FAOXC184C163m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaR C4tcx
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM ksii core2 pre7 g
is: CHEBI:58053
is: C00130
initial amount: NaN
is: HMDB00175
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C67H108N5O51SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110058#_5ea4cbcf_4033_4caf_b02a_eb3f323522e6
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: A0PJJ9
boundary condition: true
name: GGT7
is encoded by: hsa:2686

metaM acgal c
name: N-acetyl-D-galactosamine
is: CHEBI:28037
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00212
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
boundary condition: false
constant: false

metaR r1920
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110058#_84ea2c4a_dc31_49f5_b323_c7c05d9d08ec
has only substance units: false
type: Species
constant: false
name: ACOX1
initial concentration: NaN
is encoded by: hsa:51
is: SBO:0000252
initial amount: NaN
is: B4DK61
boundary condition: true

metaM hcys L c
has only substance units: false
constant: false
type: Species
is: CHEBI:17588
boundary condition: false
name: L-homocysteine
initial amount: NaN
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: SBO:0000247
is: HMDB00742
initial concentration: 1.0

metaR PROSTGF2t
name: prostaglandin uniport
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110058#

metaR r1929
product: MODEL1310110058#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_016d772a_5077_411b_99c7_2efda9fc8f7f
is: SBO:0000252
boundary condition: true
is: Q6P1K9
name: PANK2
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:80025

metaR SUBEACTD
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_73ba7e7d_6e05_4304_9d2c_8a6c12bf2f34
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: PDE6D
boundary condition: true
constant: false
is: O43924
is encoded by: hsa:5147

http://identifiers.org/biomodels.db/MODEL1310110058#_652cbf91_6d43_4358_a3e9_d02cd6eb9ba5
is encoded by: hsa:8372
is: O43820
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: HYAL3

metaR r0552
is: SBO:0000176
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.5.1
fast: false
modifier: MODEL1310110058#
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_0981dae4_1e2b_4e80_8d70_410406ff10dc
is encoded by: hsa:2876
name: GPX1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaM c51crn e
is: SBO:0000247
initial concentration: 1.0
is: HMDB02366
notes: FORMULA: C12H21NO4 CHARGE: 0
constant: false
name: tiglyl carnitine
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaR THMMPtm
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
name: Thiamine monophosphate transport, mitochondrial
reversible: true
is: SBO:0000185
type: Reaction

metaR GALt4
fast: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
name: galactose transport via sodium symport
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_77d04885_737c_4e9a_bee1_de7c4c61c4a0
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:64077
is: SBO:0000252
has only substance units: false
is: Q9H008
type: Species
name: LHPP
boundary condition: true

metaR RE0577C
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
type: Reaction
is described by: ECO:0000000
name: RE0577
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is: SBO:0000176
modifier: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110058#

metaR GRTTx
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.5.1.1
kinetic law: MODEL1310110058#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reversible: false
reactant: MODEL1310110058#
name: geranyltranstransferase
product: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176

metaR EX ivcrn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaM glyald c
constant: false
name: D-Glyceraldehyde
initial concentration: 1.0
is: HMDB01051
boundary condition: false
is: CHEBI:17378
has only substance units: false
is: C00577
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577

http://identifiers.org/biomodels.db/MODEL1310110058#_c727b4a9_efe2_4f89_bec9_0ecac403dfb3
constant: false
boundary condition: true
has only substance units: false
name: PIK3CA
is encoded by: hsa:5290
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: P42336

http://identifiers.org/biomodels.db/MODEL1310110058#_e28d3f31_e9fb_4a31_b4be_b93b939cdadb
is encoded by: hsa:2645
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: GCK
initial concentration: NaN
is: Q53Y25
initial amount: NaN

metaR DOLPGT1 Ler
product: MODEL1310110058#
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
fast: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
reversible: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.267

metaR r1806
is described by: ECO:0000000
reactant: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaM hdd2coa m
has only substance units: false
initial concentration: 1.0
is: CHEBI:61526
is: SBO:0000247
name: trans-Hexadec-2-enoyl-CoA
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: C05272
constant: false
is: HMDB03945
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_dc951b31_715d_4e01_8ab2_08a2e1786b95
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:PRO1933
name: _PRO1933_1_m
constant: false
boundary condition: true
initial concentration: NaN

metaM dlnlcgcoa r
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: C03595
initial concentration: 1.0
type: Species
is: CHEBI:27979
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_82456fab_58fb_4f5a_8a02_ac88b0fe5951
name: B4GALT2
is encoded by: hsa:8704
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O60909
constant: false
initial concentration: NaN
type: Species

metaR P4508B13r
is version of: http://identifiers.org/ec-code/1.14.13.95
name: sterol 12-alpha-hydroxylase (nadh)
modifier: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
is described by: ECO:0000269
reversible: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM ump c
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: UMP
type: Species
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
is: C00105

metaR RE2541E
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
name: RE2541

metaR r1807
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
reversible: false
fast: false
name: Y+LAT2 Utilized transport

metaM dadp m
is: SBO:0000247
boundary condition: false
name: dADP(3-)
is: HMDB01508
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
is: CHEBI:57667
has only substance units: false

metaR MMTSADm
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
reversible: false
fast: false
reactant: MODEL1310110058#
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_c85b6eea_39f6_49a9_9550_9d1e0fad5c05
type: Species
initial amount: NaN
is: Q6IBC0
initial concentration: NaN
boundary condition: true
constant: false
name: HMGCL
has only substance units: false
is encoded by: hsa:3155
is: SBO:0000252

metaM CE2433 m
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110058#_8b07da99_ad5c_48c3_9aaf_21d1e36ce91d
is: SBO:0000252
name: ACAD8
is: Q6ZWP6
type: Species
is encoded by: hsa:27034
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_181ad8ab_c05d_4c0e_ba9b_407aaf70fc29
is: Q11201
initial concentration: NaN
boundary condition: true
name: ST3GAL1
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6482
constant: false
has only substance units: false

metaM prostgh2 r
is: HMDB01381
is: SBO:0000247
name: prostaglandin H2(1-)
type: Species
initial concentration: 1.0
is: CHEBI:57405
constant: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
boundary condition: false

metaM malcoa r
is: HMDB01175
type: Species
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: SBO:0000247
is: CHEBI:57384
name: malonyl-CoA(4-)
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r0669
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is: SBO:0000176
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
reversible: false
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_bfb2a3b5_d4c5_4489_be51_661879ddf8f1
has only substance units: false
is encoded by: hsa:6470
initial concentration: NaN
is: SBO:0000252
is: P34896
constant: false
type: Species
initial amount: NaN
boundary condition: true
name: SHMT1

metaM f1p c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18105
name: D-Fructose 1-phosphate
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
is: C01094
has only substance units: false
is: HMDB01076
initial amount: NaN
type: Species
boundary condition: false

metaR PACCOAL
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110058#
type: Reaction
name: phenylacetate-CoA ligase

metaR ARGtiDF
name: L-arginine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
product: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false

metaR HMGCOAtx
fast: false
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
is: SBO:0000185
reversible: true
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110058#_5a9f3344_bd15_4f8f_9279_c7d693ec2adb
type: Species
name: GSR
initial amount: NaN
is encoded by: hsa:2936
is: P00390
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR r2196
type: Reaction
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_3f8759b9_2b43_4156_a91d_2228a1950df9
type: Species
is: P28331
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:4719
constant: false
name: NDUFS1
initial concentration: NaN
boundary condition: true

metaM vacc e
type: Species
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
constant: false
name: trans-vaccenate
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:30828

metaR r0668
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
modifier: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.2.19
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_7ad1d831_6b4d_47fb_8cec_7828d60af60f
is encoded by: hsa:AA278423
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _AA278423_1_c
has only substance units: false
initial amount: NaN

metaR H2Oter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110058#
name: H2O endoplasmic reticulum transport
fast: false
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
is: SBO:0000185
reversible: true

metaM g1p c
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01586
is: CHEBI:58601
is: SBO:0000247
name: D-Glucose 1-phosphate
is: C00103
constant: false
type: Species

metaR r0339
fast: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
modifier: MODEL1310110058#
is described by: ECO:0000000
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
kinetic law: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176

metaM elaid e
has only substance units: false
is: HMDB00573
name: elaidate
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:30825
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
type: Species
constant: false

metaM chtn e
is: SBO:0000247
constant: false
is: HMDB03362
initial concentration: 1.0
type: Species
name: chitin
initial amount: NaN
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
boundary condition: false
is: CHEBI:17029
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_75429de5_6195_4377_9ddc_1cb798b250bc
constant: false
name: SLC25A2
is: Q9BXI2
boundary condition: true
is encoded by: hsa:83884
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaR DHPM1
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
fast: false
reversible: false
name: dihydropyrimidinase (5,6-dihydrouracil)
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
is version of: http://identifiers.org/ec-code/3.5.2.2
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000176

metaR r2195
product: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_34056dd2_7de7_4739_9f93_e9f4cf168708
is: O95992
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9023
constant: false
has only substance units: false
name: CH25H

http://identifiers.org/biomodels.db/MODEL1310110058#_097f4e7a_743b_4018_82a4_c5125c3cf5c1
name: EHHADH:ACAA1:ACOX1
is encoded by: hsa:1962
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000297
initial concentration: NaN
type: Species
has part: Q9NY65

http://identifiers.org/biomodels.db/MODEL1310110058#_70ddc184_39c5_4b35_ae80_dc4ddc74935f
name: _AW299740_1_m
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AW299740
constant: false
is: SBO:0000252
type: Species

metaR DTMPK
fast: false
product: MODEL1310110058#
is: SBO:0000176
name: dTMP kinase
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_c1fe95d2_4b9a_4680_9139_689972fb2e21
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: PDE6G
is encoded by: hsa:5148
is: P18545

metaR r2194
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_3eab451b_e746_4b4d_8dfa_e23d4f7a36b4
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: UCK2
is: Q9BZX2
constant: false
is encoded by: hsa:7371
boundary condition: true
has only substance units: false

metaM vacc c
is: C08367
constant: false
is: SBO:0000247
name: trans-vaccenate
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
initial amount: NaN
type: Species
is: CHEBI:30828
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_a9739ca9_79ed_4217_b319_786cae24cc73
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: XDH
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7498
is: P47989
has only substance units: false

metaR r2310
product: MODEL1310110058#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110058#
type: Reaction

metaM elaid c
name: elaidate
constant: false
initial concentration: 1.0
is: HMDB00573
is: SBO:0000247
initial amount: NaN
is: CHEBI:30825
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
boundary condition: false
type: Species
has only substance units: false

metaR r2193
reversible: true
modifier: MODEL1310110058#
fast: false
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_be45dc40_fe21_46ac_a850_42a72849262d
constant: false
name: NDUFAB1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: O14561
type: Species
initial concentration: NaN
is encoded by: hsa:4706

http://identifiers.org/biomodels.db/MODEL1310110058#_1c31b3f4_9c9c_4dd1_a200_1d52fd978715
initial concentration: NaN
is encoded by: hsa:AF116616
is: SBO:0000252
initial amount: NaN
name: _AF116616_1_m
boundary condition: true
has only substance units: false
constant: false
type: Species

metaR DNDPt28m
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110058#
name: dCDP transport via dGDP antiport
reversible: false
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000185

metaM cs e deg5 l
type: Species
boundary condition: false
is: CHEBI:57737
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00868
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
has only substance units: false
notes: FORMULA: C31H47NO35S3 CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110058#_33f893e4_ca3c_4994_9df5_96265af13d1a
initial concentration: NaN
is: Q9NVF9
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:55224
name: ETNK2
boundary condition: true
initial amount: NaN
constant: false

metaR ALADGLNexR
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110058#
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange

metaR SRTNt6 2 r
fast: false
reversible: true
type: Reaction
is: SBO:0000185
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110058#_16644447_a14b_48e2_a213_5f85009310b3
is: SBO:0000252
constant: false
name: _AA081045_1_m
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA081045

http://identifiers.org/biomodels.db/MODEL1310110058#_32b1fb40_fd4c_4ddc_834c_89c95315d484
boundary condition: true
has only substance units: false
is: O43272
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PRODH
constant: false
type: Species
is encoded by: hsa:5625

metaR r2311
kinetic law: MODEL1310110058#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_038f7a57_d99f_4802_9fc7_6c30f6f806e1
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P27707
is encoded by: hsa:1633
type: Species
is: SBO:0000252
name: DCK

http://identifiers.org/biomodels.db/MODEL1310110058#_056c5f31_4e8f_4a41_9aff_926edf9bc2ab
is encoded by: hsa:6821
initial concentration: NaN
is: P51687
is: SBO:0000252
boundary condition: true
name: SUOX
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR FAOXC12C12OHm
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR C10DCc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR SUCOASm
type: Reaction
product: MODEL1310110058#
is: SBO:0000176
name: Succinate--CoA ligase (ADP-forming)
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is described by: ECO:0000000
reactant: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_6b36f6f1_eaa4_4637_b1bf_e4b8ee15d138
is encoded by: hsa:221
boundary condition: true
initial concentration: NaN
name: ALDH3B1
is: P43353
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_f84f094c_ad0d_4e69_a33d_c0d0303ada7c
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PECR
is encoded by: hsa:55825
boundary condition: true
type: Species
is: SBO:0000252
is: Q9BY49

http://identifiers.org/biomodels.db/MODEL1310110058#_1f56ed02_b034_41e7_981a_89a2c4334ac4
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AI601100_1_m
is encoded by: hsa:AI601100
type: Species
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_d40345e9_2908_41a2_872f_3d550357a0e5
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:158
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ADSL
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_0966aaaa_f77f_4c2c_8b50_136fa1c18046
constant: false
is encoded by: hsa:8802
initial concentration: NaN
is encoded by: hsa:8801
name: SUCLG2:SUCLG1
has only substance units: false
is: SBO:0000297
boundary condition: true
initial amount: NaN
has part: P53597
type: Species
has part: Q96I99

metaR FAS100COA
product: MODEL1310110058#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
name: fatty acyl-CoA synthase (n-C10:0CoA)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

metaR S6TASE9ly
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110058#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: true
is: SBO:0000176

metaR GTHRDtr
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
name: glutathione transport via diffusion
type: Reaction
fast: false
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000000

metaM dcamp c
name: N6-(1,2-Dicarboxyethyl)-AMP
is: CHEBI:57567
initial concentration: 1.0
is: C03794
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00536
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794

metaR r2312
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
type: Reaction

metaM andrstandn r
initial amount: NaN
is: CHEBI:15994
boundary condition: false
is: HMDB00899
type: Species
name: 5alpha-androstane-3,17-dione
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
constant: false
initial concentration: 1.0
has only substance units: false

metaR NACHEX2ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110058#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110058#
product: MODEL1310110058#

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM utp e
constant: false
type: Species
name: UTP(4-)
is: SBO:0000247
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:46398

metaM gdpmann c
constant: false
name: GDP-alpha-D-mannose(2-)
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57527
is: SBO:0000247
initial concentration: 1.0
is: HMDB01163

metaM fe2 c
name: Fe2+
initial amount: NaN
initial concentration: 1.0
is: HMDB00692
is: CHEBI:29033
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: C00023
boundary condition: false

metaR ACALDt
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true
type: Reaction
name: acetaldehyde reversible transport
fast: false
product: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_0b7219e0_04ac_431c_9f7a_a4ea47ed2c7f
boundary condition: true
is: Q9H2H9
initial concentration: NaN
has only substance units: false
is encoded by: hsa:81539
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: SLC38A1

metaM tym c
initial amount: NaN
is: HMDB00306
is: CHEBI:327995
name: tyraminium
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
constant: false
initial concentration: 1.0
boundary condition: false

metaR r2313
product: MODEL1310110058#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_ee4dab38_b566_4c1f_92c3_9708edecd2f6
name: SLC38A4
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q969I6
boundary condition: true
initial amount: NaN
is encoded by: hsa:55089
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_7335df57_3412_44f2_b91c_d103e216c9a9
is: A8K7J7
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3098
initial amount: NaN
name: HK1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_7df99e74_f573_4cb5_86ba_68b5ef4fe5ae
is encoded by: hsa:27430
has part: Q9NZL9
is: SBO:0000297
type: Species
has only substance units: false
name: MAT2B:MAT2A
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaM xol7a r
boundary condition: false
is: CHEBI:1296
initial amount: NaN
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
name: 20-hydroxycholesterol
is: HMDB01496
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_62826425_4db6_4ac4_b4d1_46e526a19466
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:AU149534
is: SBO:0000252
has only substance units: false
name: _AU149534_1_e

metaM malthp e
type: Species
initial amount: NaN
name: maltoheptaose
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
initial concentration: 1.0
boundary condition: false
is: C01936

metaR ALAASNNaEx
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110058#
is described by: ECO:0000269
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#

metaR r0119
is described by: ECO:0000000
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
type: Reaction
reactant: MODEL1310110058#
reversible: false
fast: false
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110058#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is: SBO:0000176

metaR H2Otp
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
reversible: true
name: H2O transport, peroxisomal
fast: false
is: SBO:0000185

metaR ALCD21 D
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
kinetic law: MODEL1310110058#
name: alcohol dehydrogenase (D-1,2-propanediol)
is version of: http://identifiers.org/ec-code/1.1.99.24
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reactant: MODEL1310110058#
reversible: false
is: SBO:0000176
product: MODEL1310110058#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110058#_55033e8a_8c05_475b_8660_08ddd71549bc
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:8867
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SYNJ1
is: O43426

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR r2314
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#

metaR MALSO3tm
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
name: Malate:sulfite antiport, mitochondrial

metaM nac c
is: HMDB01488
name: Nicotinate
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:0
is: C00253
initial concentration: 1.0
notes: FORMULA: C6H4NO2 CHARGE: -1
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_89e97f3e_d5c5_43ac_810d_99c027476cae
constant: false
name: ACADSB
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P45954
type: Species
is encoded by: hsa:36

http://identifiers.org/biomodels.db/MODEL1310110058#_c7972e01_d904_452f_9944_009a1bf15556
name: UGP2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q16851
boundary condition: true
has only substance units: false
is encoded by: hsa:7360
constant: false
type: Species

metaM utp c
initial amount: NaN
type: Species
constant: false
name: UTP
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C00075
is: HMDB00285
boundary condition: false
is: CHEBI:46398

metaR LAPCOAe
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
type: Reaction
is described by: ECO:0000134
name: LAPCOAe
is: SBO:0000176
reversible: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:

metaM CE5236 n
constant: false
is: HMDB03952
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
initial concentration: 1.0
is: CHEBI:28002

metaR r2315
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true

metaR RE0344C
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0344
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_6276f5f4_ecf6_48f9_9ff1_660fad19a20c
is encoded by: hsa:79611
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9H6R3
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: ACSS3

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR H2Otn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000
name: H2O transport, nuclear
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true

metaR TETPENT6COAtx
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#

metaR HIVCACBP
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaM od2coa c
is: C16218
is: HMDB06529
type: Species
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:50570
name: trans-Octadec-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110058#_004bbb2a_1e2d_4d92_ac9a_b2cdcbc0a2fc
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC5A5
type: Species
boundary condition: true
is encoded by: hsa:6528
is: Q92911
is: SBO:0000252
constant: false

metaR EHGLATm
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: false
fast: false
kinetic law: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110058#

metaR RE0452M
product: MODEL1310110058#
is described by: ECO:0000000
name: RE0452
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
fast: false

metaM ksii core2 pre2 g
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: C00130
has only substance units: false
type: Species
is: HMDB00175
constant: false
name: keratan sulfate II biosynthesis, precursor 2

metaM nac e
is: C00253
initial amount: NaN
is: HMDB01488
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Nicotinate
notes: FORMULA: C6H4NO2 CHARGE: -1
is: CHEBI:0
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_1fd1ce17_5591_481c_914d_b72c7545313b
constant: false
is encoded by: hsa:2645
is: SBO:0000252
name: GCK
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_10e01e12_a9bc_4a8d_8786_bc05c97006d4
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4704
is: Q16795
is: SBO:0000252
constant: false
initial concentration: NaN
name: NDUFA9
type: Species

metaR PGLYCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
name: phosphatidylglycerol transport
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110058#

metaM mi1p D c
boundary condition: false
name: 1D-myo-inositol 1-phosphate(2-)
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB02985
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
has only substance units: false
is: CHEBI:58433
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_3acfadda_bcd2_456b_8c6f_4922c66df4f4
boundary condition: true
is: Q59EH3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:52
initial concentration: NaN
name: ACP1
has only substance units: false
constant: false
type: Species

metaM 6pgl r
boundary condition: false
is: HMDB01127
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: CHEBI:57955
has only substance units: false
type: Species
initial concentration: 1.0
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
is: SBO:0000247
constant: false
initial amount: NaN

metaM glyphe c
notes: FORMULA: C11H14N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/97415
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
name: Glycylphenylalanine
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_268d973b_a85e_4b35_b180_9e3aacbf3ac2
is: Q9NR45
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: NANS
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54187

metaM ins c
constant: false
is: HMDB00195
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:17596
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
name: Inosine
initial amount: NaN
type: Species
is: C00294
initial concentration: 1.0

metaM dadp n
is: CHEBI:57667
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
is: HMDB01508
name: dADP(3-)
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false

metaR r2316
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110058#

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b909298e_a57a_466e_8d59_edff6093ea20
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:5464
has only substance units: false
name: PPA1
initial concentration: NaN
is: SBO:0000252
is: Q15181

metaM n2m2nm l
initial amount: NaN
is: HMDB00573
constant: false
is: CHEBI:30825
boundary condition: false
is: SBO:0000247
notes: FORMULA: C58H97N5O41 CHARGE: 0
type: Species
name: n2m2nmasn (w/o peptide linkage)
initial concentration: 1.0
has only substance units: false

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR TDCHOLAte
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110058#
name: bile acid intracellular transport
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_787171bb_844e_4cb9_b88e_734369eb300b
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PC
is encoded by: hsa:5091
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaR AKR1D
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is: SBO:0000176
reversible: false
modifier: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is version of: http://identifiers.org/ec-code/1.3.1.3
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR r2317
reactant: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM mi145p c
is: CHEBI:203600
type: Species
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: HMDB01498
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
has only substance units: false
initial amount: NaN
boundary condition: false

metaR ADCim
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
name: Acetoacetate decarboxylation (irreversible), mitochondrial
reversible: false
reactant: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_43862f10_6e05_47e2_9994_30c47f57a965
is encoded by: hsa:27124
is: Q15735
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: INPP5J
initial concentration: NaN
boundary condition: true

metaR FTHFL
modifier: MODEL1310110058#
reversible: true
name: Formate-tetrahydrofolate ligase
product: MODEL1310110058#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.5
is described by: ECO:0000134
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR URIK1
is version of: http://identifiers.org/ec-code/2.7.1.48
kinetic law: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110058#
name: uridine kinase (ATP:Uridine)
is: SBO:0000176
product: MODEL1310110058#
fast: false

metaR RE0944E
is: SBO:0000176
type: Reaction
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
name: RE0944

http://identifiers.org/biomodels.db/MODEL1310110058#_3120078c_92fb_4428_bef5_6035b4f94398
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P07954
is: SBO:0000252
constant: false
is encoded by: hsa:2271
type: Species
boundary condition: true
name: FH

metaR r0885
is version of: http://identifiers.org/ec-code/1.3.1.38
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000185

metaR r2318
fast: false
kinetic law: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM fol c
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00121
boundary condition: false
name: Folate
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
constant: false
is: SBO:0000247

metaR r0960
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
fast: false
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000185
reversible: true

metaM pail5p hs c
has only substance units: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
is: CHEBI:57795
is: SBO:0000247

metaR H2Otm
reversible: true
modifier: MODEL1310110058#
is described by: ECO:0000269
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
type: Reaction
name: H2O transport, mitochondrial
fast: false
is: SBO:0000185

metaM fe2 e
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
has only substance units: false
initial concentration: 1.0
is: HMDB00692
type: Species
boundary condition: false
is: CHEBI:29033
name: Fe2+

http://identifiers.org/biomodels.db/MODEL1310110058#_50741e18_2d43_4537_b5a2_3e1127671ccd
name: XDH
initial amount: NaN
boundary condition: true
is: P47989
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:7498

http://identifiers.org/biomodels.db/MODEL1310110058#_c4fa8b11_da9e_43cb_beed_f420829aa23a
name: DPYSL3
constant: false
is: Q8IXW6
has only substance units: false
type: Species
is encoded by: hsa:1809
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_e09287a9_2ba4_4a5c_905c_6aae60c1d227
boundary condition: true
is encoded by: hsa:9551
is: SBO:0000252
has only substance units: false
constant: false
name: ATP5J2
initial amount: NaN
initial concentration: NaN
type: Species
is: Q6IBB3

http://identifiers.org/biomodels.db/MODEL1310110058#_b6402521_bdc5_475f_b7c4_5798f976875f
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: NDUFA13
boundary condition: true
is encoded by: hsa:51079
is: Q9P0J0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_36159daa_9e6f_4b9b_ac1f_3ff0cb13bbee
is encoded by: hsa:5151
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PDE8A
type: Species
is: SBO:0000252
is: H0YMZ7
boundary condition: true
constant: false

metaR EX decdicrn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_c84875a3_097f_4749_808f_ab5a06dc69fc
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5152
name: PDE9A
constant: false
has only substance units: false

metaR HMGCOAtm
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction
product: MODEL1310110058#
fast: false
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true

metaR r2319
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_c2a661a5_ec65_4a69_8088_36d556ca275d
name: NDUFB7
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: P17568
has only substance units: false
is encoded by: hsa:4713

metaR RE1845X
is: SBO:0000176
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
is described by: ECO:0000000
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
type: Reaction
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
name: RE1845
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_7afd6c04_f9fb_4b7f_a1f0_0a72ae11280f
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3948
has only substance units: false
name: LDHC
initial amount: NaN
type: Species
boundary condition: true
is: P07864

http://identifiers.org/biomodels.db/MODEL1310110058#_b57277d8_6b81_4869_8f4b_d93957118575
is: O75414
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: NME6
boundary condition: true
is encoded by: hsa:10201

metaR PSP L
product: MODEL1310110058#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
name: phosphoserine phosphatase (L-serine)
kinetic law: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.3
modifier: MODEL1310110058#
reversible: false
type: Reaction
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_788ed509_facb_4c83_9ef6_dcb03e077657
is: Q99714
initial concentration: NaN
is encoded by: hsa:3028
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: HSD17B10

metaR P5CRm
modifier: MODEL1310110058#
fast: false
type: Reaction
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
reversible: false
name: pyrroline-5-carboxylate reductase (m)
is described by: ECO:0000304

metaR RE1526M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
name: RE1526
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110058#
reversible: true

metaM tetpent6 c
constant: false
type: Species
has only substance units: false
is: HMDB06322
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial concentration: 1.0
name: tetracosapentaenoic acid, n-6
initial amount: NaN

metaR CLFORtex
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000304
is: SBO:0000185
name: chloride transport via formate countertransport
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#

metaM gdp c
is: HMDB01201
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: GDP
is: CHEBI:58189
is: C00035

metaM HC02121 c
is: CHEBI:58758
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
name: S-(hydroxymethyl)glutathione(1-)
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: SBO:0000247

metaR FACOAL224
product: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110058#
name: fatty-acid--CoA ligase
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true

metaM duri n
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
type: Species
constant: false
name: 2'-deoxyuridine
has only substance units: false

metaR r2035
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_2dc947a6_e1ea_447a_8e67_56e7c006363f
has only substance units: false
initial amount: NaN
name: GGH
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8836
is: SBO:0000252
is: Q92820
type: Species

metaM dhor S c
is: CHEBI:30864
initial amount: NaN
name: (S)-dihydroorotate
type: Species
boundary condition: false
is: HMDB03349
has only substance units: false
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR DGCHOLtx
kinetic law: MODEL1310110058#
name: bile acid intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110058#

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_404ef83f_672e_4f19_9ad0_c530262f6e93
is: SBO:0000252
name: SLC10A1
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6554
is: B2RA41

metaM creat c
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:16919
name: creatine
is: HMDB00064
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false

metaM adpcoa x
is: HMDB04047
constant: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: C14143
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
name: adipoylcoa

http://identifiers.org/biomodels.db/MODEL1310110058#_b0b3d98c_f9f3_4aa9_96d4_1d28f7f91039
initial concentration: NaN
name: _AA977580_1_c
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:AA977580
constant: false
is: SBO:0000252

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_e3bb4fbb_ba4b_43cc_bc59_f83dfcfc663d
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: Q9Y2C5
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10050
name: SLC17A4
constant: false

metaR CYTDtm
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
name: cytidine facilated transport in mitochondria
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110058#
is described by: ECO:0000269
reversible: true

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR FACOAL226
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
name: fatty-acid--CoA ligase
is: SBO:0000176
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
kinetic law: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110058#

metaM ins e
type: Species
is: C00294
initial amount: NaN
initial concentration: 1.0
is: HMDB00195
boundary condition: false
constant: false
is: CHEBI:17596
has only substance units: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
name: Inosine

metaR CYTK13n
reversible: true
reactant: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dATP),nuclear
type: Reaction
product: MODEL1310110058#

metaM glyphe e
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
initial amount: NaN
name: Glycylphenylalanine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/97415
has only substance units: false
constant: false

metaR NTD5m
kinetic law: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dTMP), mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110058#
is: SBO:0000176
reversible: false

metaR SPODMm
name: superoxide dismutase
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.15.1.1
is: SBO:0000176
reversible: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
type: Reaction
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
product: MODEL1310110058#

metaM pail5p hs n
is: CHEBI:57795
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM dlnlcgcoa c
type: Species
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
boundary condition: false
initial amount: NaN
constant: false
name: dihomo-gamma-linolenyl coenzyme A
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27979
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_18fbce21_c8d8_446d_9b32_6983869a89fc
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: HMGCS2
is: P54868
is encoded by: hsa:3158
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_db9a91a6_d588_46ec_a980_c3a476cd1df7
is: SBO:0000252
name: HSD17B4
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:3295
is: E9PB82
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_87732f84_dcb0_4414_9b08_27d1a2dedd9c
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ATP5F1
constant: false
type: Species
has only substance units: false
is encoded by: hsa:515
is: Q08ET0
is: SBO:0000252

metaR FAOXC12DCTc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_13f3b9ef_02ef_4463_9fc0_a5d0d54f637b
is encoded by: hsa:6319
has only substance units: false
initial amount: NaN
is: O00767
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SCD

metaR r0226
reversible: false
modifier: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:

metaR MGCHrm
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.18
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
is described by: ECO:0000269
product: MODEL1310110058#
fast: false

metaM creat e
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
is: CHEBI:16919
initial concentration: 1.0
is: HMDB00064
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: creatine

metaR SERLYSNaex
fast: false
notes: GENE_ASSOCIATION: (9056.1 and 6519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
type: Reaction
is described by: ECO:0000212
is: SBO:0000185
kinetic law: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
name: Serine/Lysine Na-dependent exchange (Ser in)
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_c16174f7_b52c_47ae_8dfe_6b89bef141bd
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:6487
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110058#_fe4b9b2c_1a90_4d32_a8f9_d14967a47c30
type: Species
initial amount: NaN
is encoded by: hsa:AI684467
boundary condition: true
initial concentration: NaN
name: _AI684467_1_m
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_d9d3a422_fc84_4ca2_b491_c0b830ce6bbb
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ACAT2
constant: false
has only substance units: false
is: Q9BWD1
is encoded by: hsa:39
type: Species

metaR DOLPMT4 Ler
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110058#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

metaM gdp g
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
is: CHEBI:58189
name: GDP(3-)
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01201
initial amount: NaN

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR H2Otg
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110058#
name: H2O transport, Golgi apparatus
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000185

metaM tetdece1coa c
is: HMDB05066
boundary condition: false
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
name: tetradecenoylcoa
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_b328ba47_bb54_459e_8329_37e616ed0854
name: PLA2G1B
is: P04054
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5319
constant: false
has only substance units: false
type: Species
initial concentration: NaN

metaR DHFR
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
reactant: MODEL1310110058#
name: dihydrofolate reductase
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000254

metaR r0774
modifier: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
reactant: MODEL1310110058#
is described by: ECO:0000000
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
type: Reaction
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176

metaR DOPASULT
is: SBO:0000176
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
reversible: false
is described by: ECO:0000269
name: Dopamine Sulfotransferase
type: Reaction
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
reactant: MODEL1310110058#
product: MODEL1310110058#

metaM atp c
is: C00002
type: Species
is: SBO:0000247
is: CHEBI:30616
has only substance units: false
constant: false
is: HMDB00538
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: ATP(4-)

metaR r0549
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
fast: false
is version of: http://identifiers.org/ec-code/1.6.5.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.1.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.6.99.3

metaR DADAe
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110058#
fast: false
name: Deoxyadenosine deaminase, extracellular
reversible: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT

metaM HC01377 m
is: SBO:0000247
is: CHEBI:27462
initial concentration: 1.0
name: S-(3-Methylbutanoyl)-dihydrolipoamide
type: Species
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

metaM utp n
has only substance units: false
name: UTP(4-)
constant: false
boundary condition: false
type: Species
is: HMDB00285
initial amount: NaN
is: SBO:0000247
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_6321c42f_ee44_41a2_b493_730dbc4cf4ac
boundary condition: true
is: Q8WYR1
constant: false
name: PIK3R5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23533
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_8eb6f652_b017_4f08_8f69_90f110c9563c
type: Species
has only substance units: false
name: _AA526438_1_m
is encoded by: hsa:AA526438
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM tetpent6 e
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
boundary condition: false
name: tetracosapentaenoic acid, n-6
type: Species
constant: false
initial amount: NaN
is: HMDB06322
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_acb9191f_6a2a_4cd2_bb61_9072b7232622
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000297
initial concentration: NaN
constant: false
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110058#_989388a1_7468_488d_9cab_7bf88930d83a
has only substance units: false
name: PRPS2
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: P11908
boundary condition: true
is encoded by: hsa:5634

http://identifiers.org/biomodels.db/MODEL1310110058#_9a4a408f_933e_4188_a60f_558bd739ab5e
constant: false
has part: P08237
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:5213
has only substance units: false
name: PFKM:PFKP
is: SBO:0000297
initial concentration: NaN

metaR SUCCt2m
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110058#
reversible: true
is: SBO:0000185
product: MODEL1310110058#
name: succinate transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110058#_970437cf_7d34_4601_9c35_c8e35734db98
has only substance units: false
type: Species
is: SBO:0000252
is: P36269
is encoded by: hsa:2687
name: GGT5
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaM 4mlacac c
type: Species
is: HMDB02052
boundary condition: false
has only substance units: false
is: CHEBI:17105
name: 4-maleylacetoacetate
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM C05965 e
is: HMDB04243
name: 12(S)-HPETE(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57444

http://identifiers.org/biomodels.db/MODEL1310110058#_2b9a41fb_64ae_41d9_a996_0edb215d9691
is: P34949
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: MPI
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:4351

metaR r1624
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction

metaM 3octdectecoa m
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
boundary condition: false
name: 3,6,9,12-octadecatetraenoylcoa

metaR CTPtn
is described by: ECO:0000000
name: CTP diffusion in nucleus
is: SBO:0000185
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
type: Reaction
kinetic law: MODEL1310110058#
reversible: true
product: MODEL1310110058#

metaR r0732
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaR THMDt4
reactant: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
name: thymidine transport in via sodium symport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
is: SBO:0000185
modifier: MODEL1310110058#
is described by: ECO:0000269
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_6ad816d6_2e6c_4e9a_a74b_2d3edfa9d8a2
type: Species
is: SBO:0000252
initial amount: NaN
name: OXSM
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9NWU1
is encoded by: hsa:54995

metaM g1m8mpdol L r
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: C05870
type: Species
is: SBO:0000247
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_35e4500b_c5ce_4b45_b146_baa756e775fe
boundary condition: true
is encoded by: hsa:4540
has only substance units: false
initial concentration: NaN
type: Species
is: P03915
name: ND5
constant: false
initial amount: NaN
is: SBO:0000252

metaR FPGS6m
fast: false
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
reactant: MODEL1310110058#
name: folylpolyglutamate synthetase (DHF), mitochondrial
is version of: http://identifiers.org/ec-code/6.3.2.17

http://identifiers.org/biomodels.db/MODEL1310110058#_f3f3f55e_d507_45ed_a044_4e2ece062b97
has only substance units: false
is: P31040
initial concentration: NaN
name: SDHA
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6389
constant: false
type: Species
boundary condition: true

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR LPCHOLt
product: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
name: lysophosphatidylcholine transport
fast: false
reactant: MODEL1310110058#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_b73ccaa8_2df2_4253_9723_c7617c98326e
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: VNN3
is: SBO:0000252
is encoded by: hsa:55350

metaM lnlncacoa m
constant: false
is: HMDB06290
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
name: alpha-Linolenoyl-CoA
is: SBO:0000247
is: CHEBI:51985

metaR r1625
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110058#

metaR TETTET6t
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110058#_8004911b_4cf8_41e5_9e20_e5148f89f10e
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
name: PDE9A
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM tethex3 c
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: tetracosahexaenoic acid, n-3
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB02007
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-

metaM HC01496 m
has only substance units: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
name: 2-Amino-3-oxoadipate
initial concentration: 1.0
constant: false
is: CHEBI:28095

http://identifiers.org/biomodels.db/MODEL1310110058#_65b8a2e5_d5aa_43d7_83b2_34b6500d4bbc
has only substance units: false
name: _LOC647190_1_c
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:LOC647190
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_74b18df1_0a5c_4a3d_bb10_7508fcad0678
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:374291
is: O75251
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: NDUFS7
has only substance units: false

metaM m5masnB2 g
is: CHEBI:58282
boundary condition: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: HMDB00968
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR r0670
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
fast: false
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110058#
reversible: false
is: SBO:0000176
type: Reaction

metaR r0731
reversible: false
product: MODEL1310110058#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
is: SBO:0000176

metaR FAEL183
is: SBO:0000176
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
name: fatty-acyl-CoA elongation (n-C18:3CoA)

http://identifiers.org/biomodels.db/MODEL1310110058#_353c9804_6990_48e8_9927_0acb604f13eb
initial concentration: NaN
is encoded by: hsa:HG2846-HT2983
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: _HG2846_HT2983_1_m

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR RPEc
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
is: SBO:0000176
name: ribulose 5-phosphate 3-epimerase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_7529da42_01a3_4cab_bccc_a2aacb9f32c5
is: SBO:0000252
initial amount: NaN
name: PDE9A
is encoded by: hsa:5152
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_37e1128d_29f1_40af_9875_9dc6915a20e9
constant: false
has only substance units: false
name: PDE1B
boundary condition: true
initial concentration: NaN
type: Species
is: Q7Z364
is encoded by: hsa:5153
is: SBO:0000252
initial amount: NaN

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR r0734
type: Reaction
fast: false
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_2b316fa5_c0dd_42ee_8f99_409c90099dcb
is: Q9NQ66
initial concentration: NaN
is encoded by: hsa:23236
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PLCB1

http://identifiers.org/biomodels.db/MODEL1310110058#_874472a6_b752_4559_ac74_53b3111cbc61
is: P08559
constant: false
is: SBO:0000252
type: Species
name: PDHA1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5160
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_151f672d_40cd_44d3_88f0_7111a5bd67a0
name: ACSL6
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: B2RB13
is encoded by: hsa:23305

metaM HC02175 c
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
name: caprate
type: Species
is: CHEBI:27689
initial concentration: 1.0

metaR r1622
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
reversible: true

metaM dopa e
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: SBO:0000247
is: CHEBI:59905
initial concentration: 1.0
initial amount: NaN
constant: false
name: dopaminium(1+)
is: HMDB00073
boundary condition: false
type: Species
has only substance units: false

metaR FAEL184
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
modifier: MODEL1310110058#
name: fatty-acyl-CoA elongation (n-C20:4CoA)
fast: false
reactant: MODEL1310110058#
reversible: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
type: Reaction

metaR SIAT9g
is: SBO:0000176
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.9
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
is described by: ECO:0000000
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#

metaR r1623
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR r1837
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
reversible: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110058#_876097e2_90be_4699_868f_f3e1ebf45b21
boundary condition: true
is encoded by: hsa:60490
initial concentration: NaN
has only substance units: false
is: Q96CD2
is: SBO:0000252
name: PPCDC
constant: false
type: Species
initial amount: NaN

metaM CE2422 m
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB11123
type: Species
is: SBO:0000247
is: CHEBI:28387
constant: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA

metaM tethex3 e
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02007
type: Species
boundary condition: false
name: tetracosahexaenoic acid, n-3
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
initial amount: NaN
has only substance units: false

metaR r0733
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
product: MODEL1310110058#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_011af2d1_46c7_45ce_bdb8_2ca2121ea9c4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: CPT1B
type: Species
is encoded by: hsa:1375
initial amount: NaN
has only substance units: false
is: Q53FV7
constant: false

metaR r0672
reversible: true
reactant: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
modifier: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
kinetic law: MODEL1310110058#
type: Reaction

metaR FAOXC184C164m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_86b876de_da28_44d7_89d2_4ed6891fe592
has only substance units: false
is encoded by: hsa:953
name: ENTPD1
constant: false
type: Species
is: Q86VV3
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR r0456
type: Reaction
kinetic law: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113

http://identifiers.org/biomodels.db/MODEL1310110058#_c1f83525_6e19_47ab_adb7_ad569882f2a0
is: SBO:0000252
boundary condition: true
name: GGT1
is encoded by: hsa:2678
type: Species
is: P19440
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

metaM ksii core2 pre3 g
initial concentration: 1.0
boundary condition: false
is: C00130
has only substance units: false
constant: false
is: HMDB00175
notes: FORMULA: C47H76N4O33X CHARGE: -1
type: Species
name: keratan sulfate II biosynthesis, precursor 3
is: SBO:0000247
initial amount: NaN
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110058#_734c072a_32aa_4855_a1ab_cf70976118e9
has only substance units: false
is: P11310
type: Species
is encoded by: hsa:34
name: ACADM
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR FAOXC200180m
reactant: MODEL1310110058#
fast: false
reversible: false
kinetic law: MODEL1310110058#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_7c681aae_a3d7_48ef_a6e5_cdaa9fe06091
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: P48764
is: SBO:0000252
constant: false
has only substance units: false
name: SLC9A3
is encoded by: hsa:6550

metaM 5dpmev c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: HMDB01090
has only substance units: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
name: (R)-5-Diphosphomevalonate
boundary condition: false

metaR ACOAO7p
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#

metaR PROSTGI2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110058#
product: MODEL1310110058#
name: Prostaglandin I2 transport
reversible: true
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

metaM dhcrm hs c
type: Species
name: dihydroceramide
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:31488
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
has only substance units: false
initial concentration: 1.0

metaM pect e
initial amount: NaN
constant: false
is: HMDB03402
notes: FORMULA: C2535H3509O2535 CHARGE: -1
boundary condition: false
has only substance units: false
name: pectins
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR r1834
reactant: MODEL1310110058#
reversible: false
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#

metaM pap g
is: SBO:0000247
is: HMDB00061
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)
has only substance units: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
boundary condition: false
is: CHEBI:58343

metaM dhap e
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57642
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: HMDB01473
type: Species
has only substance units: false
boundary condition: false
name: glycerone phosphate(2-)
initial amount: NaN

metaR FAOXC164C143m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaR DHCR71r
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reversible: false
type: Reaction
modifier: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#

metaR r1620
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_3fb8a752_b8fb_4048_a25d_046ff0885835
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: PDE9A
is encoded by: hsa:5152

metaM lgnc c
is: CHEBI:31014
initial amount: NaN
is: HMDB02003
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
name: lignocerate
constant: false
type: Species
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547

metaR r0522
modifier: MODEL1310110058#
is: SBO:0000176
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110058#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110058#

metaR AMETtd
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
name: diffusion of S-Adenosyl-L-methionine
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
fast: false

metaR r0735
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110058#
fast: false
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110058#

metaM lald L c
is: HMDB03052
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:18041
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
type: Species
name: (S)-lactaldehyde

http://identifiers.org/biomodels.db/MODEL1310110058#_15e3dd43_501f_4a53_8ec3_d8c71b216a0d
has only substance units: false
is encoded by: hsa:3948
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: LDHC
constant: false
initial amount: NaN

metaM lgnc e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: HMDB02003
is: SBO:0000247
name: lignocerate
constant: false
is: CHEBI:31014
has only substance units: false
type: Species
initial amount: NaN

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaR ECOAH12m
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
kinetic law: MODEL1310110058#
is: SBO:0000176
type: Reaction

metaM g2m8masn r
type: Species
is: SBO:0000247
initial amount: NaN
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
notes: FORMULA: C82H137N2O65X CHARGE: 0
is: C05874
initial concentration: 1.0
constant: false
has only substance units: false

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR r1621
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_710e0da4_74e1_4c13_a6ba_19c9424ca61f
boundary condition: true
is: Q9UJ70
name: NAGK
constant: false
is: SBO:0000252
is encoded by: hsa:55577
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR WHDDCAte
product: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
reactant: MODEL1310110058#
is: SBO:0000185
fast: false
name: xenobiotic transport
kinetic law: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_6cc613d0_2504_4617_81ab_614f57acdf6b
initial concentration: NaN
boundary condition: true
is: B3KQV3
name: PIP4K2C
is encoded by: hsa:79837
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM 2octdectecoa m
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
constant: false
name: 2,6,9,12-octadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110058#_9f7b534c_3b95_4434_bd52_2ef1eb13d20b
type: Species
is encoded by: hsa:6580
has only substance units: false
initial amount: NaN
name: SLC22A1
constant: false
initial concentration: NaN
is: O15245
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_c22fd4d7_4796_43d6_bd9f_27cd1f4efb62
has part: Q9UBK5
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
name: HCST:PIK3CG
constant: false
is encoded by: hsa:5294
is encoded by: hsa:10870
has only substance units: false
type: Species
has part: P48736
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_b75b22bf_9217_4ba0_afa0_3deb75b15cba
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: B2RDU6
name: MVK
boundary condition: true
type: Species
is encoded by: hsa:4598

metaM dhap c
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01473
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate
has only substance units: false
is: C00111
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_a932eccd_156d_4685_9b4c_b106cf4f0fe5
has only substance units: false
initial amount: NaN
boundary condition: true
is: O00750
constant: false
type: Species
is encoded by: hsa:5287
is: SBO:0000252
initial concentration: NaN
name: PIK3C2B

http://identifiers.org/biomodels.db/MODEL1310110058#_61503c77_377f_4215_8059_e7e9061ea411
initial concentration: NaN
is encoded by: hsa:23632
is: A8K3J4
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: CA14

http://identifiers.org/biomodels.db/MODEL1310110058#_080b6392_23e0_4436_a2f5_1f09fdbe8b34
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:6581
name: SLC22A3
boundary condition: true
initial concentration: NaN
is: Q5SYN6
constant: false
initial amount: NaN

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM trdrd m
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:15967

metaR TPI
is version of: http://identifiers.org/ec-code/5.3.1.1
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reversible: true
modifier: MODEL1310110058#
type: Reaction
name: triose-phosphate isomerase
is described by: ECO:0000134

metaR r0523
reversible: false
modifier: MODEL1310110058#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110058#
is described by: ECO:0000000

metaR UAG4E
fast: false
name: UDP-N-acetylglucosamine 4-epimerase
product: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
is described by: ECO:0000304
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.2

metaM 2mp2coa m
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB01011
boundary condition: false
is: CHEBI:27754
has only substance units: false
constant: false
type: Species
name: 2-Methylprop-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110058#_a13b4e65_9518_4b8f_8414_00118b093e9c
is: P21953
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:594
name: BCKDHB
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_a924a524_351e_4b07_84c6_1d5f7521c627
is: Q9Y2D0
type: Species
initial amount: NaN
is encoded by: hsa:11238
constant: false
name: CA5B
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR H2CO3D
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.1
name: carboxylic acid dissociation
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_0631ed21_2cc0_4e27_91cf_9ae381996fb6
is: O15440
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: ABCC5
is encoded by: hsa:10057

metaR PI34P5K
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.68
is: SBO:0000176

metaR RTOTALt
reactant: MODEL1310110058#
name: RTOTAL transport
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
type: Reaction

metaR PI4P3K
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
product: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate 3-kinase
type: Reaction
kinetic law: MODEL1310110058#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.154

metaM leuktrB4 c
type: Species
is: CHEBI:57461
is: SBO:0000247
has only substance units: false
name: leukotriene B4(1-)
constant: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
initial concentration: 1.0
initial amount: NaN

metaR SERGLYexR
reversible: true
type: Reaction
name: L-Serine/Glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
product: MODEL1310110058#
is described by: ECO:0000304
reactant: MODEL1310110058#

metaR CYANt
kinetic law: MODEL1310110058#
name: Cyanide transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is described by: ECO:0000000
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
reversible: true
type: Reaction
fast: false

metaR r2322
reactant: MODEL1310110058#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM pap c
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58343
constant: false
has only substance units: false
is: HMDB00061
type: Species
name: adenosine 3',5'-bismonophosphate(4-)
initial concentration: 1.0

metaM 5htrp c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: 5-hydroxy-L-tryptophan
type: Species
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: CHEBI:17780
boundary condition: false
is: HMDB00472
has only substance units: false

metaM clpndcoa c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: clupanodonyl CoA
type: Species
has only substance units: false
is: HMDB06267
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: C16166
is: http://identifiers.org/pubchem.compound/47205476

metaM subeac x
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H12O4 CHARGE: -2
is: HMDB00893
initial amount: NaN
name: suberic acid
is: SBO:0000247
constant: false
boundary condition: false
type: Species

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR r0679
is described by: ECO:0000000
product: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110058#

metaR r2321
type: Reaction
is: SBO:0000185
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110058#_0ab5c43d_89fe_430c_9904_ca6e205e8375
name: _AA532636_1_m
type: Species
is encoded by: hsa:AA532636
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR ACGALK
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110058#
is: SBO:0000176
name: N-acetylgalactosamine kinase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_feaca253_3ab7_4d97_9b02_163ef39a0eaa
has only substance units: false
name: ME2
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4200
initial amount: NaN
is: P23368
boundary condition: true
type: Species

metaR r0450
type: Reaction
reversible: true
modifier: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is described by: ECO:0000000
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_07234561_1805_4639_9591_fa07565b1d13
is encoded by: hsa:92483
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: Q9BYZ2
name: LDHAL6B
is: SBO:0000252
boundary condition: true

metaR G14T16g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
reversible: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110058#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR r0739
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
product: MODEL1310110058#
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110058#
type: Reaction

metaR r2320
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110058#
reversible: true
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_68b163e8_645a_4fbd_a90e_ccdb6f759b80
is: SBO:0000252
name: ACAA1
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:30
has only substance units: false
is: Q96CA6

metaR SGALSIDEtg
name: sgalside hs intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110058#
reversible: true
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR FAOXC225m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_25f67ee8_681d_4f9e_95f8_d327f0ca6424
is encoded by: hsa:873
initial amount: NaN
is: P16152
name: CBR1
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaR DNDPt16m
fast: false
is described by: ECO:0000269
name: dUDP transport via dADP antiport
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110058#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_040a1cbe_db7e_4459_8663_93edcf97f75e
initial concentration: NaN
type: Species
is: SBO:0000252
name: RRM1
is encoded by: hsa:6240
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: P23921

metaM c4dc c
boundary condition: false
constant: false
is: HMDB02013
initial concentration: 1.0
is: C02862
notes: FORMULA: C11H18NO6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
name: succinyl carnitine
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_98e12759_e876_464d_bd25_9d30a0b9a537
name: AK2
is: SBO:0000252
constant: false
is encoded by: hsa:204
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_2e9c1694_5b55_4530_a0b8_b81ba5420c02
initial concentration: NaN
is: Q16836
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: HADH
is encoded by: hsa:3033
boundary condition: true

metaR C160CPT1
name: production of Palmitoylcarnitine
reversible: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
reactant: MODEL1310110058#
fast: false
is: SBO:0000176
modifier: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000269

metaM L2aadp m
constant: false
is: SBO:0000247
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN
is: HMDB00510
name: L-2-aminoadipate(1-)
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:58672
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5d747662_9287_4743_b0f7_c28f9498d176
is encoded by: hsa:6513
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is: P11166
boundary condition: true
name: SLC2A1
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_880faee3_89a4_4d14_82f3_9027ec38f9d2
constant: false
name: PDHB
initial concentration: NaN
is encoded by: hsa:5162
is: P11177
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR C8DCc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaR MMEm
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/5.1.99.1
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110058#
name: methylmalonyl-CoA epimerase/racemase
is: SBO:0000176
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110058#_4a41c0af_c66a_4e97_9099_c3d593016859
type: Species
initial amount: NaN
is encoded by: hsa:8527
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: DGKD
is: Q16760
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_abb69dca_dffa_4aa4_8d65_439d2c659535
name: _R06874_1_r
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:R06874
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_6df3e3a8_f8f1_4c7a_bde0_7aeeb5860ddf
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P51857
name: AKR1D1
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:6718

metaR SUCCCROT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

metaR URIt5le
product: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
name: uridine transport in via sodium symport (1:2)
reversible: false
reactant: MODEL1310110058#
is described by: ECO:0000134
kinetic law: MODEL1310110058#
fast: false

metaM HC02175 e
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
has only substance units: false
name: caprate
is: SBO:0000247
is: CHEBI:27689
initial amount: NaN

metaM gluside hs r
name: D-glucosyl-N-acylsphingosine
constant: false
is: CHEBI:18368
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

http://identifiers.org/biomodels.db/MODEL1310110058#_49d8848d_b3d1_4860_be0a_b4d9bb6e702a
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:79646
has only substance units: false
type: Species
initial concentration: NaN
is: Q9H999
name: PANK3
constant: false

metaM leuktrC4 r
initial concentration: 1.0
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial amount: NaN
is: CHEBI:57973
has only substance units: false
boundary condition: false
is: HMDB01198
name: leukotriene C4(2-)
constant: false
type: Species
is: SBO:0000247

metaR C3STDH1Pr
name: C-3 sterol dehydrogenase (4-methylzymosterol)
type: Reaction
reversible: false
fast: false
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_2dc61229_bdc4_47bd_a2da_ba31dcf1da80
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q13613
is: SBO:0000252
name: MTMR1
type: Species
initial concentration: NaN
is encoded by: hsa:8776

metaR PRPPS
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110058#
reversible: true
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110058#
name: phosphoribosylpyrophosphate synthetase
is version of: http://identifiers.org/ec-code/2.7.6.1
type: Reaction
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_9424b8ac_66ef_4336_b515_c2ed64f8d2d8
has only substance units: false
is encoded by: hsa:54344
initial concentration: NaN
type: Species
constant: false
name: DPM3:DPM1:DPM2
initial amount: NaN
boundary condition: true
is: SBO:0000297
has part: Q9P2X0
is encoded by: hsa:8818

metaM ttdca c
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: CHEBI:30807
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00806
constant: false
initial concentration: 1.0
name: myristate
is: SBO:0000247
has only substance units: false

metaR HPACtr
fast: false
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: hydroxyphenylacetate transport via diffusion
is described by: ECO:0000000
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB

metaR C100CPT1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_2ce85c0e_5f08_42ec_ad7a_b75005eabe37
is encoded by: hsa:81490
is: Q9BVG9
name: PTDSS2
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR LEUKTRA4tr
reversible: true
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
name: leukotriene intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_f3ec9b30_bce4_44dd_85f0_fc1fab3957a0
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC5A9
is: E9PAK4
type: Species
is encoded by: hsa:200010
boundary condition: true

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM leuktrB4 e
name: leukotriene B4(1-)
type: Species
initial concentration: 1.0
is: HMDB01085
constant: false
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN

metaR FAOXC102C103m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaM tmndnccoa c
is: HMDB06514
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: SBO:0000247

metaM cspg a e
has only substance units: false
is: HMDB00630
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: CHEBI:16040
boundary condition: false
initial concentration: 1.0

metaR FAOXC101m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_ddd5277a_cb60_4bdc_b64a_ec716888f46f
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3157
name: HMGCS1
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_2cc028ee_7a4a_4535_ab0a_e22840a6a4c2
name: PDE9A
is: SBO:0000252
is encoded by: hsa:5152
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaM 2mbcoa m
is: HMDB01041
constant: false
name: 2-methylbutanoyl-CoA(4-)
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033

http://identifiers.org/biomodels.db/MODEL1310110058#_9408b7fd_4df1_4be9_91d3_4b538dabf94a
is encoded by: hsa:1716
name: DGUOK
is: E5KSL6
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM ttdca e
is: C06424
has only substance units: false
is: CHEBI:30807
initial amount: NaN
type: Species
is: HMDB00806
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
constant: false
boundary condition: false
name: tetradecanoate (n-C14:0)
is: SBO:0000247
initial concentration: 1.0

metaR BILDGLCURt
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110058#

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR SGALSIDEtl
name: sgalside hs intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM mercppyr c
initial amount: NaN
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
constant: false
is: CHEBI:57678
is: HMDB01368
name: 3-mercaptopyruvate
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r2329
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110058#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_3f72e4c4_b481_4bc6_9e4a_de39c953d34a
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8396
type: Species
is: P78356
name: PIP4K2B
boundary condition: true
constant: false

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM ump g
has only substance units: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
boundary condition: false
name: UMP(2-)
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57865

metaR PROSTGE2t2
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
kinetic law: MODEL1310110058#
is described by: ECO:0000269
fast: false
reversible: true
name: prostaglandin uniport
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
modifier: MODEL1310110058#

metaR GBGT1
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
product: MODEL1310110058#
type: Reaction
name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
notes: GENE_ASSOCIATION: (26301.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.88 Confidence Level: 4 AUTHORS: PMID:10506200 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.88
modifier: MODEL1310110058#

metaR FAS140COA
is: SBO:0000176
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false
is described by: ECO:0000269
product: MODEL1310110058#
name: fatty-acyl-CoA synthase (n-C14:0CoA)
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

metaR CYTK9n
name: cytidylate kinase (CMP,dCTP),nuclear
reactant: MODEL1310110058#
fast: false
type: Reaction
product: MODEL1310110058#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110058#

metaM hdca c
initial amount: NaN
constant: false
name: palmitate
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
type: Species
boundary condition: false
is: CHEBI:7896
has only substance units: false
initial concentration: 1.0
is: HMDB00220

metaR S4TASE2ly
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110058#
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_b688a8de_bf60_40d7_8ac4_423f2f479445
is encoded by: hsa:8898
initial amount: NaN
type: Species
is: SBO:0000252
is: A6NN98
initial concentration: NaN
name: MTMR2
has only substance units: false
constant: false
boundary condition: true

metaR EX ddecrn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaR 3HBCOAHLm
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: false

metaM thmmp c
name: Thiamin monophosphate
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
initial concentration: 1.0
is: C01081
is: HMDB02666
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:37575
initial amount: NaN
has only substance units: false

metaR RE3272N
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
fast: false
name: RE3272
reversible: true
is: SBO:0000176

metaM accoa x
is: SBO:0000247
is: CHEBI:57288
type: Species
is: C00024
is: HMDB01206
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_975a0096_24cf_400c_8322_d1ad995e2b3b
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:4882
name: NPR2
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_c410f4a0_99bb_472b_ae70_c4d9191fbc19
type: Species
is: Q7GXZ1
name: ND6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4541
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaM glcur c
is: HMDB00127
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:15748
constant: false
has only substance units: false
boundary condition: false
name: D-glucuronate
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

http://identifiers.org/biomodels.db/MODEL1310110058#_48d62883_9f0b_4bf4_8630_a58b2e2fd56e
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: E9KL42
is encoded by: hsa:641371
constant: false
name: ACOT1
boundary condition: true
initial concentration: NaN
type: Species

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM c12dccoa x
name: dodecanedioylcoa
is: HMDB03712
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
boundary condition: false

metaR NaKt
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
name: Na+/K+ exchanging ATPase
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000269
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.6.3.9
reversible: false
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_6cf17b5b_d6f0_4ed3_8f28_034b01cda2ad
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
has part: Q06055
boundary condition: true
is encoded by: hsa:517
is: SBO:0000297
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r2327
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110058#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#

metaR RE1519M
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110058#
modifier: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
name: RE1519
is described by: ECO:0000000
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_a5845a9a_d697_49a4_8a0b_ce08e77ef16b
has only substance units: false
constant: false
initial concentration: NaN
is: Q548A7
initial amount: NaN
is encoded by: hsa:65010
is: SBO:0000252
type: Species
name: SLC26A6
boundary condition: true

metaM hdca e
name: Hexadecanoate (n-C16:0)
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1
boundary condition: false
has only substance units: false
is: HMDB00220
initial concentration: 1.0
is: C00249
is: CHEBI:0
initial amount: NaN
constant: false
is: SBO:0000247

metaM retinol c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:50211
is: HMDB00305
type: Species
name: retinol
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3

metaR PETHCT
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.7.14
is: SBO:0000176
modifier: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
name: phosphoethanolamine cytidyltransferase
is described by: ECO:0000269

metaR AICART
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110058#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.3
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_d3f3a483_b7ce_43d1_9722_82395af0e6bf
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:BC005314
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _BC005314_1_x
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_5250d4f2_7b32_4017_8921_c43c8ca9508f
name: _AI971036_1_m
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:AI971036
constant: false
boundary condition: true

metaR r0994
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true

metaR GBSIDEte
reversible: true
name: globoside transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_63543185_9eec_4341_a731_b11d1fdcf3fa
initial concentration: NaN
name: DECR1
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1666
boundary condition: true
is: Q16698
constant: false
initial amount: NaN

metaR r0899
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
reactant: MODEL1310110058#
name: Amino acid transporter ATB0+ Facilitated diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_e5c6f0c1_2657_4c89_8c86_a9f0a93c436f
name: OXSM
initial concentration: NaN
is encoded by: hsa:54995
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q9NWU1
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_5054c5df_3edf_452a_88db_6cd74abdeadd
name: _AA629629_1_m
constant: false
is encoded by: hsa:AA629629
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r2328
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110058#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110058#_5fd49c03_ca32_42c9_8986_fdc3a51c7a46
is encoded by: hsa:5295
type: Species
has part: P27986
has only substance units: false
constant: false
is: SBO:0000297
name: PIK3CA:PIK3R1
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR ASNtm
is: SBO:0000185
type: Reaction
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is described by: ECO:0000000
product: MODEL1310110058#
name: L-asparagine transport, mitochondrial

metaM citr L m
is: HMDB00904
is: CHEBI:16349
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: L-citrulline
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_5fd3f0bf_bae2_496b_b34f_68c34f75fb2b
is: Q15147
constant: false
initial amount: NaN
name: PLCB4
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5332
initial concentration: NaN

metaM succoa c
initial concentration: 1.0
boundary condition: false
constant: false
name: Succinyl-CoA
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: SBO:0000247
type: Species
is: HMDB01022

metaM cs a deg5 l
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:15936
notes: FORMULA: C23H36O24S CHARGE: -2
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5

metaM cspg a l
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:36005
initial concentration: 1.0
is: HMDB02183
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_c5f84c53_0634_45a9_83fb_931c273dff54
initial amount: NaN
type: Species
is encoded by: hsa:8854
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ALDH1A2
constant: false
is: O94788
boundary condition: true

metaR r0236
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1

metaM met L e
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: HMDB00696
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16643
has only substance units: false
constant: false
is: SBO:0000247
name: L-methionine

metaM tsul e
initial amount: NaN
boundary condition: false
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00257
type: Species
is: CHEBI:16094
is: SBO:0000247

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR r0892
name: Facilitated diffusion
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.2.27
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
modifier: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#

metaM cholate e
name: Cholate
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:29747
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00619

metaR r2325
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#

metaR 4ABUTtcn
type: Reaction
is: SBO:0000185
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
reversible: false
reactant: MODEL1310110058#
is described by: ECO:0000134
name: transport of GABA

metaR GBSIDEtl
kinetic law: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
name: globoside intracellular transport
reactant: MODEL1310110058#
product: MODEL1310110058#

metaM q10h2 e
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
is: HMDB13111
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_e14d1aaa_65e3_42c7_832b_e1eb70f83589
constant: false
is: SBO:0000252
name: GGT1
has only substance units: false
is encoded by: hsa:2678
is: P19440
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_4951cd4e_51be_40bf_9457_ea5dd1b9ab83
is encoded by: hsa:7991
boundary condition: true
type: Species
has only substance units: false
name: TUSC3
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q13454
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_ffc6fc59_c48e_4ded_acd0_b3ffa0451425
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: PLCB1
boundary condition: true
is encoded by: hsa:23236
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_a185d856_a79a_495f_adb4_8e1ad5f6cc72
type: Species
is encoded by: hsa:286016
initial concentration: NaN
constant: false
initial amount: NaN
name: TPI1P2
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM crm hs r
is: CHEBI:52639
type: Species
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR GGH 10FTHF6GLUe
is: SBO:0000176
modifier: MODEL1310110058#
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is described by: ECO:0000000

metaR r2326
fast: false
reversible: true
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_52d4b1bb_a28e_4850_aaf1_fb4b7d41b88c
has part: Q6FIH7
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
boundary condition: true
has only substance units: false
is: SBO:0000297
constant: false
is encoded by: hsa:516
initial concentration: NaN
type: Species
initial amount: NaN

metaR FAOXC141C121x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaM ddsmsterol r
name: 7-dehydrodesmosterol
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03896
constant: false
has only substance units: false
is: CHEBI:27910

metaR EX tdcrn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaM met L c
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: SBO:0000247
initial concentration: 1.0
is: HMDB00696
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:16643
name: L-methionine
constant: false

metaR NRVNCCOAtx
is described by: ECO:0000000
name: fatty acid intracellular transport
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110058#
is: SBO:0000185

metaM tsul c
name: thiosulfate(2-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: HMDB00257
is: CHEBI:16094

metaM cholate c
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00619
is: SBO:0000247
has only substance units: false
is: CHEBI:29747
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
constant: false
initial concentration: 1.0
name: Cholate

metaR r2323
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
product: MODEL1310110058#

metaR TMDPP
name: thymidine phosphorylase
kinetic law: MODEL1310110058#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.4
modifier: MODEL1310110058#
type: Reaction

metaR LYStm
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
name: Lysine mitochondrial transport via ornithine carrier

http://identifiers.org/biomodels.db/MODEL1310110058#_6d9b3fdf_236c_4ef4_96aa_f64819ea1a03
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: P49888
is encoded by: hsa:6783
constant: false
name: SULT1E1
is: SBO:0000252

metaR RE2649C
is: SBO:0000176
reactant: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE2649
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_de2478dd_02e7_44ea_8876_34172b13bf21
name: PTGDS
has only substance units: false
initial amount: NaN
is: P41222
type: Species
boundary condition: true
is encoded by: hsa:5730
is: SBO:0000252
initial concentration: NaN
constant: false

metaM q10h2 c
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
boundary condition: false
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111

metaM c4dc x
type: Species
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
has only substance units: false
is: HMDB02013
initial concentration: 1.0
name: succinyl carnitine
is: C02862
is: SBO:0000247
notes: FORMULA: C11H18NO6 CHARGE: -1

metaR r0990
kinetic law: MODEL1310110058#
reversible: true
fast: false
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_44456e9e_8f46_488b_badb_633d609c82a6
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:8140
type: Species
has only substance units: false
boundary condition: true
has part: Q8IV97
is: SBO:0000297
name: SLC3A2:SLC7A5

http://identifiers.org/biomodels.db/MODEL1310110058#_c00a4aa5_d993_478f_ba60_8f63c073d1bb
is: SBO:0000252
is encoded by: hsa:159963
name: SLC5A12
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: Q1EHB4
initial amount: NaN

metaM glcur e
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
has only substance units: false
type: Species
name: D-glucuronate
boundary condition: false
is: CHEBI:15748
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false

metaR r2324
type: Reaction
reversible: true
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110058#

metaM dmnoncoa c
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
is: HMDB11604
constant: false
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

metaR ACETONEt2m
modifier: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
name: acetone mitochondrial transport via proton symport
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_b08fbfed_1ad7_4f05_9c71_f3f88e89cebf
constant: false
has only substance units: false
type: Species
initial amount: NaN
has part: P08195
is encoded by: hsa:56301
is encoded by: hsa:6520
initial concentration: NaN
has part: Q9NS82
boundary condition: true
name: SLC7A10:SLC3A2
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110058#_5ed314d3_7527_4942_9332_ab117a412d8e
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: ACP2
is: E9PCI1
is encoded by: hsa:53
is: SBO:0000252
constant: false
has only substance units: false

metaR BPNT
modifier: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
name: 3',5'-bisphosphate nucleotidase
is described by: ECO:0000269
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.7
fast: false

metaM doco13ecoa x
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 13-docosenoylcoa
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892791
type: Species

metaR NP1
is described by: ECO:0000304
modifier: MODEL1310110058#
reversible: false
product: MODEL1310110058#
fast: false
name: nucleotide phosphatase
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110058#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_e4621387_4dbf_4c7d_957e_0d1796133c27
name: PRDX2
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:7001
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ab8876ac_62a0_4549_b47e_6483edf99949
boundary condition: true
is encoded by: hsa:6508
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: P48751
is: SBO:0000252
type: Species
name: SLC4A3

metaM tmndnccoa m
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
name: timnodonyl coenzyme A
has only substance units: false
constant: false
is: HMDB06514
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR GTHDH
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
kinetic law: MODEL1310110058#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Glutathione dehydrogenase (dehydroascorbate reductase)
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110058#_7154d21e_f067_4af7_91c7_8bc138d541e1
boundary condition: true
is encoded by: hsa:3295
name: HSD17B4
initial amount: NaN
initial concentration: NaN
constant: false
is: E9PB82
has only substance units: false
type: Species
is: SBO:0000252

metaR r2065
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
reversible: false
type: Reaction
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ump n
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB00288
is: CHEBI:57865
name: UMP(2-)
initial concentration: 1.0

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR 7DHCHSTEROLtr
reactant: MODEL1310110058#
name: cholesterol precursor intracellular transport
reversible: true
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110058#

metaM grdp x
name: geranyl diphosphate(3-)
is: CHEBI:58057
is: HMDB01285
has only substance units: false
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_40188874_5142_4eba_a0ba_2e1e1dd25f01
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:10317
name: B3GALT5
constant: false
initial concentration: NaN
is: Q9Y2C3
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_7641bad8_7ea0_47d8_b3dc_a1591c78f47b
is: Q5JZF5
constant: false
is encoded by: hsa:212
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALAS2

metaM hdca l
initial amount: NaN
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: palmitate
is: CHEBI:7896
type: Species

metaM HC02180 c
has only substance units: false
initial concentration: 1.0
type: Species
name: thromboxane-b2
is: CHEBI:28728
constant: false
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
is: SBO:0000247

metaM r1p c
has only substance units: false
is: SBO:0000247
is: HMDB01489
name: alpha-D-Ribose 1-phosphate
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: CHEBI:57720
is: C00442

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_78f62a5b_a6a1_4e7a_b0c7_5a293e576461
has only substance units: false
type: Species
name: ATP5H
initial amount: NaN
boundary condition: true
is: A0PJH2
is: SBO:0000252
is encoded by: hsa:10476
constant: false
initial concentration: NaN

metaR EX tetdec2crn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaM triodthy c
is: CHEBI:18258
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
is: HMDB00265
initial amount: NaN
type: Species
name: 3,3',5-triiodo-L-thyronine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_02ac3c83_c3fc_4c3e_b0c1_d18f5d83cc5d
type: Species
has only substance units: false
initial amount: NaN
is: Q9BT22
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:56052
initial concentration: NaN
name: ALG1

http://identifiers.org/biomodels.db/MODEL1310110058#_8de160ff_5511_4a3f_997b_8b3914cd3234
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:11332
has only substance units: false
is: O00154
name: ACOT7
initial concentration: NaN

metaM acgam1p c
initial amount: NaN
name: N-Acetyl-D-glucosamine 1-phosphate
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
is: SBO:0000247
is: CHEBI:7125
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: HMDB01367

http://identifiers.org/biomodels.db/MODEL1310110058#_d51a0d4e_5193_4307_bfb2_3dca40ed9324
boundary condition: true
constant: false
is encoded by: hsa:374291
type: Species
initial concentration: NaN
name: NDUFS7
is: O75251
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r1619
is described by: ECO:0000000
modifier: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110058#_05db1fd4_bdb7_43ef_8f17_3a683d690415
has only substance units: false
type: Species
is encoded by: hsa:5142
initial amount: NaN
is: Q5TEK5
is: SBO:0000252
name: PDE4B
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_8562514c_9bbf_4474_a120_a9181f03b203
type: Species
is: P00338
is encoded by: hsa:3939
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: LDHA

metaM citr L e
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species
name: citr_L[e]
boundary condition: false
is: HMDB00904
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR PLA2 2e
is: SBO:0000176
fast: false
modifier: MODEL1310110058#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
name: phospholipase A2
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.1.4

metaM chito2pdol L c
is: CHEBI:12427
initial amount: NaN
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01196
constant: false
boundary condition: false
is: SBO:0000247

metaR RE3565C
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110058#
name: RE3565
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110058#

metaR r0239
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.5.1.9 Confidence Level: 0 AUTHORS: PMID:4140137,PMID:4190298 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
name: N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
reversible: true
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_592697a6_b09a_48a1_b845_a65688db4f3a
type: Species
initial concentration: NaN
name: FOLR1
boundary condition: true
constant: false
is encoded by: hsa:2348
is: P15328
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r1618
product: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110058#
type: Reaction
reversible: true

metaM retinol e
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00305
is: SBO:0000247
has only substance units: false
name: retinol
constant: false
is: CHEBI:50211

metaR TYMSFt
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
name: Tyramine O-sulfate transport (diffusion)
kinetic law: MODEL1310110058#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110058#
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_ba28c297_66ff_44ef_8caa_7623f647f0fe
initial amount: NaN
is: SBO:0000297
constant: false
has only substance units: false
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6NZ59
initial concentration: NaN
is encoded by: hsa:522
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_1982d534_ac45_4a54_8c6c_5be2e0fd71e8
is encoded by: hsa:AI640625
is: SBO:0000252
name: _AI640625_1_c
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

metaM L2aadp c
is: CHEBI:58672
initial amount: NaN
is: SBO:0000247
is: HMDB00510
name: L-2-aminoadipate(1-)
boundary condition: false
has only substance units: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial concentration: 1.0
type: Species
constant: false

metaR DM anth
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR SCP21x
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
name: Sterol carrier protein 2
is version of: http://identifiers.org/ec-code/2.3.1.176
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is described by: ECO:0000269
reversible: true

metaM triodthy e
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
boundary condition: false
is: HMDB00265
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
has only substance units: false

metaM ahcys m
is: C00021
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
constant: false
has only substance units: false
boundary condition: false
is: HMDB00939
initial concentration: 1.0
type: Species
initial amount: NaN

metaR FADH2tru
reactant: MODEL1310110058#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
name: FADH2 transporter, endoplasmic reticulum
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: false

metaM tsul m
initial concentration: 1.0
is: CHEBI:16094
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: HMDB00257
boundary condition: false
name: thiosulfate(2-)
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320

metaR r0517
type: Reaction
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
product: MODEL1310110058#
is: SBO:0000176

metaM g3m8mpdol L r
initial concentration: 1.0
is: SBO:0000247
is: HMDB01342
is: C00459
has only substance units: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
constant: false
is: CHEBI:37568

metaR r1617
modifier: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR G14T7g
fast: false
type: Reaction
modifier: MODEL1310110058#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110058#
reversible: false
is: SBO:0000176

metaR DAGK hs
fast: false
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Diacylglycerol phosphate kinase (homo sapiens)
is: SBO:0000176
kinetic law: MODEL1310110058#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.107
modifier: MODEL1310110058#
is described by: ECO:0000269

metaR SERt4
is described by: ECO:0000269
name: L-serine via sodium symport
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
fast: false

metaM dopa c
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
name: dopaminium(1+)
is: CHEBI:59905
type: Species
boundary condition: false
constant: false
is: HMDB00073
initial concentration: 1.0
initial amount: NaN

metaR SERASNNaEx
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110058#
is described by: ECO:0000269
reversible: false

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM ump r
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00288
constant: false
type: Species
name: UMP
is: CHEBI:57865
has only substance units: false

metaM cysam c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02991
type: Species
name: cysteaminium
is: SBO:0000247
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
boundary condition: false
is: CHEBI:58029

metaM citr L c
initial amount: NaN
boundary condition: false
is: CHEBI:16349
initial concentration: 1.0
type: Species
is: HMDB00904
has only substance units: false
is: SBO:0000247
constant: false
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

metaM 3ddcrn c
initial amount: NaN
notes: FORMULA: C19H37NO5 CHARGE: 0
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00623
type: Species
name: 3-hydroxydodecanoylcarnitine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_4526000f_3361_4900_9dec_55a567b19ded
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: PYCRL
initial amount: NaN
is: Q53H96
boundary condition: true
is encoded by: hsa:65263

metaR FTCD
reversible: false
reactant: MODEL1310110058#
type: Reaction
fast: false
is: SBO:0000176
name: formimidoyltransferase cyclodeaminase
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
product: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#

metaR MI13PP
reactant: MODEL1310110058#
name: inositol-1,3-bisphosphate 3-phosphatase
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is: SBO:0000176

metaR r1616
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true

metaM so4 l
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
is: CHEBI:16189
constant: false
has only substance units: false
type: Species
name: sulfate
boundary condition: false
initial concentration: 1.0

metaM lnlncacoa c
is: HMDB06290
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:51985
boundary condition: false
initial amount: NaN
name: alpha-Linolenoyl-CoA

metaR ARGt4
reversible: false
is: SBO:0000185
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
name: L-arginine transport in via sodium symport
is described by: ECO:0000304
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
fast: false

metaR TCHOLAte
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
name: bile acid intracellular transport
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_b9b0f74e_6eb7_4ea6_9ef0_6abbb2371cbd
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: Q96CA6
initial concentration: NaN
name: ACAA1
initial amount: NaN
is encoded by: hsa:30

metaR r0741
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is: SBO:0000176
fast: false
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
modifier: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reversible: true

metaR r1615
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_3c5e3e6c_23eb_4cf5_b9db_42bc7aa18201
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:C7orf24
initial amount: NaN
name: _C7orf24_1_m
constant: false
is: SBO:0000252

metaM succoa m
is: HMDB01022
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57292
has only substance units: false
initial concentration: 1.0
name: Succinyl-CoA
initial amount: NaN
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091

http://identifiers.org/biomodels.db/MODEL1310110058#_954ebc9b_8600_4216_960d_aea274ebeac1
is: Q86YU0
has only substance units: false
name: CA7
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:766

metaM ksi pre31 g
is: CHEBI:58053
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 31
is: SBO:0000247
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: C00130
boundary condition: false
has only substance units: false
is: HMDB00175
type: Species
constant: false

metaM so4 m
is: HMDB01448
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_8a62e009_9fed_4044_837a_4cff8e00352f
is: SBO:0000297
is encoded by: hsa:498
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
has part: B4DY56
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM 3ddcrn e
type: Species
is: SBO:0000247
is: HMDB00791
name: 3-hydroxydodecanoylcarnitine
initial concentration: 1.0
constant: false
is: C02838
notes: FORMULA: C19H37NO5 CHARGE: 0
initial amount: NaN
boundary condition: false
has only substance units: false

metaM crm hs g
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
initial concentration: 1.0
name: N-acylsphingosine
initial amount: NaN
is: CHEBI:52639
constant: false

metaR CYTK14n
reactant: MODEL1310110058#
name: cytidylate kinase (dCMP,CTP),nuclear
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110058#_d6d68b2f_fea0_4392_84c5_a49cecee38e2
is: P22392
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: NME2
is encoded by: hsa:4831

http://identifiers.org/biomodels.db/MODEL1310110058#_0f0d3849_1f45_4c0a_a0df_51c818947de1
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ATP5A1
is encoded by: hsa:498
type: Species
constant: false
initial concentration: NaN
is: B4DY56

metaM glygn4 e
is: HMDB00122
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Species
is: SBO:0000247
notes: FORMULA: C18H31O16X CHARGE: 0
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:4167
has only substance units: false

metaR RE3000M
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: RE3000
type: Reaction
modifier: MODEL1310110058#
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true

metaR r1614
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
fast: false

metaM HC02180 e
name: thromboxane-b2
type: Species
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:28728
boundary condition: false
has only substance units: false

metaR ABTD
type: Reaction
product: MODEL1310110058#
name: L-arabinitol 4-dehydrogenase
reactant: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is described by: ECO:0000000
reversible: true

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaR ADRNCPT1
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110058#
name: carnitine O-palmitoyltransferase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000

metaM prpncoa m
has only substance units: false
is: HMDB02307
is: CHEBI:57367
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: SBO:0000247
name: acryloyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
boundary condition: false

metaR PAN4PPe
product: MODEL1310110058#
name: PAN4PPe
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000176
reactant: MODEL1310110058#
type: Reaction

metaM glcur r
has only substance units: false
boundary condition: false
constant: false
name: D-glucuronate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
type: Species
is: HMDB00127
is: SBO:0000247

metaM c6dc x
type: Species
is: C14143
boundary condition: false
has only substance units: false
is: HMDB04047
name: adipoyl carnitine
is: SBO:0000247
notes: FORMULA: C13H22NO6 CHARGE: -1
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r1824
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110058#

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_3c78e579_4c31_4704_b5a6_7545a8999eff
type: Species
is: Q9Y6M7
name: SLC4A7
is encoded by: hsa:9497
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR EX ptth LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ptth
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_ea6beec6_1870_4d5a_bbed_163528323d3b
is: SBO:0000297
initial amount: NaN
has only substance units: false
is encoded by: hsa:275
type: Species
has part: P23434
has part: P23378
has part: P48728
constant: false
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:2731
is encoded by: hsa:2653
boundary condition: true
initial concentration: NaN

metaR r1610
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
product: MODEL1310110058#

metaR RE1796R
kinetic law: MODEL1310110058#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796
fast: false
product: MODEL1310110058#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.145

metaR TKT1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.2.1.1
modifier: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
name: transketolase
product: MODEL1310110058#

metaM ppi c
name: Diphosphate
is: CHEBI:0
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3
boundary condition: false
type: Species
is: HMDB00250
is: SBO:0000247
is: C00013
constant: false
has only substance units: false

metaM eicostetcoa c
is: C16164
name: eicosatetranoyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false

metaM nadph r
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00005
type: Species
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247

metaR XOL27OHtm
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reversible: true
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
name: 27 hydroxy cholesterol transport

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaM ctp c
boundary condition: false
constant: false
is: CHEBI:37563
name: CTP
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
is: HMDB00082
is: C00063
is: SBO:0000247

metaR r1611
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
type: Reaction

metaM 2mb2coa m
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57337
has only substance units: false
constant: false
boundary condition: false
name: 2-methylcrotonoyl-CoA(4-)
is: HMDB02054

http://identifiers.org/biomodels.db/MODEL1310110058#_03b4ade1_6a50_47a5_aba2_2aaec0f5d26e
name: B3GALT5
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:10317
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaR TKT2
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.1
is: SBO:0000176
name: transketolase
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true

metaR ADRNCPT2
modifier: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110058#
name: carnitine transferase
is described by: ECO:0000000
fast: false
reversible: false

metaR C4CRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR r0531
type: Reaction
fast: false
modifier: MODEL1310110058#
product: MODEL1310110058#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reversible: true

metaR r0744
fast: false
is: SBO:0000176
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
type: Reaction
reversible: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is described by: ECO:0000000

metaR r1612
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction

metaR RE0935E
reactant: MODEL1310110058#
name: RE0935
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110058#_3c0d2c94_6ca3_445b_aa8d_111541cbdbcd
type: Species
initial concentration: NaN
name: MCCC1
is: Q96RQ3
is encoded by: hsa:56922
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaR r0310
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110058#
is: SBO:0000176

metaM ksii core2 pre4 g
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 4
constant: false
type: Species
is: HMDB00175
is: C00130
has only substance units: false
is: SBO:0000247
notes: FORMULA: C53H86N4O38X CHARGE: -1
boundary condition: false
is: CHEBI:58053

metaM lcts g
is: HMDB00186
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: CHEBI:17716
constant: false
initial amount: NaN
is: SBO:0000247
name: lactose

http://identifiers.org/biomodels.db/MODEL1310110058#_3572dab6_1da4_4124_b223_4509205b655c
is encoded by: hsa:4907
constant: false
is: SBO:0000252
initial amount: NaN
name: NT5E
is: P21589
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR ACGALtly
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
name: N-acetyl-galactosamine lysosomal efflux
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
fast: false
reversible: false

metaR r0683
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110058#
reversible: false
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
modifier: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#

metaR S4TASE3ly
fast: false
modifier: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110058#

metaR r0743
reversible: false
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
type: Reaction
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:

metaR r1613
reversible: true
modifier: MODEL1310110058#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dmnoncoa x
initial amount: NaN
initial concentration: 1.0
name: 4,8 dimethylnonanoyl-CoA
is: HMDB11604
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1

metaM prostgf2 e
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01139
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
is: CHEBI:57404
name: prostaglandin F2alpha(1-)
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_fcfe0320_e46e_4b4c_adfb_a37dea587b56
name: MTMR6
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q9Y217
is encoded by: hsa:9107
has only substance units: false
initial amount: NaN

metaM accoa g
initial amount: NaN
is: CHEBI:57288
type: Species
has only substance units: false
name: acetyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: SBO:0000247

metaM ctp e
has only substance units: false
is: CHEBI:37563
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00082
boundary condition: false
name: CTP(4-)

http://identifiers.org/biomodels.db/MODEL1310110058#_ca3c2546_4cef_41ac_974a_f9c6ce2a3529
type: Species
has only substance units: false
initial concentration: NaN
is: Q96PE7
name: MCEE
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:84693
initial amount: NaN

metaR PROt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
type: Reaction
is: SBO:0000185
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000304
name: L-proline reversible transport via proton symport
reversible: true

metaM accoa n
boundary condition: false
name: acetyl-CoA(4-)
is: HMDB01206
is: SBO:0000247
is: CHEBI:57288
type: Species
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_85fcaac6_1e02_4556_bec5_066a9f44b780
initial amount: NaN
is: Q16881
name: TXNRD1
is encoded by: hsa:7296
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR RE3520E
modifier: MODEL1310110058#
name: RE3520
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.9
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110058#
type: Reaction

metaM zym int2 r
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
name: zymosterol intermediate 2
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:52386

metaM nadph m
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false
is: HMDB00221
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57783
is: SBO:0000247
has only substance units: false

metaM g3pc c
boundary condition: false
is: SBO:0000247
name: sn-Glycero-3-phosphocholine
is: HMDB00086
constant: false
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
type: Species
initial amount: NaN
is: CHEBI:16870
has only substance units: false
initial concentration: 1.0

metaM hdca r
initial amount: NaN
is: C00249
is: HMDB00220
boundary condition: false
is: CHEBI:7896
name: Hexadecanoate (n-C16:0)
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_baf56934_9efe_4d78_8adb_9c986a7041b5
is encoded by: hsa:2954
initial concentration: NaN
name: GSTZ1
constant: false
is: A6NED0
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM lcts e
initial amount: NaN
is: C00243
constant: false
type: Species
is: SBO:0000247
name: Lactose
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
has only substance units: false
is: HMDB00186
is: CHEBI:17716
initial concentration: 1.0

metaR ALCD2yf
fast: false
modifier: MODEL1310110058#
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
is: SBO:0000176
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
kinetic law: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110058#

metaM retinal 11 cis c
name: 11-cis-retinal
is: HMDB02152
is: SBO:0000247
boundary condition: false
is: CHEBI:16066
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

metaR SCPx
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
name: peroxisomal thiolase 2
product: MODEL1310110058#
is: SBO:0000176

metaM betald c
boundary condition: false
has only substance units: false
constant: false
is: HMDB01252
type: Species
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial concentration: 1.0
is: SBO:0000247
name: betaine aldehyde
is: CHEBI:15710
initial amount: NaN

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b528ba16_037d_4ef7_bb13_ef27ac58ee96
name: NDUFC1
is: O43677
boundary condition: true
is encoded by: hsa:4717
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR r1820
reversible: false
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185

metaM prostgf2 c
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: HMDB01139
name: prostaglandin F2alpha(1-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57404
boundary condition: false
type: Species
constant: false

metaM accoa m
is: CHEBI:57288
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
initial concentration: 1.0
is: HMDB01206
is: SBO:0000247
is: C00024
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_10d4f6f2_263e_4700_9c8d_32234f552224
constant: false
type: Species
name: SPHK2
boundary condition: true
is: Q9NRA0
is encoded by: hsa:56848
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM hista c
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0
constant: false
is: CHEBI:58432
name: histamium
initial amount: NaN
boundary condition: false
is: HMDB00870
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_3d72e7c9_e8ed_48c9_85a4_beed5651b4ff
initial concentration: NaN
constant: false
boundary condition: true
is: Q96BD0
is encoded by: hsa:28231
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLCO4A1

metaM ahcys c
is: C00021
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16680
initial concentration: 1.0
constant: false
is: HMDB00939
name: S-Adenosyl-L-homocysteine

metaR r0680
kinetic law: MODEL1310110058#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#

metaR C81CRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_26be3607_d345_4d62_9e62_bce39c9332c3
is: SBO:0000252
initial concentration: NaN
constant: false
name: ABCC5
is encoded by: hsa:10057
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM thym e
is: CHEBI:17821
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00262
initial concentration: 1.0
constant: false
name: thymine
initial amount: NaN
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species

metaM dd3coa x
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: HMDB04257
name: 3-dodecenoylcoa
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false

metaM tetdec2crn e
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H37NO4 CHARGE: 0
name: tetradecadienoyl carnitine
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB05066
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_407ef41e_49e1_4de9_b8f5_8940a9fde3a5
is: SBO:0000252
is: C9JFZ1
name: SYNJ1
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:8867
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_580b3904_000b_452d_85ca_6c935334abdb
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: ATP5F1
boundary condition: true
is encoded by: hsa:515
is: SBO:0000252

metaR DGSNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
fast: false
type: Reaction
product: MODEL1310110058#
name: deoyguanosine transport via diffusion
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000

metaM ppi e
has only substance units: false
type: Species
name: Diphosphate
is: CHEBI:33019
initial concentration: 1.0
is: HMDB00250
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
is: C00013
is: SBO:0000247
initial amount: NaN

metaR r2443
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110058#
fast: false
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
type: Reaction

metaR CYSGLYexR
reactant: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
name: L-cysteine/glycine reversible exchanger
type: Reaction
is described by: ECO:0000000
fast: false

metaM subeac c
name: suberic acid
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00893
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C8H12O4 CHARGE: -2

metaR DOLPMT2 Ler
is: SBO:0000176
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
fast: false

metaR ILEtec
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
product: MODEL1310110058#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
name: L-isoleucine transport via diffusion (extracellular to cytosol)
fast: false

metaM 2oxoadp c
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 2-oxoadipate(2-)
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
constant: false
is: CHEBI:57499
is: HMDB00225
boundary condition: false
initial concentration: 1.0

metaM hista e
is: CHEBI:58432
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
name: histamium
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
constant: false
is: HMDB00870
is: SBO:0000247

metaM ahcys e
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
is: CHEBI:16680
type: Species
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00939
initial amount: NaN
is: C00021

metaR CBASPte
fast: false
product: MODEL1310110058#
name: Transport of N-carbamoyl-L-aspartate
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110058#
type: Reaction

metaR r0747
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is: SBO:0000176
modifier: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
reversible: true
product: MODEL1310110058#

metaM thym c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: Thymine
boundary condition: false
is: C00178
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: CHEBI:17821
is: HMDB00262
has only substance units: false
is: SBO:0000247

metaR PRISTtx
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: true
product: MODEL1310110058#
name: prist peroxisomal transport
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_85171cf5_592a_4e65_bf4d_a88a426d4252
boundary condition: true
is encoded by: hsa:AI972237
constant: false
initial amount: NaN
name: _AI972237_1_c
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR M7MASNBterg
type: Reaction
is: SBO:0000185
reactant: MODEL1310110058#
reversible: false
is described by: ECO:0000000
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD

metaR r1384
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
reactant: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000176
type: Reaction

metaM dump c
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: CHEBI:246422
constant: false
is: SBO:0000247
name: dUMP
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01409
is: C00365
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_0322d07e_3b24_4181_8d01_d45d51210bf1
initial amount: NaN
is encoded by: hsa:9469
is: SBO:0000252
name: CHST3
boundary condition: true
constant: false
type: Species
has only substance units: false
is: Q7LGC8
initial concentration: NaN

metaR DURAD2
reversible: true
is: SBO:0000176
name: dihydrothymin dehydrogenase (NADP)
type: Reaction
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.1.2
is described by: ECO:0000269

metaR ECOAH1m
fast: false
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110058#
is described by: ECO:0000304
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR NBAHH ir
type: Reaction
notes: GENE_ASSOCIATION: (84735.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES:NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human
reversible: false
kinetic law: MODEL1310110058#
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
modifier: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.4.13.20
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_b0ca1216_58ee_46ca_aa72_6102502dde9f
boundary condition: true
has only substance units: false
is: Q9Y6M9
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: NDUFB9
is encoded by: hsa:4715
constant: false

metaR r1381
is described by: ECO:0000000
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000176
reactant: MODEL1310110058#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
product: MODEL1310110058#
reversible: true
type: Reaction
fast: false

metaM tchola e
name: taurocholic acid
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00036
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR r2332
is: SBO:0000185
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110058#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_0d806368_da94_45a4_94e1_c540cb2d689c
constant: false
has only substance units: false
boundary condition: true
is: P43155
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1384
initial concentration: NaN
name: CRAT

metaM ksi pre20 g
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 20
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_cfd649a6_e457_4182_ab4e_6373283f8215
initial amount: NaN
has only substance units: false
name: SGMS1
is: D3DWC4
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:259230

metaM dhcholestanate c
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
initial concentration: 1.0
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_e8e06a48_d762_43b2_b5e1_1f3944c33da9
initial amount: NaN
is: SBO:0000252
is: Q9NQR4
boundary condition: true
name: NIT2
is encoded by: hsa:56954
initial concentration: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_5582d37c_7072_4f04_b6db_e453a59036b5
initial amount: NaN
boundary condition: true
name: LTA4H
is: P09960
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4048
is: SBO:0000252
constant: false
type: Species

metaR STRDNCt
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110058#
product: MODEL1310110058#

metaM tetdec2crn c
type: Species
initial amount: NaN
is: HMDB02014
constant: false
is: SBO:0000247
notes: FORMULA: C21H37NO4 CHARGE: 0
name: tetradecadienoyl carnitine
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR ACGAMK
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.59
name: N-acetylglucosamine kinase
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_1a0a2414_803a_4f8e_927b_30c0f1bb6f6a
initial concentration: NaN
is encoded by: hsa:3074
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: HEXB
is: SBO:0000252
is: P07686

metaR G14T17g
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110058#
is: SBO:0000176

metaR r2331
product: MODEL1310110058#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110058#
is described by: ECO:0000000

metaM fum c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false
is: HMDB00134
is: SBO:0000247
is: CHEBI:29806
boundary condition: false
type: Species
initial amount: NaN
is: C00122
name: Fumarate

http://identifiers.org/biomodels.db/MODEL1310110058#_7eb6b4f4_4082_433b_9208_0a27d9496d1e
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: B3KT70
name: HKDC1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:80201
initial amount: NaN

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR TDPm
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
name: thiamin pyrophosphatase, mitochondrial

metaR RE2759X
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
reactant: MODEL1310110058#
name: RE2759
fast: false
is version of: http://identifiers.org/ec-code/5.1.99.4
kinetic law: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
type: Reaction

metaR r1902
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110058#_ee8e9a0d_9268_4516_8339_33b3b7f5877f
initial concentration: NaN
is encoded by: hsa:5372
is: A8K003
boundary condition: true
has only substance units: false
constant: false
name: PMM1
type: Species
initial amount: NaN
is: SBO:0000252

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_0c0a1573_3bd4_4947_8bb5_001766dd1568
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: ATP5J
is encoded by: hsa:522
boundary condition: true
is: SBO:0000252

metaM asp L c
is: SBO:0000247
is: HMDB00191
has only substance units: false
is: CHEBI:29991
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR SERCYSNaEx
reactant: MODEL1310110058#
reversible: false
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110058#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
kinetic law: MODEL1310110058#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

metaM 13 cis retn r
constant: false
is: D00348
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB06219
name: 13-cis-retinoate
is: http://identifiers.org/pubchem.compound/7847414
initial amount: NaN

metaR r0463
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_4fe4d059_e5f8_48c8_96c9_1800eb949ba0
type: Species
name: AADAT
is encoded by: hsa:51166
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q8N5Z0
initial amount: NaN
has only substance units: false

metaR CYOR u10m
is: SBO:0000185
name: ubiquinol-6 cytochrome c reductase, Complex III
fast: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110058#

metaM tchola c
boundary condition: false
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
name: taurocholic acid
initial amount: NaN
is: HMDB00036
is: SBO:0000247
is: CHEBI:36257
constant: false
initial concentration: 1.0

metaR r2334
reactant: MODEL1310110058#
type: Reaction
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110058#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185

metaR TTDCAFATPc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR r1492
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
reversible: false
fast: false
name: Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_324d753c_bd12_49f7_9860_ea4efbf899d7
type: Species
is: SBO:0000252
is: Q05C14
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: FOLR3
is encoded by: hsa:2352
boundary condition: true

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM lnlccoa c
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: HMDB01064

metaM ksii core2 pre10 g
constant: false
is: SBO:0000247
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
has only substance units: false
type: Species
name: keratan sulfate II biosynthesis, precursor 10
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110058#_533e15cf_0c71_4265_92d6_6828eb139b40
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: _H45672_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:H45672

metaM dmpp x
type: Species
name: prenyl diphosphate(3-)
constant: false
is: HMDB01120
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57623
is: SBO:0000247
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235

http://identifiers.org/biomodels.db/MODEL1310110058#_6e052ef5_886c_49ad_b696_fc8ed66d5f09
initial concentration: NaN
constant: false
is: Q11203
is encoded by: hsa:6487
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110058#_3c5dff5b_2cbb_4fdb_9e7f_c85df32d52dd
name: GUSB
is: P08236
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:2990
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_4bfc29ec_0a44_4828_9227_07b47e02a570
boundary condition: true
is: SBO:0000252
has only substance units: false
is: O95395
type: Species
is encoded by: hsa:9245
constant: false
name: GCNT3
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_8b4107e6_4f9d_454f_9d42_d644501a40ef
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: _LOC728997_1_c
is encoded by: hsa:LOC728997

metaM crn c
boundary condition: false
is: C00318
initial concentration: 1.0
is: SBO:0000247
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
name: L-Carnitine
is: CHEBI:16347
initial amount: NaN
has only substance units: false
type: Species

metaR r2333
is: SBO:0000185
product: MODEL1310110058#
type: Reaction
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM HC00342 m
name: cis-aconitate(3-)
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
boundary condition: false
is: CHEBI:16383
type: Species
is: SBO:0000247

metaR FAOXC2251836m
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
name: Beta oxidation of fatty acid
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR r1493
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
product: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
reversible: false
fast: false
name: Utilized transport

metaR r1380
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_b0175905_a77a_4e76_887f_87f28c84226f
is: SBO:0000252
has only substance units: false
is: Q9GZS9
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:23563
boundary condition: true
name: CHST5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_8e70a755_8fcb_45d7_b230_544fdba8128f
boundary condition: true
constant: false
has only substance units: false
is: Q86YW0
is: SBO:0000252
initial concentration: NaN
name: PLCZ1
type: Species
is encoded by: hsa:89869
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_3e8aaf3b_aa23_44d3_a08e_2f18f6b33d42
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: BPNT1
constant: false
type: Species
is: O95861
is encoded by: hsa:10380

metaR r0317
is described by: ECO:0000000
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_2e6a168b_72fa_4d05_8006_839bfa4af75d
is encoded by: hsa:645
has only substance units: false
name: BLVRB
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is: P30043

http://identifiers.org/biomodels.db/MODEL1310110058#_8115e814_6e57_48db_8f33_6680b2928d3e
constant: false
is encoded by: hsa:509
is encoded by: hsa:498
has part: Q6I9V2
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
has only substance units: false
type: Species
has part: P25705

metaR GGLUCT
is version of: http://identifiers.org/ec-code/2.3.2.4
fast: false
product: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
reversible: false
name: gamma-glutamylcyclotransferase
kinetic law: MODEL1310110058#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110058#_3563f83c_f9f3_42cc_bb02_78a53dfd9ac2
is encoded by: hsa:3418
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: IDH2
is: P48735

metaR r0974
product: MODEL1310110058#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_d7ae03b8_9df4_4b1c_b5ae_24d56d916e0a
constant: false
boundary condition: true
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:7991
initial amount: NaN
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110058#_14f837e0_434c_476e_93e5_cdbb71f0f57e
is: SBO:0000297
is encoded by: hsa:3030
boundary condition: true
is encoded by: hsa:3032
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: HADHA:HADHB
has part: E9KL44
has part: P55084

metaR FAOXC80
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
name: Beta oxidation of med/long chain fatty acid
is described by: ECO:0000269
reversible: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM ksi pre28 g
boundary condition: false
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: C00130
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 28
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:58053
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_4b3f3874_e7b2_4169_ad83_8d1e791333d1
has only substance units: false
is: F8VQS7
name: NDUFA12
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:55967
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_b988bcac_a364_4a5a_a09f_9ef44e0d18b5
type: Species
name: _AI222095_1_e
has only substance units: false
boundary condition: true
is encoded by: hsa:AI222095
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaM ppi n
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:33019
name: diphosphate(3-)

metaM crn e
constant: false
type: Species
is: HMDB00062
is: CHEBI:16347
has only substance units: false
initial amount: NaN
name: L-Carnitine
initial concentration: 1.0
is: C00318
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_b2438d83_5ee2_4589_82ec_215d7f5bd0f2
name: ELOVL2
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q9NXB9
has only substance units: false
is encoded by: hsa:54898
constant: false

metaM glcur l
constant: false
is: HMDB00127
has only substance units: false
name: D-glucuronate
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR r0464
product: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_54299702_8c9e_4526_997d_0f9de1ee316f
initial concentration: NaN
name: ABCC4
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: O15439
is: SBO:0000252
is encoded by: hsa:10257

metaR r0311
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110058#
product: MODEL1310110058#

metaR r0973
reversible: true
is described by: ECO:0000000
name: Facilitated diffusion
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110058#
fast: false
type: Reaction
product: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_df0d95ef_fa23_4d5f_8ce3_69c04299f984
boundary condition: true
is: F5GZG6
has only substance units: false
constant: false
is encoded by: hsa:27010
is: SBO:0000252
initial concentration: NaN
name: TPK1
initial amount: NaN
type: Species

metaR METS
modifier: MODEL1310110058#
reversible: false
name: methionine synthase
product: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.13
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000134
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y

metaM ppa c
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
initial amount: NaN
name: propionate
has only substance units: false
is: SBO:0000247
is: HMDB00237
boundary condition: false
type: Species
is: CHEBI:17272
constant: false

metaR r0688
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reversible: true
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
product: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR BHBtm
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
kinetic law: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV

metaM 4fumacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: HMDB01268
has only substance units: false
name: 4-fumarylacetoacetate(2-)
is: CHEBI:18034
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_61e45a12_5975_4314_ad50_fb2e5414c459
type: Species
is: SBO:0000252
name: _206_1_c
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:206
constant: false
has only substance units: false

metaR r2330
fast: false
kinetic law: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: true
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_1cdf67a3_fbb5_451a_aa11_b7f995f4dbdb
constant: false
is encoded by: hsa:518
initial concentration: NaN
name: ATP5G3
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaM tetpent3coa c
boundary condition: false
is: C16167
type: Species
initial concentration: 1.0
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
constant: false
name: tetracosapentaenoyl coenzyme A, n-3
has only substance units: false
is: SBO:0000247

metaM ppi m
is: CHEBI:33019
is: C00013
name: Diphosphate
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00250
has only substance units: false
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false

metaR RE2649M
fast: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
name: RE2649
is described by: ECO:0000000
modifier: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_13edd2f5_f058_43e2_a8b7_8f55f67285d2
is: Q5TDP6
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:51557
boundary condition: true
name: LGSN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_8ddc6047_735d_4c23_b0c9_485a6c4ba0b6
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:85365
is: SBO:0000252
constant: false
name: ALG2

metaM q10h2 m
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
type: Species
is: HMDB13111
name: Ubiquinol-10
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

metaR LCADi
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110058#
name: lactaldehyde dehydrogenase
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110058#

metaR LNLNCAt
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110058#
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false

metaM prostgd2 r
type: Species
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial concentration: 1.0
is: HMDB01403
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57406
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_991b8c84_9e41_4f05_a859_c697c8d8ad63
name: SLC4A5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57835
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR r0975
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110058#
product: MODEL1310110058#
name: Facilitated diffusion
reactant: MODEL1310110058#
is: SBO:0000185
reversible: false
is described by: ECO:0000000

metaM cs e deg1 l
initial concentration: 1.0
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
is: CHEBI:57737
initial amount: NaN
is: HMDB00868
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
type: Species

metaM ppa e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
is: HMDB00237
name: propionate
has only substance units: false
is: CHEBI:17272
constant: false
type: Species
boundary condition: false

metaM sebacid x
boundary condition: false
is: SBO:0000247
is: C08277
type: Species
is: HMDB00792
notes: FORMULA: C10H16O4 CHARGE: -2
constant: false
has only substance units: false
name: sebacicacid
initial concentration: 1.0
initial amount: NaN

metaM 2oxoadp m
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
name: 2-oxoadipate(2-)
is: CHEBI:57499
constant: false
is: HMDB00225
initial concentration: 1.0
is: SBO:0000247

metaR O2St
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (extracellular)
reversible: true
fast: false

metaR MG1er
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110058#
product: MODEL1310110058#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/3.2.1.106
reactant: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110058#

metaR H2O2t
reversible: true
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
name: hydrogen peroxide transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF

metaR ARACHCRNt
reactant: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
is: SBO:0000185
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_232116bc_3ad0_40ed_8e41_e1ca6dc71278
type: Species
is: Q8NEM3
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9194
has only substance units: false
name: SLC16A7

metaR A4GALTg
is: SBO:0000176
type: Reaction
reversible: false
name: Lactosylceramide 4-alpha-galactosyltransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.228
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
reactant: MODEL1310110058#

metaR PHCDm
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is described by: ECO:0000304
product: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110058#

metaR FAOXC61C4m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM Rtotal3 c
notes: FORMULA: CO2FULLR3 CHARGE: -1
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:16189
is: HMDB01448
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: R total 3 position

http://identifiers.org/biomodels.db/MODEL1310110058#_04a553d3_8d6c_4add_9026_6b6e6164e3b6
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9H845
name: ACAD9
is: SBO:0000252
constant: false
is encoded by: hsa:28976
type: Species

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaM dcdp m
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01245
name: dCDP(3-)
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
boundary condition: false
is: CHEBI:58593
constant: false

metaR r0242
product: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.1
fast: false
modifier: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
reversible: true

metaM ppi r
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Diphosphate
is: HMDB00250
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_12530034_1864_4f9f_9b72_146f1f8256f1
name: ATP1B2
is: SBO:0000252
is encoded by: hsa:482
constant: false
is: P14415
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaM octa c
name: octanoate (n-C8:0)
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H15O2 CHARGE: -1
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:25646
is: C06423
is: HMDB00482

http://identifiers.org/biomodels.db/MODEL1310110058#_82f28f88_1b40_4626_92ee_9b7bd9204abc
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AF080579
constant: false
has only substance units: false
name: _AF080579_1_c
boundary condition: true
initial concentration: NaN
type: Species

metaR PI5P3K
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.154
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.137
fast: false
kinetic law: MODEL1310110058#

metaR ALR3
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
modifier: MODEL1310110058#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: aldose reductase (acetol)
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_65819381_801d_4172_a0ff_d346b676592c
initial amount: NaN
initial concentration: NaN
constant: false
is: Q86YI5
is encoded by: hsa:1737
name: DLAT
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_f676fcb2_64a7_4b6f_bd87_3150ceb75ceb
has only substance units: false
initial amount: NaN
is encoded by: hsa:509
is: SBO:0000252
is: Q6I9V2
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: ATP5C1

http://identifiers.org/biomodels.db/MODEL1310110058#_6efa71dd_394f_4510_9867_c3ce1de6715d
is encoded by: hsa:509
constant: false
type: Species
initial concentration: NaN
name: ATP5C1
is: P36542
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR PDHm
is version of: http://identifiers.org/ec-code/1.2.4.1
fast: false
kinetic law: MODEL1310110058#
is described by: ECO:0000134
name: pyruvate dehydrogenase
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
is version of: http://identifiers.org/ec-code/2.3.1.12
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.8.1.4

http://identifiers.org/biomodels.db/MODEL1310110058#_e12402a3_cb7d_4e84_a0ec_66220e30f990
type: Species
is: B2R6S5
name: CMPK1
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:51727
initial amount: NaN
initial concentration: NaN

metaR ACGAM6PSi
reactant: MODEL1310110058#
name: N-acetylglucosamine-6-phosphate synthase
kinetic law: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.4
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000304
is: SBO:0000176
fast: false
type: Reaction

metaR PEAMNO
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.4.3.21
type: Reaction
reversible: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
name: Phenethylamine oxidase
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.22

metaR AKR1D2
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
fast: false
reversible: false
modifier: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.1.3
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is: SBO:0000176
product: MODEL1310110058#
is described by: ECO:0000269

metaM malt e
is: HMDB00163
type: Species
is: SBO:0000247
is: C00208
initial concentration: 1.0
is: CHEBI:17306
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
constant: false
has only substance units: false
initial amount: NaN
name: Maltose

metaR ALR2
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110058#
name: aldose reductase (methylglyoxal)
is version of: http://identifiers.org/ec-code/1.1.1.2

metaR RE1518M
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
name: RE1518
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110058#
type: Reaction
reversible: true
is: SBO:0000176

metaR FAOXC204C184m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaM Rtotal3 e
type: Species
name: R total 3 position
notes: FORMULA: CO2FULLR3 CHARGE: -1
boundary condition: false
is: HMDB00244
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:3554
is: SBO:0000247
constant: false
is: C00255

http://identifiers.org/biomodels.db/MODEL1310110058#_96ee40cf_ec7d_404f_93f4_f712a26f6591
boundary condition: true
constant: false
is: SBO:0000297
has only substance units: false
initial concentration: NaN
initial amount: NaN
has part: Q92536
name: SLC3A2:SLC7A6
type: Species
is encoded by: hsa:9057

metaM thcholstoic r
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB03873
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

metaM leuktrC4 e
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
name: leukotriene C4(2-)
is: HMDB01198
is: CHEBI:57973
has only substance units: false
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247

metaM 3hmbcoa m
initial amount: NaN
is: HMDB01356
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
type: Species
is: CHEBI:57312
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_2755cea3_e446_44d3_9fa6_03622268da7e
type: Species
constant: false
name: _AU149534_1_m
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AU149534
initial amount: NaN
has only substance units: false
boundary condition: true

metaM crn m
is: C00318
constant: false
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
name: L-Carnitine
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:16347
initial concentration: 1.0
boundary condition: false

metaM dhcholestanate m
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: HMDB00359
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
is: SBO:0000247
initial concentration: 1.0

metaR r0245
is: SBO:0000176
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false

metaM dcdp n
boundary condition: false
name: dCDP(3-)
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
is: CHEBI:58593
initial concentration: 1.0
constant: false
is: HMDB01245
type: Species
initial amount: NaN

metaM dump n
constant: false
is: HMDB01409
initial amount: NaN
type: Species
is: CHEBI:246422
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
name: dUMP(2-)
has only substance units: false

metaM C05279 m
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
initial concentration: 1.0
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: SBO:0000247
is: HMDB11123
type: Species
initial amount: NaN
is: CHEBI:28387

metaR ST8SIA11
kinetic law: MODEL1310110058#
name: Beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.8
modifier: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
type: Reaction
fast: false
product: MODEL1310110058#
is: SBO:0000176

metaM xu5p D c
is: CHEBI:57737
name: D-xylulose 5-phosphate(2-)
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00868
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
type: Species
boundary condition: false

metaM ptth m
is: SBO:0000247
constant: false
is: HMDB03426
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:16753
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831

http://identifiers.org/biomodels.db/MODEL1310110058#_5bed8409_fea6_41b0_a059_d5b9b6cf586d
constant: false
has only substance units: false
name: SKIV2L2
is: Q3MHC9
is encoded by: hsa:23517
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_adc0b385_c17f_4a4e_b765_c1b1d60bcd57
name: _7359_1_c
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:7359
boundary condition: true

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM HC01409 m
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: Hexanoyl-CoA
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: CHEBI:27540

metaR r2335
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR ST8SIA12
product: MODEL1310110058#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110058#
name: Beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110058#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.8
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is: SBO:0000176

metaM abt c
initial amount: NaN
is: SBO:0000247
is: CHEBI:18403
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851
name: L-arabinitol
initial concentration: 1.0
constant: false

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR r0246
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110058#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2

metaM thcholstoic x
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
is: CHEBI:18402
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
is: HMDB03873
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_d1d331c4_3608_4dce_83a4_e67aaaf30bac
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9BXS1
constant: false
has only substance units: false
is encoded by: hsa:91734
boundary condition: true
type: Species
name: IDI2

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_f0fe1f5e_13ca_4ba9_9e94_9cc41d4a1dd3
name: AK7
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q96M32
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:122481

metaM dgdp m
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
initial amount: NaN
is: SBO:0000247
name: dGDP(2-)
is: CHEBI:58595
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

metaM hx2coa m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: trans-Hex-2-enoyl-CoA
is: HMDB06870
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C05998
is: http://identifiers.org/pubchem.compound/11966188
type: Species

metaM ppa m
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:17272
is: SBO:0000247
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
initial concentration: 1.0
has only substance units: false
constant: false
name: propionate

http://identifiers.org/biomodels.db/MODEL1310110058#_d5d7e461_6633_4e17_ad51_36db9166a8a5
is encoded by: hsa:10846
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: Q9Y233
name: PDE10A
type: Species
initial concentration: NaN
has only substance units: false

metaM asp L e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:29991
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
constant: false
is: HMDB00191

http://identifiers.org/biomodels.db/MODEL1310110058#_801a04df_0bc1_43be_9801_102b8badf6de
initial amount: NaN
has part: B7Z9T9
is encoded by: hsa:5158
is encoded by: hsa:5145
constant: false
is encoded by: hsa:5149
type: Species
initial concentration: NaN
has only substance units: false
has part: Q13956
name: PDE6A:PDE6H:PDE6B
has part: P16499
is: SBO:0000297
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_61e28b8f_00f6_4c8f_a264_36aa7d002c33
is encoded by: hsa:79053
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ALG8
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_fb0e143c_cb76_44ea_98f5_0cc189b36413
is: P34059
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:2588
name: GALNS
is: SBO:0000252
constant: false

metaR FAH1
notes: GENE_ASSOCIATION: (1579.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11996015,PMID:7679927,PMID:8274222 NOTES:fatty acid hydroxylation NJ
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.15.3
product: MODEL1310110058#
fast: false
reversible: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Fatty acid omega-hydroxylase
type: Reaction

metaM glygn5 e
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB00131
is: CHEBI:17754
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C12H21O11X CHARGE: 0
is: C00116

http://identifiers.org/biomodels.db/MODEL1310110058#_134a3f0f_4278_47e9_a551_b430aa91fee6
constant: false
is encoded by: hsa:483
initial concentration: NaN
type: Species
is: P54709
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ATP1B3

metaR ACOAD8m
product: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.10
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
fast: false

metaM thbpt4acam n
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
is: CHEBI:15374
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02281
constant: false
boundary condition: false

metaM dgdp n
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
initial concentration: 1.0
is: CHEBI:58595
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: dGDP(2-)

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_1e09f186_98e7_413b_bbcd_cf28ad05b32b
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8654
name: PDE5A
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaM 5fthf m
initial amount: NaN
name: 5-formyltetrahydrofolate(2-)
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
constant: false
type: Species
is: CHEBI:57457
is: HMDB01562
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM octa e
initial amount: NaN
name: octanoate (n-C8:0)
constant: false
type: Species
has only substance units: false
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646
is: SBO:0000247
is: HMDB00482
boundary condition: false
is: C06423
initial concentration: 1.0

metaM abt e
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403
constant: false
name: L-arabinitol
is: SBO:0000247
type: Species
is: HMDB01851
initial amount: NaN
initial concentration: 1.0

metaM fum m
is: C00122
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: CHEBI:29806
name: Fumarate
is: HMDB00134
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_b4579c37_1a4c_45ae_9cfc_eb43b965d346
initial amount: NaN
is encoded by: hsa:644
is: P53004
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: BLVRA
type: Species
is: SBO:0000252

metaR r0249
type: Reaction
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.7.12
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
reversible: true
modifier: MODEL1310110058#
is: SBO:0000176

metaR r2338
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reactant: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_a114b867_d48e_4a7a_9f86_1b6b7f2dcd75
boundary condition: true
is encoded by: hsa:6517
is: SBO:0000252
name: SLC2A4
initial concentration: NaN
is: P14672
initial amount: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_3d26a4a4_5f92_4197_aeed_61565263c84e
type: Species
constant: false
name: SLC27A2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11001
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O14975

metaM dhcholestanate r
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: SBO:0000247
is: HMDB00359
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_c43c9f6b_c7d3_4624_b6a0_4f8b92661f3d
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9NYQ3
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:51179
initial amount: NaN
name: HAO2

metaR RDH3a
fast: false
product: MODEL1310110058#
type: Reaction
name: retinol dehydrogenase (11-cis,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.300
reversible: true
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_215203b4_938f_4f11_8d5e_c0518b657cce
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5743
is: P35354
initial amount: NaN
name: PTGS2
constant: false
boundary condition: true
type: Species

metaR GTMLTe
type: Reaction
reversible: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.2.2
is: SBO:0000185
name: g-glutamyltransferase (e)
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000269

metaR r2444
type: Reaction
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110058#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_d24bfcfc_f001_4999_b422_f8fd3d680446
name: SULT1A2
boundary condition: true
is: P50226
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6799
is: SBO:0000252
initial concentration: NaN

metaR r0527
kinetic law: MODEL1310110058#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
is: SBO:0000176
product: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is described by: ECO:0000000
fast: false
reversible: true

metaR FACOAL203
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000176
reversible: true
modifier: MODEL1310110058#
product: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110058#
name: fatty-acid--CoA ligase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM guln r
type: Species
constant: false
has only substance units: false
is: HMDB03290
initial amount: NaN
is: SBO:0000247
is: CHEBI:13115
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
boundary condition: false
name: L-gulonate
initial concentration: 1.0

metaM dhap x
boundary condition: false
is: HMDB01473
is: C00111
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: Dihydroxyacetone phosphate
is: SBO:0000247
is: CHEBI:57642

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

metaR PTE3x
kinetic law: MODEL1310110058#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110058#
name: peroxisomal acyl-CoA thioesterase
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.2.2

metaM acmanap c
type: Species
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
is: HMDB01121
has only substance units: false
is: SBO:0000247
name: N-acetyl-D-mannosamine 6-phosphate(2-)
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58557
initial concentration: 1.0

metaM crn r
is: SBO:0000247
is: HMDB00062
initial amount: NaN
has only substance units: false
is: CHEBI:16347
constant: false
name: (R)-carnitine
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
boundary condition: false

metaR r1607
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110058#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110058#_65e35f12_bfe5_47dc_a364_0c6e0a51b4ad
constant: false
is: Q13956
is encoded by: hsa:5149
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PDE6H

http://identifiers.org/biomodels.db/MODEL1310110058#_d1a35f5c_4f12_43ee_ada5_c5e375734fc2
initial concentration: NaN
boundary condition: true
name: SLC6A9
has only substance units: false
is: SBO:0000252
is: P48067
initial amount: NaN
is encoded by: hsa:6536
constant: false
type: Species

metaR DHCR72r
name: 7-dehydrocholesterol reductase
fast: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.1.21
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_be26a9ce_3857_4a91_b627_ae9a53866975
is encoded by: hsa:411
name: ARSB
boundary condition: true
is: A8K4A0
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR CHOLESTle
is version of: http://identifiers.org/ec-code/3.1.1.13
reactant: MODEL1310110058#
fast: false
type: Reaction
reversible: false
product: MODEL1310110058#
is described by: ECO:0000134
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: hydrolysis of cholesterol ester by cholesterol esterase
modifier: MODEL1310110058#
is: SBO:0000176

metaM 4ppan c
is: CHEBI:10986
name: D-4'-Phosphopantothenate
boundary condition: false
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
initial concentration: 1.0
is: HMDB01016
type: Species
initial amount: NaN
is: C03492
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_87672f7b_6180_42b0_9739_8afe7e947c07
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8503
name: PIK3R3
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q92569

metaR r0750
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
modifier: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#

metaM CE5120 m
name: trans-2-cis-8-tetradecadienoyl-CoA
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial concentration: 1.0
boundary condition: false
is: CHEBI:57923

metaM ctp m
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
name: CTP(4-)
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00082
is: CHEBI:37563
constant: false
boundary condition: false
is: SBO:0000247

metaR FACOAL204
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
type: Reaction
reversible: true
modifier: MODEL1310110058#
name: fatty-acid--CoA ligase
is: SBO:0000176
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
fast: false
product: MODEL1310110058#

metaM 7thf e
is: HMDB06559
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C49H57N13O24 CHARGE: -8
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: heptaglutamyl folate (THF)

metaR r1606
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185
fast: false

metaM dcdp c
boundary condition: false
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
type: Species
is: C00705
is: SBO:0000247
constant: false
name: dCDP
is: CHEBI:58593
has only substance units: false
initial concentration: 1.0

metaR ADAe
is described by: ECO:0000269
product: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
name: Adenosine deaminase, extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_b66c97f9_f8c2_4f3b_b874_aca6127ff77e
is: P30084
has only substance units: false
type: Species
name: ECHS1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1892
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_59b65574_f4b2_4dfe_8337_e1f3149acc2d
is encoded by: hsa:U37519
boundary condition: true
type: Species
initial concentration: NaN
name: _U37519_1_c
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaR FACOAL205
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110058#
name: fatty-acid--CoA ligase
reactant: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true

metaM 5oxpro c
boundary condition: false
is: CHEBI:57606
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
initial amount: NaN
name: 5-oxoprolinate
is: HMDB00267
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaM prostgd2 e
is: HMDB01403
boundary condition: false
name: prostaglandin D2(1-)
initial concentration: 1.0
is: CHEBI:57406
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_537f6ef1_247a_4684_a0d0_92962a07ce86
has only substance units: false
boundary condition: true
is: P23786
name: CPT2
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:1376

metaR r1609
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110058#

metaM ctp n
name: CTP(4-)
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
initial concentration: 1.0
is: HMDB00082
constant: false
is: SBO:0000247
is: CHEBI:37563

metaM ppi x
is: SBO:0000247
is: CHEBI:33019
has only substance units: false
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00250
type: Species

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaM sebacid c
constant: false
notes: FORMULA: C10H16O4 CHARGE: -2
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00792
is: C08277
is: SBO:0000247
name: sebacicacid
type: Species
initial amount: NaN

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaR THMPPtm
reactant: MODEL1310110058#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
product: MODEL1310110058#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110058#
type: Reaction
name: Thiamine diphosphate transport in via anion antiport, mitochondria

http://identifiers.org/biomodels.db/MODEL1310110058#_f5de09fb_baef_44bd_a5c7_67f5325a24ce
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:27430
boundary condition: true
constant: false
name: MAT2B
type: Species
initial amount: NaN

metaM 5oxpro e
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
initial amount: NaN
is: CHEBI:57606
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 5-oxoprolinate
is: HMDB00267
is: SBO:0000247

metaR PGISr
type: Reaction
reversible: true
fast: false
name: Prostaglandin I2 synthase
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/5.3.99.4
reactant: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110058#_b82b15b3_851a_4912_ab94_3cc8e7118ba5
is: SBO:0000252
is: B3KQH0
name: SLC35C1
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:55343
has only substance units: false

metaR FAOXC181C161x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR r1608
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
fast: false

metaR XYLt
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
kinetic law: MODEL1310110058#
type: Reaction
is: SBO:0000185
name: D-xylose reversible transport
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_db8e52ca_24c0_486a_bb24_ef16315a3489
constant: false
is encoded by: hsa:4905
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P46459
type: Species
name: NSF
has only substance units: false

metaR DITPtn
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
name: dITP nuclear transport
is: SBO:0000185
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_5b901917_006c_497c_a537_5a587638715c
has only substance units: false
initial amount: NaN
name: KL
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9365
constant: false
is: Q9UEF7
boundary condition: true

metaM leuktrC4 c
has only substance units: false
name: leukotriene C4(2-)
constant: false
is: CHEBI:57973
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

metaR r0753
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000176
modifier: MODEL1310110058#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110058#
reversible: true
type: Reaction
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_ead12650_7d08_4d71_a73b_6049ce14041f
is encoded by: hsa:2983
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000297
initial concentration: NaN
name: GUCY1A2:GUCY1B3
has part: P33402
has part: Q02153
is encoded by: hsa:2977
initial amount: NaN

metaM cs e deg3 l
boundary condition: false
initial concentration: 1.0
is: CHEBI:15748
constant: false
initial amount: NaN
notes: FORMULA: C37H53NO44S4 CHARGE: -6
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110058#_dd8d6e78_c6c9_4271_9d68_5502d6a69372
has part: P15531
boundary condition: true
has part: P22392
is encoded by: hsa:4831
is: SBO:0000297
has only substance units: false
constant: false
name: NME1:NME2
is encoded by: hsa:4830
type: Species
initial concentration: NaN
initial amount: NaN

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaR GGH 10FTHF5GLUe
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
reactant: MODEL1310110058#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

metaM ptth e
is: CHEBI:16753
initial amount: NaN
boundary condition: false
name: pantetheine
initial concentration: 1.0
is: HMDB03426
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1

metaM sbt D c
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:17924
is: HMDB00247
boundary condition: false
initial concentration: 1.0
name: D-glucitol
is: SBO:0000247

metaM prostgd2 c
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57406
is: HMDB01403
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
name: prostaglandin D2(1-)

metaR r1603
kinetic law: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM dgdp c
is: HMDB00960
is: C00361
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:58595
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM betald m
has only substance units: false
is: HMDB01252
initial amount: NaN
is: SBO:0000247
name: betaine aldehyde
is: CHEBI:15710
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR RE1796M
is: SBO:0000176
type: Reaction
reversible: true
name: RE1796
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_8f79214d_8818_42d7_8502_b17833242f19
constant: false
is: Q9BZQ4
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: NMNAT2
is encoded by: hsa:23057
boundary condition: true
is: SBO:0000252

metaR GAPD
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.12
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
product: MODEL1310110058#
reversible: true
is described by: ECO:0000134
name: glyceraldehyde-3-phosphate dehydrogenase
modifier: MODEL1310110058#

metaM HC00342 c
type: Species
name: cis-aconitate(3-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16383

metaM dhcholestanate x
is: HMDB00359
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR FAOXC16BRx
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR PAIL HStn
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol nuclear transport (diffusion)
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_76a6371e_a71b_491f_9eb4_815366ba6104
type: Species
is: A8K596
boundary condition: true
has only substance units: false
is encoded by: hsa:1757
name: SARDH
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaR G14T8g
type: Reaction
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false

metaM fad c
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
constant: false
boundary condition: false
is: HMDB01248

metaR r1602
kinetic law: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true
product: MODEL1310110058#

metaM 6pgc r
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
is: CHEBI:58759
is: HMDB01316
initial amount: NaN
has only substance units: false
name: 6-phosphonatooxy-D-gluconate

metaM thym m
type: Species
is: HMDB00262
name: thymine
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
has only substance units: false
is: CHEBI:17821
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM 3hexdtetcoa m
initial amount: NaN
type: Species
has only substance units: false
name: 3,7,10,13-hexadecatetraenoylcoa
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02288

metaR FACOAL200
type: Reaction
fast: false
product: MODEL1310110058#
modifier: MODEL1310110058#
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR r0754
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#

metaR C5DCe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM ptth c
has only substance units: false
is: HMDB03426
constant: false
type: Species
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
is: CHEBI:16753
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM sbt D e
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
is: HMDB00247
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: D-glucitol

metaR RE3273C
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000000
name: RE3273
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#

metaM trdrd c
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:15967
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
is: C00342
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM accoa c
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:57288
initial amount: NaN
name: Acetyl-CoA
is: C00024

metaR r1605
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_cd6d3172_8b3f_45ca_8251_dbf88916625a
is encoded by: hsa:4121
is: P33908
is: SBO:0000252
initial amount: NaN
name: MAN1A1
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true

metaM crn x
initial concentration: 1.0
is: SBO:0000247
name: L-Carnitine
has only substance units: false
is: C00318
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
is: HMDB00062
is: CHEBI:16347

metaM asp L m
type: Species
is: SBO:0000247
constant: false
is: HMDB00191
is: CHEBI:29991
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_18300a40_a291_4530_96be_8012874ecc47
name: CYP27A1
is: Q02318
constant: false
is: SBO:0000252
is encoded by: hsa:1593
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaR r0752
kinetic law: MODEL1310110058#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_8bf3d5cd_6e10_4221_8ff3_083585bdf95d
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4882
is: P20594
constant: false
boundary condition: true
type: Species
name: NPR2

metaM e4hglu m
is: HMDB02273
initial amount: NaN
has only substance units: false
is: CHEBI:6331
name: erythro-4-hydroxy-L-glutamate(1-)
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_f4c28659_7db1_4e52_a007_da1c552fc143
name: MGST3
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: O14880
is encoded by: hsa:4259
is: SBO:0000252

metaM cs e deg2 l
has only substance units: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
boundary condition: false
is: CHEBI:57455
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
is: HMDB01354

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaR SADT
is: SBO:0000176
name: sulfate adenylyltransferase
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.1.25
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
product: MODEL1310110058#
reversible: false
fast: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_c38f82a7_a044_48aa_b643_aa0e1019ae98
name: ST3GAL3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6487
constant: false
initial amount: NaN
is: Q96L53
has only substance units: false
type: Species
is: SBO:0000252

metaM nadph c
type: Species
is: CHEBI:57783
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00221
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false

metaM cholcoaone x
is: CHEBI:58507
has only substance units: false
is: HMDB06891
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
boundary condition: false

metaM xylu D c
type: Species
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01644
constant: false
is: CHEBI:17140
has only substance units: false
name: D-xylulose

metaR r1604
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_5a31feaa_e45f_4895_9324_71770dac4d92
constant: false
initial amount: NaN
name: SLC12A6
type: Species
boundary condition: true
is: Q9UHW9
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9990
initial concentration: NaN

metaR NOt
is: SBO:0000185
name: NO transport (diffusion)
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
kinetic law: MODEL1310110058#

metaR P5CDm
reactant: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is described by: ECO:0000269
is: SBO:0000176

metaR CHOLtu
fast: false
name: Choline uniport
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
reactant: MODEL1310110058#
reversible: true
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_f51ae6fa_62df_4b1d_b1e7_376297f867bc
name: BDH1
constant: false
boundary condition: true
is encoded by: hsa:622
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaR DOLPMT1 Ler
is version of: http://identifiers.org/ec-code/2.4.1.258
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110058#
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reactant: MODEL1310110058#

metaM 4abut m
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: C00334
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 4-Aminobutanoate
is: CHEBI:16865
is: HMDB00112
type: Species
boundary condition: false
has only substance units: false

metaR RE3001M
reversible: true
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.1.34
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110058#
name: RE3001
type: Reaction

metaM man g
constant: false
initial concentration: 1.0
is: CHEBI:16024
name: D-mannose
initial amount: NaN
is: HMDB00169
has only substance units: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
boundary condition: false

metaR DDPGAm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is: SBO:0000176
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial

metaR EX c8crn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaR C4DCCACT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_8673e5ac_a78e_4b3e_937a_dda4657b407d
is encoded by: hsa:204
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: AK2
is: P54819

http://identifiers.org/biomodels.db/MODEL1310110058#_2b4ebd55_b46d_4dfd_b685_7984040355a1
constant: false
is encoded by: hsa:80339
initial concentration: NaN
name: PNPLA3
has only substance units: false
boundary condition: true
is: Q9NST1
type: Species
initial amount: NaN
is: SBO:0000252

metaR NACHEX9ly
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false

metaM adp c
is: CHEBI:16761
constant: false
is: http://identifiers.org/pubchem.compound/3310
is: HMDB01341
name: ADP
is: SBO:0000247
boundary condition: false
is: C00008
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM 4abut n
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: 4-Aminobutanoate
is: HMDB00112
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
is: C00334
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_c50ad7e4_d7b9_439a_b20b_cd484c5ed734
has only substance units: false
initial concentration: NaN
name: COX7A2L
type: Species
is encoded by: hsa:9167
initial amount: NaN
constant: false
boundary condition: true
is: Q6FGA0
is: SBO:0000252

metaM 5dhf e
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
name: pentaglutamyl folate (DHF)
is: HMDB06487
constant: false
boundary condition: false

metaR FACOAL150
is: SBO:0000176
name: fatty-acid--CoA ligase
type: Reaction
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: true
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000

metaR FAOXC143C123m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR r0145
fast: false
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.8.3.1
product: MODEL1310110058#
reactant: MODEL1310110058#

metaR GGH 5DHFl
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
type: Reaction
fast: false
product: MODEL1310110058#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_666ccde2_48eb_4d92_9900_93de3008075a
initial concentration: NaN
is: Q9Y2A9
is encoded by: hsa:10331
has only substance units: false
name: B3GNT3
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM lac L e
has only substance units: false
type: Species
name: (S)-lactate
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
is: CHEBI:16651

http://identifiers.org/biomodels.db/MODEL1310110058#_38d28492_f043_4a1d_ad52_b54fab490992
constant: false
is: SBO:0000252
is encoded by: hsa:AL050025
name: _AL050025_1_c
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

metaM man e
initial concentration: 1.0
is: C00159
type: Species
name: D-Mannose
boundary condition: false
initial amount: NaN
is: HMDB00169
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
is: CHEBI:16024
constant: false

metaR ARACHt
kinetic law: MODEL1310110058#
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
reactant: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
fast: false

metaR LPS
is: SBO:0000176
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.1.34
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110058#
is described by: ECO:0000000
name: lipase

http://identifiers.org/biomodels.db/MODEL1310110058#_f72a83d5_68a0_470e_8668_7e80bf45fa02
is: SBO:0000252
initial concentration: NaN
name: _U37519_1_m
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:U37519
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_6a80e349_f5b6_47ea_a14f_c0464e95466c
has only substance units: false
is encoded by: hsa:26227
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: PHGDH
is: O43175

metaM CE5586 c
initial amount: NaN
boundary condition: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
is: CHEBI:58732
constant: false

metaR r1963
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110058#
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR CYOOm3
is version of: http://identifiers.org/ec-code/1.9.3.1
modifier: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
kinetic law: MODEL1310110058#
name: cytochrome c oxidase, mitochondrial Complex IV
reactant: MODEL1310110058#
fast: false

metaR RE1898C
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: true
product: MODEL1310110058#
name: RE1898
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:

metaM coa x
is: HMDB01423
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
name: Coenzyme A
constant: false
initial concentration: 1.0
boundary condition: false

metaR EX glygn2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_98a9f29b_56c6_42f6_b6bc_39add2701264
has only substance units: false
name: BAAT
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q14032
is encoded by: hsa:570

metaM ksii core2 pre1 g
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 1
type: Species
notes: FORMULA: C33H53N3O23X CHARGE: -1
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR GLCURter
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110058#
type: Reaction
fast: false
is: SBO:0000185
name: glucuronate endoplasmic reticular transport
kinetic law: MODEL1310110058#
reversible: false

metaR S6T7g
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110058#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110058#

metaM xylt e
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB02917
name: xylitol
is: CHEBI:17151
has only substance units: false

metaM 2mb2coa c
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 2-methylcrotonoyl-CoA(4-)
has only substance units: false
boundary condition: false
constant: false
is: HMDB02054

http://identifiers.org/biomodels.db/MODEL1310110058#_bcd0e5fa_a0f7_4a57_b80a_b20709c74248
is: SBO:0000252
is encoded by: hsa:26301
constant: false
name: GBGT1
type: Species
is: Q8N5D6
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_92429609_3131_48b8_bab5_1c7761629e42
has only substance units: false
initial concentration: NaN
constant: false
name: PLCG1
is: SBO:0000252
type: Species
is encoded by: hsa:5335
is: P19174
initial amount: NaN
boundary condition: true

metaR r1628
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110058#
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#

metaR C120CPT1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM tetdece1crn e
name: tetradecenoyl carnitine
initial amount: NaN
constant: false
is: HMDB02014
notes: FORMULA: C21H39NO4 CHARGE: 0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_7a622800_f96b_49af_99b7_efe054bd68b0
boundary condition: true
name: PIK3R5:PIK3CG
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000297
constant: false
has part: Q8WYR1
is encoded by: hsa:23533

metaM tcynt m
is: CHEBI:18022
name: thiocyanate
type: Species
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01453
initial amount: NaN

metaR PYRt2r
type: Reaction
reactant: MODEL1310110058#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is: SBO:0000185
modifier: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: pyruvate reversible transport via proton symport
reversible: true

metaR SPMTDe
name: SPMTDe
type: Reaction
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_a57ff607_33ec_4d74_958a_e0f8e7cb9ee8
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:226
name: ALDOA
boundary condition: true
initial amount: NaN
type: Species

metaR r0013
reversible: false
modifier: MODEL1310110058#
fast: false
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110058#

metaR EICOSTETt
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110058#
name: fatty acid transport via diffusion
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110058#

metaR r0149
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_e8247af0_ab25_46a9_b448_e9bc97d964e8
is: P82251
initial amount: NaN
is encoded by: hsa:11136
is: SBO:0000252
constant: false
name: SLC7A9
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR r1629
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
reversible: true
kinetic law: MODEL1310110058#

metaM CE5121 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57449
is: SBO:0000247
name: trans-3-decenoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_221d92a0_503b_497b_9a8f_efbefed0cd0a
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:55753
name: OGDHL
has only substance units: false
initial amount: NaN
constant: false
is: Q9ULD0

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_3b6d920c_cdff_426a_ad46_8155120aba07
type: Species
has only substance units: false
boundary condition: true
is: B7Z3W8
name: SLC6A9
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6536
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_dcaab212_860b_43b2_8898_17dad8c971c1
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: AMY1C
initial amount: NaN
constant: false
is encoded by: hsa:278
is: P04745

metaM q10 m
constant: false
initial amount: NaN
name: ubiquinone-10
is: CHEBI:46245
initial concentration: 1.0
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01072
boundary condition: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_77a7a899_9eae_480a_a1a8_ecaab52b713b
initial amount: NaN
type: Species
constant: false
name: CHPT1
is encoded by: hsa:56994
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q8WUD6

metaM pa hs c
initial concentration: 1.0
type: Species
name: phosphatidate(2-)
is: CHEBI:57739
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

metaM xylt c
type: Species
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02917
has only substance units: false
name: xylitol
is: CHEBI:17151

http://identifiers.org/biomodels.db/MODEL1310110058#_271d98ac_11a1_45dd_9d94_c1544c765271
is encoded by: hsa:5333
has only substance units: false
initial concentration: NaN
is: P51178
type: Species
boundary condition: true
name: PLCD1
initial amount: NaN
constant: false
is: SBO:0000252

metaR r1626
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM tetdece1crn c
has only substance units: false
boundary condition: false
constant: false
is: HMDB02014
initial amount: NaN
name: tetradecenoyl carnitine
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H39NO4 CHARGE: 0

metaM cs b deg3 l
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:21338
type: Species
initial concentration: 1.0
is: HMDB02704
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
notes: FORMULA: C37H55NO38S2 CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110058#_a28e8d27_3691_4d86_ac37_051e331aabcd
constant: false
name: PRDX2
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:7001
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM adrncoa m
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
constant: false
name: adrenyl coenzyme A
is: SBO:0000247
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_d1264f55_e7bf_467a_b457_42d17232f20d
type: Species
is encoded by: hsa:29988
boundary condition: true
is: Q9NY64
name: SLC2A8
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r1400
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110058#
name: Active transport
product: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR LEUKTRF4t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: true
is: SBO:0000185
product: MODEL1310110058#
name: leukotriene F4 transport

metaR GGH 7DHFe
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is: SBO:0000176
kinetic law: MODEL1310110058#
reversible: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#

metaR r1627
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true

metaR G14T5g
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM L2aadp6sa c
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: L-allysine
boundary condition: false
type: Species
is: HMDB01263
is: CHEBI:17917
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076

http://identifiers.org/biomodels.db/MODEL1310110058#_98a35f27_16c5_4244_95ec_cf7755877377
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PCYT1B
type: Species
constant: false
is: E9PD84
is encoded by: hsa:9468
is: SBO:0000252

metaM mi14p c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: HMDB00968
constant: false
initial amount: NaN
is: CHEBI:58282

metaR CHOLtn
name: Choline transport, nuclear through pores
is: SBO:0000185
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
kinetic law: MODEL1310110058#
fast: false
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_6a21cd16_b040_473e_8833_44b1695c0b8f
constant: false
is: O95497
is: SBO:0000252
initial concentration: NaN
name: VNN1
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:8876

http://identifiers.org/biomodels.db/MODEL1310110058#_bf158430_5deb_43eb_9ce8_9bd39be8a3aa
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PDE9A
initial concentration: NaN
is encoded by: hsa:5152
has only substance units: false
constant: false

metaR DM atp c
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
reversible: false
reactant: MODEL1310110058#
is described by: ECO:0000134
kinetic law: MODEL1310110058#
name: DM_atp(c)
type: Reaction
product: MODEL1310110058#
is: SBO:0000176

metaR r1401
is version of: http://identifiers.org/ec-code/3.1.1.3
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.35
is version of: http://identifiers.org/ec-code/2.7.10.1
reversible: false
kinetic law: MODEL1310110058#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.51
reactant: MODEL1310110058#
name: Facilitated diffusion
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_7e8f13f7_dea4_4037_ad93_b4c090c7ddcd
is: SBO:0000252
has only substance units: false
name: HMGCS1
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: Q01581
is encoded by: hsa:3157
initial concentration: NaN

metaR PAIL45P HStn
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
product: MODEL1310110058#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM 3dsphgn c
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
is: HMDB01480
has only substance units: false
constant: false
boundary condition: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
is: CHEBI:58299
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_98b07ace_45b8_45b7_bce6_88774e3d0c9c
boundary condition: true
is: O00483
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: NDUFA4
initial concentration: NaN
constant: false
is encoded by: hsa:4697

metaR RE3568C
is: SBO:0000176
name: RE3568
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b5aa43ca_a30f_440b_9022_411389522a39
has only substance units: false
is encoded by: hsa:29922
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: NME7
initial concentration: NaN
constant: false

metaR ITPtn
kinetic law: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110058#
name: ITP nuclear transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reactant: MODEL1310110058#
reversible: true

metaR r1052
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
kinetic law: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
is: SBO:0000185
name: Vesicular transport
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_226350b4_1d82_4536_b629_365f602a5fb5
has only substance units: false
is: Q9Y2P5
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10998
initial concentration: NaN
name: SLC27A5

metaM amp e
initial amount: NaN
is: HMDB00045
name: AMP
is: C00020
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
has only substance units: false
is: CHEBI:456215

metaR PPAt
product: MODEL1310110058#
name: Propionate transport, diffusion
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110058#
fast: false
reversible: false
is described by: ECO:0000000

metaM adrncoa c
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
name: adrenyl coenzyme A
initial concentration: 1.0
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1

metaR GGH 7DHFl
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR PETOHMm hs
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000254
type: Reaction
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.1.1.17
is: SBO:0000176
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: phosphatidylethanolamine N-methyltransferase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_3cbd359a_e1df_4430_9785_0db8bc6468d5
is: SBO:0000252
initial amount: NaN
name: ALG3
constant: false
has only substance units: false
is encoded by: hsa:10195
initial concentration: NaN
type: Species
is: Q92685
boundary condition: true

metaM prist x
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00795
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
name: pristanic acid
constant: false
is: SBO:0000247
is: CHEBI:51340

metaM HC01223 m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
constant: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
type: Species
has only substance units: false
is: CHEBI:57340
boundary condition: false

metaR NACHEX3ly
is: SBO:0000176
product: MODEL1310110058#
reversible: false
type: Reaction
modifier: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110058#

metaR r2006
is described by: ECO:0000000
modifier: MODEL1310110058#
product: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reactant: MODEL1310110058#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#
type: Reaction

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaR RE3270C
is described by: ECO:0000000
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
type: Reaction
name: RE3270
fast: false
is: SBO:0000176
kinetic law: MODEL1310110058#
reversible: true
product: MODEL1310110058#

metaM hyptaur c
has only substance units: false
boundary condition: false
is: CHEBI:16668
type: Species
name: Hypotaurine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: HMDB00965
constant: false
initial concentration: 1.0

metaR SMPD4
name: sphingomyelinase
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
type: Reaction
is: SBO:0000176
reversible: false

metaM 5dhf m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
has only substance units: false
type: Species
is: HMDB06487
name: pentaglutamyl folate (DHF)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_0b2c656a_efc4_4a06_827a_82b9c6210bb7
is: SBO:0000252
initial amount: NaN
name: NDUFB10
boundary condition: true
has only substance units: false
type: Species
is: A8K761
is encoded by: hsa:4716
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_f0ace469_49d4_48c9_ab9e_cf7dbb165473
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:AI926493
name: _AI926493_1_m

http://identifiers.org/biomodels.db/MODEL1310110058#_76337832_9279_4c97_b90d_1fee1c5ebb0a
is: SBO:0000252
is encoded by: hsa:79611
is: Q9H6R3
type: Species
initial amount: NaN
boundary condition: true
name: ACSS3
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_af809c16_7132_485d_8963_fd033c3206ad
constant: false
is: O95139
name: NDUFB6
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4712
is: SBO:0000252
type: Species

metaR HXPRT
type: Reaction
kinetic law: MODEL1310110058#
is described by: ECO:0000269
fast: false
product: MODEL1310110058#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is: SBO:0000176
reversible: false

metaR C4STMO2r
name: C-4 methyl sterol oxidase
is: SBO:0000176
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.13.72
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_743dc53a_fe7b_4053_bc96_ed886843b7d4
is encoded by: hsa:3099
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P52789
name: HK2

metaM 5dhf l
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
has only substance units: false
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
boundary condition: false
type: Species
is: HMDB06487
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_f3d1f748_fc8b_413d_b920_671238c1a7a1
type: Species
is: Q9Y666
constant: false
name: SLC12A7
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10723
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_1b174138_4d91_4ee8_a2f3_4e96ad7f4ce0
initial concentration: NaN
initial amount: NaN
name: _U52111_1_c
is: SBO:0000252
is encoded by: hsa:U52111
has only substance units: false
type: Species
constant: false
boundary condition: true

metaM man l
is: SBO:0000247
type: Species
is: CHEBI:16024
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: D-mannose
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
constant: false

metaR GPDDA1
reactant: MODEL1310110058#
type: Reaction
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110058#

metaM galgbside hs g
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
is: SBO:0000247
name: galactosylgloboside
constant: false
initial concentration: 1.0
is: CHEBI:18259
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_33a673cd_295b_42f5_96d4_1c63491a1ecb
initial concentration: NaN
is encoded by: hsa:2974
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
name: GUCY1B2
is: SBO:0000252

metaR ACGAGBSIDEtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
name: acgagbside hs intracellular transport
is described by: ECO:0000000
is: SBO:0000185

metaM dolmanp L c
constant: false
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
name: Dolichyl phosphate D-mannose, human liver homolog
is: CHEBI:15809
initial concentration: 1.0

metaM hyptaur e
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16668
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00965
constant: false
name: Hypotaurine

metaR FADtru
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: FAD transporter, endoplasmic reticulum
reversible: false
type: Reaction
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

metaR Htg
fast: false
name: proton diffusion (Golgi)
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_0ec76c00_487d_47a0_9dff_2a92020b11df
is: SBO:0000252
constant: false
name: MAT1A
type: Species
boundary condition: true
is encoded by: hsa:4143
has only substance units: false
initial concentration: NaN
is: Q00266
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_6132c7e4_2c91_4dbd_93e5_18c36409f709
is encoded by: hsa:3098
type: Species
has only substance units: false
name: HK1
is: B3KXY9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0590
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110058#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_6cd6759e_254d_4a9e_a1fe_5ee0abad3e1c
initial amount: NaN
constant: false
is encoded by: hsa:84076
is: SBO:0000252
boundary condition: true
is: Q9H0I9
has only substance units: false
name: TKTL2
type: Species
initial concentration: NaN

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaM tetpent3 e
initial amount: NaN
name: tetracosapentaenoic acid, n-3
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB06323
has only substance units: false
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false

metaM lac L c
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:16651
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: (S)-lactate
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177

metaM CE2838 e
boundary condition: false
name: maltononaose
is: C01936
initial amount: NaN
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_dbec4f92_804a_43fc_8041_2ca668daa664
is: SBO:0000252
has only substance units: false
name: ALG3
type: Species
is encoded by: hsa:10195
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

W3 CDTF: Fri Aug 31 04:30:22 BST 2012

metaR r2002
is described by: ECO:0000000
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
type: Reaction

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaM 4izp c
is: HMDB01014
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57255
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
initial amount: NaN
name: 4-Imidazolone-5-propanoate
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_43c9adae_eb59_4a3a_ba3d_c38cc8502273
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: GLRX2
boundary condition: true
type: Species
is encoded by: hsa:51022

metaM pro D e
type: Species
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
is: CHEBI:16313
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB03411
initial concentration: 1.0
initial amount: NaN

metaM cdp n
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58069
initial concentration: 1.0
is: HMDB01546
type: Species
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110058#_d8d11cb3_df10_4486_8454_650d87ac8684
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23563
initial concentration: NaN
name: CHST5
type: Species
has only substance units: false

metaR BALAPAT1tc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine by PAT1 in renal and intestinal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_27d8752d_2153_48c4_9988_c7ff201e8ab3
type: Species
initial concentration: NaN
has only substance units: false
name: ALG3
constant: false
is encoded by: hsa:10195
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM msa m
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB11111
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: CHEBI:33190
initial amount: NaN
name: 3-oxopropanoate
initial concentration: 1.0
constant: false

metaR SERPT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.50
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
name: serine C-palmitoyltransferase
type: Reaction
modifier: MODEL1310110058#
fast: false
reversible: false

metaM k c
has only substance units: false
boundary condition: false
type: Species
constant: false
is: HMDB00586
is: C00238
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: SBO:0000247
is: CHEBI:29103
initial amount: NaN
initial concentration: 1.0

metaM man r
initial amount: NaN
is: HMDB00169
is: SBO:0000247
name: D-mannose
is: CHEBI:16024
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_0d12c184_db70_4e2a_b713_39a9360787fe
type: Species
name: LDHC
is encoded by: hsa:3948
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P07864
constant: false

metaM amp c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:3322
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: SBO:0000247
boundary condition: false
is: C00020
type: Species
name: AMP
is: HMDB00045

metaR r1050
kinetic law: MODEL1310110058#
reversible: true
name: Vesicular transport
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
product: MODEL1310110058#

W3 CDTF: Fri Aug 31 04:30:22 BST 2012

metaM cdp m
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
has only substance units: false
constant: false
name: CDP(3-)
is: SBO:0000247
is: HMDB01546
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_23d22ed0_50c5_4d29_81eb_5ce9876be8f5
is: SBO:0000252
name: UAP1L1
initial amount: NaN
is encoded by: hsa:91373
boundary condition: true
type: Species
is: Q3KQV9
constant: false
has only substance units: false
initial concentration: NaN

metaR PPAn
reactant: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110058#
name: inorganic diphosphatase, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
fast: false
product: MODEL1310110058#

metaM tetpent3 c
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB06323
is: SBO:0000247
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
name: tetracosapentaenoic acid, n-3

http://identifiers.org/biomodels.db/MODEL1310110058#_ae1521f5_964f_434e_926d_eca2b54b3e92
has part: A8K7W0
has part: O95497
has only substance units: false
is encoded by: hsa:55350
is: SBO:0000297
is encoded by: hsa:8876
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:8875
name: VNN3:VNN2:VNN1
boundary condition: true
constant: false

metaR LNLNCGt
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110058#
name: fatty acid transport via diffusion

metaM lald D c
boundary condition: false
is: SBO:0000247
is: CHEBI:17167
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB06458
type: Species
name: (R)-lactaldehyde

metaM 10fthf m
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00972
is: SBO:0000247
constant: false
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
boundary condition: false
is: CHEBI:57454

metaR r2000
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110058#
is: SBO:0000185
fast: false

metaR r1051
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is described by: ECO:0000000
name: Vesicular transport
reactant: MODEL1310110058#
is: SBO:0000185
reversible: true
fast: false

metaR ALAR
product: MODEL1310110058#
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000212
modifier: MODEL1310110058#
name: alanine racemase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_195975ad_5944_4bcc_9cad_1bff0bf395ed
is encoded by: hsa:257202
initial amount: NaN
initial concentration: NaN
is: P59796
constant: false
name: GPX6
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_a95d8860_487a_4a57_a719_92542bb79dfe
name: ALDH4A1
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: P30038
is encoded by: hsa:8659
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_9cb0df37_0525_49dd_976c_200ce12cdc59
is: SBO:0000252
constant: false
is encoded by: hsa:84701
has only substance units: false
is: Q96KJ9
initial amount: NaN
initial concentration: NaN
name: COX4I2
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_58bde84c_66d7_48ef_939f_a89a1dc3ec45
is: Q6LEN6
initial concentration: NaN
boundary condition: true
type: Species
name: CHAT
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1103

metaR r0591
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
fast: false
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
reactant: MODEL1310110058#
is described by: ECO:0000000
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR 3DSPHR
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
name: 3-Dehydrosphinganine reductase
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.102
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
fast: false

metaM pro D c
type: Species
name: D-proline
is: HMDB03411
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: CHEBI:16313
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_0be9a4a4_74d1_407f_92aa_09c42e2aa9e2
is: SBO:0000252
is encoded by: hsa:6184
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P04843
boundary condition: true
constant: false
name: RPN1

metaR SCP2x
name: peroxisomal thiolase 2
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
modifier: MODEL1310110058#
fast: false

metaR PYRt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
kinetic law: MODEL1310110058#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
name: pyruvate mitochondrial transport via proton symport
product: MODEL1310110058#

metaM k e
constant: false
is: HMDB00586
initial amount: NaN
type: Species
name: potassium
is: C00238
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
has only substance units: false
is: SBO:0000247
is: CHEBI:29103
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_0bd00810_74e8_48d0_9d2e_9199534df326
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: P23109
type: Species
is encoded by: hsa:270
initial concentration: NaN
constant: false
name: AMPD1

metaR NTD10
reversible: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (XMP)
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
type: Reaction
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110058#_2cdbec99_906b_4c0c_bbc7_d4f1f06f4c4e
initial amount: NaN
boundary condition: true
is: Q06136
constant: false
type: Species
is encoded by: hsa:2531
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: KDSR

metaR DURIPP
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
kinetic law: MODEL1310110058#
name: deoxyuridine phosphorylase
fast: false
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000269
product: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110058#

metaM HC01434 m
is: CHEBI:58931
type: Species
constant: false
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR FAOXC4C4DCc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_4021982f_76a7_4c95_b4ad_312b6c688c7a
is encoded by: hsa:6487
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ST3GAL3
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM 10fthf c
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
is: C00234
type: Species
is: HMDB00972
name: 10-Formyltetrahydrofolate
has only substance units: false
boundary condition: false

metaM core2 g
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:15876
name: Core 2
type: Species
has only substance units: false
initial amount: NaN

metaM orn m
constant: false
initial amount: NaN
type: Species
is: C01602
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial concentration: 1.0
is: HMDB00214
boundary condition: false
is: CHEBI:46912
name: Ornithine
has only substance units: false

metaR DNDPt34m
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
modifier: MODEL1310110058#
fast: false
name: dGDP transport via dTDP antiport
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#

metaM dpcoa e
type: Species
name: Dephospho-CoA
constant: false
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: HMDB01373
is: SBO:0000247
is: CHEBI:57328
initial amount: NaN
initial concentration: 1.0
is: C00882
boundary condition: false

metaM oagd3 hs c
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
initial amount: NaN
is: C00329
type: Species
is: CHEBI:17315
constant: false
name: 9-O-Acetylated GD3
is: HMDB01514
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM lac L x
is: HMDB00190
is: CHEBI:16651
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
boundary condition: false
name: (S)-lactate
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR 3MOBte
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Transport of 3-methyl-2-oxobutanoate
fast: false
is described by: ECO:0000134
is: SBO:0000185
reversible: true

metaR r0594
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
is described by: ECO:0000000
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
product: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR ITCOALm
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
type: Reaction
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110058#
is: SBO:0000176
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
reversible: true
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000212

metaM 44mzym r
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01286
type: Species
name: 14-demethyllanosterol
initial amount: NaN
is: CHEBI:18364
initial concentration: 1.0
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108

metaR TMDPK
modifier: MODEL1310110058#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.6.2
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
fast: false
reversible: false
is: SBO:0000176

metaM HC01115 c
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:29025
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
name: NeuNGc

http://identifiers.org/biomodels.db/MODEL1310110058#_ad10479f_7f5c_4b8c_8d38_30d16933a87a
constant: false
is encoded by: hsa:1329
is: Q53YB7
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: COX5B

metaR GLNtm
is: SBO:0000185
kinetic law: MODEL1310110058#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
name: L-glutamine transport via electroneutral transporter
product: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)

metaM cys L c
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17561
has only substance units: false
initial amount: NaN
name: L-cysteine
type: Species
is: HMDB00574
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_5ceb96b4_eb76_4203_b63b_434ae5bc219f
type: Species
constant: false
is encoded by: hsa:8560
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: DEGS1
initial amount: NaN

metaM 3hibutcoa m
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01052
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247
is: CHEBI:28259
initial amount: NaN
constant: false

metaR NAIt
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Na+ / iodide cotransport
modifier: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000269

metaM acgam6p c
initial amount: NaN
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: CHEBI:57513
is: HMDB01062
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaR r0595
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110058#
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
fast: false
product: MODEL1310110058#

metaR EX 6htststerone LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 6 beta hydroxy testosterone exchange
type: Reaction

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR ADPACTD
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaR GLYSNAT5tc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_366fc24d_dc1c_4352_a1a6_16fc185659d6
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q5JPH6
is: SBO:0000252
name: EARS2
boundary condition: true
is encoded by: hsa:124454
initial concentration: NaN

metaM oagd3 hs e
has only substance units: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: CHEBI:18421
constant: false
type: Species
is: SBO:0000247
name: 9-O-Acetylated GD3
boundary condition: false
initial concentration: 1.0
is: HMDB02168
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_5069d758_26a7_4c57_8e16_eb025bf40a86
type: Species
is: Q9ULC5
initial amount: NaN
initial concentration: NaN
name: ACSL5
has only substance units: false
is encoded by: hsa:51703
is: SBO:0000252
boundary condition: true
constant: false

metaR r0596
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
is described by: ECO:0000000
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
fast: false

metaR PNTOte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
reversible: true
name: Transport of (R)-Pantothenate
is described by: ECO:0000134
reactant: MODEL1310110058#

metaM 3hddcoa c
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00623
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_7d7cd734_9c68_4c72_8b00_0f359534d8b2
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM 34dhmald m
is: HMDB06242
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: 3,4-Dihydroxymandelaldehyde
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: C05577
is: SBO:0000247

metaR CYTK12
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
modifier: MODEL1310110058#
reversible: true
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
name: cytidylate kinase (dCMP,dCTP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r0717
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110058#

metaM pglyc hs c
constant: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:60523
initial amount: NaN
name: phosphatidylglycerol(1-)
type: Species

metaM c12dccoa c
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: dodecanedioylcoa
is: HMDB00623
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H51N7O19P3S CHARGE: -5

metaR r0822
is described by: ECO:0000000
modifier: MODEL1310110058#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110058#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
reactant: MODEL1310110058#

metaR CYSTHRNaEx
product: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000269
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
type: Reaction

metaM sarcs m
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: SBO:0000247
type: Species
is: HMDB00271
boundary condition: false
initial concentration: 1.0
constant: false
name: Sarcosine
has only substance units: false
is: C00213
is: CHEBI:15611
initial amount: NaN

metaR 4NPHte
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
name: xenobiotic transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
kinetic law: MODEL1310110058#

metaM amet m
is: C00019
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01185
is: CHEBI:15414
is: SBO:0000247
type: Species
initial amount: NaN
name: S-Adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

metaM HC02216 e
is: CHEBI:28922
name: prostaglandin-f2beta
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR MECOALm
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000212
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110058#
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176

metaR r2373
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_74fca884_46a2_4436_a2ce_f6d46d78b14b
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:53354
boundary condition: true
is: SBO:0000252
name: PANK1

metaR FACOAL260
is: SBO:0000176
name: fatty-acid--CoA ligase (n-C26:0)
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
is described by: ECO:0000000
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR r1527
fast: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.1
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
type: Reaction
kinetic law: MODEL1310110058#
reversible: false
product: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#

metaR CYTK13
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (dCMP,dATP)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#

metaM gam c
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
name: D-Glucosamine
is: HMDB01514
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00329
is: CHEBI:17315
type: Species

metaM 3mop m
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00491
is: SBO:0000247
boundary condition: false
constant: false
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
has only substance units: false

metaR MM8Ber
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.113
fast: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
product: MODEL1310110058#
reversible: false

metaR r2374
reactant: MODEL1310110058#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_6770ccdb_97e1_4dd5_81f0_8f7d33175242
constant: false
initial amount: NaN
name: ACSL1
is encoded by: hsa:2180
type: Species
boundary condition: true
has only substance units: false
is: P33121
is: SBO:0000252
initial concentration: NaN

metaR FATP7t
name: fatty acid electroneutral transport
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.7
reversible: true

metaR MALTSULtm
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Malate:thiosulfate antiport, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_3d6e4b0c_6289_4270_bcb6_0cb7856ca892
initial amount: NaN
has only substance units: false
is: P08237
name: PFKM
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5213

metaM oagd3 hs g
is: C00329
initial concentration: 1.0
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
name: 9-O-Acetylated GD3
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01514
is: CHEBI:17315
is: SBO:0000247

metaM cit m
type: Species
initial concentration: 1.0
is: CHEBI:16947
is: C00158
constant: false
name: Citrate
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
is: HMDB00094

metaR NACDe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR GCC2cm
type: Reaction
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110058#
product: MODEL1310110058#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_9ccf5d94_5c37_4bb7_b516_0b1065b22975
is encoded by: hsa:1738
type: Species
initial amount: NaN
has part: O00330
constant: false
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:1743
has part: Q02218
has part: P09622
is encoded by: hsa:4967
initial concentration: NaN
has only substance units: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:8050
has part: P36957

metaR CYTK14
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,UTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM inost c
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: SBO:0000247
initial concentration: 1.0
name: myo-inositol
is: CHEBI:17268
boundary condition: false
type: Species

metaM pglyc hs e
has only substance units: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:60523
boundary condition: false
is: SBO:0000247
name: phosphatidylglycerol(1-)

http://identifiers.org/biomodels.db/MODEL1310110058#_c8f31eaf_9c9e_471d_815e_59a75ec1bfb3
boundary condition: true
name: ACSL5
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9ULC5
constant: false
is encoded by: hsa:51703
initial amount: NaN

metaR r0715
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/6.3.2.5
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ce1f4897_9a74_46d3_bb9b_0dc64b75302d
is encoded by: hsa:6569
is: Q7Z725
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC34A1
constant: false
has only substance units: false
initial amount: NaN

metaM biliverd c
name: biliverdin(2-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
boundary condition: false
is: HMDB01008
type: Species
initial concentration: 1.0
is: CHEBI:57991

metaR r2371
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110058#
type: Reaction
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_85b9e095_6924_4ec1_b5fc_f51356aa6cae
has only substance units: false
is: Q4F7X0
is encoded by: hsa:114
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: ADCY8
initial amount: NaN

metaR MANt4
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000269
type: Reaction
name: D-mannose transport via sodium cotransport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#

metaM dpcoa c
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
initial amount: NaN
boundary condition: false
is: CHEBI:57328
is: C00882
name: Dephospho-CoA
has only substance units: false

metaR RE1342C
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000000
name: RE1342

metaM cdp e
type: Species
is: CHEBI:58069
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
name: CDP(3-)
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_28f334d2_615c_40d2_959a_31ee90ed67dc
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: P21439
is encoded by: hsa:5244
initial amount: NaN
name: ABCB4
type: Species

metaR r0821
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is: SBO:0000185
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000

metaR r0716
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
kinetic law: MODEL1310110058#
is: SBO:0000176

metaM 10fthf e
initial amount: NaN
constant: false
name: 10-formyltetrahydrofolate(2-)
is: HMDB00972
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110058#_0cf8351a_e4d1_4d3d_bdc8_1a0671ba418b
initial amount: NaN
is: E7EPT3
boundary condition: true
is encoded by: hsa:501
constant: false
has only substance units: false
name: ALDH7A1
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_da3cc411_1b70_4340_8aff_b0aebc99db9f
has only substance units: false
initial amount: NaN
is encoded by: hsa:771
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: CA12

metaR r2372
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110058#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110058#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ef4d4f63_1081_49b8_b8ab_92ad8d108d2e
initial amount: NaN
has only substance units: false
is: P11310
constant: false
is encoded by: hsa:34
initial concentration: NaN
is: SBO:0000252
type: Species
name: ACADM
boundary condition: true

metaM CE2417 m
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: HMDB11123
constant: false
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28387
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_a6e66187_2d08_470f_9c70_9c3c41625934
is: A3KLL5
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: ATP1B1
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:481

http://identifiers.org/biomodels.db/MODEL1310110058#_82958d70_fd41_4af7_b9b9_47d323a0481a
name: MAN2B1
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:4125
boundary condition: true
type: Species
is: O00754

http://identifiers.org/biomodels.db/MODEL1310110058#_25e8960c_7dff_4703_9fc5_b5dd51d361ff
is: SBO:0000252
is: Q12908
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: SLC10A2
is encoded by: hsa:6555

http://identifiers.org/biomodels.db/MODEL1310110058#_69f79dbc_eb07_4220_8c76_167ce311ec97
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q14432
is encoded by: hsa:5139
name: PDE3A
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_34300da7_1c26_4310_93dc_c4ab536e0981
boundary condition: true
is: E9PH29
is encoded by: hsa:10935
name: PRDX3
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

metaM 3ohdcoa m
is: CHEBI:57349
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
boundary condition: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: HMDB06402
constant: false
type: Species
initial amount: NaN

metaR LGTHL
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
name: lactoylglutathione lyase
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/4.4.1.5

metaM doco13ecoa c
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false
name: 13-docosenoylcoa
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR r2377
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110058#
fast: false
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR URATEt
name: urate export from cytosol
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM tdchola c
name: taurochenodeoxycholate
has only substance units: false
is: CHEBI:9407
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
initial concentration: 1.0
is: HMDB00951
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR NDPK8n
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110058#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
product: MODEL1310110058#
is: SBO:0000176
fast: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM lnlnca c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
name: alpha-linolenate
type: Species
boundary condition: false
is: CHEBI:32387
constant: false
initial concentration: 1.0

metaM 10fthf6glu e
initial concentration: 1.0
initial amount: NaN
is: HMDB00972
constant: false
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](6)
is: CHEBI:57454
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110058#_a05580d2_90bc_4657_bf40_fa4bfb2e8ebb
name: PLA2G2D
type: Species
constant: false
is encoded by: hsa:26279
initial amount: NaN
is: Q9UNK4
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR G14T4g
type: Reaction
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110058#
reversible: false
reactant: MODEL1310110058#

metaM inost e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
constant: false
boundary condition: false
is: HMDB00211
is: CHEBI:17268
initial amount: NaN
type: Species
is: SBO:0000247
name: myo-inositol
initial concentration: 1.0
has only substance units: false

metaR r1637
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110058#

metaR RETI2
fast: false
product: MODEL1310110058#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110058#
name: retinol isomerase (9-cis)
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110058#

metaR ADNt
is described by: ECO:0000269
kinetic law: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
reversible: true
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false
name: adenosine facilated transport in cytosol

metaR ASCBOX
fast: false
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: false
name: ascorbic acid oxidase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR GGH 5DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (5DHF), extracellular
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110058#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
is described by: ECO:0000000
modifier: MODEL1310110058#

metaR r2378
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110058#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110058#

metaR r0714
is described by: ECO:0000000
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_b33be80d_e273_4c21_9e19_ddb4bc8f4a34
is encoded by: hsa:10476
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: O75947
is: SBO:0000252
constant: false
name: ATP5H

metaR GDPFUCtg
is: SBO:0000185
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
product: MODEL1310110058#
modifier: MODEL1310110058#
reversible: true
name: GDPFuc Golgi transport via CMP antiport
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
type: Reaction
is described by: ECO:0000269

metaM dpcoa m
is: CHEBI:57328
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 3'-dephospho-CoA(2-)
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
constant: false

metaR 2HBO
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
fast: false
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
reactant: MODEL1310110058#
is described by: ECO:0000269

metaM orn e
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: HMDB00214
is: C01602
initial amount: NaN
name: Ornithine
type: Species
is: CHEBI:0
initial concentration: 1.0

metaM cdp c
is: CHEBI:58069
is: C00112
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01546
constant: false
has only substance units: false
name: CDP
initial concentration: 1.0

metaR r1957
product: MODEL1310110058#
type: Reaction
reversible: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110058#

metaM aicar e
boundary condition: false
type: Species
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475
initial concentration: 1.0
is: HMDB01517
constant: false
is: C04677
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2
has only substance units: false
is: SBO:0000247

metaM sbcoa x
is: SBO:0000247
name: suberylcoa
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C29H43N7O19P3S CHARGE: -5

metaR r1636
modifier: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110058#

metaM 3docopencoa m
name: 3,7,10,13,16-docosapentenoylcoa
constant: false
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790

http://identifiers.org/biomodels.db/MODEL1310110058#_fb912d3a_ffaa_4820_9788_2f96fe14f3e0
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: GAPDHS
is: O14556
initial amount: NaN
has only substance units: false
is encoded by: hsa:26330
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_4d55bd85_102b_4e43_8e16_e8cdc02edd43
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: ACOT2
initial concentration: NaN
boundary condition: true
is: P49753
has only substance units: false
is encoded by: hsa:10965

metaR r2375
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110058#
reversible: true
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110058#

metaM HC02216 c
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:28922
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial concentration: 1.0
has only substance units: false
name: prostaglandin-f2beta
constant: false
type: Species

metaM lnlnca e
initial concentration: 1.0
is: SBO:0000247
is: HMDB01388
has only substance units: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
name: alpha-linolenate
constant: false
is: CHEBI:32387
boundary condition: false
initial amount: NaN

metaM ksi pre25 g
initial concentration: 1.0
is: CHEBI:58053
is: C00130
type: Species
is: HMDB00175
constant: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 25
boundary condition: false
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
initial amount: NaN

metaR r1635
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110058#
product: MODEL1310110058#

metaR CYTK10
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110058#
modifier: MODEL1310110058#
name: cytidylate kinase (CMP,dGTP)
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110058#
fast: false

metaR G14T14g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM ser D c
is: HMDB03406
initial amount: NaN
name: D-serine
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
has only substance units: false

metaR AG13T10g
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
reversible: false
kinetic law: MODEL1310110058#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false

metaR ACACT1r
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110058#
type: Reaction
reversible: true
fast: false
name: acetyl-CoA C-acetyltransferase
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
kinetic law: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_b8a195f9_2eac_412a_b145_a5c9c76d28c6
is: Q0VAA5
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: PLCXD2
initial amount: NaN
is encoded by: hsa:257068
boundary condition: true

metaR r2376
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: true
type: Reaction

metaR CRNrtx
type: Reaction
name: reversible transport of L-Carnitine in peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_927bb1f7_d114_460e_aeee_7d7b5b8f0bdd
name: PIK3CD:PIK3R3
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000297
initial concentration: NaN
has part: A7E2E0
initial amount: NaN
is encoded by: hsa:8503
has part: Q92569
is encoded by: hsa:5293

metaM orn c
constant: false
is: HMDB00214
is: C01602
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: Ornithine
initial concentration: 1.0
is: CHEBI:0
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247

metaR r1634
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM 13dpg c
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: HMDB01270
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3535
type: Species
is: CHEBI:57604
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: C00236
name: 3-Phospho-D-glyceroyl phosphate

metaR CYTK11
modifier: MODEL1310110058#
product: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
name: cytidylate kinase (dCMP,dGTP)
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_95f77810_c3ef_42db_9eff_cd6b67a245f8
is encoded by: hsa:7371
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: Q9BZX2
has only substance units: false
is: SBO:0000252
name: UCK2
constant: false

metaM prist c
is: SBO:0000247
constant: false
is: CHEBI:51340
name: pristanic acid
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00795
initial concentration: 1.0
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)

metaR r1633
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

metaM cys L e
type: Species
initial amount: NaN
boundary condition: false
name: L-cysteine
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
is: CHEBI:17561
constant: false
initial concentration: 1.0
is: HMDB00574
has only substance units: false

metaM ser D e
is: HMDB03406
constant: false
has only substance units: false
type: Species
name: D-serine
is: SBO:0000247
is: CHEBI:16523
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110058#_99f167f2_3a2d_4ac9_b82a_499e47a369cd
is: O00443
is encoded by: hsa:5286
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: PIK3C2A
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_d305cbe1_061a_4021_9c56_24d0a01582d2
initial concentration: NaN
initial amount: NaN
constant: false
name: ALDH6A1
is: SBO:0000252
boundary condition: true
type: Species
is: Q02252
is encoded by: hsa:4329
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_b8653368_720a_4ad3_8139_6d090abbbe98
is encoded by: hsa:5293
name: PIK3CD
is: A7E2E0
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaM mi134p c
is: SBO:0000247
is: HMDB01143
is: CHEBI:58414
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
type: Species
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN

metaM lneldccoa c
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
type: Species
is: http://identifiers.org/pubchem.compound/9543677
boundary condition: false
name: linoelaidyl coenzyme A
initial amount: NaN
is: HMDB06521
constant: false
has only substance units: false
initial concentration: 1.0

metaM sarcs e
boundary condition: false
is: CHEBI:15611
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
name: sarcosine
is: HMDB00271
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM glyclt c
type: Species
has only substance units: false
name: glycolate
is: CHEBI:29805
is: HMDB00115
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: SBO:0000247

metaR VALt5m
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110058#
name: Valine reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110058#

metaM 3hddcoa m
has only substance units: false
is: SBO:0000247
is: C05280
initial amount: NaN
is: HMDB03952
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
type: Species
initial concentration: 1.0
constant: false

metaM cit e
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
initial amount: NaN
type: Species
constant: false
name: citrate(3-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16947

http://identifiers.org/biomodels.db/MODEL1310110058#_0bbc66df_ed89_462c_b4b5_be1d85553c7b
constant: false
is encoded by: hsa:5214
initial amount: NaN
is: Q5VSR7
boundary condition: true
initial concentration: NaN
name: PFKP
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_ea3729cf_0e3f_4685_9567_6d1d92f66b5b
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GCNT4
is: SBO:0000252
type: Species
is: Q9P109
boundary condition: true
is encoded by: hsa:51301

metaR GUACYC
is version of: http://identifiers.org/ec-code/4.6.1.2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: guanylate cyclase
modifier: MODEL1310110058#
is: SBO:0000176
fast: false
reactant: MODEL1310110058#
reversible: false
type: Reaction

metaM thyox L e
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine
is: HMDB00248
initial concentration: 1.0
is: CHEBI:18332
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaR r1632
kinetic law: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#

metaR ACACT1x
is described by: ECO:0000134
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
is: SBO:0000176
product: MODEL1310110058#
type: Reaction

metaR UGT1A10r
is version of: http://identifiers.org/ec-code/2.4.1.17
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: true
fast: false
kinetic law: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000134

metaR r0142
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reversible: false
modifier: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1

http://identifiers.org/biomodels.db/MODEL1310110058#_7450919e_4568_4fea_8cbf_5cda2ba4c6b9
name: PPAP2C
type: Species
is encoded by: hsa:8612
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: E9PAY8
initial amount: NaN
initial concentration: NaN

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaR r0403
is described by: ECO:0000000
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:

metaR PI45PLC
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
kinetic law: MODEL1310110058#
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110058#
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_17fb76c5_05af_48c7_af15_0f669702e58a
initial amount: NaN
constant: false
is encoded by: hsa:224
name: ALDH3A2
has only substance units: false
type: Species
is: P51648
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR HISDC
kinetic law: MODEL1310110058#
is described by: ECO:0000269
modifier: MODEL1310110058#
fast: false
name: histidine decarboxylase
reversible: false
notes: GENE_ASSOCIATION: (1644.1) or (3067.1) SUBSYSTEM: Histidine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:14466899 NOTES:IF
type: Reaction
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.1.1.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
reactant: MODEL1310110058#

metaR TRPO2
notes: GENE_ASSOCIATION: (6999.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES:NCD
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.13.11.11
is described by: ECO:0000269
modifier: MODEL1310110058#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110058#
reversible: false
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
fast: false
product: MODEL1310110058#

metaR r2379
fast: false
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_4411bd2b_fe26_4057_9340_2efe87adf9db
type: Species
is encoded by: hsa:4952
initial amount: NaN
boundary condition: true
name: OCRL
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: Q01968

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR FAOXC2442246x
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR RE0830N
is described by: ECO:0000000
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
type: Reaction
reactant: MODEL1310110058#
reversible: true
product: MODEL1310110058#
is: SBO:0000176
fast: false
name: RE0830
kinetic law: MODEL1310110058#

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_cfddd409_c2ed_4356_9468_1caa0283a0f8
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:10246
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC17A2
is: O00624

metaR r0400
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false

metaR ADPACDAc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_3ceb7c41_1436_4fdd_b02b_06507f190f18
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: _D87002_1_m
initial concentration: NaN
is encoded by: hsa:D87002

http://identifiers.org/biomodels.db/MODEL1310110058#_4342f4ab_5c2f_4b59_b5d4_05476182eaf2
initial amount: NaN
is: Q99884
name: SLC6A7
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6534
type: Species
is: SBO:0000252
constant: false

metaR r1631
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_2890d5d9_a40c_4022_8ab5_705e40bdb8ab
is encoded by: hsa:218
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P30838
name: ALDH3A1
type: Species
constant: false
boundary condition: true

metaR HSD3A2r
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is: SBO:0000176
modifier: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)

metaR CYSSNAT5tc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM sarcs c
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:3513
is: C00213
boundary condition: false
name: Sarcosine
constant: false
is: SBO:0000247
is: HMDB00271

metaR 10FTHFtm
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
type: Reaction
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110058#_abd111f9_2196_4622_879e_8dd2357b31c9
name: SLC32A1
type: Species
constant: false
is encoded by: hsa:140679
initial concentration: NaN
is: SBO:0000252
is: Q9H598
initial amount: NaN
boundary condition: true
has only substance units: false

metaR PPNCL3
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
name: phosphopantothenate-cysteine ligase
is: SBO:0000176
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.5
type: Reaction
modifier: MODEL1310110058#
is described by: ECO:0000269
reversible: false

metaM tetpent6coa x
type: Species
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
is: SBO:0000247
constant: false
name: tetracosapentaenoyl coenzyme A, n-6
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C16172

metaM thyox L c
is: CHEBI:18332
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: HMDB00248
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: L-thyroxine

metaR RE1520M
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110058#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1520
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110058#_77e15c9c_e5b9_4128_be9d_9d24269c225a
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: SLC26A1
initial amount: NaN
is encoded by: hsa:10861

http://identifiers.org/biomodels.db/MODEL1310110058#_dd631bcf_f4bc_4d7e_a946_9b05718dbfbd
is encoded by: hsa:N63787
has only substance units: false
constant: false
name: _N63787_1_c
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR r1630
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110058#
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_d1833d46_57ed_4a26_a857_52920ff71f4d
is encoded by: hsa:3633
initial amount: NaN
initial concentration: NaN
name: INPP5B
has only substance units: false
is: P32019
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_65fc82db_87d0_453f_b7c6_e086d58afd9c
type: Species
name: SLCO1B1
boundary condition: true
constant: false
is encoded by: hsa:10599
has only substance units: false
is: Q9Y6L6
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r0829
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.1.1.37
is: SBO:0000185
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_a8e7952b_4c4d_4ef5_9bbe_7a22aa7c78bc
initial amount: NaN
is encoded by: hsa:5211
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: P17858
name: PFKL

metaM aicar c
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:58475
constant: false
boundary condition: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
is: HMDB01517
is: C04677
initial amount: NaN

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR DPCOAPPe
kinetic law: MODEL1310110058#
name: Pyrophasphatase (dephospho-CoA, extracellular)
is: SBO:0000176
fast: false
reactant: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
product: MODEL1310110058#

metaM h2o2 x
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Hydrogen peroxide
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00027
constant: false
is: CHEBI:16240
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaM Asn X Ser Thr r
is: SBO:0000247
boundary condition: false
is: HMDB00051
constant: false
has only substance units: false
is: CHEBI:28938
name: protein-linked asparagine residue (N-glycosylation site)
type: Species
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: C01342
initial concentration: 1.0

metaR UDPGALtg
name: UDP-Gal Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110058#
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_feef9421_f069_42a2_995c_f9bd53dfd90f
type: Species
constant: false
is encoded by: hsa:4668
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P17050
name: NAGA
boundary condition: true

metaR FACOAL140i
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
type: Reaction
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110058#
name: fatty-acid--CoA ligase (tetradecanoate)
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR

metaR ECOAH9m
is: SBO:0000176
modifier: MODEL1310110058#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110058#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110058#
is described by: ECO:0000304

metaR HGNTOR
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.13.11.5
reactant: MODEL1310110058#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_4a1a839d_71fd_402c_a644_c712a7374f7e
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5152
type: Species
initial amount: NaN
name: PDE9A
constant: false

metaM dolp L c
type: Species
is: CHEBI:57683
name: dolichyl phosphate(2-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

metaM thf c
initial amount: NaN
type: Species
is: CHEBI:57453
boundary condition: false
name: 5,6,7,8-Tetrahydrofolate
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0
is: SBO:0000247
is: C00101
has only substance units: false
is: HMDB01846

http://identifiers.org/biomodels.db/MODEL1310110058#_895e6b89_4065_4462_ad83_f40b9f718194
is: P23921
has only substance units: false
is encoded by: hsa:6240
initial amount: NaN
boundary condition: true
name: RRM1
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5e8a4784_b457_413b_8c10_1682abdfc9d3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: COX2
type: Species
is: Q7GXZ8
constant: false
has only substance units: false
is encoded by: hsa:4513
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_c5bc92b4_2d98_4778_98de_bcf82947a459
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q6PXP3
is encoded by: hsa:155184
name: SLC2A7

metaM hdcoa c
boundary condition: false
type: Species
has only substance units: false
is: HMDB06532
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
initial concentration: 1.0
name: Hexadecenoyl-CoA (n-C16:1CoA)

metaR UDPGLCAter
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110058#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reversible: true
type: Reaction

metaM occoa c
has only substance units: false
name: Octanoyl-CoA (n-C8:0CoA)
is: HMDB01070
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
is: C01944
initial concentration: 1.0
boundary condition: false

metaM gthox c
type: Species
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247
is: HMDB03337
has only substance units: false
is: CHEBI:58297
name: Oxidized glutathione
boundary condition: false
initial concentration: 1.0
constant: false
is: C00127
initial amount: NaN

metaR EX c5dc
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaM sphs1p e
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00277
is: SBO:0000247
type: Species
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
name: sphingosine 1-phosphate(1-)

W3 CDTF: Fri Aug 31 04:30:23 BST 2012

metaR LGNCt
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110058#
type: Reaction
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR S4TASE5ly
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
fast: false
modifier: MODEL1310110058#
reversible: true
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is described by: ECO:0000000

metaR PMTCOAtx
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000000
name: fatty acid intracellular transport
reactant: MODEL1310110058#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185

metaR r0730
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
fast: false
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_d468aa6a_ccba_4674_80f7_fe833603f6c2
initial concentration: NaN
is encoded by: hsa:8399
initial amount: NaN
constant: false
is: O15496
has only substance units: false
type: Species
is: SBO:0000252
name: PLA2G10
boundary condition: true

metaM 3pg c
boundary condition: false
has only substance units: false
is: HMDB00807
is: CHEBI:58272
is: SBO:0000247
is: C00197
name: 3-Phospho-D-glycerate
is: http://identifiers.org/pubchem.compound/3497
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

metaM c12dc c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C19H34NO6 CHARGE: -1
type: Species
constant: false
name: dodecanedioyl carnitine
is: SBO:0000247
has only substance units: false
is: HMDB00623

metaR VALTA
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
modifier: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
name: valine transaminase
fast: false
is described by: ECO:0000269

metaR DDECCRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaR RDH1a
name: retinol dehydrogenase (all-trans,NADPH)
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.105
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
product: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.300
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_e9e61017_38eb_4d61_ab2e_12b72687528d
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O00462
constant: false
boundary condition: true
name: MANBA
is encoded by: hsa:4126

metaR CSPG Btly
is: SBO:0000185
reversible: false
product: MODEL1310110058#
type: Reaction
fast: false
name: chondroitin sulfate B transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR S6T6g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
type: Reaction
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is described by: ECO:0000000
product: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#

metaR r0157
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.2
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false

metaR TETPENT6t
kinetic law: MODEL1310110058#
name: fatty acid transport via diffusion
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
fast: false
reversible: true

metaM sphs1p c
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
type: Species
initial amount: NaN
is: HMDB00277
name: sphingosine 1-phosphate(1-)
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR NADtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110058#
name: transport of NAD into peroxisome
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

metaM strch1 e
constant: false
notes: FORMULA: C66H112O56 CHARGE: 0
is: SBO:0000247
is: CHEBI:456215
type: Species
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})
initial amount: NaN
is: HMDB00045
is: C00020
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM gln L e
type: Species
is: HMDB00641
constant: false
is: CHEBI:18050
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
boundary condition: false
name: L-glutamine
initial amount: NaN

metaR MANtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110058#
name: mannose efflux from Golgi apparatus
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#
is: SBO:0000185

metaR FACOAL161
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (hexadecenoate)
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000000

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR r1638
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_84bdaa12_baf3_455f_9c3a_1b7d7b61e617
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: CMAS
constant: false
is: Q8NFW8
is: SBO:0000252
is encoded by: hsa:55907

http://identifiers.org/biomodels.db/MODEL1310110058#_8e60aa8b_9606_483d_a23b_1f75af91023e
constant: false
is: P42126
is encoded by: hsa:1632
initial concentration: NaN
name: ECI1
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaR r0027
is version of: http://identifiers.org/ec-code/1.14.13.39
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is: SBO:0000176

metaR CSBPASEly
reversible: false
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_06a7973f_f241_4775_818a_56195a95f8e6
is: P27708
constant: false
name: CAD
is encoded by: hsa:790
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaR GTHP
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.9
modifier: MODEL1310110058#
name: glutathione peroxidase
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.15

http://identifiers.org/biomodels.db/MODEL1310110058#_00cc8f8a_cf60_49f4_9879_a6cc630cebad
is: SBO:0000252
is: O95477
is encoded by: hsa:19
initial amount: NaN
type: Species
constant: false
name: ABCA1
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_370f7ae8_a4a1_419d_8d87_83fb210abace
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
name: _X63359_1_c
is encoded by: hsa:X63359
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR GASNASE2ly
fast: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
reversible: false
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.26
is described by: ECO:0000000
name: glycosylasparaginase, lysosomal

metaR r1639
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110058#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_da6939c9_45d2_490e_8233_acb90cdb4968
name: ADH1C
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: P00326
has only substance units: false
is: SBO:0000252
is encoded by: hsa:126

metaR UDPACGALtl
kinetic law: MODEL1310110058#
reversible: true
name: udpacgal intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
product: MODEL1310110058#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110058#

metaR LEUKTRE4t
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110058#
name: leukotriene E4 transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ab25e991_cce7_4501_bf5c_3f7b96c9c281
type: Species
boundary condition: true
initial amount: NaN
is: P00533
is encoded by: hsa:1956
is: SBO:0000252
name: EGFR
initial concentration: NaN
has only substance units: false
constant: false

metaM gln L c
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
type: Species
initial concentration: 1.0
is: HMDB00641
constant: false
is: CHEBI:18050
name: L-glutamine
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_bba6fc82_be12_44fa_9a62_fb68ea61975b
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI971036
constant: false
type: Species
initial amount: NaN
name: _AI971036_1_c
boundary condition: true
initial concentration: NaN

metaR C4STMO1r
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
is: SBO:0000176
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
reversible: false
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.13.72
fast: false
modifier: MODEL1310110058#
type: Reaction

metaR GTHO
is version of: http://identifiers.org/ec-code/1.8.1.7
is described by: ECO:0000254
type: Reaction
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
fast: false
reactant: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
name: glutathione oxidoreductase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_b7016ad6_f6c3_42ad_aca0_edf70118f7d1
boundary condition: true
name: PIK3R1
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: B3KT19
type: Species
is encoded by: hsa:5295
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_3a45cda6_10f1_405e_994e_e37cbe1e176b
constant: false
is encoded by: hsa:2348
is: SBO:0000252
name: FOLR1
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_6ed526d4_97c3_434b_8f66_4f07d563a1ed
is: SBO:0000252
name: PDE3B
is: A7E2E5
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:5140

metaM l2fn2m2masn g
boundary condition: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
constant: false
initial concentration: 1.0
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial amount: NaN
type: Species

metaR G14T6g
fast: false
reactant: MODEL1310110058#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110058#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110058#_5326bfd1_9025_4926_a988_09d11ace18d0
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:1719
is: P00374
constant: false
is: SBO:0000252
name: DHFR
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_98717814_f580_4f3b_9792_574b2831bd76
initial amount: NaN
is encoded by: hsa:1376
has only substance units: false
is: SBO:0000252
type: Species
name: CPT2
boundary condition: true
initial concentration: NaN
is: P23786
constant: false

metaR GLYPHEHYc
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
product: MODEL1310110058#
type: Reaction
fast: false
name: hydrolysis of glycylphenylalanine
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110058#_46dd09ab_656a_4a59_9507_4b7fe30090d9
name: AOC2
has only substance units: false
is: O75106
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:314
constant: false
initial amount: NaN
initial concentration: NaN

metaM 3mob m
is: HMDB00019
constant: false
initial amount: NaN
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:11851
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

http://identifiers.org/biomodels.db/MODEL1310110058#_991ebc8e_6679_46ff_b844_dd2c5e2f09a8
is: Q5T4W8
type: Species
name: ST3GAL3
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6487
initial amount: NaN
constant: false

metaR RE0830C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
name: RE0830

http://identifiers.org/biomodels.db/MODEL1310110058#_b37fa082_2762_4189_8113_ec0d9f459ccc
boundary condition: true
initial amount: NaN
constant: false
name: GPX7
is encoded by: hsa:2882
is: Q96SL4
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_1ce1e160_b8e0_4ce7_a3e3_6c1358221168
is: SBO:0000252
is: P38571
boundary condition: true
constant: false
is encoded by: hsa:3988
name: LIPA
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_0ec0192b_0122_4ca0_a2dc_8139bf126f1d
initial concentration: NaN
is: O00217
initial amount: NaN
has only substance units: false
name: NDUFS8
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:4728
type: Species

metaM ala L e
is: SBO:0000247
initial amount: NaN
name: L-alanine
constant: false
is: HMDB00161
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: CHEBI:16977
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_aebe4c9e_d585_4095_9f5c_b26d4d8f1b32
has only substance units: false
name: NME1
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4830
constant: false
initial concentration: NaN

metaR FAOXC12C10x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

metaR UGCG
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.80
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
kinetic law: MODEL1310110058#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
reactant: MODEL1310110058#
name: Ceramide glucosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110058#_6df72669_6d43_4f28_a2b9_05abb65b7ccd
is: SBO:0000252
is encoded by: hsa:4711
initial concentration: NaN
type: Species
name: NDUFB5
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: O43674

http://identifiers.org/biomodels.db/MODEL1310110058#_3d2d3a93_b32f_40f4_b383_afb80817e76b
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:57786
is: Q9NYW8
constant: false
is: SBO:0000252
name: RBAK
initial amount: NaN

metaR INSTt4 2
type: Reaction
kinetic law: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
reactant: MODEL1310110058#
is described by: ECO:0000006
modifier: MODEL1310110058#
name: inositol transport via sodium symport
reversible: true
product: MODEL1310110058#
is: SBO:0000185

metaM ksi pre30 g
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
type: Species
is: C00130
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 30
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM amet c
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01185
is: CHEBI:15414
name: S-Adenosyl-L-methionine
constant: false
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
boundary condition: false
has only substance units: false
initial amount: NaN

metaR FAS120COA
reactant: MODEL1310110058#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
fast: false
is: SBO:0000176
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C12:0CoA)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_d1c71ecd_474d_4ee9_8d06_35ae505eee3a
constant: false
type: Species
is: SBO:0000252
name: ST3GAL3
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6487

metaM glyclt x
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00115
is: CHEBI:29805
name: glycolate
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_13fba8bd_a424_4f60_a467_37b2f1544e18
has only substance units: false
is encoded by: hsa:54
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: ACP5
is: P13686

metaR r2140
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110058#
reversible: true
product: MODEL1310110058#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110058#_7b61ecf7_299c_4fa5_93f1_1c678033308e
is encoded by: hsa:10588
type: Species
initial concentration: NaN
is: P49914
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: MTHFS

metaM chsterol c
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:16113
initial amount: NaN
initial concentration: 1.0
is: HMDB00067
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol
has only substance units: false

metaR RE0583C
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: true
name: RE0583
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
type: Reaction

metaR MACACI
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.18
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
kinetic law: MODEL1310110058#
is described by: ECO:0000269
name: maleylacetoacetate isomerase
product: MODEL1310110058#

metaR NACHEX8ly
product: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_38aa4b53_1b22_43c2_9029_b44b7f209e9d
is encoded by: hsa:374907
name: B3GNT8
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR FAOXC103C102m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaM nad c
constant: false
type: Species
initial concentration: 1.0
is: C00003
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
is: HMDB00902
has only substance units: false

metaR FE3MTP1
product: MODEL1310110058#
is described by: ECO:0000134
fast: false
type: Reaction
reactant: MODEL1310110058#
name: transport of ferrous iron into blood
kinetic law: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:

metaM m5mpdol L r
is: CHEBI:37634
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5e4dfc5a_3c8b_4cf5_af94_7e1b919f3c55
initial amount: NaN
type: Species
is encoded by: hsa:AI469183
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: _AI469183_1_x
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_8d8b1038_a6c3_49ba_a505_3fc75f7bcbcb
is encoded by: hsa:518
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
has part: P48201
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
constant: false

metaR PRO1x
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is version of: http://identifiers.org/ec-code/1.5.99.8
is described by: ECO:0000134
fast: false
reversible: false
product: MODEL1310110058#
is: SBO:0000176
name: L-ProlineNAD+ 5-oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110058#_894cebeb_0281_4a5d_99f1_0ad6be35542a
constant: false
type: Species
is encoded by: hsa:100128062
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _100128062_1_m

metaR VLCS2p
kinetic law: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
name: Very-long-chain-fatty-acid-CoA ligase
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_dce3f392_e501_476e_ab2b_bc2c9bff19f9
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: Q6FGV9
is encoded by: hsa:10654
is: SBO:0000252
type: Species
name: PMVK
initial concentration: NaN

metaR PCHOLP hs
is described by: ECO:0000269
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
name: choline phosphatase
reversible: false
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4

metaR r2142
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110058#

metaR r0580
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is described by: ECO:0000000
modifier: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.7
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_3670ec74_3d1e_405e_b61b_f5f5306ca1b8
initial amount: NaN
is: Q9BZV2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: SLC19A3
type: Species
is encoded by: hsa:80704

http://identifiers.org/biomodels.db/MODEL1310110058#_b785c734_8d57_4467_aa12_49751db7f265
type: Species
boundary condition: true
name: SLC16A3
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O15427
is encoded by: hsa:9123

metaM gchola c
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58235
is: HMDB00138
initial concentration: 1.0
constant: false
boundary condition: false
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
has only substance units: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR CH25H
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110058#
is described by: ECO:0000269
reversible: false
type: Reaction
name: cholesterol 25-hydroxylase
fast: false
product: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.99.38

metaM 3mob c
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00019
boundary condition: false
type: Species
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_5836a33b_ecb4_4c18_8f09_622b89bc5688
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:109
is: SBO:0000252
is: B3KT86
name: ADCY3
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_2ffac91d_bfba_47d2_be16_e235705d9790
name: HK3
initial concentration: NaN
initial amount: NaN
is: P52790
constant: false
boundary condition: true
type: Species
is encoded by: hsa:3101
is: SBO:0000252
has only substance units: false

metaM chsterol e
name: cholesterol
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00067
boundary condition: false
is: CHEBI:16113
constant: false

metaR r0268
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
modifier: MODEL1310110058#
reversible: true
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2

metaR r2141
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110058#
type: Reaction
is: SBO:0000185

metaM cs b deg1 l
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01354
is: CHEBI:57455
constant: false
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
notes: FORMULA: C45H67N2O46S3 CHARGE: -5

metaR MM6B2g
kinetic law: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaR GALU
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
fast: false
kinetic law: MODEL1310110058#
reversible: true
reactant: MODEL1310110058#
product: MODEL1310110058#
modifier: MODEL1310110058#
name: UTP-glucose-1-phosphate uridylyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.9
is: SBO:0000176

metaR VLCS2r
fast: false
is: SBO:0000176
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
modifier: MODEL1310110058#

metaM CE2839 e
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
is: SBO:0000247
is: C01936
name: maltodecaose
boundary condition: false
initial concentration: 1.0

metaM coa c
type: Species
boundary condition: false
name: Coenzyme A
constant: false
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
initial amount: NaN
is: C00010
has only substance units: false
is: SBO:0000247
is: CHEBI:3312
initial concentration: 1.0

metaM phaccoa c
is: CHEBI:57390
constant: false
is: HMDB06503
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
name: phenylacetyl-CoA(4-)

metaM gchola e
constant: false
boundary condition: false
is: SBO:0000247
name: glycocholate
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0
is: HMDB00138

metaR r0267
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
product: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.5.1.9
fast: false

metaR L LACt2r
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
reversible: true
name: L-lactate reversible transport via proton symport
is: SBO:0000185
product: MODEL1310110058#

metaM HC01501 c
initial concentration: 1.0
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:33539
has only substance units: false
type: Species
constant: false
name: hydroxidodioxidosulfidosulfate(1-)

metaM ditp c
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: HMDB03537
has only substance units: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
initial amount: NaN
is: CHEBI:61382

metaR GALT
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
name: galactose-1-phosphate uridylyltransferase
reversible: true
modifier: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.12

metaR CYSGLTH
name: Glutathione:cystine oxidoreductase
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM imp c
is: C00130
is: HMDB00175
is: CHEBI:58053
has only substance units: false
boundary condition: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
name: IMP
type: Species

metaM 3mob e
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate

metaM Asn X Ser Thr l
is: CHEBI:28938
notes: FORMULA: XH CHARGE: 0
name: protein-linked asparagine residue (N-glycosylation site)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00051
is: C01342
type: Species

metaR FAOXC142C122m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaR RE1810M
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
is: SBO:0000176
fast: false
name: RE1810
is described by: ECO:0000000
type: Reaction

metaM ala L m
is: HMDB00161
is: SBO:0000247
is: CHEBI:16977
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: L-alanine
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5ff470c2_1601_4094_af1d_2b9a0c39f3e0
is: SBO:0000252
constant: false
name: NDUFV3
type: Species
initial concentration: NaN
is encoded by: hsa:4731
has only substance units: false
boundary condition: true
is: P56181
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_fec31f3b_3cb6_43a1_83f7_a9ee1a6e13be
is encoded by: hsa:AI631997
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: _AI631997_1_m
initial concentration: NaN

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR C3DCe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR DLNLCGt
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110058#
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_08883665_7768_4c81_9947_9338fd42a3d1
has only substance units: false
is encoded by: hsa:4830
boundary condition: true
name: NME1:NME2
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000297
type: Species

metaM xoldiolone c
is: HMDB02197
has only substance units: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
boundary condition: false
is: CHEBI:28477
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN

metaM din c
constant: false
name: Deoxyinosine
is: CHEBI:28997
initial concentration: 1.0
boundary condition: false
is: C05512
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: HMDB00071
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_f458d47c_8f7e_474d_a081_1136ff7d51b7
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:205
has only substance units: false
boundary condition: true
constant: false
is: P27144
is: SBO:0000252
name: AK4

metaR EX pectintchol LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-taurocholic acid complex
type: Reaction

metaR G6Pter
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
type: Reaction
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
reversible: true
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110058#

metaR FAOXC102m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaR r0999
is: SBO:0000185
name: Facilitated diffusion
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_00759815_67f2_412a_ad9d_3f4895330d71
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM coa g
name: coenzyme A(4-)
boundary condition: false
is: HMDB01423
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR PCm
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
modifier: MODEL1310110058#
name: pyruvate carboxylase
product: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.4.1.1
reversible: false
is described by: ECO:0000269

metaM pa hs m
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:57739
initial concentration: 1.0

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM pheme e
is: C00032
initial concentration: 1.0
constant: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17627
is: HMDB03178
name: Protoheme
type: Species
has only substance units: false

metaR CSPG Etly
product: MODEL1310110058#
is described by: ECO:0000000
name: chondroitin sulfate E transport, extracellular to lysosome
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_9db2d89b_40cf_4ef0_a8d0_c5dbe5e517c3
is: SBO:0000252
is encoded by: hsa:8875
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: O95498
name: VNN2
initial concentration: NaN
constant: false

metaM bilglcur e
is: CHEBI:57767
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

http://identifiers.org/biomodels.db/MODEL1310110058#_e3be85a1_1192_43e1_b1f5_4d68b698ad70
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:514
initial concentration: NaN
boundary condition: true
name: ATP5E
is: SBO:0000252

metaR ASPDTDe
is: SBO:0000185
product: MODEL1310110058#
is described by: ECO:0000134
fast: false
reversible: true
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
type: Reaction
kinetic law: MODEL1310110058#
name: D-aspartate transport, extracellular

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR NICRNS
type: Reaction
is described by: ECO:0000000
name: NICRNS
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
is: SBO:0000176
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_1ed5d8c7_ac92_4783_887a_523c1bba50e7
has only substance units: false
constant: false
type: Species
name: ALDH3A1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P30838
is encoded by: hsa:218

http://identifiers.org/biomodels.db/MODEL1310110058#_40624ce6_5a03_434a_b2d0_dfcd3bef065b
name: _AD000092_1_c
initial concentration: NaN
is encoded by: hsa:AD000092
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR r0584
reversible: true
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000000
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR MDHm
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.37
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reversible: true
name: malate dehydrogenase, mitochondrial
product: MODEL1310110058#
is described by: ECO:0000134
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_79146b50_c26d_4f8c_a5a5_3a0333afbfe2
name: PECR
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55825
boundary condition: true
initial amount: NaN
type: Species
is: Q9BY49
constant: false
is: SBO:0000252

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM coa e
has only substance units: false
initial concentration: 1.0
is: CHEBI:57287
type: Species
is: SBO:0000247
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
is: HMDB01423
boundary condition: false
initial amount: NaN
name: Coenzyme A

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_f42dec2e_f157_43c2_96c4_c07622a87075
boundary condition: true
type: Species
name: SLC13A4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:26266
constant: false
is: Q9UKG4
has only substance units: false
initial concentration: NaN

metaM dcholcoa x
is: CHEBI:28701
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_9b6bb939_ab8d_4f14_8e3b_679dc07d8f0a
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:223
boundary condition: true
initial concentration: NaN
name: ALDH9A1
is: P49189
type: Species

metaR r0830
product: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_04f447fd_88f6_4609_a1b7_229aeef5c983
is: SBO:0000252
initial amount: NaN
name: GLUD1
is: E9KL48
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:2746
boundary condition: true

metaR FRDPtcr
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false
type: Reaction
product: MODEL1310110058#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
reversible: true
is described by: ECO:0000134

metaM gal1p c
constant: false
has only substance units: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
initial amount: NaN
boundary condition: false
is: CHEBI:58336
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00645

metaR r1641
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM udp g
initial concentration: 1.0
is: CHEBI:58223
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
boundary condition: false
name: UDP(3-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_86561901_aa0c_41a8_851b_e1e6327594fb
is: Q16706
constant: false
is: SBO:0000252
name: MAN2A1
type: Species
has only substance units: false
is encoded by: hsa:4124
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM glutcoa m
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57378
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01339
name: glutaryl-CoA(5-)

metaM pheme c
initial concentration: 1.0
is: C00032
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
boundary condition: false
constant: false
is: CHEBI:17627
is: SBO:0000247
initial amount: NaN
name: Protoheme
is: HMDB03178
has only substance units: false
type: Species

metaM bilglcur c
has only substance units: false
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR PROt4 2 r
is described by: ECO:0000006
kinetic law: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
reversible: true
name: Proline transport (sodium symport) (2:1)
product: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
is: SBO:0000185

metaM chsterol l
name: cholesterol
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16113
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_585fbe57_e842_48ac_bc85_fb7f3a22f1e1
is: Q9NTN3
is: SBO:0000252
name: SLC35D1
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:23169
has only substance units: false

metaM HC00361 c
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
name: sedoheptulose 1,7-bisphosphate(4-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:58335
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_91583fcf_17dc_4467_827d_935cf137de87
type: Species
is encoded by: hsa:8050
initial concentration: NaN
initial amount: NaN
name: PDHX
boundary condition: true
is: SBO:0000252
is: O00330
has only substance units: false
constant: false

metaR BDHm
fast: false
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.30
type: Reaction

metaM dolp L r
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
constant: false
boundary condition: false
is: CHEBI:57683
type: Species
name: dolichyl phosphate(2-)
has only substance units: false
initial amount: NaN

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_0f09d15f_3eab_4573_a966_b35f219c3d1a
type: Species
constant: false
name: ACSL3
is: SBO:0000252
is: O95573
initial concentration: NaN
is encoded by: hsa:2181
boundary condition: true
initial amount: NaN
has only substance units: false

metaR DDCRNe
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaR r1640
is: SBO:0000185
product: MODEL1310110058#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#

metaR r0998
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
is: SBO:0000185

metaM strch2 e
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:4167
notes: FORMULA: C18H32O16 CHARGE: 0
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
is: HMDB00122
initial concentration: 1.0
constant: false

metaM amp m
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
initial concentration: 1.0
constant: false
name: AMP(2-)
type: Species
is: HMDB00045

metaR r1538
reactant: MODEL1310110058#
modifier: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
type: Reaction

metaR NH4t3r
name: ammonia transport via proton antiport
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#

metaM alpro m
is: SBO:0000247
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
type: Species
boundary condition: false
initial concentration: 1.0
name: S-Aminomethyldihydrolipoylprotein
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:16882

http://identifiers.org/biomodels.db/MODEL1310110058#_6bb23e5c_a8b2_48c6_8771_d7e5d80c45e6
name: B3GNT2
is: SBO:0000252
is encoded by: hsa:10678
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_01ed8bbf_725d_43de_bc38_809f763a93a3
constant: false
initial amount: NaN
is: P78330
initial concentration: NaN
is encoded by: hsa:5723
is: SBO:0000252
boundary condition: true
type: Species
name: PSPH
has only substance units: false

metaM udp e
name: UDP(3-)
constant: false
initial amount: NaN
is: CHEBI:58223
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
has only substance units: false
is: HMDB00295
initial concentration: 1.0
boundary condition: false

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR DESAT16 2
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.19.1
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ

metaR GMAND
product: MODEL1310110058#
name: GDP-D-mannose dehydratase
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.47
reversible: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
type: Reaction

metaM gm3 hs g
boundary condition: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:60065
initial amount: NaN
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
initial concentration: 1.0
type: Species

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR r0587
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110058#
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is: SBO:0000176
reversible: true

metaM chsterol m
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00067
initial amount: NaN
name: cholesterol
is: SBO:0000247
is: CHEBI:16113
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false

metaR r0728
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: true
product: MODEL1310110058#
fast: false
type: Reaction
kinetic law: MODEL1310110058#

metaR ACGAGBSIDEtl
type: Reaction
product: MODEL1310110058#
name: acgagbside hs intracellular transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110058#

metaR ARACHDt2
type: Reaction
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
reactant: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
name: fatty acid transport via diffusion

metaM h2o2 c
is: HMDB03125
boundary condition: false
is: CHEBI:16240
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00027
constant: false
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false

metaM CE2432 m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
has only substance units: false
type: Species
is: CHEBI:57795
constant: false
boundary condition: false
is: SBO:0000247

metaR r2360
reactant: MODEL1310110058#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110058#
is: SBO:0000185

metaR SPHMDAc
type: Reaction
name: sphingomyelin deacylase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110058#
reversible: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12069827 NOTES:limited details on mechanism, localization, etc. See PMID: 12069827 NJ
reactant: MODEL1310110058#
is described by: ECO:0000000

metaR KCCt
modifier: MODEL1310110058#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110058#
is: SBO:0000185
reversible: true
type: Reaction
name: K+-Cl- cotransport
fast: false
reactant: MODEL1310110058#
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_13c07735_0b62_427b_b7cb_006314c5ed5a
is encoded by: hsa:8883
is: A8MU28
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: NAE1
initial amount: NaN

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_0fb70f50_1ec5_4734_a049_061b74079cbe
name: SLC23A2
is encoded by: hsa:9962
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR FAEL205
reactant: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
type: Reaction
modifier: MODEL1310110058#
reversible: false
product: MODEL1310110058#
fast: false
name: fatty-acyl-CoA elongation (n-C20:5CoA)
is: SBO:0000176

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_5bd0b983_d859_46b1_94d4_949744788575
constant: false
boundary condition: true
type: Species
is encoded by: hsa:5296
is: SBO:0000252
initial amount: NaN
name: PIK3R2
has only substance units: false
is: O00459
initial concentration: NaN

metaR FATP8t
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
name: fatty acid electroneutral transport
type: Reaction

metaM 3pg m
has only substance units: false
is: SBO:0000247
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: CHEBI:58272
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: HMDB00807
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_a0bcf17c_6465_4dfa_8d47_bac1096ed1ce
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:9856
is: SBO:0000252
is: F5H123
name: DYLX2
initial concentration: NaN
has only substance units: false
type: Species

metaR UDPDOLPT L
reactant: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
modifier: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
fast: false
type: Reaction
reversible: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.117

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaM din e
is: CHEBI:28997
has only substance units: false
name: Deoxyinosine
initial amount: NaN
type: Species
is: C05512
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: HMDB00071
constant: false

metaR KSIt
is: SBO:0000185
name: keratan sulfate I transport, golgi to extracellular
reactant: MODEL1310110058#
reversible: false
fast: false
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM thf m
type: Species
boundary condition: false
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247
is: CHEBI:57453
constant: false
initial amount: NaN
is: C00101
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: HMDB01846

http://identifiers.org/biomodels.db/MODEL1310110058#_fa2bc577_a36e_45e2_b4ea_1d01b3e6df59
boundary condition: true
initial amount: NaN
constant: false
is: O94778
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:343
name: AQP8
has only substance units: false
type: Species

metaR r2361
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110058#
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true

metaM udp c
is: C00015
constant: false
has only substance units: false
is: CHEBI:58223
initial amount: NaN
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
is: HMDB00295
name: UDP
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_6e523577_1f68_4bb9_a2e5_2556d2bad968
name: PFKL:PFKP
type: Species
initial amount: NaN
is: SBO:0000297
constant: false
has part: Q7L2M7
is encoded by: hsa:5211
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR 5ADTSTSTERONEte
kinetic law: MODEL1310110058#
is: SBO:0000185
name: 5 alpha dihydrotesterone transport
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false

metaR r0698
is described by: ECO:0000000
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.27
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#

metaR PSSA2 hs
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.8.29
is described by: ECO:0000269
fast: false
modifier: MODEL1310110058#
reversible: true
is: SBO:0000176
name: Phosphatidylserine synthase homo sapiens
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
reactant: MODEL1310110058#

metaR r0835
product: MODEL1310110058#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110058#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110058#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110058#

metaM c12dc x
initial amount: NaN
type: Species
constant: false
name: dodecanedioyl carnitine
has only substance units: false
notes: FORMULA: C19H34NO6 CHARGE: -1
is: SBO:0000247
is: HMDB03952
is: C05280
initial concentration: 1.0
boundary condition: false

metaM h2o2 e
boundary condition: false
is: SBO:0000247
has only substance units: false
name: hydrogen peroxide
type: Species
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: HMDB03125
is: CHEBI:16240
initial amount: NaN

metaM nad x
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
is: C00003
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57540
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM ala L c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: L-alanine
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: CHEBI:16977
is: HMDB00161
initial amount: NaN
has only substance units: false

metaM sphs1p r
initial amount: NaN
initial concentration: 1.0
type: Species
name: sphingosine 1-phosphate(1-)
is: HMDB00277
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124

metaM cs e deg6 l
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
is: SBO:0000247
boundary condition: false
is: HMDB01354
is: CHEBI:57455
type: Species
notes: FORMULA: C31H48NO32S2 CHARGE: -3
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR FAOXC61m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_cc1227eb_aebf_4a95_bce6_0c4949c92d60
has only substance units: false
constant: false
name: PLCH1
type: Species
is: Q4KWH8
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23007
boundary condition: true
initial concentration: NaN

metaR r2362
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_ed049060_bd27_4753_93ef_4b2b98ef26c5
initial concentration: NaN
has only substance units: false
name: DHCR7
type: Species
boundary condition: true
is: Q9UBM7
constant: false
is encoded by: hsa:1717
initial amount: NaN
is: SBO:0000252

metaR GTHOm
product: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000254
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione oxidoreductase
fast: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reactant: MODEL1310110058#
modifier: MODEL1310110058#

metaR ALACYSNaEx
reversible: false
kinetic law: MODEL1310110058#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110058#
type: Reaction
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110058#

metaR r2363
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110058#

metaM dhea c
initial concentration: 1.0
is: CHEBI:28689
constant: false
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one
is: HMDB00077
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_ca76de05_181b_4f51_846b_67e2a302b340
type: Species
is: Q16719
name: KYNU
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8942
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_805f6365_bd86_4881_9232_53de9fa95e19
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q8IX04
name: UEVLD
type: Species
has only substance units: false
constant: false
is encoded by: hsa:55293

metaR Htx
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: H transporter, peroxisome
kinetic law: MODEL1310110058#

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM dcholcoa r
is: CHEBI:28701
initial amount: NaN
has only substance units: false
constant: false
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
is: HMDB06292
boundary condition: false
type: Species

metaR r0022
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is: SBO:0000176
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000000

metaM ditp n
constant: false
name: dITP(4-)
has only substance units: false
initial concentration: 1.0
is: HMDB03537
boundary condition: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:61382

metaR DNDPt25m
is described by: ECO:0000269
is: SBO:0000185
name: dTDP transport via dCDP antiport
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110058#
reversible: false
modifier: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#

metaR r1647
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM udp r
name: UDP
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
initial amount: NaN
is: CHEBI:58223
is: C00015
initial concentration: 1.0
constant: false

metaR r0723
reversible: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110058#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_6792192f_df53_4505_ac7e_d7eca0074cea
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: Q86V21
boundary condition: true
name: AACS
is encoded by: hsa:65985

metaR r0836
is described by: ECO:0000000
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.5.4.16

metaM chsterol r
has only substance units: false
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: SBO:0000247
initial concentration: 1.0
is: HMDB00067
initial amount: NaN
boundary condition: false
constant: false
name: cholesterol
type: Species

metaR r2364
fast: false
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_80fdadd0_62df_4f43_a4a0_404a10f99508
type: Species
is: P39656
initial amount: NaN
is encoded by: hsa:1650
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: DDOST

metaM amp x
is: SBO:0000247
is: HMDB00045
is: CHEBI:456215
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
name: AMP
is: C00020

metaM coa n
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57287
is: HMDB01423
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
name: coenzyme A(4-)

metaR r1646
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110058#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_6cbb95ab_876f_4776_9c98_100186d566f4
is: B4E0V8
has only substance units: false
name: HAL
type: Species
boundary condition: true
is encoded by: hsa:3034
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaM chlstol r
is: CHEBI:16290
boundary condition: false
initial concentration: 1.0
is: HMDB06842
type: Species
is: SBO:0000247
constant: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial amount: NaN
has only substance units: false

metaM gthox m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
initial concentration: 1.0
is: CHEBI:58297
boundary condition: false
type: Species
is: HMDB03337
initial amount: NaN

metaM 12ppd S c
initial concentration: 1.0
name: (S)-propane-1,2-diol
has only substance units: false
is: SBO:0000247
is: CHEBI:29002
initial amount: NaN
boundary condition: false
is: HMDB06213
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_250d31e0_dee4_433c_9605_891a709654bd
type: Species
is encoded by: hsa:5833
initial concentration: NaN
name: PCYT2
constant: false
is: F5H8B1
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_082c96b9_c836_42b6_a24e_f2ebe19891c1
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: Q96P26
constant: false
is encoded by: hsa:93034
is: SBO:0000252
name: NT5C1B

http://identifiers.org/biomodels.db/MODEL1310110058#_aca2d3b9_1615_4d5d_8465_d48772a649c5
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC24A2
is: Q9UI40
is encoded by: hsa:25769

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110058#
type: Reaction
reversible: true
product: MODEL1310110058#

metaM occoa m
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57386
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
is: HMDB01070

metaM nad r
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57540
name: NAD(1-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: HMDB00902
boundary condition: false
constant: false
type: Species

metaM dolmanp L r
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
is: CHEBI:15809
type: Species
initial concentration: 1.0
boundary condition: false

metaR r2365
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#

metaR ATPS4m
fast: false
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
is version of: http://identifiers.org/ec-code/3.6.3.14
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.1.14
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.6.4.6
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110058#
name: ATP synthase (four protons for one ATP)

metaM coa m
initial concentration: 1.0
is: CHEBI:57287
constant: false
name: Coenzyme A
is: HMDB01423
is: SBO:0000247
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_c89e7b99_a931_49bc_a4fa_3ae58e384dce
name: ALAS1
boundary condition: true
is: Q5JAM2
initial amount: NaN
is encoded by: hsa:211
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR G14T15g
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
is: SBO:0000176
modifier: MODEL1310110058#

metaR r1649
kinetic law: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#
fast: false

metaR r0838
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
product: MODEL1310110058#
type: Reaction
fast: false
reversible: true
name: Free diffusion
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.2.4
is described by: ECO:0000000
modifier: MODEL1310110058#

metaR r2366
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110058#
fast: false

metaM clpn hs c
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
name: cardiolipin
type: Species
boundary condition: false
is: CHEBI:28494
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR r0021
is: SBO:0000176
product: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110058#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7

metaR RE1521M
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110058#
name: RE1521
is: SBO:0000176
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_c96ce38c_e2e3_4ee4_bac5_34ea637da037
is: SBO:0000252
type: Species
is: O75489
boundary condition: true
is encoded by: hsa:4722
constant: false
initial concentration: NaN
name: NDUFS3
initial amount: NaN
has only substance units: false

metaR r1648
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110058#
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_a047954e_3f02_4034_b220_ce85ac759de9
constant: false
is encoded by: hsa:H17063
initial concentration: NaN
boundary condition: true
name: _H17063_1_c
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

metaR r0839
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
reactant: MODEL1310110058#
product: MODEL1310110058#
name: Postulated transport reaction
modifier: MODEL1310110058#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_fd4dbca2_33e3_4408_8baf_504bebc25375
has only substance units: false
initial concentration: NaN
name: ACSL1
boundary condition: true
is encoded by: hsa:2180
is: P33121
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaR r0726
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
fast: false
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176

metaR UGLCNACtg
modifier: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false
name: UDP-GlcNAc Golgi transport via CMP antiport

metaM sucr e
name: Sucrose
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: C00089
is: SBO:0000247
constant: false
is: CHEBI:17992
has only substance units: false
is: HMDB00258
initial concentration: 1.0
initial amount: NaN
type: Species

metaM q10 c
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:46245
is: HMDB01072
constant: false

metaR r1643
is: SBO:0000185
modifier: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
fast: false

metaR GLCAASE7ly
reactant: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110058#
reversible: false
name: beta-glucuronidase, lysosomal
is: SBO:0000176

metaM bilglcur r
is: SBO:0000247
initial concentration: 1.0
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57767

metaR ICDHyrm
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110058#
reversible: true
name: Isocitrate dehydrogenase (NADP+)
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
fast: false

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
product: MODEL1310110058#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
type: Reaction

metaR HAS2
type: Reaction
reversible: false
fast: false
is: SBO:0000185
modifier: MODEL1310110058#
name: hyaluronan synthase
is version of: http://identifiers.org/ec-code/2.4.1.212
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_80820d0a_8796_4053_aa7c_966eabd2291d
has only substance units: false
name: AK4
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:205
boundary condition: true
is: SBO:0000252
type: Species

metaM xoldiolone r
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB02197
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial concentration: 1.0
is: CHEBI:28477
boundary condition: false

metaR r1968
kinetic law: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110058#
name: Y+LAT2 Utilized transport
product: MODEL1310110058#

metaM nad m
constant: false
type: Species
is: SBO:0000247
is: C00003
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
has only substance units: false
name: Nicotinamide adenine dinucleotide
is: CHEBI:57540

http://identifiers.org/biomodels.db/MODEL1310110058#_b9abba85_268b_4fd4_b8d9_185f732bbbb2
has only substance units: false
constant: false
boundary condition: true
is: O60331
type: Species
is encoded by: hsa:23396
initial concentration: NaN
name: PIP5K1C
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_6e7575be_5001_4211_aab9_e6ee233d8553
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4128
is: Q53YE7
has only substance units: false
type: Species
name: MAOA

metaR NDPK7n
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
kinetic law: MODEL1310110058#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_f37eb3b7_7c45_458b_b2c1_403d37bddfa4
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P30519
boundary condition: true
name: HMOX2
is encoded by: hsa:3163

http://identifiers.org/biomodels.db/MODEL1310110058#_b7065a7c_74db_46af_99c6_303072c30740
is encoded by: hsa:11001
is: SBO:0000252
type: Species
constant: false
is: O14975
name: SLC27A2
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_fb85ce5f_b5da_4800_9af5_ee5366318c93
has only substance units: false
is encoded by: hsa:2954
initial concentration: NaN
constant: false
name: GSTZ1
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: O43708

metaM udp n
is: CHEBI:58223
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
constant: false
initial amount: NaN
is: SBO:0000247

metaR r1642
type: Reaction
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true

metaR r0156
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:

metaM coa r
boundary condition: false
name: Coenzyme A
initial amount: NaN
is: HMDB01423
constant: false
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
is: CHEBI:57287
initial concentration: 1.0
is: C00010
type: Species

metaR HAS1
product: MODEL1310110058#
name: hyaluronan synthase
type: Reaction
reactant: MODEL1310110058#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.212
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
fast: false
is: SBO:0000185
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#

metaR r2368
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110058#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110058#
reversible: true

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR NRPPHRSULT
modifier: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000269
name: Norepinephrine Sulfotransferase
kinetic law: MODEL1310110058#
reversible: false
product: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.1
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

metaR Htr
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: H transporter, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_6203f6bd_35f7_430a_af33_9785620db204
constant: false
boundary condition: true
is encoded by: hsa:8527
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: DGKD
initial amount: NaN

metaM h2o2 m
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
has only substance units: false
is: C00027
is: CHEBI:16240
type: Species
is: HMDB03125
constant: false
initial concentration: 1.0
name: Hydrogen peroxide
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_53ff6e29_7752_4bbe_84ae_043104770ef5
initial amount: NaN
is: P22392
has only substance units: false
is encoded by: hsa:4831
is: SBO:0000252
constant: false
initial concentration: NaN
name: NME2
type: Species
boundary condition: true

metaM HC02176 e
notes: FORMULA: C12H23O2 CHARGE: -1 INCHI: InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)/p-1 EHMN_ABBREVIATION: C02679
name: laurate
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18262
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaM q10 e
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: CHEBI:46245
name: ubiquinone-10
initial concentration: 1.0
constant: false
is: HMDB01072
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaR MDHx
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
name: malate dehydrogenase, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
kinetic law: MODEL1310110058#
reversible: true

metaR MANter
fast: false
kinetic law: MODEL1310110058#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110058#
name: mannose efflux from endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110058#

metaR KHK
reversible: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.1.3
name: ketohexokinase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110058#

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR r2369
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110058#

metaR LGNCCOAtx
reactant: MODEL1310110058#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#

metaR TCYNTtm
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000185
name: Thiocyanate transport via diffusion (mitochondrial)
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
type: Reaction
reactant: MODEL1310110058#
fast: false

metaR B3GNT39g
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
reversible: false
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110058#_ef1558b8_4d9d_4446_9b74_d8d63c378505
type: Species
is encoded by: hsa:53354
name: PANK1
initial concentration: NaN
boundary condition: true
is: Q8TE04
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

metaM ksi pre27 g
initial amount: NaN
is: CHEBI:58053
is: C00130
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 27
is: HMDB00175
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
has only substance units: false

metaR PPCOAOm
reactant: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
fast: false
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_f7916bb8_cc07_49b0_bfe4_0ab98a480374
boundary condition: true
constant: false
is: O95169
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: NDUFB8
is encoded by: hsa:4714

http://identifiers.org/biomodels.db/MODEL1310110058#_d2694f74_14fa_4f5e_8830_895cf8b8fab6
is: SBO:0000252
name: BAAT
constant: false
has only substance units: false
type: Species
is encoded by: hsa:570
initial amount: NaN
initial concentration: NaN
is: Q14032
boundary condition: true

metaM thf e
is: SBO:0000247
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01846

http://identifiers.org/biomodels.db/MODEL1310110058#_5a777db2_2186_4501_b869_d2f8ebbde4dd
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: _M68895_1_c
boundary condition: true
initial amount: NaN
is encoded by: hsa:M68895

metaM udp l
is: CHEBI:58223
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
is: HMDB00295

metaR r1645
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#

metaR r1644
type: Reaction
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
modifier: MODEL1310110058#

metaR AG13T11g
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
modifier: MODEL1310110058#

metaR KAS8
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
modifier: MODEL1310110058#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#

metaR GCCcm
name: glycine-cleavage complex (lipoylprotein), mitochondrial
reversible: true
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
product: MODEL1310110058#
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176

metaR r0722
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.3.12
is: SBO:0000176
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: true
product: MODEL1310110058#

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_6fdbaa7a_b473_481c_8844_30974f848f32
initial concentration: NaN
has only substance units: false
constant: false
name: PLCG1
type: Species
is encoded by: hsa:5335
boundary condition: true
is: Q9UFY1
initial amount: NaN
is: SBO:0000252

metaR RE3003M
reactant: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
modifier: MODEL1310110058#
fast: false
is: SBO:0000176
product: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3003
kinetic law: MODEL1310110058#

metaM amp r
initial amount: NaN
is: C00020
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
name: AMP
is: CHEBI:456215
initial concentration: 1.0

metaR RE2999M
name: RE2999
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110058#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_8dca8a61_417d_49c5_9dc9_b0bbf4d19b4d
type: Species
is: P11310
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:34
is: SBO:0000252
name: ACADM
constant: false
has only substance units: false

metaR O16G1e
kinetic law: MODEL1310110058#
product: MODEL1310110058#
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.10
modifier: MODEL1310110058#
reversible: false

metaM dmnoncrn c
is: HMDB06202
boundary condition: false
notes: FORMULA: C18H37NO4 CHARGE: 0
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: 4,8-dimethylnonanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110058#_5ee04b76_1a1a_4404_9fa8_1fda9528d895
boundary condition: true
name: MAN2A2
is: Q9P1E4
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:4122
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_7b245631_58ee_4c10_aa53_664efdfc6d94
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:8803
has only substance units: false
has part: E5KS60
name: SUCLG1:SUCLA2
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR HACD1m
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
fast: false
reversible: true
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b6958f32_17a9_478d_92b3_6fbab320eb23
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:549
name: AUH
constant: false
initial concentration: NaN
boundary condition: true
is: Q13825

metaR CSNt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
product: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
fast: false
name: cytosine transport via facilated diffusion
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_9235bb6e_2d37_4341_8338_640d2df8a5d4
initial concentration: NaN
name: SC5DL
has only substance units: false
initial amount: NaN
type: Species
is: Q6GTM5
is encoded by: hsa:6309
is: SBO:0000252
boundary condition: true
constant: false

metaM strdnc e
name: stearidonic acid C18:4, n-3
has only substance units: false
type: Species
is: HMDB06547
is: C16300
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
initial amount: NaN

metaM nrpphrsf e
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/123747
boundary condition: false
is: HMDB02062
initial concentration: 1.0
name: Sulfate derivative of norepinephrine
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: SBO:0000247
has only substance units: false
type: Species

metaR r2139
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110058#
type: Reaction
fast: false
reactant: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110058#

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM hco3 m
is: C00288
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:17544
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
name: Bicarbonate

metaM adn c
has only substance units: false
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: HMDB00050
initial amount: NaN
is: C00212
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: Adenosine

http://identifiers.org/biomodels.db/MODEL1310110058#_506a4769_9328_4ad7_845f_8d1768a2e645
is: O95954
name: FTCD
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:10841
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_9150dded_89ea_4078_acec_e47a54e94a6c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7108
constant: false
is: O76062
type: Species
is: SBO:0000252
boundary condition: true
name: TM7SF2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_275b69bf_ac97_44df_a686_99b1c897ce68
is: A5JJ20
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8671
has only substance units: false
name: SLC4A4

metaR MCCCrm
kinetic law: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/6.4.1.4
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
reversible: true
reactant: MODEL1310110058#
product: MODEL1310110058#
name: methylcrotonoyl-CoA carboxylase, mitochondrial
is: SBO:0000176
is described by: ECO:0000269

metaM ach n
type: Species
name: acetylcholine
is: HMDB00895
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
is: SBO:0000247
is: CHEBI:15355

metaM aacoa m
is: CHEBI:57286
is: SBO:0000247
has only substance units: false
name: acetoacetyl-CoA(4-)
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
constant: false
is: HMDB01484
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaM cmpacna c
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false
type: Species
is: CHEBI:57812
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR FAOXC161C141x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaM dgtp n
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
name: dGTP
is: HMDB01440
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: C00286

metaR RE2626C
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is: SBO:0000176
name: RE2626
fast: false
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_28e87931_84dd_4daa_9454_1f68d2bae8b4
name: OGDH
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: B4E3E9
is encoded by: hsa:4967
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_94dda08f_3041_4dd8_b6cf_47c4b54b60e8
boundary condition: true
is: Q9UJM8
type: Species
name: HAO1
is encoded by: hsa:54363
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_ef09cfd0_2b48_491d_85d3_8c59141d02a2
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:10317
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: B3GALT5

http://identifiers.org/biomodels.db/MODEL1310110058#_87047136_012e_42cc_be9b_cbd4b3269710
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: ADH1B
is encoded by: hsa:125
has only substance units: false
is: P00325

metaM ksi pre34 g
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: CHEBI:58053
is: C00130
is: HMDB00175
has only substance units: false
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 34
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r2137
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
fast: false
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: true
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_86e3f059_a185_4431_b9ba_aaaa3fb5fb85
name: ALDH2
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:217
initial amount: NaN
has only substance units: false
is: P05091
initial concentration: NaN
boundary condition: true

metaR CYANtm
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Cyanide transport via diffusion (mitochondrial)
is described by: ECO:0000000
reactant: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
reversible: true
type: Reaction
is: SBO:0000185

metaM xyl D l
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:15936
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false
initial concentration: 1.0
is: SBO:0000247
name: aldehydo-D-xylose

metaR PAIL4P HStn
is: SBO:0000185
kinetic law: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
reversible: true
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_9a56b895_bf32_4991_9cd7_4b971862d285
initial concentration: NaN
has only substance units: false
constant: false
is: Q15392
initial amount: NaN
boundary condition: true
name: DHCR24
is: SBO:0000252
is encoded by: hsa:1718
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_e7b32a16_c45d_4f1c_a19b_009545eb841f
has only substance units: false
type: Species
is: SBO:0000252
is: A8K0S7
constant: false
initial concentration: NaN
is encoded by: hsa:2542
boundary condition: true
initial amount: NaN
name: SLC37A4

metaM c81crn e
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
name: octenoyl carnitine
initial concentration: 1.0
notes: FORMULA: C15H27NO4 CHARGE: 0
is: HMDB13324
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_62825e0b_827a_46c2_8b72_444b0de4f31f
constant: false
is encoded by: hsa:1119
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P35790
is: SBO:0000252
name: CHKA

http://identifiers.org/biomodels.db/MODEL1310110058#_d9a268cf_b8eb_4274_80b4_5b675b36bd6c
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4842
initial concentration: NaN
type: Species
constant: false
name: NOS1
is: B4DG68
boundary condition: true

metaM 7dhf c
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB06559
name: heptaglutamyl folate (DHF)
initial concentration: 1.0
type: Species
has only substance units: false

metaR GCCam
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110058#
fast: false
reversible: true
reactant: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
name: glycine-cleavage complex (lipoylprotein), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269

metaR NADPHtru
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: NADPH transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
fast: false
reactant: MODEL1310110058#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR r2136
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

metaR NRPPHRtu
is described by: ECO:0000269
reversible: true
product: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
name: Norepinephrine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110058#_680c0186_396e_41ab_bc09_3746eb4c5c82
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:53354
is: Q8TE04
initial concentration: NaN
type: Species
constant: false
name: PANK1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_02b54639_8a12_4eab_a4cc_0e4117701bf1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _AA177072_1_c
is encoded by: hsa:AA177072
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR 5MTHFt2le
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: 5-methyltetrahydrofolate transport via anion exchange
reactant: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_b60fe739_7d32_4e4f_b607_6385a8123e58
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: LDHB
is: P07195
initial amount: NaN
boundary condition: true
is encoded by: hsa:3945

metaR BILIRED
modifier: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
name: Nad(p)h biliverdin reductase
fast: false
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.24
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction

metaR ILETA
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is described by: ECO:0000269
reversible: true
is: SBO:0000176
modifier: MODEL1310110058#
name: isoleucine transaminase
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_d4062087_b28a_40f8_ba6e_ba32ccd15084
has part: Q99519
has part: P34059
boundary condition: true
is encoded by: hsa:5476
has part: P10619
initial amount: NaN
constant: false
is encoded by: hsa:2588
is: SBO:0000297
initial concentration: NaN
has part: P16278
has only substance units: false
is encoded by: hsa:2720
is encoded by: hsa:4758
name: GALNS:GLB1:NEU1:CTSA
type: Species

metaR TSTSTERONEt
is: SBO:0000185
name: Testosterone transport
product: MODEL1310110058#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110058#
is described by: ECO:0000269
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_785c4e4e_8465_4445_b870_5049406e01e7
name: COX7A1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P24310
initial amount: NaN
is encoded by: hsa:1346
constant: false
type: Species
boundary condition: true

metaM o2s m
initial amount: NaN
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
constant: false
type: Species
name: Superoxide anion
has only substance units: false
is: CHEBI:18421
is: HMDB02168
is: C00704
initial concentration: 1.0

metaR PPD2CSPp
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
is: SBO:0000176
fast: false
name: PPD2CSPp
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#

metaR G14T11g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: false

metaM c81crn c
name: octenoyl carnitine
notes: FORMULA: C15H27NO4 CHARGE: 0
initial amount: NaN
is: HMDB13324
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

metaR r2021
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110058#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_1baeb235_257c_4fde_890b_ace6bd695317
initial amount: NaN
name: AK1
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:203
is: P00568
type: Species
boundary condition: true

metaM 7dhf e
boundary condition: false
type: Species
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
name: heptaglutamyl folate (DHF)
initial concentration: 1.0
is: HMDB06559

http://identifiers.org/biomodels.db/MODEL1310110058#_ecb875c1_b210_4168_9324_7e2105d756c4
initial amount: NaN
is encoded by: hsa:1603
type: Species
initial concentration: NaN
is encoded by: hsa:6184
has part: P39656
has part: Q53G02
is encoded by: hsa:6185
is: SBO:0000297
has only substance units: false
constant: false
boundary condition: true
has part: P04844
has part: P04843
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:1650

metaR PRISTCOAtcx
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM HC00822 l
has only substance units: false
name: Chitobiose
type: Species
initial amount: NaN
is: CHEBI:28681
initial concentration: 1.0
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
boundary condition: false
constant: false
is: SBO:0000247

metaM cmpacna g
is: CHEBI:57812
has only substance units: false
initial concentration: 1.0
is: HMDB01176
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_6e1f8b10_e08d_4a27_bf0c_5eb9bcecab9b
is: Q5VYT2
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4712
is: SBO:0000252
name: NDUFB6
type: Species
initial amount: NaN

metaM tststerone r
initial concentration: 1.0
name: testosterone
is: CHEBI:17347
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
is: SBO:0000247
is: HMDB00234
type: Species
constant: false
initial amount: NaN

metaM gluside hs g
is: CHEBI:18368
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_7867efff_1514_49f4_9290_cb43e0947e50
initial concentration: NaN
constant: false
type: Species
is: G3XA95
has only substance units: false
initial amount: NaN
is encoded by: hsa:8611
is: SBO:0000252
name: PPAP2A
boundary condition: true

metaR r2020
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
reversible: false

metaR r2133
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110058#
is: SBO:0000185
fast: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR r1940
type: Reaction
kinetic law: MODEL1310110058#
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110058#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110058#
product: MODEL1310110058#

metaR r2359
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true

metaR DOCO13EFATP
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR METAT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reversible: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.5.1.6
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: methionine adenosyltransferase
reactant: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (4143.1) or (27430.2 and 4144.1) or (27430.1 and 4144.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR XYLtly
is: SBO:0000185
type: Reaction
reactant: MODEL1310110058#
product: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: Xylose efflux from lysosome
is described by: ECO:0000000
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_cb7d0f50_9d22_4265_84a4_7ac6155ba840
is: Q9HBH5
boundary condition: true
name: RDH14
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:57665
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_6938aaae_92c2_47e1_b170_23b6df7faadc
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9UJS0
name: SLC25A13
is encoded by: hsa:10165
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_c00858ad_dd42_42c0_b675_c0f37fb5cc24
is: Q9UIG8
boundary condition: true
initial amount: NaN
name: SLCO3A1
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:28232
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_8c5acbfd_a5f5_45d7_a655_f47d869f911b
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q6ZMR3
is encoded by: hsa:160287
name: LDHAL6A

metaR r2132
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR VD3
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
fast: false
product: MODEL1310110058#
name: Vitamin D3 formation
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110058#_a79fb89d_6f06_4a59_97d8_135cbb17a451
type: Species
initial concentration: NaN
name: HMGCR
has only substance units: false
initial amount: NaN
is: P04035
boundary condition: true
is encoded by: hsa:3156
constant: false
is: SBO:0000252

metaR RE3566C
name: RE3566
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110058#
fast: false
is: SBO:0000176
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_6c2481df_fd13_4242_9bb0_09f52cb5856e
initial concentration: NaN
name: SLC28A3
is encoded by: hsa:64078
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9HAS3
boundary condition: true

metaR RE2972M
modifier: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true
name: RE2972
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.1.67

metaM hexdectecoa m
is: HMDB02288
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 2,4,7,10-hexadecatetraenoylcoa
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_c91f9374_54a2_4d47_be26_f0bf10fd7004
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:286297
boundary condition: true
name: _286297_1_c
initial concentration: NaN
constant: false

metaR RE2677E
type: Reaction
product: MODEL1310110058#
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
is described by: ECO:0000000
name: RE2677
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaM dcholcoa c
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
type: Species
has only substance units: false
constant: false
is: CHEBI:28701

metaM dgtp c
initial concentration: 1.0
type: Species
name: dGTP
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:16497
boundary condition: false
is: C00286

metaM ksi pre3 g
is: CHEBI:58053
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: HMDB00175
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00130
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 3
constant: false
is: SBO:0000247

metaM cmpacna n
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: CHEBI:57812
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)

http://identifiers.org/biomodels.db/MODEL1310110058#_9664bdd8_677c_40aa_814a_ae649a2ce945
is: P09848
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:3938
type: Species
boundary condition: true
name: LCT

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR r2131
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110058#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110058#
reversible: true
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_2ddd5cfe_40dd_4e78_8dba_63aeb94f4e04
initial amount: NaN
is: P11168
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC2A2
is encoded by: hsa:6514
boundary condition: true
has only substance units: false
constant: false

metaR RE0453N
name: RE0453
modifier: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#

metaM gluside hs c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18368
type: Species
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaR ACt2r
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
kinetic law: MODEL1310110058#
reversible: true
name: acetate reversible transport via proton symport
reactant: MODEL1310110058#
fast: false

metaM ha deg1 l
name: hyaluronan degradation product 1
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C22H33N2O16 CHARGE: -1
is: SBO:0000247
is: CHEBI:16336
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_acedeedf_d7b3_451b_b3a4_ba1d9154e080
is encoded by: hsa:4830
has only substance units: false
initial concentration: NaN
name: NME1
is: P15531
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaM 2hb e
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00008
name: 2-Hydroxybutyrate
is: CHEBI:1148
constant: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: SBO:0000247
initial concentration: 1.0

metaM cyst L c
notes: FORMULA: C7H14N2O4S CHARGE: 0 INCHI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00916
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00099
constant: false
initial amount: NaN
type: Species
is: CHEBI:17482
name: L-cystathionine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_5e9d8ee9_734b_413e_a0a5_72950029f1c9
has part: P31040
has part: O14521
is encoded by: hsa:6390
boundary condition: true
is encoded by: hsa:6392
has only substance units: false
is: SBO:0000297
is encoded by: hsa:6391
has part: Q99643
has part: P21912
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6389

metaM tststerone e
name: testosterone
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
has only substance units: false
is: HMDB00234
constant: false
is: CHEBI:17347

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM xyl D e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:15936
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
constant: false

metaR r2130
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110058#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reversible: true

metaR PMANM
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
name: phosphomannomutase
is version of: http://identifiers.org/ec-code/5.4.2.8
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/5.4.2.2
product: MODEL1310110058#
fast: false
type: Reaction

MODEL1310110058#
species: metaM CE4872 c
species: metaM tmndnc c
species: metaM btn e
species: metaM sql r
species: metaM retinol e
species: metaM asp D x
species: metaM octa e
species: metaM ac c
species: metaM arachd l
species: metaM HC02187 e
species: metaM biliverd c
species: metaM zymstnl r
species: metaM CE2434 m
species: metaM acmanap c
species: metaM dcholcoa x
species: metaM asp D c
species: metaM hexdicoa r
species: metaM ksii core2 g
species: metaM 6a2ohxnt x
species: metaM guln c
species: metaM 1pyr5c m
species: metaM idour c
stoichiometry: 0.055374
species: metaM acnam n
species: metaM pail345p hs c
species: metaM fn2m2masn g
species: metaM cys L c
species: metaM Lpipecol x
species: metaM ala B e
species: metaM ksi pre3 g
species: metaM cdpchol c
species: metaM nad x
species: metaM hom L c
species: metaM ptrc e
species: metaM glyc m
species: metaM 56dura c
species: metaM dcsptn1 c
species: metaM Ssq23epx r
species: metaM h2o2 e
species: metaM acnacngalgbside hs g
species: metaM nad c
species: metaM cit m
species: metaM 2obut m
species: metaM tdcoa c
species: metaM but e
species: metaM 4mptnl m
species: metaM cs a l
species: metaM c16dc e
species: metaM prostgd2 c
species: metaM tetpent6 c
species: metaM ser D c
species: metaM 3mob m
species: metaM 10fthf e
species: metaM dgsn c
species: metaM pristcoa c
species: metaM CE4872 m
species: metaM vacccoa c
species: metaM c16dc c
species: metaM HC02216 e
species: metaM xol7ah2 c
species: metaM glcur e
has only substance units: false
species: metaM ksii core2 pre2 g
species: metaM ppcoa m
species: metaM HC01459 x
species: metaM 3ohdcoa m
species: metaM ac m
species: metaM lac D c
species: metaM itp n
multipler: 1.0
species: metaM 5adtststerone c
species: metaM guln r
species: metaM adrncoa m
species: metaM hdd2coa x
species: metaM dcyt n
species: metaM xan c
species: metaM acgal c
species: metaM CE0713 m
species: metaM ribflv e
species: metaM ins c

metaM homoval m
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:545959
is: HMDB00118
has only substance units: false
name: Homovanillate
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582

http://identifiers.org/biomodels.db/MODEL1310110058#_41bc708d_e43f_4b8f_8ffb_715b29240385
boundary condition: true
initial amount: NaN
is encoded by: hsa:81031
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC2A10
is: O95528

metaM retinol 9 cis c
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: HMDB06217
name: 9-cis-retinol
has only substance units: false
is: CHEBI:17336
initial amount: NaN
type: Species

metaM Rtotalcoa c
has only substance units: false
constant: false
type: Species
name: R total Coenzyme A
initial amount: NaN
boundary condition: false
is: CHEBI:16189
is: HMDB01448
initial concentration: 1.0
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: SBO:0000247

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR CHOLt4
fast: false
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
type: Reaction
name: choline, sodium cotransport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_2a0fed42_de38_4729_ac86_19acde3a239f
initial concentration: NaN
is: Q7LG56
name: RRM2B
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:50484
is: SBO:0000252

metaM dgtp e
boundary condition: false
is: CHEBI:16497
has only substance units: false
constant: false
initial concentration: 1.0
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01440

http://identifiers.org/biomodels.db/MODEL1310110058#_5fabbee4_b8a0_4872_be63_748faf124bf4
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:114799
name: ESCO1
boundary condition: true
initial amount: NaN
is: Q5FWF5
constant: false

metaM o2s c
has only substance units: false
boundary condition: false
constant: false
name: superoxide
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
is: SBO:0000247
initial amount: NaN
is: HMDB02168
initial concentration: 1.0

metaM 7dhf l
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial amount: NaN
initial concentration: 1.0
is: HMDB06559
name: heptaglutamyl folate (DHF)
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false

metaM 2hb c
is: HMDB00008
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: CHEBI:1148
initial concentration: 1.0
name: 2-Hydroxybutyrate
has only substance units: false
type: Species

metaM pmtcrn c
has only substance units: false
constant: false
is: HMDB00222
initial amount: NaN
is: CHEBI:17490
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaM 5HPET c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: 5(S)-HPETE(1-)
is: HMDB01193
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:57450

metaM tyr L e
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:17895
name: L-tyrosine
boundary condition: false
has only substance units: false
is: HMDB00158
initial concentration: 1.0
constant: false

metaM tdcrn e
boundary condition: false
name: myristoyl carnitine
initial concentration: 1.0
notes: FORMULA: C21H41NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
type: Species
is: HMDB05066
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_64cd1394_bb19_4047_a7df_1a2ce09293b4
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: SLC4A10
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: B7Z1R0
is encoded by: hsa:57282

metaR FATP9t
fast: false
product: MODEL1310110058#
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.7

metaM mescon m
is: CHEBI:36986
constant: false
type: Species
boundary condition: false
is: HMDB00749
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Mesaconate

metaM 7dhf m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: heptaglutamyl folate (DHF)
constant: false
is: HMDB06559
has only substance units: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1

metaR DOLP Lter
reversible: false
type: Reaction
name: dolichol phosphate flippase (liver)
is: SBO:0000176
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000

metaR r0129
is described by: ECO:0000000
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110058#
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176

metaM HC00822 e
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28681
name: Chitobiose
has only substance units: false
initial amount: NaN
type: Species

metaM o2s e
name: superoxide
is: CHEBI:18421
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
type: Species
constant: false
has only substance units: false
is: HMDB02168
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR FMNALKPle
is: SBO:0000176
reactant: MODEL1310110058#
name: FMNALKPle
kinetic law: MODEL1310110058#
reversible: false
product: MODEL1310110058#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

metaM nh4 m
has only substance units: false
initial concentration: 1.0
type: Species
name: Ammonium
is: HMDB00051
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
boundary condition: false
is: CHEBI:28938
is: C01342
initial amount: NaN

metaM mlthf m
is: C00143
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15636
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
name: 5,10-Methylenetetrahydrofolate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_13899778_03bf_4f43_8c7c_695b26728fcb
name: ST3GAL2
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6483
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q16842
boundary condition: true

metaM glutcoa c
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: HMDB01339
has only substance units: false
initial amount: NaN
name: glutaryl-CoA(5-)
boundary condition: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1

metaM tyr L c
constant: false
type: Species
name: L-tyrosine
has only substance units: false
is: CHEBI:17895
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

metaR GTHPm
product: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.12
modifier: MODEL1310110058#
name: glutathione peroxidase, mitochondria
fast: false
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110058#
type: Reaction

metaM tdcrn c
initial concentration: 1.0
is: HMDB05066
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: myristoyl carnitine
notes: FORMULA: C21H41NO4 CHARGE: 0

metaR PCt
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
product: MODEL1310110058#
reactant: MODEL1310110058#
fast: false
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110058#
reversible: true
name: phosphatidylcholine transporter
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.6.3.44

metaR OCCOAtx
reversible: true
name: fatty acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110058#

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM nh4 n
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00051
name: ammonium
type: Species
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
has only substance units: false

metaM adn e
is: CHEBI:16335
is: HMDB00050
initial concentration: 1.0
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false
constant: false
type: Species
is: C00212
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110058#_ce348ee0_dc0f_41c9_9756_eeb50cd16974
constant: false
has only substance units: false
is encoded by: hsa:1327
initial amount: NaN
name: COX4I1
type: Species
is: SBO:0000252
is: P13073
boundary condition: true
initial concentration: NaN

metaR HSD3B7P
fast: false
reactant: MODEL1310110058#
is: SBO:0000176
reversible: false
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.1.1.181
product: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR DHCR242r
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
kinetic law: MODEL1310110058#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 24-dehydrocholesterol reductase [Precursor]
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR FAOXC15ATPx
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaR ACt2m
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110058#
name: acetate mitochondrial transport via proton symport
reactant: MODEL1310110058#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110058#_34dbe276_bddd_4de5_893f_d461a291e857
type: Species
initial amount: NaN
is encoded by: hsa:1468
has only substance units: false
initial concentration: NaN
name: SLC25A10
constant: false
boundary condition: true
is: Q9UBX3
is: SBO:0000252

metaM dodecanac x
initial amount: NaN
notes: FORMULA: C12H20O4 CHARGE: -2
is: HMDB00623
name: Dodecanedioic acid
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaM aacoa x
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: CHEBI:57286
constant: false
initial concentration: 1.0
name: acetoacetyl-CoA(4-)
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_a6f905c9_7f1f_4cde_a1b7_0f0e9aa2c60e
constant: false
initial amount: NaN
is: SBO:0000252
is: P37837
initial concentration: NaN
is encoded by: hsa:6888
type: Species
name: TALDO1
boundary condition: true
has only substance units: false

metaR INSTt4
name: inositol transport via sodium symport
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_b7d12e17_9592_4d77_89e2_bee36b6d5f76
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:58510
constant: false
boundary condition: true
name: PRODH2
is: Q9UF12
is: SBO:0000252
type: Species

metaR r1291
is described by: ECO:0000000
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Postulated transport reaction
product: MODEL1310110058#
is: SBO:0000185
type: Reaction

metaM urcan c
type: Species
is: HMDB00301
constant: false
is: CHEBI:17771
initial concentration: 1.0
name: Urocanate
boundary condition: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: C00785
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR TREHe
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110058#
reversible: false
type: Reaction
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.2.1.28
reactant: MODEL1310110058#
name: alpha,alpha-trehalase

metaR CRNt
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
name: L-carnitine reversible transport
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269

metaR FBA
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.1.2.13
name: fructose-bisphosphate aldolase
is: SBO:0000176
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
type: Reaction
reversible: true
is described by: ECO:0000134

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_101f6051_5073_4448_8c30_be09501082a0
type: Species
name: GUK1
is: SBO:0000252
is: Q16774
boundary condition: true
has only substance units: false
is encoded by: hsa:2987
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_383f396e_7cbf_4733_8207_0003e49cec3c
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8818
is: SBO:0000252
type: Species
name: DPM2

http://identifiers.org/biomodels.db/MODEL1310110058#_47c0f630_53e0_4da4_a773_98c3da333411
boundary condition: true
name: CS
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is encoded by: hsa:1431
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_6e9d7627_f41d_495c_8602_1bcab7ba1d89
has only substance units: false
is: SBO:0000252
is: P54687
initial amount: NaN
is encoded by: hsa:586
initial concentration: NaN
boundary condition: true
name: BCAT1
constant: false
type: Species

metaM pnto R e
initial amount: NaN
is: CHEBI:7916
has only substance units: false
is: HMDB00210
name: (R)-Pantothenate
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_c829948f_eae1_46cf_8929_4a5ce7792451
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
name: NNT
initial concentration: NaN
is encoded by: hsa:23530

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_18ea7119_d357_4685_84dc_08868484cb75
boundary condition: true
is encoded by: hsa:5152
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: PDE9A
is: SBO:0000252
has only substance units: false

metaR GLCAASE4ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110058#
product: MODEL1310110058#

metaM pmtcrn x
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: L-palmitoylcarnitine
constant: false
is: HMDB00222
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
type: Species

metaR NADH2 u10m
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.6.5.3
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
name: NADH dehydrogenase, mitochondrial
reversible: false
kinetic law: MODEL1310110058#
is: SBO:0000185
type: Reaction
product: MODEL1310110058#
modifier: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…

metaR LEUKTRD4t
name: leukotriene D4 transport
type: Reaction
fast: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:

metaR GALK
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/2.7.1.157
reactant: MODEL1310110058#
reversible: false
is described by: ECO:0000000
fast: false
name: galactokinase
is version of: http://identifiers.org/ec-code/2.7.1.6
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110058#

metaR DNDPt32m
reactant: MODEL1310110058#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
name: dGDP transport via ATP antiport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110058#_2b099a9c_901d_4f77_a93c_922ad60cd0c7
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: B4GALT2
is encoded by: hsa:8704
has only substance units: false

metaM ksii core2 pre8 g
boundary condition: false
type: Species
name: keratan sulfate II biosynthesis, precursor 8
is: CHEBI:58053
is: C00130
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: HMDB00175
constant: false

metaM tetdec2coa c
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial concentration: 1.0
name: tetradecadienoylcoa
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: HMDB02014
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_910533a1_7d27_446b_9bc7_b33da34509bd
name: PLCB2
is: Q59F77
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5330
boundary condition: true
initial amount: NaN
type: Species
constant: false

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.48
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR FAOXC8C6x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

metaM dhcholestancoa x
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0
boundary condition: false
is: CHEBI:15494
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB02159
type: Species

metaR RE0926E
name: RE0926
reactant: MODEL1310110058#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110058#_100f6bc3_854f_4bd3_9704_cce6972336ec
is: P14618
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: PKM2
is: SBO:0000252
is encoded by: hsa:5315

metaR PTDCACRNCPT2
modifier: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: pentadecanoate transport into the mitochondria

metaM pnto R c
is: HMDB00210
is: SBO:0000247
type: Species
name: (R)-Pantothenate
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
is: CHEBI:7916

metaR C121CPT1
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR r1292
type: Reaction
product: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110058#
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_a9d49d96_f876_4a35_8dff_916c43fa0d81
boundary condition: true
is: SBO:0000252
is: Q9UGH3
type: Species
name: SLC23A2
initial amount: NaN
constant: false
is encoded by: hsa:9962
has only substance units: false
initial concentration: NaN

metaR PTDCACRNCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
reactant: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110058#
reversible: false
is: SBO:0000176
name: carnitine fatty-acyl transferase
kinetic law: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_17b9d9bd_d3c9_41f4_9a91_f91a6b13130e
has only substance units: false
is: Q13057
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:80347
name: COASY
constant: false
boundary condition: true
is: SBO:0000252

metaR PRPNCOAHYDm
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110058#
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
reactant: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_8f05cf33_765b_4853_83b7_d55b16bc4289
initial amount: NaN
has only substance units: false
name: DHODH
is encoded by: hsa:1723
is: Q02127
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaM 20ahchsterol m
initial concentration: 1.0
boundary condition: false
is: CHEBI:1296
type: Species
is: SBO:0000247
name: 20-hydroxycholesterol
constant: false
initial amount: NaN
is: HMDB06283
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5d56a525_5b40_4631_a3d7_7cc960552c9f
initial concentration: NaN
initial amount: NaN
name: PANK2
type: Species
has only substance units: false
constant: false
is encoded by: hsa:80025
is: SBO:0000252
boundary condition: true

metaR r1653
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#

metaM arachdcoa m
type: Species
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57368
name: arachidonoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0

metaM itacon m
is: CHEBI:17240
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: itaconate(2-)
is: HMDB02092

http://identifiers.org/biomodels.db/MODEL1310110058#_f25ba608_6a30_49fd_8af5_b861e59bf101
initial amount: NaN
name: B3GNT1
boundary condition: true
is encoded by: hsa:11041
is: SBO:0000252
type: Species
constant: false
is: O43505
has only substance units: false
initial concentration: NaN

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_e5ace84b_9451_4cc9_85ae_b907090a3470
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:8869
name: ST3GAL5
is: Q9UNP4
type: Species
initial concentration: NaN
has only substance units: false

metaR AMACR2p
is: SBO:0000176
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
modifier: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: false
is version of: http://identifiers.org/ec-code/5.1.99.4
name: alpha-methylacyl-CoA racemase (reductase)
fast: false
type: Reaction
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110058#_1354e2f7_cbcb_4b2d_ab24_405fc3c7f590
is: SBO:0000252
type: Species
is encoded by: hsa:10423
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O14735
name: CDIPT

http://identifiers.org/biomodels.db/MODEL1310110058#_0635728a_1bd0_4a61_8a3e_c7e33012ecce
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: SLC26A1
boundary condition: true
is: Q9H2B4
initial amount: NaN
is encoded by: hsa:10861
is: SBO:0000252

metaR DOLPMT3 Ler
type: Reaction
reversible: false
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.260
modifier: MODEL1310110058#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110058#
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

metaM dhcholestancoa r
is: HMDB02159
is: SBO:0000247
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
type: Species
initial amount: NaN
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: CHEBI:15494
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR r0842
modifier: MODEL1310110058#
reversible: true
product: MODEL1310110058#
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
fast: false
reactant: MODEL1310110058#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_421fe545_3411_4cb3_bf15_83a134964b10
name: PPT1
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5538
is: SBO:0000252
boundary condition: true
is: Q6FGQ4
initial amount: NaN

metaR DURAD
product: MODEL1310110058#
name: dihydrouracil dehydrogenase (NADP)
kinetic law: MODEL1310110058#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reversible: true
modifier: MODEL1310110058#

metaR r1652
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PPCDC
type: Reaction
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110058#
kinetic law: MODEL1310110058#
name: phosphopantothenoylcysteine decarboxylase
reversible: false

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR DM btn
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for biotin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_702b74b0_20de_4680_9ba0_5c993553f37a
initial concentration: NaN
is: O60503
name: ADCY9
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:115
initial amount: NaN
is: SBO:0000252
type: Species

metaR r0570
product: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.3.2
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
reactant: MODEL1310110058#
type: Reaction
fast: false
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
modifier: MODEL1310110058#

metaM mlthf c
is: C00143
is: HMDB01533
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: SBO:0000247
constant: false
initial amount: NaN
name: 5,10-Methylenetetrahydrofolate
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:15636

metaR TAUPAT1c
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_60068dbb_3ef3_4ffa_bf76_797459856609
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:277
type: Species
is: P04745
initial concentration: NaN
name: AMY1B
initial amount: NaN

metaR r0276
kinetic law: MODEL1310110058#
is: SBO:0000176
product: MODEL1310110058#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110058#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
modifier: MODEL1310110058#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: true

metaR r1651
reactant: MODEL1310110058#
modifier: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_fb0316b1_dfd3_4d98_9cb7_3dc3ee943bfc
is encoded by: hsa:56901
boundary condition: true
initial concentration: NaN
constant: false
name: NDUFA4L2
is: Q9NRX3
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR TRIODTHYt2
type: Reaction
fast: false
name: T3 transport via facilitated diffusion
modifier: MODEL1310110058#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ

metaR r0840
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
modifier: MODEL1310110058#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110058#
name: Free diffusion
product: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.70
reactant: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_2f0141c2_7318_44e8_a79b_1956b2720f16
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: UGDH
type: Species
is encoded by: hsa:7358
is: O60701

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR r1650
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
fast: false
reactant: MODEL1310110058#
type: Reaction
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR 34HPPte
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is described by: ECO:0000134
type: Reaction
fast: false

metaR RE0453M
modifier: MODEL1310110058#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
kinetic law: MODEL1310110058#
fast: false
product: MODEL1310110058#

metaR GLNSERNaEx
type: Reaction
fast: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110058#
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)

http://identifiers.org/biomodels.db/MODEL1310110058#_250b2afa_4ce4_4d35_96dc_14f755d77710
type: Species
is: E9PDK1
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SLC4A9
boundary condition: true
is: SBO:0000252
is encoded by: hsa:83697

metaR r0841
modifier: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.271
name: Free diffusion
reversible: true
fast: false
kinetic law: MODEL1310110058#

metaM 4ppcys c
is: HMDB01117
is: C04352
is: SBO:0000247
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
constant: false
is: CHEBI:59458
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

metaM retinol cis 11 c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16302
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
is: SBO:0000247
name: 11-cis-retinol
type: Species
has only substance units: false
is: HMDB06216

http://identifiers.org/biomodels.db/MODEL1310110058#_8acc0a80_53d4_4893_ae88_646a62fd673b
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2348
has only substance units: false
name: FOLR1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_87a94a21_d235_4cb9_990c_93a1e6ea1c86
is: P82251
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:11136
name: SLC7A9
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_ee087a77_c73a_4857_a970_f29aa1e61df0
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: SDHD
constant: false
is: O14521
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6392

http://identifiers.org/biomodels.db/MODEL1310110058#_5e1245f0_677c_45c5_98aa_7ec34a088c1f
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:641372
name: ACOT6
is: Q3I5F7
has only substance units: false
initial amount: NaN

metaR r0426
fast: false
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.5.1.34
modifier: MODEL1310110058#
reactant: MODEL1310110058#
reversible: true
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
kinetic law: MODEL1310110058#
type: Reaction
is: SBO:0000176

metaR LPASE
reversible: false
fast: false
product: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.1.1.5
type: Reaction
modifier: MODEL1310110058#
name: lysophospholipase

metaR SMPD3g
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.12
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
modifier: MODEL1310110058#
is described by: ECO:0000304
reactant: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction

metaR G14T2g
reversible: false
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110058#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110058#

metaR r1657
reactant: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110058#

metaR CEPTC
reversible: false
fast: false
modifier: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: choline phosphotransferase
is described by: ECO:0000269
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.8.2

http://identifiers.org/biomodels.db/MODEL1310110058#_7c66e9bb_76b9_4ec3_b3fe_3b3847fe3a03
has part: P19404
has part: O43674
is encoded by: hsa:4731
is encoded by: hsa:4696
has part: P03915
has part: Q7GXY9
has part: Q6IB80
has part: O95299
is encoded by: hsa:4712
is encoded by: hsa:4722
has part: O75251
is encoded by: hsa:4707
is encoded by: hsa:4717
is encoded by: hsa:4535
is encoded by: hsa:4695
constant: false
has part: Q7GXZ4
has part: Q9Y6M9
has part: O95168
is encoded by: hsa:4708
has part: P56556
has part: Q16718
has part: P28331
has part: O75438
has part: Q6IBC4
is encoded by: hsa:55967
is encoded by: hsa:4725
is: SBO:0000297
has part: O00217
is encoded by: hsa:4698
has part: Q6FG42
is encoded by: hsa:4716
is encoded by: hsa:4726
has part: P56181
is encoded by: hsa:4539
has part: Q6IBB5
has part: O95139
is encoded by: hsa:4723
has part: A8K761
has part: O00483
has part: Q9P0J0
is encoded by: hsa:4538
is encoded by: hsa:51079
is encoded by: hsa:4709
is encoded by: hsa:4702
is encoded by: hsa:4719
is encoded by: hsa:4697
is encoded by: hsa:4541
is encoded by: hsa:4728
is encoded by: hsa:4718
is encoded by: hsa:4536
is encoded by: hsa:4700
has part: C9JT23
has part: H7C5B8
has part: Q6IBA0
is encoded by: hsa:4540
is encoded by: hsa:7991
has part: O95167
has part: Q85KV6
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: P17568
is encoded by: hsa:4713
boundary condition: true
is encoded by: hsa:4704
has part: P03905
is encoded by: hsa:4729
has part: Q549M5
has part: F8VQS7
is encoded by: hsa:4701
is encoded by: hsa:4711
has part: O43181
has part: O43677
has part: O14561
is encoded by: hsa:4694
is encoded by: hsa:374291
is encoded by: hsa:126328
is encoded by: hsa:4710
is encoded by: hsa:4720
has part: Q16795
has part: E5KNH5

http://identifiers.org/biomodels.db/MODEL1310110058#_fce7d68b_0644_4591_92fd_2bc79a99884e
name: BDH1
is encoded by: hsa:622
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_49ff6e66_ff63_4be3_aa8f_8cbba96ee837
name: SLC17A5
is: SBO:0000252
is: Q9NRA2
boundary condition: true
is encoded by: hsa:26503
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM Rtotal c
name: R total
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:16189
is: SBO:0000247
is: HMDB01448
notes: FORMULA: CO2FULLR CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110058#_149899ca_ad13_4361_bb9e_abeed07b9301
constant: false
is: SBO:0000252
boundary condition: true
is: Q9UHK6
is encoded by: hsa:23600
type: Species
initial amount: NaN
has only substance units: false
name: AMACR
initial concentration: NaN

metaR r2357
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
fast: false
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
type: Reaction

metaM CE4876 r
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57923
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: SBO:0000247
name: delta12-Prostaglandin J2
type: Species
boundary condition: false
initial concentration: 1.0

metaR r1299
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#

metaM ach e
is: HMDB00895
type: Species
name: acetylcholine
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
is: CHEBI:15355
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_68582f58_8362_438b_b07d_621cce69424e
name: NME1:NME2
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:4830
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110058#_dbccb4d3_4332_4d7f_9309_a1374d1deb6b
is: P56181
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: NDUFV3
is encoded by: hsa:4731
type: Species
has only substance units: false
constant: false

metaR 4HGLSDm
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
product: MODEL1310110058#
type: Reaction
reactant: MODEL1310110058#
is described by: ECO:0000212
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is: SBO:0000176

metaR r1656
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_baa9a534_4846_47ae_8ef0_07f2942824c7
initial concentration: NaN
is: SBO:0000252
type: Species
name: ACAT2
is: Q9BWD1
has only substance units: false
is encoded by: hsa:39
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_8a68f7ae_6b47_453e_8d10_eb85ce6ab9a2
constant: false
initial amount: NaN
is encoded by: hsa:3098
is: SBO:0000252
initial concentration: NaN
is: P19367
type: Species
has only substance units: false
name: HK1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_6c784be5_e294_4ac5_bf1a_75e66e2ad3b6
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: NT5C
is encoded by: hsa:30833
is: Q8TCD5

metaR r2358
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaM nh4 x
is: C01342
name: Ammonium
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00051
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
is: CHEBI:28938
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_490b6b93_09cc_4e0d_9094_14a50ae6db1f
name: B3GALNT1
is: SBO:0000252
is encoded by: hsa:8706
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: O75752
type: Species
initial amount: NaN

metaR r1298
type: Reaction
is described by: ECO:0000000
name: Vesicular transport
is: SBO:0000185
reversible: false
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_744c25aa_a913_4877_94ca_246c7d68b24d
name: SLC24A1
is encoded by: hsa:9187
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: B4DUG1
initial amount: NaN
has only substance units: false

metaR G14T12g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110058#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_5fd78c03_e053_4f23_9e00_e403edfdb65f
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: _8781_1_c
constant: false
is encoded by: hsa:8781
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_48d42236_faf2_4a79_bfcd_69b819c65446
name: NDUFS2
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:4720
constant: false
is: B7Z792
has only substance units: false
initial concentration: NaN

metaR ILEt5m
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: Isoleucine mitochondrial transport
is: SBO:0000185
fast: false
product: MODEL1310110058#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true

metaM mn l
constant: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
is: SBO:0000247
has only substance units: false
name: beta-1,4-mannose-N-acetylglucosamine
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: HMDB06535

metaM Rtotal e
notes: FORMULA: CO2FULLR CHARGE: -1
initial amount: NaN
name: R total
constant: false
boundary condition: false
is: CHEBI:3554
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00255
has only substance units: false
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110058#_cc12a4ca_ece7_447b_b17d_d08727fbc067
name: ATP2B4
initial concentration: NaN
type: Species
is encoded by: hsa:493
constant: false
has only substance units: false
is: P23634
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR C6DCCACT
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaR S6T9g
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110058#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110058#

metaR r2355
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110058#
is: SBO:0000185

metaR r1655
reactant: MODEL1310110058#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#

metaM 2hexdtetcoa m
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
constant: false
name: 2,7,10,13-hexadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110058#_ce13c810_15bf_4d9c_9571_cac66d5573c5
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: ADCY4
is encoded by: hsa:196883
is: Q8NFM4
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_cb98401f_fa9c_4975_8f36_31c1bf7d95e7
is encoded by: hsa:6579
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P46721
boundary condition: true
constant: false
name: SLCO1A2

metaR RE3004M
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110058#
fast: false
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3004
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#

metaM 1pipdn2c x
name: 1-piperideine-2-carboxylate
is: CHEBI:16187
is: HMDB01084
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r0425
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
product: MODEL1310110058#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
name: EC:1.1.1.42
reversible: true

metaM dmnoncrn m
name: 4,8 dimethylnonanoyl carnitine
type: Species
is: HMDB06202
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
boundary condition: false

metaR r1931
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110058#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport

metaM gln L m
type: Species
is: CHEBI:18050
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
initial amount: NaN
is: HMDB00641
name: L-glutamine
has only substance units: false

metaR r2356
fast: false
product: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_cdbda75b_805c_4530_8eef_c015fd650731
type: Species
name: _728226_1_m
constant: false
is encoded by: hsa:728226
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_4e4247c1_a81d_4e0d_81b2_590f04d2ff47
initial concentration: NaN
is: SBO:0000252
constant: false
name: _D29675_1_c
initial amount: NaN
is encoded by: hsa:D29675
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_ce8066b5_fb93_4f3f_a593_f81f845d74ad
has only substance units: false
name: SLC3A2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:6520
is: P08195

metaR r1654
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110058#
reversible: true
product: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110058#
is described by: ECO:0000000
fast: false

metaR r1934
modifier: MODEL1310110058#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110058#
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
is described by: ECO:0000000

metaM uri e
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00299
constant: false
boundary condition: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
is: CHEBI:16704
name: Uridine
is: SBO:0000247

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_f49126bf_4d28_49f9_adff_af81a251af19
is: SBO:0000252
boundary condition: true
name: GGT2
is encoded by: hsa:728441
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_a7124dcb_9697_4420_8f02_95813cb500d7
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:8875
is encoded by: hsa:55350
type: Species
has part: O95498
has only substance units: false
name: VNN3:VNN2:VNN1

metaR r2353
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110058#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110058#

metaM prostge1 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial concentration: 1.0
is: CHEBI:57397
initial amount: NaN
boundary condition: false
name: prostaglandin E1(1-)
is: SBO:0000247
is: HMDB01442
has only substance units: false
constant: false
type: Species

metaM c226crn c
name: cervonyl carnitine
is: http://identifiers.org/pubchem.compound/127055
has only substance units: false
initial amount: NaN
is: HMDB06510
boundary condition: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_101675ab_b0d3_4d6f_bfa6_c0bf0a64cbe2
constant: false
name: ENTPD8
has only substance units: false
type: Species
initial amount: NaN
is: Q5MY95
is: SBO:0000252
is encoded by: hsa:377841
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_1ab819ef_3aec_4a72_9667_daee2fc07272
name: CYP3A7
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P24462
has only substance units: false
is encoded by: hsa:1551
constant: false
type: Species
boundary condition: true

metaR r0578
reversible: true
is described by: ECO:0000000
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110058#
is: SBO:0000176

metaR 4HOXPACDOX NADP
product: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
kinetic law: MODEL1310110058#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110058#_fa84c83d_87a4_4250_b718_2082538a83c8
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6319
constant: false
initial concentration: NaN
is: O00767
initial amount: NaN
name: SCD

metaR RE0453C
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
type: Reaction
product: MODEL1310110058#
fast: false
reversible: true
name: RE0453
is: SBO:0000176

metaR FACOAL240
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110058#
fast: false
type: Reaction
reversible: true
is: SBO:0000176
name: fatty-acid--CoA ligase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110058#_fed92e5f_bdd4_4061_ac64_90dd82506e53
is encoded by: hsa:5211
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PFKL
is: Q7L2M7
type: Species
constant: false
is: SBO:0000252

metaM m6mpdol L r
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
has only substance units: false
is: CHEBI:37635
type: Species
constant: false
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20

metaM arachdcoa c
is: HMDB06523
is: CHEBI:57368
constant: false
initial concentration: 1.0
name: arachidonoyl-CoA(4-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
type: Species
initial amount: NaN

metaR r0423
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
fast: false
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_84c001ca_ccd7_4d7c_ad55_a6b7ca67d1fe
is: SBO:0000252
initial concentration: NaN
name: SLC7A2
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:6542
is: P52569
boundary condition: true

metaR GLYCTO1p
name: Glycolate oxidase, peroxisome
is version of: http://identifiers.org/ec-code/1.1.3.15
fast: false
reversible: false
modifier: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
type: Reaction
reactant: MODEL1310110058#

metaR r2354
name: Organic anion transporter 5 Utilized transport
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:32984
constant: false
boundary condition: false

metaM 4ppcys m
boundary condition: false
has only substance units: false
is: HMDB01117
initial concentration: 1.0
constant: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
is: CHEBI:59458

metaR MTHFD2m
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000254
kinetic law: MODEL1310110058#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is: SBO:0000176
product: MODEL1310110058#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
reactant: MODEL1310110058#

metaR r0579
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.13.11.19
is: SBO:0000176
modifier: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

metaR DESAT24 1
product: MODEL1310110058#
is described by: ECO:0000269
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
reversible: false
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
fast: false

metaM uri c
name: Uridine
constant: false
initial concentration: 1.0
is: C00299
initial amount: NaN
is: HMDB00296
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16704
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_a10b2b9b_5394_4976_b28e_708766ff555f
is: Q9H6Y6
name: MYO5B
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4645
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaR r1659
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR GULN3D
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
is described by: ECO:0000000
name: L-gulonate 3-dehydrogenase
is: SBO:0000176
reactant: MODEL1310110058#
product: MODEL1310110058#
reversible: true
type: Reaction
kinetic law: MODEL1310110058#

metaM CE0849 m
is: CHEBI:57795
is: SBO:0000247
has only substance units: false
boundary condition: false
name: cis,cis-palmito-7,10-dienoyl-CoA
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
initial concentration: 1.0

metaR FACOAL241
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110058#
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110058#
fast: false
is described by: ECO:0000000
name: fatty-acid--CoA ligase
modifier: MODEL1310110058#

metaM ach c
initial concentration: 1.0
constant: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
has only substance units: false
is: HMDB00895
type: Species
is: CHEBI:15355
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110058#_cd994cbd_a4bf_43e2_8aa5_987580d99948
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2643
name: GCH1
initial concentration: NaN
boundary condition: true
is: Q8IZH9
has only substance units: false

metaM man1p c
is: HMDB06330
initial amount: NaN
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:35374

http://identifiers.org/biomodels.db/MODEL1310110058#_40e3c0fa_a781_4ede_9e94_559210aadcc7
boundary condition: true
is encoded by: hsa:84129
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q709F0
name: ACAD11
is: SBO:0000252

metaM prostge1 e
initial amount: NaN
is: CHEBI:57397
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
boundary condition: false
is: HMDB01442
constant: false
name: prostaglandin E1(1-)
type: Species
has only substance units: false

metaR LTA4H
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
reversible: false
product: MODEL1310110058#
name: Leukotriene A-4 hydrolase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.3.2.6
reactant: MODEL1310110058#
is described by: ECO:0000134

metaR LSTO1r
is version of: http://identifiers.org/ec-code/1.14.21.6
name: Lathosterol oxidase
fast: false
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
type: Reaction
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
reactant: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_6ab57da7_76f3_4714_b9ec_12b0a396a7f4
initial concentration: NaN
name: MSMO1
constant: false
initial amount: NaN
is: A8MYF6
type: Species
has only substance units: false
is encoded by: hsa:6307
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_1a46a8a9_d63e_412d_a1c0_f7334efd4bae
type: Species
has part: E9PB82
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:3295
initial concentration: NaN
name: ACAA1:HSD17B4:ACOX1
is: SBO:0000297

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b2f96091_1c1e_4937_9851_eb33a6e42ed9
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9UJA2
is encoded by: hsa:54675
has only substance units: false
constant: false
boundary condition: true
name: CRLS1

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#
type: Reaction
fast: false
reactant: MODEL1310110058#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110058#
reversible: true

metaR RE0915E
name: RE0915
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
reversible: true
modifier: MODEL1310110058#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110058#_66a83664_3dfc_441d_95ed_b460b5c3217a
name: ITPKB
is: P27987
is encoded by: hsa:3707
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR RE2625M
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176
fast: false
name: RE2625
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110058#
type: Reaction
reversible: true
reactant: MODEL1310110058#
is described by: ECO:0000000

metaM pmtcrn r
boundary condition: false
has only substance units: false
is: HMDB00222
constant: false
initial amount: NaN
is: CHEBI:17490
initial concentration: 1.0
is: SBO:0000247
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species

metaR GLUDym
is version of: http://identifiers.org/ec-code/1.4.1.3
reversible: true
kinetic law: MODEL1310110058#
type: Reaction
product: MODEL1310110058#
is: SBO:0000176
modifier: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is described by: ECO:0000269
name: glutamate dehydrogenase (NADP), mitochondrial
reactant: MODEL1310110058#

metaR r2352
kinetic law: MODEL1310110058#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110058#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_e2bfab60_e746_4d53_b5d2_a7de51ab8fd9
initial amount: NaN
is encoded by: hsa:64077
constant: false
is: Q9H008
has only substance units: false
initial concentration: NaN
boundary condition: true
name: LHPP
is: SBO:0000252
type: Species

metaM 6a2ohxnt x
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: 6-amino-2-oxohexanoic acid
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
constant: false
is: HMDB12151
is: SBO:0000247
initial amount: NaN
is: CHEBI:17534

http://identifiers.org/biomodels.db/MODEL1310110058#_93217c38_8cdc_4e2d_9a63_c253a0e2775e
boundary condition: true
is: P14555
constant: false
type: Species
is encoded by: hsa:5320
initial concentration: NaN
name: PLA2G2A
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_6afac174_e891_4828_8a66_23d40d3d1e71
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1719
name: DHFR
initial concentration: NaN
type: Species
is: P00374

metaR R group phosphotase 1
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110058#
name: R group phosphotase 1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110058#
product: MODEL1310110058#
fast: false
type: Reaction
reversible: false

metaR r2126
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110058#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction

metaR PYNP2r
reactant: MODEL1310110058#
reversible: true
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.4.2.3
is described by: ECO:0000269
modifier: MODEL1310110058#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
fast: false
type: Reaction
name: pyrimidine-nucleoside phosphorylase (uracil)
product: MODEL1310110058#

metaR CYTK11n
fast: false
name: cytidylate kinase (dCMP,dGTP),nuclear
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110058#
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_28c3f042_9444_43c4_85a7_cd4296433564
is: P26572
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: MGAT1
is encoded by: hsa:4245
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR DCMPDA
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
modifier: MODEL1310110058#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.12
kinetic law: MODEL1310110058#
name: dCMP deaminase
reactant: MODEL1310110058#
is described by: ECO:0000254
product: MODEL1310110058#

metaM Rtotal2 e
is: SBO:0000247
name: R total 2 position
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00244
is: CHEBI:3554
is: C00255

metaR r0409
is: SBO:0000176
reversible: true
reactant: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
modifier: MODEL1310110058#
product: MODEL1310110058#
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is version of: http://identifiers.org/ec-code/3.2.1.10
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000

metaR RE3556C
is: SBO:0000176
kinetic law: MODEL1310110058#
is described by: ECO:0000000
reactant: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
product: MODEL1310110058#
name: RE3556
reversible: true

metaR r0002
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false
type: Reaction
name: Active transport
reactant: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
product: MODEL1310110058#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_35efde94_b2a1_43f5_b771_1ee5e38890a0
boundary condition: true
type: Species
has only substance units: false
name: AMPD3
is encoded by: hsa:272
is: B7Z763
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r2125
reversible: true
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110058#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#

metaR FAOXC225C226m
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaR ACONTm
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is described by: ECO:0000134
name: Aconitate hydratase
type: Reaction
reversible: true
reactant: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is: SBO:0000176

metaM glyb e
is: SBO:0000247
boundary condition: false
name: glycine betaine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17750
constant: false
is: HMDB00043
has only substance units: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaM carn c
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
initial amount: NaN
name: carnosine
is: CHEBI:15727
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00033

metaM dodecanac c
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: Dodecanedioic acid
is: SBO:0000247
has only substance units: false
notes: FORMULA: C12H20O4 CHARGE: -2
is: HMDB00623
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110058#_1840d795_59a6_4a03_a1d2_670c534ca1ff
constant: false
is encoded by: hsa:54995
is: Q9NWU1
initial amount: NaN
name: OXSM
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_f1a1b5ec_2e98_456b_9a66_6bc7ea370cab
is encoded by: hsa:506
initial amount: NaN
constant: false
type: Species
has part: P36542
is encoded by: hsa:513
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has part: P06576
is encoded by: hsa:514
is encoded by: hsa:509
has only substance units: false
initial concentration: NaN
is encoded by: hsa:498
is: SBO:0000297
boundary condition: true
has part: P56381
has part: A8K092
has part: P30049

metaM nadp r
is: HMDB00217
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
constant: false
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
is: C00006

metaR FACOAL184
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
name: fatty-acid--CoA ligase
is: SBO:0000176
modifier: MODEL1310110058#
reactant: MODEL1310110058#
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110058#
type: Reaction
reversible: true
fast: false

metaR IZPN
product: MODEL1310110058#
reversible: false
kinetic law: MODEL1310110058#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110058#
type: Reaction
name: Imidazolonepropionase

metaR r0408
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
type: Reaction
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
product: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110058#
reactant: MODEL1310110058#
fast: false

metaR r0139
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110058#
modifier: MODEL1310110058#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110058#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
reactant: MODEL1310110058#
is described by: ECO:0000000
is: SBO:0000176

metaR RE2625C
is described by: ECO:0000000
name: RE2625
is: SBO:0000176
reactant: MODEL1310110058#
fast: false
kinetic law: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110058#
type: Reaction

metaR TYMSULT
type: Reaction
kinetic law: MODEL1310110058#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000269
name: Tyramine Sulfotransferase
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
modifier: MODEL1310110058#

metaR ORETNtn2
is: SBO:0000185
kinetic law: MODEL1310110058#
type: Reaction
name: 13-cis-4-oxo-retinoic acid transport, Nuclear
reversible: true
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaM pail4p hs n
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:58178
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN

metaR r2128
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_0aa321df_2349_4e67_80c5_08d8df7b88dc
is: SBO:0000252
name: PLA2G2A
initial amount: NaN
is encoded by: hsa:5320
type: Species
has only substance units: false
initial concentration: NaN
is: P14555
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5223618d_4fbe_4f46_b79a_f3829860bac2
boundary condition: true
type: Species
name: PDE3B
initial concentration: NaN
has only substance units: false
is: Q13370
initial amount: NaN
is encoded by: hsa:5140
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_870b6017_de1f_460e_8dcb_b77db8695f0d
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:9380
is: Q9UBQ7
has only substance units: false
name: GRHPR
boundary condition: true
is: SBO:0000252
constant: false

metaR HCO3 NAt
modifier: MODEL1310110058#
is described by: ECO:0000006
reversible: true
reactant: MODEL1310110058#
fast: false
is: SBO:0000185
name: bicarbonate transport (Na/HCO3 cotransport)
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (9497.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10993873,PMID:14722772 NOTES:MM

metaM gthrd m
initial concentration: 1.0
name: glutathionate(1-)
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
is: CHEBI:57925
constant: false
has only substance units: false
boundary condition: false
is: HMDB00125
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_a6dda828_f04a_4383_8f72_c63b49c68093
boundary condition: true
is encoded by: hsa:27430
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9NZL9
has only substance units: false
name: MAT2B
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_8cea6371_072f_4648_b925_1b772ba8d060
constant: false
has only substance units: false
is encoded by: hsa:9415
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: O95864
type: Species
name: FADS2
initial concentration: NaN

metaR r2127
modifier: MODEL1310110058#
reversible: true
product: MODEL1310110058#
fast: false
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110058#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_fc592d7d_4634_4b09_a0bf_b6093a0b640f
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10317
name: B3GALT5
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaM leuktrE4 c
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: leukotriene E4(1-)
is: CHEBI:57462
is: HMDB02200
boundary condition: false
type: Species
has only substance units: false

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_89221d8b_9188_4d7b_a115_862e21c786a6
name: PDE9A
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5152

metaR GGT6
name: Gamma-glutamyltransferase
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110058#
product: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reversible: true
kinetic law: MODEL1310110058#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_5d06a60f_eca3_47d4_b43f_2e60201c17aa
boundary condition: true
is: B3KQ63
is: SBO:0000252
name: HPD
is encoded by: hsa:3242
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR BETALDHxm
is: SBO:0000176
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
name: betaine-aldehyde dehydrogenase, mitochondrial
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
product: MODEL1310110058#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR r2122
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110058#

metaR CHSTEROLt3
product: MODEL1310110058#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
name: cholesterol intracellular transport
reversible: true
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_641382af_a7a5_48e8_88d5_5d137d507b4e
name: _BE042354_1_m
is encoded by: hsa:BE042354
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaM c226crn m
constant: false
is: SBO:0000247
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06510
initial concentration: 1.0
name: cervonyl carnitine
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/127055
initial amount: NaN
type: Species

metaR SBCOAACOTx
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaM tetpent6coa c
initial amount: NaN
boundary condition: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
constant: false
is: SBO:0000247
name: tetracosapentaenoyl coenzyme A, n-6
type: Species
initial concentration: 1.0
is: C16172

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR r2347
type: Reaction
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110058#
is described by: ECO:0000000
product: MODEL1310110058#
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true

metaR r2121
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110058#
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false
modifier: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_04ec0671_a529_4a2f_acea_5d5db1fccd11
type: Species
is: SBO:0000252
name: MTHFD2
boundary condition: true
constant: false
has only substance units: false
is: P13995
initial concentration: NaN
is encoded by: hsa:10797
initial amount: NaN

metaM rbt c
name: D-ribitol
constant: false
is: CHEBI:15963
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508

metaR GLUTCOAACBP
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaR RE3524R
product: MODEL1310110058#
name: RE3524
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176

metaR CHSTEROLt2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
is: SBO:0000185
name: cholesterol intracellular transport
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
product: MODEL1310110058#
fast: false

metaR FAOXC6C4x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_534b8fdf_576b_4f6d_9e39_16dfb164a664
boundary condition: true
is: Q96Q11
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51095
constant: false
type: Species
name: TRNT1
initial concentration: NaN

metaR 3SALAASPm
is described by: ECO:0000304
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
reactant: MODEL1310110058#
is: SBO:0000185
reversible: true
product: MODEL1310110058#
type: Reaction
kinetic law: MODEL1310110058#
name: cysteinesulfinate-aspartate mitochondrial shuttle
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ba4197f0_f343_4f4e_a581_323935398953
has only substance units: false
type: Species
is encoded by: hsa:7378
boundary condition: true
is: Q16831
name: UPP1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR CEPTE
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.2
modifier: MODEL1310110058#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
product: MODEL1310110058#
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
type: Reaction
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: ethanolamine phosphotransferase

http://identifiers.org/biomodels.db/MODEL1310110058#_9d26b066_b030_4eb4_bb1b_0b8724daf633
name: SLC25A20
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:788
is: O43772
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110058#_813dd297_d693_4bc9_9200_a599e238def3
is encoded by: hsa:T83654
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _T83654_1_c
constant: false
type: Species
has only substance units: false
boundary condition: true

metaR r2124
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
kinetic law: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110058#_32883aa8_88f0_447c_9c2b_d801c52341de
initial concentration: NaN
is: B3KNC1
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:51733
has only substance units: false
boundary condition: true
is: SBO:0000252
name: UPB1

http://identifiers.org/biomodels.db/MODEL1310110058#_9702d154_c16c_4c8b_a972_6d077b2f0f6d
is: SBO:0000297
initial amount: NaN
name: ATP1A3:ATP1B2
has part: P14415
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:482

http://identifiers.org/biomodels.db/MODEL1310110058#_0bf24676_a332_4ced_a8ea_0977ea5683ea
boundary condition: true
type: Species
is: Q674R7
is encoded by: hsa:285973
has only substance units: false
initial concentration: NaN
name: ATG9B
is: SBO:0000252
initial amount: NaN
constant: false

metaM 4hoxpacd c
is: HMDB03767
is: CHEBI:15621
initial concentration: 1.0
name: (4-hydroxyphenyl)acetaldehyde
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
type: Species
has only substance units: false
constant: false

metaR CHSTEROLt1
reactant: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
product: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
name: cholesterol intracellular transport
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110058#
fast: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR r0407
reversible: true
fast: false
reactant: MODEL1310110058#
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
kinetic law: MODEL1310110058#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaM gthrd r
name: glutathionate(1-)
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57925

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR FAOXC12DCx
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaM Rtotal2 c
name: R total 2 position
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: SBO:0000247
is: CHEBI:57876
is: HMDB01564
has only substance units: false
initial amount: NaN

metaM glyb m
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
name: glycine betaine
constant: false
is: CHEBI:17750
boundary condition: false
is: HMDB00043
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_4fe7283a_83f4_44c0_b329_d509b8abc662
has only substance units: false
constant: false
boundary condition: true
type: Species
is: Q8N142
initial amount: NaN
is encoded by: hsa:122622
name: ADSSL1
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110058#_75cae0d5_6ec6_431d_8754_d9d30f1f5793
initial concentration: NaN
is: A8K8P8
is encoded by: hsa:2530
type: Species
boundary condition: true
name: FUT8
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaR r2123
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
modifier: MODEL1310110058#
reversible: true
product: MODEL1310110058#
reactant: MODEL1310110058#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110058#_ed2dc6c7_0e10_45e7_9c8d_1f04040a08e5
is: SBO:0000252
is encoded by: hsa:4538
initial amount: NaN
boundary condition: true
is: P03905
constant: false
type: Species
name: ND4
has only substance units: false
initial concentration: NaN

metaM hxan x
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
is: C00262
type: Species
is: CHEBI:17368
boundary condition: false
name: Hypoxanthine
is: HMDB00157
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR GLYBtm
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000185
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110058#_0b9e6a69_26f7_4799_a2a5_6a698f5aa591
name: _AI694761_1_c
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI694761
constant: false
is: SBO:0000252

metaR ACACT1rm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110058#
fast: false
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110058#
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110058#
type: Reaction
reversible: true
kinetic law: MODEL1310110058#
is described by: ECO:0000000

metaM 2dodtricoa m
is: SBO:0000247
is: C05280
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB03952
constant: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
name: 2,6,9-dodecatrienoylcoa
initial amount: NaN
type: Species

metaR ASNALANaEx
is: SBO:0000185
modifier: MODEL1310110058#
product: MODEL1310110058#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110058#
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110058#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_21557ee3_b5da_4d26_97a4_32acde406776
is encoded by: hsa:BF195998
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: _BF195998_1_x
initial amount: NaN

metaR C4x
kinetic law: MODEL1310110058#
product: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110058#_b9bba196_aaaa_46e6_af4e_7b2e4a008d63
name: COX6C
is: P09669
initial concentration: NaN
constant: false
is encoded by: hsa:1345
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110058#_4107c0b6_721d_4d53_94d6_080bc6f1e57c
is encoded by: hsa:2194
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: P49327
name: FASN
constant: false

metaM T antigen g
has only substance units: false
notes: FORMULA: C14H24NO10X CHARGE: 0
constant: false
is: SBO:0000247
name: T antigen (core 1)
type: Species
boundary condition: false
is: CHEBI:22783
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_99bd7c8c_99b8_4ba5_8f14_7bcf99a27aa8
is encoded by: hsa:51179
name: HAO2
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR RE1897C
reactant: MODEL1310110058#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
type: Reaction
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
name: RE1897
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110058#_0fc57724_648a_404e_b55f_b7964fc673ab
initial concentration: NaN
name: _AI373818_1_m
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI373818
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_819395ae_8921_452c_ba72_799a64c604cf
is encoded by: hsa:4017
is: SBO:0000252
boundary condition: true
type: Species
is: Q9Y4K0
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: LOXL2

metaR XOLDIOLONEt
name: lipid, flip-flop intracellular transport
product: MODEL1310110058#
fast: false
type: Reaction
reactant: MODEL1310110058#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110058#

metaM dece3coa m
name: 3-decenoylcoa
constant: false
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
is: SBO:0000247

metaM acetone m
type: Species
name: acetone
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
is: SBO:0000247
is: HMDB01659
is: CHEBI:15347
initial amount: NaN
constant: false
initial concentration: 1.0

metaM gua c
name: Guanine
is: HMDB00132
is: CHEBI:16235
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false
is: C00242
is: SBO:0000247
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242

http://identifiers.org/biomodels.db/MODEL1310110058#_529d5d8a_e438_47ab_b43a_999de12a4a4a
is: Q99643
boundary condition: true
is encoded by: hsa:6391
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SDHC
constant: false
initial amount: NaN
type: Species

metaR CHOLD2m
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.99.1
reversible: false
fast: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
is: SBO:0000176
product: MODEL1310110058#
name: choline dehydrogenase (FAD acceptor), mitochondrial
type: Reaction

metaM adp x
name: ADP(3-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
has only substance units: false
is: CHEBI:456216
constant: false
is: HMDB01341
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_4741f7f3_377b_43bb_bec4_8c9f9f323cba
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: P11586
is encoded by: hsa:4522
has only substance units: false
name: MTHFD1
type: Species

metaM Lfmkynr c
is: CHEBI:30249
is: HMDB01200
type: Species
name: N-formyl-L-kynurenine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H12N2O4 CHARGE: 0 INCHI: InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00985 EHMN_ABBREVIATION: C02700
initial amount: NaN
constant: false

metaR ASNGLNNaEx
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
is: SBO:0000185
modifier: MODEL1310110058#
product: MODEL1310110058#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110058#_cb6ae14b_9f95_479b_989a_fe9c4dce6b8f
name: LYZL1
type: Species
constant: false
is: SBO:0000252
is: Q6UWQ5
initial concentration: NaN
is encoded by: hsa:84569
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110058#_a74f97a9_c4c8_41ca_8554_eef32243101e
has only substance units: false
initial concentration: NaN
is encoded by: hsa:514
initial amount: NaN
boundary condition: true
name: ATP5E
is: SBO:0000252
constant: false
is: P56381
type: Species

http://identifiers.org/biomodels.db/MODEL1310110058#_13b176d5_dc5e_4628_bb18_7917450c0b35
initial amount: NaN
is encoded by: hsa:AA081045
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _AA081045_1_c

http://identifiers.org/biomodels.db/MODEL1310110058#_5a5b7813_edbb_4e3c_a691_bac53f431d56
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q9Y6K8
initial amount: NaN
boundary condition: true
name: AK5
type: Species
has only substance units: false
is encoded by: hsa:26289

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR r0860
is: SBO:0000185
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reversible: true
modifier: MODEL1310110058#
fast: false
name: Utilized transport
is described by: ECO:0000000
type: Reaction

metaR BTNDe
name: biotinidase (biotin), extracellular
modifier: MODEL1310110058#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110058#
reversible: false
type: Reaction
product: MODEL1310110058#
is: SBO:0000176
kinetic law: MODEL1310110058#

metaM tag hs c
constant: false
initial concentration: 1.0
initial amount: NaN
name: triglyceride
type: Species
boundary condition: false
is: CHEBI:17855
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0

metaR SPHK21c
product: MODEL1310110058#
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
reversible: false
is: SBO:0000176
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
name: sphingosine kinase 2
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.91
is described by: ECO:0000269
modifier: MODEL1310110058#
type: Reaction

metaR r2012
reactant: MODEL1310110058#
is described by: ECO:0000000
kinetic law: MODEL1310110058#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110058#
is: SBO:0000185
modifier: MODEL1310110058#

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM sbcoa c
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
type: Species
is: SBO:0000247
name: suberylcoa
constant: false
is: C02838
has only substance units: false
is: HMDB00791
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110058#_489329cc_ae45_4172_b74e_915cc8a620f4
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: AOC3
type: Species
is: Q16853
is encoded by: hsa:8639
initial amount: NaN
is: SBO:0000252

metaR ACNAM9PL
is described by: ECO:0000269
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
is version of: http://identifiers.org/ec-code/2.5.1.56
type: Reaction
reversible: false
modifier: MODEL1310110058#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
fast: false
product: MODEL1310110058#
kinetic law: MODEL1310110058#
is: SBO:0000176
reactant: MODEL1310110058#

metaR r0009
modifier: MODEL1310110058#
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is described by: ECO:0000000
product: MODEL1310110058#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
fast: false

metaR PI3P3Pn
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
reversible: false
product: MODEL1310110058#

http://identifiers.org/biomodels.db/MODEL1310110058#_3b4a2828_f989_462e_8a48_b856fe33d7f3
boundary condition: true
constant: false
name: LTC4S
is: Q16873
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4056

metaR r2120
modifier: MODEL1310110058#
product: MODEL1310110058#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110058#
reactant: MODEL1310110058#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM 3mop e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: SBO:0000247
has only substance units: false
is: HMDB00491
type: Species
constant: false
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
boundary condition: false

metaR q10h2tc
reactant: MODEL1310110058#
kinetic law: MODEL1310110058#
fast: false
is described by: ECO:0000134
name: transport of ubiquinol into cytosol
product: MODEL1310110058#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110058#_4bb9fdbd_21ae_4d0b_9aaa_1f1bcaec6078
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:5152
has only substance units: false
constant: false
name: PDE9A
initial concentration: NaN
initial amount: NaN

W3 CDTF: Fri Aug 31 04:30:23 BST 2012